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INFORMATION FOR

Thomas M. Gill, MD

Humana Foundation Professor of Medicine (Geriatrics) and Professor of Epidemiology (Chronic Diseases) and of Investigative Medicine; Director, Yale Program on Aging; Director, Claude D. Pepper Older Americans Independence Center; Director, Yale Center for Disability and Disabling Disorders; Director, Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research

Research Summary

Dr. Gill's research is directed towards understanding the mechanisms underlying the development of functional decline and disability among community-living older persons and towards developing preventive strategies to forestall the onset and progression of disability among those who are most vulnerable. The results from the Yale Precipitating Events Project (PEP), Dr. Gill's ongoing NIA-funded cohort study, which includes monthly assessments of functional status for over 24 years, are revolutionizing our understanding of disability, a problem of immense importance to older persons, their families, and society. In a landmark clinical trial, Dr. Gill's research group demonstrated that functional decline among frail older persons can be prevented through a prehabilitation program targeting underlying impairments in physical capabilities.

Extensive Research Description

Dr. Gill's research is directed towards understanding the mechanisms underlying the development of functional decline and disability among community-living older persons and towards developing preventive strategies to forestall the onset and progression of disability among those who are most vulnerable. The results from the Yale Precipitating Events Project (PEP), Dr. Gill's ongoing NIA-funded cohort study, which includes monthly assessments of functional status for over 24 years, are revolutionizing our understanding of disability, a problem of immense importance to older persons,their families, and society. In a landmark clinical trial, Dr. Gill's research group demonstrated that functional decline among frail older persons can be prevented through a prehabilitation program targeting underlying impairments in physical capabilities. He has led and/or played major roles on many multi-site clinical trials, including an ongoing multi-site pragmatic trial that is comparing clinical outcomes and health care utilization of a health system-based dementia care program, a community-based dementia care program, and usual care. He has recently established a working group in the medical school on translational geroscience, which includes an annual pilot grant program and visiting professorship.

Dr. Gill directs the Center on Disability and Disabling Disorders, which conducts longitudinal studies and clinical trials to enhance the scientific knowledge base of the disablement process and to rigorously evaluate promising intervention strategies. The Center includes an expanding number of clinical investigators, across disciplines, who are pursuing aging research related to disability and disabling disorders. This includes functional assessment in general as well as the functional consequences of highly prevalent disease-specific conditions such as arthritis, heart failure, chronic obstructive pulmonary disease (COPD), influenza, diabetes, stroke, depression, dementia, sleep deficiency, critical illness and major surgery. Under Dr. Gill's direction, the Center has acquired significant expertise with the National Health and Aging Trends Study (NHATS), an ongoing, nationally representative longitudinal study of 7,600+ community-living persons aged 65 years or older, which is serving as a primary data source for several projects related to the epidemiology of disability, including a newly funded R01 from the National Institute of Minority Health and Health Disparities: "A Multifactorial Approach to Evaluating Disparities in Outcomes after Major Surgery in Disadvantaged Older Persons".


1. Yale PEP Study: Epidemiology of Disability and Recovery in Older Persons

2. NHATS: A Multifactorial Approach to Evaluating Disparities in Outcomes after Major Surgery in Disadvantaged Older Persons

3. Yale PEP Study: Distressing Symptoms and Disability Before and After Sentinel Health Events among Community-living Older Persons

Coauthors

Research Interests

Aging; Disability Evaluation; Epidemiology; Geriatrics; General Surgery; Geriatric Assessment; Clinical Trial; Health Status Disparities; Geroscience

