David A. Hafler, MD, FANA
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Research Summary
Hafler, in many respects, is credited with identifying the central mechanisms underlying the likely cause of MS. His early seminal work demonstrated that the disease began in the blood, not the brain, which eventually led to the development of Tysabri to treat the disease by blocking the movement of immune cells from the blood to the brain. He was the first to identify myelin-reactive T cells in the disease, published in Nature, showing that indeed, MS was an autoimmune disorder. He then went on to show why autoreactive T cells were dysregulated by the first identification of regulatory T cells in humans followed by demonstration of their dysfunctional state in MS. As a founding, Broad Institute member, Hafler identified the genes that cause MS, published in the New England Journal of Medicine and Nature. More recently, he identified the key transcription factors and signaling pathways associated with MS genes as potential treatment targets. Finally, he recently discovered that salt drives induction of these pathogenic myelin reactive T cells, both works published in Nature. Hafler was the Breakstone Professor of Neuroscience at Harvard, and became Chairman of Neurology at Yale in 2009, where he has built an outstanding clinical and research program that strongly integrates medical sciences. He has received numerous honors including the Dystel Prize from the AAN for his MS research and is among the most highly cited living neurologists and is a member of the National Academy of Medicine.
Specialized Terms: Neuroimmunology; Multiple Sclerosis; Autoimmunity; Genetics; Immunobiology
Extensive Research Description
Hafler is a major force in bridging basic immunology, genetics, and neurology deeply probing mechanisms to understand MS. His seminal work in 1985 demonstrating systemic immune involvement in MS (NEJM, 1985) was followed by the first identification of myelin, autoreactive T cells in MS (Nature 1990). In 2004, Hafler was the first to identify human FoxP3 regulatory T cells and then demonstrated that they are defective in MS (JEM, Nature Med, 2011). In 2001, he co-led the international effort that identified the first MS genes outside of MHC (NEJM, 2007) now with over 100 identified genes (Nature 2011). In 2009 Hafler was recruited to become Chairman of Yale Neurology and Professor of Neurology and Immunobiology where he has rapidly built an outstanding clinical program that strongly integrates medical sciences. His scientific leadership has continued where he has deeply examined the function of MS associated risk haplotypes demonstrating their significant biologic effects (JCI 2014), identified NaCl as an environmental cause of of inflammation (Nature 2013), and epigentically fine-mapped MS causal variants discovering the molecular pathways causing MS (Nature 2014). He has received innumerable professional distinctions including being becoming a Jacob Javits Scholar of the NIH, ASCI membership, the ISI most highly cited list, the University of Miami Distinguished Alumni Award and the prestigious John Dystel Prize from the American Academy of Neurology and is a member of the National Academy of Medicine.
Coauthors
Research Interests
Brain Neoplasms; Multiple Sclerosis; Neurology; Neurosciences; Autoimmunity
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics; HIV/AIDS; Immunology; Nutrition
Selected Publications
- Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine ProtectionKim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan J, Buitrago‐Pocasangre N, Lele N, Asashima H, Racke M, Wilson J, Givens T, Tomayko M, Schulz W, Longbrake E, Hafler D, Halene S, Fan R. Microfluidic Immuno‐Serolomic Assay Reveals Systems Level Association with COVID‐19 Pathology and Vaccine Protection. Small Methods 2023, e2300594. PMID: 37312418, DOI: 10.1002/smtd.202300594.
- Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patientsDiray-Arce J, Fourati S, Jayavelu N, Patel R, Maguire C, Chang A, Dandekar R, Qi J, Lee B, van Zalm P, Schroeder A, Chen E, Konstorum A, Brito A, Gygi J, Kho A, Chen J, Pawar S, Gonzalez-Reiche A, Hoch A, Milliren C, Overton J, Westendorf K, Network I, Abraham J, Adkisson M, Albert M, Torres L, Alvarenga B, Anderson M, Anderson E, Arnett A, Asashima H, Atkinson M, Baden L, Barton B, Beach K, Beagle E, Becker P, Bell M, Bernui M, Bime C, Kumar A, Booth L, Borresen B, Brakenridge S, Bristow L, Bryant R, Calfee C, Manuel J, Carrillo S, Chak S, Chang I, Connors J, Conway M, Corry D, Cowan D, Croen B, Dela Cruz C, Cusimano G, Eaker L, Edwards C, Ehrlich L, Elashoff D, Erickson H, Erle D, Farhadian S, Farrugia K, Fatou B, Fernandes A, Fernandez-Sesma A, Fragiadakis G, Furukawa S, Geltman J, Ghale R, Bermúdez M, Goonewardene M, Sanchez E, Guirgis F, Hafler D, Hamilton S, Harris P, Nemati A, Hendrickson C, Agudelo N, Hodder T, Holland S, Hough C, Huerta C, Hurley K, Hutton S, Iwasaki A, Jauregui A, Jha M, Johnson B, Joyner D, Kangelaris K, Kelly G, Khalil Z, Khan Z, Kheradmand F, Kim J, Kimura H, Ko A, Kohr B, Kraft M, Krummel M, Kutzler M, Lasky-Su J, Lee S, Lee D, Leipold M, Lentucci C, Leroux C, Lin E, Liu S, Love C, Lu Z, Maliskova L, Roth B, Manohar M, Martens M, McComsey G, McEnaney K, McLin R, Melamed E, Melnyk N, Mendez K, Messer W, Metcalf J, Michelotti G, Mick E, Mohanty S, Mosier J, Mulder L, Murphy M, Nadeau K, Nelson E, Nelson A, Nguyen V, Oberhaus J, Panganiban B, Pellegrini K, Pickering H, Powell D, Presnell S, Pulendran B, Rahman A, Sadeed A, Raskin A, Reed E, Pereira S, Rivera A, Rogers J, Rogers A, Rogowski B, Rooks R, Rosenberg-Hasson Y, Rothman J, Rousseau J, Salehi-Rad R, Saluvan M, Samaha H, Schaenman J, Schunk R, Semenza N, Sen S, Sevransky J, Seyfert-Margolis V, Shaheen T, Shaw A, Sieg S, Siegel S, Sigal N, Siles N, Simmons B, Simon V, Singh G, Sinko L, Smith C, Smolen K, Song L, Srivastava K, Sullivan P, Syphurs C, Tcheou J, Tegos G, Tharp G, Ally A, Tsitsiklis A, Ungaro R, Vaysman T, Viode A, Vita R, Wang X, Ward A, Ward D, Willmore A, Woloszczuk K, Wong K, Woodruff P, Xu L, van Haren S, van de Guchte A, Zhao Y, Cairns C, Rouphael N, Bosinger S, Kim-Schulze S, Krammer F, Rosen L, Grubaugh N, van Bakel H, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier C, Levy O, Altman M, Maecker H, Montgomery R, Haddad E, Sekaly R, Esserman D, Ozonoff A, Becker P, Augustine A, Guan L, Peters B, Kleinstein S. Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Reports Medicine 2023, 4: 101079. PMID: 37327781, PMCID: PMC10203880, DOI: 10.1016/j.xcrm.2023.101079.
- Common genetic factors among autoimmune diseasesHarroud A, Hafler D. Common genetic factors among autoimmune diseases. Science 2023, 380: 485-490. PMID: 37141355, DOI: 10.1126/science.adg2992.
- Regulatory T cells in peripheral tissue tolerance and diseasesCheru N, Hafler D, Sumida T. Regulatory T cells in peripheral tissue tolerance and diseases. Frontiers In Immunology 2023, 14: 1154575. PMID: 37197653, PMCID: PMC10183596, DOI: 10.3389/fimmu.2023.1154575.
- Overproduction of Pro-inflammatory Cytokines in New-Onset Refractory Status Epilepticus (NORSE) (S35.002)Hanin A, Cespedes J, Dorgham K, Gopaul M, Hafler D, Navarro V, Gaspard N, Hirsch L. Overproduction of Pro-inflammatory Cytokines in New-Onset Refractory Status Epilepticus (NORSE) (S35.002). 2023, 4087. DOI: 10.1212/wnl.0000000000203729.
- Cytokines in New‐Onset Refractory Status Epilepticus Predict OutcomesHanin A, Cespedes J, Dorgham K, Pulluru Y, Gopaul M, Gorochov G, Hafler D, Navarro V, Gaspard N, Hirsch L. Cytokines in New‐Onset Refractory Status Epilepticus Predict Outcomes. Annals Of Neurology 2023, 94: 75-90. PMID: 36871188, DOI: 10.1002/ana.26627.
- High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seqLiu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Nam J, Gao F, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft J, Hafler D, Fan R. High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq. Nature Biotechnology 2023, 1-5. PMID: 36823353, DOI: 10.1038/s41587-023-01676-0.
- Sodium perturbs mitochondrial respiration and induces dysfunctional TregsCôrte-Real B, Hamad I, Arroyo Hornero R, Geisberger S, Roels J, Van Zeebroeck L, Dyczko A, van Gisbergen M, Kurniawan H, Wagner A, Yosef N, Weiss S, Schmetterer K, Schröder A, Krampert L, Haase S, Bartolomaeus H, Hellings N, Saeys Y, Dubois L, Brenner D, Kempa S, Hafler D, Stegbauer J, Linker R, Jantsch J, Müller D, Kleinewietfeld M. Sodium perturbs mitochondrial respiration and induces dysfunctional Tregs. Cell Metabolism 2023, 35: 299-315.e8. PMID: 36754020, DOI: 10.1016/j.cmet.2023.01.009.
- Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activityShinoda K, Li R, Rezk A, Mexhitaj I, Patterson K, Kakara M, Zuroff L, Bennett J, von Büdingen H, Carruthers R, Edwards K, Fallis R, Giacomini P, Greenberg B, Hafler D, Ionete C, Kaunzner U, Lock C, Longbrake E, Pardo G, Piehl F, Weber M, Ziemssen T, Jacobs D, Gelfand J, Cross A, Cameron B, Musch B, Winger R, Jia X, Harp C, Herman A, Bar-Or A. Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2207291120. PMID: 36634138, PMCID: PMC9934304, DOI: 10.1073/pnas.2207291120.
- PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infectionAsashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein S, Montgomery R, Iwasaki A, Dela Cruz C, Kaminski N, Shaw A, Hafler D, Sumida T. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection. Cell Reports 2023, 42: 111895. PMID: 36596303, PMCID: PMC9806868, DOI: 10.1016/j.celrep.2022.111895.
- A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cellsAxisa P, Yoshida T, Lucca L, Kasler H, Lincoln M, Pham G, Del Priore D, Carpier J, Lucas C, Verdin E, Sumida T, Hafler D. A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science Translational Medicine 2022, 14: eabl3651. PMID: 36516268, DOI: 10.1126/scitranslmed.abl3651.
- Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failureQu R, Kluger Y, Yang J, Zhao J, Hafler D, Krause D, Bersenev A, Bosenberg M, Hurwitz M, Lucca L, Kluger H. Longitudinal single-cell analysis of a patient receiving adoptive cell therapy reveals potential mechanisms of treatment failure. Molecular Cancer 2022, 21: 219. PMID: 36514045, PMCID: PMC9749221, DOI: 10.1186/s12943-022-01688-5.
- Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosisAsashima H, Axisa PP, Pham THG, Longbrake EE, Ruff WE, Lele N, Cohen I, Raddassi K, Sumida TS, Hafler DA. Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis. Journal Of Clinical Investigation 2022, 132: e156254. PMID: 36250467, PMCID: PMC9566906, DOI: 10.1172/jci156254.
- Neuroimmune interactions in health and diseaseHafler DA, Sansing LH. Neuroimmune interactions in health and disease. Seminars In Immunopathology 2022, 44: 565-567. PMID: 36171280, DOI: 10.1007/s00281-022-00963-3.
- Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity.Kim D, Biancon G, Bai Z, VanOudenhove J, Liu Y, Kothari S, Gowda L, Kwan JM, Buitrago-Pocasangre NC, Lele N, Asashima H, Racke MK, Wilson JE, Givens TS, Tomayko MM, Schulz WL, Longbrake EE, Hafler DA, Halene S, Fan R. Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity. BioRxiv : The Preprint Server For Biology 2022 PMID: 36093346, PMCID: PMC9460970, DOI: 10.1101/2022.08.31.506117.
- The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndromeLongbrake EE, Hua LH, Mowry EM, Gauthier SA, Alvarez E, Cross AH, Pei J, Priest J, Raposo C, Hafler DA, Winger RC. The CELLO trial: Protocol of a planned phase 4 study to assess the efficacy of Ocrelizumab in patients with radiologically isolated syndrome. Multiple Sclerosis And Related Disorders 2022, 68: 104143. PMID: 36031693, PMCID: PMC9772048, DOI: 10.1016/j.msard.2022.104143.
- Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC studyOzonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein SH, Levy O, Bime C, Haddad EK, Erle DJ, Pulendran B, Nadeau KC, Davis MM, Hough CL, Messer WB, Higuita NIA, Metcalf JP, Atkinson MA, Brakenridge SC, Corry D, Kheradmand F, Ehrlich LIR, Melamed E, McComsey GA, Sekaly R, Diray-Arce J, Peters B, Augustine AD, Reed EF, Altman MC, Becker PM, Rouphael N, Ozonoff A, Schaenman J, Jayavelu N, Milliren C, Calfee C, Cairns C, Kraft M, Baden L, Shaw A, Krammer F, van Bakel H, Esserman D, Liu S, Sesma A, Simon V, Hafler D, Montgomery R, Kleinstein S, Levy O, Bime C, Haddad E, Erle D, Pulendran B, Nadeau K, Davis M, Hough C, Messer W, Higuita N, Metcalf J, Atkinson M, Brakenridge S, Corry D, Kheradmand F, Ehrlich L, Melamed E, McComsey G, Sekaly R, Diray-Arce J, Peters B, Augustine A, Reed E, McEnaney K, Barton B, Lentucci C, Saluvan M, Chang A, Hoch A, Albert M, Shaheen T, Kho A, Thomas S, Chen J, Murphy M, Cooney M, Presnell S, Fragiadakis G, Patel R, Guan L, Gygi J, Pawar S, Brito A, Khalil Z, Maguire C, Fourati S, Overton J, Vita R, Westendorf K, Salehi-Rad R, Leligdowicz A, Matthay M, Singer J, Kangelaris K, Hendrickson C, Krummel M, Langelier C, Woodruff P, Powell D, Kim J, Simmons B, Goonewardene I, Smith C, Martens M, Mosier J, Kimura H, Sherman A, Walsh S, Issa N, Dela Cruz C, Farhadian S, Iwasaki A, Ko A, Chinthrajah S, Ahuja N, Rogers A, Artandi M, Siegel S, Lu Z, Drevets D, Brown B, Anderson M, Guirgis F, Thyagarajan R, Rousseau J, Wylie D, Busch J, Gandhi S, Triplett T, Yendewa G, Giddings O, Anderson E, Mehta A, Sevransky J, Khor B, Rahman A, Stadlbauer D, Dutta J, Xie H, Kim-Schulze S, Gonzalez-Reiche A, van de Guchte A, Farrugia K, Khan Z, Maecker H, Elashoff D, Brook J, Ramires-Sanchez E, Llamas M, Rivera A, Perdomo C, Ward D, Magyar C, Fulcher J, Abe-Jones Y, Asthana S, Beagle A, Bhide S, Carrillo S, Chak S, Fragiadakis G, Ghale R, Gonzalez A, Jauregui A, Jones N, Lea T, Lee D, Lota R, Milush J, Nguyen V, Pierce L, Prasad P, Rao A, Samad B, Shaw C, Sigman A, Sinha P, Ward A, Willmore A, Zhan J, Rashid S, Rodriguez N, Tang K, Altamirano L, Betancourt L, Curiel C, Sutter N, Paz M, Tietje-Ulrich G, Leroux C, Connors J, Bernui M, Kutzler M, Edwards C, Lee E, Lin E, Croen B, Semenza N, Rogowski B, Melnyk N, Woloszczuk K, Cusimano G, Bell M, Furukawa S, McLin R, Marrero P, Sheidy J, Tegos G, Nagle C, Mege N, Ulring K, Seyfert-Margolis V, Conway M, Francisco D, Molzahn A, Erickson H, Wilson C, Schunk R, Sierra B, Hughes T, Smolen K, Desjardins M, van Haren S, Mitre X, Cauley J, Li X, Tong A, Evans B, Montesano C, Licona J, Krauss J, Chang J, Izaguirre N, Chaudhary O, Coppi A, Fournier J, Mohanty S, Muenker M, Nelson A, Raddassi K, Rainone M, Ruff W, Salahuddin S, Schulz W, Vijayakumar P, Wang H, Wunder E, Young H, Zhao Y, Saksena M, Altman D, Kojic E, Srivastava K, Eaker L, Bermúdez-González M, Beach K, Sominsky L, Azad A, Carreño J, Singh G, Raskin A, Tcheou J, Bielak D, Kawabata H, Mulder L, Kleiner G, Lee A, E, Fernandes A, Manohar M, Hagan T, Blish C, Din H, Roque J, Yang S, Brunton A, Sullivan P, Strnad M, Lyski Z, Coulter F, Booth J, Sinko L, Moldawer L, Borresen B, Roth-Manning B, Song L, Nelson E, Lewis-Smith M, Smith J, Tipan P, Siles N, Bazzi S, Geltman J, Hurley K, Gabriele G, Sieg S, Vaysman T, Bristow L, Hussaini L, Hellmeister K, Samaha H, Cheng A, Spainhour C, Scherer E, Johnson B, Bechnak A, Ciric C, Hewitt L, Carter E, Mcnair N, Panganiban B, Huerta C, Usher J, Ribeiro S, Altman M, Becker P, Rouphael N. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine 2022, 83: 104208. PMID: 35952496, PMCID: PMC9359694, DOI: 10.1016/j.ebiom.2022.104208.
- Basic principles of neuroimmunologyYoshida TM, Wang A, Hafler DA. Basic principles of neuroimmunology. Seminars In Immunopathology 2022, 44: 685-695. PMID: 35732977, DOI: 10.1007/s00281-022-00951-7.
- Fatty Acid Metabolism and T Cells in Multiple SclerosisPompura SL, Hafler DA, Dominguez-Villar M. Fatty Acid Metabolism and T Cells in Multiple Sclerosis. Frontiers In Immunology 2022, 13: 869197. PMID: 35603182, PMCID: PMC9116144, DOI: 10.3389/fimmu.2022.869197.
- Population genetics meets single-cell sequencingSumida TS, Hafler DA. Population genetics meets single-cell sequencing. Science 2022, 376: 134-135. PMID: 35389792, DOI: 10.1126/science.abq0426.
- Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping.Fan R, Liu Y, DiStasio M, Su G, Asashima H, Enninful A, Qin X, Deng Y, Bordignon P, Cassano M, Tomayko M, Xu M, Halene S, Craft J, Hafler D. Spatial-CITE-seq: spatially resolved high-plex protein and whole transcriptome co-mapping. Research Square 2022 PMID: 35378748, PMCID: PMC8978952, DOI: 10.21203/rs.3.rs-1499315/v1.
- Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cellsSumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nature Immunology 2022, 23: 632-642. PMID: 35301508, PMCID: PMC8989655, DOI: 10.1038/s41590-022-01152-y.
- Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brainMarsh SE, Walker AJ, Kamath T, Dissing-Olesen L, Hammond TR, de Soysa TY, Young AMH, Murphy S, Abdulraouf A, Nadaf N, Dufort C, Walker AC, Lucca LE, Kozareva V, Vanderburg C, Hong S, Bulstrode H, Hutchinson PJ, Gaffney DJ, Hafler DA, Franklin RJM, Macosko EZ, Stevens B. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nature Neuroscience 2022, 25: 306-316. PMID: 35260865, DOI: 10.1038/s41593-022-01022-8.
- TCR-sequencing in cancer and autoimmunity: barcodes and beyondPauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. TCR-sequencing in cancer and autoimmunity: barcodes and beyond. Trends In Immunology 2022, 43: 180-194. PMID: 35090787, PMCID: PMC8882139, DOI: 10.1016/j.it.2022.01.002.
- Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason L, Ko A, Montgomery R, Farhadian S, Iwasaki A, Shaw A, van Dijk D, Zhao H, Kleinstein S, Hafler D, Kaminski N, Dela Cruz C. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nature Communications 2022, 13: 440. PMID: 35064122, PMCID: PMC8782894, DOI: 10.1038/s41467-021-27716-4.
- Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia GravisNowak RJ, Coffey CS, Goldstein JM, Dimachkie MM, Benatar M, Kissel JT, Wolfe GI, Burns TM, Freimer ML, Nations S, Granit V, Smith AG, Richman DP, Ciafaloni E, Al-Lozi MT, Sams LA, Quan D, Ubogu E, Pearson B, Sharma A, Yankey JW, Uribe L, Shy M, Amato AA, Conwit R, O'Connor KC, Hafler DA, Cudkowicz ME, Barohn RJ. Phase 2 Trial of Rituximab in Acetylcholine Receptor Antibody-Positive Generalized Myasthenia Gravis. Neurology 2021, 98: e376-e389. PMID: 34857535, PMCID: PMC8793103, DOI: 10.1212/wnl.0000000000013121.
- The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunityKuchroo JR, Hafler DA, Sharpe AH, Lucca LE. The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity. Science Immunology 2021, 6: eabf4034. PMID: 34739340, DOI: 10.1126/sciimmunol.abf4034.
- 23Na imaging: Worth its salt for understanding multiple sclerosisLongbrake EE, Hafler DA. 23Na imaging: Worth its salt for understanding multiple sclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2110799118. PMID: 34376559, PMCID: PMC8379906, DOI: 10.1073/pnas.2110799118.
- Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study, , Rouphael N, Maecker H, Montgomery R, Diray-Arce J, Kleinstein S, Altman M, Bosinger S, Eckalbar W, Guan L, Hough C, Krammer F, Langelier C, Levy O, McEnaney K, Peters B, Rahman A, Rajan J, Sigelman S, Steen H, van Bakel H, Ward A, Wilson M, Woodruff P, Zamecnik C, Augustine A, Ozonoff A, Reed E, Becker P, Higuita N, Altman M, Atkinson M, Baden L, Becker P, Bime C, Brakenridge S, Calfee C, Cairns C, Corry D, Davis M, Augustine A, Ehrlich L, Haddad E, Erle D, Fernandez-Sesma A, Hafler D, Hough C, Kheradmand F, Kleinstein S, Kraft M, Levy O, McComsey G, Melamed E, Messer W, Metcalf J, Montgomery R, Nadeau K, Ozonoff A, Peters B, Pulendran B, Reed E, Rouphael N, Sarwal M, Schaenman J, Sekaly R, Shaw A, Simon V. Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study. Science Immunology 2021, 6: eabf3733. PMID: 34376480, PMCID: PMC8713959, DOI: 10.1126/sciimmunol.abf3733.
- Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cellsJiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells. JCI Insight 2021, 6: e148035. PMID: 34061047, PMCID: PMC8262471, DOI: 10.1172/jci.insight.148035.
- Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19. The Journal Of Immunology 2021, 206: 2785-2790. PMID: 34049971, PMCID: PMC8627528, DOI: 10.4049/jimmunol.2100135.
- Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Hafler D, Sumida T, Dulberg S, Schupp J, Stillwell H, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo V. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. Research Square 2021 PMID: 34127967, PMCID: PMC8202434, DOI: 10.21203/rs.3.rs-133494/v1.
- NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell dataHe L, Davila-Velderrain J, Sumida TS, Hafler DA, Kellis M, Kulminski AM. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications Biology 2021, 4: 629. PMID: 34040149, PMCID: PMC8155058, DOI: 10.1038/s42003-021-02146-6.
- A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO).Dumbrava E, Dougan M, Gupta S, Cappelli L, Katsumoto T, Rahma O, Painter J, Wang Y, Suarez-Almazor M, Reid P, Wesley S, Hafler D, Bingham C, Warner B, Chung L, Ott P, Kluger H, Khosroshahi A, Tawbi H, Sharon E. A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO). Journal Of Clinical Oncology 2021, 39: tps2676-tps2676. DOI: 10.1200/jco.2021.39.15_suppl.tps2676.
- Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression ProfilesZhao A, Unterman A, Schupp J, Adams T, Sumida T, Ryu C, DeIuliis G, Yan X, Hafler D, Dela Cruz C, Herzog E, Kaminski N. Comparative scRNA-seq Analysis of Peripheral Blood Mononuclear Cells from Patients with COVID-19 and Idiopathic Pulmonary Fibrosis Demonstrates Dissimilar Cell Shifts and Gene Expression Profiles. 2021, a4361-a4361. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4361.
- Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in childrenRamaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children. Immunity 2021, 54: 1083-1095.e7. PMID: 33891889, PMCID: PMC8043654, DOI: 10.1016/j.immuni.2021.04.003.
- Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity. MedRxiv : The Preprint Server For Health Sciences 2021 PMID: 33300011, PMCID: PMC7724682, DOI: 10.1101/2020.12.01.20241364.
- Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cellsLucca LE, Axisa PP, Lu B, Harnett B, Jessel S, Zhang L, Raddassi K, Zhang L, Olino K, Clune J, Singer M, Kluger HM, Hafler DA. Circulating clonally expanded T cells reflect functions of tumor-infiltrating T cells. Journal Of Experimental Medicine 2021, 218: e20200921. PMID: 33651881, PMCID: PMC7933991, DOI: 10.1084/jem.20200921.
- Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune CellsTran TT, Rane CK, Zito CR, Weiss SA, Jessel S, Lucca L, Lu BY, Oria VO, Adeniran A, Chiang VL, Omay SB, Hafler DA, Kluger HM, Jilaveanu LB. Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells. Cancers 2021, 13: 1049. PMID: 33801444, PMCID: PMC7958624, DOI: 10.3390/cancers13051049.
- Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosisPompura SL, Wagner A, Kitz A, Laperche J, Yosef N, Dominguez-Villar M, Hafler D. Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis. Journal Of Clinical Investigation 2021, 131 PMID: 33170805, PMCID: PMC7810477, DOI: 10.1172/jci138519.
- Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells.Sumida TS, Dulberg S, Schupp J, Stillwell HA, Axisa PP, Comi M, Lincoln M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells. BioRxiv : The Preprint Server For Biology 2020 PMID: 33140047, PMCID: PMC7605554, DOI: 10.1101/2020.10.30.362947.
- Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-AmericansNakatsuka N, Patterson N, Patsopoulos NA, Altemose N, Tandon A, Beecham AH, McCauley JL, Isobe N, Hauser S, De Jager PL, Hafler DA, Oksenberg JR, Reich D. Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans. Scientific Reports 2020, 10: 16902. PMID: 33037294, PMCID: PMC7547691, DOI: 10.1038/s41598-020-74035-7.
- Epigenetic fine-mapping: identification of causal mechanisms for autoimmunityLincoln MR, Axisa PP, Hafler DA. Epigenetic fine-mapping: identification of causal mechanisms for autoimmunity. Current Opinion In Immunology 2020, 67: 50-56. PMID: 32977183, DOI: 10.1016/j.coi.2020.09.002.
- Transcriptomic and clonal characterization of T cells in the human central nervous systemPappalardo JL, Zhang L, Pecsok MK, Perlman K, Zografou C, Raddassi K, Abulaban A, Krishnaswamy S, Antel J, van Dijk D, Hafler DA. Transcriptomic and clonal characterization of T cells in the human central nervous system. Science Immunology 2020, 5 PMID: 32948672, PMCID: PMC8567322, DOI: 10.1126/sciimmunol.abb8786.
- Abstract CT249: A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO)Ileana Dumbrava E, Suarez-Almazor M, Painter J, Johanns T, Dougan M, Cappelli L, Wang Y, Bingham C, Gupta S, Warner B, Rahma O, Naidoo J, Ott P, Hafler D, Kluger H, Khosroshahi A, Naqash R, Chung L, Katsumoto T, Kummar S, Tawbi H, Sharon E. Abstract CT249: A phase 1b study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO). Cancer Research 2020, 80: ct249-ct249. DOI: 10.1158/1538-7445.am2020-ct249.
- A phase Ib study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO).Ileana Dumbrava E, Suarez-Almazor M, Painter J, Johanns T, Dougan M, Cappelli L, Bingham C, Wang Y, Gupta S, Warner B, Rahma O, Naidoo J, Ott P, Hafler D, Kluger H, Khosroshahi A, Katsumoto T, Kummar S, Sharon E, Tawbi H. A phase Ib study of nivolumab in patients with autoimmune disorders and advanced malignancies (AIM-NIVO). Journal Of Clinical Oncology 2020, 38: tps3158-tps3158. DOI: 10.1200/jco.2020.38.15_suppl.tps3158.
- Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MSLucca LE, Lerner BA, Park C, DeBartolo D, Harnett B, Kumar VP, Ponath G, Raddassi K, Huttner A, Hafler DA, Pitt D. Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e712. PMID: 32269065, PMCID: PMC7188477, DOI: 10.1212/nxi.0000000000000712.
- Disease state prediction from single-cell data using graph attention networksRavindra N, Sehanobish A, Pappalardo J, Hafler D, van Dijk D. Disease state prediction from single-cell data using graph attention networks. 2020, 121-130. DOI: 10.1145/3368555.3384449.
- Chapter 51 Multiple SclerosisWesley S, Hafler D. Chapter 51 Multiple Sclerosis. 2020, 961-986. DOI: 10.1016/b978-0-12-812102-3.00051-8.
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis RiskConsortium I, Mitrovič M, Patsopoulos N, Beecham A, Dankowski T, Goris A, Dubois B, D’hooghe M, Lemmens R, Van Damme P, Søndergaard H, Sellebjerg F, Sorensen P, Ullum H, Thørner L, Werge T, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusik S, Gourraud P, Andlauer T, Pongratz V, Buck D, Gasperi C, Bayas A, Heesen C, Kümpfel T, Linker R, Paul F, Stangel M, Tackenberg B, Bergh F, Warnke C, Wiendl H, Wildemann B, Zettl U, Ziemann U, Tumani H, Gold R, Grummel V, Hemmer B, Knier B, Lill C, Luessi F, Dardiotis E, Agliardi C, Barizzone N, Mascia E, Bernardinelli L, Comi G, Cusi D, Esposito F, Ferrè L, Comi C, Galimberti D, Leone M, Sorosina M, Mescheriakova J, Hintzen R, van Duijn C, Teunissen C, Bos S, Myhr K, Celius E, Lie B, Spurkland A, Comabella M, Montalban X, Alfredsson L, Stridh P, Hillert J, Jagodic M, Piehl F, Jelčić I, Martin R, Sospedra M, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Neville M, Santaniello A, Caillier S, Calabresi P, Cree B, Cross A, Davis M, Haines J, de Bakker P, Delgado S, Dembele M, Edwards K, Fitzgerald K, Hakonarson H, Konidari I, Lathi E, Manrique C, Pericak-Vance M, Piccio L, Schaefer C, McCabe C, Weiner H, Goldstein J, Olsson T, Hadjigeorgiou G, Taylor B, Tajouri L, Charlesworth J, Booth D, Harbo H, Ivinson A, Hauser S, Compston A, Stewart G, Zipp F, Barcellos L, Baranzini S, Martinelli-Boneschi F, D’Alfonso S, Ziegler A, Oturai A, McCauley J, Sawcer S, Oksenberg J, De Jager P, Kockum I, Hafler D, Cotsapas C. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell 2020, 180: 403. PMID: 31978348, PMCID: PMC6978797, DOI: 10.1016/j.cell.2020.01.002.
- CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiomeChoileáin SN, Kleinewietfeld M, Raddassi K, Hafler DA, Ruff WE, Longbrake EE. CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome. Journal Of Translational Autoimmunity 2019, 3: 100032. PMID: 32743517, PMCID: PMC7388357, DOI: 10.1016/j.jtauto.2019.100032.
- Siponimod Chips Away at Progressive MSLongbrake EE, Hafler DA. Siponimod Chips Away at Progressive MS. Cell 2019, 179: 1440. PMID: 31951523, PMCID: PMC8023412, DOI: 10.1016/j.cell.2019.11.034.
- Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibilityPatsopoulos N, Baranzini S, Santaniello A, Shoostari P, Cotsapas C, Wong G, Beecham A, James T, Replogle J, Vlachos I, McCabe C, Pers T, Brandes A, White C, Keenan B, Cimpean M, Winn P, Panteliadis I, Robbins A, Andlauer T, Zarzycki O, Dubois B, Goris A, Søndergaard H, Sellebjerg F, Sorensen P, Ullum H, Thørner L, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusic S, Berthele A, Pongratz V, Buck D, Gasperi C, Graetz C, Grummel V, Hemmer B, Hoshi M, Knier B, Korn T, Lill C, Luessi F, Mühlau M, Zipp F, Dardiotis E, Agliardi C, Amoroso A, Barizzone N, Benedetti M, Bernardinelli L, Cavalla P, Clarelli F, Comi G, Cusi D, Esposito F, Ferrè L, Galimberti D, Guaschino C, Leone M, Martinelli V, Moiola L, Salvetti M, Sorosina M, Vecchio D, Zauli A, Santoro S, Mancini N, Zuccalà M, Mescheriakova J, van Duijn C, Bos S, Celius E, Spurkland A, Comabella M, Montalban X, Alfredsson L, Bomfim I, Gomez-Cabrero D, Hillert J, Jagodic M, Lindén M, Piehl F, Jelčić I, Martin R, Sospedra M, Baker A, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Molyneux P, Neville M, Thorpe J, Bradshaw E, Caillier S, Calabresi P, Cree B, Cross A, Davis M, de Bakker P, Delgado S, Dembele M, Edwards K, Fitzgerald K, Frohlich I, Gourraud P, Haines J, Hakonarson H, Kimbrough D, Isobe N, Konidari I, Lathi E, Lee M, Li T, An D, Zimmer A, Madireddy L, Manrique C, Mitrovic M, Olah M, Patrick E, Pericak-Vance M, Piccio L, Schaefer C, Weiner H, Lage K, Compston A, Hafler D, Harbo H, Hauser S, Stewart G, D’Alfonso S, Hadjigeorgiou G, Taylor B, Barcellos L, Booth D, Hintzen R, Kockum I, Martinelli-Boneschi F, McCauley J, Oksenberg J, Oturai A, Sawcer S, Ivinson A, Olsson T, De Jager P. Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science 2019, 365 PMID: 31604244, PMCID: PMC7241648, DOI: 10.1126/science.aav7188.
- Immunotherapeutic Approaches for Multiple Sclerosis*Eisenbarth G, Weiner H, Hafler D. Immunotherapeutic Approaches for Multiple Sclerosis*. 2019, 173-188. DOI: 10.1201/9781351073448-14.
- AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune diseaseKitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease. EMBO Reports 2019, 20: e48624. PMID: 31379130, PMCID: PMC6680151, DOI: 10.15252/embr.201948624.
- Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunitySumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology 2019, 20: 943-943. PMID: 31175348, DOI: 10.1038/s41590-019-0438-6.
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis RiskConsortium I, Mitrovič M, Patsopoulos N, Beecham A, Dankowski T, Goris A, Dubois B, D’hooghe M, Lemmens R, Van Damme P, Søndergaard H, Sellebjerg F, Sorensen P, Ullum H, Thørner L, Werge T, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusik S, Gourraud P, Andlauer T, Pongratz V, Buck D, Gasperi C, Bayas A, Heesen C, Kümpfel T, Linker R, Paul F, Stangel M, Tackenberg B, Bergh F, Warnke C, Wiendl H, Wildemann B, Zettl U, Ziemann U, Tumani H, Gold R, Grummel V, Hemmer B, Knier B, Lill C, Luessi F, Dardiotis E, Agliardi C, Barizzone N, Mascia E, Bernardinelli L, Comi G, Cusi D, Esposito F, Ferrè L, Comi C, Galimberti D, Leone M, Sorosina M, Mescheriakova J, Hintzen R, van Duijn C, Theunissen C, Bos S, Myhr K, Celius E, Lie B, Spurkland A, Comabella M, Montalban X, Alfredsson L, Stridh P, Hillert J, Jagodic M, Piehl F, Jelčić I, Martin R, Sospedra M, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Neville M, Santaniello A, Caillier S, Calabresi P, Cree B, Cross A, Davis M, Haines J, de Bakker P, Delgado S, Dembele M, Edwards K, Fitzgerald K, Hakonarson H, Konidari I, Lathi E, Manrique C, Pericak-Vance M, Piccio L, Schaefer C, McCabe C, Weiner H, Goldstein J, Olsson T, Hadjigeorgiou G, Taylor B, Tajouri L, Charlesworth J, Booth D, Harbo H, Ivinson A, Hauser S, Compston A, Stewart G, Zipp F, Barcellos L, Baranzini S, Martinelli-Boneschi F, D’Alfonso S, Ziegler A, Oturai A, McCauley J, Sawcer S, Oksenberg J, De Jager P, Kockum I, Hafler D, Cotsapas C. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell 2019, 178: 262. PMID: 31251915, PMCID: PMC6602362, DOI: 10.1016/j.cell.2019.06.016.
- Corrigendum to “Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo” [Yjaut 96C (2019) 40–49]Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Corrigendum to “Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo” [Yjaut 96C (2019) 40–49]. Journal Of Autoimmunity 2019, 102: 179. PMID: 31109655, DOI: 10.1016/j.jaut.2019.05.008.
- Autoantibodies against Neurologic Antigens in Nonneurologic AutoimmunityStathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O’Connor K. Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. The Journal Of Immunology 2019, 202: ji1801295. PMID: 30824481, PMCID: PMC6452031, DOI: 10.4049/jimmunol.1801295.
- Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patientsJames JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner J, Guthridge JM, Norris JM, Holers VM. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. EBioMedicine 2019, 42: 76-85. PMID: 30952617, PMCID: PMC6491794, DOI: 10.1016/j.ebiom.2019.03.063.
- Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of miceUraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology 2019, 4: 948-955. PMID: 30858571, PMCID: PMC6533137, DOI: 10.1038/s41564-019-0385-x.
- From Big Data to Precision MedicineHulsen T, Jamuar SS, Moody AR, Karnes JH, Varga O, Hedensted S, Spreafico R, Hafler DA, McKinney EF. From Big Data to Precision Medicine. Frontiers In Medicine 2019, 6: 34. PMID: 30881956, PMCID: PMC6405506, DOI: 10.3389/fmed.2019.00034.
- Multiple sclerosis enters a grey areaPappalardo JL, Hafler DA. Multiple sclerosis enters a grey area. Nature 2019, 566: 465-466. PMID: 30809050, DOI: 10.1038/d41586-019-00563-6.
- TIGIT signaling restores suppressor function of Th1 TregsLucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA. TIGIT signaling restores suppressor function of Th1 Tregs. JCI Insight 2019, 4: e124427. PMID: 30728325, PMCID: PMC6413794, DOI: 10.1172/jci.insight.124427.
- CHAPTER 2 Genetics of Multiple SclerosisAbulaban A, Hafler D, Longbrake E. CHAPTER 2 Genetics of Multiple Sclerosis. 2019, 33-54. DOI: 10.1039/9781788016070-00033.
- Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosisPonath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D. Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis. Nature Communications 2018, 9: 5337. PMID: 30559390, PMCID: PMC6297228, DOI: 10.1038/s41467-018-07785-8.
- Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratchetingMurray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D. Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. Lab On A Chip 2018, 18: 3703. PMID: 30420988, DOI: 10.1039/c8lc90095g.
- Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunitySumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA. Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity. Nature Immunology 2018, 19: 1391-1402. PMID: 30374130, PMCID: PMC6240373, DOI: 10.1038/s41590-018-0236-6.
- Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis RiskConsortium I, Mitrovič M, Patsopoulos N, Beecham A, Dankowski T, Goris A, Dubois B, D’hooghe M, Lemmens R, Van Damme P, Søndergaard H, Sellebjerg F, Sorensen P, Ullum H, Thørner L, Werge T, Saarela J, Cournu-Rebeix I, Damotte V, Fontaine B, Guillot-Noel L, Lathrop M, Vukusik S, Gourraud P, Andlauer T, Pongratz V, Buck D, Gasperi C, Bayas A, Heesen C, Kümpfel T, Linker R, Paul F, Stangel M, Tackenberg B, Bergh F, Warnke C, Wiendl H, Wildemann B, Zettl U, Ziemann U, Tumani H, Gold R, Grummel V, Hemmer B, Knier B, Lill C, Luessi F, Dardiotis E, Agliardi C, Barizzone N, Mascia E, Bernardinelli L, Comi G, Cusi D, Esposito F, Ferrè L, Comi C, Galimberti D, Leone M, Sorosina M, Mescheriakova J, Hintzen R, van Duijn C, Theunissen C, Bos S, Myhr K, Celius E, Lie B, Spurkland A, Comabella M, Montalban X, Alfredsson L, Stridh P, Hillert J, Jagodic M, Piehl F, Jelčić I, Martin R, Sospedra M, Ban M, Hawkins C, Hysi P, Kalra S, Karpe F, Khadake J, Lachance G, Neville M, Santaniello A, Caillier S, Calabresi P, Cree B, Cross A, Davis M, Haines J, de Bakker P, Delgado S, Dembele M, Edwards K, Fitzgerald K, Hakonarson H, Konidari I, Lathi E, Manrique C, Pericak-Vance M, Piccio L, Schaefer C, McCabe C, Weiner H, Goldstein J, Olsson T, Hadjigeorgiou G, Taylor B, Tajouri L, Charlesworth J, Booth D, Harbo H, Ivinson A, Hauser S, Compston A, Stewart G, Zipp F, Barcellos L, Baranzini S, Martinelli-Boneschi F, D’Alfonso S, Ziegler A, Oturai A, McCauley J, Sawcer S, Oksenberg J, De Jager P, Kockum I, Hafler D, Cotsapas C. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell 2018, 175: 1679-1687.e7. PMID: 30343897, PMCID: PMC6269166, DOI: 10.1016/j.cell.2018.09.049.
- Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIVFarhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.
- Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivoDominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA. Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo. Journal Of Autoimmunity 2018, 96: 40-49. PMID: 30122421, PMCID: PMC7882197, DOI: 10.1016/j.jaut.2018.08.002.
- Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratchetingMurray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Rhaddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D. Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting. Lab On A Chip 2018, 18: 2396-2409. PMID: 30039125, PMCID: PMC6095198, DOI: 10.1039/c8lc00518d.
- Regulatory T cells in autoimmune diseaseDominguez-Villar M, Hafler DA. Regulatory T cells in autoimmune disease. Nature Immunology 2018, 19: 665-673. PMID: 29925983, PMCID: PMC7882196, DOI: 10.1038/s41590-018-0120-4.
- Regulatory T Cells: From Discovery to AutoimmunityKitz A, Singer E, Hafler D. Regulatory T Cells: From Discovery to Autoimmunity. Cold Spring Harbor Perspectives In Medicine 2018, 8: a029041. PMID: 29311129, PMCID: PMC6280708, DOI: 10.1101/cshperspect.a029041.
- Chapter 46 Multiple sclerosisCotsapas C, Mitrovic M, Hafler D. Chapter 46 Multiple sclerosis. 2018, 148: 723-730. PMID: 29478610, DOI: 10.1016/b978-0-444-64076-5.00046-6.
- Podoplanin is a negative regulator of Th17 inflammationNylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA. Podoplanin is a negative regulator of Th17 inflammation. JCI Insight 2017, 2: e92321. PMID: 28878118, PMCID: PMC5621890, DOI: 10.1172/jci.insight.92321.
- Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiformeGoods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC. Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme. PLOS ONE 2017, 12: e0181538. PMID: 28880903, PMCID: PMC5589094, DOI: 10.1371/journal.pone.0181538.
- Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responsesAvey S, Cheung F, Fermin D, Frelinger J, Gaujoux R, Gottardo R, Khatri P, Kleinstein S, Kotliarov Y, Meng H, Sauteraud R, Shen-Orr S, Tsang J, Vallania F, Anguiano E, Baisch J, Baldwin N, Belshe R, Blevins T, Chaussabel D, Davis M, Fikrig E, Grill D, Hafler D, Henrich E, Joshi S, Kaech S, Kennedy R, Mohanty S, Montgomery R, Oberg A, Obermoser G, Ovsyannikova I, Palucka A, Pascual V, Poland G, Pulendran B, Reinherz E, Shaw A, Siconolfi B, Stuart K, Tsang S, Ueda I, Wilson J, Zapata H. Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses. Science Immunology 2017, 2 PMID: 28842433, PMCID: PMC5800877, DOI: 10.1126/sciimmunol.aal4656.
- Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitmentLucca LE, Hafler DA. Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment. Journal Of Clinical Investigation 2017, 127: 1218-1220. PMID: 28319049, PMCID: PMC5373854, DOI: 10.1172/jci93565.
- Co‐inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastomaLucca LE, Hafler DA. Co‐inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma. Immunological Reviews 2017, 276: 9-25. PMID: 28258696, PMCID: PMC5338636, DOI: 10.1111/imr.12529.
- Abstract 213: Hematoma-infiltrating Macrophages Transition From Inflammatory to Reparative Programs in Patients After Intracerebral HemorrhageAskenase M, Goods B, Steinschneider A, Raddassi K, Beatty H, Hafler D, Love J, Sansing L. Abstract 213: Hematoma-infiltrating Macrophages Transition From Inflammatory to Reparative Programs in Patients After Intracerebral Hemorrhage. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.213.
- Solving Immunology?Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC. Solving Immunology? Trends In Immunology 2016, 38: 116-127. PMID: 27986392, PMCID: PMC5695553, DOI: 10.1016/j.it.2016.11.006.
- TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhageTaylor RA, Chang CF, Goods BA, Hammond MD, Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH. TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage. Journal Of Clinical Investigation 2016, 127: 280-292. PMID: 27893460, PMCID: PMC5199690, DOI: 10.1172/jci88647.
- The Human Functional Genomics Project: Understanding Generation of DiversityPappalardo JL, Hafler DA. The Human Functional Genomics Project: Understanding Generation of Diversity. Cell 2016, 167: 894-896. PMID: 27814519, DOI: 10.1016/j.cell.2016.10.040.
- NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis RiskConsortium T, Antel J, Ban M, Baranzini S, Barcellos L, Barizzone N, Beecham A, Berge T, Bernardinelli L, Booth D, Bos S, Buck D, Butkiewicz M, Celius E, Comabella M, Compston A, Dedham K, Cotsapas C, Alfonso S, De Jager P, Dubois B, Duquette P, Fontaine B, Gasperi C, Gil E, Goris A, Gourraud P, Graetz C, Gyllenberg A, Hadjigeorgiou G, Hafler D, Hribko D, Haines J, Harbo H, Hauser S, Warto S, Hawkins C, Hemmer B, Henry R, Hintzen R, Horakova D, Ivinson A, Howard M, Jelcic I, Kaskow B, Kira J, Kleinova P, Kockum I, Kucerova K, Lill C, Luessi F, Malhotra S, Martin R, Martinelli F, Matsushita T, McCabe C, McCauley J, Mescheriakkova J, Mitrovic M, Moen S, Montalban X, Muhlau M, Nakmura Y, Oksenberg J, Olsson T, Oturai A, Palotie A, Patsopoulos N, Pavlicova J, Pericak-Vance P, Piehl F, Rebeix I, Rioux J, Saarela J, Sawcer S, Sellebjerg F, Sondergaard H, Sorensen P, Sospedra M, Spurkland A, Stewart G, Taylor B, Uitterlinden A, Van Duijn C, Zipp F. NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk. Neuron 2016, 92: 333-335. PMID: 27764667, PMCID: PMC5641967, DOI: 10.1016/j.neuron.2016.09.052.
- Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy GrailLongbrake EE, Hafler DA. Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail. JAMA Neurology 2016, 73: 777-8. PMID: 27244583, PMCID: PMC5198230, DOI: 10.1001/jamaneurol.2016.1227.
- National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and SicknessOh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG. National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness. Hypertension 2016, 68: 281-288. PMID: 27324228, PMCID: PMC4945367, DOI: 10.1161/hypertensionaha.116.07415.
- AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune diseaseKitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M. AKT isoforms modulate Th1‐like Treg generation and function in human autoimmune disease. EMBO Reports 2016, 17: 1169-1183. PMID: 27312110, PMCID: PMC4967959, DOI: 10.15252/embr.201541905.
- Multiple sclerosisAxisa PP, Hafler DA. Multiple sclerosis. Current Opinion In Neurology 2016, 29: 345-353. PMID: 27058221, PMCID: PMC7882195, DOI: 10.1097/wco.0000000000000319.
- Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T CellsArterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. The Journal Of Immunology 2016, 196: 4040-4051. PMID: 27183637, PMCID: PMC4874532, DOI: 10.4049/jimmunol.1502276.
- PD-1 marks dysfunctional regulatory T cells in malignant gliomasLowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight 2016, 1: e85935. PMID: 27182555, PMCID: PMC4864991, DOI: 10.1172/jci.insight.85935.
- Evaluation of KIR4.1 as an Immune Target in Multiple SclerosisChastre A, Hafler DA, O'Connor KC. Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. New England Journal Of Medicine 2016, 374: 1495-1496. PMID: 27074083, PMCID: PMC4918464, DOI: 10.1056/nejmc1513302.
