Sule Tinaz, MD, PhD
Assistant Professor
Research & Publications
Biography
News
Locations
Research Summary
Most recent research activities include:
- Mental Imagery Study in Parkinson’s Disease (PI: Sule Tinaz)
- Imaging Biomarkers of Exercise-Induced Brain Changes in Parkinson's Disease (PIs: Sule Tinaz and Evan D. Morris)
- Dopamine Transporter Scan-Based Disease Progression Models for Early Parkinson’s Disease (PI: Hemant Tagare)
- Measuring synaptic density in Parkinson’s disease with SV2A PET imaging (PI: David Matuskey)
- Structural and functional brain changes in Wilson’s Disease (PI: Michael Schilsky)
Extensive Research Description
My lab investigates the brain changes in movement disorders, especially in Parkinson’s disease using imaging tools including magnetic resonance imaging, dopamine transporter scans, and positron emission tomography. We are particularly interested in investigating the brain plasticity changes in response to mental training and physical exercise in Parkinson’s disease.
Coauthors
Research Interests
Magnetic Resonance Imaging; Parkinson Disease; Neural Networks, Computer; Positron-Emission Tomography; Neuroimaging
Selected Publications
- Magnetic resonance imaging modalities aid in the differential diagnosis of atypical parkinsonian syndromesTinaz S. Magnetic resonance imaging modalities aid in the differential diagnosis of atypical parkinsonian syndromes Frontiers In Neurology 2023, 14: 1082060. PMID: 36816565, PMCID: PMC9932598, DOI: 10.3389/fneur.2023.1082060.
- Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanismsElfil M, Bayoumi A, Sayed A, Aladawi M, Aboutaleb P, Grieb L, Tolba H, Tinaz S. Stroke in Parkinson’s disease: a review of epidemiological studies and potential pathophysiological mechanisms Acta Neurologica Belgica 2023, 1-11. PMID: 36710306, DOI: 10.1007/s13760-023-02202-4.
- Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s diseaseCherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease Brain Imaging And Behavior 2022, 17: 1-11. PMID: 36434490, DOI: 10.1007/s11682-022-00749-z.
- Characterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory NetworkGuo X, Tinaz S, Dvornek N. Characterization of Early Stage Parkinson's Disease From Resting-State fMRI Data Using a Long Short-Term Memory Network Frontiers In Neuroimaging 2022, 1: 952084. DOI: 10.3389/fnimg.2022.952084.
- Parkinson's Disease Dementia and Lewy Body DiseaseSezgin M, Bilgic B, Tinaz S, Emre M. Parkinson's Disease Dementia and Lewy Body Disease Seminars In Neurology 2019, 39: 274-282. PMID: 30925619, DOI: 10.1055/s-0039-1678579.
- Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s DiseaseTinaz S, Para K, Vives-Rodriguez A, Martinez-Kaigi V, Nalamada K, Sezgin M, Scheinost D, Hampson M, Louis ED, Constable RT. Insula as the Interface Between Body Awareness and Movement: A Neurofeedback-Guided Kinesthetic Motor Imagery Study in Parkinson’s Disease Frontiers In Human Neuroscience 2018, 12: 496. PMID: 30581383, PMCID: PMC6292989, DOI: 10.3389/fnhum.2018.00496.
- Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson DiseaseTinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.
- Changes in functional organization and white matter integrity in the connectome in Parkinson's diseaseTinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.
- The Basal Ganglia and Decision-Making in Neuropsychiatric DisordersTinaz S, Stern C. The Basal Ganglia and Decision-Making in Neuropsychiatric Disorders 2016, 339-361. DOI: 10.1007/978-3-319-42743-0_15.
- Sequence Effect in Parkinson’s Disease Is Related to Motor Energetic CostTinaz S, Pillai AS, Hallett M. Sequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost Frontiers In Neurology 2016, 7: 83. PMID: 27252678, PMCID: PMC4877367, DOI: 10.3389/fneur.2016.00083.
- Role of the right dorsal anterior insula in the urge to tic in tourette syndromeTinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.
- Deficits in task-set maintenance and execution networks in Parkinson’s diseaseTinaz S, Lauro P, Hallett M, Horovitz SG. Deficits in task-set maintenance and execution networks in Parkinson’s disease Brain Structure And Function 2015, 221: 1413-1425. PMID: 25567420, PMCID: PMC5565229, DOI: 10.1007/s00429-014-0981-8.
- Role of the sensorimotor cortex in tourette syndrome using multimodal imagingTinaz S, Belluscio BA, Malone P, Veen J, Hallett M, Horovitz SG. Role of the sensorimotor cortex in tourette syndrome using multimodal imaging Human Brain Mapping 2014, 35: 5834-5846. PMID: 25044024, PMCID: PMC4776755, DOI: 10.1002/hbm.22588.
- Alcohol challenge and the sensitivity to change of the essential tremor rating assessment scale (TETRAS)Voller B, Lines E, McCrossin G, Artiles A, Tinaz S, Lungu C, Hallett M, Haubenberger D. Alcohol challenge and the sensitivity to change of the essential tremor rating assessment scale (TETRAS) Journal Of The Neurological Sciences 2013, 333: e77. DOI: 10.1016/j.jns.2013.07.545.
- On the functional anatomy of the urge-for-actionJackson S, Parkinson A, Kim S, Schüermann M, Eickhoff S, Proverbio A, Belluscio B, Tinaz S, Hallett M, Rivera-Rei Á, Canales-Johnson A, Huepe D, Ibáñez A, Nachev P, de Haan E, Ganos C, Hummel F, Rothwell J, Edwards M. On the functional anatomy of the urge-for-action Cognitive Neuroscience 2011, 2: 227-243. PMID: 22299020, PMCID: PMC3259619, DOI: 10.1080/17588928.2011.604717.
- Focal cortical and subcortical atrophy in early Parkinson's diseaseTinaz S, Courtney MG, Stern CE. Focal cortical and subcortical atrophy in early Parkinson's disease Movement Disorders 2010, 26: 436-441. PMID: 21462259, PMCID: PMC4502575, DOI: 10.1002/mds.23453.
- Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: An fMRI studyTinaz S, Schendan HE, Schon K, Stern CE. Evidence for the importance of basal ganglia output nuclei in semantic event sequencing: An fMRI study Brain Research 2005, 1067: 239-249. PMID: 16360121, DOI: 10.1016/j.brainres.2005.10.057.
Clinical Trials
Conditions | Study Title |
---|---|
Diseases of the Nervous System | Cognitive Training Study in Parkinson’s Disease |
Mental Health & Behavioral Research; Alzheimer's Disease | Ketamine for the Treatment of Depression in Parkinson's Disease |
Mental Health & Behavioral Research | Eligibility for Participation in Neuroimaging Studies |
Diseases of the Nervous System | Imaging the Dopamine Transporter in Parkinson's Disease |
Diseases of the Nervous System | Cognitive Training in Parkinson's Disease |