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George Tellides, MD, PhD

Professor of Surgery (Cardiac); Chief of Cardiothoracic Surgery, Veterans Affairs Medical Center

Research & Publications
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Selected Publications

Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cellsWang S, Song G, Barkestani M, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober J, Tellides G, Jane-wit D. Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells. Frontiers In Immunology 2023, 14: 1248027. PMID: 37915586, PMCID: PMC10616247, DOI: 10.3389/fimmu.2023.1248027.
Recruited macrophages elicit atrial fibrillationHulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.
Acetate controls endothelial-to-mesenchymal transitionZhu X, Wang Y, Soaita I, Lee H, Bae H, Boutagy N, Bostwick A, Zhang R, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder N, Yu L, Arany Z, Simons M. Acetate controls endothelial-to-mesenchymal transition. Cell Metabolism 2023, 35: 1163-1178.e10. PMID: 37327791, PMCID: PMC10529701, DOI: 10.1016/j.cmet.2023.05.010.
Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cellsLi X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober J, Jane-wit D. Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nature Communications 2023, 14: 3336. PMID: 37286577, PMCID: PMC10247709, DOI: 10.1038/s41467-023-39154-5.
A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cellsLi X, Jiang Q, Song G, Barkestani M, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober J, Jane-wit D. A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells. Nature Communications 2023, 14: 3002. PMID: 37225719, PMCID: PMC10209169, DOI: 10.1038/s41467-023-38684-2.
Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeriaMurtada S, Kawamura Y, Cavinato C, Wang M, Ramachandra A, Spronck B, Li D, Tellides G, Humphrey J. Biomechanical and transcriptional evidence that smooth muscle cell death drives an osteochondrogenic phenotype and severe proximal vascular disease in progeria. Biomechanics And Modeling In Mechanobiology 2023, 22: 1333-1347. PMID: 37149823, PMCID: PMC10544720, DOI: 10.1007/s10237-023-01722-5.
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in miceLee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. DOI: 10.1038/s44161-023-00266-2.
Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Lee P, Heerdt P, Singh I, Tellides G, Kaminski N, Humphrey J. Pulmonary Hypertension-related Changes in Structure and Function of the Human Proximal Pulmonary Artery. 2023, a6133-a6133. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6133.
Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.
The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During AgingYuan Y, Khoury J, Ramachandra A, Singh I, Tellides G, Humphrey J, Kaminski N, Manning E. The Extracellular Matrix of the Human Proximal Pulmonary Artery Regulates Gene Expression of Resident Cells Responsible for Remodeling During Aging. 2023, a2680-a2680. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2680.
FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan SyndromeChen M, Cavinato C, Hansen J, Tanaka K, Ren P, Hassab A, Li D, Youshao E, Tellides G, Iyengar R, Humphrey J, Schwartz M. FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: e132-e150. PMID: 36994727, PMCID: PMC10133209, DOI: 10.1161/atvbaha.123.319120.
Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cellsJiang B, Wang S, Song G, Jiang Q, Fan M, Fang C, Li X, Soh C, Manes T, Cheru N, Qin L, Ren P, Jortner B, Wang Q, Quaranta E, Yoo P, Geirsson A, Davis R, Tellides G, Pober J, Jane-Wit D. Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells. Science Signaling 2023, 16: eabo3406. PMID: 36943921, PMCID: PMC10061549, DOI: 10.1126/scisignal.abo3406.
Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndromeMurtada S, Mikush N, Wang M, Ren P, Kawamura Y, Ramachandra A, Li D, Braddock D, Tellides G, Gordon L, Humphrey J. Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford progeria syndrome. ELife 2023, 12: e82728. PMID: 36930696, PMCID: PMC10023154, DOI: 10.7554/elife.82728.
Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic AneurysmToczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.
Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion RemodelingCanfrán-Duque A, Rotllan N, Zhang X, Andrés-Blasco I, Thompson B, Sun J, Price N, Fernández-Fuertes M, Fowler J, Gómez-Coronado D, Sessa W, Giannarelli C, Schneider R, Tellides G, McDonald J, Fernández-Hernando C, Suárez Y. Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling. Circulation 2022, 147: 388-408. PMID: 36416142, PMCID: PMC9892282, DOI: 10.1161/circulationaha.122.059062.
Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary ArteryManning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Singh I, Tellides G, Gill T, Kaminski N, Humphrey J. Structural, Functional, and Single Cell Transcriptomic Age-Related Remodeling of Mouse Proximal Pulmonary Artery. 2022, a5205-a5205. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5205.
307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular VesselLawson J, Wang J, Han E, Kural M, Jiang B, Leiby K, Chowdhury N, Tellides G, Niklason L. 307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel. Transplantation 2021, 105: s26-s26. DOI: 10.1097/01.tp.0000804428.49042.2a.
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosisZhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2107682118. PMID: 34782454, PMCID: PMC8617522, DOI: 10.1073/pnas.2107682118.
PERCUTANEOUS COIL EMBOLIZATION OF A GIANT SAPHENOUS VEIN GRAFT PSEUDOANEURYSMCleman J, Hur D, Mullan C, Varma P, Tellides G, Shah S. PERCUTANEOUS COIL EMBOLIZATION OF A GIANT SAPHENOUS VEIN GRAFT PSEUDOANEURYSM. Journal Of The American College Of Cardiology 2021, 77: 1908. DOI: 10.1016/s0735-1097(21)03264-2.
GENETIC BACKGROUND DOMINATES FIBROTIC AORTIC REMODELING DURING ANGIOTENSIN-INDUCED HYPERTENSION IN MICESpronck B, Caulk A, Ramachandra A, Murtada S, Rojas A, He C, Bersi M, Tellides G, Humphrey J. GENETIC BACKGROUND DOMINATES FIBROTIC AORTIC REMODELING DURING ANGIOTENSIN-INDUCED HYPERTENSION IN MICE. Journal Of Hypertension 2021, 39: e54. DOI: 10.1097/01.hjh.0000744928.37440.18.
ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T CellsJiang B, Fang C, Soh C, Li X, Geirsson A, Tellides G, Pober J, Jane-Wit D. ZFYVE21 is a Mediator of Non-Canonical Hedgehog Signaling Activating NLRP3 Inflammasomes in a Pathologic Subset of CD4+PD-1hi T Cells. The Journal Of Heart And Lung Transplantation 2021, 40: s136. DOI: 10.1016/j.healun.2021.01.422.
Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signalingKawamura Y, Murtada S, Gao F, Liu X, Tellides G, Humphrey J. Adventitial remodeling protects against aortic rupture following late smooth muscle-specific disruption of TGFβ signaling. Journal Of The Mechanical Behavior Of Biomedical Materials 2021, 116: 104264. PMID: 33508556, PMCID: PMC7959590, DOI: 10.1016/j.jmbbm.2020.104264.
P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive MiceSpronck B, Latorre M, Mehta S, Caulk A, Ramachandra A, Murtada S, Rojas A, He C, Jiang B, Wang M, Bersi M, Tellides G, Humphrey J. P.58 Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice. Artery Research 2020, 26: s81-s82. DOI: 10.2991/artres.k.201209.068.
Abstract 14296: Differential Left and Right Ventricle Response to Cold Storage Followed by Reperfusion in Heart TransplantationLei I, Huang W, Pagani F, Chen E, Wang Z, Pober J, Tellides G, Perelli R, Shashi V, Landstrom A, TANG P. Abstract 14296: Differential Left and Right Ventricle Response to Cold Storage Followed by Reperfusion in Heart Transplantation. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.14296.
Abstract 215: Cardiac Surgeons' Treatment Preferences for Infective Endocarditis Based on Patients' Drug Use StatusNguemeni Tiako M, Mori M, Bin Mahmood S, Mszar R, Brooks C, Bonde P, Tellides G, Weimer M, Geirsson A. Abstract 215: Cardiac Surgeons' Treatment Preferences for Infective Endocarditis Based on Patients' Drug Use Status. Circulation Cardiovascular Quality And Outcomes 2020, 13 DOI: 10.1161/hcq.13.suppl_1.215.
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosisChen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.
ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft VasculopathyJane-Wit D, Fang C, Liu L, Qin L, Li G, Tellides G, Pober J. ZFYVE21 is a Novel Complement-Induced Rab5 Effector Protein Mediating Cardiac Allograft Vasculopathy. The Journal Of Heart And Lung Transplantation 2019, 38: s249. DOI: 10.1016/j.healun.2019.01.618.
Central artery stiffness and thoracic aortopathyHumphrey J, Tellides G. Central artery stiffness and thoracic aortopathy. AJP Heart And Circulatory Physiology 2018, 316: h169-h182. PMID: 30412443, PMCID: PMC6880196, DOI: 10.1152/ajpheart.00205.2018.
Chapter 7 Vascular mechanobiology, immunobiology, and arterial growth and remodelingCaulk A, Tellides G, Humphrey J. Chapter 7 Vascular mechanobiology, immunobiology, and arterial growth and remodeling. 2018, 215-248. DOI: 10.1016/b978-0-12-812952-4.00007-6.
(1365) In Vivo Anti-MicroRNA Treatment in a Humanized Mouse Model for Allograft VasculopathyHuibers M, Qin L, Li G, Renes J, Venema C, Koning E, van Kuik J, Peeters T, Tellides G, de Weger R. (1365) In Vivo Anti-MicroRNA Treatment in a Humanized Mouse Model for Allograft Vasculopathy. The Journal Of Heart And Lung Transplantation 2017, 36: s446. DOI: 10.1016/j.healun.2017.01.1277.
Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized MiceQin L, Li G, Kirkiles‐Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane‐Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.
Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque CalcificationCeneri N, Zhao L, Young B, Healy A, Coskun S, Vasavada H, Yarovinsky T, Ike K, Qin L, Pardi R, Meadows J, Tellides G, Hirschi K, Soufer R, Sadeghi M, Bender J, Morrison A. Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque Calcification. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.655.
Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosisMisra A, Sheikh A, Kumar A, Luo J, Zhang J, Hinton R, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif D. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. The Journal Of General Physiology 2016, 147: 1473oia18. DOI: 10.1085/jgp.1473oia18.
MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934)Zhou J, yi T, Qin L, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. MHC class II-disparate heart but not skin allografts accelerate recipient cardiovascular disease (TRAN1P.934). The Journal Of Immunology 2015, 194: 140.16-140.16. DOI: 10.4049/jimmunol.194.supp.140.16.
Corrigendum to “Disruption of TGF- signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm” [Biochem. Biophys. Res. Commun. 454 (1) (7 November 2014) 137–143]Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W. Corrigendum to “Disruption of TGF- signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm” [Biochem. Biophys. Res. Commun. 454 (1) (7 November 2014) 137–143]. Biochemical And Biophysical Research Communications 2015, 460: 887. DOI: 10.1016/j.bbrc.2015.04.001.
Abstract 219: IFN-γ Plays an Essential Role in Accelerating Cardiovascular Disease of Recipients With MHC Class II-mismatched Allografts.Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Zhang J, Sadeghi M, Pober J, Tellides G. Abstract 219: IFN-γ Plays an Essential Role in Accelerating Cardiovascular Disease of Recipients With MHC Class II-mismatched Allografts. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.219.
Abstract 417: Endosome-Based Activation of Non-Canonical NF-kB Signaling by Complement Membrane Attack ComplexesJane-wit D, Surovtseva Y, Qin L, Liu R, Clark P, Manes T, Wang C, Kashgarian M, Kirkiles-Smith N, Tellides G, Pober J. Abstract 417: Endosome-Based Activation of Non-Canonical NF-kB Signaling by Complement Membrane Attack Complexes. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.417.
A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysmsDi Achille P, Tellides G, Figueroa C, Humphrey J. A haemodynamic predictor of intraluminal thrombus formation in abdominal aortic aneurysms. Proceedings Of The Royal Society A 2014, 470: 20140163. DOI: 10.1098/rspa.2014.0163.
Abstract 155: Sustained CD4+ T-Cell Activation Promotes Transplant-Associated Recipient Cardiovascular DiseaseZhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Sadeghi M, Giordano F, Pober J, Tellides G. Abstract 155: Sustained CD4+ T-Cell Activation Promotes Transplant-Associated Recipient Cardiovascular Disease. Arteriosclerosis Thrombosis And Vascular Biology 2014, 34 DOI: 10.1161/atvb.34.suppl_1.155.
