The Dean's Workshops series brings together physicians and scientists from across the School of Medicine, the Yale medical center, and Yale University to address topics of critical importance in advancing biomedical research and patient care.
The workshops serve as a forum for new ideas and collaborations across disciplines.
PsychENCODE: Functional Genomics of Human Brain Development and Neuropsychiatric Disorders
Jane Ellen Hope Building, H-110
315 Cedar St., New Haven
The human brain is responsible for our species’ most unique traits, but also underlies our susceptibility to neuropsychiatric disorders. Healthy brain development relies on the precise spatiotemporal regulation of the transcriptome, a feat that is carried out by myriad non-coding regulatory elements. Thus, understanding neuropsychiatric disease requires the identification and characterization of these regulatory programs, which provide the link between genetic variation and disease risk. However, our ability to make these connections is significantly impeded by our lack of a comprehensive understanding of the regulatory and epigenomic landscape of the human brain. With this goal in mind, the PsychENCODE Consortium was formed by the National Institute of Mental Health in 2015 to identify genomic elements active within the human brain throughout the span of development, and to characterize their role in evolution and neuropsychiatric disease. At this workshop, members of the consortium will discuss their recent accomplishments as highlighted in the Science PsychENCODE collection.
9:30 a.m. Welcoming Remarks
John Krystal, MD Department of Psychiatry and of Neuroscience, Yale School of Medicine
9:40 a.m. Introduction to the PsychENCODE Consortium
Alexander Arguello, PhD National Institute of Mental Health
10:10 a.m. Topics In PsychENCODE Research
Nenad Sestan, MD, PhD Department of Neuroscience, of Comparative Medicine, of Genetics, and of Psychiatry, Yale School of Medicine
10:40 a.m. Coffee Break
- Flora Vaccarino, MD Yale Child Study Center and Department of Neuroscience, Yale School of Medicine
- Mark Gerstein, PhD Department of Molecular Biophysics and Biochemistry, of Computer Science and of Statistics and Data Science, Yale University
12 p.m. Lunch Break
1:00 p.m. Topics IN PsychENCODE Research
- Donna Werling, PhD Department of Psychiatry, University of California, San Francisco
- Kristen Brennand, PhD Department of Neuroscience, of Genetics and Genomic Sciences, and of Psychiatry, Icahn School of Medicine at Mount Sinai
2:00 p.m. Plenary Speaker
Raquel Gur, MD, PhD Department of Psychiatry, of Radiology, and of Neurology Perelman School of Medicine, University of Pennsylvania