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INFORMATION FOR

Maurizio Chioccioli

PhD, MSc, BSc
Assistant Professor of Medicine (Pulmonary, Critical Care and Sleep Medicine)

Research Summary

My research interest is to apply quantitative imaging and next-generation technologies to understand the pathophysiology and molecular etiology of respiratory disease. My experience and expertise span multiple areas from biophysics and live-imaging microscopy to molecular biology, genetics and human respiratory diseases. I combine novel in vivo quantitative imaging approaches, genetic mouse models and next-generation omics technologies to understand the molecular and cellular mechanisms that drive successful alveolar repair.

Research Interests

Alveolar Process; Ciliary Motility Disorders; Lung Injury; Alveolar Epithelial Cells; Intravital Microscopy

Selected Publications

  • Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung InjuryChioccioli M, Mcdonough J, Yang T, Gonzalez D, Rivera-Molina F, Kaminski N, Sauler M, DeIuliis G. Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung Injury 2022, a5477-a5477. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5477.
  • Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta AgonistBaernthaler T, Ding S, Chioccioli M, Poli F, Justet A, Rose K, Cosme Jr. C, Adams T, Ahangari F, Rosas I, Kaminski N. Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta Agonist 2022, a3722-a3722. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3722.
  • Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPDMcDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme Jr. C, Poli De Frias S, Ayaub E, Chu S, Jensen K, Gomez J, Britto-Leon C, Raredon M, Niklason L, Timshel P, Kaminski N, Rosas I, Sauler M. Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD 2021, a4281-a4281. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4281.
  • Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of LymphocytesAdams T, Schupp J, Mcdonough J, Chioccioli M, Rose K, DeIuliis G, Yan X, Kaminski N. Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of Lymphocytes 2021, a4351-a4351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4351.
  • Macrophage Specific Regulatory Role of miR-33 in Pulmonary FibrosisAhangari F, Chioccioli M, Malik S, Baernthaler T, Price N, Ding S, Rose K, Mcdonough J, Omote N, Schupp J, Adams T, Sharma L, DeIuliis G, Dela Cruz C, Prasse A, Bahal R, Fernandez-Hernando C, Kaminski N. Macrophage Specific Regulatory Role of miR-33 in Pulmonary Fibrosis 2021, a4452-a4452. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4452.
  • The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary FibrosisBaernthaler T, Ahangari F, Chioccioli M, Adams T, Rose K, Ding S, Kaminski N. The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary Fibrosis 2021, a4449-a4449. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4449.
  • Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor ReceptorHarris Z, Chioccioli M, Joerns J, Clark B, Sun Y, Hu B, Stanley G, Rajagopalan G, Koff J. Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor Receptor 2020, a5551-a5551. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5551.
  • Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Hashimoto N, Hasegawa Y, Kaminski N. Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell Differentiation 2020, a5987-a5987. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5987.
  • Saracatinib Is a Potential Novel Therapeutic for Pulmonary FibrosisAhangari F, Becker C, Foster D, Chioccioli M, Nelson M, Beke K, Meador C, Wang X, Corell K, Roybal H, DeIuliis G, Rose K, Schupp J, Li Q, Adams T, Aschner Y, Lilli L, Readhead B, Cousens L, Dudley J, Kaminski N, Downey G. Saracatinib Is a Potential Novel Therapeutic for Pulmonary Fibrosis 2020, a2784-a2784. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2784.
  • Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBDEverman J, Jackson N, Sajuthi S, Saef B, Chioccioli M, Dyjack N, Powell R, Rios C, Montgomery M, Oh S, Eng C, Elhawary J, Feriani L, Armstrong M, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Rodriguez-Santana J, Reisdorph N, Burchard E, Seibold M. Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD 2020, a7400-a7400. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7400.
  • Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic InjuryLi Q, Omote N, Adams T, Chioccioli M, Shakya A, DeIuliis G, Herzog E, Tantin D, Herazo-Maya J, Kaminski N. Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic Injury 2019, a2827-a2827. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2827.
  • Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell PopulationSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, Omote N, Chioccioli M, Xylourgidis N, DeIuliis G, Chu S, Yan X, Rosas I, Kaminski N. Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population 2019, a4017-a4017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4017.
  • TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Xylourgidis N, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation 2019, a5406-a5406. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5406.
  • Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell S, Mennella V, Amirav I, Cicuta P. Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary Dyskinesia 2019, a5883-a5883. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5883.