DownloadHi-Res Photo

Diane Krause, MD, PhD

Anthony N. Brady Professor of Laboratory Medicine and Professor of Pathology; Vice Chair for Research Affairs, Laboratory Medicine; Assoc. Director, Yale Stem Cell Center; Assoc. Director, Transfusion Medicine Service; Medical Director, Clinical Cell Processing Laboratory; Medical Director, Advanced Cell Therapy Laboratory

Research & Publications
Biography
News

Research Summary

The overall goals of my research are to characterize bone marrow (BM) derived stem/progenitor cells, and to define the mechanisms that regulate the self-renewal and differentiation of these cells with the goal of improving therapeutic approaches to hematological diseases including leukemia. We have 2 major foci. The first is the molecular mechanism(s) regulating gene expression during normal and malignant hematopoiesis. We are using hematopoietic stem cells and human embryonic stem cells to better understand Acute Megakaryoblastic Leukemia. In vitro and in vivo cell and molecular approaches will help us to better understand hematopoiesis and leukemogenesis. The second focus is the differentiation of pluripotent stem cells to produce function parathyroid epithelial cells in order to develop effective cellular therapy for patients with hypoparathyroidism. We welcome graduate students to join the lab.

Link to laboratory website: https://krauselab.net/

Specialized Terms: Bone Marrow Transplantation; Stem Cells; Cell and Molecular Hematology; Leukemia

Extensive Research Description

Hematopoiesis and leukemogenesis using bone marrow derived stem and progenitor cells Projects in the lab focus on molecular mechanisms that regulate early hematopoiesis and may be dysfunctional in leukemogenesis. Specifically, we are using primary cells as well as murine and human embryonic stem cells to study RBM15 and MKL1, two genes that are fused in the t(1;22) translocation associated with Acute Megakaryoblastic Leukemia AMKL). We are studying the roles of RBM15 and MKL1 in normal myelopoiesis and leukemogenesis. We have shown that RBM15 is downregulated as hematopoietic stem cells differentiate down the myeloid lineage such that megakaryoblasts express low levels of RBM15. When RBM15 is overexpressed, it prevents myeloid differentiation, and when RBM15 is inhibited or deleted, myeloid differentiation is enhanced, and there is a loss of hematopoietic stem and progenitor cell self-renewal. RBM15 can affect Notch signaling; RBM15 represses Notch induced Hes1 promoter activity. In addition, RBM15 is required for m6A RNA modification, and we are studying th role of this epitranscriptomic modification in normal hematopoiesis and leukemogenesis.

MKL1, identified at the C-terminus of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). The Krause laboratory has shown that MKL1 expression is upregulated during murine and human megakaryocytic differentiation, and that enforced overexpression of MKL1 enhances megakaryocytic differentiation. When the Human Erythroleukemia (HEL) cell line is induced to differentiate with TPA, overexpression of MKL1 results in an increased number of megakaryocytes with a concurrent increase in ploidy. MKL1 overexpression also promotes thrombopoietin-induced megakaryocytic differentiation of primary human CD34+ cells. The effect of MKL1 is abrogated when SRF is knocked down, suggesting that MKL1 acts through SRF. Consistent with these findings in human cells, knock out of MKL1 in mice leads to reduced platelet counts, and reduced ploidy in bone marrow megakaryocytes. Thus, MKL1 promotes physiological maturation of human and murine megakaryocytes.

Link to laboratory website: https://krauselab.net/

Coauthors

Research Interests

Cell Biology; Hematology; Leukemia; Pathology; Stem Cells; Gene Expression; Bone Marrow Transplantation

