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Inderjit Singh

MBChB, BMedSci, FRCP, FCCP

Assistant Professor; Director Pulmonary Vascular Program, Pulmonary, Critical Care & Sleep Medicine; Associate Program Director, Advanced Fellowship in Pulmonary Vascular Disease , Pulmonary, Critical Care, and Sleep Medicine

Research & Publications
Biography
News

Coauthors

Selected Publications

Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intoleranceKahn P, Joseph P, Heerdt P, Singh I. Differential cardiopulmonary haemodynamic phenotypes in PASC-related exercise intolerance. ERJ Open Research 2023, 10: 00714-2023. PMID: 38348243, PMCID: PMC10860209, DOI: 10.1183/23120541.00714-2023.
Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment.Tarras E, Khosla A, Heerdt P, Singh I. Right Heart Failure in the Intensive Care Unit: Etiology, Pathogenesis, Diagnosis, and Treatment. Journal Of Intensive Care Medicine 2023, 8850666231216889. PMID: 38031338, DOI: 10.1177/08850666231216889.
Post-Acute Sequelae of SARS-CoV-2 More Than DeconditioningJoseph P, Singh I. Post-Acute Sequelae of SARS-CoV-2 More Than Deconditioning. CHEST Journal 2023, 164: 583-584. PMID: 37689472, DOI: 10.1016/j.chest.2023.03.014.
Cognitive impairment in pulmonary arterial hypertensionHeller S, See C, Singh I, Fredericks C. Cognitive impairment in pulmonary arterial hypertension. Annals Of Clinical And Translational Neurology 2023, 10: 1899-1903. PMID: 37550957, PMCID: PMC10578884, DOI: 10.1002/acn3.51867.
High-Risk Pulmonary Embolism: Management for the IntensivistKhosla A, Zhao Y, Mojibian H, Pollak J, Singh I. High-Risk Pulmonary Embolism: Management for the Intensivist. Journal Of Intensive Care Medicine 2023, 38: 1087-1098. PMID: 37455352, DOI: 10.1177/08850666231188290.
Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical ApplicationHeerdt P, Martin-Flores M, Oakland H, Joseph P, Singh I. Integrating Right Ventricular Pressure Waveform Analysis With Two-Point Volume Measurement for Quantification of Systolic and Diastolic Function: Experimental Validation and Clinical Application. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 1929-1937. PMID: 37422337, PMCID: PMC10529383, DOI: 10.1053/j.jvca.2023.06.011.
Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery. 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During AgingYuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndromeSingh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.
Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not?Joseph P, Singh I, Oliveira R, Capone C, Mullen M, Cook D, Stovall M, Squires J, Madsen K, Waxman A, Systrom D. Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2 More in Common Than Not? CHEST Journal 2023, 164: 717-726. PMID: 37054777, PMCID: PMC10088277, DOI: 10.1016/j.chest.2023.03.049.
Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”Joseph P, Savarimuthu S, Oakland H, Cullinan M, Heerdt P, Singh I. Response to letter to the editor “noninvasive determinants of pulmonary hypertension in interstitial lung disease”. Pulmonary Circulation 2023, 13: e12238. PMID: 37180828, PMCID: PMC10166920, DOI: 10.1002/pul2.12238.
Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of ThrombolyticsSavarimuthu S, Singh I, Khosla A. Systemic Thrombolysis in Acute Pulmonary Embolism: Dose Considerations in Administration of Thrombolytics. 2023, 59-69. DOI: 10.1142/9781800612778_0005.
Cognitive impairment in pulmonary arterial hypertensionHeller S, See C, Singh I, Fredericks CA. (2023), Cognitive impairment in pulmonary arterial hypertension. Ann Clin Transl Neurol. https://doi.org/10.1002/acn3.51867
Noninvasive determinants of pulmonary hypertension in interstitial lung diseaseJoseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.
