Sinan Guloksuz, MD, PhD
About
Research
Publications
2025
Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.
Andreu-Bernabeu Á, González-Peñas J, Mora A, Bernardo M, Mezquida G, Amoretti S, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Santos J, Jiménez-López E, Arrojo M, Carracedo A, Parellada M, Maric N, Atbaşoğlu C, Üçok A, Alptekin K, Saka M, Pries L, O'Donovan M, van Os J, Rutten B, Delespaul P, Guloksuz S, Arango C, Díaz-Caneja C. Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study. The British Journal Of Psychiatry 2025, 1-9. PMID: 40519115, DOI: 10.1192/bjp.2025.100.Peer-Reviewed Original ResearchGene-environment interactionsGenetic riskSchizophrenia spectrum disordersAdverse mental health outcomesGenetic liabilityAssociated with higher oddsPolygenic risk scoresIdentification of high-risk individualsMental health outcomesRelative excess riskHigh-risk individualsEU-GEILogistic regression modelsHealth outcomesExcess riskHigher oddsPrevention strategiesVulnerable populationsRisk scoreRegression modelsLonelinessEarly identificationLong-term effectsWorsening symptomsAssociated with psychosisDecision-making on an AI-supported youth mental health app: A multilogue among ethicists, social scientists, AI-researchers, biomedical engineers, young experiential experts, and psychiatrists
Horstkötter D, Kanne M, Karbouniaris S, Lazrak N, Bulgheroni M, Sheltawy E, Giani L, La Gamba M, Pujadas E, Camacho M, Royle F, Baggetto I, Gülöksüz S, Rutten B, van Os J. Decision-making on an AI-supported youth mental health app: A multilogue among ethicists, social scientists, AI-researchers, biomedical engineers, young experiential experts, and psychiatrists. Journal Of Responsible Technology 2025, 22: 100119. DOI: 10.1016/j.jrt.2025.100119.Peer-Reviewed Original ResearchYouth mental health careMental health careMental health appsMental health expertsHealth appsHealth careSocial scientistsDecision-makingEthical challengesDecision-making processImpact of AIHealth expertsAI developmentHuman decision-makingPsychiatristsEthicistsTransdisciplinary teamFunding phaseDocument analysisExpertsTeam of researchersCareDecisionHuman relationshipsMultilogueMinimum data standards for schizophrenia and the EnvironmenT (MINDSET) research harmonization exercise
Crossley N, Gülöksüz S. Minimum data standards for schizophrenia and the EnvironmenT (MINDSET) research harmonization exercise. Schizophrenia Research 2025, 281: 216-217. PMID: 40398099, DOI: 10.1016/j.schres.2025.05.009.Peer-Reviewed Original ResearchDissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study
Lin B, Li Y, Goula A, Chang X, Grasby K, Medland S, Andreassen O, Rutten B, Guloksuz S, van der Meer D, Luykx J. Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. Nature Mental Health 2025, 3: 613-625. DOI: 10.1038/s44220-025-00397-4.Peer-Reviewed Original ResearchMean cortical thicknessCognitive performanceCortical morphologySchizophrenia riskBrain cortical surface areaEffects of cognitive performanceCortical surface areaImproving brain healthCortical morphological measuresNeuropsychiatric disordersNeuropsychiatric phenotypesBidirectional associationsBrain healthSchizophreniaNeuropsychiatric traitsCortical thicknessGlobal mean cortical thicknessSmoking initiationPositive causal effectTemporal thicknessInvestigate causal linksCausal effectsBrainCausal linkIntervention studiesSocial and mental health pathways to institutional trust: A cohort study
Paquin V, Miconi D, Aversa S, Johnson-Lafleur J, Côté S, Geoffroy M, Gülöksüz S. Social and mental health pathways to institutional trust: A cohort study. Social Science & Medicine 2025, 379: 118199. PMID: 40382867, DOI: 10.1016/j.socscimed.2025.118199.Peer-Reviewed Original ResearchConceptsFactor associated with lower levelsMental health factorsSocial connectednessHealth factorsMental healthContext of mental health problemsMental health pathwayQuebec Longitudinal Study of Child DevelopmentLongitudinal Study of Child DevelopmentEarly-life factorsLower household incomeMental health problemsSocio-economic disadvantageHistory of depressionAssociated with greater trustPromote social connectednessStudy of Child DevelopmentPsychotic experiencesAssociated with institutional trustHealth pathwaysRacial minority statusPerceived stressProfessional helpMaternal history of depressionEarly lifeDo psychotic symptoms predict future psychotic disorders in adolescent psychiatry inpatients? A 17-year cohort study