Public Health Interests

Aging; Chronic Diseases; Clinical Trials; Epidemiology Methods

Research Image

Selected Publications

  • 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older PersonsMiner B, Yaggi H, Gill T, Doyle M, Stone K, Redline S, Ensrud K, Blackwell T, Knauert M. 0321 Poor Agreement Among Self-Reported and Objective Sleep Deficiency Assessments in Older Persons Sleep 2022, 45: a144-a145. DOI: 10.1093/sleep/zsac079.319.
  • Distressing Symptoms Before and After Critical Illness Among Community-Living Older AdultsJain S, Murphy T, Gahbauer E, Leo-Summers L, Ferrante L, Gill T. Distressing Symptoms Before and After Critical Illness Among Community-Living Older Adults 2022, a2289-a2289. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2289.
  • Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) StudyFerrante L, Hajduk A, Cohen A, McAvay G, Geda M, Chattopadhyay S, Lee S, Acampora D, Gill T, Murphy T. Factors Associated with Disability Over the 6 Months After a COVID Hospitalization Among Older Adults: The VALIANT (CO V ID-19 in Older A dults: A L ong i tudinal A ssessme nt ) Study 2022, a3696-a3696. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3696.
  • Abstract 67: Observed And Genomic Life’S Simple 7 Influence Brain Health-related Neuroimaging Traits In Persons Without Stroke Or DementiaAcosta J, Both C, Rivier C, Leasure A, Gill T, Payabvash S, Sheth K, Falcone G. Abstract 67: Observed And Genomic Life’S Simple 7 Influence Brain Health-related Neuroimaging Traits In Persons Without Stroke Or Dementia Stroke 2022, 53: a67-a67. DOI: 10.1161/str.53.suppl_1.67.
  • Abstract WP178: Biological Age Influences Clinically-evident And Asymptomatic Cerebrovascular Disease: Combined Analysis In The Uk Biobank And All Of UsRivier C, Szejko N, Acosta J, Both C, Leasure A, Lopez V, Gill T, Sheth K, Falcone G. Abstract WP178: Biological Age Influences Clinically-evident And Asymptomatic Cerebrovascular Disease: Combined Analysis In The Uk Biobank And All Of Us Stroke 2022, 53: awp178-awp178. DOI: 10.1161/str.53.suppl_1.wp178.
  • Patient-Centered Digital Screener for Elder Abuse in the Emergency DepartmentAbujarad F, Choo E, Dziura J, Edwards C, Pantalon M, Jubanyik K, D'Onofrio G, Gill T. Patient-Centered Digital Screener for Elder Abuse in the Emergency Department Innovation In Aging 2021, 5: 152-152. PMCID: PMC8682507, DOI: 10.1093/geroni/igab046.580.
  • Abstract MP40: Klotho -vS Heterozygosity is Associated With Lower Risk of Lobar Intracerebral HemorrhageAcosta J, Szejko N, Both C, Leasure A, Woo D, Langefeld C, Biffi A, Anderson C, Rosand J, Gill T, Sansing L, Sheth K, Falcone G. Abstract MP40: Klotho -vS Heterozygosity is Associated With Lower Risk of Lobar Intracerebral Hemorrhage Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp40.
  • Perceived Value of Using a Digital Tool to Screen for Elder Mistreatment in the Emergency DepartmentAbujarad F, Gill T, Pantalon M, Jubanyik K, Dziura J, D’Onofrio G, Choo E. Perceived Value of Using a Digital Tool to Screen for Elder Mistreatment in the Emergency Department Innovation In Aging 2020, 4: 195-195. PMCID: PMC7740753, DOI: 10.1093/geroni/igaa057.631.
  • Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older AdultsSpeiser J, Callahan K, Fanning J, Gill T, Newman A, Pahor M, Rejeski J, Houston D. Machine Learning in Aging: An Example of Developing Prediction Models for Serious Fall Injury in Older Adults Innovation In Aging 2020, 4: 268-269. PMCID: PMC7740828, DOI: 10.1093/geroni/igaa057.859.
  • Digital Health Tool to Assist Older Adults in Self-Disclosing Elder MistreatmentAbujarad F, Choo E, Pantalon M, Jubanyik K, Dziura J, Edwards C, D’Onofrio G, Gill T. Digital Health Tool to Assist Older Adults in Self-Disclosing Elder Mistreatment Innovation In Aging 2020, 4: 755-756. PMCID: PMC7743726, DOI: 10.1093/geroni/igaa057.2724.
