Selected Publications

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8. PMID: 30287806.

Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated with Opioid Dependence in European Americans. Biol Psychiatry. 2018 Nov 15;84(10):762-770. doi: 10.1016/j.biopsych.2017.12.016. Epub 2018 Jan 11. PMID: 29478698.

Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Mol Psychiatry. 2018 Jun 6. doi: 10.1038/s41380-018-0077-6. [Epub ahead of print] PMID: 29875475.

Polimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med. 2018 Mar 26;10(1):24. doi: 10.1186/s13073-018-0532-7. PMID: 29580271.

Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. Int J Neuropsychopharmacol. 2018 Jan 1;21(1):12-20. doi: 10.1093/ijnp/pyx087. PMID: 29106553.

Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated with Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275. PMID: 29071344.

Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clin Exp Res. 2017 Dec;41(12):2025-2032. doi: 10.1111/acer.13516. Epub 2017 Nov 13. PMID: 29131352.

Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex-specific linkage scans in opioid dependence Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):261-268. doi: 10.1002/ajmg.b.32507. Epub 2016 Oct 20. PMID: 27762075.

Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry. 2017 Mar;22(3):346-352. doi: 10.1038/mp.2016.257. Epub 2017 Jan 24. PMID: 28115739.

Polimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genet. 2017 Feb 10;13(2):e1006618. doi: 10.1371/journal.pgen.1006618. eCollection 2017 Feb. PMID: 28187187.

Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036. PMID: 27028160.