- Power estimation for non-standardized multisite studiesKeshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Consortium I, Hauser SL, Oksenberg JR, Henry RG. Power estimation for non-standardized multisite studies. NeuroImage 2016, 134: 281-294. PMID: 27039700, PMCID: PMC5656257, DOI: 10.1016/j.neuroimage.2016.03.051.
- CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatmentCao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D. CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment. Neurology 2016, 86: 1553-1556. PMID: 26984943, PMCID: PMC5573201, DOI: 10.1212/wnl.0000000000002594.
- The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA. The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations. Current Drug Targets 2016, 17: 651-65. PMID: 26844569, DOI: 10.2174/1389450117666160201105934.
- Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived ImmunoglobulinsWillis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O’Connor K. Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins. Frontiers In Immunology 2015, 6: 600. PMID: 26648933, PMCID: PMC4663633, DOI: 10.3389/fimmu.2015.00600.
- CBM-06IMMUNE BIOMARKER RESULTS FROM A TRIAL OF NIVOLUMAB ± IPILIMUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: CHECKMATE-143Lowther D, Weinhold K, Reap E, Vlahovic G, Omuro A, Sahebjam S, Baehring J, Voloschin A, Cloughesy T, Lim M, Coric V, Latek R, Simon J, Lerner B, Raddassi K, Hafler D, Sampson J. CBM-06IMMUNE BIOMARKER RESULTS FROM A TRIAL OF NIVOLUMAB ± IPILIMUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: CHECKMATE-143. Neuro-Oncology 2015, 17: v70-v70. PMCID: PMC4638710, DOI: 10.1093/neuonc/nov211.06.
- IMCT-03SAFETY AND ACTIVITY OF NIVOLUMAB MONOTHERAPY AND NIVOLUMAB IN COMBINATION WITH IPILIMUMAB IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS FROM CHECKMATE-143Sampson J, Omuro A, Vlahovic G, Sahebjam S, Baehring J, Hafler D, Voloschin A, Simon J, Latek R, Coric V, Cloughesy T, Lim M, Reardon D. IMCT-03SAFETY AND ACTIVITY OF NIVOLUMAB MONOTHERAPY AND NIVOLUMAB IN COMBINATION WITH IPILIMUMAB IN RECURRENT GLIOBLASTOMA: UPDATED RESULTS FROM CHECKMATE-143. Neuro-Oncology 2015, 17: v107-v107. PMCID: PMC4638899, DOI: 10.1093/neuonc/nov218.03.
- CBM-04PD-1 EXPRESSION IDENTIFIES EXHAUSTED TUMOR INFILTRATING REGULATORY T CELLS IN GLIOBLASTOMALucca L, Goods B, Lowther D, Hernandez A, Lerner B, Gunel M, Raddassi K, Simon J, Latek R, Coric V, Love J, Hafler D. CBM-04PD-1 EXPRESSION IDENTIFIES EXHAUSTED TUMOR INFILTRATING REGULATORY T CELLS IN GLIOBLASTOMA. Neuro-Oncology 2015, 17: v69-v70. PMCID: PMC4638708, DOI: 10.1093/neuonc/nov211.04.
- CBM-05FUNCTIONAL DIFFERENCES BETWEEN PD-1+ AND PD-1– CD4+ T EFFECTOR CELLS IN HEALTHY DONORS AND PATIENTS WITH GLIOBLASTOMAGoods B, Lowther D, Lucca L, Hernandez A, Lerner B, Gunel M, Raddassi K, Simon J, Coric V, Love J, Hafler D. CBM-05FUNCTIONAL DIFFERENCES BETWEEN PD-1+ AND PD-1– CD4+ T EFFECTOR CELLS IN HEALTHY DONORS AND PATIENTS WITH GLIOBLASTOMA. Neuro-Oncology 2015, 17: v70-v70. PMCID: PMC4638709, DOI: 10.1093/neuonc/nov211.05.
- Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cellsHernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. Journal Of Clinical Investigation 2015, 125: 4212-4222. PMID: 26524592, PMCID: PMC4639983, DOI: 10.1172/jci81151.
- Prospects of immune checkpoint modulators in the treatment of glioblastomaPreusser M, Lim M, Hafler DA, Reardon DA, Sampson JH. Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nature Reviews Neurology 2015, 11: 504-514. PMID: 26260659, PMCID: PMC4782584, DOI: 10.1038/nrneurol.2015.139.
- Sodium-activated macrophages: the salt mine expandsLucca LE, Hafler DA. Sodium-activated macrophages: the salt mine expands. Cell Research 2015, 25: 885-886. PMID: 26215700, PMCID: PMC4528060, DOI: 10.1038/cr.2015.91.
- Biomarkers in multiple sclerosisHousley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology 2015, 161: 51-58. PMID: 26143623, DOI: 10.1016/j.clim.2015.06.015.
- Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuliHousley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA. Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli. Science Translational Medicine 2015, 7: 291ra93. PMID: 26062845, PMCID: PMC4574294, DOI: 10.1126/scitranslmed.aaa9223.
- Genetic basis of autoimmunityMarson A, Housley WJ, Hafler DA. Genetic basis of autoimmunity. Journal Of Clinical Investigation 2015, 125: 2234-2241. PMID: 26030227, PMCID: PMC4497748, DOI: 10.1172/jci78086.
- Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143.Sampson J, Vlahovic G, Sahebjam S, Omuro A, Baehring J, Hafler D, Voloschin A, Paliwal P, Grosso J, Coric V, Cloughesy T, Lim M, Reardon D. Preliminary safety and activity of nivolumab and its combination with ipilimumab in recurrent glioblastoma (GBM): CHECKMATE-143. Journal Of Clinical Oncology 2015, 33: 3010-3010. DOI: 10.1200/jco.2015.33.15_suppl.3010.
- Editorial: T Cell Regulation by the EnvironmentHafler DA, Astier AL. Editorial: T Cell Regulation by the Environment. Frontiers In Immunology 2015, 6: 229. PMID: 26029214, PMCID: PMC4429623, DOI: 10.3389/fimmu.2015.00229.
- Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosisCao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Science Translational Medicine 2015, 7: 287ra74. PMID: 25972006, PMCID: PMC4497538, DOI: 10.1126/scitranslmed.aaa8038.
- Thymic Selection: To Thine Own Self Be TrueKitz A, Hafler DA. Thymic Selection: To Thine Own Self Be True. Immunity 2015, 42: 788-789. PMID: 25992854, DOI: 10.1016/j.immuni.2015.05.007.
- Erratum: Multiple sclerosis—a quiet revolutionRansohoff RM, Hafler DA, Lucchinetti CF. Erratum: Multiple sclerosis—a quiet revolution. Nature Reviews Neurology 2015, 11: 246-246. PMID: 25799926, DOI: 10.1038/nrneurol.2015.49.
- Integrative analysis of 111 reference human epigenomesKundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller M, Amin V, Whitaker J, Schultz M, Ward L, Sarkar A, Quon G, Sandstrom R, Eaton M, Wu Y, Pfenning A, Wang X, ClaussnitzerYaping Liu M, Coarfa C, Alan Harris R, Shoresh N, Epstein C, Gjoneska E, Leung D, Xie W, David Hawkins R, Lister R, Hong C, Gascard P, Mungall A, Moore R, Chuah E, Tam A, Canfield T, Scott Hansen R, Kaul R, Sabo P, Bansal M, Carles A, Dixon J, Farh K, Feizi S, Karlic R, Kim A, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer T, Neph S, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari R, Siebenthall K, Sinnott-Armstrong N, Stevens M, Thurman R, Wu J, Zhang B, Zhou X, Abdennur N, Adli M, Akerman M, Barrera L, Antosiewicz-Bourget J, Ballinger T, Barnes M, Bates D, Bell R, Bennett D, Bianco K, Bock C, Boyle P, Brinchmann J, Caballero-Campo P, Camahort R, Carrasco-Alfonso M, Charnecki T, Chen H, Chen Z, Cheng J, Cho S, Chu A, Chung W, Cowan C, Athena Deng Q, Deshpande V, Diegel M, Ding B, Durham T, Echipare L, Edsall L, Flowers D, Genbacev-Krtolica O, Gifford C, Gillespie S, Giste E, Glass I, Gnirke A, Gormley M, Gu H, Gu J, Hafler D, Hangauer M, Hariharan M, Hatan M, Haugen E, He Y, Heimfeld S, Herlofsen S, Hou Z, Humbert R, Issner R, Jackson A, Jia H, Jiang P, Johnson A, Kadlecek T, Kamoh B, Kapidzic M, Kent J, Kim A, Kleinewietfeld M, Klugman S, Krishnan J, Kuan S, Kutyavin T, Lee A, Lee K, Li J, Li N, Li Y, Ligon K, Lin S, Lin Y, Liu J, Liu Y, Luckey C, Ma Y, Maire C, Marson A, Mattick J, Mayo M, McMaster M, Metsky H, Mikkelsen T, Miller D, Miri M, Mukame E, Nagarajan R, Neri F, Nery J, Nguyen T, O’Geen H, Paithankar S, Papayannopoulou T, Pelizzola M, Plettner P, Propson N, Raghuraman S, Raney B, Raubitschek A, Reynolds A, Richards H, Riehle K, Rinaudo P, Robinson J, Rockweiler N, Rosen E, Rynes E, Schein J, Sears R, Sejnowski T, Shafer A, Shen L, Shoemaker R, Sigaroudinia M, Slukvin I, Stehling-Sun S, Stewart R, Subramanian S, Suknuntha K, Swanson S, Tian S, Tilden H, Tsai L, Urich M, Vaughn I, Vierstra J, Vong S, Wagner U, Wang H, Wang T, Wang Y, Weiss A, Whitton H, Wildberg A, Witt H, Won K, Xie M, Xing X, Xu I, Xuan Z, Ye Z, Yen C, Yu P, Zhang X, Zhang X, Zhao J, Zhou Y, Zhu J, Zhu Y, Ziegler S, Beaudet A, Boyer L, De Jager P, Farnham P, Fisher S, Haussler D, Jones S, Li W, Marra M, McManus M, Sunyaev S, Thomson J, Tlsty T, Tsai L, Wang W, Waterland R, Zhang M, Chadwick L, Bernstein B, Costello J, Ecker J, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos J, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature 2015, 518: 317-330. PMID: 25693563, PMCID: PMC4530010, DOI: 10.1038/nature14248.
- Multiple sclerosis—a quiet revolutionRansohoff RM, Hafler DA, Lucchinetti CF. Multiple sclerosis—a quiet revolution. Nature Reviews Neurology 2015, 11: 134-142. PMID: 25686758, PMCID: PMC4556342, DOI: 10.1038/nrneurol.2015.14.
- Monoallelic expression of the human FOXP2 speech geneAdegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Monoallelic expression of the human FOXP2 speech gene. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 112: 6848-6854. PMID: 25422445, PMCID: PMC4460484, DOI: 10.1073/pnas.1411270111.
- TLR7 induces anergy in human CD4+ T cellsDominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA. TLR7 induces anergy in human CD4+ T cells. Nature Immunology 2014, 16: 118-128. PMID: 25401424, PMCID: PMC4413902, DOI: 10.1038/ni.3036.
- Prolonged Proinflammatory Cytokine Production in Monocytes Modulated by Interleukin 10 After Influenza Vaccination in Older AdultsMohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC. Prolonged Proinflammatory Cytokine Production in Monocytes Modulated by Interleukin 10 After Influenza Vaccination in Older Adults. The Journal Of Infectious Diseases 2014, 211: 1174-1184. PMID: 25367297, PMCID: PMC4366602, DOI: 10.1093/infdis/jiu573.
- Systems Immunology Reveals Markers of Susceptibility to West Nile Virus InfectionQian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR. Systems Immunology Reveals Markers of Susceptibility to West Nile Virus Infection. MSphere 2014, 22: 6-16. PMID: 25355795, PMCID: PMC4278927, DOI: 10.1128/cvi.00508-14.
- Genetic and epigenetic fine mapping of causal autoimmune disease variantsFarh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 2014, 518: 337-343. PMID: 25363779, PMCID: PMC4336207, DOI: 10.1038/nature13835.
- B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodesStern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine 2014, 6: 248ra107. PMID: 25100741, PMCID: PMC4388137, DOI: 10.1126/scitranslmed.3008879.
- Microbial Reprogramming Inhibits Western Diet-Associated ObesityOlds W, Poutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian B, Ibrahim Y, Lakritz J, Kearney S, Chatzigiagkos A, Hafler D, Alm E, Erdman S. Microbial Reprogramming Inhibits Western Diet-Associated Obesity. 2014, 17-43. DOI: 10.1201/b17254-6.
- Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric DataPyne S, Lee SX, Wang K, Irish J, Tamayo P, Nazaire MD, Duong T, Ng SK, Hafler D, Levy R, Nolan GP, Mesirov J, McLachlan GJ. Joint Modeling and Registration of Cell Populations in Cohorts of High-Dimensional Flow Cytometric Data. PLOS ONE 2014, 9: e100334. PMID: 24983991, PMCID: PMC4077578, DOI: 10.1371/journal.pone.0100334.
- Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis.Ekong U, Hill M, Edmunds C, Han G, Bhela S, Hafler D, Kleinewietfeld M. Identification of Pathogenic IL-17 Producing FOXP3+ Tregs in Patients With De Novo Autoimmune Hepatitis. Transplantation 2014, 98: 872-873. DOI: 10.1097/00007890-201407151-02977.
- Enhanced suppressor function of TIM‐3+FoxP3+ regulatory T cellsGautron A, Dominguez-Villar M, de Marcken M, Hafler DA. Enhanced suppressor function of TIM‐3+FoxP3+ regulatory T cells. European Journal Of Immunology 2014, 44: 2703-2711. PMID: 24838857, PMCID: PMC4165702, DOI: 10.1002/eji.201344392.
- SP0104 The Molecular Basis of Autoimmune DiseaseHafler D. SP0104 The Molecular Basis of Autoimmune Disease. Annals Of The Rheumatic Diseases 2014, 73: 27. DOI: 10.1136/annrheumdis-2014-eular.6254.
- Randomized phase IIb study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) alone or in combination with ipilimumab versus bevacizumab in patients (pts) with recurrent glioblastoma (GBM).Sampson J, Vlahovic G, Desjardins A, Friedman H, Baehring J, Hafler D, Rollin L, Coric V, Perez S, Reardon D. Randomized phase IIb study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) alone or in combination with ipilimumab versus bevacizumab in patients (pts) with recurrent glioblastoma (GBM). Journal Of Clinical Oncology 2014, 32: tps2101-tps2101. DOI: 10.1200/jco.2014.32.15_suppl.tps2101.
- Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cellsKofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA. Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. Journal Of Clinical Investigation 2014, 124: 2513-2522. PMID: 24812667, PMCID: PMC4089462, DOI: 10.1172/jci72973.
- Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in LeukocytesRaj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T, Lee M, Asinovski N, Frohlich I, Imboywa S, Von Korff A, Okada Y, Patsopoulos NA, Davis S, McCabe C, Paik HI, Srivastava GP, Raychaudhuri S, Hafler DA, Koller D, Regev A, Hacohen N, Mathis D, Benoist C, Stranger BE, De Jager PL. Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes. Science 2014, 344: 519-523. PMID: 24786080, PMCID: PMC4910825, DOI: 10.1126/science.1249547.
- TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cellsLiu B, Cao Y, Huizinga TW, Hafler DA, Toes RE. TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells. European Journal Of Immunology 2014, 44: 2121-2129. PMID: 24737107, DOI: 10.1002/eji.201344341.
- Regulatory T cells in autoimmune neuroinflammationKleinewietfeld M, Hafler DA. Regulatory T cells in autoimmune neuroinflammation. Immunological Reviews 2014, 259: 231-244. PMID: 24712469, PMCID: PMC3990868, DOI: 10.1111/imr.12169.
- Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell ResponsesJoller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, Kuchroo VK. Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses. Immunity 2014, 40: 569-581. PMID: 24745333, PMCID: PMC4070748, DOI: 10.1016/j.immuni.2014.02.012.
- Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent MechanismsXiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms. Immunity 2014, 40: 477-489. PMID: 24745332, PMCID: PMC4066874, DOI: 10.1016/j.immuni.2014.04.004.
- pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoiresVander Heiden JA, Yaari G, Uduman M, Stern JN, O'Connor KC, Hafler DA, Vigneault F, Kleinstein SH. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics 2014, 30: 1930-1932. PMID: 24618469, PMCID: PMC4071206, DOI: 10.1093/bioinformatics/btu138.
- Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic CellsLee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N. Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells. Science 2014, 343: 1246980. PMID: 24604203, PMCID: PMC4124741, DOI: 10.1126/science.1246980.
- Chapter 52 Multiple SclerosisHernandez A, O’Connor K, Hafler D. Chapter 52 Multiple Sclerosis. 2014, 735-756. DOI: 10.1016/b978-0-12-384929-8.00052-6.
- Multiple Sclerosis and Acute Disseminated Encephalomyelitis: ImmunologyBailey M, Hafler D, Pelletier D. Multiple Sclerosis and Acute Disseminated Encephalomyelitis: Immunology. 2014, 144-147. DOI: 10.1016/b978-0-12-385157-4.00186-x.
- Role of “Western Diet” in Inflammatory Autoimmune DiseasesManzel A, Muller DN, Hafler DA, Erdman SE, Linker RA, Kleinewietfeld M. Role of “Western Diet” in Inflammatory Autoimmune Diseases. Current Allergy And Asthma Reports 2013, 14: 404. PMID: 24338487, PMCID: PMC4034518, DOI: 10.1007/s11882-013-0404-6.
- Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA EffectsPatsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, , , Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects. PLOS Genetics 2013, 9: e1003926. PMID: 24278027, PMCID: PMC3836799, DOI: 10.1371/journal.pgen.1003926.
- The plasticity of human Treg and Th17 cells and its role in autoimmunityKleinewietfeld M, Hafler DA. The plasticity of human Treg and Th17 cells and its role in autoimmunity. Seminars In Immunology 2013, 25: 305-312. PMID: 24211039, PMCID: PMC3905679, DOI: 10.1016/j.smim.2013.10.009.
- Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locusOttoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL. Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology 2013, 81: 1891-1899. PMID: 24174586, PMCID: PMC3843384, DOI: 10.1212/01.wnl.0000436612.66328.8a.
- The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in HumansLozano E, Joller N, Cao Y, Kuchroo VK, Hafler DA. The CD226/CD155 Interaction Regulates the Proinflammatory (Th1/Th17)/Anti-Inflammatory (Th2) Balance in Humans. The Journal Of Immunology 2013, 191: 3673-3680. PMID: 23980210, PMCID: PMC3819731, DOI: 10.4049/jimmunol.1300945.
- Regulatory T Cells in MSGawlik B, Hafler D. Regulatory T Cells in MS. 2013, 27-47. DOI: 10.1007/978-1-4614-7953-6_2.
- Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosisQuerol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81: 956-963. PMID: 23921886, PMCID: PMC3888197, DOI: 10.1212/wnl.0b013e3182a43b48.
- Microbial Reprogramming Inhibits Western Diet-Associated ObesityPoutahidis T, Kleinewietfeld M, Smillie C, Levkovich T, Perrotta A, Bhela S, Varian BJ, Ibrahim YM, Lakritz JR, Kearney SM, Chatzigiagkos A, Hafler DA, Alm EJ, Erdman SE. Microbial Reprogramming Inhibits Western Diet-Associated Obesity. PLOS ONE 2013, 8: e68596. PMID: 23874682, PMCID: PMC3707834, DOI: 10.1371/journal.pone.0068596.
- Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 ControlsConsortium I, Baranzini S, Khankhanian P, Patsopoulos N, Li M, Stankovich J, Cotsapas C, Søndergaard H, Ban M, Barizzone N, Bergamaschi L, Booth D, Buck D, Cavalla P, Celius E, Comabella M, Comi G, Compston A, Cournu-Rebeix I, D’alfonso S, Damotte V, Din L, Dubois B, Elovaara I, Esposito F, Fontaine B, Franke A, Goris A, Gourraud P, Graetz C, Guerini F, Guillot-Noel L, Hafler D, Hakonarson H, Hall P, Hamsten A, Harbo H, Hemmer B, Hillert J, Kemppinen A, Kockum I, Koivisto K, Larsson M, Lathrop M, Leone M, Lill C, Macciardi F, Martin R, Martinelli V, Martinelli-Boneschi F, McCauley J, Myhr K, Naldi P, Olsson T, Oturai A, Pericak-Vance M, Perla F, Reunanen M, Saarela J, Saker-Delye S, Salvetti M, Sellebjerg F, Sørensen P, Spurkland A, Stewart G, Taylor B, Tienari P, Winkelmann J, Consortium W, Zipp F, Ivinson A, Haines J, Sawcer S, DeJager P, Hauser S, Oksenberg J. Network-Based Multiple Sclerosis Pathway Analysis with GWAS Data from 15,000 Cases and 30,000 Controls. American Journal Of Human Genetics 2013, 92: 854-865. PMID: 23731539, PMCID: PMC3958952, DOI: 10.1016/j.ajhg.2013.04.019.
- Specific peripheral B cell tolerance defects in patients with multiple sclerosisKinnunen T, Chamberlain N, Morbach H, Cantaert T, Lynch M, Preston-Hurlburt P, Herold KC, Hafler DA, O’Connor K, Meffre E. Specific peripheral B cell tolerance defects in patients with multiple sclerosis. Journal Of Clinical Investigation 2013, 123: 2737-2741. PMID: 23676463, PMCID: PMC3668812, DOI: 10.1172/jci68775.
- FlowCAP: comparison of automated and manual gating of standardized lyoplate flow cytometry data (P3374)Scheuermann R, Finak G, Ramey J, Taghiyar J, Stanton R, Brandes A, De Jager P, Qiu P, McCoy J, Hafler D, Maecker H, Mosmann T, Brinkman R, Gottardo R. FlowCAP: comparison of automated and manual gating of standardized lyoplate flow cytometry data (P3374). The Journal Of Immunology 2013, 190: 135.13-135.13. DOI: 10.4049/jimmunol.190.supp.135.13.
- Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing– remitting multiple sclerosisVan Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O’Connor K, Hafler DA, Steinman L, Robinson WH. Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing– remitting multiple sclerosis. Multiple Sclerosis Journal 2013, 19: 1726-1733. PMID: 23612879, PMCID: PMC4411183, DOI: 10.1177/1352458513485653.
- PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritisLarman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. Journal Of Autoimmunity 2013, 43: 1-9. PMID: 23497938, PMCID: PMC3677742, DOI: 10.1016/j.jaut.2013.01.013.
- Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cellsKleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker RA, Muller DN, Hafler DA. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature 2013, 496: 518-522. PMID: 23467095, PMCID: PMC3746493, DOI: 10.1038/nature11868.
- Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing DataYaari G, Heiden J, Uduman M, Gadala-Maria D, Gupta N, Stern JN, O’Connor K, Hafler DA, Laserson U, Vigneault F, Kleinstein SH. Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data. Frontiers In Immunology 2013, 4: 358. PMID: 24298272, PMCID: PMC3828525, DOI: 10.3389/fimmu.2013.00358.
- Immune-mediated disease genetics: the shared basis of pathogenesisCotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends In Immunology 2012, 34: 22-26. PMID: 23031829, DOI: 10.1016/j.it.2012.09.001.
- An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease ActivityOttoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA Profile Identifies Two Subsets of Multiple Sclerosis Patients Differing in Disease Activity. Science Translational Medicine 2012, 4: 153ra131. PMID: 23019656, PMCID: PMC3753678, DOI: 10.1126/scitranslmed.3004186.
- Induction and molecular signature of pathogenic TH17 cellsLee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nature Immunology 2012, 13: 991-999. PMID: 22961052, PMCID: PMC3459594, DOI: 10.1038/ni.2416.
- Abstract 456: High Salt Induces Pathogenic Th17 Cells and Exacerbates Autoimmune DiseasesKleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R, Hafler D, Muller D. Abstract 456: High Salt Induces Pathogenic Th17 Cells and Exacerbates Autoimmune Diseases. Hypertension 2012, 60 DOI: 10.1161/hyp.60.suppl_1.a456.
- Correction: The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+T Cell ProliferationKofler D, Severson C, Mousissian N, De Jager P, Hafler D. Correction: The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+T Cell Proliferation. The Journal Of Immunology 2012, 189: 2063-2063. DOI: 10.4049/jimmunol.1290044.
- Erratum: Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonb therapy in multiple sclerosisVosslamber S, van der Voort L, van den Elskamp I, Heijmans R, Aubin C, Uitdehaag B, Crusius J, van der Pouw Kraan T, Comabella M, Montalban X, Hafler D, De Jager P, Killestein J, Polman C, Verweij C. Erratum: Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonb therapy in multiple sclerosis. Genes & Immunity 2012, 13: 443-443. DOI: 10.1038/gene.2012.18.
