Selected Publications

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8. PMID: 30287806.

Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated with Opioid Dependence in European Americans. Biol Psychiatry. 2018 Nov 15;84(10):762-770. doi: 10.1016/j.biopsych.2017.12.016. Epub 2018 Jan 11. PMID: 29478698.

Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Mol Psychiatry. 2018 Jun 6. doi: 10.1038/s41380-018-0077-6. [Epub ahead of print] PMID: 29875475.

Polimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med. 2018 Mar 26;10(1):24. doi: 10.1186/s13073-018-0532-7. PMID: 29580271.

Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. Int J Neuropsychopharmacol. 2018 Jan 1;21(1):12-20. doi: 10.1093/ijnp/pyx087. PMID: 29106553.

Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated with Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275. PMID: 29071344.

Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clin Exp Res. 2017 Dec;41(12):2025-2032. doi: 10.1111/acer.13516. Epub 2017 Nov 13. PMID: 29131352.

Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex-specific linkage scans in opioid dependence Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):261-268. doi: 10.1002/ajmg.b.32507. Epub 2016 Oct 20. PMID: 27762075.

Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry. 2017 Mar;22(3):346-352. doi: 10.1038/mp.2016.257. Epub 2017 Jan 24. PMID: 28115739.

Polimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genet. 2017 Feb 10;13(2):e1006618. doi: 10.1371/journal.pgen.1006618. eCollection 2017 Feb. PMID: 28187187.

Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036. PMID: 27028160.