  • 404 Emergency Department Tablet-Based Screening Tool for Elder AbuseJubanyik K, Choo E, Pantalon M, Dziura J, Edwards C, Gill T, D'Onofrio G, Abujarad F. 404 Emergency Department Tablet-Based Screening Tool for Elder Abuse Annals Of Emergency Medicine 2020, 76: s154. DOI: 10.1016/j.annemergmed.2020.09.420.
  • 380-P: Hypoglycemia among Nursing Home Residents with Diabetes Detected by Continuous Glucose Monitoring (CGM)LIPSKA K, DOYLE M, CENGIZ E, DROZDOWICZ B, GILL T, MURPHY T, INZUCCHI S. 380-P: Hypoglycemia among Nursing Home Residents with Diabetes Detected by Continuous Glucose Monitoring (CGM) Diabetes 2020, 69 DOI: 10.2337/db20-380-p.
  • Aktivit?tseinschr?nkungen in den letzten Jahren des Lebens: Eine Frage der Todesursache?Stolz E, Gill T, Mayerl H, Freidl W. Aktivit?tseinschr?nkungen in den letzten Jahren des Lebens: Eine Frage der Todesursache? Das Gesundheitswesen 2020, 82: 457-458. DOI: 10.1055/s-0040-1708979.
  • Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid HemorrhageAcosta J, Both C, Brown S, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Matouk C, Gunel M, Gill T, Sheth K, Falcone G. Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.66.
  • Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk FactorsFalcone G, Acosta J, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Schindler J, Sansing L, Gill T, Matouk C, Gunel M, Sheth K. Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.71.
  • 55: FACTORS ASSOCIATED WITH HOME HEALTH REHABILITATION UTILIZATION AMONG OLDER ICU SURVIVORSFalvey J, Murphy T, Gill T, Stevens-Lapsley J, Ferrante L. 55: FACTORS ASSOCIATED WITH HOME HEALTH REHABILITATION UTILIZATION AMONG OLDER ICU SURVIVORS Critical Care Medicine 2020, 48: 28-28. DOI: 10.1097/01.ccm.0000618720.61285.a5.
  • ASSOCIATIONS OF GENETICS AND LIFE COURSE CIRCUMSTANCES WITH A NOVEL AGING MEASURE THAT CAPTURES MORTALITY RISKLiu Z, Chen X, Gill T, Ma C, Crimmins E, Levine M. ASSOCIATIONS OF GENETICS AND LIFE COURSE CIRCUMSTANCES WITH A NOVEL AGING MEASURE THAT CAPTURES MORTALITY RISK Innovation In Aging 2019, 3: s322-s323. PMCID: PMC6840282, DOI: 10.1093/geroni/igz038.1177.
  • SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECTMonin J, Laws H, Gahbauer E, Murphy T, Gill T. SPOUSAL ASSOCIATIONS IN MONTHLY REPORTS OF DISABILITY IN THE PRECIPITATING EVENTS PROJECT Innovation In Aging 2019, 3: s672-s672. PMCID: PMC6845752, DOI: 10.1093/geroni/igz038.2484.
  • RATINGS OF PERCEIVED EXERTION: PREDICTING MOBILITY DISABILITY AND RESPONSE TO PHYSICAL ACTIVITY IN OLDER ADULTSCenko E, Gill T, Glynn N, Pahor M, Qiu P, Valiani V, You L, Manini T. RATINGS OF PERCEIVED EXERTION: PREDICTING MOBILITY DISABILITY AND RESPONSE TO PHYSICAL ACTIVITY IN OLDER ADULTS Innovation In Aging 2019, 3: s969-s969. PMCID: PMC6845125, DOI: 10.1093/geroni/igz038.3512.
  • Predictors of Functional Decline Among Older Intensive Care Unit (ICU) SurvivorsFerrante L, Murphy T, Vander Wyk B, Leo-Summers L, Pisani M, Gill T. Predictors of Functional Decline Among Older Intensive Care Unit (ICU) Survivors 2019, a5674-a5674. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5674.
  • MORTALITY PREDICTION FOR OLDER ADULTS WITH AMI: THE SILVER-AMI STUDYDodson J, Hajduk A, Geda M, Krumholz H, Murphy T, Tsang S, Tinetti M, Nanna M, McNamara R, Gill T, Chaudhry S. MORTALITY PREDICTION FOR OLDER ADULTS WITH AMI: THE SILVER-AMI STUDY Journal Of The American College Of Cardiology 2019, 73: 102. DOI: 10.1016/s0735-1097(19)30710-7.
  • JOINT TRAJECTORIES OF COGNITION AND FRAILTY, AND ASSOCIATED BURDEN OF PATIENT-REPORTED OUTCOMESLiu Z, Han L, Gahbauer E, Allore H, Gill T. JOINT TRAJECTORIES OF COGNITION AND FRAILTY, AND ASSOCIATED BURDEN OF PATIENT-REPORTED OUTCOMES Innovation In Aging 2018, 2: 23-24. PMCID: PMC6226846, DOI: 10.1093/geroni/igy023.085.
