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David Matuskey, MD

Associate Professor of Radiology and Biomedical Imaging; Director, NeuroPET Imaging Program, Radiology and Biomedical Imaging; Medical Director, Yale Positron Emission Tomography (PET) Center

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Research Summary

I am a board certified psychiatrist and neuropsychiatrist with research work that has been translational in nature and focused on elucidating the underlying pathology of conditions such as Autism Spectrum Disorder, substance abuse and Parkinson's disease with an aim to find effective clinical treatments guided by molecular neuroimaging. Studies have included using in-vivo PET imaging to investigate the role of receptors such as dopamine D3, serotonin 1B and 6, MGlur5 and kappa, neuroinflammation, and most recently, synaptic density (SV2A) in clinical and nonclinical populations. Ongoing interests include imaging addiction and neuropsychiatric disorders and demographic, social and environmental factors influencing our brain.

Coauthors

Research Interests

Autistic Disorder; Mental Disorders; Parkinson Disease; Social Class; Meditation; Essential Tremor; Molecular Imaging; Frontotemporal Dementia; Neuropsychiatry; Neuroimaging; Addiction Medicine

Public Health Interests

Global Health; Mental Health

Selected Publications

Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults.Matuskey D, Gallezot J, Nabulsi N, Henry S, Torres K, Dias M, Angarita G, Huang Y, Shoaf S, Carson R, Mehrotra S. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal Of Psychopharmacology 2022, 2698811221140008. PMID: 36515395, DOI: 10.1177/02698811221140008.
Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorderHolmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in quantification of the metabotropic glutamate receptor 5 (mGluR5) across bipolar disorder and major depressive disorder Biological Psychiatry 2022 DOI: 10.1016/j.biopsych.2022.10.018.
D3 Receptors and PET Imaging.Koohsari S, Yang Y, Matuskey D. D3 Receptors and PET Imaging. Current Topics In Behavioral Neurosciences 2022 PMID: 35711027, DOI: 10.1007/7854_2022_374.
P204. Role of Kappa Opioid Receptor Availability in Borderline Personality Disorder and Suicidal Behavior: Preliminary Results From an in Vivo [11C]EKAP PET StudyDavis M, Wilson O, DeBonee S, Nabulsi N, Matuskey D, Esterlis I. P204. Role of Kappa Opioid Receptor Availability in Borderline Personality Disorder and Suicidal Behavior: Preliminary Results From an in Vivo [11C]EKAP PET Study Biological Psychiatry 2022, 91: s169-s170. DOI: 10.1016/j.biopsych.2022.02.438.
P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSDHillmer A, Davis M, Esterlis I, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSD Biological Psychiatry 2022, 91: s351. DOI: 10.1016/j.biopsych.2022.02.883.
Relationships between dopamine D2/3 receptor availability and social-environmental factors in humansCalakos KC, Rusowicz A, Pittman B, Gallezot JD, Potenza MN, Cosgrove KP, Matuskey D. Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans Neuroscience Letters 2022, 771: 136463. PMID: 35051435, PMCID: PMC8821418, DOI: 10.1016/j.neulet.2022.136463.
Looking Back at the Next 40 Years of ASD Neuroscience ResearchMcPartland JC, Lerner MD, Bhat A, Clarkson T, Jack A, Koohsari S, Matuskey D, McQuaid GA, Su WC, Trevisan DA. Looking Back at the Next 40 Years of ASD Neuroscience Research Journal Of Autism And Developmental Disorders 2021, 51: 4333-4353. PMID: 34043128, PMCID: PMC8542594, DOI: 10.1007/s10803-021-05095-5.
Imaging the Effect of Ketamine on Synaptic (SV2A) DensityHolmes S, Finnema S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Angarita G, Duman R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
Morphine Induces a Neuroimmune Response in Healthy Volunteers: Implications for Opioid Use DisorderWoodcock E, Woodcock E, Angarita G, Angarita G, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Hillmer A, Carson R, Cosgrove K. Morphine Induces a Neuroimmune Response in Healthy Volunteers: Implications for Opioid Use Disorder Biological Psychiatry 2021, 89: s252-s253. DOI: 10.1016/j.biopsych.2021.02.632.
PET Imaging of Synaptic Vesicle Protein 2AFinnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
Further in vivo characterization of [11C]‐(+)‐PHNO uptake into a retina‐like region of interest in humansCaravaggio F, Worhunsky P, Graff‐Guerrero A, Matuskey D. Further in vivo characterization of [11C]‐(+)‐PHNO uptake into a retina‐like region of interest in humans Synapse 2019, 74: e22135. PMID: 31553807, DOI: 10.1002/syn.22135.
Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET studyTuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Collste K, Gallezot J, Hillmer A, Huang Y, Huang Y, Höglund C, Höglund C, Johansson J, Johansson J, Jucaite A, Jucaite A, Lampa J, Lampa J, Nabulsi N, Pittman B, Pittman B, Sandiego C, Sandiego C, Stenkrona P, Stenkrona P, Rinne J, Rinne J, Matuskey D, Cervenka S, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2329-2338. PMID: 31363804, PMCID: PMC6717599, DOI: 10.1007/s00259-019-04403-7.
Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokersZakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.
In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideationDavis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
F33. In Vivo Brain Imaging of 11beta-Hydroxysteroid Dehydrogenase, a Marker of Cortisol Production, in PTSDBhatt S, Matuskey D, Rusowicz A, Southwick S, Carson R, Hillmer A, Huang H, Cosgrove K. F33. In Vivo Brain Imaging of 11beta-Hydroxysteroid Dehydrogenase, a Marker of Cortisol Production, in PTSD Biological Psychiatry 2019, 85: s225. DOI: 10.1016/j.biopsych.2019.03.570.
142. Synaptic Density Alterations are Associated With Depression Severity and Network AlterationsHolmes S, Scheinost D, Finnema S, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Angarita G, Pietrzak R, Duman R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations Biological Psychiatry 2019, 85: s59. DOI: 10.1016/j.biopsych.2019.03.156.
F83. Differential Effects of Ketamine on Mood Symptoms and Cognitive Function in MDD and PTSDDavis M, Pietrzak R, Maruff P, DellaGioia N, Matuskey D, Esterlis I. F83. Differential Effects of Ketamine on Mood Symptoms and Cognitive Function in MDD and PTSD Biological Psychiatry 2019, 85: s244-s245. DOI: 10.1016/j.biopsych.2019.03.620.
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography studyMartinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study Neuropsychopharmacology 2019, 44: 1720-1727. PMID: 31026862, PMCID: PMC6785004, DOI: 10.1038/s41386-019-0398-4.
Lower synaptic density is associated with depression severity and network alterationsHolmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteersMatuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers Neuropsychopharmacology 2019, 44: 1714-1719. PMID: 30928993, PMCID: PMC6785144, DOI: 10.1038/s41386-019-0379-7.
First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1 Cerebrovascular And Brain Metabolism Reviews 2019, 40: 695-704. PMID: 30895878, PMCID: PMC7168798, DOI: 10.1177/0271678x19838633.
Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human BrainGallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.
Editorial: PET Imaging in NeuroscienceMatuskey D. Editorial: PET Imaging in Neuroscience Neuroscience Letters 2018, 691: 1-2. PMID: 30342079, DOI: 10.1016/j.neulet.2018.10.033.
Positron emission tomography imaging of the γ-aminobutyric acid systemAndersson JD, Matuskey D, Finnema SJ. Positron emission tomography imaging of the γ-aminobutyric acid system Neuroscience Letters 2018, 691: 35-43. PMID: 30102960, DOI: 10.1016/j.neulet.2018.08.010.
PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseasesCai Z, Li S, Matuskey D, Nabulsi N, Huang Y. PET imaging of synaptic density: A new tool for investigation of neuropsychiatric diseases Neuroscience Letters 2018, 691: 44-50. PMID: 30075287, PMCID: PMC6339829, DOI: 10.1016/j.neulet.2018.07.038.
2181 Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PETRadhakrishnan R, Nabulsi N, Gaiser E, Gaiser E, Gallezot J, Henry S, Planeta B, Planeta B, Lin S, Lin S, Ropchan J, Williams W, Williams W, Morris E, D’Souza D, Huang Y, Carson R, Matuskey D. 2181 Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PET Journal Of Clinical And Translational Science 2018, 2: 3-4. PMCID: PMC6799074, DOI: 10.1017/cts.2018.44.
F188. Preliminary Evidence for mGluR5 Dysregulation in Borderline Personality Disorder and Relationship to Suicidal BehaviorDavis M, Holmes S, DellaGioia N, O'Grady S, O'Grady S, Axelrod S, Axelrod S, Nabulsi N, Matuskey D, Carson R, Esterlis I. F188. Preliminary Evidence for mGluR5 Dysregulation in Borderline Personality Disorder and Relationship to Suicidal Behavior Biological Psychiatry 2018, 83: s312. DOI: 10.1016/j.biopsych.2018.02.802.
F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSDHillmer A, Esterlis I, Davis M, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSD Biological Psychiatry 2018, 83: s237-s238. DOI: 10.1016/j.biopsych.2018.02.616.
