Kelly Cosgrove, PhD
Professor of Psychiatry and of Neuroscience and of Radiology and Biomedical Imaging; Co-Director of the T32 Translational Alcohol Research Program, Psychiatry and Public Health
Research & Publications
Biography
News
Locations
Research Summary
We are using novel, creative PET paradigms to gain insight into the neurochemical mechanisms that drive and promote the recovery from addiction and psychiatric disorders. PET allows us to measure specific molecules in the living human brain. We are particularly interested in identifying deficits in the cholinergic, dopaminergic, and glutamatergic neurotransmitter systems and in the neuroimmune system in people who drink and use drugs and how these systems change during recovery. We are uncovering variables such as stress, sex, neurocognitive function, mood, and psychiatric status that influence these changes. We are also examining the neuroadaptations that occur in individuals with PTSD including changes in epigenetics, and in the glucocorticoid and neuroimmune systems. In addition to PET, we incorporate structural and functional MRI in our studies and we are developing and performing dual-tracer and multi-modal analyses to fully leverage our data sets.
Specialized Terms: Positron Emission Tomography; Neuroimaging; Alcohol Use Disorder; Tobacco Smoking; Opioid Use Disorder; Posttraumatic Stress Disorder; Brain; nicotinic acetylcholine receptor; Glutamate; Sex differences, Dopamine; Neuroimmune; Synaptic Plasticity
Extensive Research Description
- Understanding the functional basis and behavioral and cognitive correlates of the changes in beta2*-nicotinic acetylcholine receptor availability during acute and prolonged abstinence in tobacco smokers.
- Examining the changes in mglu5 receptor availability that occur during acute and prolonged abstinence from alcohol and nicotine dependence.
- Radiotracer development targeted at the stress and glucocorticoid systems.
- Examination of sex differences in the dopaminergic signature of smoking- and nicotine-induced dopamine release using novel PET brain imaging techniques.
- Examining effects of chronic alcohol consumption on the neuroimmune system and relationships to synaptic plasticity in living humans with alcohol use disorder.
- Examining the stress and neuroimmune system with PET and the application to psychiatric disorders such as PTSD.
- Measuring the neuroimmune state of the brain in individuals with opioid use disorder during early recovery.
Coauthors
Research Interests
Alcohol Drinking; Brain; Opioid-Related Disorders; Neurobiology; Nicotine; Radiology; Positron-Emission Tomography; Neuroimaging; alpha7 Nicotinic Acetylcholine Receptor; Diseases; Chemicals and Drugs; Psychiatry and Psychology
Selected Publications
- Clustering of KOR PET images separates people with AUD into distinct responses to naltrexoneHoye J, Key J, de Laat B, Cosgrove K, Krishnan-Sarin S, Papademetris X, Morris E. Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone Brain Imaging And Behavior 2023, 1-5. PMID: 36695971, DOI: 10.1007/s11682-023-00758-6.
- Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[18F]flubatine PET studyCalakos K, Hillmer A, Anderson J, LeVasseur B, Baldassarri S, Angarita G, Matuskey D, Kapinos M, Zheng M, Huang Y, Cosgrove K. Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[18F]flubatine PET study Neuropsychopharmacology 2023, 48: 683-689. PMID: 36681758, PMCID: PMC9938267, DOI: 10.1038/s41386-023-01535-1.
- Lower dopamine D2/3 receptor availability is associated with worse verbal learning and memory in people who smoke cigarettes.Zakiniaeiz Y, Gueorguieva R, Peltier M, Roberts W, Verplaetse T, Burke C, Morris E, McKee S, Cosgrove K. Lower dopamine D2/3 receptor availability is associated with worse verbal learning and memory in people who smoke cigarettes. Nicotine & Tobacco Research 2022 PMID: 36107715, DOI: 10.1093/ntr/ntac215.
- Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokersZakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, DOI: 10.1016/j.bbi.2022.08.016.
- Why language matters in alcohol research: Reducing stigmaShi HD, McKee SA, Cosgrove KP. Why language matters in alcohol research: Reducing stigma Alcoholism Clinical And Experimental Research 2022, 46: 1103-1109. PMID: 35727299, PMCID: PMC9246863, DOI: 10.1111/acer.14840.
- P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSDHillmer A, Davis M, Esterlis I, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. P646. Combining Neuroimaging α7 Nicotinic Acetylcholine Receptors and Peripheral Immune Markers in People With PTSD Biological Psychiatry 2022, 91: s351. DOI: 10.1016/j.biopsych.2022.02.883.
- Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorderSmart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder Alcoholism Clinical And Experimental Research 2022, 46: 770-782. PMID: 35342968, PMCID: PMC9117461, DOI: 10.1111/acer.14816.
- A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMCID: PMC9669946, DOI: 10.1159/000524079.
