Gretchen Hermes, MD, PhD

Assistant Professor

Public Health Interests

Aging; Chronic disease management; Depression; HIV/AIDS; Psychological Trauma; Schizophrenia

Research Organizations

Psychiatry: Addictions, Division of | Neuroscience Research Training Program (NRTP)

Selected Publications

  • Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation Gretchen Hermes, David Nagy, Michael Waterson, Attila Zsarnovszky, Luis Varela, Mihaly Hajos, Tamas L. Horvath, Molecular Metabolism, Published online: April 8 2016.
  • Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of homeostasis and behavior. Hermes, G. and Gao, XB. Frontiers in Systems Neuroscience. 2015 Oct 21;9:142.
  • UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior.

    Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PloS One 2012, 7:e42911.

  • Hermes, G., Li, N., Duman, C. and R. Duman, Post-weaning chronic social isolation produces significant behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein and glutamate receptor expression in female rats. Physiology and Behavior, Special Issue on Stress, 2010, 104(2011): 354-359.
  • Social isolation dysregulates stress and behavioral responses and increases the burden and malignancy of spontaneous mammary tumors.

    Gretchen L. Hermes, Bertha Delgado, Maria Tretiakova, Sonia A. Cavigelli, Thomas Krausz, Suzanne D. Conzen, and Martha K. McClintock. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52): 22393–22398.

  • Hermes, G, James W Ajioka, Krystyna A Kelly, Ernest Mui, Fiona Roberts, Kristen Kasza, Thomas Mayr, Michael J Kirisits, Robert Wollman, David Ferguson, Craig W Roberts, Jong-Hee Hwang, Toria Trendler, Richard P Kennan, Yasuhiro Suzuki, Catherine Reardon, Adam W Hickey, Lieping Chen and Rima McLeod. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection. Journal of Neuroinflammation, 2008,5:48.
  • Hermes, G. and M. K. McClintock. Isolation and the timing of mammary gland development, gonadarche, and estropause: implications for mammary tumor burden. Developmental Psychobiology, 2007, 50(4):353-60.
  • Hermes, G. Rosenthal, L. Montag, A. and M.K. McClintock. Social isolation and the inflammatory response: Sex differences in the enduring effects of a prior stressor. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2006, 290:R273-R282.
  • Hermes, G., Jacobs, L. and M. K. McClintock. A novel foraging field to quantify spatial cognition, learning, and memory (2005). Neurobiology of Learning and Memory, 84(1):69-73
  • Emotions and Disease Exhibtion Catalog
  • Hermes, Gretchen and Gerard Sanacora, "Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence from Preclinical Studies." In Ketamine for Treatment-Resistant Depression: The First Decade of Progress, eds. Sanjay J. Mathew and Carlos A. Zarate Jr. Springer International Publishing, 2016.

Edit this profile

Contact Info

Gretchen Hermes, MD, PhD
Patient Care Location
Yale Depression Research Program100 York Street, Ste 2J
New Haven, CT 06511
View on map...
Lab Location
Horvath LabBrady Memorial Laboratory
310 Cedar Street, Ste 416

New Haven, CT 06510
View on map...
Mailing Address
Psychiatry2 Church St S
New Haven, CT 06519