Selected Publications

Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Transl Psychiatry. 2018 Oct 4;8(1):208. doi: 10.1038/s41398-018-0258-8. PMID: 30287806.

Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated with Opioid Dependence in European Americans. Biol Psychiatry. 2018 Nov 15;84(10):762-770. doi: 10.1016/j.biopsych.2017.12.016. Epub 2018 Jan 11. PMID: 29478698.

Montalvo-Ortiz JL, Zhou H, D'Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Mol Psychiatry. 2018 Jun 6. doi: 10.1038/s41380-018-0077-6. [Epub ahead of print] PMID: 29875475.

Polimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits. Genome Med. 2018 Mar 26;10(1):24. doi: 10.1186/s13073-018-0532-7. PMID: 29580271.

Montalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. Int J Neuropsychopharmacol. 2018 Jan 1;21(1):12-20. doi: 10.1093/ijnp/pyx087. PMID: 29106553.

Zhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated with Comorbid Alcohol Dependence and Major Depression. JAMA Psychiatry. 2017 Dec 1;74(12):1234-1241. doi: 10.1001/jamapsychiatry.2017.3275. PMID: 29071344.

Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clin Exp Res. 2017 Dec;41(12):2025-2032. doi: 10.1111/acer.13516. Epub 2017 Nov 13. PMID: 29131352.

Yang BZ, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex-specific linkage scans in opioid dependence Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):261-268. doi: 10.1002/ajmg.b.32507. Epub 2016 Oct 20. PMID: 27762075.

Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry. 2017 Mar;22(3):346-352. doi: 10.1038/mp.2016.257. Epub 2017 Jan 24. PMID: 28115739.

Polimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genet. 2017 Feb 10;13(2):e1006618. doi: 10.1371/journal.pgen.1006618. eCollection 2017 Feb. PMID: 28187187.

Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036. PMID: 27028160.

