2022
Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy
Schurgers G, Walter S, Pishva E, Guloksuz S, Peerbooms O, Incio L, Arts B, Kenis G, Rutten B. Longitudinal alterations in mRNA expression of the BDNF neurotrophin signaling cascade in blood correlate with changes in depression scores in patients undergoing electroconvulsive therapy. European Neuropsychopharmacology 2022, 63: 60-70. PMID: 36067540, DOI: 10.1016/j.euroneuro.2022.07.183.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsBrain-Derived Neurotrophic FactorDepressionElectroconvulsive TherapyEpigenesis, GeneticHumansRNA, MessengerConceptsBrain-derived neurotrophic factorBDNF/TrkBExpression of BDNFSerum BDNF protein levelsBDNF protein levelsElectroconvulsive therapyDepression scoresMRNA expressionPeripheral bloodTreatment-resistant depressed patientsProtein levelsMechanism of actionAntidepressant effectsNeurotrophic factorDepressed patientsLongitudinal alterationsSevere depressionBlood correlatesEffective treatmentLongitudinal changesTrkBStudy periodNR3C1PatientsTherapy
2017
DNA Methylation in Schizophrenia
Pries L, Gülöksüz S, Kenis G. DNA Methylation in Schizophrenia. Advances In Experimental Medicine And Biology 2017, 978: 211-236. PMID: 28523549, DOI: 10.1007/978-3-319-53889-1_12.Peer-Reviewed Original ResearchConceptsAberrant DNA modificationsGenome-wide approachesDNA methylation changesCandidate gene studiesHigh heritability estimatesGenetic susceptibility lociHeritable psychiatric conditionEpigenetic mechanismsDNA methylationEpigenetic processesMethylation changesDNA modificationsComplex phenotypesGene studiesSusceptibility lociHeritability estimatesRelevant environmental risk factors