Robert Ostroff, MD
About
Research
Publications
2024
Blood pressure changes during ketamine infusion for the treatment of depression
Ansari M, Pittman B, Tylee D, Ostroff R, Wilkinson S, Nikayin S. Blood pressure changes during ketamine infusion for the treatment of depression. General Hospital Psychiatry 2024, 90: 62-67. PMID: 38991311, DOI: 10.1016/j.genhosppsych.2024.07.001.Peer-Reviewed Original ResearchKetamine infusionBlood pressure changesBlood pressureRetrospective chart review of patientsChart review of patientsMedical history of hypertensionRetrospective chart reviewHistory of hypertensionSignificant blood pressureDiastolic blood pressureTreatment of depressionSevere hypertensionPatient demographicsHypertensive patientsInfusion sessionsMedical historyHypertensive eventsInfusionPatientsKetamineBP surgeCardiovascular monitoringBloodHypertensionPressure changesKetamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha M, Wilkinson S, Krishnan K, Collins K, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew S, Anand A. Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression. JAMA Network Open 2024, 7: e2417786. PMID: 38916891, PMCID: PMC11200139, DOI: 10.1001/jamanetworkopen.2024.17786.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionQIDS-SR16 scoresElectroconvulsive therapy groupElectroconvulsive therapyQIDS-SR16Measure of premorbid intelligencePosttraumatic stress disorder diagnosisTrial of electroconvulsive therapyNonpsychotic depressive episodeImpaired memory recallAssociated with differential improvementStress disorder diagnosisIntravenous ketamineEnd-of-treatment visitInfusion of ketamineMADRS scorePremorbid intelligenceResistant depressionDepressive episodeMeasures mixed-effects modelsFalse discovery rate adjustmentDisorder diagnosisMemory recallSevere depressionDifferential improvement
2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
Anand A, Mathew S, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Collins K, Costi S, Iqbal S, Jha M, Krishnan K, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wilkinson S, Wolski K, Hu B. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal Of Medicine 2023, 388: 2315-2325. PMID: 37224232, DOI: 10.1056/nejmoa2302399.Peer-Reviewed Original ResearchConceptsTreatment-resistant major depressionPatient-reported qualityElectroconvulsive therapyMajor depressionECT groupKetamine groupTreatment phaseMusculoskeletal adverse effectsSubanesthetic intravenous ketamineWeeks of treatmentInitial treatment phaseIntravenous ketamineSecondary outcomesPrimary outcomeNoninferiority marginTrial groupECT clinicsNoninferiority trialPatientsComparative effectivenessKetamineClinical sitesAdverse effectsDepressionThree times
2019
Interventional psychiatry, a new competency for 21st century psychiatry residents
Ostroff R, Kitay B, Wilkinson S, Taylor J. Interventional psychiatry, a new competency for 21st century psychiatry residents. Brain Stimulation 2019, 12: 475. DOI: 10.1016/j.brs.2018.12.547.Peer-Reviewed Original ResearchClinical factors contributing to morbidity, mortality, and cost in patients requiring ECT for the management of catatonia
Kitay B, Ostroff R. Clinical factors contributing to morbidity, mortality, and cost in patients requiring ECT for the management of catatonia. Brain Stimulation 2019, 12: 462. DOI: 10.1016/j.brs.2018.12.503.Peer-Reviewed Original ResearchAdjustment of pulse wave parameters to optimize effective ect treatment
Ostroff R, Kitay B. Adjustment of pulse wave parameters to optimize effective ect treatment. Brain Stimulation 2019, 12: 385. DOI: 10.1016/j.brs.2018.12.229.Peer-Reviewed Case Reports and Technical Notes
2018
The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion
Kitay B, Katz R, Wilkinson S, Ostroff R. The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion. Journal Of Ect 2018, 1. DOI: 10.1097/00124509-900000000-99225.Peer-Reviewed Original ResearchErratum to: Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.Commentaries, Editorials and LettersS106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital
Wilkinson S, Webler R, Katz R, Toprak M, Ostroff R, Sanacora G. S106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital. Biological Psychiatry 2018, 83: s388. DOI: 10.1016/j.biopsych.2018.02.997.Peer-Reviewed Original ResearchThe Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders
Ostroff R, Katz R. The Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders. Current Treatment Options In Psychiatry 2018, 5: 228-241. DOI: 10.1007/s40501-018-0144-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUse of ECTElectroconvulsive therapyTreatment of depressionMovement disordersDepressed Elderly (PRIDE) studySevere psychiatric illnessLife-saving treatmentWarrants further investigationProlonging RemissionPharmacologic treatmentGeriatric patientsElderly StudyClinical algorithmDementia syndromesPsychiatric illnessEffective treatmentParkinson's diseaseElderly populationPsychiatric disordersAge groupsTherapyRemissionTreatmentBehavioral dysregulationDisorders
Clinical Care
Overview
Clinical Specialties
Psychiatry
Board Certifications
Psychiatry
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 1982
Links & Media
News
- March 20, 2023
Six Psychiatry Faculty Recognized by Class of 2023
- January 02, 2022Source: Journal of the Neurological Sciences
Nikayin, Ostroff: Advanced Training in Interventional Psychiatry
- July 31, 2018Source: Biological Psychiatry
Acute and longer-term outcomes using ketamine as a clinical treatment at the Yale Psychiatric Hospital
- May 07, 2018
Residents, fellows, faculty contribute to book '50 Studies Every Psychiatrist Should Know'