Main PubMed Publications

2023

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Nielsen TT, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Justice AC, Stein MB, Kranzler HR, Gelernter J. Nat Med. 2023 Dec 7; 2023 Dec 7. PMID: 38062264.
A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices.Valentim WL, Tylee DS, Polimanti R. WIREs Mech Dis. 2023 Dec 7; 2023 Dec 7. PMID: 38059513.
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.Levey DF, Galimberti M, Deak JD, Wendt FR, Bhattacharya A, Koller D, Harrington KM, Quaden R, Johnson EC, Gupta P, Biradar M, Lam M, Cooke M, Rajagopal VM, Empke SLL, Zhou H, Nunez YZ, Kranzler HR, Edenberg HJ, Agrawal A, Smoller JW, Lencz T, Hougaard DM, Børglum AD, Demontis D, Gaziano JM, Gandal MJ, Polimanti R, Stein MB, Gelernter J. Nat Genet. 2023 Dec; 2023 Nov 20. PMID: 37985822.
Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders.Li W, Zhou H, Thygesen JH, Heydtmann M, Smith I, Degenhardt F, Nöthen M, Morgan MY, Kranzler HR, Gelernter J, Bass N, McQuillin A. Psychiatr Genet. 2023 Dec 1; 2023 Sep 19. PMID: 37756443.
Brain-Wide Mendelian Randomization Study of Anxiety Disorders and Symptoms.Zanoaga MD, Friligkou E, He J, Pathak GA, Koller D, Cabrera-Mendoza B, Stein MB, Polimanti R. Biol Psychiatry. 2023 Nov 13; 2023 Nov 13. PMID: 37967698.
Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes.Pathak GA, Singh K, Choi KW, Fang Y, Kouakou MR, Lee YH, Zhou X, Fritsche LG, Wendt FR, Davis LK, Polimanti R. JAMA Psychiatry. 2023 Nov 1; 2023 Nov 1. PMID: 37910111.
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge.Tamman AJF, Koller D, Nagamastu S, Cabrera-Mendoza B, Abdallah C, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Polimanti R, Pietrzak RH. Neuropsychopharmacology. 2023 Oct 17; 2023 Oct 17. PMID: 37848731.
Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment.Ter Kuile AR, Hübel C, Cheesman R, Coleman JRI, Peel AJ, Levey DF, Stein MB, Gelernter J, Rayner C, Eley TC, Breen G. Biol Psychiatry Glob Open Sci. 2023 Oct; 2023 Mar 24. PMID: 37881567.
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors.Docherty AR, Mullins N, Ashley-Koch AE, Qin X, Coleman JRI, Shabalin A, Kang J, Murnyak B, Wendt F, Adams M, Campos AI, DiBlasi E, Fullerton JM, Kranzler HR, Bakian AV, Monson ET, Rentería ME, Walss-Bass C, Andreassen OA, Behera C, Bulik CM, Edenberg HJ, Kessler RC, Mann JJ, Nurnberger JI Jr, Pistis G, Streit F, Ursano RJ, Polimanti R, Dennis M, Garrett M, Hair L, Harvey P, Hauser ER, Hauser MA, Huffman J, Jacobson D, Madduri R, McMahon B, Oslin DW, Trafton J, Awasthi S, Berrettini WH, Bohus M, Chang X, Chen HC, Chen WJ, Christensen ED, Crow S, Duriez P, Edwards AC, Fernández-Aranda F, Galfalvy H, Gandal M, Gorwood P, Guo Y, Hafferty JD, Hakonarson H, Halmi KA, Hishimoto A, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Kim M, Klump KL, Levey DF, Li D, Liao SC, Lieb K, Lilenfeld L, Marshall CR, Mitchell JE, Okazaki S, Otsuka I, Pinto D, Powers A, Ramoz N, Ripke S, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Starnawska A, Strober M, Su MH, Thornton LM, Treasure J, Ware EB, Watson HJ, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Appadurai V, Artigas MS, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Castelao E, Cervilla JA, Chaumette B, Corvin A, Craddock N, Djurovic S, Foo JC, Forstner AJ, Frye M, Gatt JM, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamshere ML, Hartmann AM, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Krebs MO, Landén M, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Mehta D, Melle I, Mitchell PB, Molina E, Morken G, Nievergelt C, Nöthen MM, O'Donovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribasés M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Trzaskowski M, Tsuang MT, Turecki G, Vilar-Ribó L, Vincent JB, Völzke H, Walters JTR, Weickert CS, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Agerbo E, Børglum AD, Breen G, Demontis D, Erlangsen A, Gelernter J, Glatt SJ, Hougaard DM, Hwu HG, Kuo PH, Lewis CM, Li QS, Liu CM, Martin NG, McIntosh AM, Medland SE, Mors O, Nordentoft M, Olsen CM, Porteous D, Smith DJ, Stahl EA, Stein MB, Wasserman D, Werge T, Whiteman DC, Willour V, Coon H, Beckham JC, Kimbrel NA, Ruderfer DM. Am J Psychiatry. 2023 Oct 1. PMID: 37777856.
Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study.Xu H, Toikumo S, Crist RC, Glogowska K, Jinwala Z, Deak JD, Justice AC, Gelernter J, Johnson EC, Kranzler HR, Kember RL. Addiction. 2023 Oct; 2023 May 22. PMID: 37156939.
Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden.Nichter B, Koller D, De Angelis F, Wang J, Girgenti MJ, Na PJ, Hill ML, Norman SB, Krystal JH, Gelernter J, Polimanti R, Pietrzak RH. Psychol Med. 2023 Oct; 2022 Nov 29. PMID: 36444557.
Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Austin-Zimmerman I, Levey DF, Giannakopoulou O, Deak JD, Galimberti M, Adhikari K, Zhou H, Denaxas S, Irizar H, Kuchenbaecker K, McQuillin A, Concato J, Buysse DJ, Gaziano JM, Gottlieb DJ, Polimanti R, Stein MB, Bramon E, Gelernter J. Nat Commun. 2023 Sep 28; 2023 Sep 28. PMID: 37770476.
Household income does not affect the pleiotropy of schizophrenia genetic liability with mental and physical health outcomes.Kouakou MR, Cabrera-Mendoza B, Pathak GA, Cannon TD, Polimanti R. medRxiv. 2023 Sep 26; 2023 Sep 26. PMID: 37808821.
Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.Sbarra DA, Ramadan FA, Choi KW, Treur JL, Levey DF, Wootton RE, Stein MB, Gelernter J, Klimentidis YC. Mol Psychiatry. 2023 Sep 21; 2023 Sep 21. PMID: 37735503.
Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. medRxiv. 2023 Sep 18; 2023 Sep 18. PMID: 37034728.
Association Patterns of Antisocial Personality Disorder across Substance Use Disorders.Low A, Stiltner B, Nunez YZ, Adhikari K, Deak JD, Pietrzak RH, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2023 Sep 15; 2023 Sep 15. PMID: 37745497.
Brain-Wide Mendelian Randomization Study of Anxiety Disorders and Symptoms.Zanoaga MD, Friligkou E, He J, Pathak GA, Koller D, Cabrera-Mendoza B, Stein MB, Polimanti R. medRxiv. 2023 Sep 13; 2023 Sep 13. PMID: 37745546.
Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders.Nievergelt CM, Maihofer AX, Atkinson EG, Chen CY, Choi KW, Coleman JR, Daskalakis NP, Duncan LE, Polimanti R, Aaronson C, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegoviç E, Babic D, Bacanu SA, Baker DG, Batzler A, Beckham JC, Belangero S, Benjet C, Bergner C, Bierer LM, Biernacka JM, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Brandolino A, Breen G, Bressan RA, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Bækvad-Hansen M, Børglum AD, Børte S, Cahn L, Calabrese JR, Caldas-de-Almeida JM, Chatzinakos C, Cheema S, Clouston SAP, Colodro-Conde L, Coombes BJ, Cruz-Fuentes CS, Dale AM, Dalvie S, Davis LK, Deckert J, Delahanty DL, Dennis MF, deRoon-Cassini T, Desarnaud F, DiPietro CP, Disner SG, Docherty AR, Domschke K, Dyb G, Kulenovic AD, Edenberg HJ, Evans A, Fabbri C, Fani N, Farrer LA, Feder A, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goci A, Goleva SB, Gordon SD, Grasser LR, Guindalini C, Haas M, Hagenaars S, Hauser MA, Heath AC, Hemmings SM, Hesselbrock V, Hickie IB, Hogan K, Hougaard DM, Huang H, Huckins LM, Hveem K, Jakovljevic M, Javanbakht A, Jenkins GD, Johnson J, Jones I, Jovanovic T, Karstoft KI, Kaufman ML, Kennedy JL, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kotov R, Kranzler HR, Krebs K, Kremen WS, Kuan PF, Lawford BR, Lebois LAM, Lehto K, Levey DF, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lu Y, Luft BJ, Lupton MK, Luykx JJ, Makotkine I, Maples-Keller JL, Marchese S, Marmar C, Martin NG, MartÍnez-Levy GA, McAloney K, McFarlane A, McLaughlin KA, McLean SA, Medland SE, Mehta D, Meyers J, Michopoulos V, Mikita EA, Milani L, Milberg W, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Mufford MS, Nelson EC, Nordentoft M, Norman SB, Nugent NR, O'Donnell M, Orcutt HK, Pan PM, Panizzon MS, Pathak GA, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Porjesz B, Powers A, Qin XJ, Ratanatharathorn A, Risbrough VB, Roberts AL, Rothbaum BO, Rothbaum AO, Roy-Byrne P, Ruggiero KJ, Rung A, Runz H, Rutten BPF, de Viteri SS, Salum GA, Sampson L, Sanchez SE, Santoro M, Seah C, Seedat S, Seng JS, Shabalin A, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stensland S, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Tiwari AK, Trapido E, Uddin M, Ursano RJ, Valdimarsdóttir U, van den Heuvel LL, Van Hooff M, van Rooij SJ, Vermetten E, Vinkers CH, Voisey J, Wang Z, Wang Y, Waszczuk M, Weber H, Wendt FR, Werge T, Williams MA, Williamson DE, Winsvold BS, Winternitz S, Wolf EJ, Wolf C, Xia Y, Xiong Y, Yehuda R, Young RM, Young KA, Zai CC, Zai GC, Zervas M, Zhao H, Zoellner LA, Zwart JA, Stein MB, Ressler KJ, Koenen KC. medRxiv. 2023 Sep 2; 2023 Sep 2. PMID: 37693460.
Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Na P, Zhou H, Montalvo-Ortiz JL, Cabrera-Mendoza B, Petrakis IL, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. Psychol Med. 2023 Aug 29; 2023 Aug 29. PMID: 37642191.
Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation.He J, Cabrera-Mendoza B, Angelis F, Pathak GA, Koller D, Curhan SG, Curhan GC, Mecca AP, van Dyck CH, Polimanti R. medRxiv. 2023 Aug 28; 2023 Aug 28. PMID: 37693474.
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder.Stiltner B, Pietrzak RH, Tylee DS, Nunez YZ, Adhikari K, Kranzler HR, Gelernter J, Polimanti R. iScience. 2023 Aug 18; 2023 Jul 16. PMID: 37554454.
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach.Cabrera-Mendoza B, Aydin N, Fries GR, Docherty AR, Walss-Bass C, Polimanti R. medRxiv. 2023 Aug 16; 2023 Aug 16. PMID: 37645805.
Integrating Genome-wide information and Wearable Device Data to Explore the Link of Anxiety and Antidepressants with Heart Rate Variability.Friligkou E, Koller D, Pathak GA, Miller EJ, Lampert R, Stein MB, Polimanti R. medRxiv. 2023 Aug 4; 2023 Aug 4. PMID: 37577704.
Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample.Kember RL, Vickers-Smith R, Zhou H, Xu H, Jennings M, Dao C, Davis L, Sanchez-Roige S, Justice AC, Gelernter J, Vujkovic M, Kranzler HR. Am J Psychiatry. 2023 Aug 1; 2023 Jun 7. PMID: 37282553.
Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders.Koller D, Benítez-Burraco A, Polimanti R. Hum Genet. 2023 Aug; 2023 Mar 17. PMID: 36930228.
Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis.D'Antona S, Pathak GA, Koller D, Porro D, Cava C, Polimanti R. Hum Genet. 2023 Aug; 2023 Feb 11. PMID: 36773064.
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex.Rompala G, Nagamatsu ST, Martínez-Magaña JJ, Nuñez-Ríos DL, Wang J, Girgenti MJ, Krystal JH, Gelernter J, Hurd YL, Montalvo-Ortiz JL. Nat Commun. 2023 Jul 28; 2023 Jul 28. PMID: 37507366.
Unraveling COVID-19 Relationship with Anxiety Disorders and Symptoms.Asgel Z, Kouakou MR, Koller D, Pathak GA, Cabrera-Mendoza B, Polimanti R. medRxiv. 2023 Jul 23; 2023 Jul 23. PMID: 37503035.
Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent.De Lillo A, Wendt FR, Pathak GA, Polimanti R. Hum Genomics. 2023 Jul 20; 2023 Jul 20. PMID: 37475089.
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses.Als TD, Kurki MI, Grove J, Voloudakis G, Therrien K, Tasanko E, Nielsen TT, Naamanka J, Veerapen K, Levey DF, Bendl J, Bybjerg-Grauholm J, Zeng B, Demontis D, Rosengren A, Athanasiadis G, Bækved-Hansen M, Qvist P, Bragi Walters G, Thorgeirsson T, Stefánsson H, Musliner KL, Rajagopal VM, Farajzadeh L, Thirstrup J, Vilhjálmsson BJ, McGrath JJ, Mattheisen M, Meier S, Agerbo E, Stefánsson K, Nordentoft M, Werge T, Hougaard DM, Mortensen PB, Stein MB, Gelernter J, Hovatta I, Roussos P, Daly MJ, Mors O, Palotie A, Børglum AD. Nat Med. 2023 Jul; 2023 Jul 18. PMID: 37464041.
Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent alcohol use and parental alcohol use disorder.Wang FL, Hicks BM, Zhou H, Kranzler HR, Gelernter J, Zucker RA. Drug Alcohol Depend. 2023 Jul 1; 2023 Apr 29. PMID: 37163864.
Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F, Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Sun YV, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao PS, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano MJ, Madduri RK, Damrauer SM, Liao KP. medRxiv. 2023 Jun 29; 2023 Jun 29. PMID: 37425708.
Characterizing the polygenic architecture of complex traits in populations of East Asian and European descent.De Lillo A, Wendt FR, Pathak GA, Polimanti R. medRxiv. 2023 Jun 3; 2023 Jun 3. PMID: 37398225.
Modeling the longitudinal changes of ancestry diversity in the Million Veteran Program.Wendt FR, Pathak GA, Vahey J, Qin X, Koller D, Cabrera-Mendoza B, Haeny A, Harrington KM, Rajeevan N, Duong LM, Levey DF, De Angelis F, De Lillo A, Bigdeli TB, Pyarajan S, Gaziano JM, Gelernter J, Aslan M, Provenzale D, Helmer DA, Hauser ER, Polimanti R. Hum Genomics. 2023 Jun 2; 2023 Jun 2. PMID: 37268996.
Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.Colbert SMC, Wendt FR, Pathak GA, Helmer DA, Hauser ER, Keller MC, Polimanti R, Johnson EC. Am J Hum Genet. 2023 Jun 1; 2023 May 12. PMID: 37178685.
Sex differences in the polygenic architecture of hearing problems in adults.De Angelis F, Zeleznik OA, Wendt FR, Pathak GA, Tylee DS, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford RE, Maihofer AX, Nievergelt CM, Curhan GC, Curhan SG, Polimanti R. Genome Med. 2023 May 11; 2023 May 11. PMID: 37165447.
Multi-trait genome-wide association analyses leveraging alcohol use disorder findings identify novel loci for smoking behaviors in the Million Veteran Program.Cheng Y, Dao C, Zhou H, Li B, Kember RL, Toikumo S, Zhao H, Gelernter J, Kranzler HR, Justice AC, Xu K. Transl Psychiatry. 2023 May 5; 2023 May 5. PMID: 37147289.
Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study.Na PJ, Montalvo-Ortiz J, Petrakis I, Krystal JH, Polimanti R, Gelernter J, Pietrzak RH. Drug Alcohol Depend. 2023 May 1; 2023 Mar 6. PMID: 36963160.
Decoding the role of transcriptomic clocks in the human prefrontal cortex.Martínez-Magaña JJ, Krystal JH, Girgenti MJ, Núnez-Ríos DL, Nagamatsu ST, Andrade-Brito DE, Montalvo-Ortiz JL. medRxiv. 2023 Apr 25; 2023 Apr 25. PMID: 37163025.
Multi-omics cannot replace sample size in genome-wide association studies.Baranger DAA, Hatoum AS, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Genes Brain Behav. 2023 Mar 28; 2023 Mar 28. PMID: 36977197.
Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.Kember RL, Hartwell EE, Xu H, Rotenberg J, Almasy L, Zhou H, Gelernter J, Kranzler HR. Biol Psychiatry. 2023 Mar 15; 2022 Aug 18. PMID: 36273948.
The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans.Toikumo S, Vickers-Smith R, Jinwala Z, Xu H, Saini D, Hartwell E, Venegas MP, Sullivan KA, Xu K, Jacobson DA, Gelernter J, Rentsch CT, Stahl E, Cheatle M, Zhou H, Waxman SG, Justice AC, Kember RL, Kranzler HR. medRxiv. 2023 Mar 13; 2023 Mar 13. PMID: 36993749.
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Nat Ment Health. 2023 Mar; 2023 Mar 22. PMID: 37250466.
Functional and molecular characterization of suicidality factors using phenotypic and genome-wide data.Quintero Reis A, Newton BA, Kessler R, Polimanti R, Wendt FR. Mol Psychiatry. 2023 Mar; 2023 Jan 6. PMID: 36604601.
Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Psychol Med. 2023 Mar; 2021 Jul 7. PMID: 34231451.
The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.Wendt FR, Garcia-Argibay M, Cabrera-Mendoza B, Valdimarsdóttir UA, Gelernter J, Stein MB, Nivard MG, Maihofer AX, Nievergelt CM, Larsson H, Mattheisen M, Polimanti R, Meier SM. Biol Psychiatry. 2023 Feb 15; 2022 Aug 24. PMID: 36335070.
Polysubstance addiction and psychiatric, somatic comorbidities among 7,989 individuals with cocaine use disorder: a latent class analysis.Stiltner B, Pietrzak RH, Tylee DS, Nunez YZ, Adhikari K, Kranzler HR, Gelernter J, Polimanti R. medRxiv. 2023 Feb 10; 2023 Feb 10. PMID: 36798273.
Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review.Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Krystal JH, Martínez-González KG, Giusti-Rodríguez P, Montalvo-Ortiz JL. Complex Psychiatry. 2023 Jan-Dec; 2023 Feb 3. PMID: 37404872.
Sex-Specific Genetic and Transcriptomic Liability to Neuroticism.Wendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Biol Psychiatry. 2023 Feb 1; 2022 Aug 5. PMID: 36244801.
Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans.Tamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Am J Geriatr Psychiatry. 2023 Feb; 2022 Sep 10. PMID: 36210262.
Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals.Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Justice AC, Stein MB, Kranzler HR, Gelernter J. medRxiv. 2023 Jan 30; 2023 Jan 30. PMID: 36747741.
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders.Koller D, Pathak GA, Wendt FR, Tylee DS, Levey DF, Overstreet C, Gelernter J, Taylor HS, Polimanti R. JAMA Netw Open. 2023 Jan 3; 2023 Jan 3. PMID: 36652249.
Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort.Nagamatsu ST, Pietrzak RH, Xu K, Krystal JH, Gelernter J, Montalvo-Ortiz JL. Addict Biol. 2023 Jan. PMID: 36577721.
Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants.Overstreet C, Levey DF, Zhou H, Harrington KM, Quaden R, Stein MB, Gelernter J, Pietrzak RH. Psychiatry Res. 2023 Jan; 2022 Nov 28. PMID: 36516638.

