Jason Bini, PhD

• Ania Jastreboff
• David Matuskey
• Elizabeth Sanchez Rangel
• Janice Jin Hwang
• Jean-Dominique Gallezot
• Kathryn Fontaine
• Kelly Cosgrove
• Lisa Parikh
• Maija Cheung
• Michael Kapinos
• Mika Naganawa
• Nabeel Nabulsi
• Richard Carson
• Shivani Bhatt
• Soheila Najafzadeh
• Stephen Strittmatter
• Takuya Toyonaga
• Yiyun Huang

Adipose Tissue; Biomedical Engineering; Brain; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Endocrinology; Liver; Neuroendocrinology; Obesity; Pancreas; Stress, Physiological; Whole Body Imaging; Positron Emission Tomography Computed Tomography

• Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In VivoBini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.
• Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eatingBini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.
• Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PETRossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET EJNMMI Physics 2022, 9: 32. PMID: 35503134, PMCID: PMC9065222, DOI: 10.1186/s40658-022-00464-0.
• The Role of Positron Emission Tomography in Bariatric Surgery Research: a ReviewBini J, Norcross M, Cheung M, Duffy A. The Role of Positron Emission Tomography in Bariatric Surgery Research: a Review Obesity Surgery 2021, 31: 4592-4606. PMID: 34304378, DOI: 10.1007/s11695-021-05576-7.
• Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PETBini J, Lattin CR, Toyonaga T, Finnema SJ, Carson R. Optimized Methodology for Reference Region and Image-Derived Input Function Kinetic Modeling in Preclinical PET IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 454-462. PMID: 36185820, PMCID: PMC9524424, DOI: 10.1109/trpms.2021.3088606.
• Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-JBini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.
• Reply: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 DiabetesBini J, Carson RE, Cline GW. Reply: 11C-(+)-PHNO Trapping Reversibility for Quantitative PET Imaging of β-Cell Mass in Patients with Type 1 Diabetes Journal Of Nuclear Medicine 2020, 61: 1693-1693. PMID: 32620703, DOI: 10.2967/jnumed.120.250985.
• Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography StudyBini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study Molecular Imaging And Biology 2020, 22: 1124-1131. PMID: 32133575, PMCID: PMC7351613, DOI: 10.1007/s11307-020-01490-z.
• PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 DiabetesBini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi N, Lim K, Najafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang Y, Herold K, Harris PE, Sherwin RS, Carson RE, Cline GW. PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes Journal Of Nuclear Medicine 2019, 61: 570-576. PMID: 31601695, PMCID: PMC7198375, DOI: 10.2967/jnumed.119.234013.
• In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer DiseaseToyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease Journal Of Nuclear Medicine 2019, 60: 1780-1786. PMID: 31101744, PMCID: PMC6894376, DOI: 10.2967/jnumed.118.223867.
• Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel WallLobatto ME, Binderup T, Robson PM, Giesen LFP, Calcagno C, Witjes J, Fay F, Baxter S, Wessel CH, Eldib M, Bini J, Carlin SD, Stroes ESG, Storm G, Kjaer A, Lewis JS, Reiner T, Fayad ZA, Mulder WJM, Pérez-Medina C. Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall Bioconjugate Chemistry 2019, 31: 360-368. PMID: 31095372, PMCID: PMC7460274, DOI: 10.1021/acs.bioconjchem.9b00256.
• First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1 Cerebrovascular And Brain Metabolism Reviews 2019, 40: 695-704. PMID: 30895878, PMCID: PMC7168798, DOI: 10.1177/0271678x19838633.
• Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imagingCline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA. Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging Diabetologia 2018, 61: 2598-2607. PMID: 29721633, DOI: 10.1007/s00125-018-4624-0.
• Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western dietRutkowsky JM, Lee LL, Puchowicz M, Golub MS, Befroy DE, Wilson DW, Anderson S, Cline G, Bini J, Borkowski K, Knotts TA, Rutledge JC, . Reduced cognitive function, increased blood-brain-barrier transport and inflammatory responses, and altered brain metabolites in LDLr -/-and C57BL/6 mice fed a western diet PLOS ONE 2018, 13: e0191909. PMID: 29444171, PMCID: PMC5812615, DOI: 10.1371/journal.pone.0191909.
• Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNOBini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE. Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNO Journal Of Nuclear Medicine 2018, 59: 1249-1254. PMID: 29371405, PMCID: PMC6071501, DOI: 10.2967/jnumed.117.197285.
• In Vivo PET Imaging of HDL in Multiple Atherosclerosis ModelsPérez-Medina C, Binderup T, Lobatto ME, Tang J, Calcagno C, Giesen L, Wessel CH, Witjes J, Ishino S, Baxter S, Zhao Y, Ramachandran S, Eldib M, Sánchez-Gaytán BL, Robson PM, Bini J, Granada JF, Fish KM, Stroes ES, Duivenvoorden R, Tsimikas S, Lewis JS, Reiner T, Fuster V, Kjær A, Fisher EA, Fayad ZA, Mulder WJ. In Vivo PET Imaging of HDL in Multiple Atherosclerosis Models JACC Cardiovascular Imaging 2016, 9: 950-961. PMID: 27236528, PMCID: PMC5589956, DOI: 10.1016/j.jcmg.2016.01.020.
• Attenuation Correction for Magnetic Resonance Coils in Combined PET/MR Imaging A ReviewEldib M, Bini J, Faul DD, Oesingmann N, Tsoumpas C, Fayad ZA. Attenuation Correction for Magnetic Resonance Coils in Combined PET/MR Imaging A Review PET Clinics 2015, 11: 151-160. PMID: 26952728, PMCID: PMC4785842, DOI: 10.1016/j.cpet.2015.10.004.
• Feasibility of (18)F-Fluorodeoxyglucose radiotracer dose reduction in simultaneous carotid PET/MR imaging.Eldib M, Bini J, Lairez O, Faul DD, Oesingmann N, Fayad ZA, Mani V. Feasibility of (18)F-Fluorodeoxyglucose radiotracer dose reduction in simultaneous carotid PET/MR imaging. Am J Nucl Med Mol Imaging 2015, 5: 401-7. PMID: 26269777, PMCID: PMC4529593.
• Markerless attenuation correction for carotid MRI surface receiver coils in combined PET/MR imagingEldib M, Bini J, Robson PM, Calcagno C, Faul DD, Tsoumpas C, Fayad ZA. Markerless attenuation correction for carotid MRI surface receiver coils in combined PET/MR imaging Physics In Medicine And Biology 2015, 60: 4705-4717. PMID: 26020273, PMCID: PMC4495953, DOI: 10.1088/0031-9155/60/12/4705.
• Simultaneous carotid PET/MR: feasibility and improvement of magnetic resonance-based attenuation correctionBini J, Eldib M, Robson PM, Calcagno C, Fayad ZA. Simultaneous carotid PET/MR: feasibility and improvement of magnetic resonance-based attenuation correction The International Journal Of Cardiovascular Imaging 2015, 32: 61-71. PMID: 25898892, PMCID: PMC4618272, DOI: 10.1007/s10554-015-0661-7.
• Quantitative carotid PET/MR imaging: clinical evaluation of MR-Attenuation correction versus CT-Attenuation correction in (18)F-FDG PET/MR emission data and comparison to PET/CT.Bini J, Robson PM, Calcagno C, Eldib M, Fayad ZA. Quantitative carotid PET/MR imaging: clinical evaluation of MR-Attenuation correction versus CT-Attenuation correction in (18)F-FDG PET/MR emission data and comparison to PET/CT. Am J Nucl Med Mol Imaging 2015, 5: 293-304. PMID: 26069863, PMCID: PMC4446398.
• Quantitative carotid MR/PET imaging: comprehensive comparison of MRAC and CTAC attenuation maps in MR/PET emission data and PET/CTBini J, Robson PM, Calgano C, Eldib M, Fayad ZA. Quantitative carotid MR/PET imaging: comprehensive comparison of MRAC and CTAC attenuation maps in MR/PET emission data and PET/CT EJNMMI Physics 2014, 1: a70. PMID: 26501661, PMCID: PMC4545463, DOI: 10.1186/2197-7364-1-s1-a70.