- A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi R, Girgenti M, Krystal J, Cosgrove K. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here? Complex Psychiatry 2022, 8: 13-27. PMID: 36545044, PMCID: PMC9669946, DOI: 10.1159/000524079.
- Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment responseZakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment response Nicotine & Tobacco Research 2022, 24: ntac026-. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.
- Relationships between dopamine D2/3 receptor availability and social-environmental factors in humansCalakos KC, Rusowicz A, Pittman B, Gallezot JD, Potenza MN, Cosgrove KP, Matuskey D. Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans Neuroscience Letters 2022, 771: 136463. PMID: 35051435, PMCID: PMC8821418, DOI: 10.1016/j.neulet.2022.136463.
- Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1 Journal Of Clinical Investigation 2021, 131: e150452. PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/jci150452.
- Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study. Nicotine & Tobacco Research 2021, 24: 745-752. PMID: 34628508, PMCID: PMC8962719, DOI: 10.1093/ntr/ntab208.
- Assessment of transient dopamine responses to smoked cannabisCalakos KC, Liu H, Lu Y, Anderson JM, Matuskey D, Nabulsi N, Ye Y, Skosnik PD, D'Souza DC, Morris ED, Cosgrove KP, Hillmer AT. Assessment of transient dopamine responses to smoked cannabis Drug And Alcohol Dependence 2021, 227: 108920. PMID: 34399137, PMCID: PMC8464527, DOI: 10.1016/j.drugalcdep.2021.108920.
- Morphine Induces a Neuroimmune Response in Healthy Volunteers: Implications for Opioid Use DisorderWoodcock E, Angarita G, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Hillmer A, Carson R, Cosgrove K. Morphine Induces a Neuroimmune Response in Healthy Volunteers: Implications for Opioid Use Disorder Biological Psychiatry 2021, 89: s252-s253. DOI: 10.1016/j.biopsych.2021.02.632.
- Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) StudyNia A, D'Souza C, Cosgrove K, Pietrzak R, Harpaz-Rotem I. Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study Biological Psychiatry 2021, 89: s328-s329. DOI: 10.1016/j.biopsych.2021.02.820.
- Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disordersPeltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.
- PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain. Cerebral Cortex 2021, 31: 2787-2798. PMID: 33442731, PMCID: PMC8355478, DOI: 10.1093/cercor/bhaa387.
- PBR28 Brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s diseaseSalardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. PBR28 Brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037792.
- 11C‐PBR28 brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s diseaseSalardini A, Hillmer A, Mecca A, Hashemi‐Aghdam A, Laltoo E, Savoia S, O'Dell R, Harris J, Godek T, Nabulsi N, Lim K, Ropchan J, Huang Y, Cosgrove K, Carson R, Strittmatter S, van Dyck C. 11C‐PBR28 brain PET imaging with lipopolysaccharide challenge for the study of microglia function in Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043584.
- Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging studyWoodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH. Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study Brain Behavior And Immunity 2020, 91: 784-787. PMID: 33002632, PMCID: PMC7749814, DOI: 10.1016/j.bbi.2020.09.027.
- Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinenceHillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley S, Cosgrove KP. Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence Neuropsychopharmacology 2020, 46: 380-385. PMID: 32919411, PMCID: PMC7852514, DOI: 10.1038/s41386-020-00856-9.
- PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studiesBhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
- Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) StudyNia A, D'Souza C, Cosgrove K, Pietrzak R, Harpaz-Rotem I. Differential Effects of Childhood Vs. Adulthood Trauma in Cannabinoid Receptor Type 1 (CB1R) Availability in Post-Traumatic Stress Disorder (PTSD): A Review of Literature and Pilot Positron Emission Tomography (PET) Study Biological Psychiatry 2020, 87: s381. DOI: 10.1016/j.biopsych.2020.02.976.
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 yearsVerplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years Journal Of Neuroscience Research 2020, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.
- Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET StudyHillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study Journal Of Nuclear Medicine 2020, 61: 1200-1204. PMID: 32005773, PMCID: PMC7413239, DOI: 10.2967/jnumed.119.237735.
- Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokersZakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers Neuropsychopharmacology 2019, 44: 2205-2211. PMID: 31269510, PMCID: PMC6897943, DOI: 10.1038/s41386-019-0456-y.
- F33. In Vivo Brain Imaging of 11beta-Hydroxysteroid Dehydrogenase, a Marker of Cortisol Production, in PTSDBhatt S, Matuskey D, Rusowicz A, Southwick S, Carson R, Hillmer A, Huang H, Cosgrove K. F33. In Vivo Brain Imaging of 11beta-Hydroxysteroid Dehydrogenase, a Marker of Cortisol Production, in PTSD Biological Psychiatry 2019, 85: s225. DOI: 10.1016/j.biopsych.2019.03.570.
