Jessica Cardin, PhD
DownloadHi-Res Photo
Cards
Appointments
Neuroscience
Primary
Psychiatry
Secondary
Titles
Deputy Chair, Neuroscience
Contact Info
Appointments
Neuroscience
Primary
Psychiatry
Secondary
Titles
Deputy Chair, Neuroscience
Contact Info
Appointments
Neuroscience
Primary
Psychiatry
Secondary
Titles
Deputy Chair, Neuroscience
Contact Info
About
Titles
Professor of Neuroscience
Deputy Chair, NeuroscienceAppointments
Neuroscience
ProfessorPrimaryPsychiatry
Associate Professor on TermSecondary
Other Departments & Organizations
- Division of Neurocognition, Neurocomputation & Neurogenetics
- Interdepartmental Neuroscience Program
- Kavli Institute for Neuroscience
- Neuroscience
- Neuroscience Track
- Psychiatry
- Swartz Program in Theoretical Neurobiology
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
Education & Training
- PhD
- University of Pennsylvania (2004)
- BA
- Cornell University, Biology (1997)
Research
Overview
The cortex is made up of
interconnected networks containing many different classes of neurons, whose
roles in both normal brain activity and disease are poorly understood. Each neuron contributes to activity in
the surrounding local network and receives a constant barrage of network
synaptic input in return. The
Cardin lab investigates this dynamic and bidirectional relationship between
neuron and network at multiple levels, including cellular and synaptic mechanisms,
network interactions, and behavior.
We use a variety of techniques in rodent visual cortex, including
intracellular and extracellular recordings in vivo, chronic recordings in awake behaving animals, and
optogenetic manipulations of neural activity. A main goal of work in the laboratory is to identify and
understand synaptic interactions between excitatory and inhibitory neurons
during sensory processing. One ongoing focus is the cellular mechanisms
of visual gain control and how gain modulation regulates visual perception. A second focus is to understand the
flow of signals between cortical layers and how that process is affected by
recruitment of local inhibitory interneurons. We are also interested in how interactions between different
classes of neurons change in disease states such as epilepsy and schizophrenia.
One of the most fundamental elements of brain function is a reciprocal interaction between excitatory and inhibitory neurons. A major focus in the lab is to understand how these populations of neurons regulate each other and contribute to information processing. To explore this issue, we use intracellular and extracellular recordings, along with molecular genetics techniques. Using cell type-specific expression of optogenetic tools, such as light-activated channels (Channelrhodopsin and Halorhodopsin), we can control the firing of specific populations of excitatory and inhibitory neurons and test their impact on their synaptic targets. One project in the lab is focused on using these combined techniques to map out circuit dynamics in visual cortex in vivo.
A second project is using combined optogenetics and chronic tetrode recordings in awake behaving animals. We are recording patterns of visually evoked activity during awake visual behavior and testing the impact of changing inhibitory or excitatory activity on visual perception.
A third focus is to explore the cellular mechanisms of gain control in the brain. Gain is the amplification of inputs into outputs, and can be thought of as a 'volume control' for neurons. Gain modulation allows neurons to scale their output to any range of incoming inputs. This process is well documented across the brain, but very little is known about the underlying cellular mechanisms. We are exploring the role of synchrony between neurons as a mechanism for gain control in vivo.
In addition to exploring neural dynamics in the healthy brain, we are also interested in the mechanisms of neural dysregulation during disease. Using animal models, we are studying the roles that different populations of inhibitory interneurons may play in schizophrenia. We are also studying the initiation of epilepsy and how it may be controlled with new techniques for regulating neural activity.
A second project is using combined optogenetics and chronic tetrode recordings in awake behaving animals. We are recording patterns of visually evoked activity during awake visual behavior and testing the impact of changing inhibitory or excitatory activity on visual perception.
A third focus is to explore the cellular mechanisms of gain control in the brain. Gain is the amplification of inputs into outputs, and can be thought of as a 'volume control' for neurons. Gain modulation allows neurons to scale their output to any range of incoming inputs. This process is well documented across the brain, but very little is known about the underlying cellular mechanisms. We are exploring the role of synchrony between neurons as a mechanism for gain control in vivo.
In addition to exploring neural dynamics in the healthy brain, we are also interested in the mechanisms of neural dysregulation during disease. Using animal models, we are studying the roles that different populations of inhibitory interneurons may play in schizophrenia. We are also studying the initiation of epilepsy and how it may be controlled with new techniques for regulating neural activity.
Medical Subject Headings (MeSH)
Autistic Disorder; Cerebral Cortex; Electrophysiology; Epilepsy; Interneurons; Neurobiology; Neurosciences; Schizophrenia
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jessica Cardin's published research.
Publications Timeline
A big-picture view of Jessica Cardin's research output by year.
Research Interests
Research topics Jessica Cardin is interested in exploring.
