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INFORMATION FOR

Ruth R Montgomery, PhD

Professor of Medicine and Professor of Epidemiology (Microbial Diseases); Director, Yale CyTOF Facility, Present; Associate Dean for Scientific Affairs, Dept Clinical: Internal Medicine

Contact Information

Ruth R Montgomery, PhD

Mailing Addresses

  • Rheumatology

    PO Box 208056, 333 Cedar Street

    New Haven, CT 06520-8056

    United States

  • Rheumatology

    300 Cedar St

    New Haven, CT 06520

    United States

Research Summary

My research focuses on translational studies of primary human cells in disease susceptibility and divergent clinical outcomes. The focus of our lab’s research is on use of novel emerging technology and high-dimensional OMICs platforms to define mechanisms of immune responses. The lab's projects include the effect of aging on immunity, divergent responses to infection with West Nile virus and SARS CoV2, and studies of inflammatory processes in asthma and sickle cell disease. We have published several methods using CyTOF, a mass-spec based cell analyzer which provides multi-dimensional (~50) single cell data in suspension or in tissue sections essentially without background signals or overlap between signals. We have used this expertise in collaborative studies of airway responses in asthma and COVID-19 infections.

Specialized Terms: Innate Immunity; Macrophage; Neutrophil; Aging; West Nile Virus

Extensive Research Description

Immune profiling; Single cell mass cytometry

Coauthors

Research Interests

Aging; Asthma; Immune System; Immunity, Innate; Immune System Diseases; Macrophages; Neutrophils; Pathology; Public Health; Rheumatology; Virus Diseases; West Nile virus; COVID-19

Public Health Interests

Immunology

Research Images

Selected Publications

  • Using ‘big data’ to disentangle aging and COVID-19Montgomery R, Steen H. Using ‘big data’ to disentangle aging and COVID-19 Nature Aging 2021, 1: 496-497. DOI: 10.1038/s43587-021-00078-8.
  • Age-Related Changes in Immune Regulation by Noncoding RNAsWang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs 2019, 1241-1258. DOI: 10.1007/978-3-319-99375-1_109.
  • Analysis of Sputum Immune Cell Populations and Their Functional Status in AsthmaticsStewart E, Chupp G, Montgomery R, Liu Q, Estrom J. Analysis of Sputum Immune Cell Populations and Their Functional Status in Asthmatics 2019, a2916-a2916. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2916.
  • Abstract 5306: SAUCIE: Sparse autoencoder for unsupervised clustering, imputation, and embeddingAmodio M, Srinivasan K, Dijk D, Mohsen H, Yim K, Muhle R, Moon K, Montgomery R, Noonan J, Wolf G, Krishnaswamy S. Abstract 5306: SAUCIE: Sparse autoencoder for unsupervised clustering, imputation, and embedding Cancer Research 2018, 78: 5306-5306. DOI: 10.1158/1538-7445.am2018-5306.
  • Abstract P2-09-18: Multiplexed (18-Plex) measurement of protein targets in trastuzumab-treated patients using imaging mass cytometryCarvajal-Hausdorf D, Stanton K, Patsenker J, Villarroel-Espindola F, Esch A, Montgomery R, Psyrri A, Kalogeras K, Kotoula V, Fountzilas G, Schalper K, Kluger Y, Rimm D. Abstract P2-09-18: Multiplexed (18-Plex) measurement of protein targets in trastuzumab-treated patients using imaging mass cytometry Cancer Research 2018, 78: p2-09-18-p2-09-18. DOI: 10.1158/1538-7445.sabcs17-p2-09-18.
  • Age-Related Changes in Immune Regulation by Noncoding RNAsWang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs 2017, 1-18. DOI: 10.1007/978-3-319-64597-1_109-1.
  • Abstract 1635: Multiplexed analysis of fixed tumor tissues using imaging mass cytometryVillarroel-Espindola F, Carvajal-Hausdorf D, Datar I, Esch A, Rashidi N, Nassar A, Ren S, Montgomery R, Herbst R, Rimm D, Schalper K. Abstract 1635: Multiplexed analysis of fixed tumor tissues using imaging mass cytometry Cancer Research 2017, 77: 1635-1635. DOI: 10.1158/1538-7445.am2017-1635.
  • AGE-RELATED CHANGES IN INNATE IMMUNE CELL FUNCTIONMontgomery R. AGE-RELATED CHANGES IN INNATE IMMUNE CELL FUNCTION Innovation In Aging 2017, 1: 1254-1254. PMCID: PMC6183893, DOI: 10.1093/geroni/igx004.4559.
  • In Memoriam: Stephen E. Malawista, MD, 1934–2013Montgomery R, Bucala R, Bockenstedt L. In Memoriam: Stephen E. Malawista, MD, 1934–2013 Arthritis & Rheumatology 2013, 66: 1-1. DOI: 10.1002/art.38233.
  • Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticksSultana H, Neelakanta G, Kantor F, Malawista S, Fish D, Montgomery R, Fikrig E. Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks Journal Of Experimental Medicine 2011, 208: 1737-1737. PMCID: PMC3149219, DOI: 10.1084/jem.201002762088c.
  • Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticksSultana H, Neelakanta G, Kantor F, Malawista S, Fish D, Montgomery R, Fikrig E. Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks Journal Of Cell Biology 2010, 190: i8-i8. DOI: 10.1083/jcb1903oia8.
  • Functional Competence of Peritoneal Macrophages in Murine Lyme BorreliosisMontgomery R, Palmarozza R, Beck D, Ngo E, Joiner K, Malawista S. Functional Competence of Peritoneal Macrophages in Murine Lyme Borreliosis Inflammation 2000, 24: 277-288. DOI: 10.1023/a:1007017630980.

Clinical Trials

ConditionsStudy Title
Immune System; Men's Health; Women's HealthEffects of circadian regulation and sleep on immune responses
Addictive Behaviors; HIV/AIDS; Infectious DiseasesImpact of HIV Infection on Immunologic, Transcriptomic, and Metabolomic Signatures