Research in our lab is directed at determining the molecular pathologies underlying stress disorders such post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and suicidal behavior. We identify therapeutic and biomarker targets relevant to those disorders by utilizing human brain derived data from frozen postmortem tissue. We conduct research focused on the connection between stress and brain functions. My lab employs functional genomics to dissect transcriptomic and cell-type-specific regulatory elements and risk loci underlying the genetics of stress-related mental disorders and engages in translational research using animal models and donor-derived human induced pluripotent stem cells (hiPSCs) to validate causal genes and variants. In addition, my lab employs “big data” approaches to investigate single cell-type molecular dysregulations of complex neuropsychiatric traits to gain a deeper understanding of the individual differences in the expression of symptoms. Together, this work is contributing importantly to the evolving understanding of PTSD and depression and their treatment at the molecular, cellular, and behavioral levels.
While recent large-scale genetic association studies have identified numerous risk loci for PTSD and MDD, the mechanisms through which they contribute to disease remain largely unknown. By applying single cell molecular approaches to the affected tissue (in this case, the human brain), we can uncover novel cellular subpopulations that are associated with these disorders. In parallel, cell type-specific molecular studies allow us to characterize the effect of genetic variation on the complex mechanisms that regulate gene expression in those cells relevant to disease. The goal of our research is to identify causal genes and therapeutic targets relevant to stress-related disorders utilizing human brain derived datasets from frozen postmortem tissue across multiple brain regions and diagnostic groups and couple those with hIPSCs and animal models to understand the neurobiological mechanisms involved.
Current projects include:
Anxiety Disorders; Behavior and Behavior Mechanisms; Genetics; Neurobiology; Neurosciences; Stress Disorders, Post-Traumatic; Stress, Psychological; Suicide; Genomics; Proteomics; Transcriptome