Thomas Murray, MD, PhD
Research & Publications
Biography
News
Research Summary
Children with the genetic disease Cystic Fibrosis get multiple lung infections with a bacteria called Pseudomonas aeruginosa. These infections lead to frequent hospitalizations and a decreased quality of life for these children. Pseudomonas infections are difficult to treat because the bacteria form organized communities called biofilms that are often resistant to antibiotics. Dr Murray’s research focuses on understanding the optimal methods to disinfect home respiratory equipment that can be contaminated with Psreudomonas and other bacteria. Dr Murray also studies how the immune system in CF is altered when it interacts with Pseudomonas and is collaborating with Dr Emanuela Bruscia to study drugs that improve the immune response to bacteria for CF patients. The long term goal of this work is to find a fast, easy, relaibel disinfection method for families with CF and study novel drugs that may help treat and prevent CF lung infections and the inflammation that is involved. He also studies how to reduce the risk of infection for hospitalized children with an emphasis on disinfection of hospital equipment and improving infection prevention practices for both staff and families
Extensive Research Description
Pulmonary infection in cystic fibrosis (CF): Prevention, pathogenesis and treatment
Global Aim: Identify optimal methods to prevent and treat pulmonary infections in children with CF. There are two arms of the research program:1) Understanding the host/pathogen interaction and inflammation in CF; 2) Disinfection and infection prevention in the CF home and in the community
1) Understanding the host/pathogen interaction and inflammation in CF.
Increased inflammation in the CF lung contributes to premature patient morbidity and mortality. Both chronic infection and underlying dysfunction of the immune system in CF are fundamental to this increased inflammation. Heme-oygenase (HO), an enzyme that activates anti-inflammatory and anti-microbial cellular responses, is reduced in CF. Dr. Emanuela Bruscia and I are leading a team that is testing potential therapies (see below) to restore HO activity and reduce inflammation to normal levels. Furthermore, we are studying the interaction between Pseudomonas aeruginosa, a common CF pulmonary pathogen, and CF host cells to understand how chronic infection prevents the resolution of inflammation.
This work involves a novel drug, Sanguinate (Prolong pharmaceuticals), bovine hemoglobin saturated with carbon monoxide, as a potent anti-inflammatory and anti-microbial drug that, in vitro, can reduce the hyper-inflammation observed in CF macrophages via correcting the reduced expression of the
HO pathway. Future work will study whether Sanguinate has in vivo antimicrobial and anti-inflammatory properties in animal models of pulmonary infection. If successful, these studies will lay the groundwork for potential clinical trials partnering with the Cystic Fibrosis Foundation Therapeutic Drug Network.
2) Disinfection and infection prevention in the CF home and community.
The burden of home care for children and families with CF is extensive, requiring multiple daily treatments. Home respiratory equipment can be contaminated with lung pathogens, providing a potential source of re-infection with each nebulization. I have studied how different home disinfection techniques kill common CF bacterial pathogens on nebulizers and whether repeated disinfection with these methods changes nebulizer function. Recently, this disinfection research has extended beyond CF to the community, studying bacterial contamination from hand dryers in bathrooms to determine optimal hand drying techniques.
Future questions regarding infection prevention that my team is working on include: 1) What is the risk to patients for aerosolizing bacteria on home nebulizer equipment? Few studies have examined the factors, (e.g. biofilm formation, hydration) that impact bacterial dispersion during nebulization. 2) Do all disinfection methods work equally well on clinical isolates? We will test clinical CF bacterial isolates under different disinfection conditions to determine the preferred method. 3) Do user friendly disinfection methods result in improved patient quality of life? We will measure compliance and the burden of home care for different disinfection methods. We anticipate that the results of these studies will be generalizable beyond the CF population and impact families with other diseases that require home nebulizers. I continue to study infection prevention in the community comparing bacterial contamination from different hand drying methods, forced air hand dryers or paper towels, with a focus on anaerobic bacteria including Clostridium difficile. This work will help determine best practice hand drying techniques.
Coauthors
Research Interests
Pediatrics
Public Health Interests
Antimicrobial Resistance; Disease Transmission; Infectious Diseases
Research Image
Selected Publications
- 93 Persistent airway infections in cystic fibrosis–like mouse models correlate with phenotypic changes of clinical Pseudomonas aeruginosa isolatesOez H, Braga C, Laurence E, Gudneppanavar R, Huang P, Zhang P, Egan M, Bruscia E, Murray T. 93 Persistent airway infections in cystic fibrosis–like mouse models correlate with phenotypic changes of clinical Pseudomonas aeruginosa isolates. Journal Of Cystic Fibrosis 2023, 22: s48. DOI: 10.1016/s1569-1993(23)01028-7.
