Maurizio Chioccioli, PhD

• Buqu Hu
• Carlos Fernandez-Hernando
• Clemente Britto-Leon
• Edward Manning
• Farida Ahangari
• Gail Stanley
• Govind Rajagopalan
• Jessica Nouws
• Jon Koff
• Jonas Christian Schupp
• Lokesh Kumar Sharma
• Maor Sauler
• Micha Sam Brickman Raredon
• Naftali Kaminski
• Qin Li
• Richard Pierce
• Robert Homer
• Taylor Adams
• Wonnie Ryu
• Xiting Yan

Alveolar Process; Lung Injury; Alveolar Epithelial Cells; Intravital Microscopy

• microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosisAhangari F, Price N, Malik S, Chioccioli M, Bärnthaler T, Adams T, Kim J, Pradeep S, Ding S, Cosme C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp J, DeIuliis G, Nunez J, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis. JCI Insight 2023, 8: e158100. PMID: 36626225, PMCID: PMC9977502, DOI: 10.1172/jci.insight.158100.
• Phototaxis of Chlamydomonas arises from a tuned adaptive photoresponse shared with multicellular Volvocine green algaeLeptos K, Chioccioli M, Furlan S, Pesci A, Goldstein R. Phototaxis of Chlamydomonas arises from a tuned adaptive photoresponse shared with multicellular Volvocine green algae. Physical Review E 2023, 107: 014404. PMID: 36797913, DOI: 10.1103/physreve.107.014404.
• Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1463-1479. PMID: 35998281, PMCID: PMC9757097, DOI: 10.1164/rccm.202010-3832oc.
• A lung targeted miR-29 mimic as a therapy for pulmonary fibrosisChioccioli M, Roy S, Newell R, Pestano L, Dickinson B, Rigby K, Herazo-Maya J, Jenkins G, Ian S, Saini G, Johnson SR, Braybrooke R, Yu G, Sauler M, Ahangari F, Ding S, DeIuliis J, Aurelien N, Montgomery RL, Kaminski N. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis. EBioMedicine 2022, 85: 104304. PMID: 36265417, PMCID: PMC9587275, DOI: 10.1016/j.ebiom.2022.104304.
• Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung InjuryChioccioli M, Mcdonough J, Yang T, Gonzalez D, Rivera-Molina F, Kaminski N, Sauler M, DeIuliis G. Live Imaging the Dynamic Spatiotemporal Behavior of Alveolar Type 2 Cells in Response to Bleomycin Induced Lung Injury. 2022, a5477-a5477. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5477.
• Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta AgonistBaernthaler T, Ding S, Chioccioli M, Poli F, Justet A, Rose K, Cosme Jr. C, Adams T, Ahangari F, Rosas I, Kaminski N. Antifibrotic Effects of Sobetirome, a Thyroid Hormone Receptor Beta Agonist. 2022, a3722-a3722. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3722.
• Characterization of the COPD alveolar niche using single-cell RNA sequencingSauler M, McDonough JE, Adams TS, Kothapalli N, Barnthaler T, Werder RB, Schupp JC, Nouws J, Robertson MJ, Coarfa C, Yang T, Chioccioli M, Omote N, Cosme C, Poli S, Ayaub EA, Chu SG, Jensen KH, Gomez JL, Britto CJ, Raredon MSB, Niklason LE, Wilson AA, Timshel PN, Kaminski N, Rosas IO. Characterization of the COPD alveolar niche using single-cell RNA sequencing. Nature Communications 2022, 13: 494. PMID: 35078977, PMCID: PMC8789871, DOI: 10.1038/s41467-022-28062-9.
• Integrated Single Cell Atlas of Endothelial Cells of the Human LungSchupp JC, Adams TS, Cosme C, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe’er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Integrated Single Cell Atlas of Endothelial Cells of the Human Lung. Circulation 2021, 144: 286-302. PMID: 34030460, PMCID: PMC8300155, DOI: 10.1161/circulationaha.120.052318.
• Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPDMcDonough J, Adams T, Kothapalli N, Schupp J, Nouws J, Chioccioli M, Omote N, Cosme Jr. C, Poli De Frias S, Ayaub E, Chu S, Jensen K, Gomez J, Britto-Leon C, Raredon M, Niklason L, Timshel P, Kaminski N, Rosas I, Sauler M. Decreased NUPR1 in AT2 Cells Is Associated with Development of Emphysema in COPD. 2021, a4281-a4281. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4281.
• Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of LymphocytesAdams T, Schupp J, Mcdonough J, Chioccioli M, Rose K, DeIuliis G, Yan X, Kaminski N. Integrated scRNAseq Analysis of Murine Lung Fibrosis Reveals Patterns in Composition and Gene Expression of Lymphocytes. 2021, a4351-a4351. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4351.
• Macrophage Specific Regulatory Role of miR-33 in Pulmonary FibrosisAhangari F, Chioccioli M, Malik S, Baernthaler T, Price N, Ding S, Rose K, Mcdonough J, Omote N, Schupp J, Adams T, Sharma L, DeIuliis G, Dela Cruz C, Prasse A, Bahal R, Fernandez-Hernando C, Kaminski N. Macrophage Specific Regulatory Role of miR-33 in Pulmonary Fibrosis. 2021, a4452-a4452. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4452.
• The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary FibrosisBaernthaler T, Ahangari F, Chioccioli M, Adams T, Rose K, Ding S, Kaminski N. The Thyroid Hormone Receptor Beta Agonist Sobetirome Exerts Beneficial Effects in Pulmonary Fibrosis. 2021, a4449-a4449. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4449.
• Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation stateOmote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.
• MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary diseaseNouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.
• Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High AsthmaJackson ND, Everman JL, Chioccioli M, Feriani L, Goldfarbmuren KC, Sajuthi SP, Rios CL, Powell R, Armstrong M, Gomez J, Michel C, Eng C, Oh SS, Rodriguez-Santana J, Cicuta P, Reisdorph N, Burchard EG, Seibold MA. Single-Cell and Population Transcriptomics Reveal Pan-epithelial Remodeling in Type 2-High Asthma. Cell Reports 2020, 32: 107872. PMID: 32640237, PMCID: PMC8046336, DOI: 10.1016/j.celrep.2020.107872.
• Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor ReceptorHarris Z, Chioccioli M, Joerns J, Clark B, Sun Y, Hu B, Stanley G, Rajagopalan G, Koff J. Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor Receptor. 2020, a5551-a5551. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5551.
• Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Hashimoto N, Hasegawa Y, Kaminski N. Long Non-Coding RNA TINCR Is a Novel Regulator of Human Bronchial Epithelial Cell Differentiation. 2020, a5987-a5987. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5987.
• Saracatinib Is a Potential Novel Therapeutic for Pulmonary FibrosisAhangari F, Becker C, Foster D, Chioccioli M, Nelson M, Beke K, Meador C, Wang X, Corell K, Roybal H, DeIuliis G, Rose K, Schupp J, Li Q, Adams T, Aschner Y, Lilli L, Readhead B, Cousens L, Dudley J, Kaminski N, Downey G. Saracatinib Is a Potential Novel Therapeutic for Pulmonary Fibrosis. 2020, a2784-a2784. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2784.
• Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBDEverman J, Jackson N, Sajuthi S, Saef B, Chioccioli M, Dyjack N, Powell R, Rios C, Montgomery M, Oh S, Eng C, Elhawary J, Feriani L, Armstrong M, Gomez J, Zhang X, Medina V, Chu H, Cicuta P, Rodriguez-Santana J, Reisdorph N, Burchard E, Seibold M. Intelectin-1 Affects Interleukin-13-Induced Mucociliary Airway Dysfunction and Its Expression Is Regulated by a Cis-eQTL Associated with Development of Asthma and IBD. 2020, a7400-a7400. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7400.
• Quantitative High-Speed Video Profiling Discriminates between DNAH11 and HYDIN Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SD, Mennella V, Amirav I, Cicuta P. Quantitative High-Speed Video Profiling Discriminates between DNAH11 and HYDIN Variants of Primary Ciliary Dyskinesia. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1436-1438. PMID: 31116566, DOI: 10.1164/rccm.201812-2256le.
• Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic InjuryLi Q, Omote N, Adams T, Chioccioli M, Shakya A, DeIuliis G, Herzog E, Tantin D, Herazo-Maya J, Kaminski N. Pou2af1 Is a Novel Regulator of Airway EpithelialCells Differentiation and Response to Fibrotic Injury. 2019, a2827-a2827. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2827.
• Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell PopulationSchupp J, Adams T, Neumark N, Poli De Frias S, Ahangari F, Omote N, Chioccioli M, Xylourgidis N, DeIuliis G, Chu S, Yan X, Rosas I, Kaminski N. Whole Lung Single Cell RNAseq Reveals a Unique IPF-Specific Epithelial Cell Population. 2019, a4017-a4017. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4017.
• TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell DifferentiationOmote N, Sakamoto K, Li Q, Schupp J, Adams T, Ahangari F, Chioccioli M, Xylourgidis N, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. TINCR, a Long Intergenic Noncoding RNA Decreased in IPF, Is a Novel Regulator of Airway Epithelial Cell Differentiation. 2019, a5406-a5406. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5406.
• Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell S, Mennella V, Amirav I, Cicuta P. Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary Dyskinesia. 2019, a5883-a5883. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5883.
• Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cellsChioccioli M, Feriani L, Kotar J, Bratcher PE, Cicuta P. Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells. Nature Communications 2019, 10: 1763. PMID: 30992452, PMCID: PMC6467870, DOI: 10.1038/s41467-019-09798-3.
• A How-To guide to: Quantitative high-speed video profiling to discriminate between variants of primary ciliary dyskinesiahttps://doi.org/10.1101/614966
• Assessing the Collective Dynamics of Motile Cilia in Cultures of Human Airway Cells by Multiscale DDMFeriani L, Juenet M, Fowler CJ, Bruot N, Chioccioli M, Holland SM, Bryant CE, Cicuta P. Assessing the Collective Dynamics of Motile Cilia in Cultures of Human Airway Cells by Multiscale DDM. Biophysical Journal 2017, 113: 109-119. PMID: 28700909, PMCID: PMC5510766, DOI: 10.1016/j.bpj.2017.05.028.
• Phototaxis beyond turning: persistent accumulation and response acclimation of the microalga Chlamydomonas reinhardtiiArrieta J, Barreira A, Chioccioli M, Polin M, Tuval I. Phototaxis beyond turning: persistent accumulation and response acclimation of the microalga Chlamydomonas reinhardtii. Scientific Reports 2017, 7: 3447. PMID: 28615673, PMCID: PMC5471259, DOI: 10.1038/s41598-017-03618-8.
• Flow Cytometry Pulse Width Data Enables Rapid and Sensitive Estimation of Biomass Dry Weight in the Microalgae Chlamydomonas reinhardtii and Chlorella vulgarisChioccioli M, Hankamer B, Ross IL. Flow Cytometry Pulse Width Data Enables Rapid and Sensitive Estimation of Biomass Dry Weight in the Microalgae Chlamydomonas reinhardtii and Chlorella vulgaris. PLOS ONE 2014, 9: e97269. PMID: 24832156, PMCID: PMC4022489, DOI: 10.1371/journal.pone.0097269.