Buqu Hu
Programmer Analyst Internal Medicine Pulmonary
Research & Publications
Biography
News
Coauthors
Selected Publications
- Circulating Mitochondrial DNA is associated with High Levels of Fatigue in Two Independent Sarcoidosis CohortsFiorini V, Hu B, Sun Y, Yu S, McGovern J, Gandhi S, Woo S, Turcotte-Foster S, Pivarnik T, Khan Z, Adams T, Herzog E, Kaminski N, Gulati M, Ryu C. Circulating Mitochondrial DNA is associated with High Levels of Fatigue in Two Independent Sarcoidosis Cohorts. CHEST Journal 2023 PMID: 37977267, DOI: 10.1016/j.chest.2023.11.020.
- Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung InjuryHarris Z, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin H, Manning E, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury. 2023, a1256-a1256. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1256.
- Mitochondrial DNA-toll-like Receptor 9 Interactions Drives Fibrosis in the Adult LungRyu C, Hu B, Sun Y, Yu S, Woo S, Fiorini V, Pivarnik T, Mcgovern J, Peng X, Herzog E, Trujillo G. Mitochondrial DNA-toll-like Receptor 9 Interactions Drives Fibrosis in the Adult Lung. 2023, a1376-a1376. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1376.
- Protracted Pulmonary Inflammation in IFN-gamma Deficient Mice Recovering From Cytokine Release SyndromeRajagopalan G, Sun Y, Hu B, Harris Z, Stanely G, Koff J. Protracted Pulmonary Inflammation in IFN-gamma Deficient Mice Recovering From Cytokine Release Syndrome. 2023, a1386-a1386. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1386.
- Serum Collagen Neoepitopes Are Associated With Multi-organ Disease in the Access and GRADS Sarcoidosis CohortsRyu C, Sand J, Juhl P, Jessen H, Leeming D, Hu B, Sun Y, Adams T, Pivarnik T, Yu S, Woo S, McGovern J, Fiorini V, Goobie G, Zhang Y, Herzog E. Serum Collagen Neoepitopes Are Associated With Multi-organ Disease in the Access and GRADS Sarcoidosis Cohorts. 2023, a2242-a2242. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2242.
- Plasma Mitochondrial DNA Is Associated With Patient-related Outcome Measures in SarcoidosisFiorini V, Hu B, Sun Y, Yu S, McGovern J, Woo S, Khan Z, Adams T, Pivarnik T, Herzog E, Ryu C. Plasma Mitochondrial DNA Is Associated With Patient-related Outcome Measures in Sarcoidosis. 2023, a2275-a2275. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2275.
- Elevated Levels of Mitochondrial DNA and CGAS Ligands Are Found in Scleroderma Associated Interstitial Lung Disease and Mediate Fibroblast ActivationYu S, Woo S, Hu B, Sun Y, Fiorini V, Van Horn C, Gunes B, Hinchcliff M, Varga J, Herzog E, Ryu C. Elevated Levels of Mitochondrial DNA and CGAS Ligands Are Found in Scleroderma Associated Interstitial Lung Disease and Mediate Fibroblast Activation. 2023, a2279-a2279. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2279.
- A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa InfectionsGeyer J, Krupa K, Harris Z, Sun Y, Sharma L, Würstle S, Hu B, Stanley G, Rajagopalan G, Pellot E, Koff J, Robinson J. A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa Infections. Antibiotics 2023, 12: 735. PMID: 37107097, PMCID: PMC10135120, DOI: 10.3390/antibiotics12040735.
- α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosisIshikawa G, Peng X, McGovern J, Woo S, Perry C, Liu A, Yu S, Ghincea A, Kishchanka A, Fiorini V, Hu B, Sun Y, Sun H, Ryu C, Herzog E. α1 Adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with idiopathic pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2023, 324: l639-l651. PMID: 36648147, PMCID: PMC10110730, DOI: 10.1152/ajplung.00119.2022.
- IFN-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury.Sun Y, Hu B, Stanley G, Harris ZM, Gautam S, Homer R, Koff JL, Rajagopalan G. IFN-γ Is Protective in Cytokine Release Syndrome-associated Extrapulmonary Acute Lung Injury. American Journal Of Respiratory Cell And Molecular Biology 2023, 68: 75-89. PMID: 36125351, PMCID: PMC9817908, DOI: 10.1165/rcmb.2022-0117oc.
- PATIENT-RELATED OUTCOMES AND BIOLOGIC MEDIATORS OF SARCOIDOSISFIORINI V, MCGOVERN J, HU B, SUN Y, KHAN Z, HERZOG E, RYU C. PATIENT-RELATED OUTCOMES AND BIOLOGIC MEDIATORS OF SARCOIDOSIS. CHEST Journal 2022, 162: a2692. DOI: 10.1016/j.chest.2022.08.2191.