- 361 Chronic lung inflammation abrogates quiescent state of hematopoietic stem cells in a cystic fibrosis mouse modelBraga C, Mancuso R, Thompson E, Oez H, Gudneppanavar R, Zhang P, Huang P, Murray T, Egan M, Krause D, Bruscia E. 361 Chronic lung inflammation abrogates quiescent state of hematopoietic stem cells in a cystic fibrosis mouse model. Journal Of Cystic Fibrosis 2023, 22: s183. DOI: 10.1016/s1569-1993(23)01288-2.
- 220 Ezrin is required to maintain the number and function of tissue resident alveolar macrophages in cystic fibrosis during infectionGudneppanavar R, Di Pietro C, Oez H, Zhang P, Huang P, Britto-Leon C, Krause D, Egan M, Murray T, Bruscia E. 220 Ezrin is required to maintain the number and function of tissue resident alveolar macrophages in cystic fibrosis during infection. Journal Of Cystic Fibrosis 2023, 22: s113. DOI: 10.1016/s1569-1993(23)01150-5.
- Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic.Barrett R, Fleiss N, Hansen C, Campbell M, Rychalsky M, Murdzek C, Krechevsky K, Abbott M, Allegra T, Blazevich B, Dunphy L, Fox A, Gambardella T, Garcia L, Grimm N, Scoffone A, Bizzarro M, Murray T. Reducing MRSA Infection in a New NICU During the COVID-19 Pandemic. Pediatrics 2023, 151 PMID: 36625072, DOI: 10.1542/peds.2022-057033.
- Masking in early child care and COVID-19 infectionMurray T, Malik A, Gilliam W. Masking in early child care and COVID-19 infection. TheScienceBreaker 2022, 8 DOI: 10.25250/thescbr.brk665.
- Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey StudyRoberts S, Havill N, Flores RM, Hendrix C, Williams MJ, Feinn RS, Choi SJ, Martinello RA, Marks AM, Murray TS. Disinfection of Virtual Reality Devices in Health Care Settings: In Vitro Assessment and Survey Study. Journal Of Medical Internet Research 2022, 24: e42332. PMID: 36269222, PMCID: PMC9756115, DOI: 10.2196/42332.
- Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosisÖz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis. Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.
- 455 Impaired recruitment of C-C motif chemokine receptor 2-positive monocytes does not compromise host defense against pulmonary Pseudomonas aeruginosa infectionsÖz H, Di Pietro C, Rodrigues G, Zhang P, Huang P, Egan M, Murray T, Bruscia E. 455 Impaired recruitment of C-C motif chemokine receptor 2-positive monocytes does not compromise host defense against pulmonary Pseudomonas aeruginosa infections. Journal Of Cystic Fibrosis 2022, 21: s260. DOI: 10.1016/s1569-1993(22)01145-6.
- 674 Loss of functional cystic fibrosis transmembrane conductance regulator leads to a calpain-dependent degradation of ezrin in activated cystic fibrosis macrophagesDi Pietro C, Öz H, Rodrigues G, Huang P, Zhang P, Murray T, Egan M, Bruscia E. 674 Loss of functional cystic fibrosis transmembrane conductance regulator leads to a calpain-dependent degradation of ezrin in activated cystic fibrosis macrophages. Journal Of Cystic Fibrosis 2022, 21: s369. DOI: 10.1016/s1569-1993(22)01364-9.
- 491 Pel overexpression by Pseudomonas aeruginosa reduces induction of heme-oxygenase 1 in macrophagesRodrigues G, Di Pietro C, Huang P, Öz H, Bruscia E, Murray T. 491 Pel overexpression by Pseudomonas aeruginosa reduces induction of heme-oxygenase 1 in macrophages. Journal Of Cystic Fibrosis 2022, 21: s278. DOI: 10.1016/s1569-1993(22)01181-x.
- Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 PandemicElharake JA, Shafiq M, Cobanoglu A, Malik AA, Klotz M, Humphries JE, Murray T, Patel KM, Wilkinson D, Yildirim I, Diaz R, Rojas R, Cohen A, Lee A, Omer SB, Gilliam WS. Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic. Preventing Chronic Disease 2022, 19: e61. PMID: 36137183, PMCID: PMC9541678, DOI: 10.5888/pcd19.220132.
- Implementation of Pre-Admission Caregiver Testing for COVID-19.He M, Peaper DR, Murray T, Ciaburri R, Doyle J, Loyal J. Implementation of Pre-Admission Caregiver Testing for COVID-19. Hospital Pediatrics 2022, 12: e326-e329. PMID: 36047308, DOI: 10.1542/hpeds.2022-006715.
- Relationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort studyPatel KM, Shafiq M, Malik AA, Cobanoglu A, Klotz M, Eric Humphries J, Lee A, Murray T, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Rojas R, Kuperwajs Cohen A, Omer SB, Gilliam WS. Relationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort study. Vaccine 2022, 40: 4098-4104. PMID: 35660329, PMCID: PMC9135692, DOI: 10.1016/j.vaccine.2022.05.064.
- Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosisDi Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis. Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.
- A mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectantsRoberts SC, Hendrix CA, Edwards LM, Feinn RS, Martinello RA, Murray TS. A mixed-methods evaluation on the efficacy and perceptions of needleless connector disinfectants. Infection Control And Hospital Epidemiology 2022, 44: 230-233. PMID: 35387702, PMCID: PMC9929708, DOI: 10.1017/ice.2022.72.
- Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis InfectionZhao A, Butala N, Luc CM, Feinn R, Murray TS. Telehealth Reduces Missed Appointments in Pediatric Patients with Tuberculosis Infection. Tropical Medicine And Infectious Disease 2022, 7: 26. PMID: 35202221, PMCID: PMC8877294, DOI: 10.3390/tropicalmed7020026.
- Bacterial Surface Detachment during Nebulization with Contaminated Reusable Home NebulizersHarris JC, Collins MS, Huang PH, Schramm CM, Nero T, Yan J, Murray TS. Bacterial Surface Detachment during Nebulization with Contaminated Reusable Home Nebulizers. Microbiology Spectrum 2022, 10: e02535-21. PMID: 35107362, PMCID: PMC8809330, DOI: 10.1128/spectrum.02535-21.
- Association of Child Masking With COVID-19–Related Closures in US Childcare ProgramsMurray TS, Malik AA, Shafiq M, Lee A, Harris C, Klotz M, Humphries JE, Patel KM, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Reyes C, Omer SB, Gilliam WS. Association of Child Masking With COVID-19–Related Closures in US Childcare Programs. JAMA Network Open 2022, 5: e2141227. PMID: 35084484, PMCID: PMC8796014, DOI: 10.1001/jamanetworkopen.2021.41227.
- COVID-19 Vaccine Uptake Among US Child Care ProvidersPatel KM, Malik AA, Lee A, Klotz M, Humphries JE, Murray T, Wilkinson D, Shafiq M, Yildirim I, Elharake JA, Diaz R, Reyes C, Omer SB, Gilliam WS. COVID-19 Vaccine Uptake Among US Child Care Providers. Pediatrics 2021, 148: e2021053813. PMID: 34452977, PMCID: PMC9277775, DOI: 10.1542/peds.2021-053813.
- 558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosisPietro C, Öz H, Zhang P, Cheng E, Martis V, Bonfield T, Kelley T, Jubin R, Abuchowski A, Krause D, Egan M, Murray T, Bruscia E. 558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosis. Journal Of Cystic Fibrosis 2021, 20: s263-s264. DOI: 10.1016/s1569-1993(21)01981-0.
- 473: Impairing the recruitment of inflammatory monocytes to CF lungs does not weaken host defense against pulmonary Pseudomonas aeruginosa infectionsÖz H, Di Pietro C, Cheng E, Zhang P, Huang P, Murray T, Egan M, Bruscia E. 473: Impairing the recruitment of inflammatory monocytes to CF lungs does not weaken host defense against pulmonary Pseudomonas aeruginosa infections. Journal Of Cystic Fibrosis 2021, 20: s223. DOI: 10.1016/s1569-1993(21)01897-x.
- Persistent Leg Drainage in a Pediatric Trauma Patient.Howard A, Rychalsky MR, Murray TS. Persistent Leg Drainage in a Pediatric Trauma Patient. The Pediatric Infectious Disease Journal 2021, 40: 597-599. PMID: 33956759, DOI: 10.1097/INF.0000000000003004.