Main PubMed Publications

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. Nat Commun. 2019 Oct 8; 2019 Oct 8. PMID: 31594949.
Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.Sun Y, Chang S, Wang F, Sun H, Ni Z, Yue W, Zhou H, Gelernter J, Malison RT, Kalayasiri R, Wu P, Lu L, Shi J. Transl Psychiatry. 2019 Oct 7; 2019 Oct 7. PMID: 31591379.
Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.Xu K, Montalvo-Ortiz JL, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Alcohol Clin Exp Res. 2019 Oct; 2019 Aug 30. PMID: 31386212.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 Sep 3; 2019 Sep 3. PMID: 31481659.
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB. Biol Psychiatry. 2019 Sep 1; 2019 Apr 8. PMID: 31151762.
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Depress Anxiety. 2019 Sep; 2019 Aug 6. PMID: 31385647.
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Nat Neurosci. 2019 Sep; 2019 Jul 29. PMID: 31358989.
Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.Cheng Z, Yang BZ, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Addict Biol. 2019 Jul 30; 2019 Jul 30. PMID: 31362332.
Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study.Rentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC. AIDS Behav. 2019 Jul 17; 2019 Jul 17. PMID: 31317364.
Inviting in the Exome for Alcohol and Smoking Traits.Gelernter J. Biol Psychiatry. 2019 Jun 1. PMID: 31122339.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 May 17; 2019 May 17. PMID: 31101824.
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.Polimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. JAMA Netw Open. 2019 May 3; 2019 May 3. PMID: 31050786.
Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.Rosato AJ, Chen X, Tanaka Y, Farrer LA, Kranzler HR, Nunez YZ, Henderson DC, Gelernter J, Zhang H. Epigenomics. 2019 May; 2019 May 29. PMID: 31140863.
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium.Polimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg HJ, Kendler KS, Lewis CM, Sullivan PF, Wray NR, Gelernter J, Derks EM. Psychol Med. 2019 May; 2019 Apr 1. PMID: 30929657.
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 Apr 2; 2019 Apr 2. PMID: 30940813.
Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study.Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. World J Biol Psychiatry. 2019 Apr; 2017 Oct 5. PMID: 28891785.
Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Sci Rep. 2019 Mar 15; 2019 Mar 15. PMID: 30874594.
Alcohol-responsive genes identified in human iPSC-derived neural cultures.Jensen KP, Lieberman R, Kranzler HR, Gelernter J, Clinton K, Covault J. Transl Psychiatry. 2019 Mar 12; 2019 Mar 12. PMID: 30862775.
Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B.Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Int J Methods Psychiatr Res. 2019 Mar; 2019 Feb 14. PMID: 30767326.
Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants.Polimanti R, Nuñez YZ, Gelernter J. J Clin Med. 2019 Feb 22; 2019 Feb 22. PMID: 30813263.
Genetic associations with suicide attempt severity and genetic overlap with major depression.Levey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Transl Psychiatry. 2019 Jan 17; 2019 Jan 17. PMID: 30655502.
GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.Xiang B, Yang BZ, Zhou H, Kranzler H, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2019 Jan; 2018 Nov 28. PMID: 30488612.
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.Smith AH, Ovesen PL, Skeldal S, Yeo S, Jensen KP, Olsen D, Diazgranados N, Zhao H, Farrer LA, Goldman D, Glerup S, Kranzler HR, Nykjaer A, Gelernter J. Alcohol Clin Exp Res. 2018 Dec; 2018 Oct 25. PMID: 30252935.
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Mol Psychiatry. 2018 Dec; 2018 Jun 6. PMID: 29875475.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. Nat Neurosci. 2018 Dec; 2018 Nov 26. PMID: 30482948.
Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Biol Psychiatry. 2018 Nov 15; 2018 Jan 11. PMID: 29478698.
Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth.Kaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. J Pediatr. 2018 Nov; 2018 Aug 31. PMID: 30177354.
Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Transl Psychiatry. 2018 Oct 4; 2018 Oct 4. PMID: 30287806.
Methylation in OTX2 and related genes, maltreatment, and depression in children.Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Neuropsychopharmacology. 2018 Oct; 2018 Jul 21. PMID: 30089883.
Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers.Jensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Pharmacol Biochem Behav. 2018 Oct; 2018 Aug 11. PMID: 30107183.
Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.Ravera S, Carrasco N, Gelernter J, Polimanti R. J Clin Med. 2018 Sep 21; 2018 Sep 21. PMID: 30248900.
Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia.Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Schizophr Bull. 2018 Aug 20. PMID: 29534239.
Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2018 Jul. PMID: 30134085.
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Alcohol Clin Exp Res. 2018 May; 2018 Mar 13. PMID: 29460428.