2022

CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder.Nagamatsu ST, Rompala G, Hurd YL, Núñez-Rios DL, Montalvo-Ortiz JL. Front Psychiatry. 2022; 2023 Jan 19. PMID: 36745154.
Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes.Wendt FR, Pathak GA, Polimanti R. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509785.
Exploring the genetic overlap between twelve psychiatric disorders.Romero C, Werme J, Jansen PR, Gelernter J, Stein MB, Levey D, Polimanti R, de Leeuw C, Posthuma D, Nagel M, van der Sluis S. Nat Genet. 2022 Dec; 2022 Dec 5. PMID: 36471075.
A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality.Verma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Petersen JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung AM, O'Donnell CJ, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW. Am J Respir Crit Care Med. 2022 Nov 15. PMID: 35771531.
Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology.Lam M, Chen CY, Hill WD, Xia C, Tian R, Levey DF, Gelernter J, Stein MB, Hatoum AS, Huang H, Malhotra AK, Runz H, Ge T, Lencz T. Nat Commun. 2022 Nov 11; 2022 Nov 11. PMID: 36369282.
Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations.Koller D, Wendt FR, Pathak GA, De Lillo A, De Angelis F, Cabrera-Mendoza B, Tucci S, Polimanti R. BMC Biol. 2022 Nov 7; 2022 Nov 7. PMID: 36344982.
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.Lynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Nat Commun. 2022 Oct 15; 2022 Oct 15. PMID: 36243721.
The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study.Cabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. Int J Epidemiol. 2022 Oct 13. PMID: 35751636.
Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Gaddis N, Mathur R, Marks J, Zhou L, Quach B, Waldrop A, Levran O, Agrawal A, Randesi M, Adelson M, Jeffries PW, Martin NG, Degenhardt L, Montgomery GW, Wetherill L, Lai D, Bucholz K, Foroud T, Porjesz B, Runarsdottir V, Tyrfingsson T, Einarsson G, Gudbjartsson DF, Webb BT, Crist RC, Kranzler HR, Sherva R, Zhou H, Hulse G, Wildenauer D, Kelty E, Attia J, Holliday EG, McEvoy M, Scott RJ, Schwab SG, Maher BS, Gruza R, Kreek MJ, Nelson EC, Thorgeirsson T, Stefansson K, Berrettini WH, Gelernter J, Edenberg HJ, Bierut L, Hancock DB, Johnson EO. Sci Rep. 2022 Oct 7; 2022 Oct 7. PMID: 36207451.
Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.Deak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J. JAMA Netw Open. 2022 Oct 3; 2022 Oct 3. PMID: 36301540.
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT, Davis LK, Justice AC, Sanchez-Roige S, Kampman KM, Gelernter J, Kranzler HR. Nat Neurosci. 2022 Oct; 2022 Sep 28. PMID: 36171425.
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O'Donnell CJ, Assimes TL, Stein MB, Gelernter J. Mol Psychiatry. 2022 Oct; 2022 Aug 19. PMID: 35986173.
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Mol Psychiatry. 2022 Oct; 2022 Jul 25. PMID: 35879402.
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects.Topiwala A, Taschler B, Ebmeier KP, Smith S, Zhou H, Levey DF, Codd V, Samani NJ, Gelernter J, Nichols TE, Burgess S. Mol Psychiatry. 2022 Oct; 2022 Jul 26. PMID: 35879401.
Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function.Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR. Neuropsychopharmacology. 2022 Sep; 2022 May 11. PMID: 35545664.
Genome-wide meta-analysis of alcohol use disorder in East Asians.Zhou H, Kalayasiri R, Sun Y, Nuñez YZ, Deng HW, Chen XD, Justice AC, Kranzler HR, Chang S, Lu L, Shi J, Sanichwankul K, Mutirangura A, Malison RT, Gelernter J. Neuropsychopharmacology. 2022 Sep; 2022 Jan 29. PMID: 35094024.
The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates.Hatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Neuropsychopharmacology. 2022 Sep; 2021 Nov 8. PMID: 34750568.
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D. Nat Genet. 2022 Aug; 2022 Jul 14. PMID: 35835914.
Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait.Verma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O'Donnell CJ, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW. JAMA Intern Med. 2022 Aug 1. PMID: 35759254.
Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses.Topiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, Zhou H, McCracken C, Roca-Fernández A, Petersen SE, Raman B, Husain M, Gelernter J, Miller KL, Smith SM, Nichols TE. PLoS Med. 2022 Jul; 2022 Jul 14. PMID: 35834561.
Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. J Clin Psychiatry. 2022 Jul 6; 2022 Jul 6. PMID: 35802930.
An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes.Tylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. JAMA Psychiatry. 2022 Jul 1. PMID: 35507366.
Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder.Wingo TS, Gerasimov ES, Liu Y, Duong DM, Vattathil SM, Lori A, Gockley J, Breen MS, Maihofer AX, Nievergelt CM, Koenen KC, Levey DF, Gelernter J, Stein MB, Ressler KJ, Bennett DA, Levey AI, Seyfried NT, Wingo AP. Mol Psychiatry. 2022 Jul; 2022 Apr 21. PMID: 35449297.
The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression.Pathak GA, De Lillo A, Wendt FR, De Angelis F, Koller D, Cabrera Mendoza B, Jacoby D, Miller EJ, Buxbaum JN, Polimanti R. Amyloid. 2022 Jun; 2021 Dec 22. PMID: 34935565.
Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence.Núñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Biomedicines. 2022 May 10; 2022 May 10. PMID: 35625844.