Main PubMed Publications

2021

The relationship between cannabis and schizophrenia: a genetically informed perspective.Johnson EC, Hatoum AS, Deak JD, Polimanti R, Murray RM, Edenberg HJ, Gelernter J, Di Forti M, Agrawal A. Addiction. 2021 Nov; 2021 May 19. PMID: 33950550.
The impact of removing former drinkers from genome-wide association studies of AUDIT-C.Dao C, Zhou H, Small A, Gordon KS, Li B, Kember RL, Ye Y, Gelernter J, Xu K, Kranzler HR, Zhao H, Justice AC. Addiction. 2021 Nov; 2021 May 6. PMID: 33861876.
Genetics of substance use disorders in the era of big data.Gelernter J, Polimanti R. Nat Rev Genet. 2021 Nov; 2021 Jul 1. PMID: 34211176.
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2021 Oct; 2021 Aug 26. PMID: 34446935.
Posttraumatic stress disorder: from gene discovery to disease biology.Polimanti R, Wendt FR. Psychol Med. 2021 Oct; 2021 Feb 15. PMID: 33583458.
Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition.Muniz Carvalho C, Wendt FR, Pathak GA, Maihofer AX, Stein DJ, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Neurobiol Stress. 2021 Nov; 2021 Sep 17. PMID: 34611531.
Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use.Wendt FR, Koller D, Pathak GA, Jacoby D, Miller EJ, Polimanti R. Clin Pharmacol Ther. 2021 Sep; 2021 Apr 30. PMID: 33837531.
ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility.Pathak GA, Wendt FR, Goswami A, Koller D, De Angelis F, Polimanti R. Front Genet. 2021; 2021 Aug 27. PMID: 34512723.
Potential causal effect of posttraumatic stress disorder on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study.Bountress KE, Wendt F, Bustamante D, Agrawal A, Webb B, Gillespie N, Edenberg H, Sheerin C, Johnson E, Polimanti R, Amstadter A. Alcohol Clin Exp Res. 2021 Aug; 2021 Jun 24. PMID: 34120358.
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization.Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. Nat Commun. 2021 Jul 27; 2021 Jul 27. PMID: 34315903.
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.De Lillo A, D'Antona S, Pathak GA, Wendt FR, De Angelis F, Fuciarelli M, Polimanti R. Hum Mol Genet. 2021 Jul 9. PMID: 33890984.
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Psychol Med. 2021 Jul 7; 2021 Jul 7. PMID: 34231451.
Role of microbes in the pathogenesis of neuropsychiatric disorders.Goswami A, Wendt FR, Pathak GA, Tylee DS, De Angelis F, De Lillo A, Polimanti R. Front Neuroendocrinol. 2021 Jul; 2021 May 4. PMID: 33957173.
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.Levey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Nat Neurosci. 2021 Jul; 2021 May 27. PMID: 34045744.
Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Hum Mol Genet. 2021 Jun 26. PMID: 33831179.
Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990-1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006.Radhakrishnan K, Hauser ER, Polimanti R, Helmer DA, Provenzale D, McNeil RB, Maffucci A, Quaden R, Zhao H, Whitbourne SB, Harrington KM, Vahey J, Gelernter J, Levey DF, Huang GD, Gaziano JM, Concato J, Aslan M. Brain Sci. 2021 Jun 25; 2021 Jun 25. PMID: 34202057.
Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.Mundy J, Hübel C, Gelernter J, Levey D, Murray RM, Skelton M, Stein MB, Vassos E, Breen G, Coleman JRI. Psychol Med. 2021 Jun 4; 2021 Jun 4. PMID: 34085609.
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Mullins N, Forstner AJ, O'Connell KS, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH, Abramova L, Adorjan K, Agerbo E, Al Eissa M, Albani D, Alliey-Rodriguez N, Anjorin A, Antilla V, Antoniou A, Awasthi S, Baek JH, Bækvad-Hansen M, Bass N, Bauer M, Beins EC, Bergen SE, Birner A, Bøcker Pedersen C, Bøen E, Boks MP, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cairns M, Casas M, Cervantes P, Clarke TK, Cruceanu C, Cuellar-Barboza A, Cunningham J, Curtis D, Czerski PM, Dale AM, Dalkner N, David FS, Degenhardt F, Djurovic S, Dobbyn AL, Douzenis A, Elvsåshagen T, Escott-Price V, Ferrier IN, Fiorentino A, Foroud TM, Forty L, Frank J, Frei O, Freimer NB, Frisén L, Gade K, Garnham J, Gelernter J, Giørtz Pedersen M, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha K, Haraldsson M, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hoffmann P, Holmans PA, Huckins L, Jamain S, Johnson JS, Kalman JL, Kamatani Y, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koromina M, Kranz TM, Kranzler HR, Kubo M, Kupka R, Kushner SA, Lavebratt C, Lawrence J, Leber M, Lee HJ, Lee PH, Levy SE, Lewis C, Liao C, Lucae S, Lundberg M, MacIntyre DJ, Magnusson SH, Maier W, Maihofer A, Malaspina D, Maratou E, Martinsson L, Mattheisen M, McCarroll SA, McGregor NW, McGuffin P, McKay JD, Medeiros H, Medland SE, Millischer V, Montgomery GW, Moran JL, Morris DW, Mühleisen TW, O'Brien N, O'Donovan C, Olde Loohuis LM, Oruc L, Papiol S, Pardiñas AF, Perry A, Pfennig A, Porichi E, Potash JB, Quested D, Raj T, Rapaport MH, DePaulo JR, Regeer EJ, Rice JP, Rivas F, Rivera M, Roth J, Roussos P, Ruderfer DM, Sánchez-Mora C, Schulte EC, Senner F, Sharp S, Shilling PD, Sigurdsson E, Sirignano L, Slaney C, Smeland OB, Smith DJ, Sobell JL, Søholm Hansen C, Soler Artigas M, Spijker AT, Stein DJ, Strauss JS, Świątkowska B, Terao C, Thorgeirsson TE, Toma C, Tooney P, Tsermpini EE, Vawter MP, Vedder H, Walters JTR, Witt SH, Xi S, Xu W, Yang JMK, Young AH, Young H, Zandi PP, Zhou H, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Babadjanova G, Backlund L, Baune BT, Bellivier F, Bengesser S, Berrettini WH, Blackwood DHR, Boehnke M, Børglum AD, Breen G, Carr VJ, Catts S, Corvin A, Craddock N, Dannlowski U, Dikeos D, Esko T, Etain B, Ferentinos P, Frye M, Fullerton JM, Gawlik M, Gershon ES, Goes FS, Green MJ, Grigoroiu-Serbanescu M, Hauser J, Henskens F, Hillert J, Hong KS, Hougaard DM, Hultman CM, Hveem K, Iwata N, Jablensky AV, Jones I, Jones LA, Kahn RS, Kelsoe JR, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Lochner C, Loughland C, Martin NG, Mathews CA, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Michie P, Milani L, Mitchell PB, Morken G, Mors O, Mortensen PB, Mowry B, Müller-Myhsok B, Myers RM, Neale BM, Nievergelt CM, Nordentoft M, Nöthen MM, O'Donovan MC, Oedegaard KJ, Olsson T, Owen MJ, Paciga SA, Pantelis C, Pato C, Pato MT, Patrinos GP, Perlis RH, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, Ribasés M, Rietschel M, Ripke S, Rouleau GA, Saito T, Schall U, Schalling M, Schofield PR, Schulze TG, Scott LJ, Scott RJ, Serretti A, Shannon Weickert C, Smoller JW, Stefansson H, Stefansson K, Stordal E, Streit F, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Waldman ID, Weickert TW, Werge T, Wray NR, Zwart JA, Biernacka JM, Nurnberger JI, Cichon S, Edenberg HJ, Stahl EA, McQuillin A, Di Florio A, Ophoff RA, Andreassen OA. Nat Genet. 2021 Jun; 2021 May 17. PMID: 34002096.
Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.Asch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. World J Biol Psychiatry. 2021 May 20; 2021 May 20. PMID: 33821766.
Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes.Campbell-Sills L, Sun X, Choi KW, He F, Ursano RJ, Kessler RC, Levey DF, Smoller JW, Gelernter J, Jain S, Stein MB. Psychol Med. 2021 May 5; 2021 May 5. PMID: 33947479.
Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study.Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Biol Psychiatry. 2021 May 1; 2020 Sep 30. PMID: 33276944.
Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support.Muniz Carvalho C, Wendt FR, Maihofer AX, Stein DJ, Stein MB, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Neuropsychopharmacology. 2021 May; 2020 Mar 16. PMID: 32179874.
Integration of evidence across human and model organism studies: A meeting report.Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. Genes Brain Behav. 2021 Apr 23; 2021 Apr 23. PMID: 33893716.
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome.Wendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Nat Hum Behav. 2021 Apr; 2020 Dec 21. PMID: 33349686.
GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals.Yang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. Addict Behav. 2021 Mar; 2020 Oct 10. PMID: 33153773.
Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality.Wendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Neurobiol Stress. 2021 May; 2021 Feb 18. PMID: 33665242.
Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms.Pathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Circ Genom Precis Med. 2021 Feb; 2021 Jan 11. PMID: 33428857.
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program.Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Nat Genet. 2021 Feb; 2021 Jan 28. PMID: 33510476.
Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality.Polimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Transl Psychiatry. 2021 Jan 11; 2021 Jan 11. PMID: 33431810.
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäebel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, Hopfer CJ, Iacono WG, Johnson EO, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson PKE, Nelson EC, Nöthen MM, Palmer AA, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose RJ, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Wade TD, Heath AC, Montgomery GW, Martin NG, Sullivan PF, Kaprio J, Breen G, Gelernter J, Edenberg HJ, Bulik CM, Agrawal A. Addict Biol. 2021 Jan; 2020 Feb 16. PMID: 32064741.
Characterizing the effect of background selection on the polygenicity of brain-related traits.Wendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Genomics. 2021 Jan; 2020 Dec 2. PMID: 33278486.