Selected Publications

Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosisÖz H, Cheng E, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang P, Huang P, Esquibies S, Britto C, Schupp J, Murray T, Halene S, Krause D, Egan M, Bruscia E. Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis Cell Reports 2022, 41: 111797. PMID: 36516754, PMCID: PMC9833830, DOI: 10.1016/j.celrep.2022.111797.
Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiationScanlon VM, Thompson EN, Lawton BR, Kochugaeva M, Ta K, Mayday MY, Xavier-Ferrucio J, Kang E, Eskow NM, Lu YC, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Larsuel ST, Reed FE, Peña-Carmona G, Ubbelohde A, Lee JP, Boobalan S, Oppong Y, Anderson R, Maynard C, Sahirul K, Lajeune C, Ivathraya V, Addy T, Sanchez P, Holbrook C, Van Ho AT, Duncan JS, Blau HM, Levchenko A, Krause DS. Multiparameter analysis of timelapse imaging reveals kinetics of megakaryocytic erythroid progenitor clonal expansion and differentiation Scientific Reports 2022, 12: 16218. PMID: 36171423, PMCID: PMC9519589, DOI: 10.1038/s41598-022-19013-x.
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization.Reed FE, Eskow NM, Min E, Carlino M, Mancuso R, Kwon N, Smith EC, Larsuel ST, Wang L, Scanlon V, Krause DS. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization. Haematologica 2022 PMID: 36005559.
Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidizationReed F, Eskow N, Min E, Carlino M, Mancuso R, Kwon N, Smith E, Larsuel S, Wang L, Scanlon V, Krause D. Structure-function analysis of the role of megakaryoblastic leukemia 1 in megakaryocyte polyploidization Haematologica 2022, 107: 2972-2976. PMID: 36453520, PMCID: PMC9713552, DOI: 10.3324/haematol.2021.280499.
Gene therapy applications to transfusion medicineTabibi S, Gehrie E, Bruscia E, Krause D. Gene therapy applications to transfusion medicine 2022, 642-647. DOI: 10.1002/9781119719809.ch56.
Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosisDi Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis Experimental & Molecular Medicine 2022, 54: 639-652. PMID: 35581352, PMCID: PMC9166813, DOI: 10.1038/s12276-022-00770-8.
3118 – RUNX1 AS A REGULATOR OF MEP FATE IN RESPONSE TO CELL CYCLE DYNAMICSKwon N, Lu Y, Wang L, Zhang P, Thompson E, Friedman A, Krause D. 3118 – RUNX1 AS A REGULATOR OF MEP FATE IN RESPONSE TO CELL CYCLE DYNAMICS Experimental Hematology 2022, 111: s103-s104. DOI: 10.1016/j.exphem.2022.07.174.
3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENTScanlon V, Thompson E, Lawton B, Kochugaeva M, Kang E, Eskow N, Sanchez P, Bobbalan S, Cenci M, Pena-Carmona G, Laumas A, Anderson R, Reed F, Blau H, Levchenko A, Krause D. 3181 – ERYTHROPOIETIN SUPPORTS SURVIVAL AND SELF-RENEWAL OF PRIMARY HUMAN MEGAKARYOCYTIC-ERYTHROID PROGENITORS, BUT DOES NOT INSTRUCT LINEAGE COMMITMENT Experimental Hematology 2022, 111: s135. DOI: 10.1016/j.exphem.2022.07.237.
558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosisPietro C, Öz H, Zhang P, Cheng E, Martis V, Bonfield T, Kelley T, Jubin R, Abuchowski A, Krause D, Egan M, Murray T, Bruscia E. 558: Carbon monoxide–based therapy primes macrophages to express HO-1 and to resolve lung hyper-inflammation in cystic fibrosis Journal Of Cystic Fibrosis 2021, 20: s263-s264. DOI: 10.1016/s1569-1993(21)01981-0.
1016 – INSIGHTS INTO ERYTHROPOIESIS AND MEGAKARYOPOIESIS AT THE SINGLE CELL LEVELKrause D, Lu Y, Scanlon V. 1016 – INSIGHTS INTO ERYTHROPOIESIS AND MEGAKARYOPOIESIS AT THE SINGLE CELL LEVEL Experimental Hematology 2021, 100: s22-s23. DOI: 10.1016/j.exphem.2021.12.012.
Methylation of dual-specificity phosphatase 4 controls cell differentiation.Su H, Jiang M, Senevirathne C, Aluri S, Zhang T, Guo H, Xavier-Ferrucio J, Jin S, Tran NT, Liu SM, Sun CW, Zhu Y, Zhao Q, Chen Y, Cable L, Shen Y, Liu J, Qu CK, Han X, Klug CA, Bhatia R, Chen Y, Nimer SD, Zheng YG, Iancu-Rubin C, Jin J, Deng H, Krause DS, Xiang J, Verma A, Luo M, Zhao X. Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell Reports 2021, 36: 109421. PMID: 34320342, PMCID: PMC9110119, DOI: 10.1016/j.celrep.2021.109421.
Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung InjuryCiechanowicz AK, Sielatycka K, Cymer M, Skoda M, Suszyńska M, Bujko K, Ratajczak MZ, Krause DS, Kucia M. Bone Marrow-Derived VSELs Engraft as Lung Epithelial Progenitor Cells after Bleomycin-Induced Lung Injury Cells 2021, 10: 1570. PMID: 34206516, PMCID: PMC8303224, DOI: 10.3390/cells10071570.
Combined liver–cytokine humanization comes to the rescue of circulating human red blood cellsSong Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells Science 2021, 371: 1019-1025. PMID: 33674488, PMCID: PMC8292008, DOI: 10.1126/science.abe2485.
Single cell epigenetic visualization assayKint S, Van Criekinge W, Vandekerckhove L, De Vos WH, Bomsztyk K, Krause DS, Denisenko O. Single cell epigenetic visualization assay Nucleic Acids Research 2021, 49: gkab009-. PMID: 33511400, PMCID: PMC8096246, DOI: 10.1093/nar/gkab009.
MRTFA: a critical protein in normal and malignant hematopoiesis and beyondReed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS. MRTFA: a critical protein in normal and malignant hematopoiesis and beyond Journal Of Biological Chemistry 2021, 296: 100543. PMID: 33722605, PMCID: PMC8079280, DOI: 10.1016/j.jbc.2021.100543.
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammationGu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.
Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants.Kwon N, Thompson EN, Mayday MY, Scanlon V, Lu YC, Krause DS. Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants. Current Opinion In Hematology 2020, 28: 28-35. PMID: 33186151, PMCID: PMC7737300, DOI: 10.1097/moh.0000000000000625.
Cell Cycle Regulates Phosphorylation of RUNX1 to Modulate Megakaryocyte-Erythroid Progenitor Fate SpecificationLu Y, Scanlon V, Xavier-Ferrucio J, Wang L, Friedman A, Cantor A, Krause D. Cell Cycle Regulates Phosphorylation of RUNX1 to Modulate Megakaryocyte-Erythroid Progenitor Fate Specification Blood 2020, 136: 15-15. DOI: 10.1182/blood-2020-141156.
Reconstruction of Sickle Cell Disease with Circulating Sickling Red Blood Cells in Novel Humanized Cytokines and Liver Mistrg MiceSong Y, Gbyli R, Shan L, Liu W, Gao Y, Patel A, Fu X, Wang X, Xu M, Qin A, Bruscia E, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Gonzales D, Krause D, Alderman J, Flavell R, Halene S. Reconstruction of Sickle Cell Disease with Circulating Sickling Red Blood Cells in Novel Humanized Cytokines and Liver Mistrg Mice Blood 2020, 136: 29-30. DOI: 10.1182/blood-2020-141603.
Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells.Lawton BR, Martineau C, Sosa JA, Roman S, Gibson CE, Levine MA, Krause DS. Differentiation of PTH-Expressing Cells From Human Pluripotent Stem Cells. Endocrinology 2020, 161 PMID: 32810225, PMCID: PMC7505176, DOI: 10.1210/endocr/bqaa141.
Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict PotentialScanlon V, Kochugaeva M, Xavier-Ferrucio J, Lu Y, Kwon N, Laumas A, Cenci M, Lawrence K, Barden K, Holbrook C, Tri Van Ho A, Blau H, Levchenko A, Krause D. Developing Single Cell Live Imaging Strategies to Determine MEP Fate and Predict Potential Blood 2019, 134: 1190-1190. DOI: 10.1182/blood-2019-131204.
A versatile flow-based assay for immunocyte-mediated cytotoxicityRabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancyTal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.
Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS. Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. Blood 2019, 134: 1547-1557. PMID: 31439541, PMCID: PMC6839952, DOI: 10.1182/blood.2019002039.
Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common SubunitHe L, Cohen EB, Edwards APB, Xavier-Ferrucio J, Bugge K, Federman RS, Absher D, Myers RM, Kragelund BB, Krause DS, DiMaio D. Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit IScience 2019, 17: 167-181. PMID: 31279934, PMCID: PMC6614117, DOI: 10.1016/j.isci.2019.06.027.
IFN-γ binds TPO to inhibit hematopoiesisKrause DS. IFN-γ binds TPO to inhibit hematopoiesis Blood 2019, 133: 2004-2005. PMID: 31072961, DOI: 10.1182/blood-2019-03-900977.
Macrophages in Chronic CF Lung Inflammation, Resolution and RemodelingOz H, Di Pietro C, Cheng E, Zhang P, Nguyen R, Barone C, Krause D, Egan M, Bruscia E. Macrophages in Chronic CF Lung Inflammation, Resolution and Remodeling 2019, a6186-a6186. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6186.
Targeting the HO-1/CO Pathway with Sanguinate: Toward Development of a Novel Anti-inflammatory Therapy for Cystic Fibrosis (CF) Lung DiseaseDi Pietro C, Oz H, Martis V, Zhang P, Jubin R, Abuchowski A, Krause D, Egan M, Murray T, Bruscia E. Targeting the HO-1/CO Pathway with Sanguinate: Toward Development of a Novel Anti-inflammatory Therapy for Cystic Fibrosis (CF) Lung Disease 2019, a6187-a6187. DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6187.
MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activationHu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation Nature Communications 2019, 10: 1695. PMID: 30979898, PMCID: PMC6461646, DOI: 10.1038/s41467-019-09636-6.
Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot StabilityScanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability Thrombosis And Haemostasis 2019, 119: 744-757. PMID: 30861547, PMCID: PMC6599679, DOI: 10.1055/s-0039-1679908.
Promoters to Study Vascular Smooth MuscleChakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA. Promoters to Study Vascular Smooth Muscle Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 603-612. PMID: 30727757, PMCID: PMC6527360, DOI: 10.1161/atvbaha.119.312449.
Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulationWang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucio J, Lu YC, Zhang M, Roden C, Cheng J, Krause DS, Ding Y, Fan R, Lu J. Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation Nature Communications 2019, 10: 95. PMID: 30626865, PMCID: PMC6327095, DOI: 10.1038/s41467-018-07981-6.
The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate SpecificationLu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification Cell Reports 2018, 25: 3229. PMID: 30540953, PMCID: PMC6357951, DOI: 10.1016/j.celrep.2018.11.075.
Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and MiceXavier-Ferrucio J, Li X, Scanlon V, Zhang P, Ayala-Lopez N, Tebaldi T, Halene S, Finberg K, Krause D. Low Iron Promotes Megakaryocytic Commitment of Megakaryocytic-Erythroid Progenitors in Human and Mice Blood 2018, 132: 2-2. DOI: 10.1182/blood-2018-99-115124.
Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals Role of Cell Cycle in Fate SpecificationLu Y, Krause D, Xavier-Ferrucio J, Wang L, Salomonis N, Chetal K, Aronow B, Sanada C, Venkatasubramanian M. Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals Role of Cell Cycle in Fate Specification Blood 2018, 132: 3828-3828. DOI: 10.1182/blood-2018-99-119105.
MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory AxisRahman N, Schulz V, Wang L, Gallagher P, Denisenko O, Gualdrini F, Cyril E, Krause D. MRTFA Augments Megakaryocyte Maturation By Enhancing the SRF Regulatory Axis Blood 2018, 132: 640-640. DOI: 10.1182/blood-2018-99-118954.
The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate SpecificationLu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification Cell Reports 2018, 25: 2083-2093.e4. PMID: 30463007, PMCID: PMC6336197, DOI: 10.1016/j.celrep.2018.10.084.
MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axisRahman NT, Schulz VP, Wang L, Gallagher PG, Denisenko O, Gualdrini F, Esnault C, Krause DS. MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis Blood Advances 2018, 2: 2691-2703. PMID: 30337297, PMCID: PMC6199649, DOI: 10.1182/bloodadvances.2018019448.
Concise Review: Bipotent Megakaryocytic‐Erythroid Progenitors: Concepts and ControversiesXavier‐Ferrucio J, Krause DS. Concise Review: Bipotent Megakaryocytic‐Erythroid Progenitors: Concepts and Controversies Stem Cells 2018, 36: 1138-1145. PMID: 29658164, PMCID: PMC6105498, DOI: 10.1002/stem.2834.
Role of RNA Binding Protein RBM15 in m6A RNA Methylation During Megakaryocytic DifferentiationAyala‐Lopez N, Ross R, Halene S, Limbach P, Krause D. Role of RNA Binding Protein RBM15 in m6A RNA Methylation During Megakaryocytic Differentiation The FASEB Journal 2018, 32: 790.9-790.9. DOI: 10.1096/fasebj.2018.32.1_supplement.790.9.
Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repairJin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang P, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair American Journal Of Physiology - Lung Cellular And Molecular Physiology 2018, 314: l882-l892. PMID: 29345196, PMCID: PMC6008135, DOI: 10.1152/ajplung.00418.2017.
Hematopoietic defects in response to reduced Arhgap21Xavier-Ferrucio J, Ricon L, Vieira K, Longhini AL, Lazarini M, Bigarella CL, Franchi G, Krause DS, Saad STO. Hematopoietic defects in response to reduced Arhgap21 Stem Cell Research 2017, 26: 17-27. PMID: 29212046, PMCID: PMC6084430, DOI: 10.1016/j.scr.2017.11.014.
Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophagesDi Pietro C, Zhang PX, O’Rourke T, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages Scientific Reports 2017, 7: 10882. PMID: 28883468, PMCID: PMC5589856, DOI: 10.1038/s41598-017-11012-7.
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volumeZou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume PLOS ONE 2017, 12: e0178095. PMID: 28542600, PMCID: PMC5441597, DOI: 10.1371/journal.pone.0178095.
Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomesde Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA. Pediatric non–Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes Nature Genetics 2017, 49: 451-456. PMID: 28112737, PMCID: PMC5687824, DOI: 10.1038/ng.3772.
In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle deliveryBahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM. In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery Nature Communications 2016, 7: 13304. PMID: 27782131, PMCID: PMC5095181, DOI: 10.1038/ncomms13304.
ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarctionBartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y. ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction JCI Insight 2016, 1: e80920. PMID: 27525311, PMCID: PMC4982472, DOI: 10.1172/jci.insight.80920.
Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction.Sanada C, Xavier-Ferrucio J, Lu YC, Min E, Zhang PX, Zou S, Kang E, Zhang M, Zerafati G, Gallagher PG, Krause DS. Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood 2016, 128: 923-33. PMID: 27268089, PMCID: PMC4990855, DOI: 10.1182/blood-2016-01-693705.
Gene therapy applications to transfusion medicineGehrie E, Bersenev A, Bruscia E, Krause D, Schulz W. Gene therapy applications to transfusion medicine 2016, 452-455. DOI: 10.1002/9781119013020.ch38.
An oxidase road to platelet adhesionKrause DS. An oxidase road to platelet adhesion Blood 2016, 127: 1386-1386. PMID: 26989190, DOI: 10.1182/blood-2016-01-694935.
The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated InflammationChae WJ, Ehrlich AK, Chan PY, Teixeira AM, Henegariu O, Hao L, Shin JH, Park JH, Tang WH, Kim ST, Maher SE, Goldsmith-Pestana K, Shan P, Hwa J, Lee PJ, Krause DS, Rothlin CV, McMahon-Pratt D, Bothwell AL. The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation Immunity 2016, 44: 246-258. PMID: 26872695, PMCID: PMC4758884, DOI: 10.1016/j.immuni.2016.01.008.
Increased susceptibility of Cftr−/− mice to LPS-induced lung remodelingBruscia E, Zhang P, Barone C, Scholte BJ, Homer R, Krause D, Egan ME. Increased susceptibility of Cftr−/− mice to LPS-induced lung remodeling American Journal Of Physiology - Lung Cellular And Molecular Physiology 2016, 310: l711-l719. PMID: 26851259, PMCID: PMC4836110, DOI: 10.1152/ajplung.00284.2015.
Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activationZou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferrucio J, Zhang PX, Hwa J, Min W, Krause DS. Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation Thrombosis And Haemostasis 2016, 116: 506-516. PMID: 27345948, PMCID: PMC5845781, DOI: 10.1160/th15-11-0848.
A Human Bone Marrow-Derived Stromal Cell Population with Hemogenic PotentialMokhtari S, Colletti E, Sanada C, Lamar Z, Simmons P, Atala A, Krause D, Zanjani E, Porada C, Almeida-Porada G. A Human Bone Marrow-Derived Stromal Cell Population with Hemogenic Potential Blood 2015, 126: 1201-1201. DOI: 10.1182/blood.v126.23.1201.1201.
Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genesde Rooij J, Branstetter C, Ma J, Li Y, Cheng J, Koss C, Easton J, Verboon L, Mulder H, Rusch M, Lim J, Reinhardt K, Yeoh A, Shih L, Liang D, Halene S, Krause D, Zhang J, Downing J, Locatelli F, Reinhardt D, van den Heuvel-Eibrink M, Forenerod M, Zwaan C, Gruber T. Next Generation Sequencing Identifies a Novel Subset of Non-Down Syndrome Acute Megakaryoblastic Leukemia Characterized By Chimeric Transcripts Involving HOX Cluster Genes Blood 2015, 126: 171-171. DOI: 10.1182/blood.v126.23.171.171.
Megakaryocytic Fate Specification and MaturationKrause D. Megakaryocytic Fate Specification and Maturation Blood 2015, 126: sci-2-sci-2. DOI: 10.1182/blood.v126.23.sci-2.sci-2.
Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesisSui Z, Nowak RB, Sanada C, Halene S, Krause DS, Fowler VM. Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis Blood 2015, 126: 520-530. PMID: 25964668, PMCID: PMC4513252, DOI: 10.1182/blood-2014-09-601484.
