Jonas Christian Schupp, MD

Assistant Professor Adjunct

Research & Publications
Biography
News

Coauthors

Selected Publications

Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjectsLiu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. Correction: iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 394. PMID: 37858060, PMCID: PMC10588114, DOI: 10.1186/s12859-023-05523-6.
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells.Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.
When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic DisordersSchupp J, Kaminski N. When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 652-654. PMID: 37555730, PMCID: PMC10515565, DOI: 10.1164/rccm.202307-1271ed.
Morphomolecular analysis of the capillary network in alveolar capillary dysplasiaKamp J, Neubert L, Schupp J, Wrede C, Laenger F, Welte T, Schwerk N, Reichmann J, Salditt T, Bergmann A, Von Hardenberg S, Kreipe H, Olsson K, Fuge J, Park D, Hoeper M, Jonigk D, Knudsen L, Kuehnel M. Morphomolecular analysis of the capillary network in alveolar capillary dysplasia. 2023, oa4942. DOI: 10.1183/13993003.congress-2023.oa4942.
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjectsLiu Y, Zhao J, Adams T, Wang N, Schupp J, Wu W, McDonough J, Chupp G, Kaminski N, Wang Z, Yan X. iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects. BMC Bioinformatics 2023, 24: 318. PMID: 37608264, PMCID: PMC10463720, DOI: 10.1186/s12859-023-05432-8.
Lung endothelium, tau, and amyloids in health and diseaseBalczon R, Lin M, Voth S, Nelson A, Schupp J, Wagener B, Pittet J, Stevens T. Lung endothelium, tau, and amyloids in health and disease. Physiological Reviews 2023, 104: 533-587. PMID: 37561137, DOI: 10.1152/physrev.00006.2023.
Genetic and geographic influence on phenotypic variation in European sarcoidosis patientsFreitag-Wolf S, Schupp J, Frye B, Fischer A, Anwar R, Kieszko R, Mihailović-Vučinić V, Milanowski J, Jovanovic D, Zissel G, Bargagli E, Rottoli P, Bumbacea D, Jonkers R, Ho L, Gaede K, Dubaniewicz A, Marshall B, Günther A, Petrek M, Keane M, Haraldsdottir S, Bonella F, Grah C, Peroš-Golubičić T, Kadija Z, Pabst S, Grohé C, Strausz J, Safrankova M, Millar A, Homolka J, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Dempfle A, Müller-Quernheim J. Genetic and geographic influence on phenotypic variation in European sarcoidosis patients. Frontiers In Medicine 2023, 10: 1218106. PMID: 37621457, PMCID: PMC10446882, DOI: 10.3389/fmed.2023.1218106.
Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertensionOlsson K, Fuge J, Park D, Kamp J, Brod T, Harrigfeld B, Schupp J, Hoeper M. Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension. European Respiratory Journal 2023, 62: 2301070. PMID: 37474157, DOI: 10.1183/13993003.01070-2023.
Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling.Yanagihara T, Tsubouchi K, Zhou Q, Chong M, Otsubo K, Isshiki T, Schupp J, Sato S, Scallan C, Upagupta C, Revill S, Ayoub A, Chong S, Dvorkin-Gheva A, Kaminski N, Tikkanen J, Keshavjee S, Paré G, Guignabert C, Ask K, Kolb M. Vascular-Parenchymal Cross-Talk Promotes Lung Fibrosis through BMPR2 Signaling. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 1498-1514. PMID: 36917778, DOI: 10.1164/rccm.202109-2174oc.
Calcineurin-inhibitor free immunosuppression after lung transplantation – a single center case-control study in 51 patients converted to Mechanistic Target of Rapamycin (mTOR) inhibitorsGottlieb J, Fischer B, Schupp J, Golpon H. Calcineurin-inhibitor free immunosuppression after lung transplantation – a single center case-control study in 51 patients converted to Mechanistic Target of Rapamycin (mTOR) inhibitors. PLOS ONE 2023, 18: e0284653. PMID: 37200246, PMCID: PMC10194991, DOI: 10.1371/journal.pone.0284653.
Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
Fibrotic Cocktail Treated Human Precision Lung Slices Replicate the Cellular Diversity of the IPF LungJustet A, Pineda R, Adams T, Balayev A, Mitash N, Ishizuka M, Kim H, Cala Garcia J, Flint J, Schupp J, Ahangari F, Yan X, Rosas I, Koenigshoff M. Fibrotic Cocktail Treated Human Precision Lung Slices Replicate the Cellular Diversity of the IPF Lung. 2023, a4698-a4698. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4698.
Aberrant Basaloid Cells and Closely Connected Intermediate State Cells Are Involved in the Injury Repair Process of the Fibrotic Lungs in the Aftermath of Severe COVID-19Balayev A, Adams T, Justet A, Schupp J, Mcdonough J, Kaminski N. Aberrant Basaloid Cells and Closely Connected Intermediate State Cells Are Involved in the Injury Repair Process of the Fibrotic Lungs in the Aftermath of Severe COVID-19. 2023, a5667-a5667. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a5667.
Spatial Transcriptomic Analysis Allow the Identification of Abnormal Airway Niches in the Fibrotic LungJustet A, Adams T, Balayev A, Baernthaler T, Poli F, Cala Garcia J, Mcdonough J, Flint J, Schupp J, Zhao A, Yunqing L, Ningshan L, Raredon M, Lepe A, Wang A, Abu Hussein N, Yan X, Rosas I, Kaminski N. Spatial Transcriptomic Analysis Allow the Identification of Abnormal Airway Niches in the Fibrotic Lung. 2023, a1033-a1033. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1033.
Online Cell Atlases Improve Interrogation of Lung Transcriptomic DataFlint J, Sharma P, Cosme Jr. C, Neumark N, Adams T, Kim H, Lepe A, Abu Hussein N, Schupp J, Mcdonough J, Sauler M, Yan X, Kaminski N. Online Cell Atlases Improve Interrogation of Lung Transcriptomic Data. 2023, a2223-a2223. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2223.
The Pulmonary Fibrosis Drug ConnectomeFlint J, Sharma P, Adams T, Lepe A, Kim H, Abu Hussein N, Schupp J, Cosme Jr. C, Mcdonough J, Sauler M, Yan X, Kaminski N. The Pulmonary Fibrosis Drug Connectome. 2023, a2234-a2234. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2234.
