2024
The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking
Le T, Oba T, Couch L, McInerney L, Li C. The Neural Correlates of Individual Differences in Reinforcement Learning during Pain Avoidance and Reward Seeking. ENeuro 2024, 11: eneuro.0437-23.2024. PMID: 38365840, PMCID: PMC10901196, DOI: 10.1523/eneuro.0437-23.2024.Peer-Reviewed Original ResearchConceptsSuperior frontal gyrusReward-seekingCingulate cortexNeural correlatesPain avoidanceAction biasDorsal anterior cingulate cortexLeft posterior cingulate cortexAction-outcome associationsGo/No-Go taskAnterior cingulate cortexPosterior cingulate cortexImpact of outcomesHigher learning rateReward trialsFrontal gyrusAvoidance learningMidcingulate cortexNeural substratesAssociative learningAction tendenciesPre-SMAAssociated with activationPrecentral gyrusPostcentral gyrus
2023
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problemsAppetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers
Chen Y, Li C. Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers. Addiction Neuroscience 2023, 7: 100089. PMID: 37483686, PMCID: PMC10358306, DOI: 10.1016/j.addicn.2023.100089.Peer-Reviewed Original ResearchCue responsesMonetary incentive delay taskDistinct neural correlatesDistinct neural underpinningsIncentive delay taskNegative emotional statesMid-cingulate cortexMedial cortical regionsDrug cuesNeural underpinningsCue reactivityNeural correlatesSubjective urgeAlcohol expectanciesDelay taskEmotional statesLoss processingSensation seekingVentral striatumAlcohol drinkersAversive componentCortical regionsAversive responsesSubstance misusePotential subtypes
2022
Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking
Chen Y, Dhingra I, Le T, Zhornitsky S, Zhang S, Li C. Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking. Brain Sciences 2022, 12: 1689. PMID: 36552149, PMCID: PMC9775947, DOI: 10.3390/brainsci12121689.Peer-Reviewed Original ResearchSuperior temporal gyrusMonetary incentive delay taskAlcohol Use Disorders Identification TestParahippocampal gyrusAlcohol misuseNeural correlatesReward processingWhole-brain regressionAltered reward processingIncentive delay taskDepression InventoryBDI-II scoresRight parahippocampal gyrusAlcohol use disorderDelay taskDisorders Identification TestLoss processingTemporal gyrusFrontoparietal regionsNeural markersBeck Depression InventoryDrinking adultsMediation analysisProblem drinkingSeverity of drinkingShared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task
Chen Y, Chaudhary S, Li C. Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task. NeuroImage 2022, 264: 119764. PMID: 36427755, PMCID: PMC9837714, DOI: 10.1016/j.neuroimage.2022.119764.Peer-Reviewed Original ResearchConceptsSupplementary motor areaMonetary incentive delay taskMedial orbitofrontal cortexBilateral anterior insulaLoss outcomesAnterior insulaLoss anticipationIncentive delay taskBilateral striatumPrecentral gyrusCingulate cortexBilateral medial orbitofrontal cortexDorsal anterior cingulate cortexRight occipital cortexDelay taskAnterior cingulate cortexPosterior cingulate cortexNeural correlatesActivation likelihood estimationRight thalamusMotor areaOccipital cortexRegional activityDistinct neural activityStriatumEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemory
2021
Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention
Li G, Chen Y, Tang X, Li CR. Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention. Journal Of Psychiatric Research 2021, 142: 302-311. PMID: 34416549, PMCID: PMC8429210, DOI: 10.1016/j.jpsychires.2021.08.018.Peer-Reviewed Original ResearchConceptsPittsburgh Sleep Quality IndexNeural correlatesAlcohol useSleep disturbancesReaction timeSustained visual attentionAlcohol misuseWhole-brain regressionGreater sleep disturbanceHuman Connectome ProjectSevere alcohol useVisual attentionSustained attentionNeural processesCognitive performanceLow accuracy rateLonger reaction timesPerformance accuracyConnectome ProjectNeural correlates of individual variation in two-back working memory and the relationship with fluid intelligence
Li G, Chen Y, Le TM, Wang W, Tang X, Li CR. Neural correlates of individual variation in two-back working memory and the relationship with fluid intelligence. Scientific Reports 2021, 11: 9980. PMID: 33976306, PMCID: PMC8113462, DOI: 10.1038/s41598-021-89433-8.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexN-back performanceRight anterior insulaStandard Progressive Matrices testFluid intelligenceNeural correlatesReaction timePre-supplementary motor areaRaven's Standard Progressive Matrices testN-back taskIndividual variationHuman Connectome Project datasetProgressive Matrices TestProlonged response timeBilateral frontoparietal cortexAnterior cingulate cortexTwo-backNeural basisDorsal precuneusRSPM performanceNeural processesNeural substratesAnterior insulaCerebral correlatesCorrect itemsPerceived friendship and binge drinking in young adults: A study of the Human Connectome Project data