• Wavelet-based partial volume effect correction for simultaneous MR/PET of the carotid arteriesBini J, Eldib M, Robson PM, Fayad ZA. Wavelet-based partial volume effect correction for simultaneous MR/PET of the carotid arteries EJNMMI Physics 2014, 1: a71. PMID: 26501662, PMCID: PMC4545959, DOI: 10.1186/2197-7364-1-s1-a71.
• Attenuation Correction for Flexible Magnetic Resonance Coils in Combined Magnetic Resonance/Positron Emission Tomography ImagingEldib M, Bini J, Calcagno C, Robson PM, Mani V, Fayad ZA. Attenuation Correction for Flexible Magnetic Resonance Coils in Combined Magnetic Resonance/Positron Emission Tomography Imaging Investigative Radiology 2014, 49: 63-69. PMID: 24056110, PMCID: PMC4011564, DOI: 10.1097/rli.0b013e3182a530f8.
• Improvement of Attenuation Correction in Time-of-Flight PET/MR Imaging with a Positron-Emitting SourceMollet P, Keereman V, Bini J, Izquierdo-Garcia D, Fayad ZA, Vandenberghe S. Improvement of Attenuation Correction in Time-of-Flight PET/MR Imaging with a Positron-Emitting Source Journal Of Nuclear Medicine 2014, 55: 329-336. PMID: 24434291, PMCID: PMC4010111, DOI: 10.2967/jnumed.113.125989.
• Preclinical Evaluation of MR Attenuation Correction Versus CT Attenuation Correction on a Sequential Whole-Body MR/PET ScannerBini J, Izquierdo-Garcia D, Mateo J, Machac J, Narula J, Fuster V, Fayad ZA. Preclinical Evaluation of MR Attenuation Correction Versus CT Attenuation Correction on a Sequential Whole-Body MR/PET Scanner Investigative Radiology 2013, 48: 313-322. PMID: 23296082, PMCID: PMC3638002, DOI: 10.1097/rli.0b013e31827a49ba.
• Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scannerMillon A, Dickson S, Klink A, Izquierdo-Garcia D, Bini J, Lancelot E, Ballet S, Robert P, de Castro J, Corot C, Fayad Z. Monitoring plaque inflammation in atherosclerotic rabbits with an iron oxide (P904) and 18F-FDG using a combined PET/MR scanner Atherosclerosis 2013, 228: 339-345. PMID: 23582588, PMCID: PMC4128694, DOI: 10.1016/j.atherosclerosis.2013.03.019.
• Radial k-space Acquisition Improves Robustness of MR-based Attenuation Maps for MR/PET Quantification in an Animal Imaging Study of the AbdomenBini J, Robson P, Calcagno C, Millon A, Lobatto M, Fayad Z. Radial k-space Acquisition Improves Robustness of MR-based Attenuation Maps for MR/PET Quantification in an Animal Imaging Study of the Abdomen 2012, 1-6. DOI: 10.1109/spmb.2012.6469451.
• Confocal mosaicing microscopy of human skin ex vivo: spectral analysis for digital staining to simulate histology-like appearanceBini J, Spain J, Nehal K, Hazelwood V, DiMarzio C, Rajadhyaksha M. Confocal mosaicing microscopy of human skin ex vivo: spectral analysis for digital staining to simulate histology-like appearance Journal Of Biomedical Optics 2011, 16: 076008-076008-8. PMID: 21806269, PMCID: PMC3154052, DOI: 10.1117/1.3596742.
• Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary Neuroendocrine CarcinomasBusam KJ, Jungbluth AA, Rekthman N, Coit D, Pulitzer M, Bini J, Arora R, Hanson NC, Tassello JA, Frosina D, Moore P, Chang Y. Merkel Cell Polyomavirus Expression in Merkel Cell Carcinomas and Its Absence in Combined Tumors and Pulmonary Neuroendocrine Carcinomas The American Journal Of Surgical Pathology 2009, 33: 1378-1385. PMID: 19609205, PMCID: PMC2932664, DOI: 10.1097/pas.0b013e3181aa30a5.