- Mass severe acute respiratory coronavirus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel – ERRATUMRoberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel – ERRATUM. Infection Control And Hospital Epidemiology 2021, 43: 1312-1312. PMID: 33779533, PMCID: PMC9981472, DOI: 10.1017/ice.2021.107.
- Mass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnelRoberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel. Infection Control And Hospital Epidemiology 2021, 42: 1-2. PMID: 33487206, PMCID: PMC7853752, DOI: 10.1017/ice.2021.9.
- COVID-19 Transmission in US Child Care ProgramsGilliam WS, Malik AA, Shafiq M, Klotz M, Reyes C, Humphries JE, Murray T, Elharake JA, Wilkinson D, Omer SB. COVID-19 Transmission in US Child Care Programs. Pediatrics 2021, 147: e2020031971. PMID: 33055228, DOI: 10.1542/peds.2020-031971.
- Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic.Peaper DR, Murdzek C, Oliveira CR, Murray TS. Severe Acute Respiratory Syndrome Coronavirus 2 Testing in Children in a Large Regional US Health System During the Coronavirus Disease 2019 Pandemic. The Pediatric Infectious Disease Journal 2020, 40: 175-181. PMID: 33399431, PMCID: PMC8852689, DOI: 10.1097/inf.0000000000003024.
- Unmasking symptomatic dermatographism in the time of COVID-19Wong KH, Murray T, Osborn R, Soffer GK. Unmasking symptomatic dermatographism in the time of COVID-19. Postgraduate Medical Journal 2020, 97: 402-402. PMID: 32913035, PMCID: PMC10016992, DOI: 10.1136/postgradmedj-2020-138688.
- Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic FibrosisDi Pietro C, Öz HH, Murray TS, Bruscia EM. Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis. Frontiers In Pharmacology 2020, 11: 1059. PMID: 32760278, PMCID: PMC7372134, DOI: 10.3389/fphar.2020.01059.
- Oxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipesColandrea NA, Cleary ML, Peaper DR, Sullivan LK, Martinello RA, Murray TS. Oxygen nipple and nut (Christmas tree) adaptor contamination rates and decontamination with disinfecting wipes. Infection Control And Hospital Epidemiology 2020, 41: 396-399. PMID: 31983357, DOI: 10.1017/ice.2020.9.
- Shifting focus toward healthcare-associated bloodstream infections: The need for neonatal intensive care unit–specific NHSN definitionsAdvani SD, Murray TS, Murdzek CM, Aniskiewicz MJ, Bizzarro MJ. Shifting focus toward healthcare-associated bloodstream infections: The need for neonatal intensive care unit–specific NHSN definitions. Infection Control And Hospital Epidemiology 2019, 41: 181-186. PMID: 31694731, DOI: 10.1017/ice.2019.310.
- 585. Shifting Focus Toward Healthcare-Associated Bloodstream Infections: Need for More NICU-Specific NHSN DefinitionsAdvani S, Murray T, Bizzarro M. 585. Shifting Focus Toward Healthcare-Associated Bloodstream Infections: Need for More NICU-Specific NHSN Definitions. Open Forum Infectious Diseases 2019, 6: s276-s277. PMCID: PMC6810847, DOI: 10.1093/ofid/ofz360.654.
- Nebulizer cleaning and disinfection practices in families with cystic fibrosis: The relationship between attitudes, practice and microbe colonizationMurray TS, O'Rourke TK, Feinn R, Drapeau G, Collins MS. Nebulizer cleaning and disinfection practices in families with cystic fibrosis: The relationship between attitudes, practice and microbe colonization. Journal Of Cystic Fibrosis 2019, 18: 823-828. PMID: 31126899, DOI: 10.1016/j.jcf.2019.05.008.
- Targeting the HO-1/CO Pathway with Sanguinate: Toward Development of a Novel Anti-inflammatory Therapy for Cystic Fibrosis (CF) Lung DiseaseDi Pietro C, Oz H, Martis V, Zhang P, Jubin R, Abuchowski A, Krause D, Egan M, Murray T, Bruscia E. Targeting the HO-1/CO Pathway with Sanguinate: Toward Development of a Novel Anti-inflammatory Therapy for Cystic Fibrosis (CF) Lung Disease. 2019, a6187-a6187. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6187.
