Philip Corlett, PhD
Cards
About
Titles
Associate Professor of Psychiatry
Biography
Dr. Philip Robert Corlett trained in Experimental Psychology, Cognitive Neuroscience and Psychiatry with Professors Trevor Robbins and Paul Fletcher at the University of Cambridge. He won a Wellcome Trust Prize Studentship and completed his PhD on the brain bases of delusion formation in the Brain Mapping Unit, Department of Psychiatry. After a short postdoc, he was awarded the University of Cambridge Parke- Davis Exchange Fellowship in Biomedical Sciences which brought him to the Yale University Department of Psychiatry to explore the maintenance of delusions with Professors Jane Taylor and John Krystal. He was named a Rising Star and Future Opinion Leader by Pharmaceutical Marketing Magazine and joined the Yale faculty in 2011 where he will continue to explore the cognitive and biological mechanisms of delusional beliefs as well as predictive learning, habit formation and addiction.
Appointments
Psychiatry
Associate Professor TenurePrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Center for the Translational Neuroscience of Alcohol
- Clinical Neuroscience Research Unit
- Connecticut Mental Health Center
- Interdepartmental Neuroscience Program
- Neural Disorders
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Psychiatry
- Psychology Section
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Global Mental Health Program
- Yale Ventures
Education & Training
- PhD
- University of Cambridge (2006)
Research
Publications
2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionUnderstanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework
Sheffield J, Brinen A, Feola B, Heckers S, Corlett P. Understanding Cognitive Behavioral Therapy for Psychosis Through the Predictive Coding Framework. Biological Psychiatry Global Open Science 2024, 4: 100333. PMID: 38952435, PMCID: PMC11215207, DOI: 10.1016/j.bpsgos.2024.100333.Peer-Reviewed Original ResearchCognitive behavioral therapyPersecutory delusionsBehavioral therapyMaintenance of delusionsSymptoms of psychosisAssociative learning modelsCognitive-behavioral interventionsPrediction error signalsLevels of information processingPredictive coding frameworkHierarchical predictive codingPredictive codingPsychotic disordersPsychological treatmentCognitive neurosciencePsychological processesCBTpPsychosisDelusionsBelief updatingInformation processingAlternative beliefsNeuroscienceProcess theoryComputational neuroscienceBelief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders
Sloan A, Kittleson A, Torregrossa L, Feola B, Rossi-Goldthorpe R, Corlett P, Sheffield J. Belief Updating, Childhood Maltreatment, and Paranoia in Schizophrenia-Spectrum Disorders. Schizophrenia Bulletin 2024, sbae057. PMID: 38701234, DOI: 10.1093/schbul/sbae057.Peer-Reviewed Original ResearchSchizophrenia spectrum disordersExposure to childhood maltreatmentPositive and Negative Syndrome ScaleChildhood Trauma QuestionnaireChildhood maltreatmentHierarchical Gaussian FilterBelief updatingProbabilistic reversal learningNegative Syndrome ScaleSyndrome ScaleNonpsychiatric controlsReversal learningSchizophrenia spectrumCumulative maltreatmentTrauma QuestionnaireDeprivation exposureGreen et al.ParanoiaConferring riskMaltreatmentPrior expectationsDisordersIndirect effectsChildhoodBeliefsLongitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode
Sheffield J, Hall L, Vandekar S, Liu J, Woodward N, Heckers S, Corlett P. Longitudinal Associations Between Belief Updating and Delusions in Individuals Recovering From an Acute Psychotic Episode. Biological Psychiatry 2024, 95: s66-s67. DOI: 10.1016/j.biopsych.2024.02.164.Peer-Reviewed Original Research11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions
Huque Z, O'Brien K, Rossi-Goldthorpe R, Kenney J, Mittal V, Strauss G, Walker E, Schiffman J, Woods S, Powers A, Silverstein S, Waltz J, Gold J, Corlett P, Ellman L. 11. Role of Prediction Errors in the Relationship Between Ethnoracial Discrimination and Delusions. Biological Psychiatry 2024, 95: s78-s79. DOI: 10.1016/j.biopsych.2024.02.189.Peer-Reviewed Original ResearchDifferent learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, awae122. PMID: 38637303, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoiaImagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunctionIllusory generalizability of clinical prediction models
Chekroud A, Hawrilenko M, Loho H, Bondar J, Gueorguieva R, Hasan A, Kambeitz J, Corlett P, Koutsouleris N, Krumholz H, Krystal J, Paulus M. Illusory generalizability of clinical prediction models. Science 2024, 383: 164-167. PMID: 38207039, DOI: 10.1126/science.adg8538.Peer-Reviewed Original ResearchDelusions and the Predictive Mind
Bongiorno F, Corlett P. Delusions and the Predictive Mind. Australasian Journal Of Philosophy 2024, ahead-of-print: 1-16. DOI: 10.1080/00048402.2023.2293825.Peer-Reviewed Original Research
2023
Assessing the impact of a comprehensive mental health program on frontline health service workers
Ward E, Fragala M, Birse C, Hawrilenko M, Smolka C, Ambwani G, Brown M, Krystal J, Corlett P, Chekroud A. Assessing the impact of a comprehensive mental health program on frontline health service workers. PLOS ONE 2023, 18: e0294414. PMID: 37988363, PMCID: PMC10662717, DOI: 10.1371/journal.pone.0294414.Peer-Reviewed Original ResearchConceptsMental health benefitsSheehan Disability ScaleHealth service workersMental health issuesHealth benefitsHealth issuesRetrospective cohort studyPHQ-9 scaleMental health screeningComprehensive mental health programGAD-7 scaleMental health programsCare navigationCohort studyHealth screeningDisability ScaleMedication managementTreatment appointmentsFunctional impairmentLeast moderate anxietyHealth services companyOutcome assessmentHealth programsModerate anxietyAnxiety symptoms
Clinical Trials
Current Trials
Song-making In a Group (SING)
HIC ID2000026376RolePrincipal InvestigatorPrimary Completion Date08/31/2024Recruiting ParticipantsPredictive Coding and Unusual Experiences
HIC ID2000021858RolePrincipal InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18 years - 55 yearsTeen Brain and Behavior Study
HIC ID1111009332RoleSub InvestigatorPrimary Completion Date12/21/2022Recruiting ParticipantsGenderBothAge13 years - 17 years
Academic Achievements and Community Involvement
Links & Media
News
- June 14, 2024Source: YaleNews
New Insights Into the Brain Regions Involved in Paranoia
- June 05, 2024
Four Faculty Invited to Speak at Cold Spring Harbor's 2024 Schizophrenia and Related Disorders Course
- May 24, 2024Source: STAT
After MDMA Therapy, She Considered Suicide. The Trial Data Tell a Different Story
- January 12, 2024Source: Yale News
Quest for Personalized Medicine Hits a Snag