Our group has been studying the treatment and pathophysiology of serious mental illness and addictions. We conduct experimental studies in humans with various drugs (e.g., ketamine, delta-9-THC, iomazenil, DMT, etc) to probe the contributions of various neurotransmitter systems (NMDA, cannabinoid, GABA, etc) to the neurobiology of perception, cognition and reward processing relevant to psychosis, depression and addiction. We also use in vivo neuroreceptor imaging to study psychosis, depression and addiction with radioligands for synaptic proteins, M1 , CB1 receptors, etc. Lastly we are testing the safety and efficacy of new treatments for psychosis, depression and addiction.
Behavior and Behavior Mechanisms; Mental Disorders; Behavioral Disciplines and Activities; Psychological Phenomena; Psychiatry and Psychology