Short- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patientsSingh I, Joseph P. Short- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patients. European Respiratory Journal 2022, 61: 2201739. PMID: 36137592, PMCID: PMC9515479, DOI: 10.1183/13993003.01739-2022.
Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Singh I, Tellides G, Gill T, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary Artery. 2022, a5205-a5205. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5205.
Right Ventricular Capacitance in Pulmonary Arterial Hypertension and Heart Failure with Preserved Ejection FractionOakland H, Sugeng L, Joseph P, Izzi D, Zalik F, Raza A, Amendola R, Heerdt P, Singh I. Right Ventricular Capacitance in Pulmonary Arterial Hypertension and Heart Failure with Preserved Ejection Fraction. 2022, a4423-a4423. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4423.
Impaired Stressed Blood Volume Augmentation in Post-COVID-19 PatientsSavarimuthu S, Joseph P, Lutchmansingh D, Possick J, Gulati M, Cullinan M, Kreiger J, Heerdt P, Singh I. Impaired Stressed Blood Volume Augmentation in Post-COVID-19 Patients. 2022, a5418-a5418. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5418.
Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerationsKhosla A, Mojibian H, Assi R, Tantawy H, Singh I, Pollak J. Right heart thrombi (RHT) and clot in transit with concomitant PE management: Approach and considerations. Pulmonary Circulation 2022, 12: e12080. PMID: 35514771, PMCID: PMC9063956, DOI: 10.1002/pul2.12080.
Pressure‐based estimation of right ventricular ejection fractionHeerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure‐based estimation of right ventricular ejection fraction. ESC Heart Failure 2022, 9: 1436-1443. PMID: 35150211, PMCID: PMC8934966, DOI: 10.1002/ehf2.13839.
Reply to Grignola and TrujilloOakland HT, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Reply to Grignola and Trujillo. Journal Of Applied Physiology 2022, 132: 219-219. PMID: 35030044, PMCID: PMC8759952, DOI: 10.1152/japplphysiol.00810.2021.
Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implicationsHeerdt PM, Shelley B, Singh I. Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications. British Journal Of Anaesthesia 2021, 128: e246-e249. PMID: 35067364, PMCID: PMC8710396, DOI: 10.1016/j.bja.2021.12.036.
Abstract 10486: Single-Beat Estimation Right Ventricular End Diastolic Pressure RelationshipOakland H, Sugeng L, Joseph P, Amendola R, Crandall I, Raza A, Izzi D, Zalik F, Elassal A, Heerdt P, Singh I. Abstract 10486: Single-Beat Estimation Right Ventricular End Diastolic Pressure Relationship. Circulation 2021, 144: a10486-a10486. DOI: 10.1161/circ.144.suppl_1.10486.
Abstract 6991: Impaired Systemic Oxygen Extraction Relates to Reduced Exercise Capacity in Post-COVID-19 Long Hauler SyndromeBiondi M, Joseph P, Gulati M, Possick J, Lutchmansingh D, Cullinan M, Heerdt P, Singh I. Abstract 6991: Impaired Systemic Oxygen Extraction Relates to Reduced Exercise Capacity in Post-COVID-19 Long Hauler Syndrome. Circulation 2021, 144: a6991-a6991. DOI: 10.1161/circ.144.suppl_1.6991.
UNEXPLAINED DYSPNEA IN A PATIENT WITH A HISTORY OF COVID-19Biondi M, Gulati M, Possick J, Joseph P, Singh I, Lutchmansingh D. UNEXPLAINED DYSPNEA IN A PATIENT WITH A HISTORY OF COVID-19. CHEST Journal 2021, 160: a2373-a2374. PMCID: PMC8503500, DOI: 10.1016/j.chest.2021.07.2054.
Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic DataManning EP, Ramachandra AB, Schupp JC, Cavinato C, Raredon MSB, Bärnthaler T, Cosme C, Singh I, Tellides G, Kaminski N, Humphrey JD. Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data. Frontiers In Physiology 2021, 12: 726253. PMID: 34594238, PMCID: PMC8478173, DOI: 10.3389/fphys.2021.726253.