2020

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization.Pathak GA, Singh K, Miller-Fleming TW, Wendt FR, Ehsan N, Hou K, Johnson R, Lu Z, Gopalan S, Yengo L, Mohammadi P, Pasaniuc B, Polimanti R, Davis LK, Mancuso N. medRxiv. 2020 Dec 8; 2020 Dec 8. PMID: 33330876.
A large-scale genome-wide association study meta-analysis of cannabis use disorder.Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A. Lancet Psychiatry. 2020 Dec; 2020 Oct 20. PMID: 33096046.
Host genetic liability for severe COVID-19 overlaps with alcohol drinking behavior and diabetic outcomes in over 1 million participants.Wendt FR, De Lillo A, Pathak GA, De Angelis F, Polimanti R. medRxiv. 2020 Nov 18; 2020 Nov 18. PMID: 33200138.
ACE2 Netlas: In-silico functional characterization and drug-gene interactions of ACE2 gene network to understand its potential involvement in COVID-19 susceptibility.Pathak GA, Wendt FR, Goswami A, De Angelis F, Polimanti R. medRxiv. 2020 Oct 28; 2020 Oct 28. PMID: 33140059.
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.Xu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Nat Commun. 2020 Oct 20; 2020 Oct 20. PMID: 33082346.
Genetically-regulated transcriptomics & copy number variation of proctitis points to altered mitochondrial and DNA repair mechanisms in individuals of European ancestry.Pathak GA, Polimanti R, Silzer TK, Wendt FR, Chakraborty R, Phillips NR. BMC Cancer. 2020 Oct 2; 2020 Oct 2. PMID: 33008348.
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.Zhou H, Rentsch CT, Cheng Z, Kember RL, Nunez YZ, Sherva RM, Tate JP, Dao C, Xu K, Polimanti R, Farrer LA, Justice AC, Kranzler HR, Gelernter J. JAMA Psychiatry. 2020 Oct 1. PMID: 32492095.
Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort.Wendt FR, Carvalho CM, Pathak GA, Gelernter J, Polimanti R. PLoS Genet. 2020 Sep; 2020 Sep 17. PMID: 32941431.
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L, Edenberg HJ, Agrawal A, Gelernter J. Mol Psychiatry. 2020 Aug; 2020 Feb 26. PMID: 32099098.
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Nat Neurosci. 2020 Jul; 2020 May 25. PMID: 32451486.
Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective.Wendt FR, Pathak GA, Tylee DS, Goswami A, Polimanti R. Chronic Stress (Thousand Oaks). 2020 Jan-Dec; 2020 May 18. PMID: 32518889.
Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children.de Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Psychiatry Res Neuroimaging. 2020 Apr 30; 2020 Feb 22. PMID: 32120304.
Genome-wide scan identifies opioid overdose risk locus close to MCOLN1.Cheng Z, Yang BZ, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Addict Biol. 2020 Mar; 2019 Jul 30. PMID: 31362332.
Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF, Stein MB. Am J Psychiatry. 2020 Mar 1; 2020 Jan 7. PMID: 31906708.
Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study.Carvalho CM, Wendt FR, Stein DJ, Stein MB, Gelernter J, Belangero SI, Polimanti R. Mol Neurobiol. 2020 Mar; 2019 Nov 30. PMID: 31786776.