- Repeated hot water and steam disinfection of pari LC Plus® nebulizers alters nebulizer outputCollins MS, Murray TS. Repeated hot water and steam disinfection of pari LC Plus® nebulizers alters nebulizer output. Journal Of Cystic Fibrosis 2019, 18: e17-e18. PMID: 30792172, DOI: 10.1016/j.jcf.2019.01.014.
- Fungal PneumoniaMurray T, Girotto J, Bennett N. Fungal Pneumonia. 2019, 95-106. DOI: 10.1007/978-3-319-91080-2_9.
- The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship ProgramsMurray TS, Herbst J. The Ethics of Fecal Microbiota Transplant as a Tool for Antimicrobial Stewardship Programs. The Journal Of Law, Medicine & Ethics 2019, 47: 541-554. PMID: 31957576, DOI: 10.1177/1073110519897730.
- Repeated hot water and steam disinfection of Pari LC Plus® nebulizers alter nebulizer outputCollins MS, O'Brien M, Schramm CM, Murray TS. Repeated hot water and steam disinfection of Pari LC Plus® nebulizers alter nebulizer output. Journal Of Cystic Fibrosis 2018, 18: 233-235. PMID: 30224332, DOI: 10.1016/j.jcf.2018.08.005.
- Deposition of Bacteria and Bacterial Spores by Bathroom Hot-Air Hand Dryersdel Carmen Huesca-Espitia L, Aslanzadeh J, Feinn R, Joseph G, Murray TS, Setlow P. Deposition of Bacteria and Bacterial Spores by Bathroom Hot-Air Hand Dryers. Applied And Environmental Microbiology 2018, 84: e00044-18. PMID: 29439992, PMCID: PMC5881072, DOI: 10.1128/aem.00044-18.
- Ozone disinfection of home nebulizers effectively kills common cystic fibrosis bacterial pathogensTowle D, Baker V, Schramm C, O'Brien M, Collins MS, Feinn R, Murray TS. Ozone disinfection of home nebulizers effectively kills common cystic fibrosis bacterial pathogens. Pediatric Pulmonology 2018, 53: 599-604. PMID: 29542874, DOI: 10.1002/ppul.23990.
- Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophagesDi Pietro C, Zhang PX, O’Rourke T, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages. Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.
- A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal SpeciesVivar S, Girotto JE, Murray TS. A Dual Case of Peritonitis and Central Nervous System Infection Caused by Nutritionally Variant Streptococcal Species. Case Reports In Infectious Diseases 2017, 2017: 6012964. PMID: 28239499, PMCID: PMC5292362, DOI: 10.1155/2017/6012964.
- The Approach to Pseudomonas aeruginosa in Cystic FibrosisTalwalkar JS, Murray TS. The Approach to Pseudomonas aeruginosa in Cystic Fibrosis. Clinics In Chest Medicine 2016, 37: 69-81. PMID: 26857769, DOI: 10.1016/j.ccm.2015.10.004.
- 5 Introduction to the Laboratory Diagnosis of Infectious DiseasesMurray T, Haycocks N, Fink S. 5 Introduction to the Laboratory Diagnosis of Infectious Diseases. 2016, 94-102. DOI: 10.1016/b978-0-323-28945-0.00005-3.
- 2 Bacteriology of the Head and Neck RegionsMurray T, Cassese T. 2 Bacteriology of the Head and Neck Regions. 2016, 27-37. DOI: 10.1016/b978-0-323-28945-0.00002-8.
- Sinus Disease in Cystic FibrosisCollins M, Murray T, Rizzi M. Sinus Disease in Cystic Fibrosis. 2016, 121-133. DOI: 10.1007/978-3-319-21744-4_9.
- Baby bottle steam sterilizers for disinfecting home nebulizers inoculated with non-tuberculous mycobacteriaTowle D, Callan DA, Lamprea C, Murray TS. Baby bottle steam sterilizers for disinfecting home nebulizers inoculated with non-tuberculous mycobacteria. Journal Of Hospital Infection 2015, 92: 222-225. PMID: 26810616, DOI: 10.1016/j.jhin.2015.08.030.
- The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in childrenMurray TS, Peaper DR. The contribution of extended-spectrum &bgr;-lactamases to multidrug-resistant infections in children. Current Opinion In Pediatrics 2015, 27: 124-131. PMID: 25565574, DOI: 10.1097/mop.0000000000000182.
- ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia.Somily AM, Habib HA, Absar MM, Arshad MZ, Manneh K, Al Subaie SS, Al Hedaithy MA, Sayyed SB, Shakoor Z, Murray TS. ESBL-producing Escherichia coli and Klebsiella pneumoniae at a tertiary care hospital in Saudi Arabia. The Journal Of Infection In Developing Countries 2014, 8: 1129-36. PMID: 25212077, DOI: 10.3855/jidc.4292.
- Navigating the Pediatric Microbiome: Emerging Evidence and Clinical ImplicationsKassam Z, Murray T. Navigating the Pediatric Microbiome: Emerging Evidence and Clinical Implications. Current Pediatrics Reports 2014, 2: 93-101. DOI: 10.1007/s40124-014-0040-1.
- Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass SpectrometryKulkarni MV, Zurita AN, Pyka JS, Murray TS, Hodsdon ME, Peaper DR. Use of Imipenem To Detect KPC, NDM, OXA, IMP, and VIM Carbapenemase Activity from Gram-Negative Rods in 75 Minutes Using Liquid Chromatography-Tandem Mass Spectrometry. Journal Of Clinical Microbiology 2014, 52: 2500-2505. PMID: 24789180, PMCID: PMC4097713, DOI: 10.1128/jcm.00547-14.
- Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role?Somily AM, Alsubaie SS, BinSaeed AA, Torchyan AA, Alzamil FA, Al-Aska AI, Al-Khattaf FS, Khalifa LA, Al-Thawadi SI, Alaidan AA, Al-Ahdal MN, Al-Qahtani AA, Murray TS. Extended-spectrum β-lactamase-producing Klebsiella pneumoniae in the neonatal intensive care unit: Does vancomycin play a role? American Journal Of Infection Control 2014, 42: 277-282. PMID: 24581016, DOI: 10.1016/j.ajic.2013.09.028.
- Mentoring program design and implementation in new medical schoolsFornari A, Murray TS, Menzin AW, Woo VA, Clifton M, Lombardi M, Shelov S. Mentoring program design and implementation in new medical schools. Medical Education Online 2014, 19: 24570. PMID: 24962112, PMCID: PMC4069409, DOI: 10.3402/meo.v19.24570.
- Brucella spp isolated from respiratory sample and grown in Mycobacterium growth indicator tube (MGIT)Somily AM, Kambal AM, Naeem T, Babay HA, Hedaithy M, Anazi A, Barry MA, Aska A, Morshed MG, Murray TS. Brucella spp isolated from respiratory sample and grown in Mycobacterium growth indicator tube (MGIT). Annals Of Saudi Medicine 2013, 33: 394-396. PMID: 24060721, PMCID: PMC6078500, DOI: 10.5144/0256-4947.2013.394.
- Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance RegulatorZhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator. The Journal Of Immunology 2013, 190: 5196-5206. PMID: 23606537, PMCID: PMC3711148, DOI: 10.4049/jimmunol.1201607.
- Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MSPeaper DR, Kulkarni MV, Tichy AN, Jarvis M, Murray TS, Hodsdon ME. Rapid detection of carbapenemase activity through monitoring ertapenem hydrolysis in Enterobacteriaceae with LCMS/MS. Bioanalysis 2013, 5: 147-157. PMID: 23330558, PMCID: PMC5753620, DOI: 10.4155/bio.12.310.
- Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogensTowle D, Callan DA, Farrel PA, Egan ME, Murray TS. Baby bottle steam sterilizers disinfect home nebulizers inoculated with bacterial respiratory pathogens. Journal Of Cystic Fibrosis 2012, 12: 512-516. PMID: 23267773, DOI: 10.1016/j.jcf.2012.11.013.
- The GTPase Activity of FlhF Is Dispensable for Flagellar Localization, but Not Motility, in Pseudomonas aeruginosaSchniederberend M, Abdurachim K, Murray TS, Kazmierczak BI. The GTPase Activity of FlhF Is Dispensable for Flagellar Localization, but Not Motility, in Pseudomonas aeruginosa. Journal Of Bacteriology 2012, 195: 1051-1060. PMID: 23264582, PMCID: PMC3571332, DOI: 10.1128/jb.02013-12.
- Chronic versus Acute Pseudomonas aeruginosa Infection StatesKazmierczak B, Murray T. Chronic versus Acute Pseudomonas aeruginosa Infection States. 2012, 21-39. DOI: 10.1128/9781555818524.ch2.
