John Krystal, MD

• Adife Gulhan Ercan-Sencicek
• Alan Anticevic
• Albert Powers
• Alex Kwan
• Amy Arnsten
• Angela Cappiello
• Ansel Hillmer
• Arie Kaffman
• Barbara Gulanski
• Benjamin Bunney
• Brenda Cabrera-Mendoza
• Brian Pittman
• Carolyn M Mazure
• Chadi Abdallah
• Charles Gordon
• Chiang-Shan Ray Li
• Christopher Pittenger
• Christopher van Dyck
• D. S. Fahmeed Hyder
• Daeyeol Lee
• Dan Oren
• Daniel F. Levey
• David Matuskey
• Deepak Cyril Dsouza
• Dolores Vojvoda
• Douglas Rothman
• Dustin Scheinost
• Edward Perry
• Eli Neustadter
• Elizabeth Roessler
• Eyiyemisi Damisah
• Geena Fram
• George Anderson
• Gerard Sanacora
• Gilles Tamagnan
• Gita Pathak
• Godfrey Pearlson
• Graeme Mason
• Guido Falcone
• Hang Zhou
• Herta Chao
• Hongyu Zhao
• Ifat Levy
• Ilan Harpaz-Rotem
• Irina Esterlis
• Ismene Petrakis
• Jacob Tebes
• Jaime Ide
• Jane Rebecca Taylor
• Janitza Montalvo-Ortiz
• Jason Johannesen
• Jean-Dominique Gallezot
• Jeanette Tetrault
• Jennifer Kapo
• Jiawei Wang
• Joel Gelernter
• John D Murray
• José Jaime Martínez-Magaña
• Julia Shi
• Keith Hawkins
• Kelly Cosgrove
• Kelly S. DeMartini
• Keyrun Adhikari
• Kimberly Yonkers
• Kristine Olson
• Kun Wu
• Linda Mayes
• Lingeng Lu
• Louis Trevisan
• Lynnette A. Averill
• Maggie Taylor Davis
• Maolin Qiu
• Marc Rosen
• Margaret Altemus
• Marina Picciotto
• Mario Skarica
• Matthew Girgenti
• Michael Bloch
• Michael Crowley
• Michael Kapinos
• Michael McClurkin
• Michael Sernyak
• Mika Naganawa
• Morris Bell
• Nabeel Nabulsi
• Nachshon Korem
• Nallakkandi Rajeevan
• Naomi Driesen
• Ned Cooney
• Nicole DellaGioia
• Or Duek
• Patrick G. O'Connor
• Peter Herman
• Peter Jongho Na
• Peter Morgan
• Philip Corlett
• Rachel Katz
• Rajiv Radhakrishnan
• Ralitza Gueorguieva
• Renato Polimanti
• Richard Carson
• Richard Formica
• Robert Chow
• Robert Ostroff
• Robert Pietrzak
• Robert Rosenheck
• Samuel Wilkinson
• Sarah Fineberg
• Seth Powsner
• Sheila Nagamatsu
• Shelley Amen
• Shivani Bhatt
• Sophie E Holmes
• Summer L Thompson
• Susan Nappi
• Todd Constable
• Toral Surti
• Vinod Srihari
• Xingguang Luo
• Zailyn Tamayo
• Zubin Bhagwagar

Alcoholism; Drug Therapy; Genetics; Neurobiology; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans; Neuroimaging

• Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAgeTamman A, Koller D, Nagamastu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 1-10. PMID: 37848731, DOI: 10.1038/s41386-023-01747-5.
• Psychedelics and the neurobiology of meaningfulnessKrystal J, Preller K, Corlett P, Anticevic A, Kaye A. Psychedelics and the neurobiology of meaningfulness. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023 PMID: 37730161, DOI: 10.1016/j.bpsc.2023.09.003.
• Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Na P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 1-9. PMID: 37642191, DOI: 10.1017/s003329172300199x.
• Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortexRompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
• Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanismsKrystal J, Kavalali E, Monteggia L. Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms. Neuropsychopharmacology 2023, 1-10. PMID: 37488280, DOI: 10.1038/s41386-023-01629-w.
• DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress DisorderBenfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37410416, DOI: 10.1037/tra0001537.
• Long term structural and functional neural changes following a single infusion of Ketamine in PTSDDuek O, Korem N, Li Y, Kelmendi B, Amen S, Gordon C, Milne M, Krystal J, Levy I, Harpaz-Rotem I. Long term structural and functional neural changes following a single infusion of Ketamine in PTSD. Neuropsychopharmacology 2023, 48: 1648-1658. PMID: 37270621, PMCID: PMC10517133, DOI: 10.1038/s41386-023-01606-3.
• Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 PandemicFischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.
• A computational model for learning from repeated traumatic experiences under uncertaintyKaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, DOI: 10.3758/s13415-023-01085-5.
• Candidate biomarkers in psychiatric disorders: state of the fieldAbi-Dargham A, Moeller S, Ali F, DeLorenzo C, Domschke K, Horga G, Jutla A, Kotov R, Paulus M, Rubio J, Sanacora G, Veenstra-VanderWeele J, Krystal J. Candidate biomarkers in psychiatric disorders: state of the field. World Psychiatry 2023, 22: 236-262. PMID: 37159365, PMCID: PMC10168176, DOI: 10.1002/wps.21078.
• Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophreniaSurti T, Ranganathan M, Johannesen J, Gueorguieva R, Deaso E, Kenney J, Krystal J, D'Souza D. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research 2023, 256: 36-43. PMID: 37141764, PMCID: PMC10257994, DOI: 10.1016/j.schres.2023.04.010.
• 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive DisorderSarantopoulos C, Shin D, Schleifer C, Moujaes F, Adkinson B, Ji J, Kolabaric A, Flynn M, Santamauro N, Krystal J, Murray J, Repovs G, Martin W, Pittenger C, Anticevic A, Cho Y. 511. Common and Distinct Effects of Incentives on Spatial Working Memory in Schizophrenia and Obsessive-Compulsive Disorder. Biological Psychiatry 2023, 93: s300-s301. DOI: 10.1016/j.biopsych.2023.02.751.
• CpG and Non-CpG Epigenomic Analyses in Orbitofrontal Neurons Reveal Hydroxymethylation as an Important Regulatory Mechanism in PTSDMontalvo-Ortiz J, Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martínez-Magaña J, Krystal J. CpG and Non-CpG Epigenomic Analyses in Orbitofrontal Neurons Reveal Hydroxymethylation as an Important Regulatory Mechanism in PTSD. Biological Psychiatry 2023, 93: s68. DOI: 10.1016/j.biopsych.2023.02.183.
• 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the CortexDriesen N, Herman P, Rowland M, Thompson G, Qiu M, He G, Criscuolo E, Fineberg S, Barron D, Helgeson L, Lacadie C, Chow R, Gueorguieva R, Straun T, Krystal J, Hyder F. 430. Calibrated fMRI Sensitive to Ketamine-Related Increases Throughout the Cortex. Biological Psychiatry 2023, 93: s268-s269. DOI: 10.1016/j.biopsych.2023.02.670.
• 248. Effects of NMDA Receptor Antagonist Ketamine on Neural TuningRahmati M, Moujaes F, Schleifer C, Ji J, Fonteneau C, Tamayo Z, Santamauro N, Respov G, Fineberg S, Krystal J, Murray J, Cho Y, Anticevic A. 248. Effects of NMDA Receptor Antagonist Ketamine on Neural Tuning. Biological Psychiatry 2023, 93: s193-s194. DOI: 10.1016/j.biopsych.2023.02.488.
• Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal CortexGirgenti M, Zhang J, Skarica M, Hwang A, Xu K, Young K, Zhao H, Sestan N, Krystal J. Single Cell Genomic Analysis Reveals Cell Type-Specific Molecular Signatures in the Human PTSD Prefrontal Cortex. Biological Psychiatry 2023, 93: s11-s12. DOI: 10.1016/j.biopsych.2023.02.049.
• Functional brain networks reflect spatial and temporal autocorrelationShinn M, Hu A, Turner L, Noble S, Preller K, Ji J, Moujaes F, Achard S, Scheinost D, Constable R, Krystal J, Vollenweider F, Lee D, Anticevic A, Bullmore E, Murray J. Functional brain networks reflect spatial and temporal autocorrelation. Nature Neuroscience 2023, 26: 867-878. PMID: 37095399, DOI: 10.1038/s41593-023-01299-3.
• 93 Empowering the Next Generation of Clinical & Translational ScientistsJohnson T, Davis J, Smith B, Krystal J, Sevier B, Perry L, Clayton E, Black S. 93 Empowering the Next Generation of Clinical & Translational Scientists. Journal Of Clinical And Translational Science 2023, 7: 26-26. PMCID: PMC10129482, DOI: 10.1017/cts.2023.176.
• 183 Explaining Research to Children and AdolescentsJohnson T, Black S, Smith B, Krystal J, Sevier B, Aly F, Kumpf B, Grover K, Solod A. 183 Explaining Research to Children and Adolescents. Journal Of Clinical And Translational Science 2023, 7: 56-57. PMCID: PMC10129822, DOI: 10.1017/cts.2023.261.
• Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse WorkforceWidge A, Jordan A, Kraguljac N, Sullivan C, Wilson S, Benton T, Alpert J, Carpenter L, Krystal J, Nemeroff C, Dzirasa K. Structural Racism in Psychiatric Research Careers: Eradicating Barriers to a More Diverse Workforce. American Journal Of Psychiatry 2023, 180: 645-659. PMID: 37073513, DOI: 10.1176/appi.ajp.20220685.
• Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial ProgramWunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and Safety of Iclepertin (BI 425809) in Patients With Schizophrenia: CONNEX, A Phase III Randomized Controlled Trial Program. CNS Spectrums 2023, 28: 229-229. DOI: 10.1017/s1092852923001530.
• Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020Havlik J, Murphy M, Gong N, Tang D, Krystal J. Characteristics of Esketamine Prescribers Among Medicare Beneficiaries in the United States, 2019-2020. JAMA Network Open 2023, 6: e2311250. PMID: 37103934, PMCID: PMC10140803, DOI: 10.1001/jamanetworkopen.2023.11250.
• Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approachJia R, Ruderman L, Pietrzak R, Gordon C, Ehrlich D, Horvath M, Mirchandani S, DeFontes C, Southwick S, Krystal J, Harpaz-Rotem I, Levy I. Neural valuation of rewards and punishments in posttraumatic stress disorder: a computational approach. Translational Psychiatry 2023, 13: 101. PMID: 36977676, PMCID: PMC10050320, DOI: 10.1038/s41398-023-02388-4.
• Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal studyNa P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, DOI: 10.1016/j.drugalcdep.2023.109833.
• A pilot randomized controlled trial of ketamine in Borderline Personality DisorderFineberg S, Choi E, Shapiro-Thompson R, Dhaliwal K, Neustadter E, Sakheim M, Null K, Trujillo-Diaz D, Rondeau J, Pittaro G, Peters J, Corlett P, Krystal J. A pilot randomized controlled trial of ketamine in Borderline Personality Disorder. Neuropsychopharmacology 2023, 48: 991-999. PMID: 36804489, PMCID: PMC10209175, DOI: 10.1038/s41386-023-01540-4.
• Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic ReviewNúñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 100-118. DOI: 10.1159/000529536.
• Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review.Núñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
• Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 PandemicFischer I, Na P, Harpaz-Rotem I, Krystal J, Pietrzak R. Characterization of Mental Health in US Veterans Before, During, and 2 Years After the Onset of the COVID-19 Pandemic. JAMA Network Open 2023, 6: e230463. PMID: 36821116, PMCID: PMC9951035, DOI: 10.1001/jamanetworkopen.2023.0463.
• CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorderNagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
• Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and VeteransStanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
• Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trialKrystal J, Kane J, Correll C, Walling D, Leoni M, Duvvuri S, Patel S, Chang I, Iredale P, Frohlich L, Versavel S, Perry P, Sanchez R, Renger J. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. The Lancet 2022, 400: 2210-2220. PMID: 36528376, DOI: 10.1016/s0140-6736(22)01990-0.
• Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohortNagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
• Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burdenNichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 53: 6325-6333. PMID: 36444557, DOI: 10.1017/s0033291722003646.
• Post-traumatic Stress DisorderMerians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.
• T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSDNunez D, Rompala G, Hurd Y, Nagamatsu S, Martínez-Magaña J, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSD. European Neuropsychopharmacology 2022, 63: e205-e206. DOI: 10.1016/j.euroneuro.2022.07.369.
• Post-traumatic Stress DisorderMerians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022 DOI: 10.1016/j.mcna.2022.04.003.
• Illness Phase as a Key Assessment and Intervention Window for PsychosisKohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.
• Illness Phase as a Key Assessment and Intervention Window for PsychosisKohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Gur R, Group T, Gur R, D'Souza D, Calkins M, Srihari V, Gueorguieva R, D'Souza D, Patel P, Srihari V, Forselius-Bielen K, Gueorguieva R, Lu J, Patel P, Butler A, Forselius-Bielen K, Fram G, Lu J, Afriyie-Agyemang Y, Butler A, Fram G, Selloni A, Cadavid L, Afriyie-Agyemang Y, Selloni A, Gomez-Luna S, Gupta A, Cadavid L, Radhakrishnan R, Gomez-Luna S, Rashid A, Gupta A, Aker R, Radhakrishnan R, Abrahim P, Rashid A, Nia A, Aker R, Surti T, Abrahim P, Nia A, Kegeles L, Carlson M, Surti T, Goldberg T, Kegeles L, Gangwisch J, Carlson M, Benedict E, Goldberg T, Govil P, Gangwisch J, Brazis S, Benedict E, Mayer M, Govil P, de la Garrigue N, Brazis S, Fallon N, Mayer M, Baumvoll T, Garrigue N, Abeykoon S, Fallon N, Perlman G, Baumvoll T, Bobchin K, Abeykoon S, Elliott M, Perlman G, Schmidt L, Bobchin K, Rush S, Elliott M, Port A, Schmidt L, Heffernan Z, Rush S, Laney N, Port A, Kantor J, Heffernan Z, Hohing T, Laney N, Gur R, Kantor J, Gur R, Hohing T, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022 DOI: 10.1016/j.bpsgos.2022.05.009.
• P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical NeuronsNunez-Rios D, Rompala G, Hurd Y, Nagamatsu S, Martinez-Magaña J, Krystal J, Gelernter J, Montalvo-Ortiz T. P630. Multiomics Mapping of Posttraumatic Stress Disorder in Human Cortical Neurons. Biological Psychiatry 2022, 91: s344. DOI: 10.1016/j.biopsych.2022.02.867.
• P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military VeteransNagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
• P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSDHillmer A, Davis M, Esterlis I, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSD. Biological Psychiatry 2022, 91: s351. DOI: 10.1016/j.biopsych.2022.02.883.
• P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in AnxietyAljishi A, Sandhu M, Shaikh N, Wise T, Krystal J, Kaye A, Damisah E. P143. Intracranial Electrophysiology of Amygdala-Insula Interactions in Anxiety. Biological Psychiatry 2022, 91: s144-s145. DOI: 10.1016/j.biopsych.2022.02.377.
• P142. Neural Correlates of Bodily Feedback During Spatial Threat AvoidanceShaikh N, Sandhu M, Aljishi A, Obaid S, Gu B, Krystal J, Kaye A, Damisah E. P142. Neural Correlates of Bodily Feedback During Spatial Threat Avoidance. Biological Psychiatry 2022, 91: s144. DOI: 10.1016/j.biopsych.2022.02.376.
• Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depressionSwanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
• A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMCID: PMC9669946, DOI: 10.1159/000524079.
• A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
• Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
• Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veteransMontalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
• Edward F. Domino, Ph.D. (1924–2021)Krystal J. Edward F. Domino, Ph.D. (1924–2021). Neuropsychopharmacology 2022, 47: 1138-1139. PMCID: PMC8938419, DOI: 10.1038/s41386-022-01280-x.
• Feasibility Analysis of Phenotype Quantification from Unstructured Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Birnbaum M, Constable T, Cecchi G, Krystal J. Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions. Computational Psychiatry 2022, 6: 1. DOI: 10.5334/cpsy.78.
• Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programmeWunderlich G, Blahova Z, Hake S, Ikezawa S, Marder S, Falkai P, Krystal J. Efficacy and safety of BI 425809 in patients with schizophrenia: CONNEX, a Phase III randomised controlled trial programme. Neuroscience Applied 2022, 1: 100342. DOI: 10.1016/j.nsa.2022.100342.
• Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veteransNa PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans. Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
• Potential Schizophrenia Medications Point to New Disease ModelKrystal J. Potential Schizophrenia Medications Point to New Disease Model. Psychiatric News 2021, 56 DOI: 10.1176/appi.pn.2021.11.37.
• 14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEXRompala G, Nagamatsu S, Hurd Y, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. 14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEX. European Neuropsychopharmacology 2021, 51: e47-e48. DOI: 10.1016/j.euroneuro.2021.07.106.
• Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human ParticipantsThompson SL, Gianessi CA, O'Malley SS, Cavallo DA, Shi JM, Tetrault JM, DeMartini KS, Gueorguieva R, Pittman B, Krystal JH, Taylor JR, Krishnan-Sarin S. Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants. Frontiers In Psychiatry 2021, 12: 709559. PMID: 34531767, PMCID: PMC8438169, DOI: 10.3389/fpsyt.2021.709559.
• The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysisBeck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza D, Taylor M, Krystal J, Howes O. The effect of ketamine on psychopathology and implications for understanding schizophrenia and its therapeutic use: a meta-analysis. BJPsych Open 2021, 7: s237-s237. PMCID: PMC8771247, DOI: 10.1192/bjo.2021.634.
• Imaging the Effect of Ketamine on Synaptic (SV2A) DensityHolmes S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density. Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
• Preliminary Evaluation of Phenotypic Features from Clinical InteractionsBarron D, Heisig S, Agurto C, Norel R, Quagan B, Powers A, Baker J, Constable T, Cecchi G, Krystal J. Preliminary Evaluation of Phenotypic Features from Clinical Interactions. Journal Of Pain 2021, 22: 594. DOI: 10.1016/j.jpain.2021.03.068.
• Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and RiskGirgenti M, Skarica M, Zhang J, Wang J, Friedman M, Zhao H, Krystal J. Integrative Functional Genomic Analysis of Human PTSD Molecular Pathology and Risk. Biological Psychiatry 2021, 89: s12. DOI: 10.1016/j.biopsych.2021.02.050.
• Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal CortexMcClurkin M, Krystal J, Kaye A, Damisah E. Human iEEG Characterization of Threat and Anxiety Oscillations Across Amygdala, Hippocampus, and Frontal Cortex. Biological Psychiatry 2021, 89: s255. DOI: 10.1016/j.biopsych.2021.02.638.
• Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
• Transcriptomic organization of the human brain in post-traumatic stress disorderGirgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder. Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
• Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experienceKrystal JH, Alvarado J, Ball SA, Fortunati FG, Hu M, Ivy ME, Kapo J, Olson KD, Rohrbaugh RM, Sinha R, Tebes JK, Vender RJ, Yonkers KA, Mayes LC. Mobilizing an institutional supportive response for healthcare workers and other staff in the context of COVID-19: The Yale experience. General Hospital Psychiatry 2020, 68: 12-18. PMID: 33254081, PMCID: PMC7680059, DOI: 10.1016/j.genhosppsych.2020.11.005.
• P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationshipsMoujaes F, Preller K, Vollenweider F, Schleifer C, Adkinson B, Kolobaric A, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, D. M, Anticevic A. P.499 Ketamine's influence on global resting-state functional connectivity and individual variation in neuro-behavioural relationships. European Neuropsychopharmacology 2020, 40: s278-s279. DOI: 10.1016/j.euroneuro.2020.09.363.
• Robert T. Malison, M.D. (1959–2020)Krystal J. Robert T. Malison, M.D. (1959–2020). Neuropsychopharmacology 2020, 45: 2133-2134. PMCID: PMC7547671, DOI: 10.1038/s41386-020-00817-2.
• PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studiesBhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
• A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive DisorderNemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
• Preliminary Phenotypic Feature Capture During Clinical InteractionBarron D, Heisig S, Norel R, Agurto C, Quagan B, Powers A, Baker J, Constable R, Cecchi G, Krystal J. Preliminary Phenotypic Feature Capture During Clinical Interaction. Biological Psychiatry 2020, 87: s212-s213. DOI: 10.1016/j.biopsych.2020.02.552.
• What Can Machine Learning Do for Psychiatry?Barron D, Bzdok D, Krystal J, Constable R. What Can Machine Learning Do for Psychiatry? Biological Psychiatry 2020, 87: s462. DOI: 10.1016/j.biopsych.2020.02.1176.
• Transcriptomic Organization of Human Posttraumatic Stress DisorderGirgenti M, Wang J, Ji D, Cruz D, Group T, Program M, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic Organization of Human Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s122. DOI: 10.1016/j.biopsych.2020.02.330.
• Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and DiseaseWendt F, Pathak G, Lencz T, Krystal J, Gelernter J, Polimanti R. Education and Socioeconomic Status Mask the Identification of Brain Cell Types in GWAS of Mental Health and Disease. Biological Psychiatry 2020, 87: s110. DOI: 10.1016/j.biopsych.2020.02.302.
• Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress DisorderStone L, Girgenti M, Krystal J, Duman R, Group T. Neural Transcriptomic Alterations Associated With Neuropeptide Y and Ghrelin in Posttraumatic Stress Disorder. Biological Psychiatry 2020, 87: s421-s422. DOI: 10.1016/j.biopsych.2020.02.1075.
• A Non–D2-Receptor-Binding Drug for the Treatment of SchizophreniaKoblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, Loebel A. A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia. New England Journal Of Medicine 2020, 382: 1497-1506. PMID: 32294346, DOI: 10.1056/nejmoa1911772.
• Ronald S. Duman (1954–2020)Nestler E, Krystal J. Ronald S. Duman (1954–2020). Neuron 2020, 105: 769-770. DOI: 10.1016/j.neuron.2020.02.018.
• Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycinAbdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
• Ronald S. Duman, Ph.D. (1954–2020)Krystal J, Nestler E, Picciotto M. Ronald S. Duman, Ph.D. (1954–2020). Neuropsychopharmacology 2020, 45: 1078-1078. PMCID: PMC7162938, DOI: 10.1038/s41386-020-0642-y.
• Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trialKrishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.
• Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans StudyAverill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
• In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideationDavis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 11490-11495. PMID: 31085640, PMCID: PMC6561298, DOI: 10.1073/pnas.1818871116.
• S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With SchizophreniaMoujaes F, Preller K, Vollenweider F, Schleifer C, Ji J, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, Murray J, Anticevic A. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia. Biological Psychiatry 2019, 85: s358. DOI: 10.1016/j.biopsych.2019.03.910.
• S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain ModulationBurt J, Preller K, Demirtas M, Ji J, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation. Biological Psychiatry 2019, 85: s365. DOI: 10.1016/j.biopsych.2019.03.926.
• 142. Synaptic Density Alterations are Associated With Depression Severity and Network AlterationsHolmes S, Scheinost D, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Pietrzak R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations. Biological Psychiatry 2019, 85: s59. DOI: 10.1016/j.biopsych.2019.03.156.
• F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional ConnectivityMoujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity. Biological Psychiatry 2019, 85: s289. DOI: 10.1016/j.biopsych.2019.03.732.