Chronic Thromboembolic Pulmonary Hypertension: the BedsideMatusov Y, Singh I, Yu YR, Chun HJ, Maron BA, Tapson VF, Lewis MI, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bedside. Current Cardiology Reports 2021, 23: 147. PMID: 34410530, PMCID: PMC8375459, DOI: 10.1007/s11886-021-01573-5.
Chronic Thromboembolic Pulmonary Hypertension: the BenchAlba GA, Atri D, Darbha S, Singh I, Tapson VF, Lewis MI, Chun HJ, Yu YR, Maron BA, Rajagopal S. Chronic Thromboembolic Pulmonary Hypertension: the Bench. Current Cardiology Reports 2021, 23: 141. PMID: 34410515, DOI: 10.1007/s11886-021-01572-6.
Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise TestingSingh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing. CHEST Journal 2021, 161: 54-63. PMID: 34389297, PMCID: PMC8354807, DOI: 10.1016/j.chest.2021.08.010.
Defining end-systolic pressure for single-beat estimation of right ventricle–pulmonary artery coupling: simple… but not reallySingh I, Oakland H, Elassal A, Heerdt PM. Defining end-systolic pressure for single-beat estimation of right ventricle–pulmonary artery coupling: simple… but not really. ERJ Open Research 2021, 7: 00219-2021. PMID: 34435035, PMCID: PMC8381254, DOI: 10.1183/23120541.00219-2021.
Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT ImagingRahaghi FN, Nardelli P, Harder E, Singh I, Sánchez-Ferrero GV, Ross JC, San José Estépar R, Ash SY, Hunsaker AR, Maron BA, Leopold JA, Waxman AB, San José Estépar R, Washko GR. Quantification of Arterial and Venous Morphologic Markers in Pulmonary Arterial Hypertension Using CT Imaging. CHEST Journal 2021, 160: 2220-2231. PMID: 34270966, PMCID: PMC8692106, DOI: 10.1016/j.chest.2021.06.069.
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertensionElassal A, Steppan J, Charania S, Santhanam L, Singh I, Heerdt PM. Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension. Journal Of Pharmacological And Toxicological Methods 2021, 112: 107102. PMID: 34245885, PMCID: PMC8616781, DOI: 10.1016/j.vascn.2021.107102.
Arterial load and right ventricular-vascular coupling in pulmonary hypertensionOakland H, Joseph P, Naeije R, Elassal A, Cullinan M, Heerdt PM, Singh I. Arterial load and right ventricular-vascular coupling in pulmonary hypertension. Journal Of Applied Physiology 2021, 131: 424-433. PMID: 34043473, PMCID: PMC8325619, DOI: 10.1152/japplphysiol.00204.2021.
Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from HypoxiaManning E, Ramachandra A, Schupp J, Cavinato C, Singh I, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Changes in Mouse Pulmonary Artery Resulting from Hypoxia. 2021, a3625-a3625. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3625.
Characteristic Impedance Affects Global Right Ventricular Function in Pulmonary Arterial Hypertension and Heart Failure with Preserved Ejection FractionOakland H, Joseph P, Elassal A, Cullinan M, Heerdt P, Singh I. Characteristic Impedance Affects Global Right Ventricular Function in Pulmonary Arterial Hypertension and Heart Failure with Preserved Ejection Fraction. 2021, a3690-a3690. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3690.
Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertensionNtokou A, Dave JM, Kauffman AC, Sauler M, Ryu C, Hwa J, Herzog EL, Singh I, Saltzman WM, Greif DM. Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension. JCI Insight 2021, 6: e139067. PMID: 33591958, PMCID: PMC8026182, DOI: 10.1172/jci.insight.139067.
Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertensionMessina CMS, Ferreira EVM, Singh I, Fonseca AXC, Ramos RP, Nery LE, Systrom DM, Oliveira RKF, Ota-Arakaki JS. Impact of right ventricular work and pulmonary arterial compliance on peak exercise oxygen uptake in idiopathic pulmonary arterial hypertension. International Journal Of Cardiology 2021, 331: 230-235. PMID: 33545265, DOI: 10.1016/j.ijcard.2021.01.027.
Pulmonary Hypertension in PregnancySingh I, Horn E, Haythe J. Pulmonary Hypertension in Pregnancy. Clinics In Chest Medicine 2021, 42: 91-99. PMID: 33541621, DOI: 10.1016/j.ccm.2020.10.006.
Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection FractionSingh I, Oliveira RKF, Heerdt PM, Pari R, Systrom DM, Waxman AB. Sex-Related Differences in Dynamic Right Ventricular-Pulmonary Vascular Coupling in Heart Failure With Preserved Ejection Fraction. CHEST Journal 2021, 159: 2402-2416. PMID: 33388286, DOI: 10.1016/j.chest.2020.12.028.
Abstract 17136: Pulmonary Arterial and Venous Fractal Dimension as a Marker of Pulmonary Arterial HypertensionTsao A, Nardelli P, Harder E, Vegas Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, Washko G, San Jose Estepar R, Rahaghi F. Abstract 17136: Pulmonary Arterial and Venous Fractal Dimension as a Marker of Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.17136.
Abstract 16667: Computed Tomography-Based Pulmonary Vascular Tortuosity as a Marker in Resting and Exercise Pulmonary Arterial HypertensionHarder E, Nardelli P, Sanchez-Ferrero G, Ross J, Ash S, Singh I, Hunsaker A, Waxman A, San Jose Estepar R, Washko G, Rahaghi F. Abstract 16667: Computed Tomography-Based Pulmonary Vascular Tortuosity as a Marker in Resting and Exercise Pulmonary Arterial Hypertension. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16667.
A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the FutureLutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future. CHEST Journal 2020, 159: 949-958. PMID: 33159907, PMCID: PMC7641526, DOI: 10.1016/j.chest.2020.10.067.
CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATIONFouad J, Singh I, Khosla A, Szabo C, Tantawy H, Razo-Vazquez A, Geirsson A, Bonde P, Fajardo E, Joseph P, Siner J, Chichra A. CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH COVID-19 WITH RESPIRATORY FAILURE REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION. CHEST Journal 2020, 158: a703-a704. PMCID: PMC7548617, DOI: 10.1016/j.chest.2020.08.660.
Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fractionOakland HT, Joseph P, Elassal A, Cullinan M, Heerdt PM, Singh I. Diagnostic utility of sub‐maximum cardiopulmonary exercise testing in the ambulatory setting for heart failure with preserved ejection fraction. Pulmonary Circulation 2020, 10: 1-10. PMID: 33282205, PMCID: PMC7691918, DOI: 10.1177/2045894020972273.
Systemic vascular distensibility relates to exercise capacity in connective tissue diseaseSingh I, Oliveira RKF, Naeije R, Oldham WM, Faria-Urbina M, Waxman AB, Systrom DM. Systemic vascular distensibility relates to exercise capacity in connective tissue disease. Rheumatology 2020, 60: 1429-1434. PMID: 33001175, DOI: 10.1093/rheumatology/keaa510.
A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of BreathWalia A, Singh I, Ryu C, Lutchmansingh DD. A 50-Year-Old Woman With Limited Scleroderma Presenting With Shortness of Breath. CHEST Journal 2020, 158: e37-e40. PMID: 32654737, PMCID: PMC8097629, DOI: 10.1016/j.chest.2020.02.041.
Dynamic right ventricular function response to incremental exercise in pulmonary hypertensionSingh I, Oliveira RKF, Heerdt P, Brown MB, Faria‐Urbina M, Waxman AB, Systrom DM. Dynamic right ventricular function response to incremental exercise in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-8. PMID: 33062259, PMCID: PMC7534091, DOI: 10.1177/2045894020950187.