- First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1 Cerebrovascular And Brain Metabolism Reviews 2019, 40: 695-704. PMID: 30895878, PMCID: PMC7168798, DOI: 10.1177/0271678x19838633.
- F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSDHillmer A, Esterlis I, Davis M, Matuskey D, Huang H, Carson R, Krystal J, Cosgrove K. F3. Imaging Alpha7 Nicotinic Acetylcholine Receptors in Individuals With PTSD Biological Psychiatry 2018, 83: s237-s238. DOI: 10.1016/j.biopsych.2018.02.616.
- Author Correction: Mechanisms Underlying Sex Differences in Cannabis UseCalakos K, Bhatt S, Foster D, Cosgrove K. Author Correction: Mechanisms Underlying Sex Differences in Cannabis Use Current Addiction Reports 2017, 4: 454-454. DOI: 10.1007/s40429-017-0179-2.
- The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET StudySandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [11C]FLB457 PET Study Neuropsychopharmacology 2017, 43: 1052-1058. PMID: 28944773, PMCID: PMC5854798, DOI: 10.1038/npp.2017.223.
- In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependenceHillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence Molecular Psychiatry 2017, 22: 1759-1766. PMID: 28242869, PMCID: PMC5573660, DOI: 10.1038/mp.2017.10.
- Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol AbstinenceHillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence Alcoholism Clinical And Experimental Research 2016, 40: 698-705. PMID: 26971694, PMCID: PMC4983773, DOI: 10.1111/acer.12997.
- Imaging robust microglial activation after lipopolysaccharide administration in humans with PETSandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O’Connor K, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 12468-12473. PMID: 26385967, PMCID: PMC4603509, DOI: 10.1073/pnas.1511003112.
- Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawalCosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O’Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 18031-18036. PMID: 25453062, PMCID: PMC4273348, DOI: 10.1073/pnas.1413947111.
- Sex Differences in the Brain's Dopamine Signature of Cigarette SmokingCosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking Journal Of Neuroscience 2014, 34: 16851-16855. PMID: 25505336, PMCID: PMC4261105, DOI: 10.1523/jneurosci.3661-14.2014.
- How to Study Smoking and Drinking with PETMorris E, Lucas M, Cosgrove K. How to Study Smoking and Drinking with PET 2013 DOI: 10.5772/57414.
- Imaging Nicotine- and Amphetamine-Induced Dopamine Release in Rhesus Monkeys with [11C]PHNO vs [11C]raclopride PETGallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED, Cosgrove KP. Imaging Nicotine- and Amphetamine-Induced Dopamine Release in Rhesus Monkeys with [11C]PHNO vs [11C]raclopride PET Neuropsychopharmacology 2013, 39: 866-874. PMID: 24220025, PMCID: PMC3924521, DOI: 10.1038/npp.2013.286.
- Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette SmokingMorris E, Kim S, Sullivan J, Wang S, Normandin M, Constantinescu C, Cosgrove K. Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking Journal Of Visualized Experiments 2013 DOI: 10.3791/50358-v.
- Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primatesHannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP. Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates NeuroImage 2012, 63: 232-239. PMID: 22776451, PMCID: PMC3699786, DOI: 10.1016/j.neuroimage.2012.06.055.
- Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco SmokersCosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O’Malley S. Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers JAMA Psychiatry 2012, 69: 418-427. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.
- The Relationship Between Mood, Stress, and Tobacco SmokingWalderhaug E, Cosgrove K, Bhagwagar Z, Neumeister A. The Relationship Between Mood, Stress, and Tobacco Smoking 2010, 147-161. DOI: 10.1007/978-1-4419-6373-4_10.
- Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PETCosgrove K, Gallezot J, Weinzimmer D, Fowles K, Labaree D, Zheng M, Lim K, Carson R, Morris E. Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PET NeuroImage 2010, 52: s79. DOI: 10.1016/j.neuroimage.2010.04.063.
- Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scannerGallezot J, Weinzimmer D, Fowles K, Labaree D, Cosgrove K, Ding Y, Morris E, Carson R. Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scanner NeuroImage 2010, 52: s173. DOI: 10.1016/j.neuroimage.2010.04.141.
- β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco SmokingCosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O’Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK. β2-Nicotinic Acetylcholine Receptor Availability During Acute and Prolonged Abstinence From Tobacco Smoking JAMA Psychiatry 2009, 66: 666-676. PMID: 19487632, PMCID: PMC2796827, DOI: 10.1001/archgenpsychiatry.2009.41.