Single Nuclear RNAseq of Differentially Affected IPF Lung Uncovers Potential Cellular Origins of Aberrant Basaloid CellsAdams T, Schupp J, Balayev A, Justet A, Sharma P, DeIuliis G, Yan X, Wuyts W, Vanaudenaerde B, Kaminski N. Single Nuclear RNAseq of Differentially Affected IPF Lung Uncovers Potential Cellular Origins of Aberrant Basaloid Cells. 2023, a2802-a2802. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2802.
G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal CellsKhoury J, Ahangari F, Barnthaler T, McDonough J, Justet A, Adams T, Schupp J, Alysandratos K, Beermann M, Kotton D, Gomez J, Kaminski N. G-coupled Protein 87 (GPR87) a Cell Surface Orphan Receptor Expressed in Aberrant Basaloid Cells in IPF Mediates LPA Induced Fibrotic Gene Expression in Human iPSC Derived Basal Cells. 2023, a6762-a6762. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6762.
Morphomolecular Pathobiology of the Capillary Network in Alveolar Capillary DysplasiaKamp J, Neubert L, Schupp J, Wrede C, Laenger F, Salditt T, Reichmann J, Welte T, Haverich A, Schwerk N, Bergmann A, von Hardenberg S, Olsson K, Fuge J, Park D, Hoeper M, Kreipe H, Jonigk D, Knudsen L, Kuehnel M. Morphomolecular Pathobiology of the Capillary Network in Alveolar Capillary Dysplasia. 2023, a3650-a3650. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a3650.
Identifikation von aberranten basaloiden Basalzellphänotypen in einem Organoid basierten ex vivo Modell der IPFRuwisch J, Carleo A, Jäger B, Schupp J, Plappert L, Prasse A. Identifikation von aberranten basaloiden Basalzellphänotypen in einem Organoid basierten ex vivo Modell der IPF. Pneumologie 2023, 77: s111-s112. DOI: 10.1055/s-0043-1761143.
microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosisAhangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1463-1479. PMID: 35998281, PMCID: PMC9757097, DOI: 10.1164/rccm.202010-3832oc.
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosisÖz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosisJaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis. Nature Communications 2022, 13: 5637. PMID: 36163190, PMCID: PMC9513076, DOI: 10.1038/s41467-022-33193-0.
CINS: Cell Interaction Network inference from Single cell expression dataYuan Y, Cosme C, Adams TS, Schupp J, Sakamoto K, Xylourgidis N, Ruffalo M, Li J, Kaminski N, Bar-Joseph Z. CINS: Cell Interaction Network inference from Single cell expression data. PLOS Computational Biology 2022, 18: e1010468. PMID: 36095011, PMCID: PMC9499239, DOI: 10.1371/journal.pcbi.1010468.
A Morphomolecular Approach to Alveolar Capillary DysplasiaKamp J, Neubert L, Ackermann M, Stark H, Plucinski E, Shah H, Janciauskiene S, Bergmann A, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson K, Fuge J, Park D, Schupp J, Hoeper M, Kuehnel M, Jonigk D. A Morphomolecular Approach to Alveolar Capillary Dysplasia. American Journal Of Pathology 2022, 192: 1110-1121. PMID: 35649494, DOI: 10.1016/j.ajpath.2022.05.004.
Genotype-Phenotype-Relationship in SarcoidosisMüller-Quernheim J, Schupp J, Freitag-Wolf S, Frye B, Zissel G, Grohé C, Mihailović-Vučinić V, Milanowski J, Rottoli P, Stefan S, Dempfle A. Genotype-Phenotype-Relationship in Sarcoidosis. Pneumologie 2022, 76: s37-s37. DOI: 10.1055/s-0042-1747772.
Sexually Dimorphic Innate Immune Programs of Airway Monocytes in Cystic FibrosisYin H, Li N, Shiner N, Khanal S, Schupp J, Chupp G, Gomez J, Britto-Leon C. Sexually Dimorphic Innate Immune Programs of Airway Monocytes in Cystic Fibrosis. 2022, a1984-a1984. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1984.
Genotype-Phenotype-Relationships in SarcoidosisMuller-Quernheim J, Schupp J, Freitag-Wolf S, Frye B, Zissel G, Grohé C, Mihailovic-Vucinic V, Milanowski J, Rottoli P, Schreiber S, Dempfle A, GenPhenReSa-Consortium. Genotype-Phenotype-Relationships in Sarcoidosis. 2022, a4880-a4880. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4880.
Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease ProgressionSchupp J, Clair G, Adams T, Mcdonough J, Flint J, Kothapalli N, De Sadeleer L, Justet A, Melchior J, Paurus V, Olson H, Deluliis G, Ahangari F, Bar-Joseph Z, Yan X, Ding J, Wuyts W, Vanaudenaerde B, Kaminski N. Single Nuclei RNA Sequencing of Differentially Affected Regions in IPF Lungs Suggests a Central Role of Aberrant Basaloid Cells in Disease Progression. 2022, a4975-a4975. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4975.
Interactive Web-Based Lung Cell Atlases Lower Barriers to Transcriptomic Data Sharing, Mining and DisseminationCosme Jr. C, Flint J, Neumark N, Kothapalli N, Balayev A, Adams T, Schupp J, Mcdonough J, Yan X, Sauler M, Kaminski N. Interactive Web-Based Lung Cell Atlases Lower Barriers to Transcriptomic Data Sharing, Mining and Dissemination. 2022, a4978-a4978. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4978.
A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis ProgressionDing J, Zheng Y, Schupp J, Adams T, Ahangari F, Yan X, Hasen P, Bar-Joseph Z, De Sadeleer L, Mcdonough J, Vanaudenaerde B, Wuyts W, Kaminski N. A Probabilistic Graphical Model for Understanding Cellular Dynamics in Idiopathic Pulmonary Fibrosis Progression. 2022, a4986-a4986. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4986.
Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Singh I, Tellides G, Gill T, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary Artery. 2022, a5205-a5205. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5205.
Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged LungMcdonough J, Cosme Jr. C, Rupert C, Schupp J, Ahangari F, DeIuliis G, Yan X, Hagood J, Vanaudenaerde B, Niklason L, Hansen K, Kaminski N. Decellularized Lung Tissue Proteomics Showed Decreased Surfactant and Increased Inflammatory Proteins in the Aged Lung. 2022, a3903-a3903. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3903.
Aberrant Mesenchymal Signaling in the COPD LungBrewster R, Neeharika N, Mcdonough J, Adams T, Schupp J, Niklason L, Raredon M, Kaminski N, Rosas I, Sauler M. Aberrant Mesenchymal Signaling in the COPD Lung. 2022, a4655-a4655. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4655.
Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic LungJustet A, Adams T, Balayev A, Bärnthaler T, Cosme Jr C, Mcdonough J, Flint J, Schupp J, Zhao A, Deluliis J, Ahangari F, Yan X, Kaminski N. Deconvolution of Spatial Transcriptomic Allows to Predict the Spatial Location of Each Cell Type of Interest in the Fibrotic Lung. 2022, a4991-a4991. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4991.
GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF LungKhoury J, Ahangari F, Barnthaler T, McDonough J, Kothapalli N, Adams T, Schupp J, DeIuliis G, Gomez J, Kaminski N. GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF Lung. 2022, a2325-a2325. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2325.
Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and FerroptosisNouws J, Mcdonough J, Adams T, Werder R, Schupp J, Robertson M, Coarfa C, Poli De Frias S, Wilson A, Timshel P, Kaminski N, Rosas I, Sauler M. Reduced Alveolar Type 2 Epithelial Expression of NUPR1 Is Associated with Severe COPD and Increases Susceptibility to Oxidative Stress and Ferroptosis. 2022, a1040-a1040. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1040.
New Insights on Idiopathic Pulmonary Fibrosis Revealed by Proteomics and Lipidomics Analysis of Human Tissue CoresClair G, Kyle J, Melchior J, Olson H, Paurus V, Bloodsworth K, Schupp J, Mcdonough J, Wuyts W, Vanaudenaerde B, Kaminski N. New Insights on Idiopathic Pulmonary Fibrosis Revealed by Proteomics and Lipidomics Analysis of Human Tissue Cores. 2022, a1972-a1972. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1972.
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary FibrosisPreisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells 2022, 11: 1341. PMID: 35456020, PMCID: PMC9027113, DOI: 10.3390/cells11081341.
Feasibility of Prolonged Calcineurin-Inhibitor Free Immunosuppression After Lung Transplantation - A Retrospective Single Center AnalysisGottlieb J, Valtin C, Fischer B, Schupp J, Golpon H. Feasibility of Prolonged Calcineurin-Inhibitor Free Immunosuppression After Lung Transplantation - A Retrospective Single Center Analysis. The Journal Of Heart And Lung Transplantation 2022, 41: s421. DOI: 10.1016/j.healun.2022.01.1061.
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cellsSumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nature Immunology 2022, 23: 632-642. PMID: 35301508, PMCID: PMC8989655, DOI: 10.1038/s41590-022-01152-y.
Computation and visualization of cell–cell signaling topologies in single-cell systems data using ConnectomeRaredon MSB, Yang J, Garritano J, Wang M, Kushnir D, Schupp JC, Adams TS, Greaney AM, Leiby KL, Kaminski N, Kluger Y, Levchenko A, Niklason LE. Computation and visualization of cell–cell signaling topologies in single-cell systems data using Connectome. Scientific Reports 2022, 12: 4187. PMID: 35264704, PMCID: PMC8906120, DOI: 10.1038/s41598-022-07959-x.
Characterization of the COPD alveolar niche using single-cell RNA sequencingSauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason L, Ko A, Montgomery R, Farhadian S, Iwasaki A, Shaw A, van Dijk D, Zhao H, Kleinstein S, Hafler D, Kaminski N, Dela Cruz C. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications 2022, 13: 440. PMID: 35064122, PMCID: PMC8782894, DOI: 10.1038/s41467-021-27716-4.
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic ImpactDe Sadeleer LJ, Verleden SE, Schupp JC, McDonough JE, Goos T, Yserbyt J, Bargagli E, Rottoli P, Kaminski N, Prasse A, Wuyts WA. BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact. CHEST Journal 2022, 161: 1576-1588. PMID: 35063449, PMCID: PMC9424328, DOI: 10.1016/j.chest.2021.12.668.
Kapitel 12 SarkoidoseFrye B, Schupp J, Müller-Quernheim J. Kapitel 12 Sarkoidose. 2022, 103-116. DOI: 10.1016/b978-3-437-23814-7.00012-7.
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.De Sadeleer LJ, McDonough JE, Schupp JC, Yan X, Vanstapel A, Van Herck A, Everaerts S, Geudens V, Sacreas A, Goos T, Aelbrecht C, Nawrot TS, Martens DS, Schols D, Claes S, Verschakelen JA, Verbeken EK, Ackermann M, Decottignies A, Mahieu M, Hackett TL, Hogg JC, Vanaudenaerde BM, Verleden SE, Kaminski N, Wuyts WA. Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis. American Journal Of Respiratory And Critical Care Medicine 2022, 205: 60-74. PMID: 34724391, PMCID: PMC8865586, DOI: 10.1164/rccm.202103-0569oc.
FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patientsFrye B, Potasso L, Farin-Glattacker E, Birring S, Müller-Quernheim J, Schupp J. FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients. BMC Pulmonary Medicine 2021, 21: 395. PMID: 34861850, PMCID: PMC8643005, DOI: 10.1186/s12890-021-01761-7.
A Pulmonary Vascular Model From Endothelialized Whole Organ ScaffoldsYuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers In Bioengineering And Biotechnology 2021, 9: 760309. PMID: 34869270, PMCID: PMC8640093, DOI: 10.3389/fbioe.2021.760309.
S98 Dissecting human pleura at single-cell resolutionObacz J, Adams T, Schupp J, Kaminski N, Aresu G, Coonar A, Peryt A, Rassl D, Rintoul R, Marciniak S. S98 Dissecting human pleura at single-cell resolution. 2021, a63.1-a63. DOI: 10.1136/thorax-2021-btsabstracts.104.