- The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized PatientsLedizet M, Murray TS, Puttagunta S, Slade MD, Quagliarello VJ, Kazmierczak BI. The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients. PLOS ONE 2012, 7: e49578. PMID: 23152923, PMCID: PMC3495863, DOI: 10.1371/journal.pone.0049578.
- Comparison of Disk Diffusion and Etest Methods to Determine the Susceptibility of Staphylococcus aureus Circulating in Riyadh, Saudi Arabia to Fusidic AcidSomily AM, Peaper DR, Paintsil E, Murray TS. Comparison of Disk Diffusion and Etest Methods to Determine the Susceptibility of Staphylococcus aureus Circulating in Riyadh, Saudi Arabia to Fusidic Acid. International Journal Of Microbiology 2012, 2012: 391251. PMID: 22888356, PMCID: PMC3409531, DOI: 10.1155/2012/391251.
- Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline.Somily AM, Absar MM, Arshad MZ, Al Aska AI, Shakoor ZA, Fatani AJ, Siddiqui YM, Murray TS. Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline. Saudi Medical Journal 2012, 33: 750-5. PMID: 22821309.
- The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm FormationMurray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation. PLOS ONE 2012, 7: e35499. PMID: 22563385, PMCID: PMC3338523, DOI: 10.1371/journal.pone.0035499.
- Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut VeteransFink SL, Martinello RA, Campbell SM, Murray TS. Low Prevalence of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates among Connecticut Veterans. Antimicrobial Agents And Chemotherapy 2011, 56: 582-583. PMID: 22064529, PMCID: PMC3256079, DOI: 10.1128/aac.05024-11.
- Relapse of polymicrobial endocarditis in an intravenous drug user.Wang’ondu R, Murray TS. Relapse of polymicrobial endocarditis in an intravenous drug user. The Yale Journal Of Biology And Medicine 2011, 84: 321-4. PMID: 21966051, PMCID: PMC3178863.
- Microbiota regulates immune defense against respiratory tract influenza A virus infectionIchinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, Iwasaki A. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5354-5359. PMID: 21402903, PMCID: PMC3069176, DOI: 10.1073/pnas.1019378108.
- Lyme DiseaseMurray TS, Shapiro ED. Lyme Disease. Clinics In Laboratory Medicine 2010, 30: 311-328. PMID: 20513553, PMCID: PMC3652387, DOI: 10.1016/j.cll.2010.01.003.
- Swarming motility, secretion of type 3 effectors and biofilm formation phenotypes exhibited within a large cohort of Pseudomonas aeruginosa clinical isolatesMurray TS, Ledizet M, Kazmierczak BI. Swarming motility, secretion of type 3 effectors and biofilm formation phenotypes exhibited within a large cohort of Pseudomonas aeruginosa clinical isolates. Journal Of Medical Microbiology 2010, 59: 511-520. PMID: 20093376, PMCID: PMC2855384, DOI: 10.1099/jmm.0.017715-0.
- Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infectionLan L, Murray TS, Kazmierczak BI, He C. Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection. Molecular Microbiology 2009, 75: 76-91. PMID: 19943895, PMCID: PMC2881571, DOI: 10.1111/j.1365-2958.2009.06955.x.
- Acute Pyelonephritis Caused by Aerococcus urinae in a 12-Year-Old BoyMurray TS, Muldrew KL, Finkelstein R, Hampton L, Edberg SC, Cappello M. Acute Pyelonephritis Caused by Aerococcus urinae in a 12-Year-Old Boy. The Pediatric Infectious Disease Journal 2008, 27: 760-762. PMID: 18574434, DOI: 10.1097/inf.0b013e318170af46.
- The Molecular Diagnosis of Parasitic DiseasesMurray TS, Cappello M. The Molecular Diagnosis of Parasitic Diseases. The Pediatric Infectious Disease Journal 2008, 27: 163-164. PMID: 18227715, DOI: 10.1097/inf.0b013e3181658af0.
- Pseudomonas aeruginosa Exhibits Sliding Motility in the Absence of Type IV Pili and Flagella▿ †Murray TS, Kazmierczak BI. Pseudomonas aeruginosa Exhibits Sliding Motility in the Absence of Type IV Pili and Flagella▿ †. Journal Of Bacteriology 2007, 190: 2700-2708. PMID: 18065549, PMCID: PMC2293233, DOI: 10.1128/jb.01620-07.