F149. Preliminary Evidence for Altered Synaptic Density and a Possible Role for Accelerated Ageing in Individuals With MDD as Measured With [11C]UCB-J PETHolmes S, Finnema S, Finnema S, Davis M, Davis M, DellaGioia N, Naganawa M, Nabulsi N, Matuskey D, Pietrzak R, Duman R, Duman R, Sanacora G, Carson R, Esterlis I. F149. Preliminary Evidence for Altered Synaptic Density and a Possible Role for Accelerated Ageing in Individuals With MDD as Measured With [11C]UCB-J PET Biological Psychiatry 2018, 83: s296. DOI: 10.1016/j.biopsych.2018.02.763.
Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PETRadhakrishnan R, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Williams W, Morris E, D'Souza DC, Huang Y, Carson RE, Matuskey D. Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET Journal Of Nuclear Medicine 2018, 59: 1445-1450. PMID: 29626125, PMCID: PMC6126437, DOI: 10.2967/jnumed.117.206516.
Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional EvidenceHolmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and Prefrontal Cortical Alterations in PTSD: Structural and Functional Evidence Chronic Stress 2018, 2: 2470547018786390. PMID: 30035247, PMCID: PMC6054445, DOI: 10.1177/2470547018786390.
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive DisorderScheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET StudySandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study Neuropsychopharmacology 2017, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.
Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humansFinnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans Cerebrovascular And Brain Metabolism Reviews 2017, 38: 2041-2052. PMID: 28792356, PMCID: PMC6259313, DOI: 10.1177/0271678x17724947.
Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidenceHolmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Friedman M, Kowall N, Kowall N, Brady C, Brady C, McKee A, McKee A, Stein T, Stein T, Huber B, Huber B, Kaloupek D, Kaloupek D, Alvarez V, Alvarez V, Benedek D, Benedek D, Ursano R, Ursano R, Williamson D, Williamson D, Cruz D, Cruz D, Young K, Young K, Duman R, Duman R, Krystal J, Krystal J, Mash D, Mash D, Hardegree M, Hardegree M, Serlin G, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress DisorderDavis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging StudyEsterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measuresDavis MT, DellaGioia N, Matuskey D, Harel B, Maruff P, Pietrzak RH, Esterlis I. Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures Journal Of Affective Disorders 2017, 218: 82-85. PMID: 28460315, PMCID: PMC6457447, DOI: 10.1016/j.jad.2017.04.064.
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depressionEsterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression Molecular Psychiatry 2017, 23: 824-832. PMID: 28397841, PMCID: PMC5636649, DOI: 10.1038/mp.2017.58.
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging StudyAbdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 449-456. PMID: 28993818, PMCID: PMC5630181, DOI: 10.1016/j.bpsc.2017.03.019.
Poster Number: EI 39 Investigating Age Related Associations of Metabotropic Glutamate Receptor 5 Density Using [18F]FPEB and PETMecca A, Rogers K, Rogers K, Jacobs Z, Jacobs Z, McDonald J, McDonald J, Michalak H, Michalak H, DellaGioia N, Nabulsi N, Matuskey D, Esterlis I, Carson R, van Dyck C. Poster Number: EI 39 Investigating Age Related Associations of Metabotropic Glutamate Receptor 5 Density Using [18F]FPEB and PET American Journal Of Geriatric Psychiatry 2017, 25: s96-s97. DOI: 10.1016/j.jagp.2017.01.110.
Regional and network-based alterations in D2/D3 receptor availability in cocaine use disorderWorhunsky P, Matuskey D, Gallezot J, Nabulsi N, Angarita G, Angarita G, Calhoun V, Malison R, Malison R, Potenza M, Carson R. Regional and network-based alterations in D2/D3 receptor availability in cocaine use disorder Drug And Alcohol Dependence 2017, 171: e219. DOI: 10.1016/j.drugalcdep.2016.08.598.
Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorderWorhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE. Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder NeuroImage 2017, 148: 343-351. PMID: 28110088, PMCID: PMC5344702, DOI: 10.1016/j.neuroimage.2017.01.045.
Imaging synaptic density in the living human brainFinnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain Science Translational Medicine 2016, 8: 348ra96. PMID: 27440727, DOI: 10.1126/scitranslmed.aaf6667.
Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNOGaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Elevated Dopamine D2/3 Receptor Availability in Obese Individuals: A PET Imaging Study with [11C](+)PHNO Neuropsychopharmacology 2016, 41: 3042-3050. PMID: 27374277, PMCID: PMC5101552, DOI: 10.1038/npp.2016.115.
Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteersMatuskey D, Worhunksy P, Correa E, Pittman B, Gallezot JD, Nabulsi N, Ropchan J, Sreeram V, Gudepu R, Gaiser E, Cosgrove K, Ding YS, Potenza MN, Huang Y, Malison RT, Carson RE. Age-related changes in binding of the D2/3 receptor radioligand [11C](+)PHNO in healthy volunteers NeuroImage 2016, 130: 241-247. PMID: 26876475, PMCID: PMC4808424, DOI: 10.1016/j.neuroimage.2016.02.002.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PETSandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O’Connor K, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 12468-12473. PMID: 26385967, PMCID: PMC4603509, DOI: 10.1073/pnas.1511003112.
S.14.02 Dopaminergic function, choice impulsivity and cocaine use in cocaine-dependent humansPotenza M, Worhunsky P, Kober H, Angarita G, Gallezot J, Matuskey D, Nabusi N, Luhmann C, Lee D, Ding Y, Carson R, Malison R. S.14.02 Dopaminergic function, choice impulsivity and cocaine use in cocaine-dependent humans European Neuropsychopharmacology 2015, 25: s131-s132. DOI: 10.1016/s0924-977x(15)30073-0.
A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [11C](+)PHNOMatuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT. A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [11C](+)PHNO Drug And Alcohol Dependence 2015, 154: 167-173. PMID: 26164205, PMCID: PMC4536182, DOI: 10.1016/j.drugalcdep.2015.06.039.
Memory Reconsolidation for Treatment-Resistant Aggression and Self-Injurious BehaviorsMatuskey D, Sondik T. Memory Reconsolidation for Treatment-Resistant Aggression and Self-Injurious Behaviors Journal Of Clinical Psychopharmacology 2015, 35: 104-105. PMID: 25502487, DOI: 10.1097/jcp.0000000000000264.
Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test–retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943 European Journal Of Nuclear Medicine And Molecular Imaging 2014, 42: 468-477. PMID: 25427881, DOI: 10.1007/s00259-014-2958-5.
The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy AdultsFarr OM, Hu S, Matuskey D, Zhang S, Abdelghany O, Li CS. The Effects of Methylphenidate on Cerebral Activations to Salient Stimuli in Healthy Adults Experimental And Clinical Psychopharmacology 2014, 22: 154-165. PMID: 24188171, PMCID: PMC4105943, DOI: 10.1037/a0034465.
Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+)PHNOMatuskey D, Gallezot JD, Pittman B, Williams W, Wanyiri J, Gaiser E, Lee DE, Hannestad J, Lim K, Zheng MQ, Lin SF, Labaree D, Potenza MN, Carson RE, Malison RT, Ding YS. Dopamine D3 receptor alterations in cocaine-dependent humans imaged with [11C](+)PHNO Drug And Alcohol Dependence 2014, 139: 100-105. PMID: 24717909, PMCID: PMC4071607, DOI: 10.1016/j.drugalcdep.2014.03.013.
Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent HumansMatuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT. Reductions in Brain 5-HT1B Receptor Availability in Primarily Cocaine-Dependent Humans Biological Psychiatry 2013, 76: 816-822. PMID: 24433854, PMCID: PMC4037398, DOI: 10.1016/j.biopsych.2013.11.022.
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individualsMatuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.
Gray matter correlates of alcohol expectancyIde JS, Zhang S, Hu S, Matuskey D, Bednarski SR, Erdman E, Farr OM, Li C. Gray matter correlates of alcohol expectancy Addiction Biology 2013, 19: 895-906. PMID: 23461484, PMCID: PMC3681829, DOI: 10.1111/adb.12046.
A single-day paradigm of self-regulated human cocaine administrationMatuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration Pharmacology Biochemistry And Behavior 2012, 103: 95-101. PMID: 22922558, PMCID: PMC3652339, DOI: 10.1016/j.pbb.2012.08.009.
Age Effects on Serotonin Receptor 1B as Assessed by PETMatuskey D, Pittman B, Planeta-Wilson B, Walderhaug E, Henry S, Gallezot JD, Nabulsi N, Ding YS, Bhagwagar Z, Malison R, Carson RE, Neumeister A. Age Effects on Serotonin Receptor 1B as Assessed by PET Journal Of Nuclear Medicine 2012, 53: 1411-1414. PMID: 22851636, PMCID: PMC3690814, DOI: 10.2967/jnumed.112.103598.
A multistudy analysis of the effects of early cocaine abstinence on sleepMatuskey D, Pittman B, Forselius E, Malison RT, Morgan PT. A multistudy analysis of the effects of early cocaine abstinence on sleep Drug And Alcohol Dependence 2010, 115: 62-66. PMID: 21144676, PMCID: PMC3081928, DOI: 10.1016/j.drugalcdep.2010.10.015.
Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patientsLi CS, Morgan PT, Matuskey D, Abdelghany O, Luo X, Chang JL, Rounsaville BJ, Ding YS, Malison RT. Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14455-14459. PMID: 20660731, PMCID: PMC2922598, DOI: 10.1073/pnas.1002467107.