- Regulatory T cells in the central nervous systemLowther DE, Hafler DA. Regulatory T cells in the central nervous system. Immunological Reviews 2012, 248: 156-169. PMID: 22725960, DOI: 10.1111/j.1600-065x.2012.01130.x.
- Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 ExpressionKickler K, Maltby K, Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL. Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression. The Journal Of Immunology 2012, 188: 5303-5310. PMID: 22544928, PMCID: PMC3758685, DOI: 10.4049/jimmunol.1103090.
- Prostaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8)Astier A, Kickler K, Ni Choileain S, Stephen J, Hafler D, Jabbour H. Prostaglandin E2 affects T cell responses through modulation of CD46 expression. (178.8). The Journal Of Immunology 2012, 188: 178.8-178.8. DOI: 10.4049/jimmunol.188.supp.178.8.
- High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13)Kleinewietfeld M, Manzel A, Wu C, Titze J, Kuchroo V, Linker R, Muller D, Hafler D. High salt induces pathogenic Th17 cells and exacerbates autoimmune diseases (60.13). The Journal Of Immunology 2012, 188: 60.13-60.13. DOI: 10.4049/jimmunol.188.supp.60.13.
- The TIGIT/CD226 Axis Regulates Human T Cell FunctionLozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. The TIGIT/CD226 Axis Regulates Human T Cell Function. The Journal Of Immunology 2012, 188: 3869-3875. PMID: 22427644, PMCID: PMC3324669, DOI: 10.4049/jimmunol.1103627.
- Perspective: Deconstructing a diseaseHafler DA. Perspective: Deconstructing a disease. Nature 2012, 484: s6-s6. PMID: 22509507, DOI: 10.1038/nature11100.
- Multiple sclerosisNylander A, Hafler DA. Multiple sclerosis. Journal Of Clinical Investigation 2012, 122: 1180-1188. PMID: 22466660, PMCID: PMC3314452, DOI: 10.1172/jci58649.
- Class II MHC Self-Antigen Presentation in Human B and T LymphocytesCostantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC Self-Antigen Presentation in Human B and T Lymphocytes. PLOS ONE 2012, 7: e29805. PMID: 22299025, PMCID: PMC3267721, DOI: 10.1371/journal.pone.0029805.
- Fingolimod for Multiple SclerosisPelletier D, Hafler DA. Fingolimod for Multiple Sclerosis. New England Journal Of Medicine 2012, 366: 339-347. PMID: 22276823, DOI: 10.1056/nejmct1101691.
- Unraveling the autoimmune translational research process layer by layerBlumberg RS, Dittel B, Hafler D, von Herrath M, Nestle FO. Unraveling the autoimmune translational research process layer by layer. Nature Medicine 2012, 18: 35-41. PMID: 22227670, PMCID: PMC4592149, DOI: 10.1038/nm.2632.
- Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility lociPatsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman C, Freedman M, Hartung H, Arnason B, Comi G, Cook S, Filippi M, Goodin D, Jeffery D, O'Connor P, Ebers G, Langdon D, Reder A, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth D, Broadley S, Brown M, Browning B, Browning S, Butzkueven H, Carroll W, Chapman C, Foote S, Griffiths L, Kermode A, Kilpatrick T, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard R, Pender M, Perreau V, Perera D, Rubio J, Scott R, Slee M, Stankovich J, Stewart G, Taylor B, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi F, Compston A, Haines J, Hauser S, McCauley J, Ivinson A, Oksenberg J, Pericak-Vance M, Sawcer S, De Jager P, Hafler D, de Bakker P. Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci. Annals Of Neurology 2011, 70: 897-912. PMID: 22190364, PMCID: PMC3247076, DOI: 10.1002/ana.22609.
- Polyfunctional responses by human T cells result from sequential release of cytokinesHan Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: 1607-1612. PMID: 22160692, PMCID: PMC3277116, DOI: 10.1073/pnas.1117194109.
- Genome-Wide Assessment for Genetic Variants Associated with Ventricular Dysfunction after Primary Coronary Artery Bypass Graft SurgeryFox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE. Genome-Wide Assessment for Genetic Variants Associated with Ventricular Dysfunction after Primary Coronary Artery Bypass Graft Surgery. PLOS ONE 2011, 6: e24593. PMID: 21980348, PMCID: PMC3184087, DOI: 10.1371/journal.pone.0024593.
- The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell ProliferationKofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA. The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation. The Journal Of Immunology 2011, 187: 3286-3291. PMID: 21849685, DOI: 10.4049/jimmunol.1100626.
- Pervasive Sharing of Genetic Effects in Autoimmune DiseaseCotsapas C, Voight BF, Rossin E, Lage K, Neale BM, Wallace C, Abecasis GR, Barrett JC, Behrens T, Cho J, De Jager PL, Elder JT, Graham RR, Gregersen P, Klareskog L, Siminovitch KA, van Heel DA, Wijmenga C, Worthington J, Todd JA, Hafler DA, Rich SS, Daly MJ, . Pervasive Sharing of Genetic Effects in Autoimmune Disease. PLOS Genetics 2011, 7: e1002254. PMID: 21852963, PMCID: PMC3154137, DOI: 10.1371/journal.pgen.1002254.
- Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple SclerosisRaddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis. The Journal Of Immunology 2011, 187: 1039-1046. PMID: 21653833, PMCID: PMC3131477, DOI: 10.4049/jimmunol.1001543.
- Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complexZuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, Ivinson A, Compston A, Hafler D, Hauser S, Sawcer S, Pericak-Vance M, Barcellos L, Mortlock D, Haines J. Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex. Human Molecular Genetics 2011, 20: 3517-3524. PMID: 21653641, PMCID: PMC3153306, DOI: 10.1093/hmg/ddr250.
- Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune diseaseDominguez-Villar M, Baecher-Allan CM, Hafler DA. Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease. Nature Medicine 2011, 17: 673-675. PMID: 21540856, PMCID: PMC3675886, DOI: 10.1038/nm.2389.
- Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosisVosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BM, Crusius JB, van der PouwKraan T, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, Verweij CL. Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferonβ therapy in multiple sclerosis. Genes & Immunity 2011, 12: 466-472. PMID: 21471993, DOI: 10.1038/gene.2011.18.
- An Innate Role for IL-17Dominguez-Villar M, Hafler DA. An Innate Role for IL-17. Science 2011, 332: 47-48. PMID: 21454778, DOI: 10.1126/science.1205311.
- CD2 Costimulation Reveals Defective Activity by Human CD4+CD25hi Regulatory Cells in Patients with Multiple SclerosisBaecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA. CD2 Costimulation Reveals Defective Activity by Human CD4+CD25hi Regulatory Cells in Patients with Multiple Sclerosis. The Journal Of Immunology 2011, 186: 3317-3326. PMID: 21300823, PMCID: PMC4467560, DOI: 10.4049/jimmunol.1002502.
- Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulinObermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal Of Neuroimmunology 2011, 233: 245-248. PMID: 21353315, PMCID: PMC3090654, DOI: 10.1016/j.jneuroim.2011.01.010.
- A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibilityBush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes & Immunity 2011, 12: 335-340. PMID: 21346779, PMCID: PMC3136581, DOI: 10.1038/gene.2011.3.
- Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association dataWang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Medicine 2011, 3: 3. PMID: 21244703, PMCID: PMC3092088, DOI: 10.1186/gm217.
- Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosisLovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O’Connor K, Hafler DA. Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis. Brain 2011, 134: 534-541. PMID: 21216828, PMCID: PMC3030766, DOI: 10.1093/brain/awq350.
- Population structure and HLA DRB1*1501 in the response of subjects with multiple sclerosis to first-line treatmentsGross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. Population structure and HLA DRB1*1501 in the response of subjects with multiple sclerosis to first-line treatments. Journal Of Neuroimmunology 2010, 233: 168-174. PMID: 21115201, DOI: 10.1016/j.jneuroim.2010.10.038.
- A model for harmonizing flow cytometry in clinical trials.Maecker HT, McCoy JP, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, Nestle FO, Peakman M, Villanova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH. A model for harmonizing flow cytometry in clinical trials. Nature Immunology 2010, 11: 975-8. PMID: 20959798, PMCID: PMC3400260, DOI: 10.1038/ni1110-975.
- Human regulatory T cells in autoimmune diseasesCvetanovich GL, Hafler DA. Human regulatory T cells in autoimmune diseases. Current Opinion In Immunology 2010, 22: 753-760. PMID: 20869862, PMCID: PMC2997859, DOI: 10.1016/j.coi.2010.08.012.
- Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokineKonry T, Dominguez-Villar M, Baecher-Allan C, Hafler DA, Yarmush ML. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosensors And Bioelectronics 2010, 26: 2707-2710. PMID: 20888750, PMCID: PMC3141325, DOI: 10.1016/j.bios.2010.09.006.
- A Randomized Controlled Double-Masked Trial of Albuterol Add-on Therapy in Patients With Multiple SclerosisKhoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A Randomized Controlled Double-Masked Trial of Albuterol Add-on Therapy in Patients With Multiple Sclerosis. JAMA Neurology 2010, 67: 1055-1061. PMID: 20837847, PMCID: PMC2954052, DOI: 10.1001/archneurol.2010.222.
- HLA B*44Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL. HLA B*44. Neurology 2010, 75: 634-640. PMID: 20713950, PMCID: PMC2931768, DOI: 10.1212/wnl.0b013e3181ed9c9c.
- Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individualsBriggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos L. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12 566 individuals. Human Molecular Genetics 2010, 19: 4286-4295. PMID: 20699326, PMCID: PMC2951862, DOI: 10.1093/hmg/ddq328.
- A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosisLigocki AJ, Lovato L, Xiang D, Guidry P, Scheuermann RH, Willis SN, Almendinger S, Racke MK, Frohman EM, Hafler DA, O'Connor KC, Monson NL. A unique antibody gene signature is prevalent in the central nervous system of patients with multiple sclerosis. Journal Of Neuroimmunology 2010, 226: 192-193. PMID: 20655601, PMCID: PMC2937103, DOI: 10.1016/j.jneuroim.2010.06.016.
- TGF-β Induces IL-9 Production from Human Th17 CellsBeriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-β Induces IL-9 Production from Human Th17 Cells. The Journal Of Immunology 2010, 185: 46-54. PMID: 20498357, PMCID: PMC2936106, DOI: 10.4049/jimmunol.1000356.
- A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL, , . A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01. PLOS ONE 2010, 5: e11296. PMID: 20593013, PMCID: PMC2892470, DOI: 10.1371/journal.pone.0011296.
- A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosisBan M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Sexton D, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines J, Compston A, Sawcer S. A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis. Genes & Immunity 2010, 11: 660-664. PMID: 20574445, PMCID: PMC2946966, DOI: 10.1038/gene.2010.36.
- FOXP3+ regulatory T cells in the human immune systemSakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nature Reviews Immunology 2010, 10: 490-500. PMID: 20559327, DOI: 10.1038/nri2785.
- Functionally defective germline variants of sialic acid acetylesterase in autoimmunitySurolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010, 466: 243-247. PMID: 20555325, PMCID: PMC2900412, DOI: 10.1038/nature09115.
- Variation Within DNA Repair Pathway Genes and Risk of Multiple SclerosisBriggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Variation Within DNA Repair Pathway Genes and Risk of Multiple Sclerosis. American Journal Of Epidemiology 2010, 172: 217-224. PMID: 20522537, PMCID: PMC3658128, DOI: 10.1093/aje/kwq086.
- Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics 2010, 42: 469-70; author reply 470-1. PMID: 20502484, PMCID: PMC3109873, DOI: 10.1038/ng0610-469.
- Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengravingHan Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab On A Chip 2010, 10: 1391-1400. PMID: 20376398, PMCID: PMC3128808, DOI: 10.1039/b926849a.
- IL-12 induces human CD4+CD45RA-CD25hiCD127low/neg regulatory T cells to secrete IFNγ and IL-10 and acquire a non-regulatory effector phenotype (138.9)Dominguez-Villar M, Hafler D, Baecher-Allan C. IL-12 induces human CD4+CD45RA-CD25hiCD127low/neg regulatory T cells to secrete IFNγ and IL-10 and acquire a non-regulatory effector phenotype (138.9). The Journal Of Immunology 2010, 184: 138.9-138.9. DOI: 10.4049/jimmunol.184.supp.138.9.
- CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosisBronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, Hauser S, Oksenberg J, Barcellos L. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Human Molecular Genetics 2010, 19: 2331-2340. PMID: 20211854, PMCID: PMC2865376, DOI: 10.1093/hmg/ddq101.
- Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 GeneJakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, Søndergaard HB, Harbo HF, Mero IL, Gabriel SB, Mirel DB, Hauser SL, Kappos L, Polman C, De Jager PL, Hafler DA, Daly MJ, Palotie A, Saarela J, Peltonen L. Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene. American Journal Of Human Genetics 2010, 86: 285-291. PMID: 20159113, PMCID: PMC2820168, DOI: 10.1016/j.ajhg.2010.01.017.
- Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibilityZuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, International Multiple Sclerosis Genetics Consortium, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, Haines JL. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Human Genetics 2010, 127: 525-535. PMID: 20112030, PMCID: PMC2854871, DOI: 10.1007/s00439-010-0789-4.
- Characterization of the Myelin Specific Autoantibodies in Acute Disseminated EncephalomyelitisAlmendinger S, Lovato L, Fukaura H, Hafler D, O'Connor K. Characterization of the Myelin Specific Autoantibodies in Acute Disseminated Encephalomyelitis. Clinical Immunology 2010, 135: s81. DOI: 10.1016/j.clim.2010.03.243.
- IL-12 Induces Human CD4+CD45RA-CD25hiCD127low/neg Regulatory T Cells to Secrete IFNγ and IL-10 and Acquire a Non-regulatory Effector PhenotypeDominguez-Villar M, Hafler D, Baecher-Allan C. IL-12 Induces Human CD4+CD45RA-CD25hiCD127low/neg Regulatory T Cells to Secrete IFNγ and IL-10 and Acquire a Non-regulatory Effector Phenotype. Clinical Immunology 2010, 135: s132-s133. DOI: 10.1016/j.clim.2010.03.400.
- IL-1 Receptor Expression on Human Regulatory T Cells and IL-1β's Role in Reducing SuppressionCvetanovich G, Bradshaw E, Beriou G, Mousissian N, Baecher-Allan C, Hafler D. IL-1 Receptor Expression on Human Regulatory T Cells and IL-1β's Role in Reducing Suppression. Clinical Immunology 2010, 135: s131. DOI: 10.1016/j.clim.2010.03.395.
- Altered Synapse Formation by Self-reactive T Cells from MS PatientsSchubert D, Gordo S, Vardhana S, Pyrdol J, Seth N, Raddassi K, Hafler D, Dustin M, Wucherpfennig K. Altered Synapse Formation by Self-reactive T Cells from MS Patients. Clinical Immunology 2010, 135: s75-s76. DOI: 10.1016/j.clim.2010.03.227.
- CONTRIBUTING AUTHORSZeid N, Ascherio A, Banwell B, Bates A, Ben-Hur T, Bowling A, Davis S, De Jager P, Dutta R, Edan G, Frohman E, Frohman T, Gold R, Hafler D, Jacob A, jelČiĆ I, Kaplin A, Kerr D, Kleinschnitz C, Kozubal D, Lemack G, Linker R, lucchinetti C, Marriott J, Martin R, Matiello M, Melzer N, Meuth S, Morrissey S, Munger K, O'Connor P, Amato M, Pirko I, Pittock S, Schröder A, Shah A, Trapp B, Trecker C, Venkateswaran S, Voskuhl R, Weinshenker B, Wiendl H, Wingerchuk D, Young N, Zipoli V. CONTRIBUTING AUTHORS. 2010, 35: xi-xvii. DOI: 10.1016/b978-1-4160-6068-0.00024-3.
- Monocytes from Patients with Type 1 Diabetes Have Increased Gene Expression of Pro-inflammatory Cytokines or IL-10Bradshaw E, Elyaman W, Raddassi K, Mousissian N, Greer A, Orban T, Gottlieb P, Kent S, Hafler D. Monocytes from Patients with Type 1 Diabetes Have Increased Gene Expression of Pro-inflammatory Cytokines or IL-10. Clinical Immunology 2010, 135: s19. DOI: 10.1016/j.clim.2010.03.061.
- Automated High-Dimensional Flow Cytometric Data AnalysisPyne S, Hu X, Wang K, Rossin E, Lin T, Maier L, Baecher-Allan C, McLachlan G, Tamayo P, Hafler D, De Jager P, Mesirov J. Automated High-Dimensional Flow Cytometric Data Analysis. 2010, 6044: 577-577. DOI: 10.1007/978-3-642-12683-3_41.
- Regulation of Immunological Tolerance and Autoimmunity by the Enzyme Sialic Acid Acetylesterase (SIAE)Surolia I, Pirnie S, Chellappa V, Annaiah C, Moya J, Bell D, Haider K, Taylor K, De Jager P, Behrens T, Hafler D, Sands B, Murali M, Gregersen P, Pillai S. Regulation of Immunological Tolerance and Autoimmunity by the Enzyme Sialic Acid Acetylesterase (SIAE). Clinical Immunology 2010, 135: s16. DOI: 10.1016/j.clim.2010.03.054.
- Dissecting the Functional Consequences of the Validated Multiple Sclerosis Susceptibility Allele in TNFRSF1AOttoboni L, Mousissian N, Castillo I, Hafler D, De Jager P. Dissecting the Functional Consequences of the Validated Multiple Sclerosis Susceptibility Allele in TNFRSF1A. Clinical Immunology 2010, 135: s117. DOI: 10.1016/j.clim.2010.03.351.
- Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse FormationGordo S, Schubert D, Vardhana S, Seth N, Pyrdol J, Raddassi K, Hafler D, Dustin M, Wucherpfennig K. Efficient Activation of Self-reactive T Cells from MS Patients with Altered Synapse Formation. Clinical Immunology 2010, 135: s8. DOI: 10.1016/j.clim.2010.03.031.
- The PhenoGenetic Project: A Living Biobank Enabling the Study of Human Genetic and Immunologic VariationCastillo I, Lui Q, Ottoboni L, Briskin R, Alter G, Hafler D, De Jager P. The PhenoGenetic Project: A Living Biobank Enabling the Study of Human Genetic and Immunologic Variation. Clinical Immunology 2010, 135: s118-s119. DOI: 10.1016/j.clim.2010.03.355.
- Interleukin-9 Secretion by Human Th17 Cells is Inducible by TGF-β and Proinflammatory Cytokines and is Increased in Autoimmune DiabetesBeriou G, Bradshaw E, Lozano E, Baecher-Allan C, Hafler D. Interleukin-9 Secretion by Human Th17 Cells is Inducible by TGF-β and Proinflammatory Cytokines and is Increased in Autoimmune Diabetes. Clinical Immunology 2010, 135: s29. DOI: 10.1016/j.clim.2010.03.089.
- Chapter 3 Uncovering the Genetic Architecture of Multiple SclerosisDe Jager P, Hafler D. Chapter 3 Uncovering the Genetic Architecture of Multiple Sclerosis. 2010, 35: 43-56. DOI: 10.1016/b978-1-4160-6068-0.00003-6.
- RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 LevelsAstier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N. RNA Interference Screen in Primary Human T Cells Reveals FLT3 as a Modulator of IL-10 Levels. The Journal Of Immunology 2009, 184: 685-693. PMID: 20018615, PMCID: PMC3746748, DOI: 10.4049/jimmunol.0902443.
- On-Chip Activation and Subsequent Detection of Individual Antigen-Specific T CellsSong Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-Chip Activation and Subsequent Detection of Individual Antigen-Specific T Cells. Analytical Chemistry 2009, 82: 473-477. PMID: 20000848, PMCID: PMC2828941, DOI: 10.1021/ac9024363.
- Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci, , McCauley J, Zuvich R, Beecham A, De Jager P, Konidari I, Whitehead P, Aubin C, Ban M, Pobywajlo S, Briskin R, Romano S, Aggarwal N, Piccio L, McArdle W, Strachan D, Evans D, Cross A, Cree B, Rioux J, Barcellos L, Ivinson A, Compston A, Hafler D, Hauser S, Oksenberg J, Sawcer S, Pericak-Vance M, Haines J. Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Human Molecular Genetics 2009, 19: 953-962. PMID: 20007504, PMCID: PMC2816610, DOI: 10.1093/hmg/ddp542.
- Evaluating the Intrinsic Cysteine Redox-Dependent States of the A-Chain of Human Insulin Using NMR Spectroscopy, Quantum Chemical Calculations, and Mass SpectrometrySharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the Intrinsic Cysteine Redox-Dependent States of the A-Chain of Human Insulin Using NMR Spectroscopy, Quantum Chemical Calculations, and Mass Spectrometry. The Journal Of Physical Chemistry B 2009, 114: 585-591. PMID: 19954153, PMCID: PMC2829747, DOI: 10.1021/jp908729h.
- Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseasesRioux J, Goyette P, Vyse T, Hammarström L, Fernando M, Green T, De Jager P, Foisy S, Wang J, de Bakker P, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler D, Pan-Hammarström Q, Matell R, Sawcer S, Compston A, Cree B, Mirel D, Daly M, Behrens T, Klareskog L, Gregersen P, Oksenberg J, Hauser S. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 18680-18685. PMID: 19846760, PMCID: PMC2773992, DOI: 10.1073/pnas.0909307106.
- Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T CellsLiu DV, Maier LM, Hafler DA, Wittrup KD. Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells. Journal Of Immunotherapy 2009, 32: 887-894. PMID: 19816193, PMCID: PMC4078882, DOI: 10.1097/cji.0b013e3181b528da.
- Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk scoreDe Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, the steering committees of the BENEFIT B, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler D, Karlson E. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. The Lancet Neurology 2009, 8: 1111-1119. PMID: 19879194, PMCID: PMC3099419, DOI: 10.1016/s1474-4422(09)70275-3.
- Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 CellsBradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells. The Journal Of Immunology 2009, 183: 4432-4439. PMID: 19748982, PMCID: PMC2770506, DOI: 10.4049/jimmunol.0900576.
- Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple SclerosisMcLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-Dependent B Cell Autoimmunity to a Myelin Surface Antigen in Pediatric Multiple Sclerosis. The Journal Of Immunology 2009, 183: 4067-4076. PMID: 19687098, PMCID: PMC2795331, DOI: 10.4049/jimmunol.0801888.
- TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokinesHastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European Journal Of Immunology 2009, 39: 2492-2501. PMID: 19676072, PMCID: PMC2759376, DOI: 10.1002/eji.200939274.
- Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brainWillis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O’Connor K. Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain 2009, 132: 3318-3328. PMID: 19638446, PMCID: PMC2792367, DOI: 10.1093/brain/awp200.
- De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of FallotGreenway SC, Pereira AC, Lin JC, DePalma SR, Israel SJ, Mesquita SM, Ergul E, Conta JH, Korn JM, McCarroll SA, Gorham JM, Gabriel S, Altshuler DM, de Lourdes Quintanilla-Dieck M, Artunduaga MA, Eavey RD, Plenge RM, Shadick NA, Weinblatt ME, De Jager PL, Hafler DA, Breitbart RE, Seidman JG, Seidman CE. De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot. Nature Genetics 2009, 41: 931-935. PMID: 19597493, PMCID: PMC2747103, DOI: 10.1038/ng.415.
- T-Cells in Multiple SclerosisSeverson C, Hafler DA. T-Cells in Multiple Sclerosis. 2009, 51: 1-24. PMID: 19582415, DOI: 10.1007/400_2009_12.
- T-Cells in Multiple SclerosisSeverson C, Hafler D. T-Cells in Multiple Sclerosis. 2009, 51: 75-98. DOI: 10.1007/400_2009_9012.
- Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T CellsCostantino CM, Ploegh HL, Hafler DA. Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells. The Journal Of Immunology 2009, 183: 945-952. PMID: 19553543, PMCID: PMC2752291, DOI: 10.4049/jimmunol.0900921.
- Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility lociDe Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini S, McCauley J, Pericak-Vance M, Haines J, Gibson R, Naeglin Y, Uitdehaag B, Matthews P, Kappos L, Polman C, McArdle W, Strachan D, Evans D, Cross A, Daly M, Compston A, Sawcer S, Weiner H, Hauser S, Hafler D, Oksenberg J. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature Genetics 2009, 41: 776-782. PMID: 19525953, PMCID: PMC2757648, DOI: 10.1038/ng.401.
- Automated high-dimensional flow cytometric data analysisPyne S, Hu X, Wang K, Rossin E, Lin TI, Maier LM, Baecher-Allan C, McLachlan GJ, Tamayo P, Hafler DA, De Jager PL, Mesirov JP. Automated high-dimensional flow cytometric data analysis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 8519-8524. PMID: 19443687, PMCID: PMC2682540, DOI: 10.1073/pnas.0903028106.