Systemic Vascular Distensibility Predicts Exercise Capacity in Connective Tissue DiseaseSingh I, Oliveira R, Naeije R, Faria Urbina M, Waxman A, Systrom D. Systemic Vascular Distensibility Predicts Exercise Capacity in Connective Tissue Disease. 2020, a3240-a3240. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a3240.
A Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial HypertensionHeerdt P, Charania S, Elassal A, Singh I, Steppan J. A Pressure-Based Method for Estimation of Right Ventricular Ejection Fraction in a Rodent Model of Pulmonary Arterial Hypertension. 2020, a2086-a2086. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2086.
Right Ventricular-Pulmonary Vascular Uncoupling Threshold During Incremental ExerciseSingh I, Oliveira R, Brown M, Faria Urbina M, Waxman A, Systrom D. Right Ventricular-Pulmonary Vascular Uncoupling Threshold During Incremental Exercise. 2020, a2069-a2069. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2069.
Macrophage Platelet-Derived Growth Factor B Induces Smooth Muscle Cell Proliferation and Migration in Murine and Human Pulmonary HypertensionNtokou A, Dave J, Kauffman A, Hwa J, Herzog E, Singh I, Saltzman M, Greif D. Macrophage Platelet-Derived Growth Factor B Induces Smooth Muscle Cell Proliferation and Migration in Murine and Human Pulmonary Hypertension. 2020, a2677-a2677. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2677.
Precision Medicine in Pulmonary HypertensionSingh I, Oldham W, Rahaghi F. Precision Medicine in Pulmonary Hypertension. 2020, 241-255. DOI: 10.1007/978-3-030-31507-8_16.
A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of conceptHeerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. European Respiratory Journal 2019, 55: 1901635. PMID: 31771999, PMCID: PMC7885179, DOI: 10.1183/13993003.01635-2019.
Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertensionSingh I, Rahaghi F, Naeije R, Oliveira R, Vanderpool RR, Waxman A, Systrom D. Dynamic right ventricular–pulmonary arterial uncoupling during maximum incremental exercise in exercise pulmonary hypertension and pulmonary arterial hypertension. Pulmonary Circulation 2019, 9: 1-10. PMID: 31218910, PMCID: PMC6643191, DOI: 10.1177/2045894019862435.
Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary HypertensionSingh I, Oliveira RKF, Naeije R, Rahaghi FN, Oldham WM, Systrom DM, Waxman AB. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension. CHEST Journal 2019, 156: 724-732. PMID: 31121149, DOI: 10.1016/j.chest.2019.04.111.
Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular DysfunctionSingh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.
Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary HypertensionSingh I, Oliveira R, Naeije R, Rahaghi F, Oldham W, Systrom D, Waxman A. Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodelling in Pulmonary Hypertension. 2019, a3668-a3668. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3668.
Decrease in Intraparenchymal Small Vessel Fraction in Exercise Pulmonary Arterial HypertensionRahaghi F, de La Bruere I, Singh I, Nardelli P, Come C, Faria Urbina M, Leopold J, Hunsaker A, San José Estépar R, San José Estépar R, Systrom D, Waxman A, Washko G. Decrease in Intraparenchymal Small Vessel Fraction in Exercise Pulmonary Arterial Hypertension. 2019, a5590-a5590. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5590.
Main Pulmonary Artery Dilation in Early/Exercise Pulmonary HypertensionRuopp N, De La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Washko G, San Jose Estepar R, Systrom D, Waxman A, Rahaghi F. Main Pulmonary Artery Dilation in Early/Exercise Pulmonary Hypertension. 2019, a3664-a3664. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3664.
Right and Left Pulmonary Artery Dilation in Pulmonary HypertensionAnsari S, de La Bruere I, Singh I, Come C, Faria Urbina M, Leopold J, Hunsaker A, San Jose Estepar R, Washko G, Systrom D, Waxman A, Rahaghi F. Right and Left Pulmonary Artery Dilation in Pulmonary Hypertension. 2019, a3643-a3643. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3643.
