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INFORMATION FOR

John Krystal, MD

Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology; Co-Director, Yale Center for Clinical Investigation; Chair, Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD

Research Summary

Neurobiology; pharmacotherapy; genetics; neuroimaging; computational neuroscience

schizophrenia; alcoholism; PTSD; depression

Coauthors

Research Interests

Alcoholism; Drug Therapy; Genetics; Neurobiology; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans; Neuroimaging

Selected Publications

  • T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSDNunez D, Rompala G, Hurd Y, Nagamatsu S, Martínez-Magaña J, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSD European Neuropsychopharmacology 2022, 63: e205-e206. DOI: 10.1016/j.euroneuro.2022.07.369.
  • Post-traumatic Stress DisorderMerians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder Medical Clinics Of North America 2022 DOI: 10.1016/j.mcna.2022.04.003.
  • Illness Phase as a Key Assessment and Intervention Window for PsychosisKohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Gur R, Gur R, Calkins M, D'Souza D, Srihari V, Gueorguieva R, Gueorguieva R, Patel P, Forselius-Bielen K, Forselius-Bielen K, Lu J, Butler A, Fram G, Fram G, Afriyie-Agyemang Y, Selloni A, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Abrahim P, Nia A, Nia A, Surti T, Surti T, Kegeles L, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Benedict E, Govil P, Govil P, Brazis S, Mayer M, Garrigue N, Fallon N, Fallon N, Baumvoll T, Abeykoon S, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T. Illness Phase as a Key Assessment and Intervention Window for Psychosis Biological Psychiatry Global Open Science 2022 DOI: 10.1016/j.bpsgos.2022.05.009.
  • P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical NeuronsNunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
  • P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military VeteransNagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
  • P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSDHillmer A, Davis M, Esterlis I, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSD Biological Psychiatry 2022, 91: s351. DOI: 10.1016/j.biopsych.2022.02.883.
  • A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMCID: PMC9669946, DOI: 10.1159/000524079.
  • Edward F. Domino, Ph.D. (1924–2021)Krystal J. Edward F. Domino, Ph.D. (1924–2021) Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
  • Feasibility Analysis of Phenotype Quantification from Unstructured Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions Computational Psychiatry 2022, 6: 1. DOI: 10.5334/cpsy.78.
  • 14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEXRompala G, Nagamatsu S, Hurd Y, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. 14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEX European Neuropsychopharmacology 2021, 51: e47-e48. DOI: 10.1016/j.euroneuro.2021.07.106.
  • The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysisBeck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
  • Imaging the Effect of Ketamine on Synaptic (SV2A) DensityHolmes S, Finnema S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Angarita G, Duman R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
  • Preliminary Evaluation of Phenotypic Features from Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
  • Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and RiskGirgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
  • P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationshipsMoujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
  • A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive DisorderNemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
  • Preliminary Phenotypic Feature Capture During Clinical InteractionBarron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
  • What Can Machine Learning Do for Psychiatry?Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
  • Transcriptomic Organization of Human Posttraumatic Stress DisorderGirgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
  • Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and DiseaseWendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
  • Ronald S. Duman (1954–2020)Nestler E, Krystal J. Ronald S. Duman (1954–2020) Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
  • Ronald S. Duman, Ph.D. (1954–2020)Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020) Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
  • S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With SchizophreniaMoujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
  • S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain ModulationBurt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
  • 142. Synaptic Density Alterations are Associated With Depression Severity and Network AlterationsHolmes S, Scheinost D, Finnema S, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Angarita G, Pietrzak R, Duman R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations Biological Psychiatry 2019, 85: s59. DOI: 10.1016/j.biopsych.2019.03.156.
  • F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional ConnectivityMoujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
  • T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working MemoryCho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
  • S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional ConnectivityBarron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
  • 26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. VeteransMontalvo-Ortiz J, Gelernter J, Southwick S, Krystal J, Pietrzak R. 26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. Veterans Biological Psychiatry 2019, 85: s11. DOI: 10.1016/j.biopsych.2019.03.040.
  • T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for SchizophreniaHamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
  • T174. Examining the Neurobiological Progression of Early Course SchizophreniaKolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
  • S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning ModelKaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
  • Erratum to: Ketamine: A Promising Rapid-Acting AntidepressantWilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
  • F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSDHillmer A, Esterlis I, Davis M, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSD Biological Psychiatry 2018, 83: s237-s238. DOI: 10.1016/j.biopsych.2018.02.616.