(875) Localization of microRNAs in Cardiac Allograft Vasculopathy With In Situ Hybridization; a Role in Immune Regulation and/or Fibrosis?Huibers M, van Holthe tot Echten B, Peeters T, de Jonge N, Tellides G, de Weger R. (875) Localization of microRNAs in Cardiac Allograft Vasculopathy With In Situ Hybridization; a Role in Immune Regulation and/or Fibrosis? The Journal Of Heart And Lung Transplantation 2014, 33: s315. DOI: 10.1016/j.healun.2014.01.852.
Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2Wang C, Qin L, Manes T, Kirkiles-Smith N, Tellides G, Pober J. Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2. Journal Of Cell Biology 2014, 204: 2044oia30. DOI: 10.1083/jcb.2044oia30.
IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHYJane–Wit D, Pober J, Tellides G. IDENTIFICATION OF A NOVEL COMPLEMENT–INDUCED SIGNALING PATHWAY IN ENDOTHELIAL CELLS THAT IS IMPLICATED IN THE DEVELOPMENT OF CORONARY GRAFT VASCULOPATHY. Journal Of The American College Of Cardiology 2013, 61: e2109. DOI: 10.1016/s0735-1097(13)62109-9.
CTLA4-IG MEDIATED TOLERANCE INDUCTION RELIES ON INTERRELATED MECHANISMS INVOLVING THE IMMUNOMODULATORY ENZYME IDO AND TREGSucher R, Oberhuber R, Fischler N, Kronberger I, Öllinger R, Schneeberger S, Fuchs D, Werner E, Zelger B, Tellides G, Pilat N, Wekerle T, Margreiter R, Pratschke J, Brandacher G. CTLA4-IG MEDIATED TOLERANCE INDUCTION RELIES ON INTERRELATED MECHANISMS INVOLVING THE IMMUNOMODULATORY ENZYME IDO AND TREG. Transplantation 2010, 90: 57. DOI: 10.1097/00007890-201007272-00109.
W15 THE ANTIPROLIFERATIVE EFFECT OF LRP6 AND ITS IMPAIRMENT BY R611C MUTATION ARE MEDIATED BY INDEPENDENT INTERMEDIATES OF THE PDGF PATHWAYKeramati A, Singh R, Liu W, Faramarzi S, Nottoli T, Tellides G, Mani A. W15 THE ANTIPROLIFERATIVE EFFECT OF LRP6 AND ITS IMPAIRMENT BY R611C MUTATION ARE MEDIATED BY INDEPENDENT INTERMEDIATES OF THE PDGF PATHWAY. Atherosclerosis Plus 2010, 11: 4. DOI: 10.1016/s1567-5688(10)70016-7.
Graft-derived IL-6 Promotes Allogeneic T Cell Intimal Infiltration and Intimal Expansion in a Chimeric Mouse Model of Human Artery RejectionFogal B, Rao D, Yi T, Tellides G, Kulkarni S, Pober J. Graft-derived IL-6 Promotes Allogeneic T Cell Intimal Infiltration and Intimal Expansion in a Chimeric Mouse Model of Human Artery Rejection. Clinical Immunology 2010, 135: s42. DOI: 10.1016/j.clim.2010.03.127.
Graft-derived IL-6 Promotes Allogeneic T Cell Intimal Infiltration and Intimal Expansion in a Chimeric Mouse Model of Human Artery RejectionFogal B, Rao D, Yi T, Tellides G, Kulkarni S, Pober J. Graft-derived IL-6 Promotes Allogeneic T Cell Intimal Infiltration and Intimal Expansion in a Chimeric Mouse Model of Human Artery Rejection. Clinical Immunology 2010, 135: s29. DOI: 10.1016/j.clim.2010.03.091.
Indoleamine 2,3-dioxygenase (IDO) and T-regulatory cells are key players in CTLA4-Ig-mediated tolerance inductionSucher R, Fischler N, Oberhuber R, Schneeberger S, Fuchs D, Margreiter R, Zelger B, Tellides G, Wekerle T, Brandacher G. Indoleamine 2,3-dioxygenase (IDO) and T-regulatory cells are key players in CTLA4-Ig-mediated tolerance induction. Journal Of The American College Of Surgeons 2009, 209: s56. DOI: 10.1016/j.jamcollsurg.2009.06.132.