Kieseppä V, Lång U, Healy C, O’Hare K, Díaz-Caneja C, Gülöksüz S, Rutten B, Cannon M, Halt A, Riipinen P, Kelleher I. Do psychotic symptoms predict future psychotic disorders in adolescent psychiatry inpatients? A 17-year cohort study. Psychological Medicine 2025, 55: e108. PMID: 40176435, PMCID: PMC12094655, DOI: 10.1017/s003329172500073x.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum disordersSubthreshold psychotic symptomsPsychotic symptomsAdolescent psychiatry inpatientsPsychiatry inpatientsSchedule for Affective DisordersNon-psychotic mental disordersRisk of schizophrenia spectrum disordersBaseline psychotic symptomsPsychiatric inpatient admissionsInpatient admissionsPsychiatric inpatient careIncreased riskNational health care registersHealth care usePsychotic disordersAffective disordersHealth care registersMental disordersCare registersCare useInpatient careDisordersFollow-upCox regressionIndependent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry
Di Vincenzo M, Prachason T, Sampogna G, Arias-Magnasco A, Lin B, Pries L, van Os J, Rutten B, Barzilay R, Fiorillo A, Guloksuz S. Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry. Schizophrenia 2025, 11: 26. PMID: 39984505, PMCID: PMC11845623, DOI: 10.1038/s41537-025-00569-2.Peer-Reviewed Original ResearchRisk due to interactionDistressing psychotic experiencesExcess risk due to interactionPsychotic experiencesEuropean ancestryMultilevel logistic regression modelsPolygenic risk scoresAdditive interactionStrength of associationLogistic regression modelsEarly adolescenceJoint associationsExposome scoreIncreasing strength of associationSecondary outcomesRisk scorePrimary outcomeRegression modelsStudy dataAdolescent brainSchizophreniaAdolescentsFollow-upJoint effectsOutcomesInternational perspectives on physician knowledge, attitudes, and practices related to medical cannabis
Syed S, Singh J, Elkholy H, Palavra I, Tomicevic M, Eric A, da Costa M, Guloksuz S, Radhakrishnan R. International perspectives on physician knowledge, attitudes, and practices related to medical cannabis. Frontiers In Public Health 2025, 13: 1463871. PMID: 40051509, PMCID: PMC11882600, DOI: 10.3389/fpubh.2025.1463871.Peer-Reviewed Original ResearchConceptsPhysicians' knowledgeStrength of evidenceMedical cannabisCross-sectional survey of physiciansSurvey of physiciansCross-sectional surveyYears of clinical experienceNegative health outcomesCannabis useClinical experienceRefractory chronic neuropathic painClinical decision-makingHealth outcomesPhysicians' attitudesPhysicians' willingnessChronic neuropathic painMedical use of cannabisRisk of psychosisDaily cannabis useMedication useDescriptive statisticsRisk of addictionMedical indicationsUse of cannabisPhysiciansExposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank
Lin B, Pries L, Arias-Magnasco A, Klingenberg B, Linden D, Blokland G, van der Meer D, Luykx J, Rutten B, Guloksuz S. Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank. Biological Psychiatry Global Open Science 2025, 5: 100460. PMID: 40206033, PMCID: PMC11981733, DOI: 10.1016/j.bpsgos.2025.100460.Peer-Reviewed Original ResearchGene-by-environment interactionsPRS-SCZUK BiobankExposome-wide association studyPsychotic experiencesPolygenic risk scoresAssociated with psychotic experiencesMental distressRisk scoreAssociation studiesSleep problemsBiobankAdditive interactionPsychosis riskAgnostic analysisCorrelation testXWASGenetic vulnerabilityDistressParticipantsScoresCorrelation analysisExposureStudyRiskMapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants
Arias-Magnasco A, Lin B, Pries L, Guloksuz S. Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants. Psychological Medicine 2025, 55: e16. PMID: 39917825, PMCID: PMC11968124, DOI: 10.1017/s0033291724003015.Peer-Reviewed Original ResearchConceptsMental health phenotypesMental health outcomesExposome-wide association studySymptom dimensionsDiagnostic domainsCommon psychiatric disordersHealth phenotypesHealth outcomesEarly life experiencesMental Health SurveyImproving mental well-beingMental health frameworkAssociation studiesUK Biobank participantsCannabis usePsychiatric disordersEating disordersChildhood adversityPublic health policiesTraumatic eventsMental well-beingMultivariate modelDifferential associationsNeurodevelopmental disordersMental health