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic DataManning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patientsFrye B, Potasso L, Farin E, Fichtner U, Birring S, Müller-Quernheim J, Schupp J. Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients. Respiratory Medicine 2021, 188: 106600. PMID: 34530353, DOI: 10.1016/j.rmed.2021.106600.
FeV1 and body weight weight on LCQ in sarcoidosis patientsFrye B, Soriano D, Farin E, Müller-Quernheim J, Schupp J. FeV1 and body weight weight on LCQ in sarcoidosis patients. 2021, oa3983. DOI: 10.1183/13993003.congress-2021.oa3983.
Aberrant endothelial CXCL signaling in COPDKothapalli N, Mcdonough J, Raredon M, Adams T, Schupp J, Niklason L, Kaminski N, Rosas I, Sauler M. Aberrant endothelial CXCL signaling in COPD. 2021, pa3623. DOI: 10.1183/13993003.congress-2021.pa3623.
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severityBui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE. Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity. Nature Communications 2021, 12: 4314. PMID: 34262047, PMCID: PMC8280215, DOI: 10.1038/s41467-021-24467-0.
Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Research Square 2021 PMID: 34127967, PMCID: PMC8202434, DOI: 10.21203/rs.3.rs-133494/v1.
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosisVukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. European Respiratory Journal 2021, 58: 2002950. PMID: 34083402, PMCID: PMC9759791, DOI: 10.1183/13993003.02950-2020.
Integrated Single-Cell Atlas of Endothelial Cells of the Human LungSchupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.
Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression ProfilesZhao A, Unterman A, Schupp J, Adams T, Sumida T, Ryu C, DeIuliis G, Yan X, Hafler D, Dela Cruz C, Herzog E, Kaminski N. Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles. 2021, a4361-a4361. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4361.
Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived CellsCosme Jr. C, Adams T, Schupp J, Mcdonough J, Ahangari F, DeIuliis G, Omote N, Dixit V, Kaminski N. Single-Cell RNAseq of Aging Lungs from Nlrp3 -/- Mice Reveals Genotype- and Cell Type-Specific Effects of Aging on the Transcriptomes of Several Myeloid-Derived Cells. 2021, a4402-a4402. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4402.
Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from HypoxiaManning E, Ramachandra A, Schupp J, Cavinato C, Singh I, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from Hypoxia. 2021, a3625-a3625. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3625.
Targeting the IPF-Expanded Macrophages: Identification and Drug Discovery via scRNAseq and CyTOFPoli De Frias S, Ayaub E, Adams T, Schupp J, Ng J, Quesada L, Martinez J, Planchart M, Robertson M, Chu S, Coarfa C, El-Chemaly S, Perrella M, Washko G, Raby B, Kaminski N, Rosas I. Targeting the IPF-Expanded Macrophages: Identification and Drug Discovery via scRNAseq and CyTOF. 2021, a4435-a4435. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4435.
Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPDMcDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme Jr. C, Poli De Frias S, Ayaub E, Chu S, Jensen K, Gomez J, Britto-Leon C, Raredon M, Niklason L, Timshel P, Kaminski N, Rosas I, Sauler M. Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD. 2021, a4281-a4281. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4281.
Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell StateSchupp J, Adams T, Ahangari F, McDonough J, DeIuliis G, Poli S, Rosas I, Yan X, Kaminski N. Single Cell RNA Velocity Analysis of Aberrant Basaloid Cells in Pulmonary Fibrosis Reveals Trajectory Towards an Alveolar Type I Like Cell State. 2021, a4350-a4350. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4350.
Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of LymphocytesAdams T, Schupp J, Mcdonough J, Chioccioli M, Rose K, DeIuliis G, Yan X, Kaminski N. Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of Lymphocytes. 2021, a4351-a4351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4351.
Macrophage Specific Regulatory Role of miR-33 in Pulmonary FibrosisAhangari F, Chioccioli M, Malik S, Baernthaler T, Price N, Ding S, Rose K, Mcdonough J, Omote N, Schupp J, Adams T, Sharma L, DeIuliis G, Dela Cruz C, Prasse A, Bahal R, Fernandez-Hernando C, Kaminski N. Macrophage Specific Regulatory Role of miR-33 in Pulmonary Fibrosis. 2021, a4452-a4452. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4452.
Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthmaChen A, Diaz-Soto MP, Sanmamed MF, Adams T, Schupp JC, Gupta A, Britto C, Sauler M, Yan X, Liu Q, Nino G, Cruz CSD, Chupp GL, Gomez JL. Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma. Respiratory Research 2021, 22: 122. PMID: 33902571, PMCID: PMC8074196, DOI: 10.1186/s12931-021-01709-9.
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographicsMuus C, Luecken M, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav E, Subramanian A, Smillie C, Jagadeesh K, Duong E, Fiskin E, Torlai Triglia E, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber A, Chung H, Montoro D, Adams T, Aliee H, Allon S, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui L, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon T, Cuoco M, Cuomo A, Deprez M, Duclos G, Fine D, Fischer D, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez A, Habermann A, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos T, Kuo C, Larsson L, Leney-Greene M, Lim K, Litviňuková M, Ludwig L, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr C, Mbano I, McAdams A, Nabhan A, Nyquist S, Penland L, Poirion O, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp J, Shea C, Shi X, Sinha R, Sit R, Slowikowski K, Slyper M, Smith N, Sountoulidis A, Strunz M, Sullivan T, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini K, Tucker N, Vernon K, Wadsworth M, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler C. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature Medicine 2021, 27: 546-559. PMID: 33654293, PMCID: PMC9469728, DOI: 10.1038/s41591-020-01227-z.
Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung DiseaseFriedmann D, Unger S, Keller B, Rakhmanov M, Goldacker S, Zissel G, Frye B, Schupp J, Prasse A, Warnatz K. Bronchoalveolar Lavage Fluid Reflects a TH1-CD21low B-Cell Interaction in CVID-Related Interstitial Lung Disease. Frontiers In Immunology 2021, 11: 616832. PMID: 33613543, PMCID: PMC7892466, DOI: 10.3389/fimmu.2020.616832.
Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation stateOmote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.