- Pediatric uses of fluoroquinolone antibiotics.Murray TS, Baltimore RS. Pediatric uses of fluoroquinolone antibiotics. Pediatric Annals 2007, 36: 336-42. PMID: 17727139, DOI: 10.3928/0090-4481-20070601-09.
- Pseudomonas aeruginosa chronic colonization in cystic fibrosis patientsMurray TS, Egan M, Kazmierczak BI. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Current Opinion In Pediatrics 2007, 19: 83-88. PMID: 17224667, DOI: 10.1097/mop.0b013e3280123a5d.
- FlhF Is Required for Swimming and Swarming in Pseudomonas aeruginosa†Murray TS, Kazmierczak BI. FlhF Is Required for Swimming and Swarming in Pseudomonas aeruginosa†. Journal Of Bacteriology 2006, 188: 6995-7004. PMID: 16980502, PMCID: PMC1595508, DOI: 10.1128/jb.00790-06.
- Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosaKazmierczak BI, Lebron MB, Murray TS. Analysis of FimX, a phosphodiesterase that governs twitching motility in Pseudomonas aeruginosa. Molecular Microbiology 2006, 60: 1026-1043. PMID: 16677312, PMCID: PMC3609419, DOI: 10.1111/j.1365-2958.2006.05156.x.
- Epidemiology and Management of Infectious Diseases in International AdopteesMurray TS, Groth ME, Weitzman C, Cappello M. Epidemiology and Management of Infectious Diseases in International Adoptees. Clinical Microbiology Reviews 2005, 18: 510-520. PMID: 16020687, PMCID: PMC1195971, DOI: 10.1128/cmr.18.3.510-520.2005.
- Characterization of ywhE, which encodes a putative high-molecular-weight class A penicillin-binding protein in Bacillus subtilisPedersen L, Ragkousi K, Cammett T, Melly E, Sekowska A, Schopick E, Murray T, Setlow P. Characterization of ywhE, which encodes a putative high-molecular-weight class A penicillin-binding protein in Bacillus subtilis. Gene 2000, 246: 187-196. PMID: 10767540, DOI: 10.1016/s0378-1119(00)00084-6.
- Analysis of outgrowth of Bacillus subtilis spores lacking penicillin-binding protein 2a.Murray T, Popham D, Pearson C, Hand A, Setlow P. Analysis of outgrowth of Bacillus subtilis spores lacking penicillin-binding protein 2a. Journal Of Bacteriology 1998, 180: 6493-502. PMID: 9851991, PMCID: PMC107750, DOI: 10.1128/jb.180.24.6493-6502.1998.
- Characterization of dacC, which encodes a new low-molecular-weight penicillin-binding protein in Bacillus subtilis.Pedersen L, Murray T, Popham D, Setlow P. Characterization of dacC, which encodes a new low-molecular-weight penicillin-binding protein in Bacillus subtilis. Journal Of Bacteriology 1998, 180: 4967-73. PMID: 9733705, PMCID: PMC107527, DOI: 10.1128/jb.180.18.4967-4973.1998.
- Bacillus subtilis cells lacking penicillin-binding protein 1 require increased levels of divalent cations for growth.Murray T, Popham D, Setlow P. Bacillus subtilis cells lacking penicillin-binding protein 1 require increased levels of divalent cations for growth. Journal Of Bacteriology 1998, 180: 4555-63. PMID: 9721295, PMCID: PMC107467, DOI: 10.1128/jb.180.17.4555-4563.1998.
- Identification and characterization of pbpA encoding Bacillus subtilis penicillin-binding protein 2A.Murray T, Popham D, Setlow P. Identification and characterization of pbpA encoding Bacillus subtilis penicillin-binding protein 2A. Journal Of Bacteriology 1997, 179: 3021-3029. PMID: 9139922, PMCID: PMC179068, DOI: 10.1128/jb.179.9.3021-3029.1997.
- Identification and characterization of pbpC, the gene encoding Bacillus subtilis penicillin-binding protein 3.Murray T, Popham D, Setlow P. Identification and characterization of pbpC, the gene encoding Bacillus subtilis penicillin-binding protein 3. Journal Of Bacteriology 1996, 178: 6001-6005. PMID: 8830698, PMCID: PMC178458, DOI: 10.1128/jb.178.20.6001-6005.1996.