446: Dynamic Regulation of Micro RNAs in Ischemic Cardiac Remodeling and Heart FailureAli R, Kim R, Tellides G, Geirsson A. 446: Dynamic Regulation of Micro RNAs in Ischemic Cardiac Remodeling and Heart Failure. The Journal Of Heart And Lung Transplantation 2009, 28: s220-s221. DOI: 10.1016/j.healun.2008.11.453.
Endothelial nitric oxide synthase (eNOS) mediates aneurysm formation in aged micePimiento J, Maloney S, Tang P, Muto A, Fitzgerald T, Fancher T, Dudrick S, Tellides G, Dardik A. Endothelial nitric oxide synthase (eNOS) mediates aneurysm formation in aged mice. Journal Of The American College Of Surgeons 2007, 205: s41. DOI: 10.1016/j.jamcollsurg.2007.06.095.
Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human ArteryKawikova I, Tai Y, Lorber M, Tellides G, Pober J, Bothwell A. Activation of Transcription Factor PPARgamma In Vivo Protects Against Alloreactive Vascular Remodeling of Human Artery. Clinical Immunology 2007, 123: s175-s176. DOI: 10.1016/j.clim.2007.03.141.
Murine carotid aneurysms develop without down regulation of Nogo-B expression: A novel model for human thoracic aneurysmsMaloney S, Yakimov A, Muto A, Tang P, Pimiento J, Kudo F, Westvik T, Dudrick S, Sessa W, Tellides G, Dardik A. Murine carotid aneurysms develop without down regulation of Nogo-B expression: A novel model for human thoracic aneurysms. Journal Of The American College Of Surgeons 2006, 203: s22. DOI: 10.1016/j.jamcollsurg.2006.05.053.
The role of the MyD88 pathway in arterial remodelingMcRae M, Gallo A, Saad A, Cuffy M, Tellides G. The role of the MyD88 pathway in arterial remodeling. Journal Of The American College Of Surgeons 2006, 203: s104. DOI: 10.1016/j.jamcollsurg.2006.05.273.
Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysmTang P, Yakimov A, Teesdale M, Coady M, Dardik A, Elefteriades J, Tellides G. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysm. Journal Of Surgical Research 2006, 130: 289. DOI: 10.1016/j.jss.2005.11.372.
ROLE OF INTERFERON- GAMMA IN REDUCING HUMAN ARTERIAL INJURY IN THE SCID- HUMAN TRANSPALNT MODEL; EFFECTS OF SIROLIMUS AND CYCLOSPORINELorber M, Yi T, Geiselhart L, Wang Y, Schechner J, Tellides G, Pober J. ROLE OF INTERFERON- GAMMA IN REDUCING HUMAN ARTERIAL INJURY IN THE SCID- HUMAN TRANSPALNT MODEL; EFFECTS OF SIROLIMUS AND CYCLOSPORINE. Transplantation 2004, 78: 607. DOI: 10.1097/00007890-200407271-01633.
HUMAN ALLOGENEIC T CELL-MEDIATED VASCULAR DYSFUNCTION DEPENDS ON INTERFERON-GAMMAKoh K, Wang Y, Yi T, Lorber M, Sessa W, Tellides G, Pober J. HUMAN ALLOGENEIC T CELL-MEDIATED VASCULAR DYSFUNCTION DEPENDS ON INTERFERON-GAMMA. Cardiovascular Pathology 2004, 13: 9. DOI: 10.1016/j.carpath.2004.03.021.
Gamma-interferon-dependent T cell-mediated injury and remodeling of human coronary arteriesWang Y, Burns W, Tang P, Bai Y, Yi T, Schechner J, Lorber M, Pober J, Tellides G. Gamma-interferon-dependent T cell-mediated injury and remodeling of human coronary arteries. The Journal Of Heart And Lung Transplantation 2003, 22: s154-s155. DOI: 10.1016/s1053-2498(02)00944-0.
Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass graftingKim R, Mariconda D, Tellides G, Kopf G, Dewar M, Lin Z, Elefteriades J. Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting. European Journal Of Cardio-Thoracic Surgery 2001, 20: 127-132. PMID: 11423285, DOI: 10.1016/s1010-7940(01)00765-5.
HUMAN T CELLS INFILTRATE AND INJURE PIG CORONARY ARTERY GRAFTS WITH ACTIVATED BUT NOT QUIESCENT ENDOTHELIUM IN IMMUNODEFICIENT MOUSE HOSTS1Tereb D, Kirkiles-Smith N, Kim R, Wang Y, Rudic R, Schechner J, Lorber M, Bothwell A, Pober J, Tellides G. HUMAN T CELLS INFILTRATE AND INJURE PIG CORONARY ARTERY GRAFTS WITH ACTIVATED BUT NOT QUIESCENT ENDOTHELIUM IN IMMUNODEFICIENT MOUSE HOSTS1. Transplantation 2001, 71: 1622-1630. PMID: 11435975, DOI: 10.1097/00007890-200106150-00023.
Endothelial expression of tissue factor on saphenous vein and internal mammary artery segmentsUgurlu B, Tellides G, Tereb D. Endothelial expression of tissue factor on saphenous vein and internal mammary artery segments. International Journal Of Angiology 2001, 10: 101-102. DOI: 10.1007/bf01616412.
Endothelial expression of tissue factor on saphenous vein and internal mammary artery segmentsUgurlu B, Tellides G, Tereb D. Endothelial expression of tissue factor on saphenous vein and internal mammary artery segments. International Journal Of Angiology 2001, 101-102. DOI: 10.1055/s-0031-1276291.
Effect of left ventricular volume on results of coronary artery bypass graftingKim R, Ugurlu B, Tereb D, Wackers F, Tellides G, Elefteriades J. Effect of left ventricular volume on results of coronary artery bypass grafting. The American Journal Of Cardiology 2000, 86: 1261-1264. PMID: 11090805, DOI: 10.1016/s0002-9149(00)01216-9.
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouseSchechner J, Nath A, Zheng L, Kluger M, Hughes C, Sierra-Honigmann M, Lorber M, Tellides G, Kashgarian M, Bothwell A, Pober J. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 9191-9196. PMID: 10890921, PMCID: PMC16844, DOI: 10.1073/pnas.150242297.
Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse HostsKirkiles-Smith N, Tereb D, Kim R, McNiff J, Schechner J, Lorber M, Pober J, Tellides G. Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts. The Journal Of Immunology 2000, 164: 6601-6609. PMID: 10843720, DOI: 10.4049/jimmunol.164.12.6601.
Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertensionElefteriades J, Lovoulos C, Tellides G, Goldstein L, Rocco E, Condos S, Kopf G. Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension. The Annals Of Thoracic Surgery 2000, 69: 1858-1863. PMID: 10892937, DOI: 10.1016/s0003-4975(00)01318-7.
Interferon-γ elicits arteriosclerosis in the absence of leukocytesTellides G. Interferon-γ elicits arteriosclerosis in the absence of leukocytes. Biomedicine & Pharmacotherapy 2000, 54: 221. DOI: 10.1016/s0753-3322(00)89034-4.
HUMAN T CELLS DO NOT INFILTRATE OR INJURE PIG CORONARY ARTERY GRAFTS IN IMMUNODEFICIENT MOUSE HOSTS.Tereb D, KirkilesSmith N, Kim R, Pober J, Lorber M, Tellides G. HUMAN T CELLS DO NOT INFILTRATE OR INJURE PIG CORONARY ARTERY GRAFTS IN IMMUNODEFICIENT MOUSE HOSTS. Transplantation 2000, 69: s384. DOI: 10.1097/00007890-200004271-01044.
Interferon-γ elicits arteriosclerosis in the absence of leukocytesTellides G, Tereb D, Kirkiles-Smith N, Kim R, Wilson J, Schechner J, Lorber M, Pober J. Interferon-γ elicits arteriosclerosis in the absence of leukocytes. Nature 2000, 403: 207-211. PMID: 10646607, DOI: 10.1038/35003221.
