Emanuela Bruscia, PhD
Cards
About
Titles
Associate Professor of Pediatrics (Respiratory)
Biography
Dr. Bruscia received her Ph.D. in Biochemistry and Molecular Genetics from the University of Tor Vergata in Rome (Italy) in 2002. Since she was an undergraduate, her research has been dedicated to Cystic Fibrosis. During her undergraduate studies, she began working in the exciting field of gene therapy. She spent two years in the laboratory of Dr. Dieter Gruenert at the University of Vermont (Burlington, VT), where she worked on non-viral gene therapy strategies. She started her postdoctoral training in the laboratory of Dr. Diane Krause at Yale School of Medicine in 2002. Here, she explored the use of bone marrow-derived cells as a vehicle for gene therapy in the airway and intestinal epithelia in murine models for CF. In 2005, Dr. Bruscia was appointed as an Associate Research Scientist in the Department of Pediatrics at Yale School of Medicine and in 2010 promoted as an Assistant Professor in the same department. In 2016, she was promoted to Associate Professor. In the past ten years, her research interest has focused on the role of CFTR in the immune system, particularly in macrophages. The current focus of her lab is to explore emerging therapeutic strategies able to target several aspects of CF lung disease, while still proceeding with studies focused on understanding how the lack of CFTR is impairing macrophage function.
Appointments
Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
Associate Professor on TermPrimary
Other Departments & Organizations
- Bruscia Lab
- Center for Infection and Immunity
- CPIRT - Center for Pulmonary Injury, Inflammation, Repair and Therapeutics
- Molecular Medicine, Pharmacology, and Physiology
- Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine
- Pediatrics
- Program in Translational Biomedicine (PTB)
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Stem Cell Center
- Yale Ventures
- YCCEH
Education & Training
- PhD
- Tor Vergata University in Rome (2002)
Research
Links & Media
Media
Cystic Fibrosis and dysregulated immune response
We investigate the mechanism/s by which the dysregulated activity of immune cells contributes to the overwhelming lung inflammation, the weakened host defense against certain microorganisms, and the altered lung tissue repair processes that characterize CF lung disease.