Toma Tebaldi, PhD

• Akiko Iwasaki
• Andrew Xiao
• Bluma Lesch
• Diane Krause
• Emanuela Bruscia
• Giulia Biancon
• Huabing Li
• Jonas Christian Schupp
• Jonathan Alderman
• Karla M Neugebauer
• Manoj M Pillai
• Marie Egan
• Matt Simon
• Mina Xu
• Nils Neuenkirchen
• Richard Flavell
• Richard Kibbey
• Rong Fan
• Stephanie Halene
• Thomas Murray
• Vanessa Scanlon
• William Philbrick

Computational Biology; Hematologic Neoplasms

• ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability controlGao Y, Zimmer J, Vasic R, Liu C, Gbyli R, Zheng S, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao A, Slavoff S, Kibbey R, Flavell R, Simon M, Tebaldi T, Li H, Halene S. ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control. Cell Reports 2023, 42: 113163. PMID: 37742191, PMCID: PMC10636609, DOI: 10.1016/j.celrep.2023.113163.
• The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cellsBrina D, Ponzoni A, Troiani M, Calì B, Pasquini E, Attanasio G, Mosole S, Mirenda M, D’Ambrosio M, Colucci M, Guccini I, Revandkar A, Alajati A, Tebaldi T, Donzel D, Lauria F, Parhizgari N, Valdata A, Maddalena M, Calcinotto A, Bolis M, Rinaldi A, Barry S, Rüschoff J, Sabbadin M, Sumanasuriya S, Crespo M, Sharp A, Yuan W, Grinu M, Boyle A, Miller C, Trotman L, Delaleu N, Fassan M, Moch H, Viero G, de Bono J, Alimonti A. The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells. Nature Cancer 2023, 4: 1102-1121. PMID: 37460872, DOI: 10.1038/s43018-023-00594-z.
• Alpha-1 Adrenergic Antagonists Sensitize Neuroblastoma to Therapeutic Differentiation.Broso F, Gatto P, Sidarovich V, Ambrosini C, De Sanctis V, Bertorelli R, Zaccheroni E, Ricci B, Destefanis E, Longhi S, Sebastiani E, Tebaldi T, Adami V, Quattrone A. Alpha-1 Adrenergic Antagonists Sensitize Neuroblastoma to Therapeutic Differentiation. Cancer Research 2023, 83: 2733-2749. PMID: 37289021, DOI: 10.1158/0008-5472.can-22-1913.
• Visualizing gene expression changes in time, space, and single cells with expressyouRcellPaganin M, Tebaldi T, Lauria F, Viero G. Visualizing gene expression changes in time, space, and single cells with expressyouRcell. IScience 2023, 26: 106853. PMID: 37250782, PMCID: PMC10220493, DOI: 10.1016/j.isci.2023.106853.
• TERRA stability is regulated by RALY and polyadenylation in a telomere-specific mannerSavoca V, Rivosecchi J, Gaiatto A, Rossi A, Mosca R, Gialdini I, Zubovic L, Tebaldi T, Macchi P, Cusanelli E. TERRA stability is regulated by RALY and polyadenylation in a telomere-specific manner. Cell Reports 2023, 42: 112406. PMID: 37060569, DOI: 10.1016/j.celrep.2023.112406.
• 3064 – ALKBH5 MODULATES HEMATOPOIETIC STEM AND PROGENITOR CELL ENERGY METABOLISM THROUGH M6A MODIFICATION-MEDIATED RNA STABILITY CONTROLGao Y, Biancon G, Flavell R, Gbyli R, Halene S, Kibbey R, Li H, Li Y, Liu C, Liu W, Nelakanti R, Patel A, Qi Z, Simon M, Slavoff S, Song Y, Tebaldi T, Vasic R, Xiao A, Zheng S, Zimmer J. 3064 – ALKBH5 MODULATES HEMATOPOIETIC STEM AND PROGENITOR CELL ENERGY METABOLISM THROUGH M6A MODIFICATION-MEDIATED RNA STABILITY CONTROL. Experimental Hematology 2023, 124: s82. DOI: 10.1016/j.exphem.2023.06.171.
• 3124 – ANALYSIS OF TRANSCRIPTOMIC AND EPITRANSCRIPTOMIC EFFECTS OF THE ACUTE MEGAKARYOBLASTIC LEUKEMIA FUSION PROTEIN RBM15-MKL1Mayday M, Biancon G, Moratti I, Pintado-Urbanc A, Simon M, Tebaldi T, Halene S, Krause D. 3124 – ANALYSIS OF TRANSCRIPTOMIC AND EPITRANSCRIPTOMIC EFFECTS OF THE ACUTE MEGAKARYOBLASTIC LEUKEMIA FUSION PROTEIN RBM15-MKL1. Experimental Hematology 2023, 124: s111. DOI: 10.1016/j.exphem.2023.06.231.
• Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factorNegro S, Lauria F, Stazi M, Tebaldi T, D’Este G, Pirazzini M, Megighian A, Lessi F, Mazzanti C, Sales G, Romualdi C, Fillo S, Lista F, Sleigh J, Tosolini A, Schiavo G, Viero G, Rigoni M. Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor. Acta Neuropathologica Communications 2022, 10: 189. PMID: 36567321, PMCID: PMC9791753, DOI: 10.1186/s40478-022-01495-5.
• Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosisÖz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.
• Deconvolution of in vivo protein-RNA contacts using fractionated eCLIP-seqBiancon G, Busarello E, Joshi P, Lesch B, Halene S, Tebaldi T. Deconvolution of in vivo protein-RNA contacts using fractionated eCLIP-seq. STAR Protocols 2022, 3: 101823. PMID: 36595959, PMCID: PMC9676202, DOI: 10.1016/j.xpro.2022.101823.
• U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid MalignanciesBiancon G, Busarello E, Lessard M, Courvan E, Escayola D, VanOudenhove J, Lee V, Krick M, Bewersdorf J, Neugebauer K, Tebaldi T, Halene S. U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid Malignancies. Blood 2022, 140: 1271-1272. DOI: 10.1182/blood-2022-170043.
• Harmonizing the Annotation of Hematopoietic Populations in Single-Cell Atlases with the Cell Marker AccordionBusarello E, Ibnat Z, Biancon G, VanOudenhove J, Lauria F, Viero G, Halene S, Tebaldi T. Harmonizing the Annotation of Hematopoietic Populations in Single-Cell Atlases with the Cell Marker Accordion. Blood 2022, 140: 4968-4969. DOI: 10.1182/blood-2022-162180.
• MODL-22. Establishment of a novel system to specifically trace and ablate quiescent/slow cycling cells in high-grade gliomaAntonica F, Santomaso L, Pernici D, Petrucci L, Aiello G, Cutarelli A, Conti L, Romanel A, Miele E, Tebaldi T, Tiberi L. MODL-22. Establishment of a novel system to specifically trace and ablate quiescent/slow cycling cells in high-grade glioma. Neuro-Oncology 2022, 24: i173-i173. DOI: 10.1093/neuonc/noac079.645.
• ALKBH5 Modulates Hematopoietic Stem and Progenitor Cell Energy Metabolism through m 6a Modification-Mediated RNA StabilityGao Y, Zimmer J, Vasic R, Liu C, Gbyli R, Zheng S, Patel A, Wei L, Nelakanti R, Song Y, Biancon G, Xiao A, Slavoff S, Simon M, Flavell R, Tebaldi T, Li H, Halene S. ALKBH5 Modulates Hematopoietic Stem and Progenitor Cell Energy Metabolism through m 6a Modification-Mediated RNA Stability. Blood 2021, 138: 298. DOI: 10.1182/blood-2021-146049.
• U2AF1 Mutations Enhance Stress Granule Response in Myeloid MalignanciesBiancon G, Joshi P, Zimmer J, Hunck T, Gao Y, Lessard M, Courchaine E, Barentine A, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon M, Neugebauer K, Tebaldi T, Halene S. U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies. Blood 2021, 138: 321. DOI: 10.1182/blood-2021-149618.
• Compromised Host Stem Cell Competitiveness Affords Fanconi Stem Cell Engraftment in C-Kit Mutant Humanized MiceWei L, Song Y, Gbyli R, Sefik E, Biancon G, Gao Y, Philbrick W, Patel A, Tebaldi T, Nalepa G, Kupfer G, Flavell R, Halene S. Compromised Host Stem Cell Competitiveness Affords Fanconi Stem Cell Engraftment in C-Kit Mutant Humanized Mice. Blood 2021, 138: 1119. DOI: 10.1182/blood-2021-153777.
• Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORSWu X, Niculite C, Preda M, Rossi A, Tebaldi T, Butoi E, White M, Tudoran O, Petrusca D, Jannasch A, Bone W, Zong X, Fang F, Burlacu A, Paulsen M, Hancock B, Sandusky G, Mitra S, Fishel M, Buechlein A, Ivan C, Oikonomopoulos S, Gorospe M, Mosley A, Radovich M, Davé U, Ragoussis J, Nephew K, Mari B, McIntyre A, Konig H, Ljungman M, Cousminer D, Macchi P, Ivan M. Publisher Correction: Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS. Nature Communications 2020, 11: 5737. PMID: 33159065, PMCID: PMC7648073, DOI: 10.1038/s41467-020-19708-7.