2019

Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Sci Rep. 2019 Dec 5; 2019 Dec 5. PMID: 31801960.
Genomewide Gene-by-Sex Interaction Scans Identify ADGRV1 for Sex Differences in Opioid Dependent African Americans.Yang BZ, Zhou H, Cheng Z, Kranzler HR, Gelernter J. Sci Rep. 2019 Dec 2; 2019 Dec 2. PMID: 31792237.
Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study.Rentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC. AIDS Behav. 2019 Dec. PMID: 31317364.
Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders.Wendt FR, Muniz Carvalho C, Pathak GA, Gelernter J, Polimanti R. J Clin Med. 2019 Nov 21; 2019 Nov 21. PMID: 31766499.
A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.Cheng Z, Phokaew C, Chou YL, Lai D, Meyers JL, Agrawal A, Farrer LA, Kranzler HR, Gelernter J. Transl Psychiatry. 2019 Nov 18; 2019 Nov 18. PMID: 31740666.
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. Nat Commun. 2019 Oct 8; 2019 Oct 8. PMID: 31594949.
Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison.Sun Y, Chang S, Wang F, Sun H, Ni Z, Yue W, Zhou H, Gelernter J, Malison RT, Kalayasiri R, Wu P, Lu L, Shi J. Transl Psychiatry. 2019 Oct 7; 2019 Oct 7. PMID: 31591379.
Epigenome-Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans.Xu K, Montalvo-Ortiz JL, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Alcohol Clin Exp Res. 2019 Oct; 2019 Aug 30. PMID: 31386212.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 Sep 3; 2019 Sep 3. PMID: 31481659.
Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB. Biol Psychiatry. 2019 Sep 1; 2019 Apr 8. PMID: 31151762.
Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study.Averill LA, Abdallah CG, Levey DF, Han S, Harpaz-Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Depress Anxiety. 2019 Sep; 2019 Aug 6. PMID: 31385647.
Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans.Gelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Nat Neurosci. 2019 Sep; 2019 Jul 29. PMID: 31358989.
Inviting in the Exome for Alcohol and Smoking Traits.Gelernter J. Biol Psychiatry. 2019 Jun 1. PMID: 31122339.
Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 May 17; 2019 May 17. PMID: 31101824.
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study.Polimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. JAMA Netw Open. 2019 May 3; 2019 May 3. PMID: 31050786.
Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.Rosato AJ, Chen X, Tanaka Y, Farrer LA, Kranzler HR, Nunez YZ, Henderson DC, Gelernter J, Zhang H. Epigenomics. 2019 May; 2019 May 29. PMID: 31140863.
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium.Polimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg HJ, Kendler KS, Lewis CM, Sullivan PF, Wray NR, Gelernter J, Derks EM. Psychol Med. 2019 May; 2019 Apr 1. PMID: 30929657.
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Kranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Nat Commun. 2019 Apr 2; 2019 Apr 2. PMID: 30940813.
Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study.Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. World J Biol Psychiatry. 2019 Apr; 2017 Oct 5. PMID: 28891785.
Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women.Montalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Sci Rep. 2019 Mar 15; 2019 Mar 15. PMID: 30874594.
Alcohol-responsive genes identified in human iPSC-derived neural cultures.Jensen KP, Lieberman R, Kranzler HR, Gelernter J, Clinton K, Covault J. Transl Psychiatry. 2019 Mar 12; 2019 Mar 12. PMID: 30862775.
Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B.Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Int J Methods Psychiatr Res. 2019 Mar; 2019 Feb 14. PMID: 30767326.
Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants.Polimanti R, Nuñez YZ, Gelernter J. J Clin Med. 2019 Feb 22; 2019 Feb 22. PMID: 30813263.
Genetic associations with suicide attempt severity and genetic overlap with major depression.Levey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Transl Psychiatry. 2019 Jan 17; 2019 Jan 17. PMID: 30655502.
GWAS and network analysis of co-occurring nicotine and alcohol dependence identifies significantly associated alleles and network.Xiang B, Yang BZ, Zhou H, Kranzler H, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2019 Jan; 2018 Nov 28. PMID: 30488612.

