Selected Publications

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8. PMID: 30287806.

Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated with Opioid Dependence in European Americans. Biol Psychiatry. 2018 Nov 15;84(10):762-770. doi: 10.1016/j.biopsych.2017.12.016. Epub 2018 Jan 11. PMID: 29478698.

Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Mol Psychiatry. 2018 Jun 6. doi: 10.1038/s41380-018-0077-6. [Epub ahead of print] PMID: 29875475.

Polimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med. 2018 Mar 26;10(1):24. doi: 10.1186/s13073-018-0532-7. PMID: 29580271.

Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. Int J Neuropsychopharmacol. 2018 Jan 1;21(1):12-20. doi: 10.1093/ijnp/pyx087. PMID: 29106553.

Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated with Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275. PMID: 29071344.

Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clin Exp Res. 2017 Dec;41(12):2025-2032. doi: 10.1111/acer.13516. Epub 2017 Nov 13. PMID: 29131352.

Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex-specific linkage scans in opioid dependence Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):261-268. doi: 10.1002/ajmg.b.32507. Epub 2016 Oct 20. PMID: 27762075.

Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry. 2017 Mar;22(3):346-352. doi: 10.1038/mp.2016.257. Epub 2017 Jan 24. PMID: 28115739.

Polimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genet. 2017 Feb 10;13(2):e1006618. doi: 10.1371/journal.pgen.1006618. eCollection 2017 Feb. PMID: 28187187.

Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036. PMID: 27028160.

Main PubMed Publications

Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research.Cabrera-Mendoza B, Burmeister M, Rietschel M, Crepaz-Keay D, Balhara YPS, Seedat S, Marshe V, Hemmings S, Peterson R, Kaushik R, Viswanath B, Sud R, Haldar P, Johnstone M, Cherian AV, Lencz T, Zinkstok J, Polimanti R, Mueller DJ, Lázaro-Muñoz G, Liu C, John N 1st, Nicolini H, Walss-Bass C, Santoro M, Satapathy S, Behera C, Docherty AR. Am J Med Genet B Neuropsychiatr Genet. 2025 Jul 10; 2025 Jul 10. PMID: 40635475.
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses.Shen J, Valentim W, Friligkou E, Overstreet C, Choi KW, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. Nat Commun. 2025 Jul 1; 2025 Jul 1. PMID: 40595462.
Integration of Metabolomic and Brain Imaging Data Highlights Pleiotropy Among Posttraumatic Stress Disorder, Glycoprotein Acetyls, and Pallidum Structure.Løkhammer S, Tesfaye M, Cabrera-Mendoza B, Sandås K, Pathak GA, Friligkou E, Le Hellard S, Polimanti R. Biol Psychiatry Glob Open Sci. 2025 Jul; 2025 Mar 17. PMID: 40270839.
Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries.Wang L, Kranzler HR, Gelernter J, Zhou H. Biol Psychiatry. 2025 Jul 1; 2025 Jan 30. PMID: 39892688.
Integrated Gene and Isoform-Level Transcriptomic Analysis of Adverse Childhood Experiences in the Human Prefrontal Cortex.Núñez-Ríos DL, Nagamatsu ST, Martínez-Magaña JJ, Montalvo-Ortiz JL. Yale J Biol Med. 2025 Jun; 2025 Jun 30. PMID: 40589944.
The Psychiatric Genomics Consortium: discoveries and directions.Agrawal A, Bulik CM, Abebe DS, Andreassen OA, Atkinson EG, Choi KW, Corvin A, Davies HL, Davis LK, Docherty AR, Edenberg HJ, Franke B, Gelernter J, Giusti-Rodríguez P, Hettema JM, Hjerling-Leffler J, Huang H, Johnson EC, Lewis CM, Lu Y, Lynall ME, Martin J, McIntosh AM, Montalvo-Ortiz JL, Mullins N, Nievergelt CM, O'Connell KS, O'Donovan MC, Okewole A, Peterson RE, Posthuma D, Sebat J, Smoller JW, Sud R, Viswanath B, Walters JTR, Won H, Wray NR, Sullivan PF. Lancet Psychiatry. 2025 Jun 26; 2025 Jun 26. PMID: 40582370.
The landscape of suicide risk factors in Latin America.Cabrera-Mendoza B, Fries GR, Polimanti R. Psychiatry Res. 2025 Jun 16; 2025 Jun 16. PMID: 40674133.
Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults.Didriksen M, Daníelsdottir H, Bjarnadóttir MD, Overstreet C, Choi KW, Christoffersen LAN, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir EB, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun MT, Ullum H, Sørensen E, Fischer IC, Pietrzak RH, Gelernter J, Campbell-Sills L, Stein MB, Werge T, Pedersen OB, Valdimarsdóttir U, Ostrowski SR, Schork AJ. J Mood Anxiety Disord. 2025 Jun; 2025 Feb 17. PMID: 40657597.
Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.Kranzler HR, Jinwala Z, Davis CN, Xu H, Biernacka JM, Zhou H, Kember RL, Gelernter J, Feinn R. Alcohol Clin Exp Res (Hoboken). 2025 Jun; 2025 May 30. PMID: 40445294.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckman J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Artigas MS, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Hellard SL, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. Nat Genet. 2025 Jun; 2025 May 13. PMID: 40360802.
Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans.Fischer IC, Overstreet C, Cabrera-Mendoza B, Qiu D, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. World J Biol Psychiatry. 2025 Jun; 2025 May 9. PMID: 40343713.
Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability.Friligkou E, Koller D, Pathak GA, Miller EJ, Lampert R, Stein MB, Polimanti R. Mol Psychiatry. 2025 Jun; 2024 Nov 18. PMID: 39558002.
A contextual genomic perspective on physical activity and its relationship to health, well-being and illness.Galimberti M, Levey DF, Deak JD, Adhikari K, Overstreet C, Gupta P, Nitin R, Zhou H, Lake NJ, Harrington KM, Djousse L, Davis LK, Gaziano JM, Stein MB, Gelernter J. medRxiv. 2025 May 28; 2025 May 28. PMID: 40321252.
Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes.Austin-Zimmerman I, Levey DF, Deak JD, Galimberti M, Adhikari K, Coleman JRI, Buysse DJ, Wilson PWF, Sofer T, Gaziano JM, Gottlieb DJ, Stein MB, Forti MD, Gelernter J. medRxiv. 2025 May 21; 2025 May 21. PMID: 40475156.
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality.Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, Dragostinov Y, Liao W, Ackerman LS, Fealy JCM, Hemani G, de la Fuente J, Gupta P, Stein MB, Gelernter J, Levey DF, Võsa U, Ausmees L, Realo A, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir GA, Thorleifsson G, Gunnarsson ÁF, Bjornsdottir G, Thorgeirsson TE, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield EC, Ask H, Torvik FA, Ystrom E, Tesli M, Boomsma DI, de Geus EJC, Hottenga JJ, Melo DC, Snieder H, Hartman CA, Xia C, Campbell A, Luciano M, Deary IJ, Hill WD, Jang SK, Vrieze SI, Abecasis G, Lupton MK, Mitchell BL, Viher PV, Colodro-Conde L, Martin NG, Medland SE, Derks EM, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Gidziela A, Rimfeld K, Plomin R, Malanchini M, Dick DM, Aliev F, Wesseldijk LW, Ullén F, Mosing MA, Kranzler HR, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby EA, Lee JJ, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin AR, van der Most PJ, Oldehinkel AJ, Kretschmer T, Shabalin AA, Docherty AR, Krueger RF, Freilich CD, Mishra BH, Lehtimäki T, Raitakari OT, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt SH, Tuhkanen J, Räikkönen K, Eriksson JG, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ TC, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden KP, Genç E, Gajewski PD, Getzmann S, Fraenz C, Schneider Peñate JE, Lis S, Hall ASM, Schmahl C, Herpertz SC, Abdellaoui A, Nivard MG, Tucker-Drob EM. bioRxiv. 2025 May 19; 2025 May 19. PMID: 40475535.
Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program.Pathak GA, Koller D, Cabrera-Mendoza B, Nono Djotsa ABS, Wendt FR, De Lillo A, Friligkou E, He J, Kouakou MR, Duong LM, Vahey J, Steele L, Quaden R, Harrington KM, Ahmed ST, Gaziano JM, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer DA, Hauser ER, Polimanti R. Hum Mol Genet. 2025 May 14; 2025 May 14. PMID: 40366759.
PTSD and epigenetic aging: a longitudinal meta-analysis.Zhao X, Katrinli S, McCormick BM, Miller MW, Nugent NR, Wani AH, Zannas AS, Aiello AE, Baker DG, Boks MP, Chen CY, Fortier CB, Gelernter J, Geuze E, Koenen KC, Linnstaedt SD, Luykx JJ, Maihofer AX, McLean SA, Milberg WP, Ratanatharathorn A, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Zhao Y, Logue MW, Nievergelt CM, Smith AK, Uddin M, Wolf EJ. Psychol Med. 2025 May 14; 2025 May 14. PMID: 40366073.
Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis.Friligkou E, Pathak GA, Tylee DS, De Lillo A, Koller D, Cabrera-Mendoza B, Polimanti R. Psychol Med. 2025 May 13; 2025 May 13. PMID: 40357923.
Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 9; 2025 May 9. PMID: 40340892.
Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. Psychol Med. 2025 May 8; 2025 May 8. PMID: 40336358.
Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias.He J, Cabrera-Mendoza B, Friligkou E, Mecca AP, van Dyck CH, Pathak GA, Polimanti R. Alzheimers Dement. 2025 May. PMID: 40421744.
Psychiatric genetics in the diverse landscape of Latin American populations.Bruxel EM, Rovaris DL, Belangero SI, Chavarría-Soley G, Cuellar-Barboza AB, Martínez-Magaña JJ, Nagamatsu ST, Nievergelt CM, Núñez-Ríos DL, Ota VK, Peterson RE, Sloofman LG, Adams AM, Albino E, Alvarado AT, Andrade-Brito D, Arguello-Pascualli PY, Bandeira CE, Bau CHD, Bulik CM, Buxbaum JD, Cappi C, Corral-Frias NS, Corrales A, Corsi-Zuelli F, Crowley JJ, Cupertino RB, da Silva BS, De Almeida SS, De la Hoz JF, Forero DA, Fries GR, Gelernter J, González-Giraldo Y, Grevet EH, Grice DE, Hernández-Garayua A, Hettema JM, Ibáñez A, Ionita-Laza I, Lattig MC, Lima YC, Lin YS, López-León S, Loureiro CM, Martínez-Cerdeño V, Martínez-Levy GA, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares AM, Oliveira VF, Ormond R, Palmer AA, Panzenhagen AC, Passos-Bueno MR, Peng Q, Pérez-Palma E, Prieto ML, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis FM, Sharp RR, Storch EA, Tavares MEA, Tietz GE, Torres-Hernández BA, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan EM, Velásquez MM, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Santoro ML, Nicolini H, Atkinson EG, Giusti-Rodríguez P, Montalvo-Ortiz JL. Nat Genet. 2025 May; 2025 Apr 2. PMID: 40175716.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. Nat Hum Behav. 2025 May; 2025 Mar 31. PMID: 40164914.
Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD.Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Brain Behav Immun. 2025 Apr 24; 2025 Apr 24. PMID: 40286993.
Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez YZ, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. Mol Psychiatry. 2025 Apr 17; 2025 Apr 17. PMID: 40247127.
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.Cakir B, Tanaka Y, Choe MS, Chu PY, Xiang Y, Kim KY, Zhong M, Gelernter J, Zhang H, Krystal J, Park IH. Int J Stem Cells. 2025 Apr 10; 2025 Apr 10. PMID: 40205763.
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Bäckmann J, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, Skogholt AH, Sloofman LG, Smit J, Soler Artigas M, Thomas LF, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink NN, Walker CP, Wang Y, Wendland JR, Winsvold BS, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz KK, Bulik CM, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez TV, Fyer AJ, Gaziano JM, Geller DA, Grabe HJ, Greenberg BD, Hanna GL, Hickie IB, Hougaard DM, Kathmann N, Kennedy J, Lai D, Landén M, Le Hellard S, Leboyer M, Lochner C, McCracken JT, Medland SE, Mortensen PB, Neale BM, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls DL, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga JA, Rasmussen SA, Richter MA, Rosenberg DR, Ruhrmann S, Samuels JF, Sandin S, Sandor P, Spalletta G, Stein DJ, Stewart SE, Storch EA, Stranger BE, Turiel M, Werge T, Andreassen OA, Børglum AD, Walitza S, Hveem K, Hansen BK, Rück C, Martin NG, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart JA, Breen G, Nestadt G, Kaprio J, Arnold PD, Grice DE, Knowles JA, Ask H, Verweij KJ, Davis LK, Smit DJ, Crowley JJ, Scharf JM, Stein MB, Gelernter J, Mathews CA, Derks EM, Mattheisen M. medRxiv. 2025 Apr 8; 2025 Apr 8. PMID: 38712091.
Observational and Genetic Analyses of Traumatic Experiences and Endometriosis.Koller D, Løkhammer S, Goroshchuk O, Denner V, Stiltner B, Mitjans M, He J, Taylor HS, Lawn RB, Koenen KC, Polimanti R. JAMA Psychiatry. 2025 Apr 1. PMID: 39908042.
Understanding the comorbidities among psychiatric disorders, chronic low-back pain, and spinal degenerative disease using observational and genetically informed analyses.Qiu D, Friligkou E, He J, Cabrera-Mendoza B, Aslan M, Gupta M, Polimanti R. medRxiv. 2025 Mar 4; 2025 Mar 4. PMID: 40093242.