S2K Guideline for Diagnosis of Idiopathic Pulmonary FibrosisBehr J, Günther A, Bonella F, Dinkel J, Fink L, Geiser T, Geissler K, Gläser S, Handzhiev S, Jonigk D, Koschel D, Kreuter M, Leuschner G, Markart P, Prasse A, Schönfeld N, Schupp J, Sitter H, Müller-Quernheim J, Costabel U. S2K Guideline for Diagnosis of Idiopathic Pulmonary Fibrosis. Respiration 2021, 100: 238-271. PMID: 33486500, DOI: 10.1159/000512315.
Toward a Cell Atlas of the Human AirwaySchupp JC, Yan X, Kaminski N. Toward a Cell Atlas of the Human Airway. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1611-1612. PMID: 32841575, PMCID: PMC7737583, DOI: 10.1164/rccm.202007-2977ed.
Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiencyChu JH, Zang W, Vukmirovic M, Yan X, Adams T, DeIuliis G, Hu B, Mihaljinec A, Schupp JC, Becich MJ, Hochheiser H, Gibson KF, Chen ES, Morris A, Leader JK, Wisniewski SR, Zhang Y, Sciurba FC, Collman RG, Sandhaus R, Herzog EL, Patterson KC, Sauler M, Strange C, Kaminski N. Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency. Thorax 2020, 76: 134-143. PMID: 33303696, PMCID: PMC10794043, DOI: 10.1136/thoraxjnl-2019-214301.
Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndromeMorrone C, Smirnova NF, Jeridi A, Kneidinger N, Hollauer C, Schupp JC, Kaminski N, Jenne D, Eickelberg O, Yildirim AÖ. Cathepsin B promotes collagen biosynthesis, which drives bronchiolitis obliterans syndrome. European Respiratory Journal 2020, 57: 2001416. PMID: 33303550, DOI: 10.1183/13993003.01416-2020.
Abstract 14125: An in vitro Pulmonary Vascular Platform From Endothelialized Whole Lung ScaffoldsYuan Y, Leiby K, Greaney A, Raredon M, Qian H, Baevova P, Admas T, Engler A, Kural M, Schupp J, Hong Y, Kaminski N, Niklason L. Abstract 14125: An in vitro Pulmonary Vascular Platform From Endothelialized Whole Lung Scaffolds. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.14125.
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2020, 202: 1419-1429. PMID: 32603604, PMCID: PMC7667912, DOI: 10.1164/rccm.202004-0991oc.
Correlation of King’s Sarcoidosis Questionnaire with clinical parametersFrye B, Farin-Glattacker E, Müller-Quernheim J, Schupp J. Correlation of King’s Sarcoidosis Questionnaire with clinical parameters. 2020, 3016. DOI: 10.1183/13993003.congress-2020.3016.
S2K-Leitlinie zur Diagnostik der idiopathischen LungenfibroseBehr J, Günther A, Bonella F, Dinkel J, Fink L, Geiser T, Geißler K, Gläser S, Handzhhiev S, Jonigk D, Koschel D, Kreuter M, Leuschner G, Markart P, Prasse A, Schönfeld N, Schupp J, Sitter H, Müller-Quernheim J, Costabel U. S2K-Leitlinie zur Diagnostik der idiopathischen Lungenfibrose. Pneumologie 2020, 74: e1-e2. PMID: 32422671, DOI: 10.1055/a-1179-2905.
Background Contamination Correction in Human Lung Single-Cell RNA Sequencing DataZang W, Schupp J, Kane M, Adams T, Poli De Frias S, Rosas I, Kaminski N, Chu J. Background Contamination Correction in Human Lung Single-Cell RNA Sequencing Data. 2020, a4024-a4024. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4024.
IFN-αβ Are Enhancers of Granulomatous InflammationEngelhard P, Maler M, Schupp J, Muller-Quernheim J, Prasse A, Freudenberg M. IFN-αβ Are Enhancers of Granulomatous Inflammation. 2020, a4036-a4036. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4036.
Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung CancerSchupp J, Adams T, Ahangari F, Poli De Frias S, DeIuliis G, Yan X, Rosas I, Homer R, Kaminski N. Single Cell Transcriptomics Reveals Novel COL15A1+ Endothelial Population in Pulmonary Fibrosis and Lung Cancer. 2020, a6142-a6142. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6142.
Gene Expression Patterns Distinctly Characterize Differentially Affected Regions in Human Fibrotic Hypersensitivity Pneumonitis LungsDe Sadeleer L, McDonough J, Schupp J, Yan X, Vanaudenaerde B, Verleden S, Kaminski N, Wuyts W. Gene Expression Patterns Distinctly Characterize Differentially Affected Regions in Human Fibrotic Hypersensitivity Pneumonitis Lungs. 2020, a2262-a2262. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2262.
Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPFAdams T, Schupp J, McDonough J, Ahangari F, DeIuliis G, Yan X, Rosas I, Kaminski N. Deconvolution of Bulk RNAseq Datasets Confirms Substantial Cellular Population Shifts in the Distal Lung in IPF. 2020, a2248-a2248. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2248.
Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Hashimoto N, Hasegawa Y, Kaminski N. Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell Differentiation. 2020, a5987-a5987. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5987.
Low Surfactant Type II Alveolar Epithelial Cells Are an Enriched Cell Population in the Aged LungMcDonough J, Adams T, Schupp J, DeIuliis G, Yan X, Cosme jr C, Kaminski N. Low Surfactant Type II Alveolar Epithelial Cells Are an Enriched Cell Population in the Aged Lung. 2020, a4390-a4390. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4390.
Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory AberrationsCosme Jr. C, McDonough J, Adams T, Schupp J, Omote N, Ahangari F, DeIuliis G, Sakamoto K, Kaminski N. Single-Cell RNAseq of Aging Mouse Lungs Reveals Global and Cell-Specific Inflammatory Aberrations. 2020, a4389-a4389. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4389.
Characterization of Sputum Single Cell Transcriptomes in AsthmaYan X, Liu Q, Adams T, Schupp J, Grant N, Gomez J, Cohn L, Chupp G. Characterization of Sputum Single Cell Transcriptomes in Asthma. 2020, a3046-a3046. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3046.
Single Cell RNA Sequencing Reveals Altered T-Cell Repertoire and Gene Expression in the Peripheral Blood and Lungs of Patients with Idiopathic Pulmonary FibrosisUnterman A, Neumark N, Zhao A, Schupp J, Adams T, Antin-Ozerkis D, Winkler J, Banovich N, Kropski J, Herzog E, Kaminski N. Single Cell RNA Sequencing Reveals Altered T-Cell Repertoire and Gene Expression in the Peripheral Blood and Lungs of Patients with Idiopathic Pulmonary Fibrosis. 2020, a2516-a2516. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2516.
Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene SignatureUnterman A, Neumark N, Zhao A, Schupp J, Ryu C, Antin-Ozerkis D, Winkler J, Herazo-Maya J, Herzog E, Kaminski N. Single Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis Reveals the Cellular Origin of the Outcome Predictive 52-Gene Signature. 2020, a6211-a6211. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6211.
Saracatinib Is a Potential Novel Therapeutic for Pulmonary FibrosisAhangari F, Becker C, Foster D, Chioccioli M, Nelson M, Beke K, Meador C, Wang X, Corell K, Roybal H, DeIuliis G, Rose K, Schupp J, Li Q, Adams T, Aschner Y, Lilli L, Readhead B, Cousens L, Dudley J, Kaminski N, Downey G. Saracatinib Is a Potential Novel Therapeutic for Pulmonary Fibrosis. 2020, a2784-a2784. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2784.
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosisTsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nature Communications 2020, 11: 1920. PMID: 32317643, PMCID: PMC7174390, DOI: 10.1038/s41467-020-15647-5.
S2K-Leitlinie zur Diagnostik der idiopathischen LungenfibroseBehr J, Günther A, Bonella F, Dinkel J, Fink L, Geiser T, Geißler K, Gläser S, Handzhhiev S, Jonigk D, Koschel D, Kreuter M, Leuschner G, Markart P, Prasse A, Schönfeld N, Schupp J, Sitter H, Müller-Quernheim J, Costabel U. S2K-Leitlinie zur Diagnostik der idiopathischen Lungenfibrose. Pneumologie 2020, 74: 263-293. PMID: 32227328, DOI: 10.1055/a-1120-3531.
Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA SequencingGreaney AM, Adams TS, Raredon M, Gubbins E, Schupp JC, Engler AJ, Ghaedi M, Yuan Y, Kaminski N, Niklason LE. Platform Effects on Regeneration by Pulmonary Basal Cells as Evaluated by Single-Cell RNA Sequencing. Cell Reports 2020, 30: 4250-4265.e6. PMID: 32209482, PMCID: PMC7175071, DOI: 10.1016/j.celrep.2020.03.004.
E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute LungenschädigungSchupp JC, Prasse A, Erythropel HC. E-Zigaretten – Funktionsweise, Inhaltsstoffe und die Vaping-assoziierte akute Lungenschädigung. Pneumologie 2020, 74: 77-87. PMID: 32016924, PMCID: PMC7366312, DOI: 10.1055/a-1078-8126.
Single-cell connectomic analysis of adult mammalian lungsRaredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Science Advances 2019, 5: eaaw3851. PMID: 31840053, PMCID: PMC6892628, DOI: 10.1126/sciadv.aaw3851.
Toward Early Detection of Idiopathic Pulmonary FibrosisSchupp JC, Kaminski N. Toward Early Detection of Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2019, 200: 1339-1340. PMID: 31412723, PMCID: PMC6884034, DOI: 10.1164/rccm.201908-1530ed.
The value of bronchoalveolar lavage for discrimination between healthy and diseased individualsFrye B, Schupp J, Rothe M, Köhler T, Prasse A, Zissel G, Vach W, Müller‐Quernheim J. The value of bronchoalveolar lavage for discrimination between healthy and diseased individuals. Journal Of Internal Medicine 2019, 287: 54-65. PMID: 31612575, DOI: 10.1111/joim.12973.
Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in SarcoidosisSchupp J, Adams T, Jäger B, Deluiis G, Ahangari F, Kaminski N, Prasse A. Single Cell RNA Sequencing profiles Distinct BAL Cell Subpopulations in Sarcoidosis. 2019, oa5154. DOI: 10.1183/13993003.congress-2019.oa5154.
Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene ExpressionPoli De Frias S, Adams T, Schupp J, Chu S, Neumark N, Ahangari F, Waskho G, Raby B, Kaminski N, Rosas I. Single Cell RNA Sequencing of Human Lung Explants Identifies the Cell-Specific Contributions of Extracellular Matrix-Related Gene Expression. 2019, a2550-a2550. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2550.
Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell PopulationSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, Omote N, Chioccioli M, Xylourgidis N, DeIuliis G, Chu S, Yan X, Rosas I, Kaminski N. Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population. 2019, a4017-a4017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4017.
Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF LungAdams T, Schupp J, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Raredon M, Yan X, Rosas I, Kaminski N. Archetype Analysis Reveals Distinct Disease-Specific Archetypes of Fibroblast and Myofibroblast Co-Occurring Within the IPF Lung. 2019, a4018-a4018. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4018.
Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF PatientsSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, DeIuliis G, Chu S, Yan X, Kaminski N, Prasse A, Rosas I. Macrophage Programs in BAL and Lung Parenchyma of the Healthy and in IPF Patients. 2019, a5247-a5247. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5247.
Bronchoalveolar Cell Transcriptome of Acute Exacerbation in Idiopathic Pulmonary FibrosisPrasse A, Jäger B, Schupp J, Kaminski N, Carleo A. Bronchoalveolar Cell Transcriptome of Acute Exacerbation in Idiopathic Pulmonary Fibrosis. 2019, a5259-a5259. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5259.
Loss of lncRNA FENDRR Induces Senescence in Adult Mouse LungsXylourgidis N, Sakamoto K, Schupp J, Adams T, DeIuliis G, Omote N, Hashimoto N, Hasegawa Y, Kaminski N. Loss of lncRNA FENDRR Induces Senescence in Adult Mouse Lungs. 2019, a5274-a5274. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5274.
TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Xylourgidis N, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation. 2019, a5406-a5406. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5406.
Basal Epithelial Progenitor Cells for Pulmonary Engineering as Evaluated by Single-Cell TranscriptomicsGreaney A, Raredon M, Adams T, Schupp J, Kaminski N, Niklason L. Basal Epithelial Progenitor Cells for Pulmonary Engineering as Evaluated by Single-Cell Transcriptomics. 2019, a5890-a5890. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5890.
Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in LungRaredon M, Adams T, Schupp J, Suhail Y, Leiby K, Greaney A, Boffa D, Levchenko A, Kaminski N, Niklason L. Cross-Species scRNAseq Systems Biology Analysis of Cell-Cell Signaling in Lung. 2019, a6073-a6073. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6073.
A Novel Interface for Sharing the Human Cell IPF AtlasNeumark N, Adams T, Schupp J, Yan X, Poli De Frias S, Kaminski N. A Novel Interface for Sharing the Human Cell IPF Atlas. 2019, a6076-a6076. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6076.
Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic ImplicationsAhangari F, Price N, Schupp J, Rose K, Ibarra G, DeIuliis G, Xylourgidis N, Prasse A, Fernandez-Hernando C, Kaminski N. Profibrotic Effects of Mir-33 - Role of Autophagy and Mitochondrial Homeostasis in Macrophages, and Therapeutic Implications. 2019, a7222-a7222. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7222.
Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German languageFarin E, Heyduck K, Frye BC, Birring SS, Müller-Quernheim J, Schupp JC. Translation and psychometric properties of the King’s Sarcoidosis Questionnaire (KSQ) in German language. Health And Quality Of Life Outcomes 2019, 17: 62. PMID: 30975148, PMCID: PMC6460543, DOI: 10.1186/s12955-019-1131-z.
BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary FibrosisPrasse A, Binder H, Schupp JC, Kayser G, Bargagli E, Jaeger B, Hess M, Rittinghausen S, Vuga L, Lynn H, Violette S, Jung B, Quast K, Vanaudenaerde B, Xu Y, Hohlfeld JM, Krug N, Herazo-Maya JD, Rottoli P, Wuyts WA, Kaminski N. BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 622-630. PMID: 30141961, PMCID: PMC6396865, DOI: 10.1164/rccm.201712-2551oc.
Key Role of HDAC6 Overexpression in the Migration, Proliferation and Fibrotic Remodelling by Airway Basal CellsJäger B, Plappert L, Reusz S, Rittinghausen S, Campiani B, Schupp J, Prasse A. Key Role of HDAC6 Overexpression in the Migration, Proliferation and Fibrotic Remodelling by Airway Basal Cells. Pneumologie 2019, 73: 113-113. DOI: 10.1055/s-0039-1678396.
Kapitel 17 SarkoidoseFrye B, Schupp J, Müller-Quernheim J. Kapitel 17 Sarkoidose. 2019, 145-156. DOI: 10.1016/b978-3-437-24951-8.00017-8.
Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosisSchupp JC, Fichtner UA, Frye BC, Heyduck-Weides K, Birring SS, Windisch W, Criée CP, Müller-Quernheim J, Farin E. Psychometric properties of the German version of the Leicester Cough Questionnaire in sarcoidosis. PLOS ONE 2018, 13: e0205308. PMID: 30286204, PMCID: PMC6171952, DOI: 10.1371/journal.pone.0205308.
Genetic Profiles of Clinical Features in SarcoidosisFreitag-Wolf S, Schupp J, Fischer A, Mihailović-Vučinić V, Rottoli P, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Genetic Profiles of Clinical Features in Sarcoidosis. 2018, oa2160. DOI: 10.1183/13993003.congress-2018.oa2160.
BAL cell transcriptome predicts survival in IPF and can be used to gauge and model treatment effects interfering with the TGF-beta pathwayPrasse A, Carleo A, Jaeger B, Schupp J, Rottoli P, Wuyts W, Kaminski N. BAL cell transcriptome predicts survival in IPF and can be used to gauge and model treatment effects interfering with the TGF-beta pathway. 2018, oa5359. DOI: 10.1183/13993003.congress-2018.oa5359.
Bronchoalveolar lavage in healthy and diseased individualsFrye B, Schupp J, Köhler T, Zissel G, Vach W, Müller-Quernheim J. Bronchoalveolar lavage in healthy and diseased individuals. 2018, pa2965. DOI: 10.1183/13993003.congress-2018.pa2965.
Phenotypes of organ involvement in sarcoidosisSchupp J, Freitag-Wolf S, Bargagli E, Mihailović-Vučinić V, Rottoli P, Grubanovic A, Müller A, Jochens A, Tittmann L, Schnerch J, Olivieri C, Fischer A, Jovanovic D, Filipovic S, Videnovic-Ivanovic J, Bresser P, Jonkers R, O'Reilly K, Ho L, Gaede K, Zabel P, Dubaniewicz A, Marshall B, Kieszko R, Milanowski J, Günther A, Weihrich A, Petrek M, Kolek V, Keane M, O'Beirne S, Donnelly S, Haraldsdottir S, Jorundsdottir K, Costabel U, Bonella F, Wallaert B, Grah C, Peroš-Golubičić T, Luisetti M, Kadija Z, Pabst S, Grohé C, Strausz J, Vašáková M, Sterclova M, Millar A, Homolka J, Slováková A, Kendrick Y, Crawshaw A, Wuyts W, Spencer L, Pfeifer M, Valeyre D, Poletti V, Wirtz H, Prasse A, Schreiber S, Krawczak M, Müller-Quernheim J. Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 2018, 51: 1700991. PMID: 29371378, DOI: 10.1183/13993003.00991-2017.
Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune DysregulationFriedmann D, Keller B, Harder I, Schupp J, Tanriver Y, Unger S, Warnatz K. Preferential Reduction of Circulating Innate Lymphoid Cells Type 2 in Patients with Common Variable Immunodeficiency with Secondary Complications Is Part of a Broader Immune Dysregulation. Journal Of Clinical Immunology 2017, 37: 759-769. PMID: 28936778, DOI: 10.1007/s10875-017-0444-0.
Transcriptome profiles in sarcoidosis and their potential role in disease predictionSchupp JC, Vukmirovic M, Kaminski N, Prasse A. Transcriptome profiles in sarcoidosis and their potential role in disease prediction. Current Opinion In Pulmonary Medicine 2017, 23: 487-492. PMID: 28590292, PMCID: PMC5637542, DOI: 10.1097/mcp.0000000000000403.
Sarcoidosis: Drugs under InvestigationSchupp J, Frye B, Zissel G, Müller-Quernheim J. Sarcoidosis: Drugs under Investigation. Seminars In Respiratory And Critical Care Medicine 2017, 38: 532-537. PMID: 28750466, DOI: 10.1055/s-0037-1603768.