Li G, Chen Y, Le TM, Zhornitsky S, Wang W, Dhingra I, Zhang S, Tang X, Li CR. Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data. Drug And Alcohol Dependence 2021, 224: 108731. PMID: 33915512, PMCID: PMC8641247, DOI: 10.1016/j.drugalcdep.2021.108731.Peer-Reviewed Original ResearchConceptsNon-binge drinkersRight posterior insulaPeer influenceYoung adult binge drinkingSocial cognition tasksSocial cognitive processingAlcohol useBinge drinkingWhole-brain regressionAdult binge drinkingYoung adultsMedial orbitofrontal cortexHuman Connectome ProjectRPI activityAlcohol use severityHuman Connectome Project dataSocial cognitionCognition tasksCognitive processingNeural correlatesNeural processesPotential sex differencesOrbitofrontal cortexPosterior insulaConnectome Project
2020
Gray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data
Ide JS, Li HT, Chen Y, Le TM, Li CSP, Zhornitsky S, Li CR. Gray matter volumetric correlates of behavioral activation and inhibition system traits in children: An exploratory voxel-based morphometry study of the ABCD project data. NeuroImage 2020, 220: 117085. PMID: 32592852, PMCID: PMC7572877, DOI: 10.1016/j.neuroimage.2020.117085.Peer-Reviewed Original ResearchConceptsBehavioral activation systemBehavioral inhibition systemGray matter volumeHigher BAS scoresVentral striatumBAS scoresInhibition systemBIS scoresInferior frontal cortexFundamental behavioral traitsTwins/siblingsRight anterior insulaHigher BIS scoresNeural correlatesDevelopmental neuroscienceAnterior insulaVolumetric correlatesVoxel-based morphometry studyInternalizing psychopathologyCerebral basisVoxel-based morphometryBehavioral activationVentral caudateAvoidance traitsMatter volume
2019
Neural correlates of reward-directed action and inhibition of action
Le TM, Zhang S, Zhornitsky S, Wang W, Li CR. Neural correlates of reward-directed action and inhibition of action. Cortex 2019, 123: 42-56. PMID: 31747630, DOI: 10.1016/j.cortex.2019.10.007.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexInhibition of actionGo trialsReward-directed actionGoal-directed actionsInferior parietal cortexMiddle frontal cortexAnterior cingulate cortexMain effectSignificant main effectVisual attentionNeural correlatesGo taskResponse executionReward valuationNeural processesBrain activationHealthy human adultsNeural responsesReward magnitudeConjunction analysisLarge rewardDorsal ACCCingulate cortexParietal cortexInterdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action
Le TM, Wang W, Zhornitsky S, Dhingra I, Zhang S, Li CR. Interdependent Neural Correlates of Reward and Punishment Sensitivity During Rewarded Action and Inhibition of Action. Cerebral Cortex 2019, 30: 1662-1676. PMID: 31667492, PMCID: PMC7132903, DOI: 10.1093/cercor/bhz194.Peer-Reviewed Original ResearchConceptsInhibition of actionNeural correlatesReinforcement Sensitivity TheoryRostral anterior cingulate cortexMiddle frontal gyrusAnterior cingulate cortexPunishment sensitivityReinforcement sensitivityMFG activityIndividual differencesNeural processesReward QuestionnaireTrait sensitivityBrain correlatesNeural substratesFrontal gyrusGo responseRewarded actionsSensitivity theoryIncorrect responsesMediation analysisCingulate cortexRegional activationBehavioral approachAvoidance behaviorNeural correlates of enhanced response inhibition in the aftermath of stress
Chang J, Hu J, Li CR, Yu R. Neural correlates of enhanced response inhibition in the aftermath of stress. NeuroImage 2019, 204: 116212. PMID: 31546050, PMCID: PMC7509808, DOI: 10.1016/j.neuroimage.2019.116212.Peer-Reviewed Original ResearchConceptsInhibitory controlAcute stressMagnetic resonance imaging studySignal taskResonance imaging studyFunctional magnetic resonance imaging studyMiddle frontal gyrusTrier Social Stress TestControl conditionSignal reaction timeAftermath of stressSocial Stress TestImaging studiesCognitive functionDynamic causal modelingStress exposureEnhanced response inhibitionPilot studyFrontal gyrusLife stressNeural mechanismsStriatumResponse inhibitionNeural correlatesImmediate effectsCue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers
Wang W, Zhornitsky S, Le TM, Dhingra I, Zhang S, Krystal JH, Li CR. Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. Journal Of Psychiatric Research 2019, 116: 74-82. PMID: 31202048, PMCID: PMC6606341, DOI: 10.1016/j.jpsychires.2019.06.005.Peer-Reviewed Original ResearchConceptsSkin conductance responsesPhysiological arousalThalamic activityNeural processesNeutral cue exposureMediation analysisHigher skin conductance responsesCue exposure paradigmCue-related activationsCue-elicited cravingCue-elicited drugNon-dependent drinkersImportant sex differencesSkin conductance dataPharmacological therapyAlcohol drinkersNeural targetsAlcohol cravingExposure paradigmCue exposureNeural correlatesNeural basisConductance responsesWomenCue activitySocial anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game