A multicenter cross-sectional study of gambling disorder among patients with methamphetamine use disorder in drug rehabilitation centers: prevalence, correlates, and network analysis.Peng P, Hao Y, Zhang X, Ma Y, Liu X, Shen D, Shen W, Zhao B, Li D, Beck SE, Nunez YZ, Potenza MN, Gelernter J, Liu T, Yang BZ. Ann Gen Psychiatry. 2025 Mar 3; 2025 Mar 3. PMID: 40033412.
Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors.Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Transl Psychiatry. 2025 Feb 20; 2025 Feb 20. PMID: 39979292.
Integrating HiTOP and RDoC Frameworks Part I: Genetic Architecture of Externalizing and Internalizing Psychopathology.Davis CN, Khan Y, Toikumo S, Jinwala Z, Boomsma DI, Levey DF, Gelernter J, Kember RL, Kranzler HR. medRxiv. 2025 Feb 5; 2025 Feb 5. PMID: 38645045.
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.Johnson EC, Lai D, Miller AP, Hatoum AS, Deak JD, Balbona JV, Baranger DA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SM, Sanchez-Roige S, Adhikari K, Docherty A, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries P, Korhonen T, Morrison C, Nunez YZ, Palviainen T, Su MH, Villela PNR, Wetherill L, Willoughby EA, Zellers S, Bierut L, Buchwald J, Copeland W, Corley R, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio JA, Keller MC, Lee JL, Lind PA, Madden PA, Maes HH, Martin NG, McGue M, Medland SE, Nelson EC, Pearson JV, Porjesz B, Stallings M, Vrieze S, Wilhelmsen KC, Walters RK, Polimanti R, Malison RT, Zhou H, Stefansson K, Potenza MN, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A. medRxiv. 2025 Feb 3; 2025 Feb 3. PMID: 39974067.
Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder.Icick R, Shadrin A, Holen B, Karadag N, Parker N, O'Connell KS, Frei O, Bahrami S, Høegh MC, Lagerberg TV, Cheng W, Seibert TM, Djurovic S, Dale AM, Zhou H, Edenberg HJ, Gelernter J, Smeland OB, Hindley G, Andreassen OA. Nat Ment Health. 2025 Feb; 2025 Jan 8. PMID: 40322774.
Genes in context: path to more precise risk prediction in psychiatry?Na PJ, Pietrzak RH, Gelernter J. Br J Psychiatry. 2025 Feb; 2024 Oct 18. PMID: 39422146.
A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases.Lukas E, Veeneman RR, Smit DJA, Ahluwalia TS, Vermeulen JM, Pathak GA, Polimanti R, Verweij KJH, Treur JL. Transl Psychiatry. 2025 Jan 4; 2025 Jan 4. PMID: 39755697.
A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies.Huang YJ, Kurniansyah N, Levey DF, Gelernter J, Huffman JE, Cho K, Wilson PWF, Gottlieb DJ, Rice KM, Sofer T. medRxiv. 2025 Jan 2; 2025 Jan 2. PMID: 39802770.
Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2025 Jan. PMID: 39643700.
Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health.Kouakou MR, Cabrera-Mendoza B, Pathak GA, Cannon TD, Polimanti R. Schizophr Bull. 2024 Dec 20. PMID: 38848523.
Opioid use disorder and brain health: observational and genetic associations.Javidnia S, Roe JM, Karhunen V, Gill D, Bell S, Deak J, Levey D, Cronje T, Burgess S, Gelernter J, Ebmeier KP, Topiwala A. medRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 39763526.
Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Malone SG, Davis CN, Piserchia Z, Setzer MR, Toikumo S, Zhou H, Winterlind EL, Gelernter J, Justice A, Leggio L, Rentsch CT, Kranzler HR, Gray JC. medRxiv. 2024 Dec 14; 2024 Dec 14. PMID: 38746260.
Posttraumatic Stress Disorder, Obesity, and Accelerated Epigenetic Aging Among US Military Veterans.Fischer IC, Na PJ, Nagamatsu ST, Jeste DV, Cabrera-Mendoza B, Montalvo-Ortiz JL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. JAMA Psychiatry. 2024 Dec 1. PMID: 39476130.
Identifying Genetically Inferred Effects Linking Posttraumatic Stress Disorder to Women's Health, Lipid Disorders, and Malaria Medications.Pathak GA, Wendt FR, Maihofer AX, Ressler KJ, Stein MB, Koenen KC, Nievergelt CM, Polimanti R. Am J Psychiatry. 2024 Dec 1; 2024 Oct 9. PMID: 39380377.