  • S232. Effects of Incentive Presentation on Spatial Working Memory PerformanceCho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
  • F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major DepressionZhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
  • T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal CortexGirgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
  • 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVEKrystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
  • Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational NeuroscienceAnticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
  • Ketamine: A Promising Rapid-Acting AntidepressantWilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
  • 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A ReceptorPreller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
  • 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress DisorderDavis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
  • 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging StudyEsterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
  • 399 Ketamine and Guanfacine Effects on Activation and Connectivity during Working Memory: A Functional Magnetic Resonance Imaging InvestigationDriesen N, McCarthy G, Arnsten A, Morgan P, He G, Bloch M, Krystal J. 399 Ketamine and Guanfacine Effects on Activation and Connectivity during Working Memory: A Functional Magnetic Resonance Imaging Investigation Biological Psychiatry 2017, 81: s163. DOI: 10.1016/j.biopsych.2017.02.416.
  • 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional ConnectivityAnticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
  • 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like SymptomsCortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
  • 961 Incentives to Perform: The Effects of Reward on Working MemoryCho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
  • 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch NegativityHamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
  • 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal ApproachAkiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
  • 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma OscillationsFerri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
  • 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC ConsortiaMorey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
  • Speaker 3: John Krystal, USAKrystal J, Anticevic A, Yang G, Driesen N, Cortes-Briones J, Stone J, Wang X, Murray J. Speaker 3: John Krystal, USA The International Journal Of Neuropsychopharmacology 2016, 19: 5-5. PMCID: PMC5616483, DOI: 10.1093/ijnp/pyw042.007.
  • Speaker 4: John Krystal, USAKrystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
  • KetamineAbdallah C, Krystal J. Ketamine 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
  • Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and MiceBaldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
  • KetamineAbdallah C, Krystal J. Ketamine 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
  • 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIAAnticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
  • Pl.2 - KETAMINEKrystal J. Pl.2 - KETAMINE Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
  • Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficitsAnticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
  • P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generationStone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
  • Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1qZuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
  • Biological Psychiatry: A Time of Opportunity, a Time of ChallengeKrystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
  • P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency departmentLarkin G, Beautrais A, Turelli R, Sanacora G, Powsner S, Lippmann M, Krystal J. P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department European Psychiatry 2011, 26: 1607. DOI: 10.1016/s0924-9338(11)73311-9.
  • Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol DependenceKrystal J, Petrakis I, Limoncelli D, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
  • Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of SchizophreniaKrystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
  • 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency DepartmentLarkin G, Beautrais A, Powsner S, Sanacora G, Krystal J, Turelli R, Lippmann M. 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency Department Annals Of Emergency Medicine 2010, 56: s53. DOI: 10.1016/j.annemergmed.2010.06.204.
  • Neurotransmitter Systems in Bipolar DisorderNakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
  • In ReplySen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
  • IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIACavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
  • NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in HumansDriesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
  • Biological Psychiatry: Real ProgressKrystal J. Biological Psychiatry: Real Progress Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
  • Serotonin-1B receptor imaging in PTSDNeumeister A, Neumeister A, Czermak C, Czermak C, Henry S, Planeta-Wilson B, Planeta-Wilson B, Huang H, Huang H, Ding Y, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
  • Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkersEsterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
  • New probes for imaging dopamine transmission in at risk subjects for alcoholismUrban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
  • The Neuroscience Research Program at the Connecticut Mental Health CenterHeninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
  • Biological Psychiatry: Increasing ImpactKrystal J. Biological Psychiatry: Increasing Impact Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
  • ReplyKaufman J, Massey J, Krystal J, Gelernter J. Reply Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
  • Neurobiology and Treatment of DepressionNeumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression 2007 DOI: 10.1002/9780470101001.hcn018.
  • Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and DiazepamKrupitsky E, Rudenko A, Burakov A, Slavina T, Grinenko A, Pittman B, Gueorguieva R, Petrakis I, Zvartau E, Krystal J. Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and Diazepam Alcoholism Clinical And Experimental Research 2007, 0: 070212174136008-???. DOI: 10.1111/j.1530-0277.2007.00344.x.
  • Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-ArPittman B, Gueorguieva R, Krupitsky E, Rudenko A, Flannery B, Krystal J. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar Alcoholism Clinical And Experimental Research 2007, 0: 070212174136010-???. DOI: 10.1111/j.1530-0277.2007.00345.x.
  • Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative StudyGelernter J, Gueorguieva R, Kranzler H, Zhang H, Cramer J, Rosenheck R, Krystal J. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study Alcoholism Clinical And Experimental Research 2007, 0: 070212174136005-???. DOI: 10.1111/j.1530-0277.2007.00339.x.
  • Psychoactive DrugsD'Souza D, Krystal J. Psychoactive Drugs 2006 DOI: 10.1002/0470018860.s00599.
  • [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokersStaley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
  • Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or DependencePerry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
  • P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol cravingTsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
  • Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophreniaHoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
  • ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE.Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcoholism Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
  • HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT.Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcoholism Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
  • Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophreniaPetrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
  • Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophreniaD'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
  • Blood dyscrasiasCho H, Krystal J, D’Souza D. Blood dyscrasias 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
  • Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorderQin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
  • S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSDRasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
  • S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosisKrystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
  • Impact of nicotine on brain function in smokers with schizophreniaJacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
  • One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinationsHoffman R, Hawkins K, Anderson A, Buchanan R, Wu K, Hampson M, Gueorguieva R, Carroll K, Spencer D, Krystal J. One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinations Schizophrenia Research 2003, 60: 285-286. DOI: 10.1016/s0920-9964(03)80467-x.
  • Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humansD'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
  • Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and TreatmentKrystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
  • Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissãoMason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
  • Comorbidity of psychiatric and substance abuse disordersGeorge T, Krystal J. Comorbidity of psychiatric and substance abuse disorders Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
  • 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinationsHoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
  • 304. Cortical GABA reduced in unipolar but not bipolar depressionMason G, Sanacora G, Anand A, Anand A, Epperson C, Goddard A, Goddard A, Rothman D, Charney D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00568-0.
  • 305. Reduced cortical GABA in depression is not due to decreased gray matterSanacora G, Mason G, Rothman D, Epperson C, Goddard A, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00569-2.
  • 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis studyAbi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
  • 203. Working memory: constructs, neural circuits, and pharmacological modulationBelger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
  • 455. Sensory gating in older healthy adultsBoutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
  • Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate releaseAnand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
  • Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactionsKrystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
  • Dose-response of acute ethanol administration in schizophrenic patients and controlsD'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
  • Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controlsD'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
  • The Emerging Neurobiology of Dissociative StatesKrystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
  • Therapeutic Implications of the Hyperglutamatergic Effects of NMDA AntagonistsKrystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
  • Nimodipine attenuates psychotigenic effects of ketamine in humansKrupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
  • NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disordersKrystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
  • CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy ControlsPetrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls Alcoholism Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
  • Applications of Magnetic Resonance Spectroscopy to PsychiatrySanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
  • 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRSSanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
  • 24. Quantification of cortical GABA levels in neuropsychiatric patientsSanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients Biological Psychiatry 1998, 43: s8. DOI: 10.1016/s0006-3223(98)90472-3.
  • 435. Dose-response of THC effects in schizophrenics and healthy controlsD'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
  • 204. Glutamate, dopamine, the frontal cortex, and schizophreniaKrystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
  • Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI studyBelger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
  • Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress DisorderKrystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