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammationZhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.
Stem cell maintenance: aMPLe splicing choicesHalene S, Krause DS. Stem cell maintenance: aMPLe splicing choices Blood 2015, 125: 891-892. PMID: 25655452, DOI: 10.1182/blood-2014-12-616326.
Single Cell Transcriptome Profiling of Highly Purified Human Megakaryocyte-Erythroid Progenitors (MEP) Reveals New Insights into the MEP Fate DecisionSanada C, Min E, Zou S, Jin H, Zhang P, Aronow B, Krause D. Single Cell Transcriptome Profiling of Highly Purified Human Megakaryocyte-Erythroid Progenitors (MEP) Reveals New Insights into the MEP Fate Decision Blood 2014, 124: 2903-2903. DOI: 10.1182/blood.v124.21.2903.2903.
ARHGEF12 Is Essential for Human Megakaryocyte Differentiation and Plays Critical Roles in Platelet FunctionZou S, Teixeira A, Sanada C, Zhang P, Krause D. ARHGEF12 Is Essential for Human Megakaryocyte Differentiation and Plays Critical Roles in Platelet Function Blood 2014, 124: 341-341. DOI: 10.1182/blood.v124.21.341.341.
Codanin-1 Binds to Key Erythroid Genes and Its Knockdown Coupled with Ectopic Mutant Expression Recapitulates the Congenital Dyserythropoietic Anemia Type I (CDA I) PhenotypeBosques L, Tang C, Krause D, Weissman S, Gallagher P, Weiss M, Tamary H, Kupfer G. Codanin-1 Binds to Key Erythroid Genes and Its Knockdown Coupled with Ectopic Mutant Expression Recapitulates the Congenital Dyserythropoietic Anemia Type I (CDA I) Phenotype Blood 2014, 124: 360-360. DOI: 10.1182/blood.v124.21.360.360.
Epithelial (E)-Cadherin Is a Novel Regulator of Platelet FunctionKrause D, Halene S, Booth C, Jin H, Zou S, Teixeira A, Zhang P. Epithelial (E)-Cadherin Is a Novel Regulator of Platelet Function Blood 2014, 124: 95-95. DOI: 10.1182/blood.v124.21.95.95.
Tmod3 participates in platelet formation and sizing in mouse fetal liver (278.9)Sui Z, Robeta N, Sanada C, Halene S, Krause D, Fowler V. Tmod3 participates in platelet formation and sizing in mouse fetal liver (278.9) The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.278.9.
Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T CellsBleakley M, Heimfeld S, Jones LA, Turtle C, Krause D, Riddell SR, Shlomchik W. Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells Transplantation And Cellular Therapy 2014, 20: 705-716. PMID: 24525279, PMCID: PMC3985542, DOI: 10.1016/j.bbmt.2014.01.032.
Nonstochastic Reprogramming from a Privileged Somatic Cell StateGuo S, Zi X, Schulz VP, Cheng J, Zhong M, Koochaki SH, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J. Nonstochastic Reprogramming from a Privileged Somatic Cell State Cell 2014, 156: 649-662. PMID: 24486105, PMCID: PMC4318260, DOI: 10.1016/j.cell.2014.01.020.
Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the LungKassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Very Small Embryonic‐Like Stem Cells from the Murine Bone Marrow Differentiate into Epithelial Cells of the Lung Stem Cells 2013, 31: 2759-2766. PMID: 23681901, PMCID: PMC4536826, DOI: 10.1002/stem.1413.
Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for LeukemiaKrause DS, Crispino JD. Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia Clinical Cancer Research 2013, 19: 6084-6088. PMID: 23963861, PMCID: PMC3836832, DOI: 10.1158/1078-0432.ccr-12-2604.
Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemiaKim Y, Schulz VP, Satake N, Gruber TA, Teixeira AM, Halene S, Gallagher PG, Krause DS. Whole-exome sequencing identifies a novel somatic mutation in MMP8 associated with a t(1;22)-acute megakaryoblastic leukemia Leukemia 2013, 28: 945-948. PMID: 24157583, PMCID: PMC3981934, DOI: 10.1038/leu.2013.314.
Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem CellsLawton BR, Sosa JA, Roman S, Krause DS. Effect of a Matrigel Sandwich on Endodermal Differentiation of Human Embryonic Stem Cells Stem Cell Reviews And Reports 2013, 9: 578-585. PMID: 23719997, DOI: 10.1007/s12015-013-9447-2.
Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance RegulatorZhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. Reduced Caveolin-1 Promotes Hyperinflammation due to Abnormal Heme Oxygenase-1 Localization in Lipopolysaccharide-Challenged Macrophages with Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator The Journal Of Immunology 2013, 190: 5196-5206. PMID: 23606537, PMCID: PMC3711148, DOI: 10.4049/jimmunol.1201607.
Dynamic Migration and Cell‐Cell Interactions of Early Reprogramming Revealed by High‐Resolution Time‐Lapse ImagingMegyola CM, Gao Y, Teixeira AM, Cheng J, Heydari K, Cheng E, Nottoli T, Krause DS, Lu J, Guo S. Dynamic Migration and Cell‐Cell Interactions of Early Reprogramming Revealed by High‐Resolution Time‐Lapse Imaging Stem Cells 2013, 31: 895-905. PMID: 23335078, PMCID: PMC4309553, DOI: 10.1002/stem.1323.
Very small embryonic‐like cells: Biology and function of these potential endogenous pluripotent stem cells in adult tissuesKassmer SH, Krause DS. Very small embryonic‐like cells: Biology and function of these potential endogenous pluripotent stem cells in adult tissues Molecular Reproduction And Development 2013, 80: 677-690. PMID: 23440892, PMCID: PMC3740022, DOI: 10.1002/mrd.22168.
Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activationSmith EC, Teixeira AM, Chen RC, Wang L, Gao Y, Hahn KL, Krause DS. Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation Blood 2012, 121: 1094-1101. PMID: 23243284, PMCID: PMC3575755, DOI: 10.1182/blood-2012-05-429993.
Optimization of a Clonal Assay for Bipotent Megakaryocyte-Erythroid Progenitors (MEP), and Their Enrichment From Mobilized Peripheral Blood.Sanada C, Zhang P, Zerafati G, Krause D. Optimization of a Clonal Assay for Bipotent Megakaryocyte-Erythroid Progenitors (MEP), and Their Enrichment From Mobilized Peripheral Blood. Blood 2012, 120: 2310-2310. DOI: 10.1182/blood.v120.21.2310.2310.
Induction of Megakaryocyte Differentiation Drives Nuclear Accumulation and Transcriptional Function of MKL1 Via Actin Polymerization and RhoA ActivationSmith E, Teixeira A, Chen R, Wang L, Gao Y, Hahn K, Krause D. Induction of Megakaryocyte Differentiation Drives Nuclear Accumulation and Transcriptional Function of MKL1 Via Actin Polymerization and RhoA Activation Blood 2012, 120: 3440-3440. DOI: 10.1182/blood.v120.21.3440.3440.
Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasiaD'Souza AD, Parish IA, Krause DS, Kaech SM, Shadel GS. Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia Molecular Therapy 2012, 21: 42-48. PMID: 23011031, PMCID: PMC3538311, DOI: 10.1038/mt.2012.203.
Complex oncogene dependence in microRNA-125a–induced myeloproliferative neoplasmsGuo S, Bai H, Megyola CM, Halene S, Krause DS, Scadden DT, Lu J. Complex oncogene dependence in microRNA-125a–induced myeloproliferative neoplasms Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16636-16641. PMID: 23012470, PMCID: PMC3478612, DOI: 10.1073/pnas.1213196109.
MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formationSmith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation Blood 2012, 120: 2317-2329. PMID: 22806889, PMCID: PMC3447785, DOI: 10.1182/blood-2012-04-420828.
Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high‐dose granulocyte colony‐stimulating factorCooper DL, Proytcheva M, Medoff E, Seropian SE, Snyder EL, Krause DS, Wu Y. Successful collection and engraftment of autologous peripheral blood progenitor cells in poorly mobilized patients receiving high‐dose granulocyte colony‐stimulating factor Journal Of Clinical Apheresis 2012, 27: 235-241. PMID: 22566214, DOI: 10.1002/jca.21232.
Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in MegakaryocytesGao Y, Smith E, Ker E, Campbell P, Cheng EC, Zou S, Lin S, Wang L, Halene S, Krause DS. Role of RhoA-Specific Guanine Exchange Factors in Regulation of Endomitosis in Megakaryocytes Developmental Cell 2012, 22: 573-584. PMID: 22387001, PMCID: PMC3306542, DOI: 10.1016/j.devcel.2011.12.019.
Nonhematopoietic Cells are the Primary Source of Bone Marrow‐Derived Lung Epithelial CellsKassmer SH, Bruscia EM, Zhang P, Krause DS. Nonhematopoietic Cells are the Primary Source of Bone Marrow‐Derived Lung Epithelial Cells Stem Cells 2012, 30: 491-499. PMID: 22162244, PMCID: PMC3725285, DOI: 10.1002/stem.1003.
ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and PlateletsTruman LA, Bentley KL, Smith EC, Massaro SA, Gonzalez DG, Haberman AM, Hill M, Jones D, Min W, Krause DS, Ruddle NH. ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets American Journal Of Pathology 2012, 180: 1715-1725. PMID: 22310467, PMCID: PMC3349900, DOI: 10.1016/j.ajpath.2011.12.026.