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction.Braun A, Shekhar S, Levey DF, Straub P, Kraft J, Panagiotaropoulou GM, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas AG, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir AT, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein MB, Fontanillas P, Kaprio J, Gelernter J, Davis LK, Paschou P, Tannemaat MR, Verschuuren JJGM, Kuhlenbäumer G, Gregersen PK, Huijbers MG, Stascheit F, Meisel A, Ripke S. Nat Commun. 2024 Nov 13; 2024 Nov 13. PMID: 39537604.
What Are the Genetic Building Blocks of Alcohol-Related Behaviors?Gelernter J, Deak JD. Am J Psychiatry. 2024 Nov 1. PMID: 39482951.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler HR, Stein MB, Gelernter J, Levey DF. Nat Hum Behav. 2024 Nov; 2024 Aug 12. PMID: 39134740.
Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study.Ishrat S, Levey DF, Gelernter J, Ebmeier K, Topiwala A. BMJ Ment Health. 2024 Oct 30; 2024 Oct 30. PMID: 39477366.
Mapping the epigenomic landscape of post-traumatic stress disorder in human cortical neurons.Núñez-Ríos DL, Nagamatsu ST, Martínez-Magaña JJ, Hurd Y, Rompala G, Krystal JH, Montalvo-Ortiz JL. medRxiv. 2024 Oct 16; 2024 Oct 16. PMID: 39484232.
Epigenetic and Genetic Profiling of Comorbidity Patterns among Substance Dependence Diagnoses.Pathak GA, Pietrzak RH, Lacobelle A, Overstreet C, Wendt FR, Deak JD, Friligkou E, Nunez Y, Montalvo-Ortiz JL, Levey DF, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2024 Oct 8; 2024 Oct 8. PMID: 39417130.
Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.He J, Cabrera-Mendoza B, De Angelis F, Pathak GA, Koller D, Curhan SG, Curhan GC, Mecca AP, van Dyck CH, Polimanti R. Brain. 2024 Oct 3. PMID: 38454550.
Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study.Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga MD, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee DS, Pathak GA, Polimanti R. Nat Genet. 2024 Oct; 2024 Sep 18. PMID: 39294497.
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A. Neuropsychopharmacology. 2024 Oct; 2024 Jun 21. PMID: 38906991.
Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.Wang L, Nuñez YZ, Kranzler HR, Zhou H, Gelernter J. medRxiv. 2024 Sep 17; 2024 Sep 17. PMID: 39371181.
Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits.Galimberti M, Levey DF, Deak JD, Zhou H, Stein MB, Gelernter J. Mol Psychiatry. 2024 Sep; 2024 Apr 5. PMID: 38580809.
Association patterns of antisocial personality disorder across substance use disorders.Low A, Stiltner B, Nunez YZ, Adhikari K, Deak JD, Pietrzak RH, Kranzler HR, Gelernter J, Polimanti R. Transl Psychiatry. 2024 Aug 28; 2024 Aug 28. PMID: 39198385.
Genetics of posttraumatic stress disorder and cardiovascular conditions using Life's Essential 8, Electronic Health Records, and Heart Imaging.Shen J, Valentim W, Friligkou E, Overstreet C, Choi K, Koller D, O'Donnell CJ, Stein MB, Gelernter J, Lv H, Sun L, Falcone GJ, Polimanti R, Pathak GA. medRxiv. 2024 Aug 21; 2024 Aug 21. PMID: 39228734.
Human genetics and epigenetics of alcohol use disorder.Zhou H, Gelernter J. J Clin Invest. 2024 Aug 15; 2024 Aug 15. PMID: 39145449.
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach.Cabrera-Mendoza B, Aydin N, Fries GR, Docherty AR, Walss-Bass C, Polimanti R. Neuropsychopharmacology. 2024 Aug; 2024 Feb 23. PMID: 38396255.
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP. Science. 2024 Jul 19; 2024 Jul 19. PMID: 39024449.