• Reconstruction of Sickle Cell Disease with Circulating Sickling Red Blood Cells in Novel Humanized Cytokines and Liver Mistrg MiceSong Y, Gbyli R, Shan L, Liu W, Gao Y, Patel A, Fu X, Wang X, Xu M, Qin A, Bruscia E, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Gonzales D, Krause D, Alderman J, Flavell R, Halene S. Reconstruction of Sickle Cell Disease with Circulating Sickling Red Blood Cells in Novel Humanized Cytokines and Liver Mistrg Mice. Blood 2020, 136: 29-30. DOI: 10.1182/blood-2020-141603.
• High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid MalignanciesBiancon G, Joshi P, Hunck T, Zimmer J, Gao Y, Machyna M, Botti V, Qin A, Viero G, Neuenkirchen N, Taylor A, Gbyli R, Patel A, Ardasheva A, Fu X, Lin H, Simon M, Neugebauer K, Tebaldi T, Halene S. High-Resolution Binding Atlas of U2AF1 Mutants Uncovers New Complexity in Splicing Alterations and Kinetics in Myeloid Malignancies. Blood 2020, 136: 3-4. DOI: 10.1182/blood-2020-142854.
• A Computing System for Discovering Causal Relationships Among Human Genes to Improve Drug RepositioningBlanzieri E, Tebaldi T, Cavecchia V, Asnicar F, Masera L, TomÈ G, Nigro E, Colasurdo E, Ciciani M, Mazzoni C, Pilati S. A Computing System for Discovering Causal Relationships Among Human Genes to Improve Drug Repositioning. IEEE Transactions On Emerging Topics In Computing 2020, 9: 1667-1682. DOI: 10.1109/tetc.2020.3031024.
• Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic FailureGao Y, Vasic R, Song Y, Teng R, Gbyli R, Biancon G, Nelakanti R, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Dura B, Lee V, Viero G, Iwasaki A, Fan R, Xiao A, Flavell R, Li H, Tebaldi T, Halene S. Loss of METTL3 Mediated m6A RNA Modification Results in Double-Stranded RNA Induced Innate Immune Response and Hematopoietic Failure. Blood 2019, 134: 450. DOI: 10.1182/blood-2019-130442.
• PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH InhibitorsGbyli R, Song Y, Liu W, Gao Y, Chandhok N, Fu X, Wang X, Patel A, Sundaram R, Tebaldi T, Biancon G, Ardasheva A, Qin A, Sadykov M, Mamillapalli P, Flavell R, Prebet T, Bindra R, Halene S. PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors. Blood 2019, 134: 4222. DOI: 10.1182/blood-2019-130814.
• U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA ComplexBiancon G, Joshi P, Hunck T, Gao Y, Botti V, Qin A, Sadykov M, Wang X, Viero G, Neuenkirchen N, Taylor A, Huang J, Ardasheva A, Fu X, Lin H, Pillai M, Kielkopf C, Neugebauer K, Tebaldi T, Halene S. U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA Complex. Blood 2019, 134: 1230. DOI: 10.1182/blood-2019-130759.
• In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg MiceSong Y, Shan L, Gbyli R, Liu W, Fu X, Wang X, Qin A, Patel A, Gao Y, Tebaldi T, Biancon G, Urbonas D, Alderman J, Halene S, Flavell R. In Vivo reconstruction of Human Erythropoiesis with Circulating Mature Human RBCs in Humanized Liver Mistrg Mice. Blood 2019, 134: 338. DOI: 10.1182/blood-2019-130701.
• Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and MiceXavier-Ferrucio J, Li X, Scanlon V, Zhang P, Ayala-Lopez N, Tebaldi T, Halene S, Finberg K, Krause D. Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and Mice. Blood 2018, 132: 2. DOI: 10.1182/blood-2018-99-115124.
• Mettl3 Mediated m6A Modification Is Essential in Fetal HematopoiesisGao Y, Vasic R, Tebaldi T, Song Y, Teng R, Joshi P, Viero G, Xiao A, Batista P, Li H, Flavell R, Halene S. Mettl3 Mediated m6A Modification Is Essential in Fetal Hematopoiesis. Blood 2018, 132: 3825. DOI: 10.1182/blood-2018-99-119699.