  • Benzodiazepine Receptor AntagonistsAbi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
  • 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopyBehar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
  • 617 Dose-related ethanol effects in schizophrenic patientsZuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
  • 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controlsD’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
  • 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophreniaBelger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
  • 357 Behavioral dissociation of working memory and selective attention functions in schizophreniaBelger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
  • 601 Glycine ketamine interactions in healthy humansD’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
  • 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophreniaZuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
  • 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patientsLaruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
  • AMPT Effects on Cue‐Induced Craving for CocainePetrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
  • O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophreniaD’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
  • 208. Increased striatal dopamine release in drug free schizophrenic subjectsLaruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
  • 326. GABA-serotonin interactions in healthy subjects: Implications for psychosisGil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
  • Dose response of oral D-cycloserine in unmedicated and medicated schizophrenicsD'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
  • AMPT Effects on Cue-Induced Craving for CocainePetrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
  • Recent Developments in the Neurobiology of DissociationKrystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
  • Functional neuroanatomical correlates of the effects of stress on memoryBremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
  • Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamineKrystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
  • Evaluation of frontal and parietal association cortex contributions to attention using fMRIBelger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
  • The effect of ketamine on pre-pulse inhibition and attentionKarper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
  • Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophreniaD'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
  • Neurobiology of Post-Traumatic Stress DisorderSouthwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
  • Relationship of Panic Disorder to Posttraumatic Stress Disorder-ReplySouthwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
  • ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERSKarper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
  • I.V. glycine/d-cycloserine to facilitate NMDA function in humansD'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
  • Soft signs, attention, and startle in schizophreniaKarper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
  • Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-ReplyKrystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
  • Perturbing the Organism: The Biology of Stressful ExperienceD'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
  • Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenilAbi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
  • The neurological evaluation scale (NES): Factor analysis and clinical correlatesKarper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
  • Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjectsKarper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
  • Alexithymia as a predictor of treatment response in post-traumatic stress disorderKosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
  • Alexithymia as a predictor of treatment response in post‐traumatic stress disorderKosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
  • Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder.WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
  • Follow-up Study of Patients With Panic Disorder-ReplyNagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
  • MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatmentKrystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
  • Elevated central levels of interleukin-2 in drug-free schizophrenic patientsLicinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
  • Neurobiological Mechanisms of Human AnxietyCharney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety 1990, 3: 242-283. DOI: 10.1159/000417680.
  • Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-ReplyPrice L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
  • EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTSWoods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
  • Neurobiological aspects of PTSD: Review of clinical and preclinical studiesKrystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
  • Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance AbuseKosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse 1988, 49-68. DOI: 10.1007/978-1-4615-7718-8_3.
  • Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11 The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.

Clinical Trials

ConditionsStudy Title
Addictive Behaviors; Alcohol Addiction; Mental Health & Behavioral ResearchAlcohol Interaction Study
Mental Health & Behavioral ResearchA Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
Mental Health & Behavioral ResearchEfficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
Diseases of the Nervous System; Mental Health & Behavioral ResearchTeen Brain and Behavior Study
Diseases of the Nervous System; Mental Health & Behavioral ResearchExamination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral ResearchAlpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Mental Health & Behavioral ResearchMavoglurant in Alcohol Drinking
Diseases of the Nervous System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchBrain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Mental Health & Behavioral ResearchImaging mGluR5 and synaptic density in psychiatric disorders
Diseases of the Nervous System; Mental Health & Behavioral ResearchBiomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
Mental Health & Behavioral Research; COVID-19 Inpatient; COVID-19 OutpatientHave you had COVID-19?