- 563 Novel porphyrin targets biofilm, Pseudomonas aeruginosa, and Staphylococcus aureusHarris Z, Geyer J, Sun Y, Hu B, Wuerstle S, Stanley G, Rajagopalan G, Robinson J, Koff J. 563 Novel porphyrin targets biofilm, Pseudomonas aeruginosa, and Staphylococcus aureus. Journal Of Cystic Fibrosis 2022, 21: s313-s314. DOI: 10.1016/s1569-1993(22)01253-x.
- Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung InjuryHarris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury. Oxidative Medicine And Cellular Longevity 2022, 2022: 9518592. PMID: 36193076, PMCID: PMC9526641, DOI: 10.1155/2022/9518592.
- Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis in Hyperoxia-Induced Lung InjuryHarris Z, Sun Y, Joerns J, Clark B, Hu B, Korde A, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang M, Koff J. Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis in Hyperoxia-Induced Lung Injury. 2022, a2517-a2517. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2517.
- Reducing asthma exacerbations in vulnerable children through a medical–legal partnershipMainardi AS, Harris D, Rosenthal A, Redlich CA, Hu B, Fenick AM. Reducing asthma exacerbations in vulnerable children through a medical–legal partnership. Journal Of Asthma 2022, 60: 262-269. PMID: 35188437, DOI: 10.1080/02770903.2022.2045307.
- 514: Novel zinc porphyrin antibiotic shows activity against Pseudomonas in vivoHarris Z, Geyer J, Sun Y, Hu B, Stanley G, Rajagopalan G, Robinson J, Koff J. 514: Novel zinc porphyrin antibiotic shows activity against Pseudomonas in vivo. Journal Of Cystic Fibrosis 2021, 20: s243-s244. DOI: 10.1016/s1569-1993(21)01938-x.
- Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosisVukmirovic M, Yan X, Gibson KF, Gulati M, Schupp JC, DeIuliis G, Adams TS, Hu B, Mihaljinec A, Woolard TN, Lynn H, Emeagwali N, Herzog EL, Chen ES, Morris A, Leader JK, Zhang Y, Garcia JGN, Maier LA, Collman RG, Drake WP, Becich MJ, Hochheiser H, Wisniewski SR, Benos PV, Moller DR, Prasse A, Koth LL, Kaminski N. Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis. European Respiratory Journal 2021, 58: 2002950. PMID: 34083402, PMCID: PMC9759791, DOI: 10.1183/13993003.02950-2020.
- Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis via ERK1/2 in Hyperoxia-Induced Lung InjuryHarris Z, Korde A, Sun Y, Hu B, Rajagopalan G, Stanley G, Joerns J, Clark B, Koff J. Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis via ERK1/2 in Hyperoxia-Induced Lung Injury. 2021, a4367-a4367. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4367.
- Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiencyChu JH, Zang W, Vukmirovic M, Yan X, Adams T, DeIuliis G, Hu B, Mihaljinec A, Schupp JC, Becich MJ, Hochheiser H, Gibson KF, Chen ES, Morris A, Leader JK, Wisniewski SR, Zhang Y, Sciurba FC, Collman RG, Sandhaus R, Herzog EL, Patterson KC, Sauler M, Strange C, Kaminski N. Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency. Thorax 2020, 76: 134-143. PMID: 33303696, PMCID: PMC10794043, DOI: 10.1136/thoraxjnl-2019-214301.
- Bacteriophage Therapy Decreases Pseudomonas Aeruginosa Lung InflammationStanley G, Chan B, Ott I, Mayo E, Harris Z, Sun Y, Hu B, Rajagopalan G, Turner P, Koff J. Bacteriophage Therapy Decreases Pseudomonas Aeruginosa Lung Inflammation. 2020, a2977-a2977. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2977.
- Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor ReceptorHarris Z, Chioccioli M, Joerns J, Clark B, Sun Y, Hu B, Stanley G, Rajagopalan G, Koff J. Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor Receptor. 2020, a5551-a5551. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5551.
- IL-17A and IFN-gamma Play Distinct Roles in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome Induced by a Staphylococcal SuperantigenRajagopalan G, Coutermarsh-Ott S, Sun Y, Hu B, Harris Z, Stanley G, Koff J. IL-17A and IFN-gamma Play Distinct Roles in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome Induced by a Staphylococcal Superantigen. 2020, a7708-a7708. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7708.
- Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosisRyu C, Brandsdorfer C, Adams T, Hu B, Kelleher DW, Yaggi M, Manning EP, Walia A, Reeves B, Pan H, Winkler J, Minasyan M, Dela Cruz CS, Kaminski N, Gulati M, Herzog EL. Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis. European Respiratory Journal 2019, 54: 1801762. PMID: 31273041, PMCID: PMC8088542, DOI: 10.1183/13993003.01762-2018.
- Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPFVukmirovic M, Brereton C, Yan X, Xylourgidis N, Deluliis G, Woolard T, Hu B, Mihaljinec A, Homer R, Maya J, Ahangari F, Fabre A, Smart D, Conforti F, Marshall B, Alzetani A, Davies D, Richeldi L, Kaminski N, Jones M. Alveolar and Fibroblast Foci Specific Genome-Wide Gene Expression Profiling Identifies Common Dysregulated Expression of CREB1, a Regulator Across Cell Types, in IPF. 2019, a5262-a5262. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5262.
- Human Lung MicroRNA-1 Is Regulated by IL-13 and Correlates with Tissue Eosinophilia in Airway InflammationHu B, Korde A, Cohn L, Chu J, Takyar S. Human Lung MicroRNA-1 Is Regulated by IL-13 and Correlates with Tissue Eosinophilia in Airway Inflammation. 2019, a2931-a2931. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2931.
- Lung Endothelial MicroRNA-1 Regulates Tumor Growth and AngiogenesisKorde A, Jin L, Zhang JG, Ramaswamy A, Hu B, Kolahian S, Guardela BJ, Herazo-Maya J, Siegfried JM, Stabile L, Pisani MA, Herbst RS, Kaminski N, Elias JA, Puchalski JT, Takyar SS. Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis. American Journal Of Respiratory And Critical Care Medicine 2017, 196: 1443-1455. PMID: 28853613, PMCID: PMC5736970, DOI: 10.1164/rccm.201610-2157oc.
- Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosisMurray LA, Habiel DM, Hohmann M, Camelo A, Shang H, Zhou Y, Coelho AL, Peng X, Gulati M, Crestani B, Sleeman MA, Mustelin T, Moore MW, Ryu C, Osafo-Addo AD, Elias JA, Lee CG, Hu B, Herazo-Maya JD, Knight DA, Hogaboam CM, Herzog EL. Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis. JCI Insight 2017, 2: e92192. PMID: 28814671, PMCID: PMC5621899, DOI: 10.1172/jci.insight.92192.
- Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosisPeng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, Herazo‐Maya J, Kaminski N, Hu X, Pan H, Ryu C, Osafo‐Addo A, Homer RJ, Feghali‐Bostwick C, Fares W, Gulati M, Hu B, Lee C, Elias JA, Herzog EL. Plexin C1 deficiency permits synaptotagmin 7–mediated macrophage migration and enhances mammalian lung fibrosis. The FASEB Journal 2016, 30: 4056-4070. PMID: 27609773, PMCID: PMC5102121, DOI: 10.1096/fj.201600373r.
- The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational studyHoang QN, Pisani MA, Inzucchi S, Hu B, Honiden S. The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: A prospective observational study. Journal Of Critical Care 2014, 29: 1052-1056. PMID: 25092614, DOI: 10.1016/j.jcrc.2014.06.007.
- Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung FibrosisZhou Y, Peng H, Sun H, Peng X, Tang C, Gan Y, Chen X, Mathur A, Hu B, Slade MD, Montgomery RR, Shaw AC, Homer RJ, White ES, Lee CM, Moore MW, Gulati M, Lee CG, Elias JA, Herzog EL. Chitinase 3–Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis. Science Translational Medicine 2014, 6: 240ra76. PMID: 24920662, PMCID: PMC4340473, DOI: 10.1126/scitranslmed.3007096.
- LOT: a tool for linkage analysis of ordinal traits for pedigree dataZhang M, Feng R, Chen X, Hu B, Zhang H. LOT: a tool for linkage analysis of ordinal traits for pedigree data. Bioinformatics 2008, 24: 1737-1739. PMID: 18535081, PMCID: PMC2566542, DOI: 10.1093/bioinformatics/btn258.
- IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine LungZheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA. IL-13 Receptor α2 Selectively Inhibits IL-13-Induced Responses in the Murine Lung. The Journal Of Immunology 2008, 180: 522-529. PMID: 18097054, DOI: 10.4049/jimmunol.180.1.522.
- Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammationHerzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, Krause DS. Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. The FASEB Journal 2007, 21: 2592-2601. PMID: 17449722, DOI: 10.1096/fj.06-7861com.
- Threshold of Lung Injury Required for the Appearance of Marrow‐Derived Lung EpitheliaHerzog EL, Van Arnam J, Hu B, Krause DS. Threshold of Lung Injury Required for the Appearance of Marrow‐Derived Lung Epithelia. Stem Cells 2006, 24: 1986-1992. PMID: 16868209, DOI: 10.1634/stemcells.2005-0579.