Clinical Trials

Conditions	Study Title
Addictive Behaviors	Brain Imaging and Synaptic Plasticity
Mental Health & Behavioral Research	M1 Schizophrenia PET Study
Alzheimer's Disease	A Study to Test the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Patients With Mild Cognitive Impairment or Mild Alzheimer's Disease (AD)
Diseases of the Nervous System	Meditation and Synaptic Density
Diseases of the Nervous System	Study of Safety and of the Mechanism of BLZ945 in ALS Patients
Mental Health & Behavioral Research; Alzheimer's Disease	Ketamine for the Treatment of Depression in Parkinson's Disease
Alzheimer's Disease	AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
Alzheimer's Disease	A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
Men's Health; Women's Health	Evaluating the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923
Alzheimer's Disease	A Randomized, Double-Blind, Placebo controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an anti-tau Monoclonal Antibody, in Participants with Early Alzheimer's Disease
Mental Health & Behavioral Research	HPA axis function in the brains of PTSD, Trauma Exposed, or Otherwise Healthy research participants utilizing PET and MRI imaging
Diseases of the Endocrine System; Genetics - Adult	A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease (GATEWAY)
Diseases of the Nervous System; HIV/AIDS; Infectious Diseases; COVID-19 Inpatient; COVID-19 Outpatient	HIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Addictive Behaviors	PET Imaging of Microglia with [11C]PBR28 in Opioid Dependent and Healthy Control Subjects
Mental Health & Behavioral Research	Eligibility for Participation in Neuroimaging Studies
Diseases of the Lung; Diseases of the Respiratory Systems	Safety, Tolerability, Kinetics, and Repeatability of the Novel LPA1 PET Ligand 18F-BMS-986327
Child Development & Autism	PET Imaging Study for Young Adults with ASD
Diseases of the Nervous System	Imaging the Dopamine Transporter in Parkinson's Disease
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco Addiction	Imaging smoking-induced dopamine release utilizing PET imaging and nicotine patches
Mental Health & Behavioral Research	Mechanistic Evaluation of Guanfacine on Drinking Behavior

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David Matuskey, MD

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