Increased Tubular Proliferation as an Adaptive Response to Glomerular AlbuminuriaGuo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.
MKL2 Functions in the Absence of MKL1 to Promote Megakaryocyte MaturationSmith E, Thon J, Massaro S, Italiano J, Krause D. MKL2 Functions in the Absence of MKL1 to Promote Megakaryocyte Maturation Blood 2011, 118: 2336-2336. DOI: 10.1182/blood.v118.21.2336.2336.
Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinational and temporal adjustment of soluble factorsQian L, Krause DS, Saltzman WM. Enhanced growth and hepatic differentiation of fetal liver epithelial cells through combinational and temporal adjustment of soluble factors Biotechnology Journal 2011, 7: 440-448. PMID: 21922669, PMCID: PMC3532892, DOI: 10.1002/biot.201100184.
Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide ConjugateRogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM. Targeted Gene Modification of Hematopoietic Progenitor Cells in Mice Following Systemic Administration of a PNA-peptide Conjugate Molecular Therapy 2011, 20: 109-118. PMID: 21829173, PMCID: PMC3255600, DOI: 10.1038/mt.2011.163.
Tissue‐engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vesselHibino N, Villalona G, Pietris N, Duncan DR, Schoffner A, Roh JD, Yi T, Dobrucki LW, Mejias D, Sawh‐Martinez R, Harrington JK, Sinusas A, Krause DS, Kyriakides T, Saltzman WM, Pober JS, Shin'oka T, Breuer CK. Tissue‐engineered vascular grafts form neovessels that arise from regeneration of the adjacent blood vessel The FASEB Journal 2011, 25: 2731-2739. PMID: 21566209, PMCID: PMC3136337, DOI: 10.1096/fj.11-182246.
Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic FibrosisBruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis The Journal Of Immunology 2011, 186: 6990-6998. PMID: 21593379, PMCID: PMC3111054, DOI: 10.4049/jimmunol.1100396.
Bi‐allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemiaMassaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P. Bi‐allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia Pediatric Blood & Cancer 2011, 57: 516-519. PMID: 21538823, PMCID: PMC4517576, DOI: 10.1002/pbc.23156.
Activation of autophagy in mesenchymal stem cells provides tumor stromal supportSanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS, Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support Carcinogenesis 2011, 32: 964-972. PMID: 21317300, PMCID: PMC3128555, DOI: 10.1093/carcin/bgr029.
Modeling Megakaryopoiesis and Leukemogenesis Using Human and Murine Embryonic Stem CellsMassaro S, Smith E, Iacovino M, Kyba M, Krause D. Modeling Megakaryopoiesis and Leukemogenesis Using Human and Murine Embryonic Stem Cells Blood 2010, 116: 2502-2502. DOI: 10.1182/blood.v116.21.2502.2502.
Bone Marrow Derived Lung Epithelial Cells Are Derived Predominantly From Nonhematopoietic Cells.Kassmer S, Bruscia E, Zhang P, Krause D. Bone Marrow Derived Lung Epithelial Cells Are Derived Predominantly From Nonhematopoietic Cells. Blood 2010, 116: 2615-2615. DOI: 10.1182/blood.v116.21.2615.2615.
Intermediate Steps In Erythroid, Megakaryocytic and Myeloid Lineage SpecificationLian Z, Mahajan M, Schulz V, Gulcicek E, Krause D, Weissman S. Intermediate Steps In Erythroid, Megakaryocytic and Myeloid Lineage Specification Blood 2010, 116: 4778-4778. DOI: 10.1182/blood.v116.21.4778.4778.
Discovery that polyploid cells can undergo mitosis.Gao Y, Krause D. Discovery that polyploid cells can undergo mitosis. Cell Cycle (Georgetown, Tex.) 2010, 9: 2500. PMID: 20647753.
Serum response factor is an essential transcription factor in megakaryocytic maturationHalene S, Gao Y, Hahn K, Massaro S, Italiano JE, Schulz V, Lin S, Kupfer GM, Krause DS. Serum response factor is an essential transcription factor in megakaryocytic maturation Blood 2010, 116: 1942-1950. PMID: 20525922, PMCID: PMC3173990, DOI: 10.1182/blood-2010-01-261743.
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesisYu L, Ji W, Zhang H, Renda M, He Y, Lin S, Cheng E, Chen H, Krause D, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis Journal Of Cell Biology 2010, 189: i12-i12. DOI: 10.1083/jcb1894oia12.
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesisYu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis Journal Of Experimental Medicine 2010, 207: 1183-1195. PMID: 20457756, PMCID: PMC2882842, DOI: 10.1084/jem.20092215.
Detection of bone marrow–derived lung epithelial cellsKassmer SH, Krause DS. Detection of bone marrow–derived lung epithelial cells Experimental Hematology 2010, 38: 564-573. PMID: 20447442, PMCID: PMC2909593, DOI: 10.1016/j.exphem.2010.04.011.
SENP1‐mediated GATA1 deSUMOylation is critical for definitive erythropoiesisYu L, Krause D, Min W. SENP1‐mediated GATA1 deSUMOylation is critical for definitive erythropoiesis The FASEB Journal 2010, 24: 115.2-115.2. DOI: 10.1096/fasebj.24.1_supplement.115.2.
C/EBPε directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via HlxHalene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause D, Berliner N. C/EBPε directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx Experimental Hematology 2009, 38: 90-103.e4. PMID: 19925846, PMCID: PMC2827304, DOI: 10.1016/j.exphem.2009.11.004.
Serum Response Factor Is An Essential Transcription Factor in Megakaryocytic Maturation.Halene S, Gao Y, Hahn K, Smith E, Lin S, Perkins A, Krause D. Serum Response Factor Is An Essential Transcription Factor in Megakaryocytic Maturation. Blood 2009, 114: 3652-3652. DOI: 10.1182/blood.v114.22.3652.3652.
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 InteractionZhi G, Wilson JB, Chen X, Krause DS, Xiao Y, Jones NJ, Kupfer GM. Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction Cancer Research 2009, 69: 8775-8783. PMID: 19861535, PMCID: PMC5912675, DOI: 10.1158/0008-5472.can-09-2312.
Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cellsMohamadnejad M, Sohail MA, Watanabe A, Krause DS, Swenson ES, Mehal WZ. Adenosine inhibits chemotaxis and induces hepatocyte‐specific genes in bone marrow mesenchymal stem cells Hepatology 2009, 51: 963-973. PMID: 20044808, PMCID: PMC2840188, DOI: 10.1002/hep.23389.
Understanding the mysteries of iPS cells.Cohen JB, Krause DS. Understanding the mysteries of iPS cells. The Yale Journal Of Biology And Medicine 2009, 82: 105-7. PMID: 19774121, PMCID: PMC2744933.
Regeneration and RepairFriedman RS, Krause DS. Regeneration and Repair Annals Of The New York Academy Of Sciences 2009, 1172: 88-94. PMID: 19735242, DOI: 10.1111/j.1749-6632.2009.04411.x.
Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in cultureMahajan MC, Karmakar S, Newburger PE, Krause DS, Weissman SM. Dynamics of α-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34+ cells in culture Experimental Hematology 2009, 37: 1143-1156.e3. PMID: 19607874, PMCID: PMC2997688, DOI: 10.1016/j.exphem.2009.07.001.
Role for MKL1 in megakaryocytic maturationCheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. Role for MKL1 in megakaryocytic maturation Blood 2009, 113: 2826-2834. PMID: 19136660, PMCID: PMC2661865, DOI: 10.1182/blood-2008-09-180596.
Gene Therapy in Transfusion MedicineBruscia E, Krause D. Gene Therapy in Transfusion Medicine 2009, 936-949. DOI: 10.1002/9781444303513.ch60.
Chimeric mice reveal clonal development of pancreatic acini, but not isletsSwenson ES, Xanthopoulos J, Nottoli T, McGrath J, Theise ND, Krause DS. Chimeric mice reveal clonal development of pancreatic acini, but not islets Biochemical And Biophysical Research Communications 2008, 379: 526-531. PMID: 19116141, PMCID: PMC2657659, DOI: 10.1016/j.bbrc.2008.12.104.
Influence of Culture Medium on Smooth Muscle Cell Differentiation from Human Bone Marrow–Derived Mesenchymal Stem CellsGong Z, Calkins G, Cheng EC, Krause D, Niklason LE. Influence of Culture Medium on Smooth Muscle Cell Differentiation from Human Bone Marrow–Derived Mesenchymal Stem Cells Tissue Engineering Part A 2008, 15: 319-330. PMID: 19115826, PMCID: PMC2716410, DOI: 10.1089/ten.tea.2008.0161.
OTT-MKL1 and MKL1 Inhibit Wnt Signaling.Halene S, Cheng E, Schulz V, Tuck D, Krause D. OTT-MKL1 and MKL1 Inhibit Wnt Signaling. Blood 2008, 112: 2250-2250. DOI: 10.1182/blood.v112.11.2250.2250.
Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acidsChin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R, Glazer PM. Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 13514-13519. PMID: 18757759, PMCID: PMC2533221, DOI: 10.1073/pnas.0711793105.
Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/− MiceBruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Macrophages Directly Contribute to the Exaggerated Inflammatory Response in Cystic Fibrosis Transmembrane Conductance Regulator−/− Mice American Journal Of Respiratory Cell And Molecular Biology 2008, 40: 295-304. PMID: 18776130, PMCID: PMC2645527, DOI: 10.1165/rcmb.2008-0170oc.