Michael J Higley, MD/PhD
Quentin Perrenoud, PhD
Andrew Moberly
Chadi Abdallah, MD
Daniel Barson, PhD
Michael Crair, PhD
30Publications
4,675Citations
Interneurons
Cerebral Cortex
Electrophysiology
Neurosciences
Publications
2024
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Bottom-Tanzer S, Corella S, Meyer J, Sommer M, Bolaños L, Murphy T, Quiñones S, Heiney S, Shtrahman M, Whalen M, Oren R, Higley M, Cardin J, Noubary F, Armbruster M, Dulla C. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model. Cerebral Cortex 2024, 34: bhae038. PMID: 38365273, DOI: 10.1093/cercor/bhae038.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsControlled cortical impactTraumatic brain injuryFunctional connectivityDisrupted functional connectivityAssociated with improved cognitionReduced theta powerBrain injuryHuman TBI patientsModel of traumatic brain injuryBehavioral state-dependent changesNetwork connectivity changesFunctional cortical connectivityBrain regionsTheta powerConnectivity changesState-dependent changesCortical impactPeriods of locomotionCortical connectivityTBI patientsRodent modelsECoG activityMotor dysfunctionCortexInjured cortex
2023
The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo
Yu C, Yu Y, Adsit L, Chang J, Barchini J, Moberly A, Benisty H, Kim J, Young B, Heng K, Farinella D, Leikvoll A, Pavan R, Vistein R, Nanfito B, Hildebrand D, Otero-Coronel S, Vaziri A, Goldberg J, Ricci A, Fitzpatrick D, Cardin J, Higley M, Smith G, Kara P, Nielsen K, Smith I, Smith S. The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo. Nature Methods 2023, 21: 132-141. PMID: 38129618, PMCID: PMC10776402, DOI: 10.1038/s41592-023-02098-1.Peer-Reviewed Original ResearchCitationsAltmetricRapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonanceVIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexBeyond rhythm – a framework for understanding the frequency spectrum of neural activity
Perrenoud Q, Cardin J. Beyond rhythm – a framework for understanding the frequency spectrum of neural activity. Frontiers In Systems Neuroscience 2023, 17: 1217170. PMID: 37719024, PMCID: PMC10500127, DOI: 10.3389/fnsys.2023.1217170.Peer-Reviewed Original ResearchCitationsAltmetricNeural Integro-Differential Equations
Zappala E, O. Fonseca A, Moberly A, Higley M, Abdallah C, Cardin J, Van Dijk D. Neural Integro-Differential Equations. Proceedings Of The AAAI Conference On Artificial Intelligence 2023, 37: 11104-11112. DOI: 10.1609/aaai.v37i9.26315.Peer-Reviewed Original ResearchAltmetricConceptsIntegro-differential equationsIntegral operatorsDifferential equationsContinuous dynamical systemsNon-local dynamicsDynamical systemsInitial conditionsEquationsNeural networkTime extrapolationOperatorsIntegralsFundamental problemSuch dynamicsLatent spaceDynamicsNon-local processesBrain activity recordingsBrain dynamicsData scienceDifferential componentsIntegrandGeneralizationTheoryNetworkDevelopmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics
Batista-Brito R, Majumdar A, Nuño A, Ward C, Barnes C, Nikouei K, Vinck M, Cardin J. Developmental loss of ErbB4 in PV interneurons disrupts state-dependent cortical circuit dynamics. Molecular Psychiatry 2023, 28: 3133-3143. PMID: 37069344, PMCID: PMC10618960, DOI: 10.1038/s41380-023-02066-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPV interneuronsCortical neuronsCortical circuitsCortical circuit dynamicsCortical GABAergic cellsNRG1/ErbB4Excitatory cortical neuronsParvalbumin-Expressing InterneuronsInhibitory cortical neuronsApical dendritic tuftsActivity of excitatorySecond postnatal weekProper synaptic connectivityLate postnatal developmentState-dependent modulationLoss of ERBB4Excitatory componentGABAergic cellsGABAergic inhibitionSpine densityDendritic tuftsPostnatal weekNormal tuningSynaptic connectivityReceptor ErbB4Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity
Perrenoud Q, Cardin J. Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity. Neuron 2023, 111: 297-299. PMID: 36731427, DOI: 10.1016/j.neuron.2023.01.004.Peer-Reviewed Original ResearchAltmetric
2022
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani S, Moberly A, Benisty H, Landa B, Jing M, Li Y, Higley M, Cardin J. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nature Neuroscience 2022, 25: 1706-1713. PMID: 36443609, PMCID: PMC10661869, DOI: 10.1038/s41593-022-01202-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCortical network activityBehavioral statesCholinergic modulationAnimal's behavioral stateCholinergic signalingAwake miceCortical functionFunctional reorganizationNeuromodulatory influencesDifferent motor behaviorsNeocortical activityAcetylcholineMotor behaviorCortical networksRecent evidenceBrain activityFunctional segregationNeocortexMesoscopic imagingHeterogeneous signalsNetwork activityBehavioral markersBehavioral variablesCircuit dynamicsCholinergicDual-polarity voltage imaging of the concurrent dynamics of multiple neuron types
Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin J, Schnitzer M, Pieribone V. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types. Science 2022, 378: eabm8797. PMID: 36378956, PMCID: PMC9703638, DOI: 10.1126/science.abm8797.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements and Community Involvement
activity Chairperson
CommitteesCOSYNE MeetingDetails2010 - Presenthonor McKnight Scholar Award
National AwardMcKnight FoundationDetails01/01/2014United Statesactivity Chairperson
CommitteesCOSYNEDetails03/01/2011 - 03/01/2013DescriptionCosyne Workshopshonor Smith Family Award for Excellence in Biomedical Research
UnknownSmith Family FoundationDetails11/20/2012United Stateshonor Alfred P. Sloan Fellowship
UnknownAlfred P. Sloan FoundationDetails05/01/2012United States
Links & Media
News
- July 10, 2024
Highlighting Yale’s Neuroscience Research
- March 06, 2024Source: YouTube
How do we learn & how does our brain change between different mental states?
- September 10, 2021
Strittmatter Begins as Interim Chair of Department of Neuroscience
- November 03, 2019
Yale Scientists Capture Dynamic Brain in Action
Get In Touch
Contacts
Email
Academic Office Number