• T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working MemoryCho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory. Biological Psychiatry 2019, 85: s204-s205. DOI: 10.1016/j.biopsych.2019.03.516.
• S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional ConnectivityBarron D, Gao S, Greene A, Constable R, Krystal J, Scheinost D. S179. Transdiagnostic Prediction of Memory and Executive Function From Whole-Brain Functional Connectivity. Biological Psychiatry 2019, 85: s366-s367. DOI: 10.1016/j.biopsych.2019.03.930.
• 26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. VeteransMontalvo-Ortiz J, Gelernter J, Southwick S, Krystal J, Pietrzak R. 26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. Veterans. Biological Psychiatry 2019, 85: s11. DOI: 10.1016/j.biopsych.2019.03.040.
• T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for SchizophreniaHamilton H, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. T161. Effects of Ketamine Administration on the P300 Event-Related Potential: Implications for Schizophrenia. Biological Psychiatry 2019, 85: s191. DOI: 10.1016/j.biopsych.2019.03.484.
• T174. Examining the Neurobiological Progression of Early Course SchizophreniaKolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, Krystal J, Gong Q. T174. Examining the Neurobiological Progression of Early Course Schizophrenia. Biological Psychiatry 2019, 85: s196-s197. DOI: 10.1016/j.biopsych.2019.03.497.
• S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning ModelKaye A, Ressler K, Krystal J. S16. PTSD as a Threat Mood: Insights From a Reinforcement Learning Model. Biological Psychiatry 2019, 85: s302. DOI: 10.1016/j.biopsych.2019.03.767.
• Lower synaptic density is associated with depression severity and network alterationsHolmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
• Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel TreatmentsDuman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron 2019, 102: 75-90. PMID: 30946828, PMCID: PMC6450409, DOI: 10.1016/j.neuron.2019.03.013.
• Ketamine: A Paradigm Shift for Depression Research and TreatmentKrystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron 2019, 101: 774-778. PMID: 30844397, PMCID: PMC6560624, DOI: 10.1016/j.neuron.2019.02.005.
• Neural computations of threat in the aftermath of combat traumaHoman P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.
• Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptorPreller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. ELife 2018, 7: e35082. PMID: 30355445, PMCID: PMC6202055, DOI: 10.7554/elife.35082.
• Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult DrinkersZhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.
• Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depressionZhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
• The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjectsAbdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology 2018, 43: 2154-2160. PMID: 29977074, PMCID: PMC6098048, DOI: 10.1038/s41386-018-0136-3.
• DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChipZhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2018 DOI: 10.1038/protex.2018.080.
• Erratum to: Ketamine: A Promising Rapid-Acting AntidepressantWilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.
• F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSDHillmer A, Esterlis I, Davis M, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSD. Biological Psychiatry 2018, 83: s237-s238. DOI: 10.1016/j.biopsych.2018.02.616.
• S232. Effects of Incentive Presentation on Spatial Working Memory PerformanceCho Y, Schleifer C, Moujaes F, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance. Biological Psychiatry 2018, 83: s438. DOI: 10.1016/j.biopsych.2018.02.1124.
• T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal CortexGirgenti M, Cruz D, Williamson D, Friedman M, Krystal J, Duman R. T103. Transcriptome Alterations for Posttraumatic Stress Disorder in Human Prefrontal Cortex. Biological Psychiatry 2018, 83: s168. DOI: 10.1016/j.biopsych.2018.02.439.
• F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major DepressionZhou H, Zhong Z, Bass N, Krystal J, Farrer L, Kranzler H, Gelernter J. F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression. Biological Psychiatry 2018, 83: s288-s289. DOI: 10.1016/j.biopsych.2018.02.744.
• 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVEKrystal J. 2. MICROCIRCUITS, MACROCIRCUITS, AND CORTICOL DYSFUNCTION IN SCHIZOPHRENIA: A COMPUTATIONAL AND TRANSLATIONAL NEUROSCIENCE PERSPECTIVE. Schizophrenia Bulletin 2018, 44: s1-s1. PMCID: PMC5887654, DOI: 10.1093/schbul/sby014.001.
• Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational NeuroscienceAnticevic A, Krystal J, Murray J. Meeting Emerging Challenges and Opportunities in Psychiatry Through Computational Neuroscience. 2018, xiii-xxxi. DOI: 10.1016/b978-0-12-809825-7.02004-6.
• DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChipZhang X, Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, Krystal J, Xu K. DNA methylation signatures analysis with Illumina Infinitum MethylationEPIC and Infinium Human Methylation 450K BeadChip. Protocol Exchange 2017 DOI: 10.1038/protex.2017.135.
• Polygenic Scores for Major Depressive Disorder and Risk of Alcohol DependenceAndersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
• Ketamine: A Promising Rapid-Acting AntidepressantWilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.
• My Path to PsychiatryKrystal J. My Path to Psychiatry. Psychiatric News 2017, 52: 1-1. DOI: 10.1176/appi.pn.2017.10b1.
• KL.01.01 Targeting glutamate in psychiatric diseaseKrystal J. KL.01.01 Targeting glutamate in psychiatric disease. European Neuropsychopharmacology 2017, 27: s521. DOI: 10.1016/s0924-977x(17)30985-9.
• Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidenceHolmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
• 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A ReceptorPreller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951 Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor. Biological Psychiatry 2017, 81: s385. DOI: 10.1016/j.biopsych.2017.02.677.
• 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress DisorderDavis M, Holmes S, Pietrzak R, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Carson R, Krystal J, Esterlis I. 18 In Vivo Quantification of mGluR5 Availability in Posttraumatic Stress Disorder. Biological Psychiatry 2017, 81: s8. DOI: 10.1016/j.biopsych.2017.02.029.
• 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging StudyEsterlis I, Pietrzak R, DellaGioia N, Matuskey D, Huang H, Krystal J, Duman R, Carson R, Finnema S. 389 In Vivo Evidence of Lower Synaptic Density in Depression and Associated Mood and Cognitive Deficits: A [11C]UCB-J PET Imaging Study. Biological Psychiatry 2017, 81: s159. DOI: 10.1016/j.biopsych.2017.02.406.
• 399 Ketamine and Guanfacine Effects on Activation and Connectivity during Working Memory: A Functional Magnetic Resonance Imaging InvestigationDriesen N, McCarthy G, Arnsten A, Morgan P, He G, Bloch M, Krystal J. 399 Ketamine and Guanfacine Effects on Activation and Connectivity during Working Memory: A Functional Magnetic Resonance Imaging Investigation. Biological Psychiatry 2017, 81: s163. DOI: 10.1016/j.biopsych.2017.02.416.
• 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional ConnectivityAnticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423 NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity. Biological Psychiatry 2017, 81: s172-s173. DOI: 10.1016/j.biopsych.2017.02.907.
• 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like SymptomsCortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
• 961 Incentives to Perform: The Effects of Reward on Working MemoryCho Y, Schleifer C, Starc M, Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961 Incentives to Perform: The Effects of Reward on Working Memory. Biological Psychiatry 2017, 81: s389. DOI: 10.1016/j.biopsych.2017.02.687.
• 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch NegativityHamilton H, Kort N, Ford J, Roach B, Gunduz-Bruce H, Krystal J, Jaeger J, Reinhart R, Mathalon D. 540 Effects of N-methyl-D-aspartate Glutamate Receptor Disruption and Nicotinic Acetylcholine Enhancement on Mismatch Negativity. Biological Psychiatry 2017, 81: s219. DOI: 10.1016/j.biopsych.2017.02.1148.
• 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal ApproachAkiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
• 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma OscillationsFerri J, Ford J, Roach B, Perry-O׳Leary D, Jaeger J, Gunduz-Bruce H, Krystal J, Mathalon D. 539 Ketamine, an NMDA-Receptor Antagonist, Mimics the Patterns of Intrinsically but Not Extrinsically Driven Gamma Oscillations. Biological Psychiatry 2017, 81: s218-s219. DOI: 10.1016/j.biopsych.2017.02.1147.
• 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC ConsortiaMorey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
• Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health CareKnickman J, Krishnan K, Pincus H, Blanco C, Blazer D, Coye M, Krystal J, Rauch S, Simon G, Vitiello B. Improving Access to Effective Care for People Who Have Mental Health and Substance Use Disorders: A Vital Direction for Health and Health Care. NAM Perspectives 2016, 6 DOI: 10.31478/201609v.
• Speaker 3: John Krystal, USAKrystal J, Anticevic A, Yang G, Driesen N, Cortes-Briones J, Stone J, Wang X, Murray J. Speaker 3: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 5-5. PMCID: PMC5616483, DOI: 10.1093/ijnp/pyw042.007.
• Speaker 4: John Krystal, USAKrystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
• Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressantsDuman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.
• Functional hierarchy underlies preferential connectivity disturbances in schizophreniaYang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 113: e219-e228. PMID: 26699491, PMCID: PMC4720350, DOI: 10.1073/pnas.1508436113.
• KetamineAbdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
• Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawalCosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
• Computational PsychiatryWang XJ, Krystal JH. Computational Psychiatry. Neuron 2014, 84: 638-654. PMID: 25442941, PMCID: PMC4255477, DOI: 10.1016/j.neuron.2014.10.018.
• Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and MiceBaldan L, Williams K, Gallezot J, Pogorelov V, Rapanelli M, Crowley M, Anderson G, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza K, Ercan-Sencicek A, Krusong K, Leventhal B, Ohtsu H, Bloch M, Hughes Z, Krystal J, Mayes L, de Araujo I, Ding Y, State M, Pittenger C. Histidine Decarboxylase Deficiency Causes Tourette Syndrome: Parallel Findings in Humans and Mice. Neuron 2014, 82: 1186-1187. DOI: 10.1016/j.neuron.2014.05.023.
• KetamineAbdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.
• 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIAAnticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52-s53. DOI: 10.1016/s0920-9964(14)70172-0.
• Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIARosenheck R, Leatherman S, Krystal J, Liang M. Poster #T200 SUBGROUP ANALYSIS IN A RANDOMIZED CLINICAL TRIAL OF LONG-ACTING INJECTABLE RISPERIDONE AND ORAL ANTIPSYCHOTICS IN UNSTABLE CHRONIC SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s360. DOI: 10.1016/s0920-9964(14)71016-3.
• Psychiatric Disorders: Diagnosis to TherapyKrystal JH, State MW. Psychiatric Disorders: Diagnosis to Therapy. Cell 2014, 157: 201-214. PMID: 24679536, PMCID: PMC4104191, DOI: 10.1016/j.cell.2014.02.042.
• Pl.2 - KETAMINEKrystal J. Pl.2 - KETAMINE. Behavioural Pharmacology 2013, 24: e1. DOI: 10.1097/01.fbp.0000434680.00108.7d.
• S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependenceKrystal J. S.19.04 Glutamatergic contributions to reward dysfunction in alcohol dependence. European Neuropsychopharmacology 2013, 23: s141. DOI: 10.1016/s0924-977x(13)70198-6.
• Increased brain uptake and oxidation of acetate in heavy drinkersJiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. Journal Of Clinical Investigation 2013, 123: 1605-1614. PMID: 23478412, PMCID: PMC3613911, DOI: 10.1172/jci65153.
• Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficitsAnticevic A, Krystal J, Barch D. Translational cognitive neuroscience of schizophrenia: bridging neurocognitive and computational approaches toward understanding cognitive deficits. 2013, 193-230. DOI: 10.1017/cbo9781139003872.013.
• NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophreniaAnticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 16720-16725. PMID: 23012427, PMCID: PMC3478611, DOI: 10.1073/pnas.1208494109.
• P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generationStone J, Dietrich C, Edden R, Mehta M, De Simoni S, Reed L, Krystal J, Nutt D, Barker G. P.3.001 Ketamine-induced changes in anterior cingulate glutamate levels correlate with positive symptom generation. European Neuropsychopharmacology 2012, 22: s52-s53. DOI: 10.1016/s0924-977x(12)70054-8.
• Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1qZuo L, Gelernter J, Zhang C, Zhao H, Lu L, Kranzler H, Malison R, Li C, Wang F, Zhang X, Deng H, Krystal J, Zhang F, Luo X. Erratum: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q. Neuropsychopharmacology 2011, 37: 581-582. PMCID: PMC3242324, DOI: 10.1038/npp.2011.271.
• New Frontiers in Animal Research of Psychiatric IllnessKaffman A, Krystal J. New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: 3-30. PMID: 22231804, PMCID: PMC3337084, DOI: 10.1007/978-1-61779-458-2_1.
• Erratum: New Frontiers in Animal Research of Psychiatric IllnessKaffman A, Krystal J. Erratum: New Frontiers in Animal Research of Psychiatric Illness. 2011, 829: e1-e1. DOI: 10.1007/978-1-61779-458-2_38.
• Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized TrialKrystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C, Group F. Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD: A Randomized Trial. JAMA 2011, 306: 493-502. PMID: 21813427, DOI: 10.1001/jama.2011.1080.
• Biological Psychiatry: A Time of Opportunity, a Time of ChallengeKrystal J. Biological Psychiatry: A Time of Opportunity, a Time of Challenge. Biological Psychiatry 2011, 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020.
• P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency departmentLarkin G, Beautrais A, Turelli R, Sanacora G, Powsner S, Lippmann M, Krystal J. P03-437 - A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department. European Psychiatry 2011, 26: 1607. DOI: 10.1016/s0924-9338(11)73311-9.
• Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol DependenceKrystal J, Petrakis I, Limoncelli D, Nappi S, Trevisan L, Pittman B, D'Souza D. Erratum: Characterization of the Interactive Effects of Glycine and D-Cycloserine in Men: Further Evidence for Enhanced NMDA Receptor Function Associated with Human Alcohol Dependence. Neuropsychopharmacology 2011, 36: 911-911. PMCID: PMC3055722, DOI: 10.1038/npp.2011.2.
• Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of SchizophreniaKrystal J, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. 2010, 433-461. DOI: 10.1002/9781444327298.ch21.
• 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency DepartmentLarkin G, Beautrais A, Powsner S, Sanacora G, Krystal J, Turelli R, Lippmann M. 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency Department. Annals Of Emergency Medicine 2010, 56: s53. DOI: 10.1016/j.annemergmed.2010.06.204.
• Neurotransmitter Systems in Bipolar DisorderNakic M, Krystal J, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder. 2010, 210-227. DOI: 10.1002/9780470661277.ch16.
• In ReplySen S, Kranzler H, Krystal J, Speller H, Chan G, Gelernter J, Guille C. In Reply. JAMA Psychiatry 2010, 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53.
• IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIACavus I, Guglielmino R, Ford J, Roach B, Krystal J, Gueorguieva R, Mathalon D. IMPAIRED LONG-TERM POTENTIATION OF THE VISUAL EVOKED POTENTIAL IN SCHIZOPHRENIA. Schizophrenia Research 2010, 117: 244-245. DOI: 10.1016/j.schres.2010.02.373.
• NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in HumansDriesen N, McCarthy G, Bhagwagar Z, Calhoun V, D'Souza D, Holub J, Morgan P, Krystal J. NMDA Receptor Antagonist Ketamine Produces Opposing Effects on Resting and Task-Related Brain Activation During Working Memory in Humans. NeuroImage 2009, 47: s145. DOI: 10.1016/s1053-8119(09)71458-2.
• Biological Psychiatry: Real ProgressKrystal J. Biological Psychiatry: Real Progress. Biological Psychiatry 2009, 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026.
• Ethanol-like effects of thiopental and ketamine in healthy humansDickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.
• Serotonin-1B receptor imaging in PTSDNeumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
• Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkersEsterlis I, Bois F, Cosgrove K, Stiklus S, Perry E, Tamagnan G, Seibyl J, Krystal J, Staley J. Sex differences in nicotinic acetylcholine receptor availability in heavy alcohol drinkers. NeuroImage 2008, 41: t183. DOI: 10.1016/j.neuroimage.2008.04.150.
• New probes for imaging dopamine transmission in at risk subjects for alcoholismUrban N, Martinez D, Zhou Y, Toda M, Xu X, Kegeles L, Slifstein M, Pearlson G, Krystal J, Abi-Dargham A. New probes for imaging dopamine transmission in at risk subjects for alcoholism. NeuroImage 2008, 41: t143. DOI: 10.1016/j.neuroimage.2008.04.111.
• The Neuroscience Research Program at the Connecticut Mental Health CenterHeninger G, Krystal J, Duman R, Bunney B, Bowers M, Aghajanian G. The Neuroscience Research Program at the Connecticut Mental Health Center. 2007, 77-95. DOI: 10.1002/9780470994580.ch4.
• Biological Psychiatry: Increasing ImpactKrystal J. Biological Psychiatry: Increasing Impact. Biological Psychiatry 2007, 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021.
• ReplyKaufman J, Massey J, Krystal J, Gelernter J. Reply. Biological Psychiatry 2007, 61: 1113-1115. DOI: 10.1016/j.biopsych.2006.07.004.
• Neurobiology and Treatment of DepressionNeumeister A, Charney D, Sanacora G, Krystal J. Neurobiology and Treatment of Depression. 2007 DOI: 10.1002/9780470101001.hcn018.
• Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and DiazepamKrupitsky E, Rudenko A, Burakov A, Slavina T, Grinenko A, Pittman B, Gueorguieva R, Petrakis I, Zvartau E, Krystal J. Antiglutamatergic Strategies for Ethanol Detoxification: Comparison With Placebo and Diazepam. Alcoholism Clinical And Experimental Research 2007, 0: 070212174136008-???. DOI: 10.1111/j.1530-0277.2007.00344.x.
• Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-ArPittman B, Gueorguieva R, Krupitsky E, Rudenko A, Flannery B, Krystal J. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: A Factor Analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar. Alcoholism Clinical And Experimental Research 2007, 0: 070212174136010-???. DOI: 10.1111/j.1530-0277.2007.00345.x.
• Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative StudyGelernter J, Gueorguieva R, Kranzler H, Zhang H, Cramer J, Rosenheck R, Krystal J. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study. Alcoholism Clinical And Experimental Research 2007, 0: 070212174136005-???. DOI: 10.1111/j.1530-0277.2007.00339.x.
• Psychoactive DrugsD'Souza D, Krystal J. Psychoactive Drugs. 2006 DOI: 10.1002/0470018860.s00599.
• [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokersStaley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers. NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
• Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or DependencePerry E, Gil R, Miles D, Brenner L, Macdougall L, Johnson R, Degen K, Gueorguieva R, Petrakis I, Krystal J, D'Souza D. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence. Journal Of Dual Diagnosis 2005, 1: 37-47. DOI: 10.1300/j374v01n01_04.
• Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back AgainMason G, Bendszus M, Meyerhoff D, Hetherington H, Schweinsburg B, Ross B, Taylor M, Krystal J. Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again. Alcoholism Clinical And Experimental Research 2005, 29: 150-158. PMID: 15895489, DOI: 10.1097/01.alc.0000150010.72739.58.
• Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism SpectrumDaurignac E, Toga A, Jones D, Aronen H, Hommer D, Jernigan T, Krystal J, Mathalon D. Applications of Morphometric and Diffusion Tensor Magnetic Resonance Imaging to the Study of Brain Abnormalities in the Alcoholism Spectrum. Alcoholism Clinical And Experimental Research 2005, 29: 159-166. PMID: 15895490, DOI: 10.1097/01.alc.0000150891.72900.62.
• P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol cravingTsoy M, Krupitsky E, Neznanova O, Burakov A, Didenko T, Masalov D, Romanova T, Bespalov A, Zvartau E, Krystal J. P.3.10 Ethanol-like effects of N-methyl-d-aspartatereceptors antagonist memantine, and its ability to prevent cue induced alcohol craving. European Neuropsychopharmacology 2005, 15: s59-s60. DOI: 10.1016/s0924-977x(05)80177-4.
• Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophreniaHoffman R, Mathalon D, Ford J, Krystal J. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia. Behavioral And Brain Sciences 2004, 27: 797-798. DOI: 10.1017/s0140525x04320182.
• ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE.Krupitsky E, Rudenko A, Burakov A, Zvartau E, Slavina T, Grinenko A, Krystal J. ANTI-GLUTAMATE TREATMENTS FOR ALCOHOL DETOXIFICATION: A DOUBLE-BLIND PLACEBO-CONTROLLED PILOT STUDY OF LAMOTRIGINE, MEMANTINE, AND TOPIRAMATE. Alcoholism Clinical And Experimental Research 2004, 28: 50a. DOI: 10.1097/00000374-200408002-00258.
• HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT.Krishnan-Sarin S, Shih J, Krystal J, O’Malley S. HPA AXIS RESPONSIVITY AND ALCOHOL DRINKING: INTERACTIVE EFFECTS OF FAMILY HISTORY OF ALCOHOLISM AND NALTREXONE TREATMENT. Alcoholism Clinical And Experimental Research 2004, 28: 73a. DOI: 10.1097/00000374-200408002-00397.
• Molecular genetics and psychopharmacologyMalhotra A, Krystal J. Molecular genetics and psychopharmacology. Psychopharmacology 2004, 174: 439-440. DOI: 10.1007/s00213-004-1947-y.
• Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophreniaPetrakis I, O’Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal J, VA Naltrexone Study Collaboration Group. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology 2004, 174: 300-300. DOI: 10.1007/s00213-004-1881-z.
• Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophreniaD'souza D, Cho H, Perry E, Krystal J. Cannabinoid ‘model’ psychosis, dopamine–cannabinoid interactions and implications for schizophrenia. 2004, 142-165. DOI: 10.1017/cbo9780511543630.012.
• Blood dyscrasiasCho H, Krystal J, D’Souza D. Blood dyscrasias. 2004, 221-238. DOI: 10.1093/med/9780198527480.003.0012.
• Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorderQin J, Mitchell K, Johnson M, Krystal J, Southwick S, Rasmusson A, Allen E. Reactions to and memories for the September 11, 2001 terrorist attacks in adults with posttraumatic stress disorder. Applied Cognitive Psychology 2003, 17: 1081-1097. DOI: 10.1002/acp.987.
• S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSDRasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD. European Neuropsychopharmacology 2003, 13: s151-s152. DOI: 10.1016/s0924-977x(03)91680-4.
• S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosisKrystal J, D'Souza D, Mathalon D, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis. European Neuropsychopharmacology 2003, 13: s96. DOI: 10.1016/s0924-977x(03)91600-2.
• Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and OutcomesCramer J, Rosenheck R, Kirk G, Krol W, Krystal J, 425 F. Medication Compliance Feedback and Monitoring in a Clinical Trial: Predictors and Outcomes. Value In Health 2003, 6: 566-573. PMID: 14627063, DOI: 10.1046/j.1524-4733.2003.65269.x.
• Impact of nicotine on brain function in smokers with schizophreniaJacobsen L, Mencl W, D'Souza D, Pugh K, Skudlarski P, Abi-Saab W, Krystal J. Impact of nicotine on brain function in smokers with schizophrenia. Schizophrenia Research 2003, 60: 223-224. DOI: 10.1016/s0920-9964(03)81196-9.
• One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinationsHoffman R, Hawkins K, Anderson A, Buchanan R, Wu K, Hampson M, Gueorguieva R, Carroll K, Spencer D, Krystal J. One hertz repetitive transcranial magnetic stimulation delivered to brain areas underlying speech perception reduces persistent auditory hallucinations. Schizophrenia Research 2003, 60: 285-286. DOI: 10.1016/s0920-9964(03)80467-x.
• Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humansD'Souza D, Perry E, Riccardi P, Abi-Saab W, Krystal J. Cannabinoids and psychosis: Pharmacological studies with IV delta-9-THC in humans. Schizophrenia Research 2003, 60: 310. DOI: 10.1016/s0920-9964(03)80247-5.
• The Neurochemistry of SchizophreniaMoghaddam B, Krystal J. The Neurochemistry of Schizophrenia. 2003, 349-364. DOI: 10.1002/9780470987353.ch19.
• Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and TreatmentKrystal J, Petrakis I, D'Souza D, Mason G, Trevisan L. Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment. 2002, 0: 389-398. DOI: 10.1385/1-59259-306-2:389.
• PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIALCramer J, Rosenheck R, Krystal J, Kirk G, Krol W. PMH1 USEFULNESS OF ELECTRONIC COMPLIANCE DATA IN AN EFFECTIVENESS TRIAL. Value In Health 2002, 5: 226. DOI: 10.1016/s1098-3015(10)61067-4.
• Naltrexone in the Treatment of Alcohol DependenceKrystal J, Cramer J, Krol W, Kirk G, Rosenheck R. Naltrexone in the Treatment of Alcohol Dependence. New England Journal Of Medicine 2001, 345: 1734-1739. PMID: 11742047, DOI: 10.1056/nejmoa011127.
• Lamotrigine in the treatment of depersonalization disorder.Sierra M, Phillips M, Lambert M, Senior C, David A, Krystal J. Lamotrigine in the treatment of depersonalization disorder. The Journal Of Clinical Psychiatry 2001, 62: 826-7. PMID: 11816874, DOI: 10.4088/jcp.v62n1012b.
• Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”Krystal J, D’Souza D. Comment on “ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D2 receptor”. Biological Psychiatry 2001, 50: 555. PMID: 11600110, DOI: 10.1016/s0006-3223(01)01258-6.
• NMDA receptor regulation of memory and behavior in humansNewcomer J, Krystal J. NMDA receptor regulation of memory and behavior in humans. Hippocampus 2001, 11: 529-542. PMID: 11732706, DOI: 10.1002/hipo.1069.
• Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel AntagonistsKrupitsky E, Burakov A, Romanova T, Grinenko N, Grinenko A, Fletcher J, Petrakis I, Krystal J. Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men: Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists. Neuropsychopharmacology 2001, 25: 936-947. PMID: 11750186, DOI: 10.1016/s0893-133x(01)00346-3.
• Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic PatientsPetrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcoholism Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.
• Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic PatientsPetrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue-Induced Craving in Abstinent Alcoholic Patients. Alcoholism Clinical And Experimental Research 2001, 25: 1151-1155. DOI: 10.1097/00000374-200108000-00009.
• A neurobiological basis for substance abuse comorbidity in schizophreniaChambers R, Krystal J, Self D. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry 2001, 50: 71-83. PMID: 11526998, PMCID: PMC2913410, DOI: 10.1016/s0006-3223(01)01134-9.
• CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERSKrystal J, D'Souza D, Sanacora G, Goddard A, Charney D. CURRENT PERSPECTIVES ON THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA, DEPRESSION, AND ANXIETY DISORDERS. Medical Clinics Of North America 2001, 85: 559-577. PMID: 11349473, DOI: 10.1016/s0025-7125(05)70329-1.
• Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissãoMason G, Behar K, Krystal J, Rothman D. Aplicações da ressonância magnética para medidas espectroscópicas da neurotransmissão. Brazilian Journal Of Psychiatry 2001, 23: 6-10. DOI: 10.1590/s1516-44462001000500004.
• Methadone patients exhibit increased startle and cortisol response after intravenous yohimbineStine S, Grillon C, Morgan III C, Kosten T, Charney D, Krystal J. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology 2001, 154: 274-281. PMID: 11351934, DOI: 10.1007/s002130000644.
• Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulationBoutros N, Lisanby S, Tokuno H, Torello M, Campbell D, Berman R, Malison R, Krystal J, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry 2001, 49: 369-373. PMID: 11239908, DOI: 10.1016/s0006-3223(00)00948-3.
• Psychopharmacological challenge studies in psychiatric researchD'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260020024187.
• Psychopharmacological challenge studies in psychiatric researchD'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.
• Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential StudyBoutros N, Reid M, Petrakis I, Campbell D, Torello M, Krystal J. Similarities in the Disturbances in Cortical Information Processing in Alcoholism and Aging: A Pilot Evoked Potential Study. International Psychogeriatrics 2000, 12: 513-525. PMID: 11263717, DOI: 10.1017/s1041610200006621.
• Cocaine use and the mid-latency auditory evoked responsesBoutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.
• Serotonin Receptors as Targets of Antipsychotic MedicationsAbi-Dargham A, Krystal J. Serotonin Receptors as Targets of Antipsychotic Medications. 2000, 20000744: 79-107. DOI: 10.1201/9781420041774.ch6.
• Comorbidity of psychiatric and substance abuse disordersGeorge T, Krystal J. Comorbidity of psychiatric and substance abuse disorders. Current Opinion In Psychiatry 2000, 13: 327-331. DOI: 10.1097/00001504-200005000-00015.
• 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinationsHoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations. Biological Psychiatry 2000, 47: s122-s123. DOI: 10.1016/s0006-3223(00)00670-3.
• 304. Cortical GABA reduced in unipolar but not bipolar depressionMason G, Sanacora G, Anand A, Epperson C, Goddard A, Rothman D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression. Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00568-0.
• 305. Reduced cortical GABA in depression is not due to decreased gray matterSanacora G, Mason G, Rothman D, Epperson C, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter. Biological Psychiatry 2000, 47: s92. DOI: 10.1016/s0006-3223(00)00569-2.
• 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis studyAbi-Saab W, Spencer D, Srihari V, Thompson J, Roth R, Sherwin R, Krystal J. 458. Extracellular levels of GABA and glutamate increase in response to direct electrical stimulation of the hippocampus in humans: an in vivo microdialysis study. Biological Psychiatry 2000, 47: s140. DOI: 10.1016/s0006-3223(00)00728-9.
• 203. Working memory: constructs, neural circuits, and pharmacological modulationBelger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation. Biological Psychiatry 2000, 47: s62. DOI: 10.1016/s0006-3223(00)00295-x.
• 455. Sensory gating in older healthy adultsBoutros N, Reid C, Campbell D, Torello M, Krystal J. 455. Sensory gating in older healthy adults. Biological Psychiatry 2000, 47: s139. DOI: 10.1016/s0006-3223(00)00725-3.
• IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humansD’Souza D, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper L, Zuzarte E, Charney D, Krystal J. IV glycine and oral d-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry 2000, 47: 450-462. PMID: 10704956, DOI: 10.1016/s0006-3223(99)00133-x.
• Transcranial magnetic stimulation and auditory hallucinations in schizophreniaHoffman R, Boutros N, Hu S, Berman R, Krystal J, Charney D. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. The Lancet 2000, 355: 1073-1075. PMID: 10744097, DOI: 10.1016/s0140-6736(00)02043-2.
• Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CITLaruelle M, Abi-Dargham A, van Dyck C, Gil R, D’Souza D, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [123I]β-CIT. Biological Psychiatry 2000, 47: 371-379. PMID: 10704949, DOI: 10.1016/s0006-3223(99)00257-7.
• Antidepressant effects of ketamine in depressed patientsBerman R, Cappiello A, Anand A, Oren D, Heninger G, Charney D, Krystal J. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry 2000, 47: 351-354. PMID: 10686270, DOI: 10.1016/s0006-3223(99)00230-9.
• Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functionsKrystal J, Bennett A, Abi-Saab D, Belger A, Karper L, D’Souza D, Lipschitz D, Abi-Dargham A, Charney D. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry 2000, 47: 137-143. PMID: 10664830, PMCID: PMC10060085, DOI: 10.1016/s0006-3223(99)00097-9.
• Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging StudiesSanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.
• Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate releaseAnand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90372-4.
• Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactionsKrystal J, D'Souza D, Belger A, Madonick S, Cossello K. Ketamine and amphetamine interactions in healthy humans: Further insights into glutamate-dopamine interactions. Schizophrenia Research 2000, 41: 235-236. DOI: 10.1016/s0920-9964(00)90891-0.
• Dose-response of acute ethanol administration in schizophrenic patients and controlsD'Souza D, Madonick S, Abi-Saab W, Wray Y, MacDougall L, Brush L, Cassello K, Krystal J. Dose-response of acute ethanol administration in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 247. DOI: 10.1016/s0920-9964(00)90923-x.
• Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controlsD'Souza D, Abi-Saab W, Madonick S, Wray Y, Forselius K, MacDougall L, Brush L, Cassello K, Krystal J. Cannabinoids & psychosis: Evidence from studies with I.V THC in schizophrenic patients and controls. Schizophrenia Research 2000, 41: 33. DOI: 10.1016/s0920-9964(00)90371-2.
• The Emerging Neurobiology of Dissociative StatesKrystal J, Bremner J, D’Souza D, Anand A, Southwick S, Charney D. The Emerging Neurobiology of Dissociative States. 2000, 307-320. DOI: 10.1007/978-1-4615-4177-6_22.
• Therapeutic Implications of the Hyperglutamatergic Effects of NMDA AntagonistsKrystal J, Belger A, D'Souza D, Anand A, Charney D, Aghajanian G, Moghaddam B. Therapeutic Implications of the Hyperglutamatergic Effects of NMDA Antagonists. Neuropsychopharmacology 1999, 21: s143-s157. DOI: 10.1016/s0893-133x(99)00102-5.
• Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine CommitteeGibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion(R): Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993-1002. DOI: 10.1080/01621459.1999.10473852.
• Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine CommitteeGibbons R, Brown B, Azarnoff D, Bunney W, Cancro R, Gillin J, Hullett S, Killam K, Krystal J, Kupfer D, Stolley P, Pope A, French G. Assessment of the Safety and Efficacy Data for the Hypnotic Halcion (R) : Results of an Analysis by an Institute of Medicine Committee. Journal Of The American Statistical Association 1999, 94: 993. DOI: 10.2307/2669913.
• Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary reportBoutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.
• [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophreniaVerhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.
• Symptom provocation studies in psychiatric disorders: scientific value, risks, and futureD’Souza D, Berman R, Krystal J, Charney D. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry 1999, 46: 1060-1080. PMID: 10536743, DOI: 10.1016/s0006-3223(99)00209-7.
• NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric DisordersKrystal J, D'Souza C, Petrakis I, Belger A, Berman R, Charney D, AbiSaab W, Madonick S. NMDA Agonists and Antagonists as Probes of Glutamatergic Dysfunction and Pharmacotherapies in Neuropsychiatric Disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. PMID: 10483932, DOI: 10.3109/hrp.7.3.125.
• Nimodipine attenuates psychotigenic effects of ketamine in humansKrupitsky E, Burakov A, Romanova T, Vegso S, Krystal J. Nimodipine attenuates psychotigenic effects of ketamine in humans. European Neuropsychopharmacology 1999, 9: 347. DOI: 10.1016/s0924-977x(99)80514-8.
• NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disordersKrystal J. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review Of Psychiatry 1999, 7: 125-143. DOI: 10.1093/hrp/7.3.125.
• CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?Petrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving? Alcoholism Clinical And Experimental Research 1999, 23: 1336-1341. PMID: 10470976, DOI: 10.1111/j.1530-0277.1999.tb04355.x.
• CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy ControlsPetrakis I, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal J. CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls. Alcoholism Clinical And Experimental Research 1999, 23: 1336. DOI: 10.1097/00000374-199908000-00007.
• Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”Hoffman R, Boutros N, Berman R, Roessler E, Belger A, Krystal J, Charney D. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated “voices”. Biological Psychiatry 1999, 46: 130-132. PMID: 10394483, DOI: 10.1016/s0006-3223(98)00358-8.
• Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant actionDelgado P, Miller H, Salomon R, Licinio J, Krystal J, Moreno F, Heninger G, Charney D. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry 1999, 46: 212-220. PMID: 10418696, DOI: 10.1016/s0006-3223(99)00014-1.
• Interactive effects of subanesthetic ketamine and haloperidol in healthy humansKrystal J, D’Souza D, Karper L, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers Jr. M, Vegso S, Heninger G, Charney D, Bowers M. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology 1999, 145: 193-204. PMID: 10463321, DOI: 10.1007/s002130051049.
• No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in SchizophreniaAbi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin R, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis R. No Evidence of Altered In Vivo Benzodiazepine Receptor Binding in Schizophrenia. Neuropsychopharmacology 1999, 20: 650-661. PMID: 10327433, DOI: 10.1016/s0893-133x(98)00107-9.
• Applications of Magnetic Resonance Spectroscopy to PsychiatrySanacora G, Rothman D, Krystal J. Applications of Magnetic Resonance Spectroscopy to Psychiatry. The Neuroscientist 1999, 5: 192-196. DOI: 10.1177/107385849900500316.
• Changes of benzodiazepine receptors during chronic benzodiazepine administration in humansFujita M, Woods S, Verhoeff N, Abi-Dargham A, Baldwin R, Zoghbi S, Soares J, Jatlow P, Krystal J, Rajeevan N, Charney D, Seibyl J, Innis R. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal Of Pharmacology 1999, 368: 161-172. PMID: 10193652, DOI: 10.1016/s0014-2999(99)00013-8.
• Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patientsKrystal J, D'Souza D, Madonick S, Petrakis I. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research 1999, 35: s35-s49. PMID: 10190224, DOI: 10.1016/s0920-9964(98)00162-5.
• 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRSSanacora G, Mason G, Rothman D, Berman R, Charney D, Ciarcia J, Krystal J. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS. Journal Of Ect 1999, 15: 102. DOI: 10.1097/00124509-199903000-00009.
• Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRIBelger A, Puce A, Krystal J, Gore J, Goldman‐Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping 1998, 6: 14-32. PMID: 9673660, PMCID: PMC6873355, DOI: 10.1002/(sici)1097-0193(1998)6:1<14::aid-hbm2>3.0.co;2-o.
• Naltrexone Augmentation of Neuroleptics in SchizophreniaSernyak M, Glazer W, Heninger G, Charney D, Woods S, Petrakis I, Krystal J, Price L. Naltrexone Augmentation of Neuroleptics in Schizophrenia. Journal Of Clinical Psychopharmacology 1998, 18: 248-251.. PMID: 9617985, DOI: 10.1097/00004714-199806000-00011.
• 24. Quantification of cortical GABA levels in neuropsychiatric patientsSanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients. Biological Psychiatry 1998, 43: s8. DOI: 10.1016/s0006-3223(98)90472-3.
• 435. Dose-response of THC effects in schizophrenics and healthy controlsD'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls. Biological Psychiatry 1998, 43: s130-s131. DOI: 10.1016/s0006-3223(98)90883-6.
• 204. Glutamate, dopamine, the frontal cortex, and schizophreniaKrystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia. Biological Psychiatry 1998, 43: s60. DOI: 10.1016/s0006-3223(98)90652-7.
• 310. Transcranial magnetic stimulation and hallucinated ‘voices’Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’. Biological Psychiatry 1998, 43: s93. DOI: 10.1016/s0006-3223(98)90758-2.
• 295. Sensory gating and cocaine induced paranoiaBoutros N, Krystal J, Gelernter J. 295. Sensory gating and cocaine induced paranoia. Biological Psychiatry 1998, 43: s89. DOI: 10.1016/s0006-3223(98)90743-0.
• Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic PatientsHillbrand M, Spitz R, Foster H, Krystal J, Young J. Creatine Kinase Elevations and Aggressive Behavior in Hospitalized Forensic Patients. Psychiatric Quarterly 1998, 69: 69-82. PMID: 9536476, DOI: 10.1023/a:1022137524475.
• Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS)Bremner J, Krystal J, Putnam F, Southwick S, Marmar C, Charney D, Mazure C. Measurement of dissociative states with the Clinician‐Administered Dissociative States Scale (CADSS). Journal Of Traumatic Stress 1998, 11: 125-136. PMID: 9479681, DOI: 10.1023/a:1024465317902.
• Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humansKrystal J, Karper L, Bennett A, D’Souza D, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner J, Bowers Jr. M, Suckow R, Stetson P, Heninger G, Charney D. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology 1998, 135: 213-229. PMID: 9498724, DOI: 10.1007/s002130050503.
• Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI studyBelger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study. Schizophrenia Research 1998, 29: 106. DOI: 10.1016/s0920-9964(97)88567-2.
• Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress DisorderKrystal J, Nagy L, Rasmusson A, Morgan A, Cottrol C, Southwick S, Charney D. Initial Clinical Evidence of Genetic Contributions to Posttraumatic Stress Disorder. 1998, 657-667. DOI: 10.1007/978-1-4757-5567-1_39.
• Excitatory Amino Acids: Clinical Results with AntagonistsKrystal J. Excitatory Amino Acids: Clinical Results with Antagonists. The Yale Journal Of Biology And Medicine 1998, 71: 409-410. PMCID: PMC2578927.
• Benzodiazepine Receptor AntagonistsAbi-Dargham A, Charney D, Krystal J. Benzodiazepine Receptor Antagonists. CNS Drugs 1997, 8: 244-256. DOI: 10.2165/00023210-199708030-00007.
• Effect of alpha-methyl-para-tyrosine on response to cocaine challengeStine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.
• Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP)Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.
• Noradrenergic Alterations in Posttraumatic Stress DisorderSOUTHWICK S, MORGAN CA, BREMNER A, GRILLON C, KRYSTAL J, NAGY L, CHARNEY D. Noradrenergic Alterations in Posttraumatic Stress Disorder. Annals Of The New York Academy Of Sciences 1997, 821: 125-141. PMID: 9238199, DOI: 10.1111/j.1749-6632.1997.tb48274.x.
• P111 Protocol enhancements for a study of alcohol-dependent patientsCramer J, Krystal J, Rosenheck R, Rounsaville B, Krol W, Collins J. P111 Protocol enhancements for a study of alcohol-dependent patients. Contemporary Clinical Trials 1997, 18: s179. DOI: 10.1016/s0197-2456(97)91206-x.
• Lack of behavioral effects of monoamine depletion in healthy subjectsSalomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.
• 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopyBehar K, Rothman D, D’Souza D, Gil R, Petroff O, Abi-Saab D, Zuzarte E, Hooten M, Petrakis I, Sernyak M, White J, Webb E, Charnay D, Krystal J. 496 Preliminary assessment of cortical gaba levels in schizophrenics using magnetic resonance spectroscopy. Schizophrenia Research 1997, 24: 175-176. DOI: 10.1016/s0920-9964(97)82504-2.
• 617 Dose-related ethanol effects in schizophrenic patientsZuzarte E, D’Souza D, Gil R, Genovese A, White J, Charney D, Krystal J. 617 Dose-related ethanol effects in schizophrenic patients. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82625-4.
• 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controlsD’Souza D, Gil R, Zuzarte E, Zimmerman L, Abi-Saab D, Damon D, White J, Semyak M, Krystal J. 602 Tetrahydrocannabinol effects in schizophrenic subjects & healthy controls. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82610-2.
• 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophreniaBelger A, McNulty A, Krystal J. 356 Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia. Schizophrenia Research 1997, 24: 129. DOI: 10.1016/s0920-9964(97)82364-x.
• 357 Behavioral dissociation of working memory and selective attention functions in schizophreniaBelger A, Taqqu Y, Krystal J. 357 Behavioral dissociation of working memory and selective attention functions in schizophrenia. Schizophrenia Research 1997, 24: 129-130. DOI: 10.1016/s0920-9964(97)82365-1.
• 601 Glycine ketamine interactions in healthy humansD’Souza D, Gil R, Zuzarte E, Abi-Saab D, Damon D, White J, Zimmerman L, Krystal J. 601 Glycine ketamine interactions in healthy humans. Schizophrenia Research 1997, 24: 213. DOI: 10.1016/s0920-9964(97)82609-6.
• 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophreniaZuzarte E, D’Souza D, Gil R, White J, AbiSaab D, Charney D, Krystal J. 618 Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia. Schizophrenia Research 1997, 24: 218. DOI: 10.1016/s0920-9964(97)82626-6.
• 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patientsLaruelle M, Abi-Dargham A, Krystal J, Charney D, Innis R. 507 In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients. Schizophrenia Research 1997, 24: 179. DOI: 10.1016/s0920-9964(97)82515-7.
• AMPT Effects on Cue‐Induced Craving for CocainePetrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.
• O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophreniaD’Souza D, Abi-Saab D, Damon D, White J, Gil R, Krystal J. O-22-11 Dose response of D-Cycloserine, a partial NMDA-Glycine site agonist, in schizophrenia. European Neuropsychopharmacology 1996, 6: 149. DOI: 10.1016/0924-977x(96)87994-6.
• Noradrenergic mechanisms in stress and anxiety: I. preclinical studiesBremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.
• Noradrenergic mechanisms in stress and anxiety: II. Clinical studiesBremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.
• Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent ratsKrystal J, Compere S, Nestler E, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior 1996, 59: 863-866. PMID: 8778878, DOI: 10.1016/0031-9384(95)02206-6.
• 208. Increased striatal dopamine release in drug free schizophrenic subjectsLaruelle M, Abi-Dargham A, van Dyck C, Krystal J, Charney D, Innis R. 208. Increased striatal dopamine release in drug free schizophrenic subjects. Biological Psychiatry 1996, 39: 560. DOI: 10.1016/0006-3223(96)84153-9.
• 326. GABA-serotonin interactions in healthy subjects: Implications for psychosisGil R, D’Souza D, Zuzarte E, Damon D, Genovese A, Boutros N, Abi-Dargham A, Innis R, Charney D, Krystal J. 326. GABA-serotonin interactions in healthy subjects: Implications for psychosis. Biological Psychiatry 1996, 39: 595-596. DOI: 10.1016/0006-3223(96)84271-5.
• Recurrent self-injurious behavior in forensic patientsHillbrand M, Young J, Krystal J. Recurrent self-injurious behavior in forensic patients. Psychiatric Quarterly 1996, 67: 33-45. PMID: 8623037, DOI: 10.1007/bf02244273.
• SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophreniaLaruelle M, Abi-Dargham A, Gil R, van Dyck C, Erdos J, D'Souza D, Rosenblatt W, McCance-Katz E, Zea-Ponce Y, Zoghbi S, Baldwin R, Hoffer P, Krystal J, Charney D, Innis R. SPECT imaging of synaptic dopamine release in drug free schizophrenic patients: An experimental validation of the dopamine hypothesis of schizophrenia. Schizophrenia Research 1996, 18: 198-199. DOI: 10.1016/0920-9964(96)85619-2.
• Dose response of oral D-cycloserine in unmedicated and medicated schizophrenicsD'Souza D, White J, Abi-Saab D, Damon D, Gil R, Zuzarte E, Krystal J. Dose response of oral D-cycloserine in unmedicated and medicated schizophrenics. Schizophrenia Research 1996, 18: 134. DOI: 10.1016/0920-9964(96)85447-8.
• Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRIMcCarthy G, Puce A, Constable T, Krystal J, Gore J, Goldman-Rakic P. Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI. Cerebral Cortex 1996, 6: 600-611. PMID: 8670685, DOI: 10.1093/cercor/6.4.600.
• AMPT Effects on Cue-Induced Craving for CocainePetrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue-Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.3109/10550499608995682.