- 6‐[123I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D4 receptor: synthesis and in vivo evaluation in a nonhuman primateAlagille D, Koren A, Kudej G, Staley J, Cosgrove K, Seibyl J, Tamagnan G. 6‐[123I]Iodo‐2‐[[4‐(2‐methoxyphenyl) piperazin‐1‐yl]methyl]imidazo[1,2‐a]pyridine as potential SPECT agent for imaging dopamine D4 receptor: synthesis and in vivo evaluation in a nonhuman primate Journal Of Labelled Compounds And Radiopharmaceuticals 2008, 51: 202-206. DOI: 10.1002/jlcr.1500.
- SPECT imaging of [123I]5-IA-85380 binding to beta2-nicotinic acetylcholine receptors in healthy smokers: Assessment of nondisplaceable uptakeBatis J, Esterlis I, Bois F, Cosgrove K, Stiklus S, Kloczynski T, McKee S, Jatlow P, O'Malley S, Seibyl J, Tamagnan G, Van Dyck C, Staley J. SPECT imaging of [123I]5-IA-85380 binding to beta2-nicotinic acetylcholine receptors in healthy smokers: Assessment of nondisplaceable uptake NeuroImage 2008, 41: t175. DOI: 10.1016/j.neuroimage.2008.04.142.
- Single nucleotide polymorphisms of ANKK1 and CHRNA4: Influence on nicotinic acetylcholine receptor availability in nonsmokers measured using [123I]5-IA-85380 SPECTBatis J, Yang B, Cosgrove K, Bois F, Esterlis I, Stiklus S, Kloczynski T, Perry E, Seibyl J, Tamagnan G, Van Dyck C, Gelernter J, Staley J. Single nucleotide polymorphisms of ANKK1 and CHRNA4: Influence on nicotinic acetylcholine receptor availability in nonsmokers measured using [123I]5-IA-85380 SPECT NeuroImage 2008, 41: t174. DOI: 10.1016/j.neuroimage.2008.04.141.
- Evolving Knowledge of Sex Differences in Brain Structure, Function, and ChemistryCosgrove KP, Mazure CM, Staley JK. Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry Biological Psychiatry 2007, 62: 847-855. PMID: 17544382, PMCID: PMC2711771, DOI: 10.1016/j.biopsych.2007.03.001.
- Human Tobacco Smokers in Early Abstinence Have Higher Levels of β2* Nicotinic Acetylcholine Receptors than NonsmokersStaley JK, Krishnan-Sarin S, Cosgrove KP, Krantzler E, Frohlich E, Perry E, Dubin JA, Estok K, Brenner E, Baldwin RM, Tamagnan GD, Seibyl JP, Jatlow P, Picciotto MR, London ED, O'Malley S, van Dyck CH. Human Tobacco Smokers in Early Abstinence Have Higher Levels of β2* Nicotinic Acetylcholine Receptors than Nonsmokers Journal Of Neuroscience 2006, 26: 8707-8714. PMID: 16928859, PMCID: PMC6674379, DOI: 10.1523/jneurosci.0546-06.2006.
- [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokersStaley J, Tellioglu T, Bois F, Palazzo C, McGuire-Schwartz N, Cosgrove K, van Dyck C, Tamagnan G, Seibyl J, Krystal J, D'Souza D. [I-123] 5-IA-85380 SPECT imaging of beta2-nicotinic acetylcholine receptors in recently abstinent mentally healthy and schizophrenic smokers NeuroImage 2006, 31: t154. DOI: 10.1016/j.neuroimage.2006.04.137.
- INER, a subnanomolar affinity ligand for the norepinephrine transporter: In vivo characterization in subhuman primatesTamagnan G, Koren A, Staley J, Cosgrove K, Megyola C, Marek K, Seibyl J. INER, a subnanomolar affinity ligand for the norepinephrine transporter: In vivo characterization in subhuman primates NeuroImage 2006, 31: t137. DOI: 10.1016/j.neuroimage.2006.04.121.
- Longitudinal assessment of beta2-nicotinic acetylcholine receptor availability in abstinent smokers: A [I-123]5-IA-85380 SPECT imaging studyCosgrove K, Frohlich E, Krishnan-Sarin S, O'Malley S, Bois F, Tamagnan G, Seibyl J, Staley J. Longitudinal assessment of beta2-nicotinic acetylcholine receptor availability in abstinent smokers: A [I-123]5-IA-85380 SPECT imaging study NeuroImage 2006, 31: t155. DOI: 10.1016/j.neuroimage.2006.04.138.
- Reductions in ethanol, phencyclidine, and food-maintained behavior by naltrexone pretreatment in monkeys is enhanced by open economic conditionsCarroll M, Cosgrove K, Campbell U, Morgan A, Mickelberg J. Reductions in ethanol, phencyclidine, and food-maintained behavior by naltrexone pretreatment in monkeys is enhanced by open economic conditions Psychopharmacology 2000, 148: 412-422. PMID: 10928315, DOI: 10.1007/s002130050071.
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