A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program.Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, Pyarajan S, Bick AG, Costa L, Genovese G, Hauger R, Madduri R, Pathak GA, Polimanti R, Voight B, Vujkovic M, Zekavat SM, Zhao H, Ritchie MD, Chang KM, Cho K, Casas JP, Tsao PS, Gaziano JM, O'Donnell C, Damrauer SM, Liao KP. PLoS Genet. 2022 Apr; 2022 Apr 28. PMID: 35482673.
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder.Wendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Mol Psychiatry. 2022 Apr; 2022 Feb 18. PMID: 35181757.
APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program.Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O'Donnell CJ, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED. JAMA Intern Med. 2022 Apr 1. PMID: 35089317.
Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study.Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Biol Psychiatry. 2022 Apr 1; 2021 Oct 6. PMID: 34955171.
Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.Maihofer AX, Choi KW, Coleman JRI, Daskalakis NP, Denckla CA, Ketema E, Morey RA, Polimanti R, Ratanatharathorn A, Torres K, Wingo AP, Zai CC, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegović E, Borglum AD, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Chen CY, Dale AM, Dalvie S, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Duncan LE, Džubur Kulenović A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gautam A, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goçi A, Gordon SD, Guffanti G, Hammamieh R, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljević M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller JL, Marmar C, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, Mehta D, Mellor R, Michopoulos V, Milberg W, Miller MW, Morris CP, Mors O, Mortensen PB, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Yehuda R, Young KA, Young RM, Zhao H, Zoellner LA, Haas M, Lasseter H, Provost AC, Salem RM, Sebat J, Shaffer RA, Wu T, Ripke S, Daly MJ, Ressler KJ, Koenen KC, Stein MB, Nievergelt CM. Biol Psychiatry. 2022 Apr 1; 2021 Sep 28. PMID: 34865855.
Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events.Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Neurobiol Stress. 2022 Mar; 2022 Feb 21. PMID: 35242894.
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits.Pathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O' Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Mol Psychiatry. 2022 Mar; 2022 Mar 3. PMID: 35241783.
Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans.Montalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak RH. Transl Psychiatry. 2022 Feb 17; 2022 Feb 17. PMID: 35177594.
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.Mullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, Levey DF, Lori A, Shabalin A, Starnawska A, Su MH, Watson HJ, Adams M, Awasthi S, Gandal M, Hafferty JD, Hishimoto A, Kim M, Okazaki S, Otsuka I, Ripke S, Ware EB, Bergen AW, Berrettini WH, Bohus M, Brandt H, Chang X, Chen WJ, Chen HC, Crawford S, Crow S, DiBlasi E, Duriez P, Fernández-Aranda F, Fichter MM, Gallinger S, Glatt SJ, Gorwood P, Guo Y, Hakonarson H, Halmi KA, Hwu HG, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Klump KL, Li D, Liao SC, Lieb K, Lilenfeld L, Liu CM, Magistretti PJ, Marshall CR, Mitchell JE, Monson ET, Myers RM, Pinto D, Powers A, Ramoz N, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Strober M, Thornton LM, Treasure J, Tsuang MT, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Air TM, Alda M, Alfredsson L, Andreassen OA, Anjorin A, Appadurai V, Soler Artigas M, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Bosch R, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Casas M, Castelao E, Cervilla JA, Chaumette B, Cichon S, Corvin A, Craddock N, Craig D, Degenhardt F, Djurovic S, Edenberg HJ, Fanous AH, Foo JC, Forstner AJ, Frye M, Fullerton JM, Gatt JM, Gejman PV, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamilton SP, Hamshere ML, Hartmann A, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Konte B, Krebs MO, Landén M, Lawrence J, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Lucae S, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Medland SE, Mehta D, Melle I, Milaneschi Y, Mitchell PB, Molina E, Morken G, Mortensen PB, Müller-Myhsok B, Nievergelt C, Nimgaonkar V, Nöthen MM, O'Donovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Pimm J, Pistis G, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribasés M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Rujescu D, Sánchez-Mora C, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Shyn SI, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Spalletta G, Strauss JS, Świątkowska B, Trzaskowski M, Turecki G, Vilar-Ribó L, Vincent JB, Völzke H, Walters JTR, Shannon Weickert C, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Ashley-Koch AE, Beckham JC, Hauser ER, Hauser MA, Kimbrel NA, Lindquist JH, McMahon B, Oslin DW, Qin X, Agerbo E, Børglum AD, Breen G, Erlangsen A, Esko T, Gelernter J, Hougaard DM, Kessler RC, Kranzler HR, Li QS, Martin NG, McIntosh AM, Mors O, Nordentoft M, Olsen CM, Porteous D, Ursano RJ, Wasserman D, Werge T, Whiteman DC, Bulik CM, Coon H, Demontis D, Docherty AR, Kuo PH, Lewis CM, Mann JJ, Rentería ME, Smith DJ, Stahl EA, Stein MB, Streit F, Willour V, Ruderfer DM. Biol Psychiatry. 2022 Feb 1; 2021 Sep 9. PMID: 34861974.
Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans.Na PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Mol Psychiatry. 2022 Feb; 2021 Nov 2. PMID: 34725455.