- Autoimmunity risk alleles in costimulation pathwaysMaier LM, Hafler DA. Autoimmunity risk alleles in costimulation pathways. Immunological Reviews 2009, 229: 322-336. PMID: 19426231, DOI: 10.1111/j.1600-065x.2009.00777.x.
- The role of the CD58 locus in multiple sclerosisDe Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 5264-5269. PMID: 19237575, PMCID: PMC2664005, DOI: 10.1073/pnas.0813310106.
- Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluidOwens GP, Bennett JL, Lassmann H, O'Connor KC, Ritchie AM, Shearer A, Lam C, Yu X, Birlea M, DuPree C, Williamson RA, Hafler DA, Burgoon MP, Gilden D. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid. Annals Of Neurology 2009, 65: 639-649. PMID: 19557869, PMCID: PMC2843543, DOI: 10.1002/ana.21641.
- Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factorBan M, Goris A, Lorentzen Å, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal Of Human Genetics 2009, 17: 1309-1313. PMID: 19293837, PMCID: PMC2782567, DOI: 10.1038/ejhg.2009.41.
- Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MSKallio SP, Jakkula E, Purcell S, Suvela M, Koivisto K, Tienari PJ, Elovaara I, Pirttilä T, Reunanen M, Bronnikov D, Viander M, Meri S, Hillert J, Lundmark F, Harbo HF, Lorentzen Å, De Jager PL, Daly MJ, Hafler DA, Palotie A, Peltonen L, Saarela J. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. Human Molecular Genetics 2009, 18: 1670-1683. PMID: 19221116, PMCID: PMC2667286, DOI: 10.1093/hmg/ddp073.
- Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune ResponsesMaier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA. Soluble IL-2RA Levels in Multiple Sclerosis Subjects and the Effect of Soluble IL-2RA on Immune Responses. The Journal Of Immunology 2009, 182: 1541-1547. PMID: 19155502, PMCID: PMC3992946, DOI: 10.4049/jimmunol.182.3.1541.
- IL-17–producing human peripheral regulatory T cells retain suppressive functionBeriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, Baecher-Allan C, Hafler DA. IL-17–producing human peripheral regulatory T cells retain suppressive function. Blood 2009, 113: 4240-4249. PMID: 19171879, PMCID: PMC2676084, DOI: 10.1182/blood-2008-10-183251.
- IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor ProductionMaier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, , De Jager PL, Wicker LS, Todd JA, Hafler DA. IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production. PLOS Genetics 2009, 5: e1000322. PMID: 19119414, PMCID: PMC2602853, DOI: 10.1371/journal.pgen.1000322.
- Infection-Triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations in a Component of the Nuclear Pore, RANBP2Neilson DE, Adams MD, Orr CM, Schelling DK, Eiben RM, Kerr DS, Anderson J, Bassuk AG, Bye AM, Childs AM, Clarke A, Crow YJ, Di Rocco M, Dohna-Schwake C, Dueckers G, Fasano AE, Gika AD, Gionnis D, Gorman MP, Grattan-Smith PJ, Hackenberg A, Kuster A, Lentschig MG, Lopez-Laso E, Marco EJ, Mastroyianni S, Perrier J, Schmitt-Mechelke T, Servidei S, Skardoutsou A, Uldall P, van der Knaap MS, Goglin KC, Tefft DL, Aubin C, de Jager P, Hafler D, Warman ML. Infection-Triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations in a Component of the Nuclear Pore, RANBP2. American Journal Of Human Genetics 2009, 84: 44-51. PMID: 19118815, PMCID: PMC2668029, DOI: 10.1016/j.ajhg.2008.12.009.
- OR.43. Comparative Analysis of B Cell Repertoires Among Lesions and Normal Appearing White Matter in the Multiple Sclerosis Central Nervous SystemLovato L, Almendinger S, Willis S, Rodig S, Hafler D, O'Connor K. OR.43. Comparative Analysis of B Cell Repertoires Among Lesions and Normal Appearing White Matter in the Multiple Sclerosis Central Nervous System. Clinical Immunology 2009, 131: s20-s21. DOI: 10.1016/j.clim.2009.03.055.
- F.89. Elucidating the Antigen Specificity of B Cells Present within the CNS Lesions of Patients with MSWillis S, Almendinger S, Lovato L, Hafler D, O'Connor K. F.89. Elucidating the Antigen Specificity of B Cells Present within the CNS Lesions of Patients with MS. Clinical Immunology 2009, 131: s117. DOI: 10.1016/j.clim.2009.03.346.
- OR.31. Human TIM-3 Regulates Th1 and Th17 CytokinesHastings W, Anderson D, Kuchroo V, Hafler D. OR.31. Human TIM-3 Regulates Th1 and Th17 Cytokines. Clinical Immunology 2009, 131: s15. DOI: 10.1016/j.clim.2009.03.038.
- S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T CellsCostantino C, Ploegh H, Hafler D. S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T Cells. Clinical Immunology 2009, 131: s168. DOI: 10.1016/j.clim.2009.03.498.
- OR.39. Enumeration and Phenotype of Autoreactive B Cells in Pancreatic Draining Lymph Nodes from Type 1 Diabetes SubjectsKent S, Bradshaw E, Han Q, Varadarajan N, Greer A, Love J, Hafler D. OR.39. Enumeration and Phenotype of Autoreactive B Cells in Pancreatic Draining Lymph Nodes from Type 1 Diabetes Subjects. Clinical Immunology 2009, 131: s19. DOI: 10.1016/j.clim.2009.03.051.
- F.108. DNA Methylation of the Human FoxP3 Locus Differs Significantly Between Functionally Distinct Subpopulations of CD4+CD25high Human Regulatory T CellsCvetanovich G, Ashley C, Hafler D, Baecher-Allan C. F.108. DNA Methylation of the Human FoxP3 Locus Differs Significantly Between Functionally Distinct Subpopulations of CD4+CD25high Human Regulatory T Cells. Clinical Immunology 2009, 131: s122. DOI: 10.1016/j.clim.2009.03.361.
- OR.4. Cellular Senescence in Terminally Differentiated Human CD4+CD25hi IL-7Rneg HLA-DR+Regulatory T CellsCostantino C, Beriou G, Ashley C, Hafler D, Baecher-Allan C. OR.4. Cellular Senescence in Terminally Differentiated Human CD4+CD25hi IL-7Rneg HLA-DR+Regulatory T Cells. Clinical Immunology 2009, 131: s6-s7. DOI: 10.1016/j.clim.2009.03.011.
- F.27. Meta-analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility LociDe Jager P, de Bakker P, Wang J, Ottoboni L, Consortium I, Hauser S, Oksenberg J, Hafler D. F.27. Meta-analysis of Genome Scans and Replication Identify CD6, ICSBP1, and TNFRSF1A as Novel Multiple Sclerosis Susceptibility Loci. Clinical Immunology 2009, 131: s101. DOI: 10.1016/j.clim.2009.03.294.
- S.67. Detection of Myelin Reactive CD4+Cells in the Peripheral Blood of Patients with Multiple Sclerosis using MHC Class II TetramersRaddassi K, Yang J, Kent S, Bradshaw E, Bourcier K, Seyfert-Margolis V, Kwok W, Hafler D. S.67. Detection of Myelin Reactive CD4+Cells in the Peripheral Blood of Patients with Multiple Sclerosis using MHC Class II Tetramers. Clinical Immunology 2009, 131: s150-s151. DOI: 10.1016/j.clim.2009.03.444.
- S.119. CD127 and HLA DR Define Functionally Distinct Human Tregs- One Subsets Exhibits Decreased Activity in Multiple SclerosisAshley C, Hafler D, Baecher-Allan C. S.119. CD127 and HLA DR Define Functionally Distinct Human Tregs- One Subsets Exhibits Decreased Activity in Multiple Sclerosis. Clinical Immunology 2009, 131: s164-s165. DOI: 10.1016/j.clim.2009.03.487.
- T.22. Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Pro-inflammatory Cytokines Inducing Th17 CellsBradshaw E, Raddassi K, Elyaman W, Orban T, Gottlieb P, Kent S, Hafler D. T.22. Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Pro-inflammatory Cytokines Inducing Th17 Cells. Clinical Immunology 2009, 131: s57. DOI: 10.1016/j.clim.2009.03.163.
- OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T CellsBeriou G, Costantino C, Baecher-Allan C, Hafler D. OR.55. Transforming Growth Factor-beta is Crucial for the Differentiation and Regulation of Interleukin 9-producing Human CD4+T Cells. Clinical Immunology 2009, 131: s24. DOI: 10.1016/j.clim.2009.03.067.
- TIMs: central regulators of immune responsesHafler D, Kuchroo V. TIMs: central regulators of immune responses. Journal Of Cell Biology 2008, 183: i12-i12. DOI: 10.1083/jcb1835oia12.
- Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell LinesChoy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D. Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines. PLOS Genetics 2008, 4: e1000287. PMID: 19043577, PMCID: PMC2583954, DOI: 10.1371/journal.pgen.1000287.
- TIMs: central regulators of immune responsesHafler DA, Kuchroo V. TIMs: central regulators of immune responses. Journal Of Experimental Medicine 2008, 205: 2699-2701. PMID: 19015312, PMCID: PMC2585854, DOI: 10.1084/jem.20082429.
- Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodiesBradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies. Clinical Immunology 2008, 129: 10-18. PMID: 18675591, PMCID: PMC2577144, DOI: 10.1016/j.clim.2008.06.009.
- CTLA4Ig treatment in patients with multiple sclerosisViglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis. Neurology 2008, 71: 917-924. PMID: 18794494, DOI: 10.1212/01.wnl.0000325915.00112.61.
- Multiple Sclerosis and Regulatory T CellsCostantino CM, Baecher-Allan C, Hafler DA. Multiple Sclerosis and Regulatory T Cells. Journal Of Clinical Immunology 2008, 28: 697-706. PMID: 18763026, PMCID: PMC2752287, DOI: 10.1007/s10875-008-9236-x.
- SY-23 Human CD4+CD25high natural Tregs and Th17 effector cells are relatedBaecher-Allan C, Beriou G, Yang L, Hastings W, Anderson D, Kuchroo V, Hafler D. SY-23 Human CD4+CD25high natural Tregs and Th17 effector cells are related. Cytokine 2008, 43: 305. DOI: 10.1016/j.cyto.2008.07.340.
- Multiple Sclerosis and Regulatory T CellsHutton J, Baecher-Allan C, Hafler D. Multiple Sclerosis and Regulatory T Cells. 2008, 265-277. DOI: 10.1007/978-0-387-77909-6_13.
- Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological LossSmith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss. Transplantation 2008, 86: 54-62. PMID: 18622278, DOI: 10.1097/tp.0b013e318173a5da.
- IL-21 and TGF-β are required for differentiation of human TH17 cellsYang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK, Hafler DA. IL-21 and TGF-β are required for differentiation of human TH17 cells. Nature 2008, 454: 350-352. PMID: 18469800, PMCID: PMC2760130, DOI: 10.1038/nature07021.
- Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cellsDe Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O’Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain 2008, 131: 1701-1711. PMID: 18567923, PMCID: PMC2730047, DOI: 10.1093/brain/awn118.
- Human regulatory T cells and autoimmunityCostantino CM, Baecher‐Allan C, Hafler DA. Human regulatory T cells and autoimmunity. European Journal Of Immunology 2008, 38: 921-924. PMID: 18395861, PMCID: PMC2752283, DOI: 10.1002/eji.200738104.
- Lack of TIM-3 Immunoregulation in Multiple SclerosisYang L, Anderson DE, Kuchroo J, Hafler DA. Lack of TIM-3 Immunoregulation in Multiple Sclerosis. The Journal Of Immunology 2008, 180: 4409-4414. PMID: 18354161, DOI: 10.4049/jimmunol.180.7.4409.
- TIM-4 Expressed on APCs Induces T Cell Expansion and SurvivalRodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 Expressed on APCs Induces T Cell Expansion and Survival. The Journal Of Immunology 2008, 180: 4706-4713. PMID: 18354194, PMCID: PMC2948965, DOI: 10.4049/jimmunol.180.7.4706.
- Response to Comment on “MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells”Baecher-Allan C, Hafler D. Response to Comment on “MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells”. The Journal Of Immunology 2008, 180: 3626-3626. DOI: 10.4049/jimmunol.180.6.3626.
- Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain DegradationCostantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal Cysteine and Aspartic Proteases Are Heterogeneously Expressed and Act Redundantly to Initiate Human Invariant Chain Degradation. The Journal Of Immunology 2008, 180: 2876-2885. PMID: 18292509, DOI: 10.4049/jimmunol.180.5.2876.
- Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosisVaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. Journal Of Neuroimmunology 2008, 195: 140-145. PMID: 18403025, PMCID: PMC2702859, DOI: 10.1016/j.jneuroim.2008.01.002.
- Integrating risk factorsDe Jager PL, Simon KC, Munger KL, Rioux JD, Hafler DA, Ascherio A. Integrating risk factors. Neurology 2008, 70: 1113-1118. PMID: 18272866, DOI: 10.1212/01.wnl.0000294325.63006.f8.
- The developing mosaic of autoimmune disease riskMaier LM, Hafler DA. The developing mosaic of autoimmune disease risk. Nature Genetics 2008, 40: 131-132. PMID: 18227869, DOI: 10.1038/ng0208-131.
- F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MSMcLaughlin K, Chitnis T, Banwell B, Bar-Or A, Kuhle J, Kappos L, Rostasy K, Pohl D, Wong S, Tavakoli N, Tenembaum S, Franz B, O'Connor K, Hafler D, Wucherpfennig K. F.14. Autoantibodies to Myelin Oligodendrocyte Glycoprotein in Pediatric MS. Clinical Immunology 2008, 127: s47-s48. DOI: 10.1016/j.clim.2008.03.126.
- Sa.102. Discovery and Characterization of Novel Human TIM-3 Splice VariantsHastings W, Anderson D, Kuchroo V, Hafler D. Sa.102. Discovery and Characterization of Novel Human TIM-3 Splice Variants. Clinical Immunology 2008, 127: s114. DOI: 10.1016/j.clim.2008.03.323.
- OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 CellsAnderson D, Yang L, Baecher-Allan C, Bettelli E, Oukka M, Kuchroo V, Hafler D. OR.41. IL-21 and TGF-β are Required for Differentiation of Human Th17 Cells. Clinical Immunology 2008, 127: s18-s19. DOI: 10.1016/j.clim.2008.03.047.
- Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi LibraryAstier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. Flt3, a New Regulator of IL-10 Production by Human T Cells, Identified Using an RNAi Library. Clinical Immunology 2008, 127: s29. DOI: 10.1016/j.clim.2008.03.074.
- OR.102. The CD58 Pathway is Implicated in MS SusceptibilityDe Jager P, Baecher-Allan C, Maier L, Sawcer S, Goris A, Saarela J, Barcellos L, Dubois B, Peltonen L, Palotie A, Weiner H, Booth D, Stewart G, Pericak-Vance M, Haines J, Rioux J, Hauser S, Daly M, Waliszewska A, Oksenberg J, Hafler D. OR.102. The CD58 Pathway is Implicated in MS Susceptibility. Clinical Immunology 2008, 127: s40-s41. DOI: 10.1016/j.clim.2008.03.109.
- Sa.77. Ex Vivo Activated State of Type 1 Diabetic MonocytesBradshaw E, Kent S, Greer A, Elyaman W, Raddassi K, Love J, Orban T, Hafler D. Sa.77. Ex Vivo Activated State of Type 1 Diabetic Monocytes. Clinical Immunology 2008, 127: s106. DOI: 10.1016/j.clim.2008.03.298.
- OR.39. Differentiation of Natural Human CD4+CD25high Tregs to Th17 Effector CellsBeriou G, Ashley C, Constantino C, Hafler D, Baecher-Allan C. OR.39. Differentiation of Natural Human CD4+CD25high Tregs to Th17 Effector Cells. Clinical Immunology 2008, 127: s18. DOI: 10.1016/j.clim.2008.03.045.
- Sa.109. Allelic and Phenotypic Heterogeneity at the Autoimmune Susceptibility Locus IL2RAMaier L, Severson C, De Jager P, Hafler D. Sa.109. Allelic and Phenotypic Heterogeneity at the Autoimmune Susceptibility Locus IL2RA. Clinical Immunology 2008, 127: s116. DOI: 10.1016/j.clim.2008.03.330.
- F.34. Changes in the CD8dimCD4- Cell Population Parallel Disease Activity in Treated Multiple Sclerosis SubjectsDe Jager P, Kivisäkk P, Hu X, Soler-Ferran D, Izmailova E, O'Brien C, Hafler D, Weiner H, Khoury S. F.34. Changes in the CD8dimCD4- Cell Population Parallel Disease Activity in Treated Multiple Sclerosis Subjects. Clinical Immunology 2008, 127: s54. DOI: 10.1016/j.clim.2008.03.146.
- Su.86. Automated High-dimensional Flow Cytometric Data AnalysisHu X, Pyne S, Rossin E, Tamayo P, Hafler D, Mesirov J, De Jager P. Su.86. Automated High-dimensional Flow Cytometric Data Analysis. Clinical Immunology 2008, 127: s152. DOI: 10.1016/j.clim.2008.03.437.
- Sa.114. IL-10 and Granzyme B Inhibits Suppression by Human DR+ Effector nTregsBaecher-Allan C, Ashley C, Hafler D. Sa.114. IL-10 and Granzyme B Inhibits Suppression by Human DR+ Effector nTregs. Clinical Immunology 2008, 127: s117-s118. DOI: 10.1016/j.clim.2008.03.335.
- F.33. Genetic Variants that Control the Expression of MHC Genes Do Not Affect Susceptibility to Multiple SclerosisOttoboni L, Young E, Yelensky R, Hafler D, Daly M, De Jager P. F.33. Genetic Variants that Control the Expression of MHC Genes Do Not Affect Susceptibility to Multiple Sclerosis. Clinical Immunology 2008, 127: s53-s54. DOI: 10.1016/j.clim.2008.03.145.
- Sa.115. IL7R and HLA-Class II selected FoxP3+ Natural Regulatory T Cells (nTregs) Represent Effector nTregs, Precursor nTregs, and Induced nTregsBaecher-Allan C, Maier L, Beriou G, Ashley C, Hafler D. Sa.115. IL7R and HLA-Class II selected FoxP3+ Natural Regulatory T Cells (nTregs) Represent Effector nTregs, Precursor nTregs, and Induced nTregs. Clinical Immunology 2008, 127: s118. DOI: 10.1016/j.clim.2008.03.336.
- Allelic variant in CTLA4 alters T cell phosphorylation patternsMaier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA. Allelic variant in CTLA4 alters T cell phosphorylation patterns. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 18607-18612. PMID: 18000051, PMCID: PMC2141824, DOI: 10.1073/pnas.0706409104.
- Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune CellsAnderson AC, Anderson DE, Bregoli L, Hastings WD, Kassam N, Lei C, Chandwaskar R, Karman J, Su EW, Hirashima M, Bruce JN, Kane LP, Kuchroo VK, Hafler DA. Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells. Science 2007, 318: 1141-1143. PMID: 18006747, DOI: 10.1126/science.1148536.
- Two independent alleles at 6q23 associated with risk of rheumatoid arthritisPlenge RM, Cotsapas C, Davies L, Price AL, de Bakker PI, Maller J, Pe'er I, Burtt NP, Blumenstiel B, DeFelice M, Parkin M, Barry R, Winslow W, Healy C, Graham RR, Neale BM, Izmailova E, Roubenoff R, Parker AN, Glass R, Karlson EW, Maher N, Hafler DA, Lee DM, Seldin MF, Remmers EF, Lee AT, Padyukov L, Alfredsson L, Coblyn J, Weinblatt ME, Gabriel SB, Purcell S, Klareskog L, Gregersen PK, Shadick NA, Daly MJ, Altshuler D. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nature Genetics 2007, 39: 1477-1482. PMID: 17982456, PMCID: PMC2652744, DOI: 10.1038/ng.2007.27.
- Abnormal Tr1 differentiation in multiple sclerosisAstier AL, Hafler DA. Abnormal Tr1 differentiation in multiple sclerosis. Journal Of Neuroimmunology 2007, 191: 70-78. PMID: 17936368, PMCID: PMC2200628, DOI: 10.1016/j.jneuroim.2007.09.018.
- Risk Alleles for Multiple Sclerosis Identified by a Genomewide StudyHafler D, Compston A, Sawcer S, Lander E, Daly M, De Jager P, de Bakker P, Gabriel S, Mirel D, Ivinson A, Pericak-Vance M, Gregory S, Rioux J, McCauley J, Haines J, Barcellos L, Cree B, Oksenberg J, Hauser S. Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. New England Journal Of Medicine 2007, 357: 851-862. PMID: 17660530, DOI: 10.1056/nejmoa073493.
- Protective and therapeutic role for αB-crystallin in autoimmune demyelinationOusman SS, Tomooka BH, van Noort JM, Wawrousek EF, O’Conner K, Hafler DA, Sobel RA, Robinson WH, Steinman L. Protective and therapeutic role for αB-crystallin in autoimmune demyelination. Nature 2007, 448: 474-479. PMID: 17568699, DOI: 10.1038/nature05935.
- Cytokines and interventional immunologyHafler D. Cytokines and interventional immunology. Nature Reviews Immunology 2007, 7: 423-423. DOI: 10.1038/nri2101.
- The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseasesDe Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes & Immunity 2007, 8: 387-397. PMID: 17538633, DOI: 10.1038/sj.gene.6364398.
- Polyspecificity of T cell and B cell receptor recognitionWucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE. Polyspecificity of T cell and B cell receptor recognition. Seminars In Immunology 2007, 19: 216-224. PMID: 17398114, PMCID: PMC2034306, DOI: 10.1016/j.smim.2007.02.012.
- Multispecific responses by T cells expanded by endogenous self‐peptide/MHC complexesCai G, Hafler DA. Multispecific responses by T cells expanded by endogenous self‐peptide/MHC complexes. European Journal Of Immunology 2007, 37: 602-612. PMID: 17304631, DOI: 10.1002/eji.200636787.
- New Therapeutic Approaches for Multiple SclerosisDe Jager PL, Hafler DA. New Therapeutic Approaches for Multiple Sclerosis. Annual Review Of Medicine 2007, 58: 417-432. PMID: 17217332, DOI: 10.1146/annurev.med.58.071105.111552.
- Detection of autoantibodies with self-assembling radiolabeled antigen tetramersMcLaughlin K, O'Connor K, Hafler D, Wucherpfennig K. Detection of autoantibodies with self-assembling radiolabeled antigen tetramers. Protocol Exchange 2007 DOI: 10.1038/nprot.2007.81.
- A second major histocompatibility complex susceptibility locus for multiple sclerosisYeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S, . A second major histocompatibility complex susceptibility locus for multiple sclerosis. Annals Of Neurology 2007, 61: 228-236. PMID: 17252545, PMCID: PMC2737610, DOI: 10.1002/ana.21063.
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured proteinO'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nature Medicine 2007, 13: 211-217. PMID: 17237795, PMCID: PMC3429369, DOI: 10.1038/nm1488.
- A Local Antigen-Driven Humoral Response Is Present in the Inflammatory MyopathiesBradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O’Connor K. A Local Antigen-Driven Humoral Response Is Present in the Inflammatory Myopathies. The Journal Of Immunology 2007, 178: 547-556. PMID: 17182595, DOI: 10.4049/jimmunol.178.1.547.
- Characterization of the B Cell Infiltrate Within Intracranial GerminomasMcArdel S, Cronk K, Shampain K, Anderson R, Anderson D, Bruce J, Hafler D, O'Connor K. Characterization of the B Cell Infiltrate Within Intracranial Germinomas. Clinical Immunology 2007, 123: s113. DOI: 10.1016/j.clim.2007.03.501.
- Characterization of Single B Cell Immunoglobulin Variable Region Genes Derived from Infiltrated Muscle Tissue of Subjects with Inflammatory MyopathiesBradshaw E, Orihuela A, McArdel S, Hafler D, Amato A, O'Connor K. Characterization of Single B Cell Immunoglobulin Variable Region Genes Derived from Infiltrated Muscle Tissue of Subjects with Inflammatory Myopathies. Clinical Immunology 2007, 123: s152. DOI: 10.1016/j.clim.2007.03.072.
- How B Cells Contribute to Multiple Sclerosis PathologyO'Connor K, Cherry S, Hafler D. How B Cells Contribute to Multiple Sclerosis Pathology. 2007, 66-86. DOI: 10.1007/978-0-387-36003-4_5.
- Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and SurvivalManzanet R, Hartt-Meyers J, Slavik J, Dardalhon V, Kassam N, Greenfield E, Sobel R, Strom T, Hafler D, Kuchroo V. Tim-4 Expressed on Antigen-presenting Cells Induces T Cell Expansion and Survival. Clinical Immunology 2007, 123: s124-s125. DOI: 10.1016/j.clim.2007.03.533.
- Defect in TIM-3 Regulation of CD4+ T Cells in a Human Autoimmune DiseaseYang L, Anderson D, Kuchroo V, Hafler D. Defect in TIM-3 Regulation of CD4+ T Cells in a Human Autoimmune Disease. Clinical Immunology 2007, 123: s139-s140. DOI: 10.1016/j.clim.2007.03.035.
- Dysregulation of the TIM-3-Galectin-9 Pathway in Type I Diabetic T CellsHastings W, Greer A, Kuchroo V, Hafler D, Kent S, Anderson D. Dysregulation of the TIM-3-Galectin-9 Pathway in Type I Diabetic T Cells. Clinical Immunology 2007, 123: s21. DOI: 10.1016/j.clim.2007.03.228.
- Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting CellsCostanti-England C, Hang H, Hafler D, Ploegh H. Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting Cells. Clinical Immunology 2007, 123: s53. DOI: 10.1016/j.clim.2007.03.330.
- IL-10 Both Inhibits Treg Suppressive Activity and is a Survival Factor for Human Natural TregsBaecher-Allan C, Ashley C, Hafler D. IL-10 Both Inhibits Treg Suppressive Activity and is a Survival Factor for Human Natural Tregs. Clinical Immunology 2007, 123: s133. DOI: 10.1016/j.clim.2007.03.017.
- Admixture Mapping, a New Tool for Disease Gene Finding in Autoimmune and Other DiseasesWaliszewska A, De Jager P, Hafler D, Reich D. Admixture Mapping, a New Tool for Disease Gene Finding in Autoimmune and Other Diseases. Clinical Immunology 2007, 123: s122. DOI: 10.1016/j.clim.2007.03.526.
- Protective and Therapeutic Role for α B-Crystallin in Autoimmune DemyelinationOusman S, Tomooka B, Van Noort J, O'Conner K, Wawrousek E, Hafler D, Sobel R, Robinson W, Steinman L. Protective and Therapeutic Role for α B-Crystallin in Autoimmune Demyelination. Clinical Immunology 2007, 123: s139. DOI: 10.1016/j.clim.2007.03.034.
- Improving Elispot to Detect Antigen Specific T CellsRaddassi K, Bourcier K, Estevam J, Seyfert-Margolis V, Hafler D. Improving Elispot to Detect Antigen Specific T Cells. Clinical Immunology 2007, 123: s154. DOI: 10.1016/j.clim.2007.03.078.
- A Genome-wide Screen for Genetic Variants Affecting the Expression of Immunologically Relevant Cell Surface MarkersDe Jager P, Yelensky R, Rossin E, Bonadkar S, Choy E, Daly M, Altshuler D, Hafler D. A Genome-wide Screen for Genetic Variants Affecting the Expression of Immunologically Relevant Cell Surface Markers. Clinical Immunology 2007, 123: s153. DOI: 10.1016/j.clim.2007.03.076.
- Elifacs: A Multiplex Assay to Detect Antigen Specific T Cells and to Monitor the Immune ResponseRaddassi K, Bouchier K, Estevam J, Seyfert-Margolis V, Hafler D. Elifacs: A Multiplex Assay to Detect Antigen Specific T Cells and to Monitor the Immune Response. Clinical Immunology 2007, 123: s126. DOI: 10.1016/j.clim.2007.03.538.
- Novel Computational Methods to Enhance the Analysis of Cytometric ImmunophenotypesDe Jager P, Pyne S, Rossin E, Mesirov J, Tamayo P, Hafler D. Novel Computational Methods to Enhance the Analysis of Cytometric Immunophenotypes. Clinical Immunology 2007, 123: s153-s154. DOI: 10.1016/j.clim.2007.03.077.
- Large Scale Immunoprofiling Uncovers Population Structure in Untreated MS Subjects and Highlights the Role of NK CellsRossin E, Viglietta V, Soler-Ferran D, Parker A, Weiner M, Buckle G, Khoury S, Hafler D, Weiner H, De Jager P. Large Scale Immunoprofiling Uncovers Population Structure in Untreated MS Subjects and Highlights the Role of NK Cells. Clinical Immunology 2007, 123: s151. DOI: 10.1016/j.clim.2007.03.068.
- Human Glioblastoma Multiforme (GBM) Tumors are Enriched for Strongly Suppressive, Apoptosis Resistant, DR+ TregsAshley C, Anderson R, Bruce J, Anderson D, Hafler D, Baecher-Allan C. Human Glioblastoma Multiforme (GBM) Tumors are Enriched for Strongly Suppressive, Apoptosis Resistant, DR+ Tregs. Clinical Immunology 2007, 123: s115. DOI: 10.1016/j.clim.2007.03.507.
- TIM-3 is a Negative Regulator of Human Th1 CellsAnderson D, Kuchroo J, Kassam N, Hafler D. TIM-3 is a Negative Regulator of Human Th1 Cells. Clinical Immunology 2007, 123: s154. DOI: 10.1016/j.clim.2007.03.079.
- An Association Between the Autoimmune Susceptibility Locus CTLA4 and Alterations in Proximal TCR Signaling in Healthy Human VolunteersMaier L, Anderson D, de Jager P, Hafler D, Wicker L. An Association Between the Autoimmune Susceptibility Locus CTLA4 and Alterations in Proximal TCR Signaling in Healthy Human Volunteers. Clinical Immunology 2007, 123: s135. DOI: 10.1016/j.clim.2007.03.023.
- Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative BiomarkersO’Connor K, Roy SM, Becker CH, Hafler DA, Kantor AB. Comprehensive Phenotyping in Multiple Sclerosis: Discovery Based Proteomics and the Current Understanding of Putative Biomarkers. Disease Markers 2006, 22: 213-225. PMID: 17124343, PMCID: PMC3851054, DOI: 10.1155/2006/670439.
- Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosisAstier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. Journal Of Clinical Investigation 2006, 116: 3252-3257. PMID: 17099776, PMCID: PMC1635165, DOI: 10.1172/jci29251.
- A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHCde Bakker PI, McVean G, Sabeti PC, Miretti MM, Green T, Marchini J, Ke X, Monsuur AJ, Whittaker P, Delgado M, Morrison J, Richardson A, Walsh EC, Gao X, Galver L, Hart J, Hafler DA, Pericak-Vance M, Todd JA, Daly MJ, Trowsdale J, Wijmenga C, Vyse TJ, Beck S, Murray SS, Carrington M, Gregory S, Deloukas P, Rioux JD. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nature Genetics 2006, 38: 1166-1172. PMID: 16998491, PMCID: PMC2670196, DOI: 10.1038/ng1885.
- Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune ResponseKarni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response. The Journal Of Immunology 2006, 177: 4196-4202. PMID: 16951385, DOI: 10.4049/jimmunol.177.6.4196.
- Human regulatory T cells and their role in autoimmune diseaseBaecher‐Allan C, Hafler DA. Human regulatory T cells and their role in autoimmune disease. Immunological Reviews 2006, 212: 203-216. PMID: 16903916, DOI: 10.1111/j.0105-2896.2006.00417.x.
- Dysregulated T cell expression of TIM3 in multiple sclerosisKoguchi K, Anderson DE, Yang L, O'Connor KC, Kuchroo VK, Hafler DA. Dysregulated T cell expression of TIM3 in multiple sclerosis. Journal Of Experimental Medicine 2006, 203: 1413-1418. PMID: 16754722, PMCID: PMC2118310, DOI: 10.1084/jem.20060210.
- The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosusDe Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus. Genes & Immunity 2006, 7: 327-334. PMID: 16642031, DOI: 10.1038/sj.gene.6364303.
- MHC Class II Expression Identifies Functionally Distinct Human Regulatory T CellsBaecher-Allan C, Wolf E, Hafler DA. MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells. The Journal Of Immunology 2006, 176: 4622-4631. PMID: 16585553, DOI: 10.4049/jimmunol.176.8.4622.
- The Purification and Functional Analysis of Human CD4+CD25high Regulatory T CellsBaecher-Allan C, Hafler DA. The Purification and Functional Analysis of Human CD4+CD25high Regulatory T Cells. Current Protocols In Immunology 2006, 72: 7.4b.1-7.4b.12. PMID: 18432975, DOI: 10.1002/0471142735.im0704bs72.
- Sa.30. Characterization of B-Cell Immunoglobulin Variable Region Genes Derived from Muscle Tissue of Subjects with Inflammatory MyopathiesBradshaw E, Orihuela A, Amato A, Hafler D, Greenberg S, O'Connor K. Sa.30. Characterization of B-Cell Immunoglobulin Variable Region Genes Derived from Muscle Tissue of Subjects with Inflammatory Myopathies. Clinical Immunology 2006, 119: s115. DOI: 10.1016/j.clim.2006.04.262.
- Sa.9. Examination of the B-Cell Repertoire in the CNS of Patients with MSO'Connor K, McArdel S, Bradshaw E, Anderson D, Moore N, Brady M, Hafler D. Sa.9. Examination of the B-Cell Repertoire in the CNS of Patients with MS. Clinical Immunology 2006, 119: s108. DOI: 10.1016/j.clim.2006.04.241.
- Analysis of Autoreactive T-Cells in Type I DiabetesHastings W, Kent S, Kuchroo V, Hafler D. Analysis of Autoreactive T-Cells in Type I Diabetes. Clinical Immunology 2006, 119: s44. DOI: 10.1016/j.clim.2006.04.411.
- F.108. Further Characterizations of Human CD4+ CD25+ Regulatory T-CellsBander J, Baecher-Allan C, Hafler D. F.108. Further Characterizations of Human CD4+ CD25+ Regulatory T-Cells. Clinical Immunology 2006, 119: s88-s89. DOI: 10.1016/j.clim.2006.04.148.
- Sa.25. In Vitro Correlates of in Vivo Rapamycin Therapy in Patients with Multiple SclerosisSlavik J, Viglietta V, Bourcier K, Grinberg I, Khoury S, Hafler D. Sa.25. In Vitro Correlates of in Vivo Rapamycin Therapy in Patients with Multiple Sclerosis. Clinical Immunology 2006, 119: s113. DOI: 10.1016/j.clim.2006.04.257.
- CHAPTER 46 Multiple SclerosisBRASS S, WEINER H, HAFLER D. CHAPTER 46 Multiple Sclerosis. 2006, 615-632. DOI: 10.1016/b978-012595961-2/50049-4.
- Sa.13. Function of TIM3 May Be Compromised in Human CD4 T-Cells of Untreated Patients with Multiple SclerosisYang L, Anderson D, Hafler D. Sa.13. Function of TIM3 May Be Compromised in Human CD4 T-Cells of Untreated Patients with Multiple Sclerosis. Clinical Immunology 2006, 119: s109. DOI: 10.1016/j.clim.2006.04.245.
- OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi LibraryAstier A, Beriou G, Eisenhaure T, Hafler D, Hacohen N. OR.80. Identifying Regulators of Cytokine Production in Primary Human T-Cells Using a Lentiviral RNAi Library. Clinical Immunology 2006, 119: s35. DOI: 10.1016/j.clim.2006.04.385.
- OR.9. Il-10 Plays a Contrasting Role in Suppression By Functionally Distinct, Dr+ and Dr− Human Natural Regulatory T-CellsBaecher-Allan C, Ashley C, Hafler D. OR.9. Il-10 Plays a Contrasting Role in Suppression By Functionally Distinct, Dr+ and Dr− Human Natural Regulatory T-Cells. Clinical Immunology 2006, 119: s7. DOI: 10.1016/j.clim.2006.04.011.
- OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph NodesKent S, Hafler D. OR.72. Enhanced Recognition of Insulin a Chain 1-15 By Expanded T-Cell Clones from Human Type 1 Diabetic (T1D) Pancreatic Draining Lymph Nodes. Clinical Immunology 2006, 119: s30-s31. DOI: 10.1016/j.clim.2006.04.228.
- Sa.43. Role of the HLA DRB1*1501 Risk Haplotype in the Expression of Clinical and Radiographic Phenotypes of Multiple SclerosisDe Jager P, Charles G, Wolfish C, Holland C, Alkasab T, Parker A, Roubenoff R, Khoury S, Hafler D, Weiner H. Sa.43. Role of the HLA DRB1*1501 Risk Haplotype in the Expression of Clinical and Radiographic Phenotypes of Multiple Sclerosis. Clinical Immunology 2006, 119: s120. DOI: 10.1016/j.clim.2006.04.275.
- Sa.27. Genotype/Phenotype and Epistasis Analyses of Toll-Like Receptor Pathway Alleles Associated with Risk of Inflammatory Bowel DiseaseWaliszewska A, De Jager P, Franchimont D, Hafler D, Rioux J. Sa.27. Genotype/Phenotype and Epistasis Analyses of Toll-Like Receptor Pathway Alleles Associated with Risk of Inflammatory Bowel Disease. Clinical Immunology 2006, 119: s114. DOI: 10.1016/j.clim.2006.04.259.
- OR.22. Dissection of the Admixture Multiple Sclerosis Susceptibility Locus On Chromosome 1 in An African-American PopulationDe Jager P, Patterson N, McDonald G, Waliszewska A, Cree B, Wolfish C, Hauser S, Oksenberg J, Reich D, Hafler D. OR.22. Dissection of the Admixture Multiple Sclerosis Susceptibility Locus On Chromosome 1 in An African-American Population. Clinical Immunology 2006, 119: s12. DOI: 10.1016/j.clim.2006.04.024.
- Sa.137. Toll-Like Receptor Pathway Polymorphisms and Association to Inflammatory Bowel DiseaseDe Jager P, Franchimont D, Waliszewska A, Bitton A, Cohen A, Belaiche J, Langelier D, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Gillian B, Dubois B, Cho J, Brant S, Duerr R, Yang H, Rotter J, Silverberg M, Steinhart H, Daly M, Louis E, Hafler D, Rioux J. Sa.137. Toll-Like Receptor Pathway Polymorphisms and Association to Inflammatory Bowel Disease. Clinical Immunology 2006, 119: s154. DOI: 10.1016/j.clim.2006.04.369.
- Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous AntigenCostantino C, Ploegh H, Baecher-Allan C, Hafler D. Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous Antigen. Clinical Immunology 2006, 119: s151. DOI: 10.1016/j.clim.2006.04.362.
- Sa.128. Comparison of Two Methods to Isolate Mononuclear Cells from Peripheral Blood On Viability and Function of Freshly and Cryopreserved PBMCSRaddassi K, Estevam J, Bourcier K, Gisler T, Hafler D, Seyfert-Margolis V. Sa.128. Comparison of Two Methods to Isolate Mononuclear Cells from Peripheral Blood On Viability and Function of Freshly and Cryopreserved PBMCS. Clinical Immunology 2006, 119: s150-s151. DOI: 10.1016/j.clim.2006.04.360.
- Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosisDe Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD. Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis. European Journal Of Human Genetics 2005, 14: 317-321. PMID: 16391555, DOI: 10.1038/sj.ejhg.5201548.
- Insulin auto-antigenicity in type 1 diabetes (Reply)Hafler D, Kent S, Chen Y, Bregoli L, Clemmings S, Hering B, Kenyon N, Ricordi C. Insulin auto-antigenicity in type 1 diabetes (Reply). Nature 2005, 438: e5-e6. DOI: 10.1038/nature04424.
- Letter to the EditorBaecher-Allan CM, Hafler DA. Letter to the Editor. Clinical Immunology 2005, 117: 192. PMID: 16214081, DOI: 10.1016/j.clim.2005.08.008.
- Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT CellsKent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells. The Journal Of Immunology 2005, 175: 4458-4464. PMID: 16177088, DOI: 10.4049/jimmunol.175.7.4458.
- A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibilityReich D, Patterson N, Jager P, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nature Genetics 2005, 37: 1113-1118. PMID: 16186815, DOI: 10.1038/ng1646.
- Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte GlycoproteinO’Connor K, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein. The Journal Of Immunology 2005, 175: 1974-1982. PMID: 16034142, PMCID: PMC4515951, DOI: 10.4049/jimmunol.175.3.1974.
- A High-Density Screen for Linkage in Multiple SclerosisSawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. A High-Density Screen for Linkage in Multiple Sclerosis. American Journal Of Human Genetics 2005, 77: 454-467. PMID: 16080120, PMCID: PMC1226210, DOI: 10.1086/444547.
- Characterization of in vivo expanded OspA-specific human T-cell clonesAusubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology 2005, 115: 313-322. PMID: 15893699, DOI: 10.1016/j.clim.2005.02.015.
- Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitopeKent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005, 435: 224-228. PMID: 15889096, DOI: 10.1038/nature03625.
- Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cellsBaecher-Allan C, Wolf E, Hafler DA. Functional analysis of highly defined, FACS-isolated populations of human regulatory CD4+CD25+ T cells. Clinical Immunology 2005, 115: 10-18. PMID: 15870015, DOI: 10.1016/j.clim.2005.02.018.
- Multiple sclerosisHafler DA, Slavik JM, Anderson DE, O'Connor KC, De Jager P, Baecher‐Allan C. Multiple sclerosis. Immunological Reviews 2005, 204: 208-231. PMID: 15790361, DOI: 10.1111/j.0105-2896.2005.00240.x.
- High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis ModelEllmerich S, Mycko M, Takacs K, Waldner H, Wahid FN, Boyton RJ, King RH, Smith PA, Amor S, Herlihy AH, Hewitt RE, Jutton M, Price DA, Hafler DA, Kuchroo VK, Altmann DM. High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model. The Journal Of Immunology 2005, 174: 1938-1946. PMID: 15699121, DOI: 10.4049/jimmunol.174.4.1938.
- Applying a new generation of genetic maps to understand human inflammatory diseaseHafler DA, Jager P. Applying a new generation of genetic maps to understand human inflammatory disease. Nature Reviews Immunology 2005, 5: 83-91. PMID: 15630431, DOI: 10.1038/nri1532.
- The potential for targeting CD4+CD25+ regulatory T cells in the treatment of multiple sclerosis in humansBaecher-Allan C, Viglietta V, Hafler D. The potential for targeting CD4+CD25+ regulatory T cells in the treatment of multiple sclerosis in humans. 2005, 133-151. DOI: 10.1007/3-7643-7301-6_8.
- PD-1 ligands, negative regulators for activation of naïve, memory, and recently activated human CD4+ T cellsCai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naïve, memory, and recently activated human CD4+ T cells. Cellular Immunology 2004, 230: 89-98. PMID: 15598424, DOI: 10.1016/j.cellimm.2004.09.004.
- Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II MoleculesMycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-Reactive TCR Responses to Self Antigens Presented by Different MHC Class II Molecules. The Journal Of Immunology 2004, 173: 1689-1698. PMID: 15265898, DOI: 10.4049/jimmunol.173.3.1689.
- Re: GAMES issue study: Are international genetic consortia functional?De Jager PL, Walsh EC, Rioux JD, Hafler DA. Re: GAMES issue study: Are international genetic consortia functional? Journal Of Neuroimmunology 2004, 153: 5-6. PMID: 15334748.
- Suppressor T Cells in Human DiseasesBaecher-Allan C, Hafler DA. Suppressor T Cells in Human Diseases. Journal Of Experimental Medicine 2004, 200: 273-276. PMID: 15280423, PMCID: PMC2211973, DOI: 10.1084/jem.20040812.
- Enhancing linkage analysis of complex disorders: an evaluation of high-density genotypingSawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Human Molecular Genetics 2004, 13: 1943-1949. PMID: 15238506, DOI: 10.1093/hmg/ddh202.
- Disease‐related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosisEllmerich S, Takacs K, Mycko M, Waldner H, Wahid F, Boyton RJ, Smith PA, Amor S, Baker D, Hafler DA, Kuchroo VK, Altmann DM. Disease‐related epitope spread in a humanized T cell receptor transgenic model of multiple sclerosis. European Journal Of Immunology 2004, 34: 1839-1848. PMID: 15214032, DOI: 10.1002/eji.200324044.
- T Cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-Derived Mononuclear Cells in Multiple SclerosisKhademi M, Illés Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C, Brundin L, Hannerz J, Martin C, Harris RA, Hafler DA, Kuchroo VK, Olsson T, Piehl F, Wallström E. T Cell Ig- and Mucin-Domain-Containing Molecule-3 (TIM-3) and TIM-1 Molecules Are Differentially Expressed on Human Th1 and Th2 Cells and in Cerebrospinal Fluid-Derived Mononuclear Cells in Multiple Sclerosis. The Journal Of Immunology 2004, 172: 7169-7176. PMID: 15153541, DOI: 10.4049/jimmunol.172.11.7169.
- An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T CellsVijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells. Immunity 2004, 20: 563-575. PMID: 15142525, DOI: 10.1016/s1074-7613(04)00110-4.
- Gene expression profiling in MS: what is the clinical relevance?De Jager PL, Hafler DA. Gene expression profiling in MS: what is the clinical relevance? The Lancet Neurology 2004, 3: 269. PMID: 15099539, DOI: 10.1016/s1474-4422(04)00731-8.
- Methods for High-Density Admixture Mapping of Disease GenesPatterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O’Brien S, Altshuler D, Daly MJ, Reich D. Methods for High-Density Admixture Mapping of Disease Genes. American Journal Of Human Genetics 2004, 74: 979-1000. PMID: 15088269, PMCID: PMC1181990, DOI: 10.1086/420871.
- A High-Density Admixture Map for Disease Gene Discovery in African AmericansSmith MW, Patterson N, Lautenberger JA, Truelove AL, McDonald GJ, Waliszewska A, Kessing BD, Malasky MJ, Scafe C, Le E, De Jager PL, Mignault AA, Yi Z, de Thé G, Essex M, Sankalé J, Moore JH, Poku K, Phair JP, Goedert JJ, Vlahov D, Williams SM, Tishkoff SA, Winkler CA, De La Vega FM, Woodage T, Sninsky JJ, Hafler DA, Altshuler D, Gilbert DA, O’Brien S, Reich D. A High-Density Admixture Map for Disease Gene Discovery in African Americans. American Journal Of Human Genetics 2004, 74: 1001-1013. PMID: 15088270, PMCID: PMC1181963, DOI: 10.1086/420856.
- Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple SclerosisViglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis. Journal Of Experimental Medicine 2004, 199: 971-979. PMID: 15067033, PMCID: PMC2211881, DOI: 10.1084/jem.20031579.
- Human CD4+CD25+ regulatory T cellsBaecher-Allan C, Viglietta V, Hafler DA. Human CD4+CD25+ regulatory T cells. Seminars In Immunology 2004, 16: 89-98. PMID: 15036232, DOI: 10.1016/j.smim.2003.12.005.
- Regulatory T cells in type 1 diabetes mellitusViglietta V, Baecher-Allan C, Hafler A, Gottlieb P. Regulatory T cells in type 1 diabetes mellitus. Current Opinion In Endocrinology Diabetes And Obesity 2004, 11: 85-90. DOI: 10.1097/01.med.0000129641.34639.2e.
- Multiple sclerosisHafler D. Multiple sclerosis. Journal Of Clinical Investigation 2004, 113: 1070-1070. PMCID: PMC380239, DOI: 10.1172/jci200421357c.
- Multiple sclerosisHafler DA. Multiple sclerosis. Journal Of Clinical Investigation 2004, 113: 788-794. PMID: 15067307, PMCID: PMC362131, DOI: 10.1172/jci21357.
- 4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL)Lim D, Hafler D. 4 Molecular Mimicry in Multiple Sclerosis Role of MHC-Altered Peptide Ligands (MAPL). 2004, 45-55. PMCID: PMC7151874, DOI: 10.1016/b978-044451271-0.50004-1.
- Molecular Mimicry in Multiple SclerosisRole of MHC-Altered Peptide Ligands (MAPL)LIM D, HAFLER D. Molecular Mimicry in Multiple SclerosisRole of MHC-Altered Peptide Ligands (MAPL). 2004, 45-55. DOI: 10.1016/b978-044451271-0/50004-1.
- Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and Is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity*Slavik JM, Lim DG, Burakoff SJ, Hafler DA. Rapamycin-resistant Proliferation of CD8+ T Cells Correlates with p27 kip1 Down-regulation and bcl-xL Induction, and Is Prevented by an Inhibitor of Phosphoinositide 3-Kinase Activity*. Journal Of Biological Chemistry 2003, 279: 910-919. PMID: 14573608, DOI: 10.1074/jbc.m209733200.