  • Predictors of Discharge Home Among MICU Patients Receiving Early MobilizationKim R, Pisani M, Connors G, Murphy T, Tsang S, Wicker D, Gill T, Ferrante L. Predictors of Discharge Home Among MICU Patients Receiving Early Mobilization CHEST Journal 2017, 152: a337. DOI: 10.1016/j.chest.2017.08.363.
  • ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATHMurphy T, Pisani M, Ferrante L, Gill T. ASSOCIATIONS WITH POST-DISCHARGE FUNCTION OF OLDER ICU SURVIVORS: SENSITIVITY TO DEATH Innovation In Aging 2017, 1: 19-19. PMCID: PMC6241429, DOI: 10.1093/geroni/igx004.070.
  • SELF-REPORTED PHYSICAL FUNCTION AS A PREDICTOR OF HOSPITALIZATION IN THE LIFE STUDYCallahan K, Lovato L, Miller M, Marsh A, Gill T, Guralnik J, Kritchevsky S, Rejeski W. SELF-REPORTED PHYSICAL FUNCTION AS A PREDICTOR OF HOSPITALIZATION IN THE LIFE STUDY Innovation In Aging 2017, 1: 249-250. PMCID: PMC6243682, DOI: 10.1093/geroni/igx004.919.
  • STRIDE: A PRAGMATIC TRIAL OF A MULTIFACTORIAL APPROACH TO REDUCE SERIOUS FALLS INJURIESReuben D, Gill T, Lamb S. STRIDE: A PRAGMATIC TRIAL OF A MULTIFACTORIAL APPROACH TO REDUCE SERIOUS FALLS INJURIES Innovation In Aging 2017, 1: 1007-1007. PMCID: PMC6185039, DOI: 10.1093/geroni/igx004.3655.
  • STRIDE: ASCERTAINING SERIOUS FALL-RELATED INJURIES IN A PRAGMATIC TRIAL OF FALL PREVENTIONGanz D, Siu A, Magaziner J, Travison T, Gill T, Latham N. STRIDE: ASCERTAINING SERIOUS FALL-RELATED INJURIES IN A PRAGMATIC TRIAL OF FALL PREVENTION Innovation In Aging 2017, 1: 1008-1008. PMCID: PMC6184873, DOI: 10.1093/geroni/igx004.3659.
  • STRIDE: SCREENING AND RECRUITING OLDER PATIENTS AT RISK FOR SERIOUS FALL INJURIESGill T, McGloin J, Charpentier P, Araujo K, Skokos E, Latham N, Shelton A, Lu C. STRIDE: SCREENING AND RECRUITING OLDER PATIENTS AT RISK FOR SERIOUS FALL INJURIES Innovation In Aging 2017, 1: 1007-1007. PMCID: PMC6185546, DOI: 10.1093/geroni/igx004.3657.
  • Functional trajectories before and after a new cancer diagnosis among community-living older adults.Presley C, Hurria A, Han L, Leo-Summers L, Gross C, Allore H, Davidoff A, Gill T. Functional trajectories before and after a new cancer diagnosis among community-living older adults. Journal Of Clinical Oncology 2017, 35: e21547-e21547. DOI: 10.1200/jco.2017.35.15_suppl.e21547.
  • 0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONSMiner B, Redeker N, Yaggi H, Van Ness P, Han L, Gill T, Fragoso C. 0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONS Sleep 2017, 40: a280-a280. DOI: 10.1093/sleepj/zsx050.754.
  • 44Ferrante L, Pisani M, Murphy T, Gahbauer E, Leo-Summers L, Gill T. 44 Critical Care Medicine 2016, 44: 97. DOI: 10.1097/01.ccm.0000508762.61546.56.
  • O.122 Effet de l’exercice physique sur la fragilité et ses conséquences chez le sujet âgé : résultats de l’essai randomisé contrôlé LIFETrombetti A, Hars M, Hsu F, Reid K, Church T, Gill T, King A, Liu C, Manini T, Mcdermott M, Newman A, Rejeski J, Guralnik J, Pahor M, Fielding R. O.122 Effet de l’exercice physique sur la fragilité et ses conséquences chez le sujet âgé : résultats de l’essai randomisé contrôlé LIFE Revue Du Rhumatisme 2016, 83: a151-a152. DOI: 10.1016/s1169-8330(16)30315-5.
  • Patient-Reported Outcomes Collected as Part of the Medicare Annual Wellness Visit in the Health Care Systems Research NetworkTabano H, Gill T, Anzuoni K, Allore H, Gruber-Baldini A, Dublin S, Elliott T, Ganz D, Tai-Seale M, Gurwitz J, Bayliss E. Patient-Reported Outcomes Collected as Part of the Medicare Annual Wellness Visit in the Health Care Systems Research Network Journal Of Patient-Centered Research And Reviews 2016, 3: 168. DOI: 10.17294/2330-0698.1276.
  • PRESENTATION AND TREATMENT OF THE “OLDEST-OLD” HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION: THE SILVER AMI STUDYGupta A, Geda M, Murphy T, Tsang S, Gill T, McNamara R, Dodson J, Chaudhry S. PRESENTATION AND TREATMENT OF THE “OLDEST-OLD” HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION: THE SILVER AMI STUDY Journal Of The American College Of Cardiology 2016, 67: 557. DOI: 10.1016/s0735-1097(16)30558-7.