Coronary artery bypass for advanced left ventricular dysfunctionElefteriades J, Tellides G, Samady H, Yepremyan M, Darr U, Wackers F, Zaret B. Coronary artery bypass for advanced left ventricular dysfunction. 2000, 225: 15-31. DOI: 10.1007/978-0-585-29191-8_2.
Management of descending aortic dissectionElefteriades J, Lovoulos C, Coady M, Tellides G, Kopf G, Rizzo J. Management of descending aortic dissection. The Annals Of Thoracic Surgery 1999, 67: 2002-2005. PMID: 10391358, DOI: 10.1016/s0003-4975(99)00428-2.
LARGE ANIMAL CORONARY ARTERY ENDOTHELIAL EXPRESSION OF MHC MOLECULES IS NOT CONSTITUTIVETereb D, Kirkiles N, Kim R, Pober J, Lorber M, Tellides G. LARGE ANIMAL CORONARY ARTERY ENDOTHELIAL EXPRESSION OF MHC MOLECULES IS NOT CONSTITUTIVE. Transplantation 1999, 67: s591. DOI: 10.1097/00007890-199905150-00217.
Pathogenesis of systemic air embolism during bronchoscopic NdTellides G, Ugurlu B, Kim R, Hammond G. Pathogenesis of systemic air embolism during bronchoscopic Nd. Journal Of Bronchology & Interventional Pulmonology 1999, 6: 126. DOI: 10.1097/00128594-199904000-00021.
VASCULAR REJECTION AFTER ARTERIAL TRANSPLANTATION AND PERIPHERAL LYMPHOID RECONSTITUTION IN SCID MICELorber M, Wilson J, Robert M, Schechner J, Kirkiles N, Quian H, Askenase P, Tellides G, Pober J. VASCULAR REJECTION AFTER ARTERIAL TRANSPLANTATION AND PERIPHERAL LYMPHOID RECONSTITUTION IN SCID MICE. Transplantation 1998, 66: s47. DOI: 10.1097/00007890-199810270-00218.
Pathogenesis of Systemic Air Embolism During Bronchoscopic Nd:YAG Laser OperationsTellides G, Ugurlu B, Kim R, Hammond G. Pathogenesis of Systemic Air Embolism During Bronchoscopic Nd:YAG Laser Operations. The Annals Of Thoracic Surgery 1998, 65: 930-934. PMID: 9564904, DOI: 10.1016/s0003-4975(98)00109-x.
Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting?Mehta I, Weinberg J, Jones M, Tellides G, Kopf G, Shaw R, Zaret B, Elefteriades J. Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting? The Annals Of Thoracic Surgery 1998, 65: 17-23. PMID: 9456088, DOI: 10.1016/s0003-4975(97)01192-2.
Techniques of Skin, Renal, and Vascular Transplantation in the RatDarr U, Tellides G. Techniques of Skin, Renal, and Vascular Transplantation in the Rat. 1998, 73-81. DOI: 10.1007/978-3-642-72140-3_10.
Transplantation Models in Human/Mouse ChimerasTellides G, Kirkiles N, Tereb D, Schechner J, Wilson J, Lorber M, Pober J. Transplantation Models in Human/Mouse Chimeras. 1998, 615-626. DOI: 10.1007/978-3-642-72140-3_63.
Retrosternal ileocolic esophageal replacement in children revisited Antireflux role of the ileocecal valveTouloukian R, Tellides G. Retrosternal ileocolic esophageal replacement in children revisited Antireflux role of the ileocecal valve. Journal Of Thoracic And Cardiovascular Surgery 1994, 107: 1067-1072. PMID: 8159028, DOI: 10.1016/s0022-5223(94)70382-5.
Temporäre Therapie mit monoklonalem Anti-Interleukin-2 Receptor Antikörper induziert Transplantattoleranz nach allogener RattenlebertransplantationGassel H, Engemann R, Tellides G, Morris P. Temporäre Therapie mit monoklonalem Anti-Interleukin-2 Receptor Antikörper induziert Transplantattoleranz nach allogener Rattenlebertransplantation. 1988, 363-366. DOI: 10.1007/978-3-642-73472-4_69.

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George Tellides, MD, PhD

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