- Genetic analysis of multiple sclerosisWalsh EC, Guschwan-McMahon S, Daly MJ, Hafler DA, Rioux JD. Genetic analysis of multiple sclerosis. Journal Of Autoimmunity 2003, 21: 111-116. PMID: 12935779, DOI: 10.1016/s0896-8411(03)00094-5.
- Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell FunctionLim DG, Slavik JM, Bourcier K, Smith KJ, Hafler DA. Allelic Variation of MHC Structure Alters Peptide Ligands to Induce Atypical Partial Agonistic CD8+ T Cell Function. Journal Of Experimental Medicine 2003, 198: 99-109. PMID: 12847139, PMCID: PMC2196091, DOI: 10.1084/jem.20021796.
- Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactionsO'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. Journal Of Neuroimmunology 2003, 136: 140-148. PMID: 12620653, DOI: 10.1016/s0165-5728(03)00002-x.
- In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosisSchmied M, Duda PW, Krieger JI, Trollmo C, Hafler DA. In vitro evidence that subcutaneous administration of glatiramer acetate induces hyporesponsive T cells in patients with multiple sclerosis. Clinical Immunology 2003, 106: 163-174. PMID: 12706402, DOI: 10.1016/s1521-6616(03)00020-2.
- Activated CD8+ T cells in secondary progressive MS secrete lymphotoxinBuckle GJ, Höllsberg P, Hafler DA. Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin. Neurology 2003, 60: 702-705. PMID: 12601116, DOI: 10.1212/01.wnl.0000048204.89346.30.
- CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controlsOliveira EM, Bar-Or A, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls. Journal Of Autoimmunity 2003, 20: 71-81. PMID: 12604314, DOI: 10.1016/s0896-8411(02)00106-3.
- Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritisCao D, Malmström V, Baecher‐Allan C, Hafler D, Klareskog L, Trollmo C. Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis. European Journal Of Immunology 2003, 33: 215-223. PMID: 12594850, DOI: 10.1002/immu.200390024.
- CTLA4 is associated with susceptibility to multiple sclerosisKantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis. Journal Of Neuroimmunology 2003, 134: 133-141. PMID: 12507781, DOI: 10.1016/s0165-5728(02)00395-8.
- CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex VivoBaecher‐Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo. 2003, 252: 67-91. PMID: 14609213, DOI: 10.1002/0470871628.ch6.
- Human T-Lymphotropic Viruses (HTLVs)Dangond F, Hafler D. Human T-Lymphotropic Viruses (HTLVs). 2003, 596-598. DOI: 10.1016/b0-12-226870-9/00275-6.
- Inhibition of Human CD4+CD25+high Regulatory T Cell FunctionBaecher-Allan C, Viglietta V, Hafler DA. Inhibition of Human CD4+CD25+high Regulatory T Cell Function. The Journal Of Immunology 2002, 169: 6210-6217. PMID: 12444126, DOI: 10.4049/jimmunol.169.11.6210.
- GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetesViglietta V, Kent S, Orban T, Hafler D. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. Journal Of Clinical Investigation 2002, 109: 1511-1511. DOI: 10.1172/jci14114c1.
- Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cellsLim DG, Höllsberg P, Hafler DA. Strength of prior stimuli determines the magnitude of secondary responsiveness in CD8+ T cells. Cellular Immunology 2002, 217: 36-46. PMID: 12425999, DOI: 10.1016/s0008-8749(02)00511-7.
- GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetesViglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. Journal Of Clinical Investigation 2002, 109: 895-903. PMID: 11927616, PMCID: PMC150925, DOI: 10.1172/jci14114.
- Degeneracy, as opposed to specificity, in immunotherapyHafler DA. Degeneracy, as opposed to specificity, in immunotherapy. Journal Of Clinical Investigation 2002, 109: 581-584. PMID: 11877465, PMCID: PMC150898, DOI: 10.1172/jci15198.
- Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting StateBar-Or A, Oliveira E, Anderson D, Krieger J, Duddy M, O’Connor K, Hafler D. Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. The Journal Of Immunology 2001, 167: 5669-5677. PMID: 11698439, DOI: 10.4049/jimmunol.167.10.5669.
- Cytokines and Human Type 1 DiabetesKent S, Viglietta V, Hafler D. Cytokines and Human Type 1 Diabetes. 2001, 0: 295-316. DOI: 10.1385/1-59259-129-9:295.
- Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal StructureBourcier K, Lim D, Ding Y, Smith K, Wucherpfennig K, Hafler D. Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure. Journal Of Virology 2001, 75: 9836-9843. PMID: 11559817, PMCID: PMC114556, DOI: 10.1128/jvi.75.20.9836-9843.2001.
- In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOGOhashi T, Yukitake M, Slavin A, Krieger J, Hafler D. In vitro evidence that immunuaffinity-purified MOG contains immunogenic quantities of contaminating mouse IgG; techniques for producing Ig-free MOG. Journal Of Neuroimmunology 2001, 118: 194-202. PMID: 11498254, DOI: 10.1016/s0165-5728(01)00321-6.
- CD4+CD25high Regulatory Cells in Human Peripheral BloodBaecher-Allan C, Brown J, Freeman G, Hafler D. CD4+CD25high Regulatory Cells in Human Peripheral Blood. The Journal Of Immunology 2001, 167: 1245-1253. PMID: 11466340, DOI: 10.4049/jimmunol.167.3.1245.
- Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T CellsTrollmo C, Meyer A, Steere A, Hafler D, Huber B. Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1αL Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells. The Journal Of Immunology 2001, 166: 5286-5291. PMID: 11290815, DOI: 10.4049/jimmunol.166.8.5286.
- Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T LymphocytesSlavik J, Lim D, Burakoff S, Hafler D. Uncoupling p70s6 Kinase Activation and Proliferation: Rapamycin-Resistant Proliferation of Human CD8+ T Lymphocytes. The Journal Of Immunology 2001, 166: 3201-3209. PMID: 11207273, DOI: 10.4049/jimmunol.166.5.3201.
- The Neuroimmunology of Multiple Sclerosis: Possible Roles of T and B Lymphocytes in ImmunopathogenesisO'connor K, Bar-Or A, Hafler D. The Neuroimmunology of Multiple Sclerosis: Possible Roles of T and B Lymphocytes in Immunopathogenesis. Journal Of Clinical Immunology 2001, 21: 81-92. PMID: 11332657, DOI: 10.1023/a:1011064007686.
- Enhanced B7 Costimulatory Molecule Expression In Inflammatory Human Sural Nerve BiopsiesKiefer R, Dangond F, Mueller M, Toyka K, Hafler D, Hartung H. Enhanced B7 Costimulatory Molecule Expression In Inflammatory Human Sural Nerve Biopsies. Journal Of The Peripheral Nervous System 2001, 6: 64-64. DOI: 10.1046/j.1529-8027.2001.01008-15.x.
- Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple SclerosisGausling R, Trollmo C, Hafler D. Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple Sclerosis. Clinical Immunology 2001, 98: 11-17. PMID: 11141321, DOI: 10.1006/clim.2000.4942.
- Heterophile Antibodies Indicate Progression of Autoimmunity in Human Type 1 Diabetes Mellitus Before Clinical OnsetOrban T, Kent SC, Malik P, Milner JD, Schuster K, Jackson RA, Hafler DA. Heterophile Antibodies Indicate Progression of Autoimmunity in Human Type 1 Diabetes Mellitus Before Clinical Onset. Autoimmunity 2001, 34: 247-264. PMID: 11905851, DOI: 10.3109/08916930109014694.
- Immune Tolerance and the Nervous SystemAnderson D, Hafler D. Immune Tolerance and the Nervous System. 2001, 490: 79-98. PMID: 11505978, DOI: 10.1007/978-1-4615-1243-1_9.
- Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer AcetateDuda P, Krieger J, Schmied M, Balentine C, Hafler D. Human and Murine CD4 T Cell Reactivity to a Complex Antigen: Recognition of the Synthetic Random Polypeptide Glatiramer Acetate. The Journal Of Immunology 2000, 165: 7300-7307. PMID: 11120865, DOI: 10.4049/jimmunol.165.12.7300.
- Antigen-specific therapy for autoimmune diseaseHarrison L, Hafler D. Antigen-specific therapy for autoimmune disease. Current Opinion In Immunology 2000, 12: 704-711. PMID: 11102776, DOI: 10.1016/s0952-7915(00)00166-7.
- Examination of CD8+ T Cell Function in Humans Using MHC Class I Tetramers: Similar Cytotoxicity but Variable Proliferation and Cytokine Production Among Different Clonal CD8+ T Cells Specific to a Single Viral EpitopeLim D, Bourcier K, Freeman G, Hafler D. Examination of CD8+ T Cell Function in Humans Using MHC Class I Tetramers: Similar Cytotoxicity but Variable Proliferation and Cytokine Production Among Different Clonal CD8+ T Cells Specific to a Single Viral Epitope. The Journal Of Immunology 2000, 165: 6214-6220. PMID: 11086055, DOI: 10.4049/jimmunol.165.11.6214.
- Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramersMeyer A, Trollmo C, Crawford F, Marrack P, Steere A, Huber B, Kappler J, Hafler D. Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11433-11438. PMID: 11005833, PMCID: PMC17217, DOI: 10.1073/pnas.190335897.
- Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsiesKiefer R, Dangond F, Mueller M, Toyka KV, Hafler DA, Hartung HP. Enhanced B7 costimulatory molecule expression in inflammatory human sural nerve biopsies. Journal Of Neurology Neurosurgery & Psychiatry 2000, 69: 362. PMID: 10945811, PMCID: PMC1737105, DOI: 10.1136/jnnp.69.3.362.
- Ubiquitous pathogens: links between infection and autoimmunity in MS?Hunter S, Hafler D. Ubiquitous pathogens: links between infection and autoimmunity in MS? Neurology 2000, 55: 164-5. PMID: 10908883, DOI: 10.1212/wnl.55.2.164.
- A novel population of B7‐1+ T cells producing intracellular IL‐4 is decreased in patients with multiple sclerosisKipp B, Bar‐Or A, Gausling R, Oliveira E, Fruhan S, Stuart W, Hafler D. A novel population of B7‐1+ T cells producing intracellular IL‐4 is decreased in patients with multiple sclerosis. European Journal Of Immunology 2000, 30: 2092-2100. PMID: 10940899, DOI: 10.1002/1521-4141(200007)30:7<2092::aid-immu2092>3.0.co;2-7.
- Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetesWilson S, Kent S, Horton H, Hill A, Bollyky P, Hafler D, Strominger J, Byrne M. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 7411-7416. PMID: 10840051, PMCID: PMC16559, DOI: 10.1073/pnas.120161297.
- Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosisDuda PW, Schmied MC, Cook SL, Krieger JI, Hafler DA. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. Journal Of Clinical Investigation 2000, 105: 967-976. PMID: 10749576, PMCID: PMC377485, DOI: 10.1172/jci8970.
- Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell populationAnderson D, Bieganowska K, Bar-Or A, Oliveira E, Carreno B, Collins M, Hafler D. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. Nature Medicine 2000, 6: 211-214. PMID: 10655112, DOI: 10.1038/72323.
- Treatment of progressive multiple sclerosis with pulse cyclophosphamidel methylprednisolone: Response to therapy is linked to the duration of progressive diseaseHohol M, Olek M, Orav E, Stazzone L, Hafler D, Khoury S, Dawson D, Weiner H. Treatment of progressive multiple sclerosis with pulse cyclophosphamidel methylprednisolone: Response to therapy is linked to the duration of progressive disease. Multiple Sclerosis Journal 1999, 5: 403-409. PMID: 10618696, DOI: 10.1177/135245859900500i606.
- Autoimmunity: What is the turning point? Editorial overviewFlavell R, Hafler D. Autoimmunity: What is the turning point? Editorial overview. Current Opinion In Immunology 1999, 11: 635-637. PMID: 10631547, DOI: 10.1016/s0952-7915(99)00029-1.
- The B7–CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous systemAnderson D, Sharpe A, Hafler D. The B7–CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion In Immunology 1999, 11: 677-683. PMID: 10631554, DOI: 10.1016/s0952-7915(99)00036-9.
- Molecular pathogenesis of multiple sclerosisBar-Or A, Oliveira E, Anderson D, Hafler D. Molecular pathogenesis of multiple sclerosis. Journal Of Neuroimmunology 1999, 100: 252-259. PMID: 10695735, DOI: 10.1016/s0165-5728(99)00193-9.
- Noncanonical Vα24JαQ T cells with conservative α chain CDR3 region amino acid substitutions are restricted by CD1dKent S, Hafler D, Strominger J, Wilson S. Noncanonical Vα24JαQ T cells with conservative α chain CDR3 region amino acid substitutions are restricted by CD1d. Human Immunology 1999, 60: 1080-1089. PMID: 10600006, DOI: 10.1016/s0198-8859(99)00109-3.
- Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone.Milner J, Kent S, Ashley T, Wilson S, Strominger J, Hafler D. Differential responses of invariant V alpha 24J alpha Q T cells and MHC class II-restricted CD4+ T cells to dexamethasone. The Journal Of Immunology 1999, 163: 2522-9. PMID: 10452989, DOI: 10.4049/jimmunol.163.5.2522.
- The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosisHafler DA. The distinction blurs between an autoimmune versus microbial hypothesis in multiple sclerosis. Journal Of Clinical Investigation 1999, 104: 527-529. PMID: 10487765, PMCID: PMC483283, DOI: 10.1172/jci8193.
- Heterophile antibodies segregate in families and are associated with protection from type 1 diabetesShe J, Ellis T, Wilson S, Wasserfall C, Marron M, Reimsneider S, Kent S, Hafler D, Neuberg D, Muir A, Strominger J, Atkinson M. Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8116-8119. PMID: 10393957, PMCID: PMC22197, DOI: 10.1073/pnas.96.14.8116.
- T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy SubjectsSemana G, Gausling R, Jackson R, Hafler D. T cell Autoreactivity to Proinsulin Epitopes in Diabetic Patients and Healthy Subjects. Journal Of Autoimmunity 1999, 12: 259-267. PMID: 10330297, DOI: 10.1006/jaut.1999.0282.
- Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: Response to therapy is linked to the duration of progressive diseaseHohol M, Olek M, John Orav E, Stazzone L, Hafler D, Khoury S, Dawson D, Weiner H. Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: Response to therapy is linked to the duration of progressive disease. Multiple Sclerosis Journal 1999, 5: 403-409. DOI: 10.1191/135245899678846492.
- Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetesWilson S, Kent S, Patton K, Orban T, Jackson R, Exley M, Porcelli S, Schatz D, Atkinson M, Balk S, Strominger J, Hafler D. Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 1999, 399: 84-84. DOI: 10.1038/20007.
- HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-βSmith D, Buckle G, Hafler D, Frank D, Höllsberg P. HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-β. Virology 1999, 257: 314-321. PMID: 10329542, DOI: 10.1006/viro.1999.9679.
- Cross-Reactivity of Borrelia burgdorferi and Myelin Basic Protein-Specific T Cells Is Not Observed in Borrelial EncephalomyelitisPohl-Koppe A, Logigian E, Steere A, Hafler D. Cross-Reactivity of Borrelia burgdorferi and Myelin Basic Protein-Specific T Cells Is Not Observed in Borrelial Encephalomyelitis. Cellular Immunology 1999, 194: 118-123. PMID: 10357888, DOI: 10.1006/cimm.1999.1495.
- Cross-Reactivity of T-Cell Clones Specific for Altered Peptide Ligands of Myelin Basic ProteinAusubel L, Bieganowska K, Hafler D. Cross-Reactivity of T-Cell Clones Specific for Altered Peptide Ligands of Myelin Basic Protein. Cellular Immunology 1999, 193: 99-107. PMID: 10202117, DOI: 10.1006/cimm.1998.1447.
- Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy.Bieganowska K, Höllsberg P, Buckle G, Lim D, Greten T, Schneck J, Altman J, Jacobson S, Ledis S, Hanchard B, Chin J, Morgan O, Roth P, Hafler D. Direct analysis of viral-specific CD8+ T cells with soluble HLA-A2/Tax11-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. The Journal Of Immunology 1999, 162: 1765-71. PMID: 9973440, DOI: 10.4049/jimmunol.162.3.1765.
- T helper cell differentiation in multiple sclerosis and autoimmunityMartin R, Ruddle N, Reingold S, Hafler D. T helper cell differentiation in multiple sclerosis and autoimmunity. Trends In Immunology 1998, 19: 495-498. PMID: 9818541, DOI: 10.1016/s0167-5699(98)01345-0.
- Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosisWindhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. Journal Of Neuroimmunology 1998, 91: 1-9. PMID: 9846813, DOI: 10.1016/s0165-5728(98)00086-1.
- Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitisPohl-Koppe A, Burchett S, Thiele E, Hafler D. Myelin basic protein reactive Th2 T cells are found in acute disseminated encephalomyelitis. Journal Of Neuroimmunology 1998, 91: 19-27. PMID: 9846815, DOI: 10.1016/s0165-5728(98)00125-8.
- Increased expression of CDIIb (mac-1) on CD8+ T cells in patients with HAM/TSPBuckle G, Batra V, Hafler D, Hollsberg P. Increased expression of CDIIb (mac-1) on CD8+ T cells in patients with HAM/TSP. Journal Of Neuroimmunology 1998, 90: 64. DOI: 10.1016/s0165-5728(98)91559-4.
- Decreases in IL-4 secretion by invariant Vα24JαQT cells in peripheral blood of patients with multiple sclerosis (MS)Gausling R, Trollmo T, Hafler D. Decreases in IL-4 secretion by invariant Vα24JαQT cells in peripheral blood of patients with multiple sclerosis (MS). Journal Of Neuroimmunology 1998, 90: 72. DOI: 10.1016/s0165-5728(98)91612-5.
- CTLA4 engagement can have both positive and negative effects on human T cell activationAnderson D, Bieganowska K, Bar-Or A, Hafler D. CTLA4 engagement can have both positive and negative effects on human T cell activation. Journal Of Neuroimmunology 1998, 90: 14. DOI: 10.1016/s0165-5728(98)91262-0.
- Effect of CD28/CTLA4 signaling on function of MBP reactive T cellsBieganowska K, Anderson D, Bar-Or A, Hafler D. Effect of CD28/CTLA4 signaling on function of MBP reactive T cells. Journal Of Neuroimmunology 1998, 90: 15. DOI: 10.1016/s0165-5728(98)91267-x.
- CTLA4 blockade enhances B7-2 dependent Th-2 cytokine production from human MBP-reactive T-cellsBar-Or A, Anderson D, Bieganowska K, Hafler D. CTLA4 blockade enhances B7-2 dependent Th-2 cytokine production from human MBP-reactive T-cells. Journal Of Neuroimmunology 1998, 90: 14. DOI: 10.1016/s0165-5728(98)91263-2.
- In vitro analysis of T-cell responses to Copaxone®Duda P, Krieger J, Hafler D. In vitro analysis of T-cell responses to Copaxone®. Journal Of Neuroimmunology 1998, 90: 96. DOI: 10.1016/s0165-5728(98)91756-8.
- Pulse Cyclophosphamide Plus Methylprednisolone Induces Myelin-Antigen-Specific IL-4-Secreting T Cells in Multiple Sclerosis PatientsTakashima H, Smith D, Fukaura H, Khoury S, Hafler D, Weiner H. Pulse Cyclophosphamide Plus Methylprednisolone Induces Myelin-Antigen-Specific IL-4-Secreting T Cells in Multiple Sclerosis Patients. Clinical Immunology 1998, 88: 28-34. PMID: 9683547, DOI: 10.1006/clin.1998.4558.
- Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cellsMandelboim O, Kent S, Davis D, Wilson S, Okazaki T, Jackson R, Hafler D, Strominger J. Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 3798-3803. PMID: 9520447, PMCID: PMC19917, DOI: 10.1073/pnas.95.7.3798.
- Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.Pohl-Koppe A, Balashov K, Steere A, Logigian E, Hafler D. Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection. The Journal Of Immunology 1998, 160: 1804-10. PMID: 9469440, DOI: 10.4049/jimmunol.160.4.1804.
- Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation.Scholz C, Patton K, Anderson D, Freeman G, Hafler D. Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. The Journal Of Immunology 1998, 160: 1532-8. PMID: 9570577, DOI: 10.4049/jimmunol.160.3.1532.
- Differential Display Cloning of a Novel Human Histone Deacetylase (HDAC3) cDNA from PHA-Activated Immune CellsDangond F, Hafler D, Tong J, Randall J, Kojima R, Utku N, Gullans S. Differential Display Cloning of a Novel Human Histone Deacetylase (HDAC3) cDNA from PHA-Activated Immune Cells. Biochemical And Biophysical Research Communications 1998, 242: 648-652. PMID: 9464271, DOI: 10.1006/bbrc.1997.8033.
- Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetesWilson S, Kent S, Patton K, Orban T, Jackson R, Exley M, Porcelli S, Schatz D, Atkinson M, Balk S, Strominger J, Hafler D. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 1998, 391: 177-181. PMID: 9428763, DOI: 10.1038/34419.
- Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple SclerosisaHAFLER D, KENT S, PIETRUSEWICZ M, KHOURY S, WEINER H, FUKAURA H. Oral Administration of Myelin Induces Antigen‐specific TGF‐β1 Secreting T Cells in Patients with Multiple Sclerosisa. Annals Of The New York Academy Of Sciences 1997, 835: 120-131. PMID: 9616767, DOI: 10.1111/j.1749-6632.1997.tb48623.x.
- Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4.Höllsberg P, Scholz C, Anderson DE, Greenfield EA, Kuchroo VK, Freeman GJ, Hafler DA. Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4. The Journal Of Immunology 1997, 159: 4799-805. PMID: 9366404, DOI: 10.4049/jimmunol.159.10.4799.
- Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P, Hafler DA. Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. The Journal Of Immunology 1997, 159: 4943-51. PMID: 9366420, DOI: 10.4049/jimmunol.159.10.4943.
- Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99.Ausubel LJ, Krieger JI, Hafler DA. Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99. The Journal Of Immunology 1997, 159: 2502-12. PMID: 9278344, DOI: 10.4049/jimmunol.159.5.2502.
- Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin‐4 production and associated eosinophiliaSmith D, Balashov K, Hafler D, Khoury S, Weiner H. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: Increased interleukin‐4 production and associated eosinophilia. Annals Of Neurology 1997, 42: 313-318. PMID: 9307252, DOI: 10.1002/ana.410420307.
- Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones.Anderson DE, Ausubel LJ, Krieger J, Höllsberg P, Freeman GJ, Hafler DA. Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones. The Journal Of Immunology 1997, 159: 1669-75. PMID: 9257827, DOI: 10.4049/jimmunol.159.4.1669.
- Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunityDangond F, Windhagen A, Groves C, Hafler D. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. Journal Of Neuroimmunology 1997, 76: 132-138. PMID: 9184642, DOI: 10.1016/s0165-5728(97)00043-x.
- Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune DiseaseBieganowska K, Ausubel L, Modabber Y, Slovik E, Messersmith W, Hafler D. Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease. Journal Of Experimental Medicine 1997, 185: 1585-1594. PMID: 9151896, PMCID: PMC2196290, DOI: 10.1084/jem.185.9.1585.
- Variable Immortalizing Potential and Frequent Virus Latency in Blood-Derived T-Cell Clones Infected With Human T-Cell Leukemia Virus Type IRichardson JH, Höllsberg P, Windhagen A, Child LA, Hafler DA, Lever A. Variable Immortalizing Potential and Frequent Virus Latency in Blood-Derived T-Cell Clones Infected With Human T-Cell Leukemia Virus Type I. Blood 1997, 89: 3303-3314. PMID: 9129036, DOI: 10.1182/blood.v89.9.3303.
- Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked TrialNussenblatt R, Gery I, Weiner H, Ferris F, Shiloach J, Remaley N, Perry C, Caspi R, Hafler D, Foster C, Whitcup S. Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial. American Journal Of Ophthalmology 1997, 123: 583-592. PMID: 9152063, DOI: 10.1016/s0002-9394(14)71070-0.
- Oral Administration of Myelin Induces Antigen‐specific TGF‐β1‐secreting T Cells in Multiple Sclerosis PatientsaKENT S, FUKAURA H, PIETRUSEWICZ M, KHOURY S, WEINER H, HAFLER D. Oral Administration of Myelin Induces Antigen‐specific TGF‐β1‐secreting T Cells in Multiple Sclerosis Patientsa. Annals Of The New York Academy Of Sciences 1997, 815: 412-422. PMID: 9186687, DOI: 10.1111/j.1749-6632.1997.tb52092.x.
- B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors.Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. The Journal Of Immunology 1997, 158: 2025-34. PMID: 9036945, DOI: 10.4049/jimmunol.158.5.2025.
- Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligandBalashov K, Smith D, Khoury S, Hafler D, Weiner H. Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 599-603. PMID: 9012830, PMCID: PMC19559, DOI: 10.1073/pnas.94.2.599.
- Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clonesAusubel L, Kwan C, Sette A, Kuchroo V, Hafler D. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 15317-15322. PMID: 8986809, PMCID: PMC26402, DOI: 10.1073/pnas.93.26.15317.
- Induction of anergy in CD8 T cells by B cell presentation of antigen.Höllsberg P, Batra V, Dressel A, Hafler DA. Induction of anergy in CD8 T cells by B cell presentation of antigen. The Journal Of Immunology 1996, 157: 5269-76. PMID: 8955172, DOI: 10.4049/jimmunol.157.12.5269.
- Autoimmunity How to know thy selfHafler D, Flavell R. Autoimmunity How to know thy self. Current Opinion In Immunology 1996, 8: 805-807. PMID: 8994859, DOI: 10.1016/s0952-7915(96)80008-2.
- Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligandWeiner H, Balashov K, Smith D, Khoury S, Hafler D. Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ T cells via CD40 ligand. Multiple Sclerosis Journal 1996, 2: 253-253. DOI: 10.1177/135245859600200519.
- Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation.Scholz C, Freeman GJ, Greenfield EA, Hafler DA, Höllsberg P. Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. The Journal Of Immunology 1996, 157: 2932-8. PMID: 8816399, DOI: 10.4049/jimmunol.157.7.2932.
- Downregulation of IL‐10 secretion and enhanced antigen‐presenting abilities following HTLV‐I infection of T cellsScholz C, Hafler DA, Höllsberg P. Downregulation of IL‐10 secretion and enhanced antigen‐presenting abilities following HTLV‐I infection of T cells. Journal Of Neuroscience Research 1996, 45: 786-794. PMID: 8892090, DOI: 10.1002/(sici)1097-4547(19960915)45:6<786::aid-jnr15>3.0.co;2-u.
- Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative DisorderRothenberg M, Weber W, Longtine J, Hafler D. Cytotoxic γδ T Lymphocytes Associated with an Epstein–Barr Virus-Induced Posttransplantation Lymphoproliferative Disorder. Clinical Immunology 1996, 80: 266-272. PMID: 8811046, DOI: 10.1006/clin.1996.0122.
- Functional Characterization of Autoreactive T-cells in Acute Disseminated Encephalomyelitis 199Pohi-Koppe A, Burchett S, Hafler D. Functional Characterization of Autoreactive T-cells in Acute Disseminated Encephalomyelitis 199. Pediatric Research 1996, 40: 548-548. DOI: 10.1203/00006450-199609000-00222.
- IL-12 induces human T cells secreting IL-10 with IFN-gamma.Windhagen A, Anderson DE, Carrizosa A, Williams RE, Hafler DA. IL-12 induces human T cells secreting IL-10 with IFN-gamma. The Journal Of Immunology 1996, 157: 1127-31. PMID: 8757617, DOI: 10.4049/jimmunol.157.3.1127.
- Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. Journal Of Clinical Investigation 1996, 98: 70-77. PMID: 8690806, PMCID: PMC507402, DOI: 10.1172/jci118779.
- TCR usage in human and experimental demyelinating diseaseHafler D, Saadeh M, Kuchroo V, Milford E, Steinman L. TCR usage in human and experimental demyelinating disease. Trends In Immunology 1996, 17: 152-159. PMID: 8871344, DOI: 10.1016/0167-5699(96)80611-6.
- Role of Th1 and Th2 Cells in Neurologie DisordersWindhagen A, Nicholson L, Weiner H, Kuchroo V, Hafler D. Role of Th1 and Th2 Cells in Neurologie Disorders. 1996, 63: 171-186. DOI: 10.1159/000319485.
- Pilot Study of Oral Tolerance to Keyhole Limpet Hemocyanin in Humans.MATSUI M, HAFLER D, WEINER H. Pilot Study of Oral Tolerance to Keyhole Limpet Hemocyanin in Humans. Annals Of The New York Academy Of Sciences 1996, 778: 398-404. PMID: 8611003, DOI: 10.1111/j.1749-6632.1996.tb21156.x.
- Three‐year Open Protocol Continuation Study of Oral Tolerization with Myelin Antigens in Multiple Sclerosis and Design of a Phase III Pivotal TrialHOHOL M, KHOURY S, COOK S, ORAV E, HAFLER D, WEINER H. Three‐year Open Protocol Continuation Study of Oral Tolerization with Myelin Antigens in Multiple Sclerosis and Design of a Phase III Pivotal Trial. Annals Of The New York Academy Of Sciences 1996, 778: 243-250. PMID: 8610977, DOI: 10.1111/j.1749-6632.1996.tb21132.x.
- Antigen‐specific TGF‐β1 Secretion with Bovine Myelin Oral Tolerization in Multiple SclerosisFUKAURA H, KENT S, PIETRUSEWICZ M, KHOURY S, WEINER H, HAFLER D. Antigen‐specific TGF‐β1 Secretion with Bovine Myelin Oral Tolerization in Multiple Sclerosis. Annals Of The New York Academy Of Sciences 1996, 778: 251-257. PMID: 8610978, DOI: 10.1111/j.1749-6632.1996.tb21133.x.
- HTLV-I-induced T-cell activation.Buckle GJ, Hafler DA, Höllsberg P. HTLV-I-induced T-cell activation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1996, 13 Suppl 1: s107-13. PMID: 8797712, DOI: 10.1097/00042560-199600001-00018.
- Role of Th1 and Th2 Cells in Neurologic DisordersWindhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 Cells in Neurologic Disorders. 1996, 63: 171-186. PMID: 8934837, DOI: 10.1159/000425063.
- Antigen-specific therapies for the treatment of autoimmune diseasesHafler D, Weiner H. Antigen-specific therapies for the treatment of autoimmune diseases. 1996, 61-76. DOI: 10.1007/978-3-642-61191-9_6.
- Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML, Hafler DA. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. Journal Of Experimental Medicine 1995, 182: 1985-1996. PMID: 7500044, PMCID: PMC2192240, DOI: 10.1084/jem.182.6.1985.
- Case 37-1995 — A 6-year-old boy with a rash, meningismus, and diplegiaCabot R, Scully R, Mark E, McNeely W, McNeely B, Hafler D, Hedley-Whyte E. Case 37-1995 — A 6-year-old boy with a rash, meningismus, and diplegia. New England Journal Of Medicine 1995, 333: 1485-1493. PMID: 7477150, DOI: 10.1056/nejm199511303332208.
- Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes.Wucherpfennig KW, Hafler DA, Strominger JL. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 8896-8900. PMID: 7568039, PMCID: PMC41074, DOI: 10.1073/pnas.92.19.8896.
- T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans.Markovic-Plese S, Fukaura H, Zhang J, al-Sabbagh A, Southwood S, Sette A, Kuchroo VK, Hafler DA. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. The Journal Of Immunology 1995, 155: 982-92. PMID: 7541828, DOI: 10.4049/jimmunol.155.2.982.
- A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein PeptideaWUCHERPFENNIG K, HAFLER D. A Review of T‐Cell Receptors in Multiple Sclerosis: Clonal Expansion and Persistence of Human T‐Cells Specific for an Immunodominant Myelin Basic Protein Peptidea. Annals Of The New York Academy Of Sciences 1995, 756: 241-258. PMID: 7544075, DOI: 10.1111/j.1749-6632.1995.tb44522.x.
- Antigen-specific therapies for the treatment of autoimmune diseasesHafler D, Weiner H. Antigen-specific therapies for the treatment of autoimmune diseases. Seminars In Immunopathology 1995, 17: 61-76. PMID: 7482227, DOI: 10.1007/bf00194100.
- Correlation of Magnetic Resonance Imaging With Immune and Clinical Measures in 45 MS Patients Receiving 20 to 24 MRI Scans Each Over a 1 -Year Period: 1Weiner H, Guttman C, Khoury S, Hohol M, Hafler D, Orav E, Hsu L, Ahn S, Kikinis R, Jolesz F. Correlation of Magnetic Resonance Imaging With Immune and Clinical Measures in 45 MS Patients Receiving 20 to 24 MRI Scans Each Over a 1 -Year Period: 1. Neurology 1995, 45: 1416-1416. DOI: 10.1212/wnl.45.7.1416.
- Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis.Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. Journal Of Clinical Investigation 1995, 95: 2711-2719. PMID: 7769110, PMCID: PMC295954, DOI: 10.1172/jci117973.
- Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements.Stinissen P, Vandevyver C, Medaer R, Vandegaer L, Nies J, Tuyls L, Hafler DA, Raus J, Zhang J. Increased frequency of gamma delta T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. The Journal Of Immunology 1995, 154: 4883-94. PMID: 7722338, DOI: 10.4049/jimmunol.154.9.4883.
- Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.Höllsberg P, Weber WE, Dangond F, Batra V, Sette A, Hafler DA. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4036-4040. PMID: 7732026, PMCID: PMC42097, DOI: 10.1073/pnas.92.9.4036.
- Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligandWindhagen A, Schooz C, Höllsberg P, Fukaura H, Sette A, Hafler D. Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand. Immunity 1995, 2: 373-380. PMID: 7536622, DOI: 10.1016/1074-7613(95)90145-0.
- Immunologic Mechanisms and Therapy in Multiple SclerosisHAFLER D, WEINER H. Immunologic Mechanisms and Therapy in Multiple Sclerosis. Immunological Reviews 1995, 144: 75-107. PMID: 7590822, DOI: 10.1111/j.1600-065x.1995.tb00066.x.
- Tropical spastic paraparesis on the Caribbean coast of Colombia.Dangond F, Daza JS, Rosania A, Quin MJ, Zaninovic V, Chaplin B, Marlink R, Hafler DA. Tropical spastic paraparesis on the Caribbean coast of Colombia. American Journal Of Tropical Medicine And Hygiene 1995, 52: 155-8. PMID: 7872443, DOI: 10.4269/ajtmh.1995.52.155.
- Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matterMcLaurin J, Hafler D, Antel J. Reactivity of normal T-cell lines to MBP isolated from normal and multiple sclerosis white matter. Journal Of The Neurological Sciences 1995, 128: 205-211. PMID: 7537795, DOI: 10.1016/0022-510x(94)00224-c.
- Therapy for Multiple SclerosisWeiner H, Hohol M, Khoury S, Dawson D, Hafler D. Therapy for Multiple Sclerosis. Neurologic Clinics 1995, 13: 173-196. PMID: 7739502, DOI: 10.1016/s0733-8619(18)30066-5.
- What is the pathogenesis of human T‐cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis?Höllsberg P, Hafler D. What is the pathogenesis of human T‐cell lymphotropic virus type I–associated myelopathy/tropical spastic paraparesis? Annals Of Neurology 1995, 37: 143-145. PMID: 7847855, DOI: 10.1002/ana.410370203.
- Antigen specific therapies for the treatment of autoimmune diseases.Hafler DA, Weiner HL. Antigen specific therapies for the treatment of autoimmune diseases. 1995, 47: 59-77. PMID: 7785504, DOI: 10.1007/978-3-0348-7343-7_5.
- Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune DiseaseHafler DA, Weiner HL. Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease. 1995, 60: 126-149. PMID: 7857525, DOI: 10.1159/000423974.
- Treatment of multiple sclerosis and other autoimmune diseases by oral tolerance to autoantigensWeiner H, Hohol M, Fukaura H, Kent S, Orav J, Khoury S, Hafler D. Treatment of multiple sclerosis and other autoimmune diseases by oral tolerance to autoantigens. Journal Of Neuroimmunology 1995, 56: 14. DOI: 10.1016/0165-5728(95)98898-l.
- Modification of immune responses to myelin basic protein (MBP) using altered peptide ligandsHafler D, Windhagen A, Scholz C, Fukaura H, Höllsberg P. Modification of immune responses to myelin basic protein (MBP) using altered peptide ligands. Journal Of Neuroimmunology 1995, 56: 17. DOI: 10.1016/0165-5728(95)98910-4.
- Functional three-domain single-chain T-cell receptors.Chung S, Wucherpfennig KW, Friedman SM, Hafler DA, Strominger JL. Functional three-domain single-chain T-cell receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 12654-12658. PMID: 7809095, PMCID: PMC45497, DOI: 10.1073/pnas.91.26.12654.
- Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (Part 2 of 2)Hafler D, Weiner H. Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (Part 2 of 2). 1994, 60: 138-149. DOI: 10.1159/000319270.
- Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (Part 1 of 2)Hafler D, Weiner H. Antigen-Specific Immunosuppression: Oral Tolerance for the Treatment of Autoimmune Disease (Part 1 of 2). 1994, 60: 126-137. DOI: 10.1159/000319269.
- T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humansMarkovic-Plese S, Fukoara H, Al-Sabbagh A, Sette A, Kuchroo V, Hafler D. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans. Journal Of Neuroimmunology 1994, 54: 179. DOI: 10.1016/0165-5728(94)90423-5.
- Differential activation of cytolysis and proliferation in HTLV-I tax-reactive CD8 T cells by a single amino acid substitution in a T cell receptor contact residue of the peptide antigenHöllsberg P, Weber W, Dangond F, Batra V, Sette A, Hafler D. Differential activation of cytolysis and proliferation in HTLV-I tax-reactive CD8 T cells by a single amino acid substitution in a T cell receptor contact residue of the peptide antigen. Journal Of Neuroimmunology 1994, 54: 168. DOI: 10.1016/0165-5728(94)90360-3.
- In vivo clonal depletion of human myelin basic protein-reactive T cells by T cell vaccinationZhang J, Medaer R, Stinissen P, Hafler D, Raus J. In vivo clonal depletion of human myelin basic protein-reactive T cells by T cell vaccination. Journal Of Neuroimmunology 1994, 54: 208. DOI: 10.1016/0165-5728(94)90597-5.
- Switch of autoreactive human T cell clones from a TH2 to a TGFβ1 secreting phenotype with low affinity T-cell receptor stimulating peptide/MHC complexWindhagen A, Scholz C, Fukaura H, Sette A, Hafler D. Switch of autoreactive human T cell clones from a TH2 to a TGFβ1 secreting phenotype with low affinity T-cell receptor stimulating peptide/MHC complex. Journal Of Neuroimmunology 1994, 54: 206. DOI: 10.1016/0165-5728(94)90586-x.
- Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune EncephalomyelitisChen Y, Kuchroo V, Inobe J, Hafler D, Weiner H. Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis. Science 1994, 265: 1237-1240. PMID: 7520605, DOI: 10.1126/science.7520605.
- Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.Höllsberg P, Ausubel LJ, Hafler DA. Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression. The Journal Of Immunology 1994, 153: 566-73. PMID: 8021495, DOI: 10.4049/jimmunol.153.2.566.
- Regional specificity of HTLV-I pro viral integration in the human genomeZoubak S, Richardson JH, Rynditch A, Hollsberg P, Hafler DA, Boeri E, Lever A, Bernardi G. Regional specificity of HTLV-I pro viral integration in the human genome. Gene 1994, 143: 155-163. PMID: 8206368, DOI: 10.1016/0378-1119(94)90091-4.
- Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.Wucherpfennig KW, Zhang J, Witek C, Matsui M, Modabber Y, Ota K, Hafler DA. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. The Journal Of Immunology 1994, 152: 5581-92. PMID: 7514641, DOI: 10.4049/jimmunol.152.11.5581.
- T cell anergyLasalle J, Hafler D. T cell anergy. The FASEB Journal 1994, 8: 601-608. PMID: 8005388, DOI: 10.1096/fasebj.8.9.8005388.
- T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice.Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. Journal Of Experimental Medicine 1994, 179: 1659-1664. PMID: 8163944, PMCID: PMC2191471, DOI: 10.1084/jem.179.5.1659.
- Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of AutoantigensWeiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens. Annual Review Of Immunology 1994, 12: 809-837. PMID: 8011298, DOI: 10.1146/annurev.iy.12.040194.004113.
- Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. Journal Of Experimental Medicine 1994, 179: 973-984. PMID: 7509366, PMCID: PMC2191414, DOI: 10.1084/jem.179.3.973.
- Cyclophosphamide and MS‐RRRWeiner H, Orav E, Hafler D, Dawson D. Cyclophosphamide and MS‐RRR. Neurology 1994, 44: 580-580. DOI: 10.1212/wnl.44.3_part_1.580.
- Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.Wucherpfennig KW, Sette A, Southwood S, Oseroff C, Matsui M, Strominger JL, Hafler DA. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. Journal Of Experimental Medicine 1994, 179: 279-290. PMID: 7505801, PMCID: PMC2191316, DOI: 10.1084/jem.179.1.279.
- Effects of Oral Administration of Type II Collagen on Rheumatoid ArthritisTrentham D, Dynesius-Trentham R, Orav E, Combitchi D, Lorenzo C, Sewell K, Hafler D, Weiner H. Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis. Science 1993, 261: 1727-1730. PMID: 8378772, DOI: 10.1126/science.8378772.
- MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell VaccinationZhang J, Medaer R, Stinissen P, Hafler D, Raus J. MHC-Restricted Depletion of Human Myelin Basic Protein-Reactive T Cells by T Cell Vaccination. Science 1993, 261: 1451-1454. PMID: 7690157, DOI: 10.1126/science.7690157.
- T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen.LaSalle JM, Toneguzzo F, Saadeh M, Golan DE, Taber R, Hafler DA. T-cell presentation of antigen requires cell-to-cell contact for proliferation and anergy induction. Differential MHC requirements for superantigen and autoantigen. The Journal Of Immunology 1993, 151: 649-57. PMID: 7687620, DOI: 10.4049/jimmunol.151.2.649.
- Increased Protein Kinase C Activity in Human Memory T CellsHöllsberg P, Melinek J, Benjamin D, Hafler D. Increased Protein Kinase C Activity in Human Memory T Cells. Cellular Immunology 1993, 149: 170-179. PMID: 8099849, DOI: 10.1006/cimm.1993.1145.
- Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group.Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A, Fisher M, Birnbaum G, McArthur J, Butler R, Moore M, Sigsbee B, Safran A. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 1993, 43: 910-8. PMID: 8388090, DOI: 10.1212/wnl.43.5.910.
- Biological activity of recombinant human myelin basic proteinOettinger H, Al-Sabbagh A, Jingwu Z, LaSalle J, Weiner H, Hafler D. Biological activity of recombinant human myelin basic protein. Journal Of Neuroimmunology 1993, 44: 157-162. PMID: 7685037, DOI: 10.1016/0165-5728(93)90037-y.
- Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I InfectionFlier J, Underhill L, Hollsberg P, Hafler D. Pathogenesis of Diseases Induced by Human Lymphotropic Virus Type I Infection. New England Journal Of Medicine 1993, 328: 1173-1182. PMID: 8455685, DOI: 10.1056/nejm199304223281608.
- Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple SclerosisWeiner H, Mackin G, Matsui M, Orav E, Khoury S, Dawson D, Hafler D. Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis. Science 1993, 259: 1321-1324. PMID: 7680493, DOI: 10.1126/science.7680493.
- Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. Journal Of Experimental Medicine 1993, 177: 425-432. PMID: 8093893, PMCID: PMC2190895, DOI: 10.1084/jem.177.2.425.
- The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis.Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clinical And Experimental Rheumatology 1993, 11 Suppl 8: s39-40. PMID: 7686832.
- Suppression of Organ-Specific Autoimmune Diseases by Oral Administration of AutoantigensWeiner H, Miller A, Khoury S, Zhang Z, Al-Sabbagh A, Brod S, Lider O, Higgins P, Sobel R, Matsui M, Sayegh M, Carpenter C, Eisenbarth G, Nussenblatt R, Hafler D. Suppression of Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens. 1993, 627-634. DOI: 10.1007/978-3-642-51479-1_81.
- CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. The Journal Of Immunology 1992, 149: 3795-801. PMID: 1281186, DOI: 10.4049/jimmunol.149.12.3795.
- Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial InfarctionKrumholz H, Pasternak R, Weinstein M, Friesinger G, Ridker P, Tosteson A, Goldman L. Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial Infarction. New England Journal Of Medicine 1992, 327: 7-13. PMID: 1598117, DOI: 10.1056/nejm199207023270102.
- Early signaling defects in human T cells anergized by T cell presentation of autoantigen.LaSalle JM, Tolentino PJ, Freeman GJ, Nadler LM, Hafler DA. Early signaling defects in human T cells anergized by T cell presentation of autoantigen. Journal Of Experimental Medicine 1992, 176: 177-186. PMID: 1535366, PMCID: PMC2119294, DOI: 10.1084/jem.176.1.177.
- Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. The Journal Of Immunology 1992, 148: 3256-63. PMID: 1374452, DOI: 10.4049/jimmunol.148.10.3256.
- Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4588-4592. PMID: 1374907, PMCID: PMC49128, DOI: 10.1073/pnas.89.10.4588.
- T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. Journal Of Experimental Medicine 1992, 175: 993-1002. PMID: 1348083, PMCID: PMC2119186, DOI: 10.1084/jem.175.4.993.
- T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones.Wucherpfennig KW, Höllsberg P, Richardson JH, Benjamin D, Hafler DA. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2110-2114. PMID: 1549569, PMCID: PMC48606, DOI: 10.1073/pnas.89.6.2110.
- T cell vaccination in multiple sclerosis: A preliminary reportHafler D, Cohen I, Benjamin D, Weiner H. T cell vaccination in multiple sclerosis: A preliminary report. Clinical Immunology 1992, 62: 307-313. PMID: 1541056, DOI: 10.1016/0090-1229(92)90108-z.
- Immunotherapy in autoimmune diseasesMiller A, Hafler D, Weiner H. Immunotherapy in autoimmune diseases. Current Biology 1992, 2: 74. DOI: 10.1016/0960-9822(92)90205-o.
- Autoreactive T Cells in Multiple SclerosisZhang J, Weiner H, Hafler D. Autoreactive T Cells in Multiple Sclerosis. International Reviews Of Immunology 1992, 9: 183-201. PMID: 1285060, DOI: 10.3109/08830189209061790.
- Experimental Approaches to Specific Immunotherapy in Multiple SclerosisHafler D, Brod S, Weiner H. Experimental Approaches to Specific Immunotherapy in Multiple Sclerosis. 1992, 301-307. DOI: 10.1007/978-1-4471-3184-7_15.
- Treatment of Multiple Sclerosis with CyclophosphamideMackin G, Dawson D, Hafler D, Weiner H. Treatment of Multiple Sclerosis with Cyclophosphamide. 1992, 199-216. DOI: 10.1007/978-1-4471-3184-7_9.
- The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple SclerosisHAFLER D, MATSUI M, WUCHERPFENNIG K, OTA K, WEINER H. The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis. Annals Of The New York Academy Of Sciences 1991, 636: 251-265. PMID: 1724362, DOI: 10.1111/j.1749-6632.1991.tb33456.x.
- Immunotherapy in autoimmune diseasesMiller A, Hafler D, Weiner H. Immunotherapy in autoimmune diseases. Current Opinion In Immunology 1991, 3: 936-940. PMID: 1793539, DOI: 10.1016/s0952-7915(05)80017-2.
- Antigen‐Driven Peripheral Immune ToleranceWEINER H, ZHANG Z, KHOURY S, MILLER A, AL‐SABBAGH A, BROD S, LIDER O, HIGGINS P, SOBEL R, NUSSENBLATT R, HAFLER D. Antigen‐Driven Peripheral Immune Tolerance. Annals Of The New York Academy Of Sciences 1991, 636: 227-232. PMID: 1793212, DOI: 10.1111/j.1749-6632.1991.tb33454.x.
- The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycleLaSalle J, Hafler D. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology 1991, 138: 197-206. PMID: 1833074, DOI: 10.1016/0008-8749(91)90144-z.
- ReplyHafler D, Wucherpfennig K, Brod S, Weiner H. Reply. Annals Of Neurology 1991, 30: 624-624. DOI: 10.1002/ana.410300422.
- Presentation of autoantigen by human T cells.LaSalle JM, Ota K, Hafler DA. Presentation of autoantigen by human T cells. The Journal Of Immunology 1991, 147: 774-80. PMID: 1713605, DOI: 10.4049/jimmunol.147.3.774.
- Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.Brod SA, Benjamin D, Hafler DA. Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease. The Journal Of Immunology 1991, 147: 810-5. PMID: 1907306, DOI: 10.4049/jimmunol.147.3.810.
- T-cell recognition of myelin basic proteinWucherpfennig K, Weiner H, Hafler D. T-cell recognition of myelin basic protein. Trends In Immunology 1991, 12: 277-282. PMID: 1716903, DOI: 10.1016/0167-5699(91)90126-e.
- Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseasesMiller A, Hafler D, Weiner H. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. The FASEB Journal 1991, 5: 2560-2566. PMID: 1868980, DOI: 10.1096/fasebj.5.11.1868980.