  • Physiology of the Aging LungMiner B, Gill T, Vaz Fragoso C. Physiology of the Aging Lung 2015, 39-70. DOI: 10.1142/9789814635011_0002.
  • Effects Of A Long-term Physical Activity Program On Accelerometry-based Sedentary Time In Older AdultsWanigatunga A, Ambrosius W, McDermott M, King A, Fielding R, Glynn N, Guralnik J, Tudor-Locke C, Gill T, Hire D, Pahor M, Manini T. Effects Of A Long-term Physical Activity Program On Accelerometry-based Sedentary Time In Older Adults Medicine & Science In Sports & Exercise 2015, 47: 515-516. DOI: 10.1249/01.mss.0000477849.39535.d3.
  • Effect Of Physical Activity On Self-reported Disability In Older AdultsManini T, Gill T, Beavers D, Guralnik J, Spring B, Church T, King A, Folta S, Glynn N, Marsh A, Pahor M. Effect Of Physical Activity On Self-reported Disability In Older Adults Medicine & Science In Sports & Exercise 2015, 47: 333. DOI: 10.1249/01.mss.0000466052.19947.a2.
  • Abstract 233: Physicians’ Perceptions of the Thrombolysis in Myocardial Infarction (TIMI) Risk Score in Older Adults with Acute Myocardial InfarctionFeder S, Schulman-Green D, Geda M, Dodson J, Tinetti M, Gill T, Chaudhry S. Abstract 233: Physicians’ Perceptions of the Thrombolysis in Myocardial Infarction (TIMI) Risk Score in Older Adults with Acute Myocardial Infarction Circulation Cardiovascular Quality And Outcomes 2014, 7 DOI: 10.1161/circoutcomes.7.suppl_1.233.
  • Combined effect of adiposity measures on physical performance in older adultsde Rekeneire N, Botoseneanu A, Allore H, Gill T. Combined effect of adiposity measures on physical performance in older adults European Geriatric Medicine 2013, 4: s90. DOI: 10.1016/j.eurger.2013.07.294.
  • SLOW GAIT AMONG OLDER ADULTS POST-AMI AND RISK FOR HOSPITAL READMISSIONDodson J, Reid K, Gill T, Krumholz H, Forman D, Spertus J, Rich M, Arnold S, Alexander K. SLOW GAIT AMONG OLDER ADULTS POST-AMI AND RISK FOR HOSPITAL READMISSION Journal Of The American College Of Cardiology 2012, 59: e1914. DOI: 10.1016/s0735-1097(12)61915-9.
  • Respiratory Impairment and Mortality in Older PersonsFragoso C, Gill T, McAvay G, Yaggi H, Van Ness P, Concato J. Respiratory Impairment and Mortality in Older Persons Journal Of Investigative Medicine 2011, 59: 1089. DOI: 10.2310/jim.0b013e31822bb213.
  • DEFINING CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OLDER PERSONSFragoso C, McAvay G, Van Ness P, Yaggi H, Rochester C, Concato J, Gill T. DEFINING CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OLDER PERSONS CHEST Journal 2008, 134: s27003-a-s27003-b. DOI: 10.1378/chest.134.4_meetingabstracts.s27003.
  • Vitamin E Concentration and Physical Decline in Older Persons—ReplyBartali B, Ferrucci L, Gill T. Vitamin E Concentration and Physical Decline in Older Persons—Reply JAMA 2008, 299: 2021-2021. DOI: 10.1001/jama.299.17.2021-b.
  • O001 THE EFFECT OF LEPTIN ON CHANGES IN ENERGY INTAKE IN COMMUNITY-LIVING OLDER PERSONSBartali B, Frongillo E, Laviano A, Ferrucci L, Guralnik J, Bandinelli S, Gill T. O001 THE EFFECT OF LEPTIN ON CHANGES IN ENERGY INTAKE IN COMMUNITY-LIVING OLDER PERSONS Clinical Nutrition 2008, 3: 1. DOI: 10.1016/s1744-1161(08)70003-6.
  • Shared Risk Factors for Falls, Incontinence, and Functional Dependence: Unifying the Approach to Geriatric SyndromesTinetti M, Inouye S, Gill T, Doucette J. Shared Risk Factors for Falls, Incontinence, and Functional Dependence: Unifying the Approach to Geriatric Syndromes JAMA 1995, 273: 1348-1353. DOI: 10.1001/jama.1995.03520410042024.
  • The Quality of Quality-of-Life Measurements-ReplyGill T, Feinstein A. The Quality of Quality-of-Life Measurements-Reply JAMA 1995, 273: 845-845. DOI: 10.1001/jama.1995.03520350025018.

Clinical Trials