• Recent Developments in the Neurobiology of DissociationKrystal J, Bennett A, Bremner J, Southwick S, Charney D. Recent Developments in the Neurobiology of Dissociation. 1996, 163-190. DOI: 10.1007/978-1-4899-0310-5_8.
• Mazindol treatment for cocaine dependenceStine S, Krystal J, Kosten T, Charney D. Mazindol treatment for cocaine dependence. Drug And Alcohol Dependence 1995, 39: 245-252. PMID: 8556974, DOI: 10.1016/0376-8716(95)01174-4.
• Functional neuroanatomical correlates of the effects of stress on memoryBremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.
• Functional neuroanatomical correlates of the effects of stress on memoryBremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. DOI: 10.1007/bf02102888.
• Effects of the benzodiazepine antagonist flumazenil in PTSDRandall P, Bremner J, Krystal J, Nagy L, Heninger G, Nicolaou A, Charney D. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38: 319-324. PMID: 7495926, DOI: 10.1016/0006-3223(94)00306-n.
• Glycine Site Agonists of the NMDA Receptor: A ReviewD'Souza D, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review. CNS Neuroscience & Therapeutics 1995, 1: 227-260. DOI: 10.1111/j.1527-3458.1995.tb00285.x.
• Effects of tryptophan depletion on responses to yohimbine in healthy human subjectsGoddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.
• Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamineKrystal J, Karper L, D'Souza C, Webb E, Bennett A, Abi-Dargham A, Petrakis I, Brenner L, Morrissey K, Abi-Saab D, Charney D. Differentiating nmda dysregulation in schizophrenia and alcoholism using ketamine. Schizophrenia Research 1995, 15: 156. DOI: 10.1016/0920-9964(95)95484-q.
• Evaluation of frontal and parietal association cortex contributions to attention using fMRIBelger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI. Schizophrenia Research 1995, 15: 76. DOI: 10.1016/0920-9964(95)95239-6.
• The effect of ketamine on pre-pulse inhibition and attentionKarper L, Grillon C, Abi-Saab D, Morgan C, Charney D, Krystal J. The effect of ketamine on pre-pulse inhibition and attention. Schizophrenia Research 1995, 15: 180. DOI: 10.1016/0920-9964(95)95554-m.
• Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophreniaD'Souza D, Morrissey K, Abi-Saab D, Damon D, Gil R, Bennett A, Krystal J. Intravenous glycine and oral d-Cycloserine effects on CSF Amino acids, plasma hormones and behavior in healthy humans: Implications for schizophrenia. Schizophrenia Research 1995, 15: 147. DOI: 10.1016/0920-9964(95)95456-j.
• Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjectsAbi-Dargham A, Krystal J, Laruelle M, D'Souza D, Zoghbi S, Brenner L, Gil R, Sernyak M, Baldwin R, Zubal G, Hoffer P, Charney D, Innis R. Spect imaging of the benzodiazepine receptor in schizophrenics and healthy subjects. Schizophrenia Research 1995, 15: 75. DOI: 10.1016/0920-9964(95)95236-3.
• Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting testBennett A, Abi-Saab D, Karper L, D'Souza D, Abi-Dargham A, Charney D, Krystal J. Ketamine impairs learning, but not procedural expression, on the wisconsin card sorting test. Schizophrenia Research 1995, 15: 108-109. DOI: 10.1016/0920-9964(95)95333-5.
• Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humansKrystal J, Karper L, Bennett A, Abi-Saab D, D'Souza C, Abi-Dargham A, Charney D. Modulating ketamine-induced thought disorder with lorazepam and haloperidol in humans. Schizophrenia Research 1995, 15: 156-157. DOI: 10.1016/0920-9964(95)95485-r.
• Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbineMcDougle C, Price L, Heninger G, Krystal J, Charney D. Noradrenergic response to acute ethanol administration in heathly subjects: comparison with intravenous yohimbine. Psychopharmacology 1995, 118: 127-135. PMID: 7617798, DOI: 10.1007/bf02245830.
• Discontinuing Anticonvulsant Treatment of AggressionHILLBRAND M, YOUNG J, KRYSTAL J. Discontinuing Anticonvulsant Treatment of Aggression. Journal Of Neuropsychiatry 1995, 7: 116-a-117. PMID: 7711482, DOI: 10.1176/jnp.7.1.116-a.
• Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.
• Neurobiology of Post-Traumatic Stress DisorderSouthwick S, Krystal J, Johnson D, Charney D. Neurobiology of Post-Traumatic Stress Disorder. 1995, 49-72. DOI: 10.1007/978-1-4899-1034-9_4.
• Relationship of Panic Disorder to Posttraumatic Stress Disorder-ReplySouthwick S, Krystal J, Charney D. Relationship of Panic Disorder to Posttraumatic Stress Disorder-Reply. JAMA Psychiatry 1995, 52: 77-78. DOI: 10.1001/archpsyc.1995.03950130077012.
• SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphinevan Dyck C, Rosen M, Thomas H, McMahon T, Wallace E, O'Connor P, Sullivan M, Krystal J, Hoffer P, Woods S, Kosten T. SPECT regional cerebral blood flow alterations in naltrexone-precipitated withdrawal from buprenorphine. Psychiatry Research 1994, 55: 181-191. PMID: 7701033, DOI: 10.1016/0925-4927(94)90013-2.
• Effects of sleep deprivation on serotonin function in depressionSalomon R, Delgado P, Licinio J, Krystal J, Heninger G, Charney D. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry 1994, 36: 840-846. PMID: 7893848, DOI: 10.1016/0006-3223(94)90595-9.
• ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERSKarper L, Bennett A, Erdos J, Krystal J. ANTIPSYCHOTICS, LITHIUM, BENZODIAZEPINES, BETA-BLOCKERS. Journal Of Offender Rehabilitation 1994, 21: 203-222. DOI: 10.1300/j076v21n03_13.
• Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-D'SOUZA D, BENNETT A, ABI-DARGHAM A, KRYSTAL J. Precipitation of a Psychoneuromotor Syndrome by Fluoxetine in a Haloperidol-. Journal Of Clinical Psychopharmacology 1994, 14: 361-362. PMID: 7806697, DOI: 10.1097/00004714-199410000-00018.
• Psychobiologic Research in Post-Traumatic Stress DisorderSouthwick S, Bremner D, Krystal J, Charney D. Psychobiologic Research in Post-Traumatic Stress Disorder. Psychiatric Clinics Of North America 1994, 17: 251-264. PMID: 7937357, DOI: 10.1016/s0193-953x(18)30112-6.
• Short-Term Use of Disulfiram With ClozapineBrenner L, Karper L, Krystal J. Short-Term Use of Disulfiram With Clozapine. Journal Of Clinical Psychopharmacology 1994, 14: 213-214. PMID: 8027424, DOI: 10.1097/00004714-199406000-00016.
• I.V. glycine/d-cycloserine to facilitate NMDA function in humansD'Souza D, Bennett A, Karper L, Gil R, Morrissey K, Abi-Saab D, Charney D, Krystal J. I.V. glycine/d-cycloserine to facilitate NMDA function in humans. Biological Psychiatry 1994, 35: 734. DOI: 10.1016/0006-3223(94)91085-5.
• Soft signs, attention, and startle in schizophreniaKarper L, Grillon C, Lysaker P, Bell M, Charney D, Krystal J. Soft signs, attention, and startle in schizophrenia. Biological Psychiatry 1994, 35: 714. DOI: 10.1016/0006-3223(94)91014-6.
• Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-ReplyKrystal J, Southwick S, Charney D. Alcohol Dependence May Be the Missing Link Between Posttraumatic Stress Disorder and Panic-Reply. JAMA Psychiatry 1994, 51: 430-430. DOI: 10.1001/archpsyc.1994.03950050090014.
• Tryptophan depletion paradigm: Implications for schizophreniaD'Souza D, Gil R, Abi-Dargham A, Karper L, Abi-Saab D, Morrissey K, Brenner L, Charney D, Krystal J. Tryptophan depletion paradigm: Implications for schizophrenia. Biological Psychiatry 1994, 35: 703. DOI: 10.1016/0006-3223(94)90974-1.
• Affective Reactivity of Language in SchizophreniaDOCHERTY N, EVANS I, SLEDGE W, SEIBYL J, KRYSTAL J. Affective Reactivity of Language in Schizophrenia. The Journal Of Nervous And Mental Disease 1994, 182: 98-103. PMID: 8308539, DOI: 10.1097/00005053-199402000-00006.
• Perturbing the Organism: The Biology of Stressful ExperienceD'Souza D, Krystal J. Perturbing the Organism: The Biology of Stressful Experience. The Journal Of Nervous And Mental Disease 1994, 182: 126. DOI: 10.1097/00005053-199402000-00023.
• Clinical Predictors of Self-Mutilation in Hospitalized Forensic PatientsHILLBRAND M, KRYSTAL J, SHARPE K, FOSTER H. Clinical Predictors of Self-Mutilation in Hospitalized Forensic Patients. The Journal Of Nervous And Mental Disease 1994, 182: 9-16. PMID: 8277305, DOI: 10.1097/00005053-199401000-00003.
• Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenilAbi-Dargham A, Seibyl J, Laruelle M, Rattner Z, Zoghbi S, Baldwin R, Ponce Y, Charney D, Hoffer P, Krystal J, Innis R. Spect imaging of the benzodiazepine receptor in humans using [123I]iomazenil. Schizophrenia Research 1993, 9: 191. DOI: 10.1016/0920-9964(93)90389-z.
• The neurological evaluation scale (NES): Factor analysis and clinical correlatesKarper L, Bell M, Lysaker P, Seibyl J, Beam-Goulet J, Brenner L, Krystal J. The neurological evaluation scale (NES): Factor analysis and clinical correlates. Schizophrenia Research 1993, 9: 179. DOI: 10.1016/0920-9964(93)90354-l.
• Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjectsKarper L, Freeman G, Morgan C, Grillon C, Charney D, Krystal J. Pre-pulse inhibition of the acoustic startle response and measures of attention in schizophrenic subjects. Schizophrenia Research 1993, 9: 160. DOI: 10.1016/0920-9964(93)90296-u.
• Ketamine effects reduced by lorazepam in healthy humansKrystal J, Karper L, Abi-Dargham A, Delaney R, Bremmer J, Bowers M, Charney D. Ketamine effects reduced by lorazepam in healthy humans. Schizophrenia Research 1993, 9: 241. DOI: 10.1016/0920-9964(93)90539-u.
• Dose-related effects of the NMDA antagonist, ketamine, in healthy humansKrystal J, Karper L, Seibyl J, Delaney R, Bremner J, Bowers M, Charney D. Dose-related effects of the NMDA antagonist, ketamine, in healthy humans. Schizophrenia Research 1993, 9: 240-241. DOI: 10.1016/0920-9964(93)90538-t.
• Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group TreatmentNAGY L, KRYSTAL J, CHARNEY D, MERIKANGAS K, WOODS S. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment. Journal Of Clinical Psychopharmacology 1993, 13: 16-24. PMID: 8098050, DOI: 10.1097/00004714-199302000-00003.
• Effects of Cocaine on Hospital Course in SchizophreniaSEIBYL J, SATEL S, ANTHONY D, SOUTHWICK S, KRYSTAL J, CHARNEY D. Effects of Cocaine on Hospital Course in Schizophrenia. The Journal Of Nervous And Mental Disease 1993, 181: 31-37. PMID: 8093475, DOI: 10.1097/00005053-199301000-00006.
• Stress, the Aging Brain, and the Mechanisms of Neuron DeathKrystal J. Stress, the Aging Brain, and the Mechanisms of Neuron Death. The Yale Journal Of Biology And Medicine 1993, 66: 109-110. PMCID: PMC2588844.
• Alexithymia as a predictor of treatment response in post-traumatic stress disorderKosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post-traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1007/bf00979225.