Wang W, Zhornitsky S, Li CS, Le TM, Joormann J, Li CR. Social anxiety, posterior insula activation, and autonomic response during self-initiated action in a Cyberball game. Journal Of Affective Disorders 2019, 255: 158-167. PMID: 31153052, PMCID: PMC6591038, DOI: 10.1016/j.jad.2019.05.046.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsPosterior insula activationSocial anxietyCyberball gameInsula activationPhysiological arousalHigher skin conductance responsesHigh social anxietySevere social anxietyHigher physiological arousalSkin conductance responsesSkin conductance dataPotential sex effectsEffect of depressionSocial exclusionInsula responseNeural correlatesNeural processesLA individualsConductance responsesLimbic activationRegional activationSkin conductanceAnxietyLA groupCerebral responses to self-initiated action during social interactions
Wang W, Zhornitsky S, Li C, Zhang S, Ide JS, Joormann J, Li CR. Cerebral responses to self-initiated action during social interactions. Cognitive, Affective, & Behavioral Neuroscience 2019, 19: 1521-1535. PMID: 30941709, PMCID: PMC6774916, DOI: 10.3758/s13415-019-00711-5.Peer-Reviewed Original ResearchConceptsSelf-initiated actionsSocial interactionSocial communication needsSocial behavioral disordersPosterior cortical activationSocial exclusionHealthy adultsMind processingCyberball gameSocial anxietySocial emotionsNeural correlatesPercentage of trialsSubjective awarenessAngular gyrusNeural markersCortical activationCortical activityBall tossBehavioral disordersCerebral responsesFuture researchCommunication needsExtant studiesOwn volitionNeural correlates of chemotherapy-induced emotion regulation impairment in breast cancer patients.
Gan C, Lv Y, Zhao J, Chao HH, Li CR, Zhang C, Yu F, Cheng H. Neural correlates of chemotherapy-induced emotion regulation impairment in breast cancer patients. American Journal Of Cancer Research 2019, 9: 171-179. PMID: 30755820, PMCID: PMC6356929.Peer-Reviewed Original Research
2017
Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field
Ide JS, Tung HC, Yang CT, Tseng YC, Li CR. Barratt Impulsivity in Healthy Adults Is Associated with Higher Gray Matter Concentration in the Parietal Occipital Cortex that Represents Peripheral Visual Field. Frontiers In Human Neuroscience 2017, 11: 222. PMID: 28522966, PMCID: PMC5415556, DOI: 10.3389/fnhum.2017.00222.Peer-Reviewed Original ResearchGray matter volumeGray matter concentrationPeripheral visual fieldOccipital cortexBarratt impulsivityVisual fieldYoung adultsPrefrontal cortical areasParietal-occipital cortexHigher impulsivity scoresMotor subscoresCortical volumeCortical areasMatter volumeCerebral structuresHealthy adultsClinical importanceHealthy populationNeuropsychiatric conditionsFrontal dysfunctionAlcohol useImpulsive individualsAdultsImpulsivity scoresNeural correlates
2015
Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence
Hu S, Ide JS, Zhang S, Li CS. Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence. NeuroImage 2015, 119: 286-295. PMID: 26095091, PMCID: PMC4564311, DOI: 10.1016/j.neuroimage.2015.06.032.Peer-Reviewed Original ResearchConceptsProactive controlMedial prefrontal cortexNeural correlatesPrefrontal cortexPre-supplementary motor areaTrial reaction timeStop-signal taskBilateral anterior insulaProlonged response timeReaction timeMotor consequencesCognitive controlConflict anticipationRT slowingSignal taskAnterior insulaTarget onsetLarge fMRI data setsPrediction errorBehavioral paradigmsBehavioral consequencesGranger causality analysisFMRI data setsBayesian beliefFMRI signalsConflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task
Hu S, Ide JS, Zhang S, Sinha R, Li CS. Conflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task. NeuroImage Clinical 2015, 8: 39-50. PMID: 26106526, PMCID: PMC4473266, DOI: 10.1016/j.nicl.2015.03.008.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeHealthy control individualsConflict anticipationAlcohol dependenceCognitive controlProactive controlSignal taskSequential effectsModel-based fMRI studyAlcohol consumptionStop signalPre-supplementary motor areaBilateral inferior parietal cortexPerigenual anterior cingulate cortexSignificant sequential effectInferior parietal cortexSignal reaction timeWhole-brain responsesAnterior cingulate cortexRecent alcohol consumptionNeural correlatesFMRI studyNeural markersMotor areaTrial onset