SarkoidoseSchupp J, Prasse A. Sarkoidose. Pneumo News 2017, 9: 37-44. DOI: 10.1007/s15033-017-0560-9.
SarkoidoseFrye B, Schupp J, Köhler T, Voll R, Müller-Quernheim J. Sarkoidose. Zeitschrift Für Rheumatologie 2016, 75: 389-401. PMID: 27146405, DOI: 10.1007/s00393-016-0086-2.
Editorial: cardiac volume overload and pulmonary hypertension in long‐term follow‐up of TIPSS patientsRössle M, Schupp J, Köhler T, Schultheiss M. Editorial: cardiac volume overload and pulmonary hypertension in long‐term follow‐up of TIPSS patients. Alimentary Pharmacology & Therapeutics 2016, 43: 1233-1235. PMID: 27137723, DOI: 10.1111/apt.13599.
Usefulness of Cyclophosphamide Pulse Therapy in Interstitial Lung DiseasesSchupp J, Köhler T, Müller-Quernheim J. Usefulness of Cyclophosphamide Pulse Therapy in Interstitial Lung Diseases. Respiration 2016, 91: 296-301. PMID: 27082957, DOI: 10.1159/000445031.
Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der SarkoidoseSchupp J, Frye B, Zissel G, Müller-Quernheim J. Neue pathogenetische Konzepte und frühe pharmakologische Studien bei der Sarkoidose. Pneumologie 2016, 70: 231-240. PMID: 26937647, DOI: 10.1055/s-0041-108311.
Erratum zu: Diagnostik und Therapie der Sarkoidose. Was ist gesichert?Frye B, Schupp J, Köhler T, Müller-Quernheim J. Erratum zu: Diagnostik und Therapie der Sarkoidose. Was ist gesichert? Der Internist 2015, 57: 37-37. PMID: 26678285, DOI: 10.1007/s00108-015-3855-0.
Diagnostik und Therapie der SarkoidoseFrye B, Schupp J, Köhler T, Müller-Quernheim J. Diagnostik und Therapie der Sarkoidose. Der Internist 2015, 56: 1346-1352. PMID: 26563335, DOI: 10.1007/s00108-015-3757-1.
Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitroSchupp J, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg M, Prasse A. Immune response to Propionibacterium acnes in patients with sarcoidosis – in vivo and in vitro. BMC Pulmonary Medicine 2015, 15: 75. PMID: 26204953, PMCID: PMC4513400, DOI: 10.1186/s12890-015-0070-7.
Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary FibrosisSchupp J, Binder H, Jäger B, Cillis G, Zissel G, Müller-Quernheim J, Prasse A. Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. PLOS ONE 2015, 10: e0116775. PMID: 25590613, PMCID: PMC4295887, DOI: 10.1371/journal.pone.0116775.
Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosisSchupp J, Becker M, Günther J, Müller-Quernheim J, Riemekasten G, Prasse A. Serum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis. European Respiratory Journal 2014, 43: 1530-1532. PMID: 24789955, DOI: 10.1183/09031936.00131713.
BiomarkersSchupp J, Prasse A. Biomarkers. 2013, 90-95. DOI: 10.1183/1025448x.10045012.
Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage ActivationStahl M, Schupp J, Jäger B, Schmid M, Zissel G, Müller-Quernheim J, Prasse A. Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation. PLOS ONE 2013, 8: e81382. PMID: 24278429, PMCID: PMC3835428, DOI: 10.1371/journal.pone.0081382.
Sodium oxybate–induced central sleep apneasFrase L, Schupp J, Sorichter S, Randelshofer W, Riemann D, Nissen C. Sodium oxybate–induced central sleep apneas. Sleep Medicine 2013, 14: 922-924. PMID: 23834969, DOI: 10.1016/j.sleep.2013.03.023.
Gene expression in BAL cells of patients with sarcoidosisSchupp J, Müller-Quernheim J, Prasse A. Gene expression in BAL cells of patients with sarcoidosis. Pneumologie 2013, 67 DOI: 10.1055/s-0033-1334526.
Increase in inflammasome activation in acute exacerbation of idiopathic pulmonary fibrosisJäger B, Schupp J, Hornung V, Müller-Quernheim J, Prasse A. Increase in inflammasome activation in acute exacerbation of idiopathic pulmonary fibrosis. Pneumologie 2012, 66 DOI: 10.1055/s-0032-1329822.
Gene expression in BAL cells of patients with sarcoidosisSchupp J, Müller-Quernheim J, Prasse A. Gene expression in BAL cells of patients with sarcoidosis. Pneumologie 2012, 66 DOI: 10.1055/s-0032-1329838.
CCL18 Predicts Clinical Course And Outcome Of Idiopathic Pulmonary Fibrosis (IPF)Probst C, Schupp J, Kollert F, Jager B, Muller-Quernheim J, Prasse A. CCL18 Predicts Clinical Course And Outcome Of Idiopathic Pulmonary Fibrosis (IPF). 2012, a4383-a4383. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4383.
Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in SarcoidosisPrasse A, Zissel G, Lützen N, Schupp J, Schmiedlin R, Gonzalez-Rey E, Rensing-Ehl A, Bacher G, Cavalli V, Bevec D, Delgado M, Müller-Quernheim J. Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2010, 182: 540-548. PMID: 20442436, DOI: 10.1164/rccm.200909-1451oc.
M2 Marker Expression By Alveolar Macrophages Predicts Survival In IPFSchupp J, Zissel G, Bargagli E, Rottoli P, Müller-Quernheim J, Prasse A. M2 Marker Expression By Alveolar Macrophages Predicts Survival In IPF. 2010, a6024-a6024. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6024.
Propionibakterium-Lysat induzierte inflammatorische Lungenveränderungen in Abhängigkeit vom genetischem HintergrundSchupp J, Tchapchet S, Freudenberg M, Zissel G, Müller-Quernheim J, Prasse A. Propionibakterium-Lysat induzierte inflammatorische Lungenveränderungen in Abhängigkeit vom genetischem Hintergrund. Pneumologie 2009, 63 DOI: 10.1055/s-0029-1202430.

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Jonas Christian Schupp, MD

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