David Labaree, PhD
Associate Research Scientist in Radiology and Biomedical Imaging
Research & Publications
Biography
News
Coauthors
Selected Publications
- O-57 Synthesis and translational evaluation of three novel PARP PET tracers in nonhuman primates and rodent glioma brain tumor model with intact blood-brain barrierTong J, Takuya T, Thomas M, Chen M, Holden D, Kurpiewski S, Katz S, Chen B, Mennie W, Wenn M, Kapinos M, Zhang L, Felchner Z, Gao H, Labaree D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang H, Cai J. O-57 Synthesis and translational evaluation of three novel PARP PET tracers in nonhuman primates and rodent glioma brain tumor model with intact blood-brain barrier. Nuclear Medicine And Biology 2023, 126: 108453. DOI: 10.1016/j.nucmedbio.2023.108453.
- P-091 Target occupancy studies of rho-associated protein kinase inhibitors in nonhuman primate with [11C]ROCK201 PETZheng C, Gravel P, Mennie W, Holden D, Balayeva T, Kapinos M, Gao H, Ye Y, Wenn M, Fowles K, Ropchan J, Labaree D, Carson R, Huang H, Cai J. P-091 Target occupancy studies of rho-associated protein kinase inhibitors in nonhuman primate with [11C]ROCK201 PET. Nuclear Medicine And Biology 2023, 126: 108561. DOI: 10.1016/j.nucmedbio.2023.108561.
- P-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primatesTong J, Chen B, Gu J, Alluri S, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Carson R, Huang Y, Cai Z. P-304 The synthesis and bioevaluation of a novel and brain penetrable PARP1 tracer [18F]Pamiparib in rodents and nonhuman primates. Nuclear Medicine And Biology 2022, 108: s214-s215. DOI: 10.1016/s0969-8051(22)00440-1.
- P-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in miceTong J, Chen B, Alluri S, Gu J, Zheng M, Zheng C, Felchner Z, Gao H, Zhang L, Kapinos M, Labaree D, Ropchan J, Nabulsi N, Marquez-Nostra B, Carson R, Huang Y, Cai Z. P-303 Synthesis and preclinical evaluation of PD-L1 PET tracer [18F]FDHPA in mice. Nuclear Medicine And Biology 2022, 108: s214. DOI: 10.1016/s0969-8051(22)00439-5.
- Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activitiesZhang J, Labaree D, Hochberg R. Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities. Chinese Chemical Letters 2014, 25: 567-570. DOI: 10.1016/j.cclet.2014.01.015.
- ChemInform Abstract: Synthesis and Evaluation of 4‐(Substituted styryl/alkenyl)‐3,5‐bis(4‐hydroxyphenyl)‐isoxazoles as Ligands for the Estrogen Receptor.Haddad T, Gershman R, Dilis R, Labaree D, Hochberg R, Hanson R. ChemInform Abstract: Synthesis and Evaluation of 4‐(Substituted styryl/alkenyl)‐3,5‐bis(4‐hydroxyphenyl)‐isoxazoles as Ligands for the Estrogen Receptor. ChemInform 2013, 44: no-no. DOI: 10.1002/chin.201301119.
- ChemInform Abstract: Synthesis and Evaluation of 17α‐E‐20‐(Heteroaryl)norpregn‐1,3,5 (10),20‐tetraene‐3,17β‐diols [17α‐(Heteroaryl)vinyl Estradiols] as Ligands for the Estrogen Receptor‐α Ligand Binding Domain (ERα‐LBD).Olmsted S, Tongcharoensirikul P, McCaskill E, Gandiaga K, Labaree D, Hochberg R, Hanson R. ChemInform Abstract: Synthesis and Evaluation of 17α‐E‐20‐(Heteroaryl)norpregn‐1,3,5 (10),20‐tetraene‐3,17β‐diols [17α‐(Heteroaryl)vinyl Estradiols] as Ligands for the Estrogen Receptor‐α Ligand Binding Domain (ERα‐LBD). ChemInform 2012, 43: no-no. DOI: 10.1002/chin.201242199.
- Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptorHaddad T, Gershman R, Dilis R, Labaree D, Hochberg RB, Hanson RN. Synthesis and evaluation of 4-(substituted styryl/alkenyl)-3,5-bis(4-hydroxyphenyl)-isoxazoles as ligands for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters 2012, 22: 5999-6003. PMID: 22906893, PMCID: PMC3444814, DOI: 10.1016/j.bmcl.2012.06.097.
- Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonistsHanson RN, Hua E, Hendricks JA, Labaree D, Hochberg RB. Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists. Bioorganic & Medicinal Chemistry 2012, 20: 3768-3780. PMID: 22608920, PMCID: PMC3581310, DOI: 10.1016/j.bmc.2012.04.041.
- Targeting the estrogen receptor with metal-carbonyl derivatives of estradiolHanson RN, Kirss R, McCaskill E, Hua E, Tongcharoensirikul P, Olmsted SL, Labaree D, Hochberg RB. Targeting the estrogen receptor with metal-carbonyl derivatives of estradiol. Bioorganic & Medicinal Chemistry Letters 2012, 22: 1670-1673. PMID: 22277281, PMCID: PMC3274643, DOI: 10.1016/j.bmcl.2011.12.111.
- [11C]GR103545: novel one-pot radiosynthesis with high specific activityNabulsi NB, Zheng MQ, Ropchan J, Labaree D, Ding YS, Blumberg L, Huang Y. [11C]GR103545: novel one-pot radiosynthesis with high specific activity. Nuclear Medicine And Biology 2010, 38: 215-221. PMID: 21315277, DOI: 10.1016/j.nucmedbio.2010.08.014.
- Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PETCosgrove K, Gallezot J, Weinzimmer D, Fowles K, Labaree D, Zheng M, Lim K, Carson R, Morris E. Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PET. NeuroImage 2010, 52: s79. DOI: 10.1016/j.neuroimage.2010.04.063.
- Pharmacokinetic characterization of compounds with increased target residence times using PETSalinas C, Weinzimmer D, Searle G, Labaree D, Ding Y, Huang Y, Rabiner E, Carson R, Gunn R. Pharmacokinetic characterization of compounds with increased target residence times using PET. NeuroImage 2010, 52: s210-s211. DOI: 10.1016/j.neuroimage.2010.04.172.
- Imaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility studyHuang Y, Williams W, Tomasi G, Zheng M, Lin S, Ropchan J, Labaree D, Olsen J, Tabriz M, Planeta-Wilson B, Tauscher J, Ding Y, Carson R, Neumeister A. Imaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility study. NeuroImage 2010, 52: s199. DOI: 10.1016/j.neuroimage.2010.04.161.
- Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scannerGallezot J, Weinzimmer D, Fowles K, Labaree D, Cosgrove K, Ding Y, Morris E, Carson R. Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scanner. NeuroImage 2010, 52: s173. DOI: 10.1016/j.neuroimage.2010.04.141.
- A correction algorithm for carryover of tracer in paired C-11 studies: Application to the H-3 receptor antagonist [C-11]GSK189254Planeta-Wilson B, Labaree D, Gallezot J, Lin S, Nabulsi N, Williams W, McCarthy T, Ding Y, Huang Y, Carson R. A correction algorithm for carryover of tracer in paired C-11 studies: Application to the H-3 receptor antagonist [C-11]GSK189254. NeuroImage 2010, 52: s166. DOI: 10.1016/j.neuroimage.2010.04.135.
- Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: Test–retest reproducibility and gender differencesNormandin M, Zheng M, Ropchan J, Labaree D, Najafzadeh S, Hull R, Qian W, Henry S, Williams W, Carson R, Huang Y, Neumeister A. Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: Test–retest reproducibility and gender differences. NeuroImage 2010, 52: s82-s83. DOI: 10.1016/j.neuroimage.2010.04.066.
- Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humansNormandin M, Weinzimmer D, Ropchan J, Labaree D, Lin K, Mason N, Carson R, D'Souza D, Neumeister A, Huang Y. Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humans. NeuroImage 2010, 52: s13. DOI: 10.1016/j.neuroimage.2010.04.198.
- PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injuryHuang Y, Nabulsi N, Weinzimmer D, Fung E, Ropchan J, Labaree D, Wang X, Gould G, Frost J, Carson R, Strittmatter S. PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury. NeuroImage 2008, 41: t154. DOI: 10.1016/j.neuroimage.2008.04.122.
- First in human evaluation of [11C]AFM, a novel PET tracer for the serotonin transporterWilliams W, Neumeister A, Nabulsi N, Ropchan J, Labaree D, Planeta-Wilson B, Najafzadeh S, Carson R, Huang Y. First in human evaluation of [11C]AFM, a novel PET tracer for the serotonin transporter. NeuroImage 2008, 41: t42. DOI: 10.1016/j.neuroimage.2008.04.216.