2018

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.Smith AH, Ovesen PL, Skeldal S, Yeo S, Jensen KP, Olsen D, Diazgranados N, Zhao H, Farrer LA, Goldman D, Glerup S, Kranzler HR, Nykjaer A, Gelernter J. Alcohol Clin Exp Res. 2018 Dec; 2018 Oct 25. PMID: 30252935.
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Mol Psychiatry. 2018 Dec; 2018 Jun 6. PMID: 29875475.
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. Nat Neurosci. 2018 Dec; 2018 Nov 26. PMID: 30482948.
Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Biol Psychiatry. 2018 Nov 15; 2018 Jan 11. PMID: 29478698.
Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth.Kaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. J Pediatr. 2018 Nov; 2018 Aug 31. PMID: 30177354.
Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Transl Psychiatry. 2018 Oct 4; 2018 Oct 4. PMID: 30287806.
Methylation in OTX2 and related genes, maltreatment, and depression in children.Kaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Neuropsychopharmacology. 2018 Oct; 2018 Jul 21. PMID: 30089883.
Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers.Jensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Pharmacol Biochem Behav. 2018 Oct; 2018 Aug 11. PMID: 30107183.
Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.Ravera S, Carrasco N, Gelernter J, Polimanti R. J Clin Med. 2018 Sep 21; 2018 Sep 21. PMID: 30248900.
Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia.Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Schizophr Bull. 2018 Aug 20. PMID: 29534239.
Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.Zhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2018 Jul. PMID: 30134085.
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population.Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Alcohol Clin Exp Res. 2018 May; 2018 Mar 13. PMID: 29460428.
Genetically determined schizophrenia is not associated with impaired glucose homeostasis.Polimanti R, Gelernter J, Stein DJ. Schizophr Res. 2018 May; 2017 Oct 29. PMID: 29092750.
Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits.Polimanti R, Kayser MH, Gelernter J. Genome Med. 2018 Mar 26; 2018 Mar 26. PMID: 29580271.
ADH1B: From alcoholism, natural selection, and cancer to the human phenome.Polimanti R, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar; 2017 Mar 27. PMID: 28349588.
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Acta Psychiatr Scand. 2018 Feb; 2017 Dec 11. PMID: 29230810.
Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.Mota NP, Han S, Harpaz-Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Depress Anxiety. 2018 Feb; 2017 Nov 24. PMID: 29172227.
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis.Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Int J Neuropsychopharmacol. 2018 Jan 1. PMID: 29106553.
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. Mol Psychiatry. 2018 Jan; 2017 Mar 7. PMID: 28265120.

2017

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. Alcohol Clin Exp Res. 2017 Dec; 2017 Nov 13. PMID: 29131352.
Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.Polimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Am J Med Genet B Neuropsychiatr Genet. 2017 Dec; 2017 Oct 9. PMID: 28990359.
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. JAMA Psychiatry. 2017 Dec 1. PMID: 29071344.
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.Polimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J. Genome Med. 2017 Nov 27; 2017 Nov 27. PMID: 29178946.
Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. J Psychiatr Res. 2017 Nov; 2017 Jul 8. PMID: 28715704.
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI Jr, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. JAMA Psychiatry. 2017 Nov 1. PMID: 28813562.
Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. J Clin Psychiatry. 2017 Sep/Oct. PMID: 29099554.
Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder.Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Mol Psychiatry. 2017 Sep. PMID: 28831200.
Effects of ANK3 variation on gray and white matter in bipolar disorder.Lippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Mol Psychiatry. 2017 Sep; 2016 May 31. PMID: 27240527.
Review: DNA methylation and alcohol use disorders: Progress and challenges.Zhang H, Gelernter J. Am J Addict. 2017 Aug; 2016 Oct 19. PMID: 27759945.