• Alexithymia as a predictor of treatment response in post‐traumatic stress disorderKosten T, Krystal J, Giller E, Frank J, Dan E. Alexithymia as a predictor of treatment response in post‐traumatic stress disorder. Journal Of Traumatic Stress 1992, 5: 563-573. DOI: 10.1002/jts.2490050406.
• Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbineKrystal J, McDougle C, Woods S, Price L, Heninger G, Charney D. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine. Psychopharmacology 1992, 108: 313-319. PMID: 1355923, DOI: 10.1007/bf02245117.
• Mazindol and cocaine addiction in schizophreniaSeibyl J, Brenner L, Krystal J, Johnson R, Charney D. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry 1992, 31: 1179-1181. PMID: 1525287, DOI: 10.1016/0006-3223(92)90171-u.
• Valproate Management of Psychosis in a Patient with Carbamazepine-Induced HyponatremiaKARPER L, SEIBYL J, KRYSTAL J. Valproate Management of Psychosis in a Patient with Carbamazepine-Induced Hyponatremia. Journal Of Clinical Psychopharmacology 1992, 12: 137-138. PMID: 1573038, DOI: 10.1097/00004714-199204000-00015.
• Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic DisorderWOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHARNEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Journal Of Clinical Psychopharmacology 1992, 12: 32-38. PMID: 1552038, DOI: 10.1097/00004714-199202000-00006.
• Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder.WOODS S, NAGY L, KOLESZAR A, KRYSTAL J, HENINGER G, CHAEY D. Controlled Trial of Alprazolam Supplementation During Imipramine Treatment of Panic Disorder. Current Opinion In Cardiology 1992, 7: 32. DOI: 10.1097/00001573-199202000-00006.
• Baclofen-assisted detoxification from opiates A pilot studyKrystal J, McDougle C, Kosten T, Price L, Aghajanian G, Charney D. Baclofen-assisted detoxification from opiates A pilot study. Journal Of Substance Abuse Treatment 1992, 9: 139-142. PMID: 1324986, DOI: 10.1016/0740-5472(92)90081-x.
• Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function?Krystal J, Price L, Opsahl C, Ricaurte G, Heninger G. Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use: Effects on Mood and Neuropsychological Function? The American Journal Of Drug And Alcohol Abuse 1992, 18: 331-341. PMID: 1357957, DOI: 10.3109/00952999209026070.
• Invited commentary: complexities in evaluating neurobiological models for stress resistanceKrystal J. Invited commentary: complexities in evaluating neurobiological models for stress resistance. Journal Of Psychopharmacology 1992, 6: 12-14. PMID: 22291236, DOI: 10.1177/026988119200600105.
• Trauma and the Vietnam War GenerationKrystal J. Trauma and the Vietnam War Generation. The Yale Journal Of Biology And Medicine 1992, 65: 543-544. PMCID: PMC2589725.
• Novel Antipsychotic DrugsKrystal J. Novel Antipsychotic Drugs. The Yale Journal Of Biology And Medicine 1992, 65: 539-540. PMCID: PMC2589751.
• Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administrationRasmussen K, Krystal J, Aghajanian G. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology 1991, 105: 508-512. PMID: 1771218, DOI: 10.1007/bf02244371.
• Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacksKrystal J, Woods S, Hill C, Charney D. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks. Comprehensive Psychiatry 1991, 32: 474-480. PMID: 1778074, DOI: 10.1016/0010-440x(91)90026-9.
• Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjectsSeibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.
• Follow-up Study of Patients With Panic Disorder-ReplyNagy L, Krystal J, Charney D, Woods S. Follow-up Study of Patients With Panic Disorder-Reply. JAMA Psychiatry 1991, 48: 861-862. DOI: 10.1001/archpsyc.1991.01810330085018.
• MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatmentKrystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment. Schizophrenia Research 1991, 4: 350. DOI: 10.1016/0920-9964(91)90266-t.
• Elevated central levels of interleukin-2 in drug-free schizophrenic patientsLicinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients. Schizophrenia Research 1991, 4: 372. DOI: 10.1016/0920-9964(91)90301-7.
• Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophreniaDeutch A, Moghaddam B, Innis R, Krystal J, Aghajanian G, Bunney B, Charney D. Mechanisms of action of atypical antipsychotic drugs Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research 1991, 4: 121-156. PMID: 1674882, DOI: 10.1016/0920-9964(91)90030-u.
• Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorderWoods S, Charney D, Silver J, Krystal J, Heninger G. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder. Psychiatry Research 1991, 36: 115-127. PMID: 1850142, DOI: 10.1016/0165-1781(91)90124-8.
• Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary resultsWoods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.
• Serotonin Function and Human Anxiety DisordersaCHARNEY D, WOODS S, KRYSTAL J, HENINGER G. Serotonin Function and Human Anxiety Disordersa. Annals Of The New York Academy Of Sciences 1990, 600: 558-572. PMID: 2252335, DOI: 10.1111/j.1749-6632.1990.tb16910.x.
• Serotonin Function in Panic and Generalized Anxiety DisordersCharney D, Krystal J, Southwick S, Nagy L, Woods S, Heninger G. Serotonin Function in Panic and Generalized Anxiety Disorders. Psychiatric Annals 1990, 20: 593-602. DOI: 10.3928/0048-5713-19901001-11.
• Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlatesRasmussen K, Beitner-Johnson D, Krystal J, Aghajanian G, Nestler E. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. Journal Of Neuroscience 1990, 10: 2308-2317. PMID: 2115910, PMCID: PMC6570391, DOI: 10.1523/jneurosci.10-07-02308.1990.
• Neurobiological Mechanisms of Human AnxietyCharney D, Woods S, Krystal J, Heninger G. Neurobiological Mechanisms of Human Anxiety. 1990, 3: 242-283. DOI: 10.1159/000417680.
• Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-ReplyPrice L, Krystal J, Heninger G, Ricaurte G. Second Thoughts on 3,4-Methylenedioxymethamphetamine (MDMA) Neurotoxicity-Reply. JAMA Psychiatry 1990, 47: 289-289. DOI: 10.1001/archpsyc.1990.01810150089015.
• Opioid antagonist challenges in buprenorphine maintained patientsKosten T, Krystal J, Charney D, Price L, Morgan C, Kleber H. Opioid antagonist challenges in buprenorphine maintained patients. Drug And Alcohol Dependence 1990, 25: 73-78. PMID: 2323312, DOI: 10.1016/0376-8716(90)90144-4.
• Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder?SEIBYL J, KRYSTAL J, CHARNEY D. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal Of Clinical Psychopharmacology 1990, 10: 78. PMID: 2307743, DOI: 10.1097/00004714-199002000-00033.
• Clinical studies of 5-HT function using I.V. l-TryptophanPrice L, Charney D, Delgado P, Goodman W, Krystal J, Woods S, Heninger G. Clinical studies of 5-HT function using I.V. l-Tryptophan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1990, 14: 459-472. PMID: 2236580, DOI: 10.1016/0278-5846(90)90002-x.
• EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTSWoods S, Hegeman I, Krystal J, Smith E, Zubal I, Koster K, Hotfer P. EFFECTS OF VISUAL STIMULATION ON DISTRIBUTION OF TC-99M D, 1 HMPAO IN HEALTHY HUMAN SUBJECTS. Clinical Nuclear Medicine 1989, 14: 230. DOI: 10.1097/00003072-198903000-00025.
• REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDERKoster K, Woods S, Smith E, Zubal I, Krystal J, Charney D, Hoffer P. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER. Clinical Nuclear Medicine 1989, 14: 234. DOI: 10.1097/00003072-198903000-00039.
• Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeysKrystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.
• Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic HypotensionSEIBYL J, KRYSTAL J, PRICE L, CHARNEY D. Use of Yohimbine to Counteract Nortriptyline-Induced Orthostatic Hypotension. Journal Of Clinical Psychopharmacology 1989, 9: 67-68. PMID: 2708559, DOI: 10.1097/00004714-198902000-00026.
• Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjectsWoods S, Krystal J, Heninger G, Charney D. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects. Life Sciences 1989, 45: 233-242. PMID: 2503670, DOI: 10.1016/0024-3205(89)90255-5.
• The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkeyKrystal J, Woods S, Levesque M, Heninger C, Heninger G. The effects of carbon dioxide inhalation of plasma MHPG, plasma hormones respiratory rate, and behavior in the Rhesus monkey. Life Sciences 1989, 45: 1657-1663. PMID: 2511388, DOI: 10.1016/0024-3205(89)90275-0.
• Neurobiological aspects of PTSD: Review of clinical and preclinical studiesKrystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.
• Psychopharmacology: The Third Generation of ProgressKrystal J. Psychopharmacology: The Third Generation of Progress. The Yale Journal Of Biology And Medicine 1989, 62: 554-555. PMCID: PMC2589180.
• Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance AbuseKosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. 1988, 49-68. DOI: 10.1007/978-1-4615-7718-8_3.
• Neural Plasticity. A Lifespan ApproachKrystal J. Neural Plasticity. A Lifespan Approach. The Yale Journal Of Biology And Medicine 1988, 61: 478-479. PMCID: PMC2590436.
• Quantitative Receptor AutoradiographyKrystal J. Quantitative Receptor Autoradiography. The Yale Journal Of Biology And Medicine 1987, 60: 294-295. PMCID: PMC2590106.
• Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and HeartKrystal J. Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart. The Yale Journal Of Biology And Medicine 1987, 60: 202-202. PMCID: PMC2590308.
• Management of alcohol withdrawal in the critically ill patient: a selected review.Krystal H. Management of alcohol withdrawal in the critically ill patient: a selected review. Henry Ford Hospital Medical Journal 1986, 34: 293. PMID: 3583798.
• The Psychopharmacology of LithiumKrystal J. The Psychopharmacology of Lithium. The Yale Journal Of Biology And Medicine 1986, 59: 74-75. PMCID: PMC2590046.
• Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stressvan der Kolk B, Greenberg M, Boyd H, Krystal J. Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post traumatic stress. Biological Psychiatry 1985, 20: 314-325. PMID: 2858226, DOI: 10.1016/0006-3223(85)90061-7.
• Monoamine Innervation of the Cerebral CortexKrystal J. Monoamine Innervation of the Cerebral Cortex. The Yale Journal Of Biology And Medicine 1985, 58: 58-59. PMCID: PMC2589842.
• Behavioral Pharmacology: The Current StatusKrystal J. Behavioral Pharmacology: The Current Status. The Yale Journal Of Biology And Medicine 1985, 58: 197-198. PMCID: PMC2589892.
• Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11Krystal J. Physiology of Adrenocortical Secretion. Frontiers of Hormone Research. Volume 11. The Yale Journal Of Biology And Medicine 1984, 57: 247-247. PMCID: PMC2589820.
• Ethopharmacology: Primate Models of Neuropsychiatric DisordersKrystal J. Ethopharmacology: Primate Models of Neuropsychiatric Disorders. The Yale Journal Of Biology And Medicine 1984, 57: 248-250. PMCID: PMC2589821.
• Anorexia Nervosa: Recent Developments in ResearchKrystal J. Anorexia Nervosa: Recent Developments in Research. The Yale Journal Of Biology And Medicine 1984, 57: 442-443. PMCID: PMC2589855.
• The Natural History of Alcoholism: Causes, Patterns, and Paths to RecoveryKrystal J. The Natural History of Alcoholism: Causes, Patterns, and Paths to Recovery. The Yale Journal Of Biology And Medicine 1983, 56: 339-340. PMCID: PMC2589638.
• Psychopharmacology of ClonidineKrystal J, Arnold R. Psychopharmacology of Clonidine. The Yale Journal Of Biology And Medicine 1982, 55: 543-544. PMCID: PMC2596571.
• Trauma: considerations of its intensity and chronicity.Krystal H. Trauma: considerations of its intensity and chronicity. International Psychiatry Clinics 1971, 8: 11-28. PMID: 5148247.