2021

CYP2D6 Genetic Variation and Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis.Wannasuphoprasit Y, Andersen SE, Arranz MJ, Catalan R, Jurgens G, Kloosterboer SM, Rasmussen HB, Bhat A, Irizar H, Koller D, Polimanti R, Wang B, Zartaloudi E, Austin-Zimmerman I, Bramon E. Front Psychol. 2021; 2022 Feb 3. PMID: 35185676.
Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent.Wendt FR, De Lillo A, Pathak GA, De Angelis F, Polimanti R. Front Genet. 2021; 2021 Dec 13. PMID: 34966408.
Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example.Hatoum AS, Wendt FR, Galimberti M, Polimanti R, Neale B, Kranzler HR, Gelernter J, Edenberg HJ, Agrawal A. Drug Alcohol Depend. 2021 Dec 1; 2021 Oct 9. PMID: 34710714.
Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA).Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Drug Alcohol Depend. 2021 Dec 1; 2021 Sep 24. PMID: 34710713.
Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.Asch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. World J Biol Psychiatry. 2021 Dec; 2021 May 20. PMID: 33821766.
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk.De Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Transl Psychiatry. 2021 Nov 13; 2021 Nov 13. PMID: 34775470.
Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition.Muniz Carvalho C, Wendt FR, Pathak GA, Maihofer AX, Stein DJ, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Neurobiol Stress. 2021 Nov; 2021 Sep 17. PMID: 34611531.
Genetics of substance use disorders in the era of big data.Gelernter J, Polimanti R. Nat Rev Genet. 2021 Nov; 2021 Jul 1. PMID: 34211176.
The relationship between cannabis and schizophrenia: a genetically informed perspective.Johnson EC, Hatoum AS, Deak JD, Polimanti R, Murray RM, Edenberg HJ, Gelernter J, Di Forti M, Agrawal A. Addiction. 2021 Nov; 2021 May 19. PMID: 33950550.
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