• Integrative Genome-Wide Analysis of RNA Binding and Splicing Reveals Complex Loss and Gain of Function Alterations By SRSF2 P95 Mutations in MyelodysplasiaRejeski K, Liang Y, Tebaldi T, Stefani G, Taylor A, Maziarz J, Song Y, Balasubramanian K, Vasic R, Kapetanovic E, Abdel-Wahab O, Pillai M, Halene S. Integrative Genome-Wide Analysis of RNA Binding and Splicing Reveals Complex Loss and Gain of Function Alterations By SRSF2 P95 Mutations in Myelodysplasia. Blood 2015, 126: 141. DOI: 10.1182/blood.v126.23.141.141.
• 22 MUTATIONS IN SRSF2 IDENTIFIED IN MYELODYSPLASIA AFFECT RNA BINDING AFFINITY, SPECIFICITY, AND SPLICINGLiang Y, Daubner G, Tebaldi T, Li Y, Stefani G, Taylor A, Maziarz J, Rejeski K, Vasic R, Modis Y, Allain F, Halene S. 22 MUTATIONS IN SRSF2 IDENTIFIED IN MYELODYSPLASIA AFFECT RNA BINDING AFFINITY, SPECIFICITY, AND SPLICING. Leukemia Research 2015, 39: s9-s10. DOI: 10.1016/s0145-2126(15)30023-0.
• Abstract 1408: p53-directed translational control can shape and expand the universe of p53 target genesZaccara S, Tebaldi T, Ciribilli Y, Bisio A, Inga A. Abstract 1408: p53-directed translational control can shape and expand the universe of p53 target genes. 2014, 1408-1408. DOI: 10.1158/1538-7445.am2014-1408.
• 282: p53-directed translational control can shape and expand the universe of p53 target genesZaccara S, Bolado C, Pederiva C, Tebaldi T, Ciribilli Y, Bisio A, Inga A. 282: p53-directed translational control can shape and expand the universe of p53 target genes. European Journal Of Cancer 2014, 50: s66-s67. DOI: 10.1016/s0959-8049(14)50250-x.
• p53-directed translational control can shape and expand the universe of p53 target genesZaccara S, Tebaldi T, Pederiva C, Ciribilli Y, Bisio A, Inga A. p53-directed translational control can shape and expand the universe of p53 target genes. Cell Death & Differentiation 2014, 21: 1522-1534. PMID: 24926617, PMCID: PMC4158691, DOI: 10.1038/cdd.2014.79.
• Abstract 746: Functional crosstalk between the p53 and NF-kB transcription factors.Bisio A, Zámborszky J, Zaccara S, Lion M, Tebaldi T, Ciribilli Y, Inga A. Abstract 746: Functional crosstalk between the p53 and NF-kB transcription factors. Cancer Research 2013, 73: 746-746. DOI: 10.1158/1538-7445.am2013-746.
• 107 Multi-level Gene Expression Regulation Effects of the NAMPT Inhibitor FK866 in a Model of Acute T Cell LeukemiaZucal C, D'Agostino V, Tebaldi T, Sociali G, Bruzzone S, Quattrone A, Nencioni A, Provenzani A. 107 Multi-level Gene Expression Regulation Effects of the NAMPT Inhibitor FK866 in a Model of Acute T Cell Leukemia. European Journal Of Cancer 2012, 48: 33-34. DOI: 10.1016/s0959-8049(12)71905-6.
• 660 Functional Crosstalk Between the P53 and NF-kB Transcription FactorsZamborszky J, Zaccara S, Bisio A, Lion M, Tebaldi T, Ciribilli Y, Inga A. 660 Functional Crosstalk Between the P53 and NF-kB Transcription Factors. European Journal Of Cancer 2012, 48: s156. DOI: 10.1016/s0959-8049(12)71306-0.
• 302 Transcriptional Cooperation Between p53 and Estrogen Receptors in a Breast Cancer ModelLion M, Bisio A, De Sanctis V, Ciribilli Y, Tebaldi T, Menendez D, Resnick M, Inga A. 302 Transcriptional Cooperation Between p53 and Estrogen Receptors in a Breast Cancer Model. European Journal Of Cancer 2012, 48: s74. DOI: 10.1016/s0959-8049(12)70996-6.
• AURA: Atlas of UTR Regulatory ActivityDassi E, Malossini A, Re A, Mazza T, Tebaldi T, Caputi L, Quattrone A. AURA: Atlas of UTR Regulatory Activity. Bioinformatics 2011, 28: 142-144. PMID: 22057158, DOI: 10.1093/bioinformatics/btr608.