- Quantification of serotonin transporters with [11C]AFM: Evaluation of reference region methodsNaganawa M, Planeta-Wilson B, Nabulsi N, Ropchan J, Labaree D, Neumeister A, Huang Y, Carson R. Quantification of serotonin transporters with [11C]AFM: Evaluation of reference region methods. NeuroImage 2008, 41: t28. DOI: 10.1016/j.neuroimage.2008.04.202.
- PET imaging of norepinephrine transporter in cocaine abuser using (S,S)-[11C]MRBSinghal T, Planeta-Wilson B, Gallezot J, Henry S, Nabulsi N, Labaree D, Ropchan J, Carson R, Neumeister A, Malison R, Ding Y. PET imaging of norepinephrine transporter in cocaine abuser using (S,S)-[11C]MRB. NeuroImage 2008, 41: t195. DOI: 10.1016/j.neuroimage.2008.04.162.
- Chemical fate of the estrogen receptor radiotracer [123I]-MIE2 in baboon plasmaBois F, Batis J, Labaree D, Amici L, Cosgrove K, Baldwin R, Hochberg R, Staley J. Chemical fate of the estrogen receptor radiotracer [123I]-MIE2 in baboon plasma. NeuroImage 2008, 41: t177. DOI: 10.1016/j.neuroimage.2008.04.144.
- Microwave‐Enhanced Nucleophilic Fluorination in the Synthesis of Fluoropyridyl Derivatives of [3,2‐c]Pyrazolo‐corticosteroids, Potential Glucocorticoid Receptor‐Mediated Imaging Agents.Kahn M, Konde E, Dossou F, Labaree D, Hochberg R, Hoyte R. Microwave‐Enhanced Nucleophilic Fluorination in the Synthesis of Fluoropyridyl Derivatives of [3,2‐c]Pyrazolo‐corticosteroids, Potential Glucocorticoid Receptor‐Mediated Imaging Agents. ChemInform 2006, 37: no-no. DOI: 10.1002/chin.200639207.
- Organometallic Complexes Containing 17-Ethynyl-17β-hydroxyandrost-4-en-3-one and Related Ethynyl SteroidsStockland R, Kohler M, Guzei I, Kastner M, Bawiec J, Labaree D, Hochberg R. Organometallic Complexes Containing 17-Ethynyl-17β-hydroxyandrost-4-en-3-one and Related Ethynyl Steroids. Organometallics 2006, 25: 2475-2485. DOI: 10.1021/om051064r.
- Estradiol-16α-carboxylic Acid Esters as Locally Active EstrogensLabaree D, Reynolds T, Hochberg R. Estradiol-16α-carboxylic Acid Esters as Locally Active Estrogens. Journal Of Medicinal Chemistry 2001, 44: 1802-1814. PMID: 11356114, DOI: 10.1021/jm000523h.
- [7α-18F]fluoro-17α-methyl-5α-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancerGarg P, Labaree D, Hoyte R, Hochberg R. [7α-18F]fluoro-17α-methyl-5α-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer. Nuclear Medicine And Biology 2001, 28: 85-90. PMID: 11182568, DOI: 10.1016/s0969-8051(00)00172-4.
- Regiospecific Esterification of Estrogens by Lecithin:Cholesterol AcyltransferaseKanji S, Kuohung W, Labaree D, Hochberg R. Regiospecific Esterification of Estrogens by Lecithin:Cholesterol Acyltransferase. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 2481-2488. PMID: 10404824, DOI: 10.1210/jcem.84.7.5755.
- 7α-Iodo and 7α-Fluoro Steroids as Androgen Receptor-Mediated Imaging AgentsLabaree D, Hoyte R, Nazareth L, Weigel N, Hochberg R. 7α-Iodo and 7α-Fluoro Steroids as Androgen Receptor-Mediated Imaging Agents. Journal Of Medicinal Chemistry 1999, 42: 2021-2034. PMID: 10354410, DOI: 10.1021/jm990064o.
- Iodinated and fluorinated steroid 2′-aryl-[3,2-c] pyrazoles as potential glucocorticoid receptor imaging agentsHoyte R, Labaree D, Fede J, Harris C, Hochberg R. Iodinated and fluorinated steroid 2′-aryl-[3,2-c] pyrazoles as potential glucocorticoid receptor imaging agents. Steroids 1998, 63: 595-602. PMID: 9830686, DOI: 10.1016/s0039-128x(98)00069-5.
- A direct stereoselective synthesis of 7β-hydroxytestosteroneLabaree D, Hoyte R, Hochberg R. A direct stereoselective synthesis of 7β-hydroxytestosterone. Steroids 1997, 62: 482-486. PMID: 9185296, DOI: 10.1016/s0039-128x(97)00018-4.