Bone Marrow–derived Lung Epithelial CellsKrause DS. Bone Marrow–derived Lung Epithelial Cells Annals Of The American Thoracic Society 2008, 5: 699-702. PMID: 18684720, PMCID: PMC2645262, DOI: 10.1513/pats.200803-031aw.
Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in MiceSwenson ES, Guest I, Ilic Z, Mazzeo‐Helgevold M, Lizardi P, Hardiman C, Sell S, Krause DS. Hepatocyte Nuclear Factor‐1 as Marker of Epithelial Phenotype Reveals Marrow‐Derived Hepatocytes, but Not Duct Cells, After Liver Injury in Mice Stem Cells 2008, 26: 1768-1777. PMID: 18467658, PMCID: PMC2846397, DOI: 10.1634/stemcells.2008-0148.
Bone Marrow–derived Cells and Stem Cells in Lung RepairKrause DS. Bone Marrow–derived Cells and Stem Cells in Lung Repair Annals Of The American Thoracic Society 2008, 5: 323-327. PMID: 18403327, PMCID: PMC2645242, DOI: 10.1513/pats.200712-169dr.
W1746 Embryonic Stem Cell Chimeric Mice Reveal Clonal Development of Pancreatic Acini, But Not IsletsSwenson E, Nottoli T, McGrath J, Theise N, Krause D. W1746 Embryonic Stem Cell Chimeric Mice Reveal Clonal Development of Pancreatic Acini, But Not Islets Gastroenterology 2008, 134: a-707. DOI: 10.1016/s0016-5085(08)63301-6.
Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regenerationSwenson ES, Kuwahara R, Krause DS, Theise ND. Physiological variations of stem cell factor and stromal‐derived factor‐1 in murine models of liver injury and regeneration Liver International 2008, 28: 308-318. PMID: 18290773, PMCID: PMC2846401, DOI: 10.1111/j.1478-3231.2007.01659.x.
Rectal Potential Difference and the Functional Expression of CFTR in the Gastrointestinal Epithelia in Cystic Fibrosis Mouse ModelsWEINER SA, CAPUTO C, BRUSCIA E, FERREIRA EC, PRICE JE, KRAUSE DS, EGAN ME. Rectal Potential Difference and the Functional Expression of CFTR in the Gastrointestinal Epithelia in Cystic Fibrosis Mouse Models Pediatric Research 2008, 63: 73-78. PMID: 18043508, DOI: 10.1203/pdr.0b013e31815b4bc6.
MKL1 Promotes Megakaryocytic Differentiation Via Stimulation of Serum Response Factor Target Genes.Cheng E, Renda M, Wang L, Krause D. MKL1 Promotes Megakaryocytic Differentiation Via Stimulation of Serum Response Factor Target Genes. Blood 2007, 110: 871-871. DOI: 10.1182/blood.v110.11.871.871.
MKL1 Enhances Megakaryocytic Differentiation of Primary CD34+ Cells.Renda M, Troy J, Cheng E, Wang L, Krause D. MKL1 Enhances Megakaryocytic Differentiation of Primary CD34+ Cells. Blood 2007, 110: 2218-2218. DOI: 10.1182/blood.v110.11.2218.2218.
Limitations of Green Fluorescent Protein as a Cell Lineage MarkerSwenson ES, Price JG, Brazelton T, Krause DS. Limitations of Green Fluorescent Protein as a Cell Lineage Marker Stem Cells 2007, 25: 2593-2600. PMID: 17615263, DOI: 10.1634/stemcells.2007-0241.
The commonly used β-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosisGuo JK, Cheng EC, Wang L, Swenson ES, Ardito TA, Kashgarian M, Cantley LG, Krause DS. The commonly used β-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis Transgenic Research 2007, 16: 829-834. PMID: 17594530, DOI: 10.1007/s11248-007-9107-x.
Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental MimicryCogle CR, Theise ND, Fu D, Ucar D, Lee S, Guthrie SM, Lonergan J, Rybka W, Krause DS, Scott EW. Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry Stem Cells 2007, 25: 1881-1887. PMID: 17478582, DOI: 10.1634/stemcells.2007-0163.
Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammationHerzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, Krause DS. Lung‐specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation The FASEB Journal 2007, 21: 2592-2601. PMID: 17449722, DOI: 10.1096/fj.06-7861com.
Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid DifferentiationMa X, Renda MJ, Wang L, Cheng EC, Niu C, Morris SW, Chi AS, Krause DS. Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation Molecular And Cellular Biology 2007, 27: 3056-3064. PMID: 17283045, PMCID: PMC1899951, DOI: 10.1128/mcb.01339-06.
Circulating stem cells in extremely preterm neonatesBizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.
Rbm15 Affects Notch Signaling and Myelopoiesis.Renda M, Cheng E, Wang L, Ma X, Krause D. Rbm15 Affects Notch Signaling and Myelopoiesis. Blood 2006, 108: 2545-2545. DOI: 10.1182/blood.v108.11.2545.2545.
Engraftment of Marrow-derived Epithelial CellsHerzog EL, Krause DS. Engraftment of Marrow-derived Epithelial Cells Annals Of The American Thoracic Society 2006, 3: 691-695. PMID: 17065375, PMCID: PMC2647654, DOI: 10.1513/pats.200605-109sf.
Engraftment of Donor‐Derived Epithelial Cells in Multiple Organs Following Bone Marrow Transplantation into Newborn MiceBruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Engraftment of Donor‐Derived Epithelial Cells in Multiple Organs Following Bone Marrow Transplantation into Newborn Mice Stem Cells 2006, 24: 2299-2308. PMID: 16794262, DOI: 10.1634/stemcells.2006-0166.
Threshold of Lung Injury Required for the Appearance of Marrow‐Derived Lung EpitheliaHerzog EL, Van Arnam J, Hu B, Krause DS. Threshold of Lung Injury Required for the Appearance of Marrow‐Derived Lung Epithelia Stem Cells 2006, 24: 1986-1992. PMID: 16868209, DOI: 10.1634/stemcells.2005-0579.
Prevention of mesangial sclerosis by bone marrow transplantationGuo J, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation Kidney International 2006, 70: 910-913. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.
SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic miceMa Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice Blood 2006, 108: 2726-2735. PMID: 16763212, PMCID: PMC1895586, DOI: 10.1182/blood-2006-02-001594.
Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantationBruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 2965-2970. PMID: 16481627, PMCID: PMC1413802, DOI: 10.1073/pnas.0510758103.
Host factors that impact the biodistribution and persistence of multipotent adult progenitor cellsTolar J, O'Shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells Blood 2006, 107: 4182-4188. PMID: 16410448, PMCID: PMC1895284, DOI: 10.1182/blood-2005-08-3289.
Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementDominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 2006, 8: 315-317. PMID: 16923606, DOI: 10.1080/14653240600855905.
1054. Hematopoietic and Non-Hematopoietic Engraftment after Bone Marrow Transplantation in Newborn MiceBruscia E, Price J, Ziegler E, Krause D. 1054. Hematopoietic and Non-Hematopoietic Engraftment after Bone Marrow Transplantation in Newborn Mice Molecular Therapy 2006, 13: s404. DOI: 10.1016/j.ymthe.2006.08.1150.
Successful Engraftment of Autologous Peripheral Blood Progenitor Cells Derived from Multiple Collections in Poor Mobilizers by Hyperstimulation with G-CSF.Wu Y, Proytcheva M, Medoff E, Seropian S, Snyder E, Krause D, Cooper D. Successful Engraftment of Autologous Peripheral Blood Progenitor Cells Derived from Multiple Collections in Poor Mobilizers by Hyperstimulation with G-CSF. Blood 2005, 106: 5508-5508. DOI: 10.1182/blood.v106.11.5508.5508.
Integration of engrafted Schwann cells into injured peripheral nerve: Axonal association and nodal formation on regenerated axonsRadtke C, Akiyama Y, Lankford KL, Vogt PM, Krause DS, Kocsis JD. Integration of engrafted Schwann cells into injured peripheral nerve: Axonal association and nodal formation on regenerated axons Neuroscience Letters 2005, 387: 85-89. PMID: 16084645, PMCID: PMC2605373, DOI: 10.1016/j.neulet.2005.06.073.
Bone Marrow Transplantation Can Attenuate the Progression of Mesangial SclerosisGuo J, Schedl A, Krause DS. Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis Stem Cells 2005, 24: 406-415. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.
Plastic Surgery Research Council 2005 Clifford C. Snyder, MD Award: Myelination of Regenerated Sciatic Nerve Fibers by Engrafted Schwann Cells Identified with Gfp and Fluorescence In-situ Hybridization (Fish) for Y ChromosomesRadtke C, Sasaki M, Vogt P, Krause D, Kocsis J. Plastic Surgery Research Council 2005 Clifford C. Snyder, MD Award: Myelination of Regenerated Sciatic Nerve Fibers by Engrafted Schwann Cells Identified with Gfp and Fluorescence In-situ Hybridization (Fish) for Y Chromosomes Plastic & Reconstructive Surgery 2005, 116: 57-58. DOI: 10.1097/00006534-200509011-00058.
The importance of National Blood Foundation fundingKrause DS. The importance of National Blood Foundation funding Transfusion 2005, 45: 67s-71s. PMID: 16086791, DOI: 10.1111/j.1537-2995.2005.00541.x.
Bone marrow plasticity revisited: protection or differentiation in the kidney tubule?Krause D, Cantley LG. Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? Journal Of Clinical Investigation 2005, 115: 1705-1708. PMID: 16007248, PMCID: PMC1159151, DOI: 10.1172/jci25540.