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Strom NI, Verhulst B, Bacanu SA, Cheesman R, Purves KL, Gedik H, Mitchell BL, Kwong AS, Faucon AB, Singh K, Medland S, Colodro-Conde L, Krebs K, Hoffmann P, Herms S, Gehlen J, Ripke S, Awasthi S, Palviainen T, Tasanko EM, Peterson RE, Adkins DE, Shabalin AA, Adams MJ, Iveson MH, Campbell A, Thomas LF, Winsvold BS, Drange OK, Børte S, Ter Kuile AR, Nguyen TH, Meier SM, Corfield EC, Hannigan L, Levey DF, Czamara D, Weber H, Choi KW, Pistis G, Couvy-Duchesne B, Van der Auwera S, Teumer A, Karlsson R, Garcia-Argibay M, Lee D, Wang R, Bjerkeset O, Stordal E, Bäckmann J, Salum GA, Zai CC, Kennedy JL, Zai G, Tiwari AK, Heilmann-Heimbach S, Schmidt B, Kaprio J, Kennedy MM, Boden J, Havdahl A, Middeldorp CM, Lopes FL, Akula N, McMahon FJ, Binder EB, Fehm L, Ströhle A, Castelao E, Tiemeier H, Stein DJ, Whiteman D, Olsen C, Fuller Z, Wang X, Wray NR, Byrne EM, Lewis G, Timpson NJ, Davis LK, Hickie IB, Gillespie NA, Milani L, Schumacher J, Woldbye DP, Forstner AJ, Nöthen MM, Hovatta I, Horwood J, Copeland WE, Maes HH, McIntosh AM, Andreassen OA, Zwart JA, Mors O, Børglum AD, Mortensen PB, Ask H, Reichborn-Kjennerud T, Najman JM, Stein MB, Gelernter J, Milaneschi Y, Penninx BW, Boomsma DI, Maron E, Erhardt-Lehmann A, Rück C, Kircher TT, Melzig CA, Alpers GW, Arolt V, Domschke K, Smoller JW, Preisig M, Martin NG, Lupton MK, Luik AI, Reif A, Grabe HJ, Larsson H, Magnusson PK, Oldehinkel AJ, Hartman CA, Breen G, Docherty AR, Coon H, Conrad R, Lehto K, Deckert J, Eley TC, Mattheisen M, Hettema JM. medRxiv. 2024 Jul 5; 2024 Jul 5. PMID: 39006447.
Distinguishing vulnerability and resilience to posttraumatic stress disorder evaluating traumatic experiences, genetic risk and electronic health records.Løkhammer S, Koller D, Wendt FR, Choi KW, He J, Friligkou E, Overstreet C, Gelernter J, Hellard SL, Polimanti R. Psychiatry Res. 2024 Jul; 2024 May 8. PMID: 38744179.
Author Correction: A multi-ancestry genetic study of pain intensity in 598,339 veterans.Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Jul. PMID: 38714900.
Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.Koller D, Friligkou E, Stiltner B, Pathak GA, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Deak JD, Kember RL, Treur JL, Kranzler HR, Johnson EC, Stein MB, Gelernter J, Polimanti R. Mol Psychiatry. 2024 Jul; 2024 Feb 15. PMID: 38355787.
Sex differences in the associations of socioeconomic factors and cognitive performance with family history of Alzheimer's disease.He J, Cabrera-Mendoza B, Friligkou E, Mecca AP, van Dyck CH, Pathak GA, Polimanti R. medRxiv. 2024 Jun 13; 2024 Jun 13. PMID: 38947007.
Genome-wide association study of the common retinal disorder epiretinal membrane: Significant risk loci in each of three American populations.Gelernter J, Levey DF, Galimberti M, Harrington K, Zhou H, Adhikari K, Gupta P, Gaziano JM, Eliott D, Stein MB. Cell Genom. 2024 Jun 12. PMID: 38870908.
Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis.Kowalec K, Harder A, Dolovich C, Fitzgerald KC, Salter A, Lu Y, Bernstein CN, Bolton JM, Cutter G, Fisk JD, Gelernter J, Graff LA, Hägg S, Hitchon CA, Levey DF, Lublin FD, McKay KA, Patten S, Patki A, Stein MB, Tiwari HK, Wolinsky JS, Marrie RA. Ann Clin Transl Neurol. 2024 Jun; 2024 May 7. PMID: 38715244.
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Nat Hum Behav. 2024 Jun; 2024 Apr 17. PMID: 38632388.
Genetic and non-genetic predictors of risk for opioid dependence.Na PJ, Deak JD, Kranzler HR, Pietrzak RH, Gelernter J. Psychol Med. 2024 Jun; 2024 Feb 6. PMID: 38317430.
Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors.Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. medRxiv. 2024 May 28; 2024 May 28. PMID: 38854122.
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babić D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenović AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goleva SB, Gordon SD, Goçi A, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SMJ, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljević M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, Martínez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O'Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdóttir U, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf C, Wolf EJ, Xia Y, Xiong Y, Yehuda R, Young KA, Young RM, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, deRoon-Cassini T, van Rooij SJH, van den Heuvel LL, Stein MB, Ressler KJ, Koenen KC. Nat Genet. 2024 May; 2024 Apr 18. PMID: 38637617.