MEF2 and the Right Ventricle: From Development to DiseaseClapham KR, Singh I, Capuano IS, Rajagopal S, Chun HJ. MEF2 and the Right Ventricle: From Development to Disease. Frontiers In Cardiovascular Medicine 2019, 6: 29. PMID: 30984767, PMCID: PMC6448530, DOI: 10.3389/fcvm.2019.00029.
Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer.Shojaee S, Singh I, Solsky I, Nana-Sinkam P. Malignant Pleural Effusion at Presentation in Patients with Small-Cell Lung Cancer. Respiration; International Review Of Thoracic Diseases 2019, 98: 198-202. PMID: 31121583, DOI: 10.1159/000499372.
Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEFSingh I, Rahaghi F, Oliveira R, Systrom D, Waxman A. Dynamic right ventricular-pulmonary arterial (RV-PA) uncoupling during incremental exercise in HFpEF. 2018, pa3313. DOI: 10.1183/13993003.congress-2018.pa3313.
Pulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case seriesSingh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary extra‐medullary hematopoiesis and pulmonary hypertension from underlying polycythemia vera: a case series. Pulmonary Circulation 2017, 7: 261-267. PMID: 28680586, PMCID: PMC5448544, DOI: 10.1177/2045893217702064.
A Woman with Asthma and Ground-Glass OpacitiesSingh I, Kaner R. A Woman with Asthma and Ground-Glass Opacities. Annals Of The American Thoracic Society 2017, 14: 140-144. PMID: 28035877, DOI: 10.1513/annalsats.201606-473cc.
Pulmonary Extra-medullary Hematopoiesis and Pulmonary Hypertension From Underlying Polycythemia Vera: A Case Series.Singh I, Mikita G, Green D, Risquez C, Sanders A. Pulmonary Extra-medullary Hematopoiesis and Pulmonary Hypertension From Underlying Polycythemia Vera: A Case Series. Pulmonary Circulation 2016 DOI: 10.1086/690730.
When the JAK Fails the PumpSingh I, Risquez C, Sanders A. When the JAK Fails the Pump. CHEST Journal 2016, 150: 687a. DOI: 10.1016/j.chest.2016.08.782.
Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung DiseaseSingh I, Cong K, Berlin DA. Pathophysiology of Pulmonary Hypertension in Chronic Parenchymal Lung Disease. The American Journal Of Medicine 2015, 129: 366-371. PMID: 26706386, DOI: 10.1016/j.amjmed.2015.11.026.
Pulmonary Nocardiosis in the Immunocompetent Host: Case SeriesSingh I, West F, Sanders A, Hartman B, Zappetti D. Pulmonary Nocardiosis in the Immunocompetent Host: Case Series. Case Reports In Pulmonology 2015, 2015: 314831. PMID: 26491594, PMCID: PMC4605260, DOI: 10.1155/2015/314831.
Exercise Intolerance in Pulmonary HypertensionSingh I, Zappetti D. Exercise Intolerance in Pulmonary Hypertension. Clinical Pulmonary Medicine 2015, 22: 258-259. DOI: 10.1097/cpm.0000000000000122.
A Technique for Bronchoscopic Intubation During High-Flow Nasal Cannula Oxygen TherapyBerlin D, Singh I, Barjaktarevic I, Friedman O. A Technique for Bronchoscopic Intubation During High-Flow Nasal Cannula Oxygen Therapy. Journal Of Intensive Care Medicine 2015, 31: 213-215. PMID: 25911299, DOI: 10.1177/0885066615582020.

Clinical Trials

Conditions	Study Title
Diseases of the Cardiovascular System; Hypertension	A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16) (CADENCE)
Diseases of the Cardiovascular System	A Phase 2a Study of LAM-001 for the Treatment of Pulmonary Hypertension

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Inderjit Singh

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