Engraftment of Bone Marrow‐Derived Epithelial CellsKrause DS. Engraftment of Bone Marrow‐Derived Epithelial Cells Annals Of The New York Academy Of Sciences 2005, 1044: 117-124. PMID: 15958704, DOI: 10.1196/annals.1349.015.
Engraftment of bone marrow-derived epithelial cellsVan Arnam JS, Herzog E, Grove J, Bruscia E, Ziegler E, Swenson S, Krause DS. Engraftment of bone marrow-derived epithelial cells Stem Cell Reviews And Reports 2005, 1: 21-27. PMID: 17132871, DOI: 10.1385/scr:1:1:021.
Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statementHorwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC, Deans RJ, Krause DS, Keating A. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement Cytotherapy 2005, 7: 393-395. PMID: 16236628, DOI: 10.1080/14653240500319234.
The Dynamics of Chromatin Modification during RA Induced Promyelocyte Differentiation.Harris R, Krause D. The Dynamics of Chromatin Modification during RA Induced Promyelocyte Differentiation. Blood 2004, 104: 4191-4191. DOI: 10.1182/blood.v104.11.4191.4191.
Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of InjuryAbbott JD, Huang Y, Liu D, Hickey R, Krause DS, Giordano FJ. Stromal Cell–Derived Factor-1α Plays a Critical Role in Stem Cell Recruitment to the Heart After Myocardial Infarction but Is Not Sufficient to Induce Homing in the Absence of Injury Circulation 2004, 110: 3300-3305. PMID: 15533866, DOI: 10.1161/01.cir.0000147780.30124.cf.
Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound HealingBorue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS. Bone Marrow-Derived Cells Contribute to Epithelial Engraftment during Wound Healing American Journal Of Pathology 2004, 165: 1767-1772. PMID: 15509544, PMCID: PMC1618655, DOI: 10.1016/s0002-9440(10)63431-1.
Lack of a Fusion Requirement for Development of Bone Marrow-Derived EpitheliaHarris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a Fusion Requirement for Development of Bone Marrow-Derived Epithelia Science 2004, 305: 90-93. PMID: 15232107, DOI: 10.1126/science.1098925.
Plasticity of Bone Marrow–Derived Stem CellsGrove JE, Bruscia E, Krause DS. Plasticity of Bone Marrow–Derived Stem Cells Stem Cells 2004, 22: 487-500. PMID: 15277695, DOI: 10.1634/stemcells.22-4-487.
Lineage specificity of gene expression patternsKluger Y, Tuck DP, Chang JT, Nakayama Y, Poddar R, Kohya N, Lian Z, Nasr A, Halaban HR, Krause DS, Zhang X, Newburger PE, Weissman SM. Lineage specificity of gene expression patterns Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6508-6513. PMID: 15096607, PMCID: PMC404075, DOI: 10.1073/pnas.0401136101.
A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftmentAngelopoulou MK, Rinder H, Wang C, Burtness B, Cooper DL, Krause DS. A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment Transfusion 2004, 44: 555-566. PMID: 15043572, DOI: 10.1111/j.1537-2995.2004.03285.x.
A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agentsLerro KA, Medoff E, Wu Y, Seropian SE, Snyder E, Krause D, Cooper DL. A simplified approach to stem cell mobilization in multiple myeloma patients not previously treated with alkylating agents Bone Marrow Transplantation 2003, 32: 1113-1117. PMID: 14647264, DOI: 10.1038/sj.bmt.1704286.
Plasticity of marrow-derived stem cellsHerzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells Blood 2003, 102: 3483-3493. PMID: 12893756, DOI: 10.1182/blood-2003-05-1664.
Bone marrow stem cells contribute to repair of the ischemically injured renal tubuleKale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG. Bone marrow stem cells contribute to repair of the ischemically injured renal tubule Journal Of Clinical Investigation 2003, 112: 42-49. PMID: 12824456, PMCID: PMC162291, DOI: 10.1172/jci17856.
Xenogeneic studies of human stem cell plasticityKrause D. Xenogeneic studies of human stem cell plasticity Blood 2003, 101: 3762-3764. DOI: 10.1182/blood-2003-03-0767.
Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID miceAngelopoulou M, Novelli E, Grove JE, Rinder HM, Civin C, Cheng L, Krause DS. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice Experimental Hematology 2003, 31: 413-420. PMID: 12763140, DOI: 10.1016/s0301-472x(03)00042-0.
Comment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells"Theise ND, Krause DS, Sharkis S. Comment on "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells" Science 2003, 299: 1317a-1317. PMID: 12610282, DOI: 10.1126/science.1078412.
Bone marrow to liver: the blood of PrometheusTheise ND, Krause DS. Bone marrow to liver: the blood of Prometheus Seminars In Cell And Developmental Biology 2002, 13: 411-417. PMID: 12468241, DOI: 10.1016/s1084952102001283.
Marrow-Derived Cells as Vehicles for Delivery of Gene Therapy to Pulmonary EpitheliumGrove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. Marrow-Derived Cells as Vehicles for Delivery of Gene Therapy to Pulmonary Epithelium American Journal Of Respiratory Cell And Molecular Biology 2002, 27: 645-651. PMID: 12444022, DOI: 10.1165/rcmb.2002-0056rc.
Radiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrowTheise ND, Henegariu O, Grove J, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. Radiation pneumonitis in mice A severe injury model for pneumocyte engraftment from bone marrow Experimental Hematology 2002, 30: 1333-1338. PMID: 12423687, DOI: 10.1016/s0301-472x(02)00931-1.
BM-derived stem cells for the treatment of nonhematopoietic diseasesKrause DS. BM-derived stem cells for the treatment of nonhematopoietic diseases Cytotherapy 2002, 4: 503-506. PMID: 12568982, DOI: 10.1080/146532402761624629.
Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA libraryMa X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, Perkins AS. Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library Blood 2002, 100: 833-844. PMID: 12130493, DOI: 10.1182/blood.v100.3.833.
Plasticity of marrow-derived stem cells.Krause DS. Plasticity of marrow-derived stem cells. Gene Therapy 2002, 9: 754-8. PMID: 12032704, DOI: 10.1038/sj.gt.3301760.
Regulation of hematopoietic stem cell fateKrause DS. Regulation of hematopoietic stem cell fate Oncogene 2002, 21: 3262-3269. PMID: 12032767, DOI: 10.1038/sj.onc.1205316.
Toward a new paradigm of cell plasticityTheise N, Krause D. Toward a new paradigm of cell plasticity Leukemia 2002, 16: 542-548. PMID: 11960330, DOI: 10.1038/sj.leu.2402445.
Multipotent human cells expand indefinitelyKrause D. Multipotent human cells expand indefinitely Blood 2001, 98: 2595-2595. DOI: 10.1182/blood.v98.9.2595.
Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34+ cellsBurgess J, Mills B, Griffith M, Mansour V, Weaver CH, Schwartzberg LS, Snyder EL, Krause DS, Yanovich S, Prilutskaya M, Umiel T, Moss TJ. Breast tumor contamination of PBSC harvests: tumor depletion by positive selection of CD34+ cells Cytotherapy 2001, 3: 285-294. PMID: 12171717, DOI: 10.1080/146532401317070925.
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem CellKrause D, Theise N, Collector M, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis S. Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell Cell 2001, 105: 369-377. PMID: 11348593, DOI: 10.1016/s0092-8674(01)00328-2.
Suggestions for a New Paradigm of Cell Differentiative Potential>Theise N, Krause D. Suggestions for a New Paradigm of Cell Differentiative Potential> Blood Cells Molecules And Diseases 2001, 27: 625-631. PMID: 11482876, DOI: 10.1006/bcmd.2001.0425.
Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet productionPerez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.
Hematopoietic Stem Cells Can Be CD34+ or CD34-Donnelly D, Krause D. Hematopoietic Stem Cells Can Be CD34+ or CD34- Leukemia & Lymphoma 2001, 40: 221-234. PMID: 11426544, DOI: 10.3109/10428190109057921.
Chapter 21 Mononuclear Cell PreparationsValleca M, Debelak J, Krause D. Chapter 21 Mononuclear Cell Preparations 2001, 179-186. DOI: 10.1016/b978-012348775-9/50072-7.
Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCsDebelak J, Shlomchik M, Snyder E, Cooper D, Seropian S, McGuirk J, Smith B, Krause D. Isolation and flow cytometric analysis of T‐cell‐depleted CD34+ PBPCs Transfusion 2000, 40: 1475-1481. PMID: 11134567, DOI: 10.1046/j.1537-2995.2000.40121475.x.
ReplyTheise N, Krause D, Mehal W, Illei P. Reply Hepatology 2000, 32: 1181. DOI: 10.1016/s0270-9139(00)80044-0.
Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation.Marshall N, Howe J, Formica R, Krause D, Wagner J, Berliner N, Crouch J, Pilip I, Cooper D, Blazar B, Seropian S, Pamer E. Rapid reconstitution of Epstein-Barr virus-specific T lymphocytes following allogeneic stem cell transplantation. Blood 2000, 96: 2814-21. PMID: 11023516, DOI: 10.1182/blood.v96.8.2814.h8002814_2814_2821.