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. EBioMedicine. 2024 May; 2024 Apr 4. PMID: 38580523.
Unraveling COVID-19 relationship with anxiety disorders and symptoms using genome-wide data.Asgel Z, Kouakou MR, Koller D, Pathak GA, Cabrera-Mendoza B, Polimanti R. J Affect Disord. 2024 May 1; 2024 Feb 19. PMID: 38382819.
The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Cabrera-Mendoza B, Wendt FR, Pathak GA, Yengo L, Polimanti R. Nat Hum Behav. 2024 May; 2024 Feb 16. PMID: 38366106.
Brainwide Mendelian Randomization Study of Anxiety Disorders and Symptoms.Zanoaga MD, Friligkou E, He J, Pathak GA, Koller D, Cabrera-Mendoza B, Stein MB, Polimanti R. Biol Psychiatry. 2024 Apr 15; 2023 Nov 14. PMID: 37967698.
Multi-ancestry Whole-exome Sequencing Study of Alcohol Use Disorder in Two Cohorts.Wang L, Kranzler HR, Gelernter J, Zhou H. medRxiv. 2024 Apr 8; 2024 Apr 8. PMID: 38645055.
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder.Andrade-Brito DE, Núñez-Ríos DL, Martínez-Magaña JJ, Nagamatsu ST, Rompala G, Zillich L, Witt SH, Clark SL, Lattig MC, Montalvo-Ortiz JL. Front Genet. 2024; 2024 Apr 3. PMID: 38633406.
A multi-ancestry genetic study of pain intensity in 598,339 veterans.Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell EE, Pavicic M, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. Nat Med. 2024 Apr; 2024 Mar 1. PMID: 38429522.
Clinical spectrum of Transthyretin amyloidogenic mutations among diverse population origins.De Lillo A, Pathak GA, Low A, De Angelis F, Abou Alaiwi S, Miller EJ, Fuciarelli M, Polimanti R. Hum Genomics. 2024 Mar 25; 2024 Mar 25. PMID: 38523305.
A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases.Lukas E, Veeneman RR, Smit DJ, Vermeulen JM, Pathak GA, Polimanti R, Verweij KJ, Treur JL. medRxiv. 2024 Mar 22; 2024 Mar 22. PMID: 38562880.
Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak JD, Llonga N, Pathak GA, Stiltner B, Løkhammer S, Levey DF, Zhou H, Hatoum AS, Kember RL, Kranzler HR, Stein MB, Corominas R, Demontis D, Artigas MS, Ramos-Quiroga JA, Gelernter J, Ribasés M, Cormand B, Polimanti R. Psychiatry Res. 2024 Mar; 2024 Feb 3. PMID: 38335780.
Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar. PMID: 38182778.
A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices.Valentim WL, Tylee DS, Polimanti R. WIREs Mech Dis. 2024 Mar-Apr; 2023 Dec 7. PMID: 38059513.
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2024 Mar; 2023 Oct 17. PMID: 37848731.
Multi-ancestry tandem repeat association study of hair colour using exome-wide sequencing.Fazzari V, Moo-Choy A, Panoyan MA, Abbatangelo CL, Polimanti R, Novroski NM, Wendt FR. bioRxiv. 2024 Feb 28; 2024 Feb 28. PMID: 38464141.
Whole-exome sequencing in UK Biobank reveals rare genetic architecture for depression.Tian R, Ge T, Kweon H, Rocha DB, Lam M, Liu JZ, Singh K, Levey DF, Gelernter J, Stein MB, Tsai EA, Huang H, Chabris CF, Lencz T, Runz H, Chen CY. Nat Commun. 2024 Feb 26; 2024 Feb 26. PMID: 38409228.
Gene Discovery and Biological Insights into Anxiety Disorders from a Multi-Ancestry Genome-wide Association Study of >1.2 Million Participants.Friligkou E, Løkhammer S, Cabrera-Mendoza B, Shen J, He J, Deiana G, Zanoaga MD, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee DS, Pathak GA, Polimanti R. medRxiv. 2024 Feb 15; 2024 Feb 15. PMID: 38405718.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.Meng X, Navoly G, Giannakopoulou O, Levey DF, Koller D, Pathak GA, Koen N, Lin K, Adams MJ, Rentería ME, Feng Y, Gaziano JM, Stein DJ, Zar HJ, Campbell ML, van Heel DA, Trivedi B, Finer S, McQuillin A, Bass N, Chundru VK, Martin HC, Huang QQ, Valkovskaya M, Chu CY, Kanjira S, Kuo PH, Chen HC, Tsai SJ, Liu YL, Kendler KS, Peterson RE, Cai N, Fang Y, Sen S, Scott LJ, Burmeister M, Loos RJF, Preuss MH, Actkins KV, Davis LK, Uddin M, Wani AH, Wildman DE, Aiello AE, Ursano RJ, Kessler RC, Kanai M, Okada Y, Sakaue S, Rabinowitz JA, Maher BS, Uhl G, Eaton W, Cruz-Fuentes CS, Martinez-Levy GA, Campos AI, Millwood IY, Chen Z, Li L, Wassertheil-Smoller S, Jiang Y, Tian C, Martin NG, Mitchell BL, Byrne EM, Awasthi S, Coleman JRI, Ripke S, Sofer T, Walters RG, McIntosh AM, Polimanti R, Dunn EC, Stein MB, Gelernter J, Lewis CM, Kuchenbaecker K. Nat Genet. 2024 Feb; 2024 Jan 4. PMID: 38177345.