Genetically determined schizophrenia is not associated with impaired glucose homeostasis.Polimanti R, Gelernter J, Stein DJ. Schizophr Res. 2018 May; 2017 Oct 29. PMID: 29092750.
Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.Polimanti R, Kayser MH, Gelernter J. Genome Med. 2018 Mar 26; 2018 Mar 26. PMID: 29580271.
ADH1B: From alcoholism, natural selection, and cancer to the human phenome.Polimanti R, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar; 2017 Mar 27. PMID: 28349588.
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Acta Psychiatr Scand. 2018 Feb; 2017 Dec 11. PMID: 29230810.
Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.Mota NP, Han S, Harpaz-Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Depress Anxiety. 2018 Feb; 2017 Nov 24. PMID: 29172227.
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis.Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Int J Neuropsychopharmacol. 2018 Jan 1. PMID: 29106553.
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. Mol Psychiatry. 2018 Jan; 2017 Mar 7. PMID: 28265120.
GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. Alcohol Clin Exp Res. 2017 Dec; 2017 Nov 13. PMID: 29131352.
Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Dec; 2017 Oct 9. PMID: 28990359.
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. JAMA Psychiatry. 2017 Dec 1. PMID: 29071344.
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J. Genome Med. 2017 Nov 27; 2017 Nov 27. PMID: 29178946.
Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. J Psychiatr Res. 2017 Nov; 2017 Jul 8. PMID: 28715704.
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI Jr, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. JAMA Psychiatry. 2017 Nov 1. PMID: 28813562.
Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. J Clin Psychiatry. 2017 Sep/Oct. PMID: 29099554.
Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder.Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Mol Psychiatry. 2017 Sep. PMID: 28831200.
Effects of ANK3 variation on gray and white matter in bipolar disorder.Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Mol Psychiatry. 2017 Sep; 2016 May 31. PMID: 27240527.
Review: DNA methylation and alcohol use disorders: Progress and challenges.Zhang H, Gelernter J. Am J Addict. 2017 Aug; 2016 Oct 19. PMID: 27759945.
Genetic risk variants for social anxiety.Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Jun; 2017 Apr 27. PMID: 28512750.
S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. J Psychiatry Neurosci. 2017 Jun. PMID: 28418321.
Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers.Polimanti R, Jensen KP, Gelernter J. Sci Rep. 2017 Apr 21; 2017 Apr 21. PMID: 28432340.
Sex-specific linkage scans in opioid dependence.Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr; 2016 Oct 20. PMID: 27762075.
Schizophrenia and substance use comorbidity: a genome-wide perspective.Polimanti R, Agrawal A, Gelernter J. Genome Med. 2017 Mar 21; 2017 Mar 21. PMID: 28327175.
Genome-wide association study of body mass index in subjects with alcohol dependence.Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Addict Biol. 2017 Mar; 2015 Oct 12. PMID: 26458734.
Genetic risk variants for social anxiety.Stein MB, Chen CY, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Mar. PMID: 28224735.
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Mol Psychiatry. 2017 Mar; 2017 Jan 24. PMID: 28115739.
Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury.Polimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. J Neurotrauma. 2017 Feb 15; 2016 Aug 25. PMID: 27439997.
Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder.Polimanti R, Gelernter J. PLoS Genet. 2017 Feb; 2017 Feb 10. PMID: 28187187.
Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes.Xu H, Wang F, Kranzler HR, Gelernter J, Zhang H. Sci Rep. 2017 Feb 6; 2017 Feb 6. PMID: 28165486.
A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. Mol Psychiatry. 2017 Feb; 2016 Apr 12. PMID: 27067016.
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2017 Feb; 2016 Aug 17. PMID: 27531626.
Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions.Wang Q, Polimanti R, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Hum Genet. 2017 Jan; 2016 Oct 17. PMID: 27752767.
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. Behav Brain Res. 2016 Dec 15; 2016 Aug 6. PMID: 27506655.
Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women.Polimanti R, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2016 Oct; 2016 May 17. PMID: 27187070.
Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Agrawal A, Edenberg HJ, Gelernter J. J Stud Alcohol Drugs. 2016 Sep. PMID: 27588522.
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. Nicotine Tob Res. 2016 Sep; 2016 Mar 31. PMID: 27611310.
Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits.Polimanti R, Yang BZ, Zhao H, Gelernter J. PLoS One. 2016; 2016 Aug 18. PMID: 27537407.
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers.Stein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. JAMA Psychiatry. 2016 Jul 1. PMID: 27167565.
FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study.Watkins LE, Han S, Harpaz-Rotem I, Mota NP, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Psychoneuroendocrinology. 2016 Jul; 2016 Apr 5. PMID: 27078785.
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. JAMA Psychiatry. 2016 May 1. PMID: 27028160.
Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.Clarke TK, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez-Pujals AM, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM. Addict Biol. 2016 Mar; 2015 Apr 10. PMID: 25865819.
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Schwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Behav Genet. 2016 Mar; 2015 Sep 21. PMID: 26392368.
DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders.Wang F, Xu H, Zhao H, Gelernter J, Zhang H. Sci Rep. 2016 Jan 14; 2016 Jan 14. PMID: 26763658.
RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders.Montalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. Am J Med Genet B Neuropsychiatr Genet. 2016 Jan; 2015 Nov 22. PMID: 26592203.
Further analyses support the association between light eye color and alcohol dependence.Sulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec; 2015 Aug 20. PMID: 26290254.
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS.Wang Q, Yang C, Gelernter J, Zhao H. Hum Genet. 2015 Nov; 2015 Sep 4. PMID: 26340901.
A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.Jensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. Neuropsychopharmacology. 2015 Nov; 2015 May 7. PMID: 25948103.
Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.Xiang Y, Kim KY, Gelernter J, Park IH, Zhang H. PLoS One. 2015; 2015 Aug 12. PMID: 26266540.
FKBP5 variation is associated with the acute and chronic effects of nicotine.Jensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. Pharmacogenomics J. 2015 Aug; 2014 Dec 23. PMID: 25532758.
Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.Xu K, Kranzler HR, Sherva R, Sartor CE, Almasy L, Koesterer R, Zhao H, Farrer LA, Gelernter J. Alcohol Clin Exp Res. 2015 Jul; 2015 Jun 3. PMID: 26036284.
Eye color: A potential indicator of alcohol dependence risk in European Americans.Sulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul; 2015 Apr 29. PMID: 25921801.
Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets.Vongpaisarnsin K, Listman JB, Malison RT, Gelernter J. Leg Med (Tokyo). 2015 Jul; 2015 Feb 25. PMID: 25759192.
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Biol Psychiatry. 2015 Mar 1; 2014 Sep 16. PMID: 25555482.
Genome-wide association study of copy number variations (CNVs) with opioid dependence.Li D, Zhao H, Kranzler HR, Li MD, Jensen KP, Zayats T, Farrer LA, Gelernter J. Neuropsychopharmacology. 2015 Mar; 2014 Sep 27. PMID: 25345593.
Genetics of complex traits in psychiatry.Gelernter J. Biol Psychiatry. 2015 Jan 1; 2014 Aug 13. PMID: 25444161.
Dissecting ancestry genomic background in substance dependence genome-wide association studies.Polimanti R, Yang C, Zhao H, Gelernter J. Pharmacogenomics. 2015; 2015 Aug 12. PMID: 26267224.
The joint effects of ADH1B variants and childhood adversity on alcohol related phenotypes in African-American and European-American women and men.Sartor CE, Wang Z, Xu K, Kranzler HR, Gelernter J. Alcohol Clin Exp Res. 2014 Dec; 2014 Nov 19. PMID: 25410943.
GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation.Chung D, Yang C, Li C, Gelernter J, Zhao H. PLoS Genet. 2014 Nov; 2014 Nov 13. PMID: 25393678.
Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways.Zhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Hum Genet. 2014 Nov; 2014 Jul 30. PMID: 25073604.
Genetic association of impulsivity in young adults: a multivariate study.Khadka S, Narayanan B, Meda SA, Gelernter J, Han S, Sawyer B, Aslanzadeh F, Stevens MC, Hawkins KA, Anticevic A, Potenza MN, Pearlson GD. Transl Psychiatry. 2014 Sep 30; 2014 Sep 30. PMID: 25268255.
Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Addict Biol. 2014 Sep; 2013 Jul 16. PMID: 23855403.
Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes.Zhang H, Wang F, Kranzler HR, Yang C, Xu H, Wang Z, Zhao H, Gelernter J. Hum Genet. 2014 Sep; 2014 Jun 3. PMID: 24889829.
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Biol Psychiatry. 2014 Jul 1; 2013 Oct 19. PMID: 24143882.
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Mol Psychiatry. 2014 Jun; 2013 Aug 20. PMID: 23958962.
Genetic risk prediction and neurobiological understanding of alcoholism.Levey DF, Le-Niculescu H, Frank J, Ayalew M, Jain N, Kirlin B, Learman R, Winiger E, Rodd Z, Shekhar A, Schork N, Kiefer F, Wodarz N, Müller-Myhsok B, Dahmen N, Nöthen M, Sherva R, Farrer L, Smith AH, Kranzler HR, Rietschel M, Gelernter J, Niculescu AB. Transl Psychiatry. 2014 May 20; 2014 May 20. PMID: 24844177.
Improving genetic risk prediction by leveraging pleiotropy.Li C, Yang C, Gelernter J, Zhao H. Hum Genet. 2014 May; 2013 Dec 13. PMID: 24337655.
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.Yang C, Li C, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Hum Genet. 2014 May; 2013 Dec 3. PMID: 24297757.