Rapid reconstitution of Epstein-Barr virus–specific T lymphocytes following allogeneic stem cell transplantationMarshall N, Howe J, Formica R, Krause D, Wagner J, Berliner N, Crouch J, Pilip I, Cooper D, Blazar B, Seropian S, Pamer E. Rapid reconstitution of Epstein-Barr virus–specific T lymphocytes following allogeneic stem cell transplantation Blood 2000, 96: 2814-2821. DOI: 10.1182/blood.v96.8.2814.
Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start siteTaranenko N, Krause D. Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site Experimental Hematology 2000, 28: 974-984. PMID: 10989198, DOI: 10.1016/s0301-472x(00)00492-6.
Liver from bone marrow in humansTheise N, Nimmakayalu M, Gardner R, Illei P, Morgan G, Teperman L, Henegariu O, Krause D. Liver from bone marrow in humans Hepatology 2000, 32: 11-16. PMID: 10869283, DOI: 10.1053/jhep.2000.9124.
Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trialYanovich S, Mitsky P, Cornetta K, Maziarz R, Rosenfeld C, Krause D, Lotz J, Bitran J, Williams S, Preti R, Somlo G, Burtness B, Mills B. Transplantation of CD34+ peripheral blood cells selected using a fully automated immunomagnetic system in patients with high-risk breast cancer: results of a prospective randomized multicenter clinical trial Bone Marrow Transplantation 2000, 25: 1165-1174. PMID: 10849529, DOI: 10.1038/sj.bmt.1702415.
Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablationTheise N, Badve S, Saxena R, Henegariu O, Sell S, Crawford J, Krause D. Derivation of hepatocytes from bone marrow cells in mice after radiation‐induced myeloablation Hepatology 2000, 31: 235-240. PMID: 10613752, DOI: 10.1002/hep.510310135.
A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.Radomska H, Satterthwaite A, Taranenko N, Narravula S, Krause D, Tenen D. A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene. Blood 1999, 94: 3772-80. PMID: 10572091, DOI: 10.1182/blood.v94.11.3772.423k19_3772_3780.
A Nuclear Factor Y (NFY) Site Positively Regulates the Human CD34 Stem Cell GeneRadomska H, Satterthwaite A, Taranenko N, Narravula S, Krause D, Tenen D. A Nuclear Factor Y (NFY) Site Positively Regulates the Human CD34 Stem Cell Gene Blood 1999, 94: 3772-3780. DOI: 10.1182/blood.v94.11.3772.
Functional activity of murine CD34+and CD34− hematopoietic stem cell populationsDonnelly D, Zelterman D, Sharkis S, Krause D. Functional activity of murine CD34+and CD34− hematopoietic stem cell populations Experimental Hematology 1999, 27: 788-796. PMID: 10340393, DOI: 10.1016/s0301-472x(99)00032-6.
A phase I study of paclitaxel for mobilization of peripheral blood progenitor cellsBurtness B, Psyrri A, Rose M, D’Andrea E, Staugaard-Hahn C, Henderson-Bakas M, Clark M, Mechanic S, Krause D, Snyder E, Cooper R, Abrantes J, Corringham R, Deisseroth A, Cooper D. A phase I study of paclitaxel for mobilization of peripheral blood progenitor cells Bone Marrow Transplantation 1999, 23: 311-315. PMID: 10100573, DOI: 10.1038/sj.bmt.1701589.
Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.Lawson ND, Krause DS, Berliner N. Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines. Experimental Hematology 1998, 26: 1178-85. PMID: 9808058.
High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre studyChabannon C, Cornetta K, Lotz J, Rosenfeld C, Shlomchik M, Yanovitch S, Marolleau J, Sledge G, Novakovitch G, Srour E, Burtness B, Camerlo J, Gravis G, Lee-Fischer J, Faucher C, Chabbert I, Krause D, Maraninchi D, Mills B, Kunkel L, Oldham F, Blaise D, Viens P. High-dose chemotherapy followed by reinfusion of selected CD34+ peripheral blood cells in patients with poor-prognosis breast cancer: a randomized multicentre study British Journal Of Cancer 1998, 78: 913-921. PMID: 9764583, PMCID: PMC2063121, DOI: 10.1038/bjc.1998.601.
CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb.Krause DS, Mucenski ML, Lawler AM, May WS. CD34 expression by embryonic hematopoietic and endothelial cells does not require c-Myb. Experimental Hematology 1998, 26: 1086-92. PMID: 9766450.
Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous TransplantationGarcia-Sanchez F, Pizzorno G, Fu SQ, Nanakorn T, Krause DS, Liang J, Adams E, Leffert JJ, Yin LH, Cooperberg MR, Hanania E, Wang WL, Won JH, Peng XY, Cote R, Brown R, Burtness B, Giles R, Crystal R, Deisseroth AB. Cytosine Deaminase Adenoviral Vector and 5-Fluorocytosine Selectively Reduce Breast Cancer Cells 1 Million-Fold When They Contaminate Hematopoietic Cells: A Potential Purging Method for Autologous Transplantation Blood 1998, 92: 672-682. PMID: 9657770, DOI: 10.1182/blood.v92.2.672.
Gotta find GATA a friendKrause D, Perkins A. Gotta find GATA a friend Nature Medicine 1997, 3: 960-961. PMID: 9288719, DOI: 10.1038/nm0997-960.
Regulation of CD34 expression in differentiating M1 cells.Krause DS, Kapadia SU, Raj NB, May WS. Regulation of CD34 expression in differentiating M1 cells. Experimental Hematology 1997, 25: 1051-61. PMID: 9293902.
Use of an adenoviral vector containing the prodrug activation unit cytosine deaminase for purging bone marrow from breast cancer cellsPizzorno G, Garcia-Sanchez F, Krause D, Leffert J, Adams E, Crystal R, Deisseroth A. Use of an adenoviral vector containing the prodrug activation unit cytosine deaminase for purging bone marrow from breast cancer cells Clinical Biochemistry 1997, 30: 274. DOI: 10.1016/s0009-9120(97)87764-8.
Multilineage gene expression precedes commitment in the hemopoietic system.Hu M, Krause D, Greaves M, Sharkis S, Dexter M, Heyworth C, Enver T. Multilineage gene expression precedes commitment in the hemopoietic system. Genes & Development 1997, 11: 774-785. PMID: 9087431, DOI: 10.1101/gad.11.6.774.
CD34: structure, biology, and clinical utility.Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996, 87: 1-13. PMID: 8547630, DOI: 10.1182/blood.v87.1.1.1.
CD34: structure, biology, and clinical utility [see comments]Krause D, Fackler M, Civin C, May W. CD34: structure, biology, and clinical utility [see comments] Blood 1996, 87: 1-13. DOI: 10.1182/blood.v87.1.1.bloodjournal8711.
Full-length but not truncated CD34 inhibits hematopoietic cell differentiation of M1 cells.Fackler M, Krause D, Smith O, Civin C, May W. Full-length but not truncated CD34 inhibits hematopoietic cell differentiation of M1 cells. Blood 1995, 85: 3040-7. PMID: 7538813, DOI: 10.1182/blood.v85.11.3040.bloodjournal85113040.
Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells.Krause D, Ito T, Fackler M, Smith O, Collector M, Sharkis S, May W. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells. Blood 1994, 84: 691-701. PMID: 7519070, DOI: 10.1182/blood.v84.3.691.691.
Characterization of murine CD34, a marker for hematopoietic progenitor and stem cellsKrause D, Ito T, Fackler M, Smith O, Collector M, Sharkis S, May W. Characterization of murine CD34, a marker for hematopoietic progenitor and stem cells Blood 1994, 84: 691-701. DOI: 10.1182/blood.v84.3.691.bloodjournal843691.
Acute aspirin overdose: mechanisms of toxicity.Krause DS, Wolf BA, Shaw LM. Acute aspirin overdose: mechanisms of toxicity. Therapeutic Drug Monitoring 1992, 14: 441-51. PMID: 1485363, DOI: 10.1097/00007691-199212000-00001.
Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected.Krause DS, Deutsch C. Cyclic AMP directly inhibits IL-2 receptor expression in human T cells: expression of both p55 and p75 subunits is affected. Journal Of Immunology (Baltimore, Md. : 1950) 1991, 146: 2285-96. PMID: 1848580.
Forskolin effects on the voltage-gated K+ conductance of human T cells.Krause D, Lee SC, Deutsch C. Forskolin effects on the voltage-gated K+ conductance of human T cells. Pflügers Archiv : European Journal Of Physiology 1988, 412: 133-40. PMID: 2845353.
Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester.Deutsch C, Krause D, Lee SC. Voltage-gated potassium conductance in human T lymphocytes stimulated with phorbol ester. The Journal Of Physiology 1986, 372: 405-23. PMID: 3487642, PMCID: PMC1192770, DOI: 10.1113/jphysiol.1986.sp016016.
URL for full list of published work in publicly available database, My Bibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/diane.krause.1/bibliography/40319867/public/?sort=date&direction=ascending URL for full list of published work in publicly available database, My Bibliography: http://www.ncbi.nlm.nih.gov/sites/myncbi/diane.krause.1/bibliography/40319867/public/?sort=date&direction=ascending

Edit Profile

Diane Krause, MD, PhD

Contact Information

Mailing Address

Related Links

Patient Care

Research & Publications

Biography

News

Research Summary

Extensive Research Description

Coauthors

Research Interests

Selected Publications