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Johnson EC, Austin-Zimmerman I, Thorpe HH, Levey DF, Baranger DA, Colbert SM, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Forti MD, Sanchez-Roige S, Gelernter J, Agrawal A. medRxiv. 2024 Jan 18; 2024 Jan 18. PMID: 38293235.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology.Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Stein MB, Gelernter J, Levey DF. medRxiv. 2024 Jan 17; 2024 Jan 17. PMID: 38293137.
Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes.Pathak GA, Singh K, Choi KW, Fang Y, Kouakou MR, Lee YH, Zhou X, Fritsche LG, Wendt FR, Davis LK, Polimanti R. JAMA Psychiatry. 2024 Jan 1. PMID: 37910111.
Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million Individuals.Icick R, Shadrin A, Holen B, Karadag N, Parker N, O'Connell K, Frei O, Bahrami S, Høegh M, Lagerberg T, Cheng W, Seibert T, Djurovic S, Dale A, Zhou H, Edenberg H, Gelernter J, Smeland O, Hindley G, Andreassen O. Res Sq. 2023 Dec 22; 2023 Dec 22. PMID: 38196616.
Exome-wide tandem repeats confer large effects on subcortical volumes in UK Biobank participants.Panoyan MA, Shi Y, Abbatangelo CL, Adler N, Moo-Choy A, Parra EJ, Polimanti R, Hu P, Wendt FR. medRxiv. 2023 Dec 11; 2023 Dec 11. PMID: 38168307.
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Justice AC, Stein MB, Kranzler HR, Gelernter J. Nat Med. 2023 Dec; 2023 Dec 7. PMID: 38062264.
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.Levey DF, Galimberti M, Deak JD, Wendt FR, Bhattacharya A, Koller D, Harrington KM, Quaden R, Johnson EC, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal VM, Empke SLL, Zhou H, Nunez YZ, Kranzler HR, Edenberg HJ, Agrawal A, Smoller JW, Lencz T, Hougaard DM, Børglum AD, Demontis D, Gaziano JM, Gandal MJ, Polimanti R, Stein MB, Gelernter J. Nat Genet. 2023 Dec; 2023 Nov 20. PMID: 37985822.
Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders.Li W, Zhou H, Thygesen JH, Heydtmann M, Smith I, Degenhardt F, Nöthen M, Morgan MY, Kranzler HR, Gelernter J, Bass N, McQuillin A. Psychiatr Genet. 2023 Dec 1; 2023 Sep 19. PMID: 37756443.
Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Na P, Zhou H, Montalvo-Ortiz JL, Cabrera-Mendoza B, Petrakis IL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. Psychol Med. 2023 Dec; 2023 Aug 29. PMID: 37642191.
Multi-omics cannot replace sample size in genome-wide association studies.Baranger DAA, Hatoum AS, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Genes Brain Behav. 2023 Dec; 2023 Mar 28. PMID: 36977197.
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder.Andrade-Brito DE, Núñez-Ríos DL, Martínez-Magaña JJ, Nagamatsu ST, Rompala G, Zillich L, Witt SH, Clark SL, Latig MC, Montalvo-Ortiz JL. medRxiv. 2023 Nov 29; 2023 Nov 29. PMID: 38105948.
Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.Sbarra DA, Ramadan FA, Choi KW, Treur JL, Levey DF, Wootton RE, Stein MB, Gelernter J, Klimentidis YC. Mol Psychiatry. 2023 Nov; 2023 Sep 21. PMID: 37735503.
Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment.Ter Kuile AR, Hübel C, Cheesman R, Coleman JRI, Peel AJ, Levey DF, Stein MB, Gelernter J, Rayner C, Eley TC, Breen G. Biol Psychiatry Glob Open Sci. 2023 Oct; 2023 Mar 24. PMID: 37881567.