Yale Medicine Magazine

Research at Yale School of Medicine is advancing our understanding of the aging brain and Alzheimer's disease, particularly through the development of treatments like lecanemab, which targets amyloid plaques and shows promise in slowing cognitive decline.

Experts from Yale discuss the importance of addressing age-related disabilities, promoting physical activity, combating ageism, and prioritizing individualized health care approaches to enhance the quality of life for older adults.

Yale School of Medicine is leading advancements in geriatrics and gerontology, focusing on the biological mechanisms of aging to extend healthy lifespans and improve quality of life for older adults. Through research initiatives and a patient-centered approach, Yale is pioneering treatments for age-related diseases and training future healthcare providers in holistic, personalized care for the aging population.

The emerging field of geroscience aims to understand the biological processes of aging to develop interventions that prevent multiple chronic diseases simultaneously, ultimately enhancing health and longevity.

At Yale School of Medicine, researchers are investigating various aspects of aging. Their work aims to uncover mechanisms that contribute to age-related diseases and identify potential therapeutic targets to enhance health in older adults.

Yale scientists discovered a monoclonal antibody capable of temporarily disabling the blood-brain barrier, potentially revolutionizing drug delivery for brain disorders, and have formed a startup, D2B3, to advance its development with support from Yale Ventures. This initiative enhances technology transfer by providing legal, financial, and mentoring assistance to faculty and students.

Lisa Lattanza, MD, chair of Orthopaedics & Rehabilitation at Yale School of Medicine, has made significant strides in surgical innovation, including the world's first fully in-house 3D surgical procedure and previously the first elbow transplant. Under her leadership, Yale is advancing personalized medicine through a dedicated 3D Collaborative for Medical Innovation, training programs for surgeons and engineers.

Cindy, a single mom from Texas, has been living with Long COVID for four years, experiencing symptoms that have significantly impacted her daily life and work as an aerospace engineer. The innovative PAX LC Trial, designed to make participation accessible by bringing the study directly to patients' homes across the U.S., aims to explore whether Paxlovid can alleviate Long COVID symptoms.

This past summer, Yale School of Medicine and Yale Medicine showcased their achievements on Broadway with a rotating electronic ad displayed on the Nasdaq building in Times Square, highlighting their leadership in various medical fields.

Dean Nancy J. Brown highlights promising areas of research, including the development of biomarkers for biological aging, studies on energy metabolism and inflammation, and the establishment of collaborative initiatives like the Yale Center for Research on Aging.