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Deepak Cyril Dsouza, MBBS, MD

Vikram Sodhi ’94 Professor of Psychiatry; Chair, Research and Development Committee; Director Schizophrenia Neuropharmacology Research Group at Yale (SNRGY); Director, Neurobiological Studies Unit, VACHS; Director, VA-CMHC Schizophrenia Research Clinic; Director, Yale Center for the Science of Cannabis and Cannabinoids

Contact Information

Deepak Cyril Dsouza, MBBS, MD

Mailing Address

  • Psychiatry

    950 Campbell Avenue

    West Haven, CT 06516

    United States

Research Summary

Our group has been studying the treatment and pathophysiology of serious mental illness and addictions. We conduct experimental studies in humans with various drugs (e.g., ketamine, delta-9-THC, iomazenil, DMT, etc) to probe the contributions of various neurotransmitter systems (NMDA, cannabinoid, GABA, etc) to the neurobiology of perception, cognition and reward processing relevant to psychosis, depression and addiction. We also use in vivo neuroreceptor imaging to study psychosis, depression and addiction with radioligands for synaptic proteins, M1 , CB1 receptors, etc. Lastly we are testing the safety and efficacy of new treatments for psychosis, depression and addiction.


Research Interests

Behavior and Behavior Mechanisms; Mental Disorders; Behavioral Disciplines and Activities; Psychological Phenomena; Psychiatry and Psychology

Selected Publications

Clinical Trials

ConditionsStudy Title
Mental Health & Behavioral ResearchM1 Schizophrenia PET Study
Diseases of the Nervous System; Mental Health & Behavioral ResearchTeen Brain and Behavior Study
Addictive Behaviors; Child Development & Autism; Mental Health & Behavioral ResearchA longitudinal study of the effects of cannabis exposure on neuro-development in adolescents and young adults
Mental Health & Behavioral ResearchPredictive Coding and Unusual Experiences
Diseases of the Nervous System; Mental Health & Behavioral ResearchExamination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral ResearchSleep Dependent Learning in Schizophrenia and Psychosis Risk Syndrome
Mental Health & Behavioral ResearchImaging mGluR5 and synaptic density in psychiatric disorders
Mental Health & Behavioral ResearchImaging SV2A in mood disorders
Addictive Behaviors; Diseases of the Nervous System; Genetics - Adult; Mental Health & Behavioral ResearchImaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning