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Richard Carson, PhD

Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Director of Graduate Studies, Biomedical Engineering

Research & Publications
Biography
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Research Summary

Dr. Richard Carson's research uses Positron Emission Tomography (PET) as a tool to noninvasively measure a wide range of in vivo physiology in human beings and laboratory animals. His focus is on the development and applications of new tracer kinetic modeling methods and algorithms and on research in PET image reconstruction and image quantification. These quantitative techniques are then applied in clinical populations and preclinical models of disease. Application areas include neuropsychiatric populations, diabetes, cardiology, and oncology. A primary focus of his biological and clinical applications is the measurement of synaptic density in a wide range of neuropsychiatric disorders. In addition, Dr. Carson is leading a BRAIN initiative grant to build a state-of-the-art dedicated brain PET system with unparalleled resolution and sensitivity.

Specialized Terms: Positron emission tomography (PET) modeling and physics; Tracer kinetic modeling methods and parametric imaging techniques for PET tracers; Application of receptors ligands to assess neurotransmitter dynamic; 3D and 4D PET image reconstruction; Medical imaging

Extensive Research Description

Following administration of a positron-emitting radiopharmaceutical (tracer), PET permits the direct measurement of the four-dimensional radioactivity profile throughout a 3D object over time. Depending on the characteristics of the tracer, physiological parameters can be estimated, such as blood flow, metabolism, and receptor concentration. These measurements can be made with subjects in different states (e.g., stimulus or drug activation), used to compare patient groups to controls, or to assess the efficacy of drug treatment.

Tracer Kinetic Modeling

The goal of PET tracer kinetic modeling is to devise a biologically validated, quantitatively reliable, and logistically practical method for use in human PET studies. Animal studies are typically performed to characterize the tracers, followed by initially complex human studies, typically leading to the development of simplified methods, e.g., using continuous tracer infusion. These techniques are also applied on a pixel-by-pixel level to produce images of PET physiological and pharmacological parameters, such as blood flow and receptor binding. Mathematical methodology includes linear and non-linear differential equations, statistical estimation theory, methods to avoid the needs for arterial blood measurements (the input function) such as blind deconvolution, plus the development of novel rapid computational algorithms.

PET Physics and Reconstruction.

Proper characterization of the PET image data is essential for modeling studies. This requires accurate and carefully characterized corrections for the physics and electronics of coincident event acquisition. Studies of these effects are performed with phantom measurements made on the scanner.

A critical component in the application to real data is the correction for subject motion, particularly as the resolution of modern machines has improved (better than 3-mm in human brain machines). Both hardware and software approaches are employed to address these issues. To produce accurate images with minimum noise, a statistically-based iterative reconstruction algorithm is necessary. Developments in this area include the mathematical aspects of algorithm development, the computer science issues associated with a large cluster-based algorithm, the incorporation of the physics and motion correction, the use of prior information provided from MR images, and the tuning and characterization necessary for practical application for biological studies. The ultimate goal is the combination of the tracer kinetic modeling and image reconstruction to directly process a 4D dataset into parametric images of the physiological parameters of interest. When applied in the thorax, respiratory and cardiac motion must be included, raising the problem to 5D and 6D analysis.

These issue are now all being taken to the next level for the building and optimization of the NeuroEXPLORER (a.k.a. NX), which will have 10-fold higher sensitivity than the previous state-of-the-art HRRT. This system, scheduled to arrive at Yale early in 2023 will open new vista for brain PET investigations.

PET Applications

PET studies are performed in human subjects and preclinical models of a wide variety of diseases. Examples of interest include:

Develop the highest resolution and sensitivity human brain PET system (U01EB029811)
Synaptic density imaging in the living human brain (See Science Translational Medicine, 2016 and subsequent clinical and preclinical paper)
Measuring beta cells in the pancreas for diabetes with novel tracers including ligands for the vesicular monoamine transporter
Using PET to measure drug delivery in cancer
Neuroreceptor studies have focused on determining changes in receptor concentration as a function of disease or measurement of receptor occupancy by drugs. Such changes have been successfully demonstrated in the dopaminergic, muscarinic, and serotonergic systems.
Measurement of the relationship between dopamine receptors and impulsivity
New methods for quantification of myocardial blood flow
Hypoxia assessment in tumors before and after radiation treatment
Differentiation of radiation necrosis vs. tumor recurrence

4D/5D Image reconstruction for PET
Mathematical model development for novel radiopharmaceuticals
Imaging of beta cells in the pancreas
Neuroinflammation imaging in a wide variety of disorders
Novel preclinical and clinical applications in oncology

Coauthors

Research Interests

Biomedical Engineering; Nuclear Medicine; Physiology; Radiology; Positron-Emission Tomography

Research Images

SynapticDensityImaging_SciTranslMed_cover

Our work on synaptic density imaging was published in Science Translational Medicine on July 20, 2016

Selected Publications

EM reconstruction algorithms for emission and transmission tomography.Lange K, Carson R. EM reconstruction algorithms for emission and transmission tomography. Journal Of Computer Assisted Tomography 1984, 8: 306-16. PMID: 6608535.
Imaging synaptic density in the living human brainFinnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain. Science Translational Medicine 2016, 8: 348ra96. PMID: 27440727, DOI: 10.1126/scitranslmed.aaf6667.
Consensus Nomenclature for in vivo Imaging of Reversibly Binding RadioligandsInnis RB, Cunningham VJ, Delforge J, Fujita M, Gjedde A, Gunn RN, Holden J, Houle S, Huang SC, Ichise M, Iida H, Ito H, Kimura Y, Koeppe RA, Knudsen GM, Knuuti J, Lammertsma AA, Laruelle M, Logan J, Maguire RP, Mintun MA, Morris ED, Parsey R, Price JC, Slifstein M, Sossi V, Suhara T, Votaw JR, Wong DF, Carson RE. Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands. Cerebrovascular And Brain Metabolism Reviews 2007, 27: 1533-1539. PMID: 17519979, DOI: 10.1038/sj.jcbfm.9600493.
First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2ANaganawa M, Li S, Nabulsi N, Henry S, Zheng MQ, Pracitto R, Cai Z, Gao H, Kapinos M, Labaree D, Matuskey D, Huang Y, Carson RE. First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A. Journal Of Nuclear Medicine 2020, 62: 561-567. PMID: 32859701, PMCID: PMC8049363, DOI: 10.2967/jnumed.120.249144.
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic ImagingChen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography studyFinnema SJ, Toyonaga T, Detyniecki K, Chen M, Dias M, Wang Q, Lin S, Naganawa M, Gallezot J, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study. Epilepsia 2020, 61: 2183-2193. PMID: 32944949, DOI: 10.1111/epi.16653.
Lower synaptic density is associated with depression severity and network alterationsHolmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.
Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional ImagingWu Y, Carson RE. Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional Imaging. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1440-1452. PMID: 12468889, DOI: 10.1097/01.wcb.0000033967.83623.34.
Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission TomographyCarson R, Channing M, Blasberg R, Dunn B, Cohen R, Rice K, Herscovitch P. Comparison of Bolus and Infusion Methods for Receptor Quantitation: Application to [18F]Cyclofoxy and Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 24-42. PMID: 8380178, DOI: 10.1038/jcbfm.1993.6.
Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous InfusionCarson R, Breier* A, de Bartolomeis* A, Saunders† R, Su* T, Schmall B, Der M, Pickar* D, Eckelman W. Quantification of Amphetamine-Induced Changes in [11C] Raclopride Binding with Continuous Infusion. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 437-447. PMID: 9143226, DOI: 10.1097/00004647-199704000-00009.
Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET.Asch R, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson R. Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET. Cerebrovascular And Brain Metabolism Reviews 2023, 271678x231200423. PMID: 37669455, DOI: 10.1177/0271678x231200423.
Synaptic PET Imaging in NeurodegenerationChen M, Matuskey D, Finnema S, Carson R. Synaptic PET Imaging in Neurodegeneration. 2023, 157-167. DOI: 10.1007/978-3-031-35098-6_10.
PET Quantification and Kinetic AnalysisCarson R, Naganawa M, Gallezot J. PET Quantification and Kinetic Analysis. 2023, 183-194. DOI: 10.1007/978-3-031-35098-6_12.
Improving SUVR quantification by correcting for radiotracer clearance in tissue.Honhar P, Matuskey D, Carson R, Hillmer A. Improving SUVR quantification by correcting for radiotracer clearance in tissue. Cerebrovascular And Brain Metabolism Reviews 2023, 271678x231196804. PMID: 37589538, DOI: 10.1177/0271678x231196804.
Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DTI and SV2A PETSilva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Varma P, Toyonaga T, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DTI and SV2A PET. American Journal Of Geriatric Psychiatry 2023 PMID: 37673749, DOI: 10.1016/j.jagp.2023.08.002.
Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission TomographyRaval N, Angarita G, Matuskey D, Miller R, Drake L, Kapinos M, Nabulsi N, Huang Y, Carson R, O’Malley S, Cosgrove K, Hillmer A. Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography. Molecular Psychiatry 2023, 1-7. PMID: 37532797, DOI: 10.1038/s41380-023-02198-6.
Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DTI and SV2A PETSilva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Varma P, Toyonaga T, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's disease: A multimodal imaging study with DTI and SV2A PET. American Journal Of Geriatric Psychiatry 2023 DOI: 10.1016/j.jagp.2023.08.002.
Relationships of in vivo brain norepinephrine transporter and age, BMI, and genderKoohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.
Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 39: 103457. PMID: 37422964, PMCID: PMC10338149, DOI: 10.1016/j.nicl.2023.103457.
Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 103457. DOI: 10.1016/j.nicl.2023.103457.
Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primatesChen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.
Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET studyFang X, Volpi T, Holmes S, Esterlis I, Carson R, Worhunsky P. Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET study. Frontiers In Human Neuroscience 2023, 17: 1124254. PMCID: PMC9995441, DOI: 10.3389/fnhum.2023.1124254.
Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET studyFang X, Volpi T, Holmes S, Esterlis I, Carson R, Worhunsky P. Linking resting-state network fluctuations with systems of coherent synaptic density: A multimodal fMRI and 11C-UCB-J PET study. Frontiers In Human Neuroscience 2023, 17: 1124254. PMID: 36908710, PMCID: PMC9995441, DOI: 10.3389/fnhum.2023.1124254.
Reductions in synaptic marker SV2A in early-course SchizophreniaYoon J, Zhang Z, Mormino E, Davidzon G, Minzenberg M, Ballon J, Kalinowski A, Hardy K, Naganawa M, Carson R, Khalighi M, Park J, Levinson D, Chin F. Reductions in synaptic marker SV2A in early-course Schizophrenia. Journal Of Psychiatric Research 2023, 161: 213-217. PMID: 36934603, DOI: 10.1016/j.jpsychires.2023.02.026.
Generation of Whole-Body FDG Parametric Ki Images From Static PET Images Using Deep LearningMiao T, Zhou B, Liu J, Guo X, Liu Q, Xie H, Chen X, Chen M, Wu J, Carson R, Liu C. Generation of Whole-Body FDG Parametric Ki Images From Static PET Images Using Deep Learning. IEEE Transactions On Radiation And Plasma Medical Sciences 2023, 7: 465-472. DOI: 10.1109/trpms.2023.3243576.
Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter S, Carson R, Huang Y, Cai Z. Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16. Frontiers In Neurology 2023, 14: 1045644. PMCID: PMC9945093, DOI: 10.3389/fneur.2023.1045644.
Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter S, Carson R, Huang Y, Cai Z. Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16. Frontiers In Neurology 2023, 14: 1045644. PMID: 36846134, PMCID: PMC9945093, DOI: 10.3389/fneur.2023.1045644.
Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humansSawant‐Basak A, Chen L, Lockwood P, Boyden T, Doran A, Mancuso J, Zasadny K, McCarthy T, Morris E, Carson R, Esterlis I, Huang Y, Nabulsi N, Planeta B, Fullerton T. Investigating CNS distribution of PF‐05212377, a P‐glycoprotein substrate, by translation of 5‐HT6 receptor occupancy from non‐human primates to humans. Biopharmaceutics & Drug Disposition 2023, 44: 48-59. PMID: 36825693, DOI: 10.1002/bdd.2351.
In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human PrimatesSmart K, Zheng M, Holden D, Felchner Z, Zhang L, Han Y, Ropchan J, Carson R, Vasdev N, Huang Y. In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human Primates. Pharmaceuticals 2023, 16: 194. PMCID: PMC9959234, DOI: 10.3390/ph16020194.
In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human PrimatesSmart K, Zheng M, Holden D, Felchner Z, Zhang L, Han Y, Ropchan J, Carson R, Vasdev N, Huang Y. In Vivo Imaging and Kinetic Modeling of Novel Glycogen Synthase Kinase-3 Radiotracers [11C]OCM-44 and [18F]OCM-50 in Non-Human Primates. Pharmaceuticals 2023, 16: 194. PMID: 37259346, PMCID: PMC9959234, DOI: 10.3390/ph16020194.
Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetineRosell D, Slifstein M, Thompson J, Xu X, Perez-Rodriguez M, McClure M, Hazlett E, New A, Nabulsi N, Huang Y, Carson R, Siever L, Abi-Dargham A, Koenigsberg H. Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine. Psychopharmacology 2023, 240: 361-371. PMID: 36640190, DOI: 10.1007/s00213-022-06306-2.
Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDGO'Dell R, Mecca A, Waszak J, Sharp E, Chen M, Naganawa M, Toyonaga T, Lu Y, Chupak A, Cooper E, Lam J, Miller A, Waldner E, Weibley H, Zhao Y, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDG. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.062595.
Assessment of gray matter microstructure and synaptic density in Alzheimer's Disease: a multimodal imaging study with DWI and SV2A PETSalardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer's Disease: a multimodal imaging study with DWI and SV2A PET. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065162.
Assessment of gray matter microstructure and synaptic density in Alzheimer’s Disease: a multimodal imaging study with DWI and SV2A PETSalardini E, Silva‐Rudberg J, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of gray matter microstructure and synaptic density in Alzheimer’s Disease: a multimodal imaging study with DWI and SV2A PET. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.065064.
Visualization of synaptic vesicle protein 2A in a rodent model of familial Alzheimer’s disease with a metabolically stable PET probeZheng C, Chen B, Toyonaga T, Liu M, Nicholson L, Deluca K, Strittmatter S, Carson R, Huang Y, Cai Z. Visualization of synaptic vesicle protein 2A in a rodent model of familial Alzheimer’s disease with a metabolically stable PET probe. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063890.
Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In VivoBini J, Carson R, Cline G. Noninvasive Quantitative PET Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers VMAT2 and Dopamine D2/D3 Receptors In Vivo. 2022, 2592: 61-74. PMID: 36507985, DOI: 10.1007/978-1-0716-2807-2_4.
Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2ANaganawa M, Gallezot J, Finnema S, Maguire R, Mercier J, Nabulsi N, Kervyn S, Henry S, Nicolas J, Huang Y, Chen M, Hannestad J, Klitgaard H, Stockis A, Carson R. Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A. EJNMMI Research 2022, 12: 71. PMID: 36346513, PMCID: PMC9643320, DOI: 10.1186/s13550-022-00944-5.
Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive DisorderHolmes S, Asch R, Davis M, DellaGioia N, Pashankar N, Gallezot J, Nabulsi N, Matuskey D, Sanacora G, Carson R, Blumberg H, Esterlis I. Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder. Biological Psychiatry 2022, 93: 1099-1107. PMID: 36764853, PMCID: PMC10164841, DOI: 10.1016/j.biopsych.2022.10.018.
A 3D atlas of functional human brain energetic connectome based on neuropil distribution.Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.
First-in-human evaluation of 18F-BMS-986327 as a novel PET tracer to assess lysophosphatidic acid receptor 1 (LPA1) target engagement in the lungSmith R, Donnelly D, Gallezot J, Lu Y, Murphy B, Cheng P, Kim J, Charles E, Du S, Holden D, Najafzadeh S, Gao H, Kapinos M, Ropchan J, Nabulsi N, Huang H, Fischer A, Carson R. First-in-human evaluation of 18F-BMS-986327 as a novel PET tracer to assess lysophosphatidic acid receptor 1 (LPA1) target engagement in the lung. 2022, 1164. DOI: 10.1183/13993003.congress-2022.1164.
Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1QSpurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. Science Translational Medicine 2022, 14: eabi8593. PMID: 35648810, PMCID: PMC9554345, DOI: 10.1126/scitranslmed.abi8593.
Imaging of Synaptic Density in Neurodegenerative Disorders.Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. Imaging of Synaptic Density in Neurodegenerative Disorders. Journal Of Nuclear Medicine 2022, 63: 60s-67s. PMID: 35649655, DOI: 10.2967/jnumed.121.263201.
Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET)Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N, Ropchan J, Li S, Ye Y, Felchner Z, Kukis D, Huang Y, Benveniste H, Tarantal AF, Groman S, Carson RE. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3679-3691. PMID: 35633376, PMCID: PMC9826644, DOI: 10.1007/s00259-022-05825-6.
Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PETRossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET. EJNMMI Physics 2022, 9: 32. PMID: 35503134, PMCID: PMC9065222, DOI: 10.1186/s40658-022-00464-0.
PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal ImagingToyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging. Frontiers In Neuroscience 2022, 16: 787404. PMID: 35345546, PMCID: PMC8957200, DOI: 10.3389/fnins.2022.787404.
Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[11C]NR2B-Me, (R)-[18F]of-Me-NB1, and (S)-[18F]of-NB1Smart K, Zheng MQ, Ahmed H, Fang H, Xu Y, Cai L, Holden D, Kapinos M, Haider A, Felchner Z, Ropchan JR, Tamagnan G, Innis RB, Pike VW, Ametamey SM, Huang Y, Carson RE. Comparison of three novel radiotracers for GluN2B-containing NMDA receptors in non-human primates: (R)-[11C]NR2B-Me, (R)-[18F]of-Me-NB1, and (S)-[18F]of-NB1. Cerebrovascular And Brain Metabolism Reviews 2022, 42: 1398-1409. PMID: 35209743, PMCID: PMC9274863, DOI: 10.1177/0271678x221084416.
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐JMecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Wyk B, Arnsten AFT, Huang Y, Carson RE, Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humansAngarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's diseaseMecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease. Neurobiology Of Aging 2021, 111: 44-53. PMID: 34963063, PMCID: PMC8761170, DOI: 10.1016/j.neurobiolaging.2021.11.004.
Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1. Journal Of Clinical Investigation 2021, 131: e150452. PMID: 34651587, PMCID: PMC8516462, DOI: 10.1172/jci150452.
Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699Naganawa M, Nabulsi NB, Matuskey D, Henry S, Ropchan J, Lin SF, Gao H, Pracitto R, Labaree D, Zhang MR, Suhara T, Nishino I, Sabia H, Ozaki S, Huang Y, Carson RE. Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699. Journal Of Nuclear Medicine 2021, 63: 609-614. PMID: 34385336, DOI: 10.2967/jnumed.121.262430.
In vivo evidence of lower synaptic vesicle density in schizophreniaRadhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D’Souza D. In vivo evidence of lower synaptic vesicle density in schizophrenia. Molecular Psychiatry 2021, 26: 7690-7698. PMID: 34135473, DOI: 10.1038/s41380-021-01184-0.
Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's diseaseLu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral TherapyWeiss JJ, Calvi R, Naganawa M, Toyonaga T, Farhadian SF, Chintanaphol M, Chiarella J, Zheng MQ, Ropchan J, Huang Y, Pietrzak RH, Carson RE, Spudich S. Preliminary In Vivo Evidence of Reduced Synaptic Density in Human Immunodeficiency Virus (HIV) Despite Antiretroviral Therapy. Clinical Infectious Diseases 2021, 73: ciab484. PMID: 34050746, PMCID: PMC8528400, DOI: 10.1093/cid/ciab484.
Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysisFang XT, Toyonaga T, Hillmer AT, Matuskey D, Holmes SE, Radhakrishnan R, Mecca AP, van Dyck CH, D’Souza D, Esterlis I, Worhunsky PD, Carson RE. Identifying brain networks in synaptic density PET (11C-UCB-J) with independent component analysis. NeuroImage 2021, 237: 118167. PMID: 34000404, PMCID: PMC8452380, DOI: 10.1016/j.neuroimage.2021.118167.
Imaging the Effect of Ketamine on Synaptic (SV2A) DensityHolmes S, Finnema S, Naganawa M, DellaGioia N, Holden D, Fowles K, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita G, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. Imaging the Effect of Ketamine on Synaptic (SV2A) Density. Biological Psychiatry 2021, 89: s35. DOI: 10.1016/j.biopsych.2021.02.105.
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling studyChen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study. Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain. Cerebral Cortex 2021, 31: 2787-2798. PMID: 33442731, PMCID: PMC8355478, DOI: 10.1093/cercor/bhaa387.
Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2ALi S, Naganawa M, Pracitto R, Najafzadeh S, Holden D, Henry S, Matuskey D, Emery PR, Cai Z, Ropchan J, Nabulsi N, Carson RE, Huang Y. Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 1327-1338. PMID: 33416954, DOI: 10.1007/s00259-020-05149-3.
Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-JO’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
Quantitative Cerebral Blood Flow with PET in the 1980s: Going with the Flow.Carson RE. Quantitative Cerebral Blood Flow with PET in the 1980s: Going with the Flow. Journal Of Nuclear Medicine 2020, 61: 89s-90s. PMID: 33293455, DOI: 10.2967/jnumed.120.252130.
Quantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET ImagingSadasivam P, Fang XT, Toyonaga T, Lee S, Xu Y, Zheng MQ, Spurrier J, Huang Y, Strittmatter SM, Carson RE, Cai Z. Quantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET Imaging. Molecular Imaging And Biology 2020, 23: 372-381. PMID: 33258040, PMCID: PMC8105262, DOI: 10.1007/s11307-020-01567-9.
Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PETNaganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET. EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.
Multimodal investigation of dopamine D2/D3 receptors, default mode network suppression, and cognitive control in cocaine-use disorderWorhunsky PD, Angarita GA, Zhai ZW, Matuskey D, Gallezot JD, Malison RT, Carson RE, Potenza MN. Multimodal investigation of dopamine D2/D3 receptors, default mode network suppression, and cognitive control in cocaine-use disorder. Neuropsychopharmacology 2020, 46: 316-324. PMID: 33007778, PMCID: PMC7852666, DOI: 10.1038/s41386-020-00874-7.
PET Imaging of Synaptic Vesicle Protein 2AFinnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A. 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorderD’Souza D, Radhakrishnan R, Naganawa M, Ganesh S, Nabulsi N, Najafzadeh S, Ropchan J, Ranganathan M, Cortes-Briones J, Huang Y, Carson RE, Skosnik P. Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder. Molecular Psychiatry 2020, 26: 3192-3200. PMID: 32973170, DOI: 10.1038/s41380-020-00891-4.
First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET RadiotracerNaganawa M, Nabulsi N, Henry S, Matuskey D, Lin SF, Slieker L, Schwarz AJ, Kant N, Jesudason C, Ruley K, Navarro A, Gao H, Ropchan J, Labaree D, Carson RE, Huang Y. First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer. Journal Of Nuclear Medicine 2020, 62: 553-560. PMID: 32859711, PMCID: PMC8049371, DOI: 10.2967/jnumed.120.246967.
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation taskSmart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.
Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-JBini J, Holden D, Fontaine K, Mulnix T, Lu Y, Matuskey D, Ropchan J, Nabulsi N, Huang Y, Carson RE. Human adult and adolescent biodistribution and dosimetry of the synaptic vesicle glycoprotein 2A radioligand 11C-UCB-J. EJNMMI Research 2020, 10: 83. PMID: 32666239, PMCID: PMC7359974, DOI: 10.1186/s13550-020-00670-w.
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human CohortNaganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort. Journal Of Nuclear Medicine 2020, 62: 418-421. PMID: 32646875, PMCID: PMC8049341, DOI: 10.2967/jnumed.120.243949.
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PETMecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET. Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studiesBhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.
Inverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjectsBaldassarri SR, Park E, Finnema SJ, Planeta B, Nabulsi N, Najafzadeh S, Ropchan J, Huang Y, Hannestad J, Maloney K, Bhagwagar Z, Carson RE. Inverse changes in raphe and cortical 5‐HT1B receptor availability after acute tryptophan depletion in healthy human subjects. Synapse 2020, 74: e22159. PMID: 32324935, PMCID: PMC7426238, DOI: 10.1002/syn.22159.
Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive bindingSmart K, Gallezot JD, Nabulsi N, Labaree D, Zheng MQ, Huang Y, Carson RE, Hillmer AT, Worhunsky PD. Separating dopamine D2 and D3 receptor sources of [11C]-(+)-PHNO binding potential: Independent component analysis of competitive binding. NeuroImage 2020, 214: 116762. PMID: 32201327, PMCID: PMC7263955, DOI: 10.1016/j.neuroimage.2020.116762.
Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in HumansNaganawa M, Li S, Nabulsi N, Lin SF, Labaree D, Ropchan J, Gao H, Mei M, Henry S, Matuskey D, Carson RE, Huang Y. Kinetic Modeling and Test–Retest Reproducibility of 11C-EKAP and 11C-FEKAP, Novel Agonist Radiotracers for PET Imaging of the κ-Opioid Receptor in Humans. Journal Of Nuclear Medicine 2020, 61: 1636-1642. PMID: 32169917, PMCID: PMC9364890, DOI: 10.2967/jnumed.119.227694.
Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography StudyBini J, Bhatt S, Hillmer AT, Gallezot JD, Nabulsi N, Pracitto R, Labaree D, Kapinos M, Ropchan J, Matuskey D, Sherwin RS, Jastreboff AM, Carson RE, Cosgrove K, Huang Y. Body Mass Index and Age Effects on Brain 11β-Hydroxysteroid Dehydrogenase Type 1: a Positron Emission Tomography Study. Molecular Imaging And Biology 2020, 22: 1124-1131. PMID: 32133575, PMCID: PMC7351613, DOI: 10.1007/s11307-020-01490-z.
Synaptic Changes in Parkinson Disease Assessed with in vivo ImagingMatuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, Henry S, Pittman B, Ropchan J, Nabulsi N, Suridjan I, Comley RA, Huang Y, Finnema SJ, Carson RE. Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging. Annals Of Neurology 2020, 87: 329-338. PMID: 31953875, PMCID: PMC7065227, DOI: 10.1002/ana.25682.
Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with VicraLu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE. Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra. Journal Of Nuclear Medicine 2020, 61: 1397-1403. PMID: 32005770, PMCID: PMC7456171, DOI: 10.2967/jnumed.119.235515.
Synthesis and Preclinical Evaluation of an 18F‑Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT‑2Cai Z, Li S, Zhang W, Pracitto R, Wu X, Baum E, Finnema SJ, Holden D, Toyonaga T, Lin SF, Lindemann M, Shirali A, Labaree DC, Ropchan J, Nabulsi N, Carson RE, Huang Y. Synthesis and Preclinical Evaluation of an 18F‑Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT‑2. ACS Chemical Neuroscience 2020, 11: 592-603. PMID: 31961649, DOI: 10.1021/acschemneuro.9b00618.
PET imaging of mGluR5 in Alzheimer’s diseaseMecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease. Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
[11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation NecrosisTran TT, Gallezot JD, Jilaveanu LB, Zito C, Turcu G, Lim K, Nabulsi N, Huang H, Huttner A, Kluger HM, Chiang VL, Carson R. [11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis. Molecular Imaging 2020, 19: 1536012120968669. PMID: 33147119, PMCID: PMC7649862, DOI: 10.1177/1536012120968669.
Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PETHolmes SE, Gallezot JD, Davis MT, DellaGioia N, Matuskey D, Nabulsi N, Krystal JH, Javitch JA, DeLorenzo C, Carson RE, Esterlis I. Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 2254-2264. PMID: 31744389, PMCID: PMC7585925, DOI: 10.1177/0271678x19886316.
Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRBSanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRB. International Journal Of Obesity 2019, 44: 964-967. PMID: 31636373, PMCID: PMC7259982, DOI: 10.1038/s41366-019-0471-4.
PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 DiabetesBini J, Sanchez-Rangel E, Gallezot JD, Naganawa M, Nabulsi N, Lim K, Najafzadeh S, Shirali A, Ropchan J, Matuskey D, Huang Y, Herold K, Harris PE, Sherwin RS, Carson RE, Cline GW. PET Imaging of Pancreatic Dopamine D2 and D3 Receptor Density with 11C-(+)-PHNO in Type 1 Diabetes. Journal Of Nuclear Medicine 2019, 61: 570-576. PMID: 31601695, PMCID: PMC7198375, DOI: 10.2967/jnumed.119.234013.
Assessment of a white matter reference region for 11C-UCB-J PET quantificationRossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE. Assessment of a white matter reference region for 11C-UCB-J PET quantification. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 1890-1901. PMID: 31570041, PMCID: PMC7446568, DOI: 10.1177/0271678x19879230.
Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distributionRen S, Lu Y, Bertolli O, Thielemans K, Carson RE. Event-by-event non-rigid data-driven PET respiratory motion correction methods: comparison of principal component analysis and centroid of distribution. Physics In Medicine And Biology 2019, 64: 165014. PMID: 30822762, DOI: 10.1088/1361-6560/ab0bc9.
Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET studyTuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot J, Hillmer A, Huang Y, Höglund C, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego C, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study. European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2329-2338. PMID: 31363804, PMCID: PMC6717599, DOI: 10.1007/s00259-019-04403-7.
In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild birdLattin CR, Merullo DP, Riters LV, Carson RE. In vivo imaging of D2 receptors and corticosteroids predict behavioural responses to captivity stress in a wild bird. Scientific Reports 2019, 9: 10407. PMID: 31320692, PMCID: PMC6639298, DOI: 10.1038/s41598-019-46845-x.
Human Positron Emission Tomography NeuroimagingHooker JM, Carson RE. Human Positron Emission Tomography Neuroimaging. Annual Review Of Biomedical Engineering 2019, 21: 551-581. PMID: 31167104, DOI: 10.1146/annurev-bioeng-062117-121056.
In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer DiseaseToyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease. Journal Of Nuclear Medicine 2019, 60: 1780-1786. PMID: 31101744, PMCID: PMC6894376, DOI: 10.2967/jnumed.118.223867.
Quantification of PET infusion studies without true equilibrium: A tissue clearance correctionHillmer AT, Carson RE. Quantification of PET infusion studies without true equilibrium: A tissue clearance correction. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 860-874. PMID: 31088233, PMCID: PMC7168787, DOI: 10.1177/0271678x19850000.
Brain-Dedicated Emission Tomography Systems: A Perspective on Requirements for Clinical Research and Clinical Needs in Brain ImagingCarson R, Kuo P. Brain-Dedicated Emission Tomography Systems: A Perspective on Requirements for Clinical Research and Clinical Needs in Brain Imaging. IEEE Transactions On Radiation And Plasma Medical Sciences 2019, 3: 254-261. DOI: 10.1109/trpms.2019.2912129.
Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography studyMartinez D, Slifstein M, Matuskey D, Nabulsi N, Zheng MQ, Lin SF, Ropchan J, Urban N, Grassetti A, Chang D, Salling M, Foltin R, Carson RE, Huang Y. Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study. Neuropsychopharmacology 2019, 44: 1720-1727. PMID: 31026862, PMCID: PMC6785004, DOI: 10.1038/s41386-019-0398-4.
Parametric Imaging With PET and SPECTGallezot J, Lu Y, Naganawa M, Carson R. Parametric Imaging With PET and SPECT. IEEE Transactions On Radiation And Plasma Medical Sciences 2019, 4: 1-23. DOI: 10.1109/trpms.2019.2908633.
A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteersFinnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas J, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE. A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers. Epilepsia 2019, 60: 958-967. PMID: 30924924, PMCID: PMC6532410, DOI: 10.1111/epi.14701.
First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. First in-human PET study and kinetic evaluation of [18F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 695-704. PMID: 30895878, PMCID: PMC7168798, DOI: 10.1177/0271678x19838633.
Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human BrainGallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.
Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PETLu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.
Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman PrimatesNabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker L, Jesudason C, Barth V, Navarro A, Kant N, Carson RE, Huang Y. Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates. Journal Of Nuclear Medicine 2019, 60: 1147-1153. PMID: 30733324, DOI: 10.2967/jnumed.118.222034.
Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman PrimatesLi S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, Gao H, Labaree D, Nabulsi N, Carson RE, Huang Y. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chemical Neuroscience 2018, 10: 1544-1554. PMID: 30396272, PMCID: PMC6810685, DOI: 10.1021/acschemneuro.8b00526.
High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer TumorsKelada OJ, Decker RH, Nath SK, Johung KL, Zheng MQ, Huang Y, Gallezot JD, Liu C, Carson RE, Oelfke U, Carlson DJ. High Single Doses of Radiation May Induce Elevated Levels of Hypoxia in Early-Stage Non-Small Cell Lung Cancer Tumors. International Journal Of Radiation Oncology • Biology • Physics 2018, 102: 174-183. PMID: 30102194, PMCID: PMC6092043, DOI: 10.1016/j.ijrobp.2018.05.032.
Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imagingCline GW, Naganawa M, Chen L, Chidsey K, Carvajal-Gonzalez S, Pawlak S, Rossulek M, Zhang Y, Bini J, McCarthy TJ, Carson RE, Calle RA. Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging. Diabetologia 2018, 61: 2598-2607. PMID: 29721633, DOI: 10.1007/s00125-018-4624-0.
Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 DiabetesNaganawa M, Lim K, Nabulsi NB, Lin SF, Labaree D, Ropchan J, Herold KC, Huang Y, Harris P, Ichise M, Cline GW, Carson RE. Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes. Molecular Imaging And Biology 2018, 20: 835-845. PMID: 29468404, PMCID: PMC6533199, DOI: 10.1007/s11307-018-1170-6.
Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET DataLu Y, Fontaine K, Mulnix T, Onofrey JA, Ren S, Panin V, Jones J, Casey ME, Barnett R, Kench P, Fulton R, Carson RE, Liu C. Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data. Journal Of Nuclear Medicine 2018, 59: 1480-1486. PMID: 29439015, PMCID: PMC6126443, DOI: 10.2967/jnumed.117.203000.
Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia SubjectsD’Souza D, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH, Ahn K, Bielen K, Carbuto M, Deaso E, D’Souza D, Ranganathan M, Naganawa M, Ranganathan M, D’Souza D, Nabulsi N, Zheng M, Lin S, Huang Y, Carson R, Driesen N, Ahn K, Morgan P, Suckow R, He G, McCarthy G, Krystal J, Johannesen J, Kenney J, Gelernter J, Gueorguieva R, Pittman B. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry 2018, 84: 413-421. PMID: 29499855, PMCID: PMC6068006, DOI: 10.1016/j.biopsych.2017.12.019.
Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNOBini J, Naganawa M, Nabulsi N, Huang Y, Ropchan J, Lim K, Najafzadeh S, Herold KC, Cline GW, Carson RE. Evaluation of PET Brain Radioligands for Imaging Pancreatic β-Cell Mass: Potential Utility of 11C-(+)-PHNO. Journal Of Nuclear Medicine 2018, 59: 1249-1254. PMID: 29371405, PMCID: PMC6071501, DOI: 10.2967/jnumed.117.197285.
Cardiac‐gated parametric images from 82Rb PET from dynamic frames and direct 4D reconstructionGermino M, Carson RE. Cardiac‐gated parametric images from 82Rb PET from dynamic frames and direct 4D reconstruction. Medical Physics 2017, 45: 639-654. PMID: 29205378, PMCID: PMC5807225, DOI: 10.1002/mp.12710.
Quantitative PET Imaging in Drug Development: Estimation of Target OccupancyNaganawa M, Gallezot JD, Rossano S, Carson RE. Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy. Bulletin Of Mathematical Biology 2017, 81: 3508-3541. PMID: 29230702, DOI: 10.1007/s11538-017-0374-2.
Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus MonkeysGallezot JD, Nabulsi NB, Holden D, Lin SF, Labaree D, Ropchan J, Najafzadeh S, Donnelly DJ, Cao K, Bonacorsi S, Seiders J, Roppe J, Hayes W, Huang Y, Du S, Carson RE. Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys. Journal Of Nuclear Medicine 2017, 59: 327-333. PMID: 28864634, DOI: 10.2967/jnumed.117.195073.
Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography studyLattin CR, Stabile FA, Carson RE. Estradiol modulates neural response to conspecific and heterospecific song in female house sparrows: An in vivo positron emission tomography study. PLOS ONE 2017, 12: e0182875. PMID: 28832614, PMCID: PMC5568339, DOI: 10.1371/journal.pone.0182875.
Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humansFinnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. Cerebrovascular And Brain Metabolism Reviews 2017, 38: 2041-2052. PMID: 28792356, PMCID: PMC6259313, DOI: 10.1177/0271678x17724947.
Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primatesHillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP. Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates. EJNMMI Research 2017, 7: 59. PMID: 28741281, PMCID: PMC5524658, DOI: 10.1186/s13550-017-0305-0.
Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidenceHolmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I, Friedman M, Kowall N, Brady C, McKee A, Stein T, Huber B, Kaloupek D, Alvarez V, Benedek D, Ursano R, Williamson D, Cruz D, Young K, Duman R, Krystal J, Mash D, Hardegree M, Serlin G. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 8390-8395. PMID: 28716937, PMCID: PMC5547601, DOI: 10.1073/pnas.1701749114.
Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levelsGermino M, Gallezot JD, Yan J, Carson RE. Direct reconstruction of parametric images for brain PET with event-by-event motion correction: evaluation in two tracers across count levels. Physics In Medicine And Biology 2017, 62: 5344-5364. PMID: 28504644, PMCID: PMC5783541, DOI: 10.1088/1361-6560/aa731f.
Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distributionRen S, Jin X, Chan C, Jian Y, Mulnix T, Liu C, Carson RE. Data-driven event-by-event respiratory motion correction using TOF PET list-mode centroid of distribution. Physics In Medicine And Biology 2017, 62: 4741-4755. PMID: 28520558, PMCID: PMC6048592, DOI: 10.1088/1361-6560/aa700c.
Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen MeasurementsKelada OJ, Rockwell S, Zheng MQ, Huang Y, Liu Y, Booth CJ, Decker RH, Oelfke U, Carson RE, Carlson DJ. Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen Measurements. Molecular Imaging And Biology 2017, 19: 893-902. PMID: 28409339, PMCID: PMC5640490, DOI: 10.1007/s11307-017-1083-9.
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depressionEsterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression. Molecular Psychiatry 2017, 23: 824-832. PMID: 28397841, PMCID: PMC5636649, DOI: 10.1038/mp.2017.58.
Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging StudyAbdallah CG, Hannestad J, Mason GF, Holmes SE, DellaGioia N, Sanacora G, Jiang L, Matuskey D, Satodiya R, Gasparini F, Lin X, Javitch J, Planeta B, Nabulsi N, Carson RE, Esterlis I. Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 449-456. PMID: 28993818, PMCID: PMC5630181, DOI: 10.1016/j.bpsc.2017.03.019.
In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependenceHillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence. Molecular Psychiatry 2017, 22: 1759-1766. PMID: 28242869, PMCID: PMC5573660, DOI: 10.1038/mp.2017.10.
Regional and network-based alterations in D2/D3 receptor availability in cocaine use disorderWorhunsky P, Matuskey D, Gallezot J, Nabulsi N, Angarita G, Calhoun V, Malison R, Potenza M, Carson R. Regional and network-based alterations in D2/D3 receptor availability in cocaine use disorder. Drug And Alcohol Dependence 2017, 171: e219. DOI: 10.1016/j.drugalcdep.2016.08.598.
PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humansHillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y. PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1042-1050. PMID: 28120003, PMCID: PMC5400702, DOI: 10.1007/s00259-017-3621-8.
Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorderWorhunsky PD, Matuskey D, Gallezot JD, Gaiser EC, Nabulsi N, Angarita GA, Calhoun VD, Malison RT, Potenza MN, Carson RE. Regional and source-based patterns of [11C]-(+)-PHNO binding potential reveal concurrent alterations in dopamine D2 and D3 receptor availability in cocaine-use disorder. NeuroImage 2017, 148: 343-351. PMID: 28110088, PMCID: PMC5344702, DOI: 10.1016/j.neuroimage.2017.01.045.
Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboonsNaganawa M, Lin SF, Lim K, Labaree D, Ropchan J, Harris P, Huang Y, Ichise M, Carson RE, Cline GW. Evaluation of pancreatic VMAT2 binding with active and inactive enantiomers of 18F-FP-DTBZ in baboons. Nuclear Medicine And Biology 2016, 43: 743-751. PMID: 27673755, PMCID: PMC5248981, DOI: 10.1016/j.nucmedbio.2016.08.018.
Quantification of myocardial blood flow with 82Rb: Validation with 15O-water using time-of-flight and point-spread-function modelingGermino M, Ropchan J, Mulnix T, Fontaine K, Nabulsi N, Ackah E, Feringa H, Sinusas AJ, Liu C, Carson RE. Quantification of myocardial blood flow with 82Rb: Validation with 15O-water using time-of-flight and point-spread-function modeling. EJNMMI Research 2016, 6: 68. PMID: 27650280, PMCID: PMC5030203, DOI: 10.1186/s13550-016-0215-6.
Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746Gallezot JD, Planeta B, Nabulsi N, Palumbo D, Li X, Liu J, Rowinski C, Chidsey K, Labaree D, Ropchan J, Lin SF, Sawant-Basak A, McCarthy TJ, Schmidt AW, Huang Y, Carson RE. Determination of receptor occupancy in the presence of mass dose: [11C]GSK189254 PET imaging of histamine H3 receptor occupancy by PF-03654746. Cerebrovascular And Brain Metabolism Reviews 2016, 37: 1095-1107. PMID: 27207170, PMCID: PMC5363483, DOI: 10.1177/0271678x16650697.
Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brainHillmer AT, Esterlis I, Gallezot JD, Bois F, Zheng MQ, Nabulsi N, Lin SF, Papke RL, Huang Y, Sabri O, Carson RE, Cosgrove KP. Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (−)-[18F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain. NeuroImage 2016, 141: 71-80. PMID: 27426839, PMCID: PMC5026941, DOI: 10.1016/j.neuroimage.2016.07.026.
First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430Naganawa M, Waterhouse RN, Nabulsi N, Lin SF, Labaree D, Ropchan J, Tarabar S, DeMartinis N, Ogden A, Banerjee A, Huang Y, Carson RE. First-in-Human Assessment of the Novel PDE2A PET Radiotracer 18F-PF-05270430. Journal Of Nuclear Medicine 2016, 57: 1388-1395. PMID: 27103022, PMCID: PMC5093918, DOI: 10.2967/jnumed.115.166850.
Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and ImagingHan L, Kong DK, Zheng MQ, Murikinati S, Ma C, Yuan P, Li L, Tian D, Cai Q, Ye C, Holden D, Park JH, Gao X, Thomas JL, Grutzendler J, Carson RE, Huang Y, Piepmeier JM, Zhou J. Increased Nanoparticle Delivery to Brain Tumors by Autocatalytic Priming for Improved Treatment and Imaging. ACS Nano 2016, 10: 4209-4218. PMID: 26967254, PMCID: PMC5257033, DOI: 10.1021/acsnano.5b07573.
OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor bindingPittenger C, Adams TG, Gallezot JD, Crowley MJ, Nabulsi N, Ropchan J, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. Journal Of Affective Disorders 2016, 196: 87-96. PMID: 26919057, PMCID: PMC4808438, DOI: 10.1016/j.jad.2016.02.021.
Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the BrainNabulsi N, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten MC, Lin SF, Deo A, Price N, Wood M, Lara-Jaime T, Montel F, Laruelle M, Carson RE, Hannestad J, Huang Y. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. Journal Of Nuclear Medicine 2016, 57: 777-784. PMID: 26848175, DOI: 10.2967/jnumed.115.168179.
In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEBDeLorenzo C, Gallezot JD, Gardus J, Yang J, Planeta B, Nabulsi N, Ogden RT, Labaree DC, Huang YH, Mann JJ, Gasparini F, Lin X, Javitch JA, Parsey RV, Carson RE, Esterlis I. In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB. Cerebrovascular And Brain Metabolism Reviews 2016, 37: 2716-2727. PMID: 27742888, PMCID: PMC5536783, DOI: 10.1177/0271678x16673646.
Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of actionNicolas JM, Hannestad J, Holden D, Kervyn S, Nabulsi N, Tytgat D, Huang Y, Chanteux H, Staelens L, Matagne A, Mathy FX, Mercier J, Stockis A, Carson RE, Klitgaard H. Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A (SV2A) ligand with preclinical evidence of high brain permeability and fast onset of action. Epilepsia 2015, 57: 201-209. PMID: 26663401, DOI: 10.1111/epi.13267.
Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050Naganawa M, Dickinson GL, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE. Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050. Journal Of Pharmacology And Experimental Therapeutics 2015, 356: 260-266. PMID: 26628406, PMCID: PMC4727157, DOI: 10.1124/jpet.115.229278.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PETSandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O’Connor K, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 12468-12473. PMID: 26385967, PMCID: PMC4603509, DOI: 10.1073/pnas.1511003112.
Reduced Brain Cannabinoid Receptor Availability in SchizophreniaRanganathan M, Cortes-Briones J, Radhakrishnan R, Thurnauer H, Planeta B, Skosnik P, Gao H, Labaree D, Neumeister A, Pittman B, Surti T, Huang Y, Carson RE, D’Souza D. Reduced Brain Cannabinoid Receptor Availability in Schizophrenia. Biological Psychiatry 2015, 79: 997-1005. PMID: 26432420, PMCID: PMC4884543, DOI: 10.1016/j.biopsych.2015.08.021.
Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion ParadigmXia Y, Zheng MQ, Holden D, Lin SF, Kapinos M, Ropchan J, Gallezot JD, Huang Y, Carson RE. Measurement of Bmax and Kd with the Glycine Transporter 1 Radiotracer 18F-MK6577 using a Novel Multi-Infusion Paradigm. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 2001-2009. PMID: 26198176, PMCID: PMC4671121, DOI: 10.1038/jcbfm.2015.163.
Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humansPark E, Sullivan JM, Planeta B, Gallezot JD, Lim K, Lin SF, Ropchan J, McCarthy TJ, Ding YS, Morris ED, Williams WA, Huang Y, Carson RE. Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42: 1530-1541. PMID: 26044120, PMCID: PMC5467218, DOI: 10.1007/s00259-015-3094-6.
11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areasPark E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O’Connor K, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. 11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42: 1081-1092. PMID: 25833352, DOI: 10.1007/s00259-015-3043-4.
Imaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligandHwang JJ, Yeckel CW, Gallezot JD, Aguiar RB, Ersahin D, Gao H, Kapinos M, Nabulsi N, Huang Y, Cheng D, Carson RE, Sherwin R, Ding YS. Imaging human brown adipose tissue under room temperature conditions with 11C-MRB, a selective norepinephrine transporter PET ligand. Metabolism 2015, 64: 747-755. PMID: 25798999, PMCID: PMC4408242, DOI: 10.1016/j.metabol.2015.03.001.
Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake InhibitorSmith J, Patil D, Daniels O, Ding YS, Gallezot JD, Henry S, Kim K, Kshirsagar S, Martin W, Obedencio G, Stangeland E, Tsuruda P, Williams W, Carson R, Patil S. Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor. The International Journal Of Neuropsychopharmacology 2015, 18: pyu027. PMID: 25522383, PMCID: PMC4368888, DOI: 10.1093/ijnp/pyu027.
Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid ReceptorNaganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y. Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor. Journal Of Nuclear Medicine 2015, 56: 243-248. PMID: 25593119, PMCID: PMC4322754, DOI: 10.2967/jnumed.114.147975.
Applications of the line-of-response probability density function resolution model in PET list mode reconstructionJian Y, Yao R, Mulnix T, Jin X, Carson RE. Applications of the line-of-response probability density function resolution model in PET list mode reconstruction. Physics In Medicine And Biology 2014, 60: 253-278. PMID: 25490063, PMCID: PMC4820078, DOI: 10.1088/0031-9155/60/1/253.
Evaluation of bias and variance in low-count OSEM list mode reconstructionJian Y, Planeta B, Carson RE. Evaluation of bias and variance in low-count OSEM list mode reconstruction. Physics In Medicine And Biology 2014, 60: 15-29. PMID: 25479254, PMCID: PMC4823773, DOI: 10.1088/0031-9155/60/1/15.
Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeysGallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.
In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In Vivo Ketamine-Induced Changes in [11C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5. Biological Psychiatry 2014, 77: 266-275. PMID: 25156701, PMCID: PMC4277907, DOI: 10.1016/j.biopsych.2014.06.024.
Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial InnervationSinusas AJ, Lazewatsky J, Brunetti J, Heller G, Srivastava A, Liu YH, Sparks R, Puretskiy A, Lin SF, Crane P, Carson RE, Lee LV. Biodistribution and Radiation Dosimetry of LMI1195: First-in-Human Study of a Novel 18F-Labeled Tracer for Imaging Myocardial Innervation. Journal Of Nuclear Medicine 2014, 55: 1445-1451. PMID: 24994931, DOI: 10.2967/jnumed.114.140137.
WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body RadiotherapyKelada O, Decker R, Zheng M, Huang Y, Xia Y, Gallezot J, Liu C, Rockwell S, Carson R, Oelfke U, Carlson D. WE‐G‐BRD‐06: Variation in Dynamic Positron Emission Tomography Imaging of Tumor Hypoxia in Early Stage Non‐Small Cell Lung Cancer Patients Undergoing Stereotactic Body Radiotherapy. Medical Physics 2014, 41: 520-520. DOI: 10.1118/1.4889490.
5:30 PM IN VIVO EVIDENCE OF REDUCED BRAIN CANNABINOID RECEPTORS IN SCHIZOPHRENIAD'Souza D, Thurnauer H, Ranganathan M, Cortes J, Radhakrishnan R, Carson R, Huang Y, Planeta-Wilson B. 5:30 PM IN VIVO EVIDENCE OF REDUCED BRAIN CANNABINOID RECEPTORS IN SCHIZOPHRENIA. Schizophrenia Research 2014, 153: s52. DOI: 10.1016/s0920-9964(14)70171-9.
Poster #S268 DECREASED BRAIN CANNABINOID RECEPTOR (CB1R) AVAILABILITY IN CANNABIS DEPENDENCE RAPIDLY NORMALIZES WITH ABSTINENCED'Souza D, Cortes J, Ranganathan M, Thurnauer H, Planeta B, Radhakrishnan R, Huang Y, Carson R, Skosnik P. Poster #S268 DECREASED BRAIN CANNABINOID RECEPTOR (CB1R) AVAILABILITY IN CANNABIS DEPENDENCE RAPIDLY NORMALIZES WITH ABSTINENCE. Schizophrenia Research 2014, 153: s187. DOI: 10.1016/s0920-9964(14)70547-x.
Imaging Neurochemical Transmission in Substance Abuse Commonalities and Differences Across AddictionsMartinez D, Grassetti A, Huang Y, Slifstein M, Kegeles L, Carson R, Carpenter K, Nunes E, Foltin R. Imaging Neurochemical Transmission in Substance Abuse Commonalities and Differences Across Addictions. 2014, 176. DOI: 10.1016/b978-0-12-800044-1.00155-0.
Feasible Uniform-Resolution Penalized Likelihood Reconstruction for Static- and Multi-frame 3D PETJian Y, Carson R. Feasible Uniform-Resolution Penalized Likelihood Reconstruction for Static- and Multi-frame 3D PET. 2013, 1-5. DOI: 10.1109/nssmic.2013.6829035.
Effect of Subsets on Bias and Variance in Low-count Iterative PET ReconstructionJian Y, Carson R. Effect of Subsets on Bias and Variance in Low-count Iterative PET Reconstruction. 2013, 1-4. DOI: 10.1109/nssmic.2013.6829220.
Evaluation of motion correction methods in human brain PET imaging—A simulation study based on human motion dataJin X, Mulnix T, Gallezot J, Carson RE. Evaluation of motion correction methods in human brain PET imaging—A simulation study based on human motion data. Medical Physics 2013, 40: 102503. PMID: 24089924, PMCID: PMC3785538, DOI: 10.1118/1.4819820.
List-mode reconstruction for the FOCUS-220 with motion correction and spatially-variant probability density functions: Application to awake monkey imagingJin X, Jian Y, Mulnix T, Sandiego C, Yao R, Carson R. List-mode reconstruction for the FOCUS-220 with motion correction and spatially-variant probability density functions: Application to awake monkey imaging. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 2985-2990. DOI: 10.1109/nssmic.2012.6551682.
Dynamic assessment of head motion compensation for the HRRTJin X, Mulnix T, Gallezot J, Carson R. Dynamic assessment of head motion compensation for the HRRT. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 2867-2872. DOI: 10.1109/nssmic.2012.6551654.
Uniform Spatial resolution list mode reconstruction for the HRRTJian Y, Carson R. Uniform Spatial resolution list mode reconstruction for the HRRT. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 2445-2448. DOI: 10.1109/nssmic.2012.6551556.
Myocardial blood flow from dynamic PET using Independent Component AnalysisKarpikov A, Tagare H, Mulnix T, Gallezot J, Sinusas A, Liu C, Carson R. Myocardial blood flow from dynamic PET using Independent Component Analysis. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 2222-2226. DOI: 10.1109/nssmic.2012.6551506.
List-mode reconstruction for the Biograph mCT with probabilistic line-of-response positioning and event-by-event motion correctionJin X, Chan C, Mulnix T, Liu C, Carson R. List-mode reconstruction for the Biograph mCT with probabilistic line-of-response positioning and event-by-event motion correction. 2011 IEEE Nuclear Science Symposium Conference Record 2013, 3682-3687. DOI: 10.1109/nssmic.2012.6551847.
MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic ModelingKelada O, Rockwell S, Carson R, Decker R, Oelfke U, Carlson D. MO‐D‐141‐01: Quantification of Tumor Hypoxia Using [18F]‐Fluoromisonidazole Positron Emission Tomography and Tracer Kinetic Modeling. Medical Physics 2013, 40: 399-399. DOI: 10.1118/1.4815248.
Direct 4-D PET List Mode Parametric Reconstruction with a Novel EM AlgorithmYan J, Planeta-Wilson B, Carson RE. Direct 4-D PET List Mode Parametric Reconstruction with a Novel EM Algorithm. IEEE Transactions On Medical Imaging 2012, 31: 2213-2223. PMID: 22929383, PMCID: PMC3660152, DOI: 10.1109/tmi.2012.2212451.
IC‐O1‐03: Amyloid burden and neuropsychological performance in presymptomatic first‐degree relatives at varying APOE‐ɛ4 risk for Alzheimer's diseaseDyck C, van Dyck C, Barcelos N, Brück A, Planeta‐Wilson B, Planeta-Wilson B, Gelernter J, Carson R. IC‐O1‐03: Amyloid burden and neuropsychological performance in presymptomatic first‐degree relatives at varying APOE‐ɛ4 risk for Alzheimer's disease. Alzheimer's & Dementia 2012, 8: p5-p5. DOI: 10.1016/j.jalz.2012.05.018.
In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PETNormandin MD, Petersen KF, Ding YS, Lin SF, Naik S, Fowles K, Skovronsky DM, Herold KC, McCarthy TJ, Calle RA, Carson RE, Treadway JL, Cline GW. In Vivo Imaging of Endogenous Pancreatic β-Cell Mass in Healthy and Type 1 Diabetic Subjects Using 18F-Fluoropropyl-Dihydrotetrabenazine and PET. Journal Of Nuclear Medicine 2012, 53: 908-916. PMID: 22573821, PMCID: PMC3737743, DOI: 10.2967/jnumed.111.100545.
Validation of the Spatially Variant Probability Density Functions for the HRRTJian Y, Yao R, Mulnix T, Carson R. Validation of the Spatially Variant Probability Density Functions for the HRRT. 2011, 2443-2446. DOI: 10.1109/nssmic.2011.6152664.
P4‐253: Receptor occupancy of the 5‐HT6 receptor antagonist SAM‐760 in non‐human primates and healthy human volunteersComery T, Zasadny K, Morris E, Antinew J, Bell J, Billing B, Boyden T, Esterlis I, Huang Y, Kupiec J, Kuszpit K, Leil T, Nabulsi N, Planeta‐Wilson B, Planeta-Wilson B, Plotka A, Skaddan M, Vandal G, Carson R, Katz E, McCarthy T. P4‐253: Receptor occupancy of the 5‐HT6 receptor antagonist SAM‐760 in non‐human primates and healthy human volunteers. Alzheimer's & Dementia 2011, 7: s794-s795. DOI: 10.1016/j.jalz.2011.05.2278.
IC‐P‐106: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's diseasevan Dyck C, Dyck C, Brück A, Barcelos N, Planeta-Wilson B, Planeta‐Wilson B, Benincasa A, MacAvoy M, Ding Y, Ding Y, Gelernter J, Carson R. IC‐P‐106: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease. Alzheimer's & Dementia 2011, 7: s51-s52. DOI: 10.1016/j.jalz.2011.05.071.
P3‐431: Translational receptor occupancy for the 5‐HT4 partial agonist PF‐04995274 in rats, non‐human primates and healthy volunteersGrimwood S, Drummond E, Zasadny K, Skaddan M, Brodney M, Coffman K, Nicholas T, Duvvuri S, Raunig D, Leurent C, Rowinski C, Park Y, Park Y, Ogden A, Sawant A, Miller E, Rapp T, Wang Y, Planeta-Wilson B, Planeta‐Wilson B, Ropchan J, Carson R, Morris E, Ding Y, Ding Y, Katz E. P3‐431: Translational receptor occupancy for the 5‐HT4 partial agonist PF‐04995274 in rats, non‐human primates and healthy volunteers. Alzheimer's & Dementia 2011, 7: s653-s653. DOI: 10.1016/j.jalz.2011.05.1875.
P1‐387: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's diseasevan Dyck C, Dyck C, Brück A, Barcelos N, Planeta-Wilson B, Planeta‐Wilson B, Benincasa A, MacAvoy M, Ding Y, Ding Y, Gelernter J, Carson R. P1‐387: Amyloid‐ß burden and neuropsychological test performance in cognitively normal first‐degree relatives at varying genetic risk for Alzheimer's disease. Alzheimer's & Dementia 2011, 7: s236-s236. DOI: 10.1016/j.jalz.2011.05.668.
Segmentation of Rat Spinal Cord in PET Using Spatiotemporal InformationFung E, Weinzimmer D, Strittmatter S, Huang Y, Carson R. Segmentation of Rat Spinal Cord in PET Using Spatiotemporal Information. 2010, 3605-3609. DOI: 10.1109/nssmic.2010.5874483.
Multiple Acquisition Frame-Based Motion Correction for Awake Monkey PET ImagingJin X, Sandiego C, Mulnix T, Carson R. Multiple Acquisition Frame-Based Motion Correction for Awake Monkey PET Imaging. 2010, 2915-2920. DOI: 10.1109/nssmic.2010.5874329.
Count-rate dependent resolution degradation from pulse pile-up on the HRRTJian Y, Mulnix T, Carson R. Count-rate dependent resolution degradation from pulse pile-up on the HRRT. 2010, 2765-2768. DOI: 10.1109/nssmic.2010.5874297.
Evaluation of Direct 4D Parametric Reconstruction with Low Count Human PET DataYan J, Planeta-Wilson B, Gallezot J, Carson R. Evaluation of Direct 4D Parametric Reconstruction with Low Count Human PET Data. 2010, 2259-2262. DOI: 10.1109/nssmic.2010.5874185.
Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PETCosgrove K, Gallezot J, Weinzimmer D, Fowles K, Labaree D, Zheng M, Lim K, Carson R, Morris E. Imaging drug-induced dopamine release in rhesus monkeys with [11C]PHNO versus [11C]raclopride PET. NeuroImage 2010, 52: s79. DOI: 10.1016/j.neuroimage.2010.04.063.
Attenuation correction for awake non-human primate PET using transmission data from anesthetized studiesSandiego C, Mulnix T, Carson R. Attenuation correction for awake non-human primate PET using transmission data from anesthetized studies. NeuroImage 2010, 52: s182. DOI: 10.1016/j.neuroimage.2010.04.148.
Synthesis and evaluation of [C-11]LY2795050, an antagonist PET imaging tracer for the kappa opioid receptorsZheng M, Nabulsi N, Tomasi G, Mitch C, Quimby S, Barth V, Rash K, Masters J, Navarro A, Seest E, Carson R, Huang Y. Synthesis and evaluation of [C-11]LY2795050, an antagonist PET imaging tracer for the kappa opioid receptors. NeuroImage 2010, 52: s120. DOI: 10.1016/j.neuroimage.2010.04.098.
Pharmacokinetic characterization of compounds with increased target residence times using PETSalinas C, Weinzimmer D, Searle G, Labaree D, Ding Y, Huang Y, Rabiner E, Carson R, Gunn R. Pharmacokinetic characterization of compounds with increased target residence times using PET. NeuroImage 2010, 52: s210-s211. DOI: 10.1016/j.neuroimage.2010.04.172.
The role of norepinephrine transporter in attention deficit hyperactivity disorderDing Y, Planeta-Wilson B, Hannestad J, Gallezot J, Lin S, Williams W, Quinlan D, Carson R, van Dyck C. The role of norepinephrine transporter in attention deficit hyperactivity disorder. NeuroImage 2010, 52: s108. DOI: 10.1016/j.neuroimage.2010.04.087.
Imaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility studyHuang Y, Williams W, Tomasi G, Zheng M, Lin S, Ropchan J, Labaree D, Olsen J, Tabriz M, Planeta-Wilson B, Tauscher J, Ding Y, Carson R, Neumeister A. Imaging the kappa opioid receptor in humans with [11C]LY2795050: Tracer evaluation and test–retest reproducibility study. NeuroImage 2010, 52: s199. DOI: 10.1016/j.neuroimage.2010.04.161.
PET measurement of nicotine evoked dopamine releaseRidler K, Gallezot J, Carson R, Weinzimmer D, Slifstein M, Gunn R, Laruelle M, Rabiner E. PET measurement of nicotine evoked dopamine release. NeuroImage 2010, 52: s177. DOI: 10.1016/j.neuroimage.2010.04.144.
Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scannerGallezot J, Weinzimmer D, Fowles K, Labaree D, Cosgrove K, Ding Y, Morris E, Carson R. Kinetic modeling of [11C]PHNO in rhesus monkeys using the Focus 220 PET scanner. NeuroImage 2010, 52: s173. DOI: 10.1016/j.neuroimage.2010.04.141.
Modeling analysis of the new kappa opioid receptor antagonist tracer [11C]LY2795050 in humansTomasi G, Lin S, Zheng M, Planeta-Wilson B, Henry S, Goebl N, Tauscher J, Huang H, Neumeister A, Carson R. Modeling analysis of the new kappa opioid receptor antagonist tracer [11C]LY2795050 in humans. NeuroImage 2010, 52: s39. DOI: 10.1016/j.neuroimage.2010.04.221.
A correction algorithm for carryover of tracer in paired C-11 studies: Application to the H-3 receptor antagonist [C-11]GSK189254Planeta-Wilson B, Labaree D, Gallezot J, Lin S, Nabulsi N, Williams W, McCarthy T, Ding Y, Huang Y, Carson R. A correction algorithm for carryover of tracer in paired C-11 studies: Application to the H-3 receptor antagonist [C-11]GSK189254. NeuroImage 2010, 52: s166. DOI: 10.1016/j.neuroimage.2010.04.135.
Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: Test–retest reproducibility and gender differencesNormandin M, Zheng M, Ropchan J, Labaree D, Najafzadeh S, Hull R, Qian W, Henry S, Williams W, Carson R, Huang Y, Neumeister A. Imaging the cannabinoid CB1 receptor in humans with [11C]OMAR: Test–retest reproducibility and gender differences. NeuroImage 2010, 52: s82-s83. DOI: 10.1016/j.neuroimage.2010.04.066.
PET evaluation of the TSPO ligands [F-18]FEPPA, [F-18]PRB06, and [F-18]PBR111 in nonhuman primateCarson R, Weinzimmer D, Koren A, Alagille D, Fowles K, Ashworth S, Seibyl J, Katsifis A, Gunn R, Rabiner E, Tang S, Tamagnan G. PET evaluation of the TSPO ligands [F-18]FEPPA, [F-18]PRB06, and [F-18]PBR111 in nonhuman primate. NeuroImage 2010, 52: s147. DOI: 10.1016/j.neuroimage.2010.04.121.
Awake nonhuman primate brain PET imaging without head restraintCarson R, Sandiego C, Mulnix T, Jin X, Fowles K, Liddie S, Ford S, Weinzimmer D, Campbell D, Abbott A, Laruelle M, Gunn R, Ashburner S, Rabiner E, Castner S, Williams G. Awake nonhuman primate brain PET imaging without head restraint. NeuroImage 2010, 52: s18. DOI: 10.1016/j.neuroimage.2010.04.203.
Kinetic analysis of the kappa agonist tracer [11C]GR103545 in healthy controlsTomasi G, Zheng M, Ropchan J, Weinzimmer D, Linn S, Nabulsi N, Williams W, Ding Y, Jacobsen L, Huang H, Carson R. Kinetic analysis of the kappa agonist tracer [11C]GR103545 in healthy controls. NeuroImage 2010, 52: s172. DOI: 10.1016/j.neuroimage.2010.04.140.
Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humansNormandin M, Weinzimmer D, Ropchan J, Labaree D, Lin K, Mason N, Carson R, D'Souza D, Neumeister A, Huang Y. Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humans. NeuroImage 2010, 52: s13. DOI: 10.1016/j.neuroimage.2010.04.198.
Kinetic modeling of the mGluR5 tracer [18F]F-FPEB in humansSullivan J, Lim K, Labree D, Lin S, McCarthy T, Seibyl J, Tamagnan G, Huang Y, Carson R, Morris E, Ding Y. Kinetic modeling of the mGluR5 tracer [18F]F-FPEB in humans. NeuroImage 2010, 52: s169-s170. DOI: 10.1016/j.neuroimage.2010.04.138.
Evaluation of a 3D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scannerYao R, Ramachandra R, Panse A, Balla D, Yan J, Carson R. Evaluation of a 3D point spread function (PSF) model derived from Monte Carlo simulation for a small animal PET scanner. Proceedings Of SPIE 2010, 7622: 76220w-76220w-8. DOI: 10.1117/12.845323.
Initial Evaluation of Direct 4D Parametric Reconstruction with Human PET DataYan J, Planeta-Wilson B, Gallezot JD, Carson RE. Initial Evaluation of Direct 4D Parametric Reconstruction with Human PET Data. 2011 IEEE Nuclear Science Symposium Conference Record 2009, 2009: 2503-2506. PMID: 21278923, PMCID: PMC3030204, DOI: 10.1109/nssmic.2009.5402049.
Accuracy of Head Motion Compensation for the HRRT: Comparison of MethodsJin X, Mulnix T, Planeta-Wilson B, Gallezot JD, Carson RE. Accuracy of Head Motion Compensation for the HRRT: Comparison of Methods. 2011 IEEE Nuclear Science Symposium Conference Record 2009, 2009: 3199-3202. PMID: 20607125, PMCID: PMC2895273, DOI: 10.1109/nssmic.2009.5401706.
Kinetic Modeling of the Serotonin 5-HT1B Receptor Radioligand [11C]P943 in HumansGallezot JD, Nabulsi N, Neumeister A, Planeta-Wilson B, Williams WA, Singhal T, Kim S, Maguire RP, McCarthy T, Frost JJ, Huang Y, Ding YS, Carson RE. Kinetic Modeling of the Serotonin 5-HT1B Receptor Radioligand [11C]P943 in Humans. Cerebrovascular And Brain Metabolism Reviews 2009, 30: 196-210. PMID: 19773803, PMCID: PMC2949107, DOI: 10.1038/jcbfm.2009.195.
Gender differences in 5HT1A receptor density and affinity measured by [18F]FPWAY and PET in juvenile rhesus monkeysChefer S, Spinelli S, Carson R, Jagoda E, Suomi S, Stein E. Gender differences in 5HT1A receptor density and affinity measured by [18F]FPWAY and PET in juvenile rhesus monkeys. NeuroImage 2008, 41: t147. DOI: 10.1016/j.neuroimage.2008.04.115.
Evaluation of [11C]MRB for receptor occupancy studies of norepinephrine transportersGallezot J, Weinzimmer D, Nabulsi N, Lin S, Fowles K, Maguire P, Carson R, Ding Y. Evaluation of [11C]MRB for receptor occupancy studies of norepinephrine transporters. NeuroImage 2008, 41: t49. DOI: 10.1016/j.neuroimage.2008.04.223.
Relationship between serotonin-1A binding and HPA axis in subjects with major depression and healthy controlsCarlson P, Bain E, Tinsley R, Nugent A, Carson R, Luckenbaugh D, Kling M, Gold P, Remaley A, Drevets W. Relationship between serotonin-1A binding and HPA axis in subjects with major depression and healthy controls. NeuroImage 2008, 41: t146. DOI: 10.1016/j.neuroimage.2008.04.114.
PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injuryHuang Y, Nabulsi N, Weinzimmer D, Fung E, Ropchan J, Labaree D, Wang X, Gould G, Frost J, Carson R, Strittmatter S. PET Imaging of serotonin transporter as a biomarker for axon damage and regeneration in spinal cord injury. NeuroImage 2008, 41: t154. DOI: 10.1016/j.neuroimage.2008.04.122.
First in human evaluation of [11C]AFM, a novel PET tracer for the serotonin transporterWilliams W, Neumeister A, Nabulsi N, Ropchan J, Labaree D, Planeta-Wilson B, Najafzadeh S, Carson R, Huang Y. First in human evaluation of [11C]AFM, a novel PET tracer for the serotonin transporter. NeuroImage 2008, 41: t42. DOI: 10.1016/j.neuroimage.2008.04.216.
PET imaging of norepinephrine transporter in cocaine abuser using (S,S)-[11C]MRBSinghal T, Planeta-Wilson B, Gallezot J, Henry S, Nabulsi N, Labaree D, Ropchan J, Carson R, Neumeister A, Malison R, Ding Y. PET imaging of norepinephrine transporter in cocaine abuser using (S,S)-[11C]MRB. NeuroImage 2008, 41: t195. DOI: 10.1016/j.neuroimage.2008.04.162.
In vivo Scatchard analysis of bolus/infusion 5-HT1B studies with [11C]P943: Comparison between SRTM and equilibrium methodsTomasi G, Nabulsi N, Weinzimmer D, Sandiego C, Gallezot J, Wang E, McLean S, Huang Y, Ding Y, Carson R. In vivo Scatchard analysis of bolus/infusion 5-HT1B studies with [11C]P943: Comparison between SRTM and equilibrium methods. NeuroImage 2008, 41: t16. DOI: 10.1016/j.neuroimage.2008.04.190.
Lack of dopamine release in response to monetary reward in depressed patients: A [11C]raclopride PET studyMartin-Soelch C, Szczepanik J, Barhaghi K, Rollis D, Cannon D, Nugent A, Herscovitch P, Carson R, Drevets W. Lack of dopamine release in response to monetary reward in depressed patients: A [11C]raclopride PET study. NeuroImage 2008, 41: t56. DOI: 10.1016/j.neuroimage.2008.04.230.
Serotonin-1B receptor imaging in PTSDNeumeister A, Czermak C, Henry S, Planeta-Wilson B, Huang H, Ding Y, Krystal J, Nabulsi N, Gallezot J, Carson R. Serotonin-1B receptor imaging in PTSD. NeuroImage 2008, 41: t163. DOI: 10.1016/j.neuroimage.2008.04.130.
Count-Rate Dependent Component-Based Normalization for the HRRTRodriguez M, Liow J, Thada S, Sibomana M, Chelikani S, Mulnix T, Johnson C, Michel C, Barker W, Carson R. Count-Rate Dependent Component-Based Normalization for the HRRT. IEEE Transactions On Nuclear Science 2007, 54: 486-495. DOI: 10.1109/tns.2007.897824.
Antiepileptic Drugs Do Not Affect 5-HT1A Receptor Binding Measured by Positron Emission TopographyTHEODORE W, GIOVACCHINI G, BAGIC A, HERSCOVITCH P, CARSON R. Antiepileptic Drugs Do Not Affect 5-HT1A Receptor Binding Measured by Positron Emission Topography. Neurotherapeutics 2006, 3: 410-410. DOI: 10.1016/j.nurx.2006.05.019.
Modeling of ligand–receptor interactions for a nicotinic agonist: Is it possible to discriminate multiple affinity states in vivo with PET?Gallezot J, Delforge J, Carson R, Grégoire M. Modeling of ligand–receptor interactions for a nicotinic agonist: Is it possible to discriminate multiple affinity states in vivo with PET? NeuroImage 2006, 31: t104-t105. DOI: 10.1016/j.neuroimage.2006.04.091.
Serotonin-1A receptor binding in depression: Correlates with interleukin-6 and the hypothalamic–pituitary–adrenal axisCarlson P, Bain E, Tinsley R, Nugent A, Carson R, Luckenbaugh D, Alesci S, Kling M, Gold P, Drevets W. Serotonin-1A receptor binding in depression: Correlates with interleukin-6 and the hypothalamic–pituitary–adrenal axis. NeuroImage 2006, 31: t173. DOI: 10.1016/j.neuroimage.2006.04.156.
Muscarinic cholinergic2 receptor binding in bipolar disorder: Relation to saliency of affective-wordsCannon D, Nugent A, Erickson K, Carson R, Eckelman W, Kiesewetter D, Bain E, Gandhi S, Solorio G, Charney D, Drevets W. Muscarinic cholinergic2 receptor binding in bipolar disorder: Relation to saliency of affective-words. Cerebrovascular And Brain Metabolism Reviews 2005, 25: s420-s420. DOI: 10.1038/sj.jcbfm.9591524.0420.
[P‐103]: Imaging neuroinflammation in Alzheimer disease with [1–11C] arachidonic acid and positron emission tomographyRapoport S, Carson R, Bhattacharjee A, Schapiro M, Herscovitch P, Eckelman W, Esposito G. [P‐103]: Imaging neuroinflammation in Alzheimer disease with [1–11C] arachidonic acid and positron emission tomography. Alzheimer's & Dementia 2005, 1: s41-s41. DOI: 10.1016/j.jalz.2005.06.177.
Tracer Kinetic Modeling in PETCarson R. Tracer Kinetic Modeling in PET. 2005, 127-159. DOI: 10.1007/1-84628-007-9_6.
Tracer Kinetic Parametric Imaging in PetCarson R. Tracer Kinetic Parametric Imaging in Pet. 2004, 2: 611-615. DOI: 10.1109/isbi.2004.1398612.
Randoms Estimation for List-mode Reconstruction for the ECAT HRRTBarker W, Liow J, Rodriguez M, Thada S, Iano-Fletcher A, Lenox M, Michel C, Johnson C, Carson R. Randoms Estimation for List-mode Reconstruction for the ECAT HRRT. 2004, 6: 3510-3513. DOI: 10.1109/nssmic.2004.1466643.
Software Architecture of the MOLAR-HRRT Reconstruction EngineJohnson C, Thada S, Rodriguez M, Zhao Y, Iano-Fletcher A, Liow J, Barker W, Martino R, Carson R. Software Architecture of the MOLAR-HRRT Reconstruction Engine. 2004, 6: 3956-3960. DOI: 10.1109/nssmic.2004.1466744.
Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human BrainIchise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, Suhara T, Suzuki K, Innis RB, Carson RE. Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain. Cerebrovascular And Brain Metabolism Reviews 2003, 23: 1096-1112. PMID: 12973026, DOI: 10.1097/01.wcb.0000085441.37552.ca.
Brain Uptake of the Acid Metabolites of F-18–Labeled WAY 100635 AnalogsCarson R, Wu Y, Lang L, Ma Y, Der M, Herscovitch P, Eckelman W. Brain Uptake of the Acid Metabolites of F-18–Labeled WAY 100635 Analogs. Cerebrovascular And Brain Metabolism Reviews 2003, 23: 249-260. DOI: 10.1097/00004647-200302000-00012.
Design of a motion-compensation OSEM List-mode Algorithm for Resolution-Recovery Reconstruction of the HRRTCarson RE, Barker WC, Liow J-S, Adler S, Johnson CA, Design of a motion-compensation OSEM List-mode Algorithm for Resolution-Recovery Reconstruction of the HRRT Conf Record IEEE Nuclear Science Symposium and Medical Imaging Conference. Portland, OR, 5: 3281-3285, 2003
Design of a Motion-Compensation OSEM List-mode Algorithm for Resolution-Recovery Reconstruction for the HRRTCarson R, Barker W, Liow J, Johnson C. Design of a Motion-Compensation OSEM List-mode Algorithm for Resolution-Recovery Reconstruction for the HRRT. 2003, 5: 3281-3285. DOI: 10.1109/nssmic.2003.1352597.
Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional ImagingWu Y, Carson R. Noise Reduction in the Simplified Reference Tissue Model for Neuroreceptor Functional Imaging. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1440-1452. DOI: 10.1097/00004647-200212000-00004.
Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission TomographyGiovacchini G, Chang M, Channing M, Toczek M, Mason A, Bokde A, Connolly C, Vuong B, Ma Y, Der M, Doudet D, Herscovitch P, Eckelman W, Rapoport S, Carson R. Brain Incorporation of [11C]Arachidonic Acid in Young Healthy Humans Measured With Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1453-1462. DOI: 10.1097/00004647-200212000-00006.
Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression AnalysisIchise M, Toyama H, Innis RB, Carson RE. Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1271-1281. PMID: 12368666, DOI: 10.1097/01.wcb.0000038000.34930.4e.
Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression AnalysisIchise M, Toyama H, Innis R, Carson R. Strategies to Improve Neuroreceptor Parameter Estimation by Linear Regression Analysis. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1271-1281. DOI: 10.1097/00004647-200210000-00015.
Scatchard Analysis with Bolus/Infusion Administration of [11C]RacloprideCarson R, Channing M, Der M, Herscovitch P, Eckelman W. Scatchard Analysis with Bolus/Infusion Administration of [11C]Raclopride. 2002, 63-69. DOI: 10.1016/b978-012636651-8/50012-x.
Presynaptic dopamine function and cognitive activation in schizophreniaMeyer-Lindenberg A, Miletich R, Kohn P, Esposito G, Carson R, Quarantelli M, Weinberger D, Berman K. Presynaptic dopamine function and cognitive activation in schizophrenia. NeuroImage 2001, 13: 1072. DOI: 10.1016/s1053-8119(01)92402-4.
Improved Quantification for Tc-94m PET ImagingBarker W, Szajek L, Green S, Carson R. Improved Quantification for Tc-94m PET Imaging. IEEE Transactions On Nuclear Science 2001, 48: 739. DOI: 10.1109/23.940156.
Noninvasive Estimation of the Aorta Input Function for Measurement of Tumor Blood Flow with [15O]WaterWatabe H, Channing M, Riddell C, Jousse F, Libutti S, Carrasquillo J, Bacharach S, Carson R. Noninvasive Estimation of the Aorta Input Function for Measurement of Tumor Blood Flow with [15O]Water. IEEE Transactions On Medical Imaging 2001, 20: 164-174. PMID: 11341707, DOI: 10.1109/42.918468.
Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studiesSmith M, Daube‐Witherspoon M, Plascjak P, Szajek L, Carson R, Everett J, Green S, Territo P, Balaban R, Bacharach S, Eckelman W. Device‐dependent activity estimation and decay correction of radionuclide mixtures with application to Tc‐94m PET studies. Medical Physics 2001, 28: 36-45. PMID: 11213920, DOI: 10.1118/1.1333411.
Amphetamine-Induced Dopamine ReleaseCarson R, Channing M, Vuong B, Watabe H, Herscovitch P, Eckelman W. Amphetamine-Induced Dopamine Release. 2001, 205-209. DOI: 10.1016/b978-012285751-5/50034-x.
[α-11C]Methyl-l-tryptophan in Anesthetized Rhesus MonkeysShoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. [α-11C]Methyl-l-tryptophan in Anesthetized Rhesus Monkeys. 2001, 229-235. DOI: 10.1016/b978-012285751-5/50037-5.
Pet physiological measurements using constant infusionCarson R. Pet physiological measurements using constant infusion. Nuclear Medicine And Biology 2000, 27: 657-660. PMID: 11091108, DOI: 10.1016/s0969-8051(00)00138-4.
Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissuresCohen R, Carson R, Saunders R, Doudet D. Opiate receptor avidity is increased in rhesus monkeys following unilateral optic tract lesion combined with transections of corpus callosum and hippocampal and anterior commissures. Brain Research 2000, 879: 1-6. PMID: 11010998, DOI: 10.1016/s0006-8993(00)02528-2.
Does Labeled α-Methyl-L-Tryptophan Image ONLY Blood–Brain Barrier Transport of Tryptophan?Shoaf S, Carson R, Herscovitch P, Eckelman W. Does Labeled α-Methyl-L-Tryptophan Image ONLY Blood–Brain Barrier Transport of Tryptophan? Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1511. DOI: 10.1097/00004647-200010000-00014.
Opiate receptor avidity in the thalamus is sexually dimorphic in the elderlyCohen R, Carson R, Sunderl T. Opiate receptor avidity in the thalamus is sexually dimorphic in the elderly. Synapse 2000, 38: 226-229. PMID: 11018796, DOI: 10.1002/1098-2396(200011)38:2<226::aid-syn13>3.0.co;2-#.
PET evaluation of [18F]FCWAY, an analog of the 5-HT1A receptor antagonist, WAY-100635Carson R, Lang L, Watabe H, Der M, Adams H, Jagoda E, Herscovitch P, Eckelman W. PET evaluation of [18F]FCWAY, an analog of the 5-HT1A receptor antagonist, WAY-100635. Nuclear Medicine And Biology 2000, 27: 493-497. PMID: 10962257, DOI: 10.1016/s0969-8051(00)00118-9.
Kinetic Analysis of the 5-HT2A Ligand [11C]MDL 100,907Watabe H, Channing M, Der M, Adams H, Jagoda E, Herscovitch P, Eckelman W, Carson R. Kinetic Analysis of the 5-HT2A Ligand [11C]MDL 100,907. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 899-909. PMID: 10894173, DOI: 10.1097/00004647-200006000-00002.
368. Muscarinic 2 receptors in cognitively normal young and old volunteersPodruchny T, Connolly C, Kiesewetter D, Carson R, Eckelman W, Cohen R, Sunderland T. 368. Muscarinic 2 receptors in cognitively normal young and old volunteers. Biological Psychiatry 2000, 47: s111. DOI: 10.1016/s0006-3223(00)00632-6.
Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations.Watabe H, Endres CJ, Breier A, Schmall B, Eckelman WC, Carson RE. Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations. Journal Of Nuclear Medicine 2000, 41: 522-30. PMID: 10716328.
The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled TracerShoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 244-252. PMID: 10698060, DOI: 10.1097/00004647-200002000-00004.
Synthesis and evaluation of an 18F analog of forskolin for imaging adenylyl cyclaseKiesewetter D, Sassaman M, Robbins J, Jagoda E, Carson R, Appel N, Sutkowski E, Herscovitch P, Braun A, Eckelman W. Synthesis and evaluation of an 18F analog of forskolin for imaging adenylyl cyclase. Journal Of Fluorine Chemistry 2000, 101: 297-304. DOI: 10.1016/s0022-1139(99)00174-8.
Performance characteristics of the 3-D OSEM algorithm in the reconstruction of small animal PET imagesYao R, Seidel J, Johnson CA, Daube-Witherspoon ME, Green MV, Carson RE. Performance characteristics of the 3-D OSEM algorithm in the reconstruction of small animal PET images. IEEE Transactions On Medical Imaging 2000, 19: 798-804. PMID: 11055803, DOI: 10.1109/42.876305.
Improved quantification for Tc-94 m PET imagingBarker W, Szajek L, Green S, Carson R. Improved quantification for Tc-94 m PET imaging. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 2: 13/113-13/116 vol.2. DOI: 10.1109/nssmic.2000.950002.
Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation StudiesBeason-Held L, Desmond R, Herscovitch P, Carson R. Bolus Injection Versus Slow Infusion of [15O]Water for Positron Emission Tomography Activation Studies. Cerebrovascular And Brain Metabolism Reviews 1999, 19: 843-852. PMID: 10458591, DOI: 10.1097/00004647-199908000-00003.
Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTPCohen R, Carson R, Wyatt R, Doudet D. Opiate receptor avidity is reduced bilaterally in rhesus monkeys unilaterally lesioned with MPTP. Synapse 1999, 33: 282-288. PMID: 10421709, DOI: 10.1002/(sici)1098-2396(19990915)33:4<282::aid-syn5>3.0.co;2-5.
Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor LigandsEndres C, Carson R. Assessment of Dynamic Neurotransmitter Changes With Bolus or Infusion Delivery of Neuroreceptor Ligands. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1196-1210. PMID: 9809509, DOI: 10.1097/00004647-199811000-00006.
Muscarinic Cholinergic Receptor Measurements With [18F]FP-TZTP: Control and Competition StudiesCarson R, Kiesewetter D, Jagoda E, Der M, Herscovitch P, Eckelman W. Muscarinic Cholinergic Receptor Measurements With [18F]FP-TZTP: Control and Competition Studies. Cerebrovascular And Brain Metabolism Reviews 1998, 18: 1130-1142. PMID: 9778190, DOI: 10.1097/00004647-199810000-00010.
Noise characteristics of 3-D and 2-D PET imagesPajevic S, Daube-Witherspoon ME, Bacharach SL, Carson RE. Noise characteristics of 3-D and 2-D PET images. IEEE Transactions On Medical Imaging 1998, 17: 9-23. PMID: 9617904, DOI: 10.1109/42.668691.
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study.Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P, Selbie S, Belenky G, Herscovitch P. Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 1997, 120: 1173-1197. PMID: 9236630, DOI: 10.1093/brain/120.7.1173.
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography methodBreier A, Su T, Saunders R, Carson RE, Kolachana BS, de Bartolomeis A, Weinberger DR, Weisenfeld N, Malhotra AK, Eckelman WC, Pickar D. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2569-2574. PMID: 9122236, PMCID: PMC20129, DOI: 10.1073/pnas.94.6.2569.
Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition modelSastry S, Carson RE. Multimodality Bayesian algorithm for image reconstruction in positron emission tomography: a tissue composition model. IEEE Transactions On Medical Imaging 1997, 16: 750-761. PMID: 9533576, DOI: 10.1109/42.650872.
Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography studyBerman K, Ostrem J, Randolph C, Gold J, Goldberg T, Coppola R, Carson R, Herscovitch P, Weinberger D. Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study. Neuropsychologia 1995, 33: 1027-1046. PMID: 8524452, DOI: 10.1016/0028-3932(95)00035-2.
A system for the 3D reconstruction of retracted-septa PET data using the EM algorithmJohnson C, Yan Y, Carson R, Martino R, Daube-Witherspoon M. A system for the 3D reconstruction of retracted-septa PET data using the EM algorithm. 1995, 3: 1325-1329 vol.3. DOI: 10.1109/nssmic.1994.474573.
Multimodality Bayesian algorithm for image reconstruction in positron emission tomographySastry S, VanMeter J, Carson R. Multimodality Bayesian algorithm for image reconstruction in positron emission tomography. 1995, 3: 1694-1698 vol.3. DOI: 10.1109/nssmic.1995.501912.
Precision and accuracy of regional radioactivity quantitation using the maximum likelihood EM reconstruction algorithmCarson RE, Yan Y, Chodkowski B, Yap TK, Daube-Witherspoon ME. Precision and accuracy of regional radioactivity quantitation using the maximum likelihood EM reconstruction algorithm. IEEE Transactions On Medical Imaging 1994, 13: 526-537. PMID: 18218528, DOI: 10.1109/42.310884.
Analysis of Covariance in Statistical Parametric MappingClark C, Carson R. Analysis of Covariance in Statistical Parametric Mapping. Cerebrovascular And Brain Metabolism Reviews 1993, 13: 1038-1038. PMID: 8408314, DOI: 10.1038/jcbfm.1993.132.
An approximation formula for the variance of PET region-of-interest valuesCarson RE, Yan Y, Daube-Witherspoon ME, Freedman N, Bacharach SL, Herscovitch P. An approximation formula for the variance of PET region-of-interest values. IEEE Transactions On Medical Imaging 1993, 12: 240-250. PMID: 18218411, DOI: 10.1109/42.232252.
PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxyTheodore W, Carson R, Andreasen P, Zametkin A, Blasberg R, Leiderman D, Rice K, Newman A, Channing M, Dunn B, Simpson N, Herscovitch P. PET imaging of opiate receptor binding in human epilepsy using [18F]cyclofoxy. Epilepsy Research 1992, 13: 129-139. PMID: 1334456, DOI: 10.1016/0920-1211(92)90068-5.
Dissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission TomographyGrady C, Haxby J, Horwitz B, Schapiro M, Rapoport S, Ungerleider L, Mishkin M, Carson R, Herscovitch P. Dissociation of Object and Spatial Vision in Human Extrastriate Cortex: Age-Related Changes in Activation of Regional Cerebral Blood Flow Measured with [15 O]Water and Positron Emission Tomography. Journal Of Cognitive Neuroscience 1992, 4: 23-34. PMID: 23967855, DOI: 10.1162/jocn.1992.4.1.23.
The development and application of mathematical models in nuclear medicine.Carson RE. The development and application of mathematical models in nuclear medicine. Journal Of Nuclear Medicine 1991, 32: 2206-8. PMID: 1744704.
Precision and Accuracy Considerations of Physiological Quantitation in PETCarson R. Precision and Accuracy Considerations of Physiological Quantitation in PET. Cerebrovascular And Brain Metabolism Reviews 1991, 11: a45-a50. PMID: 1997487, DOI: 10.1038/jcbfm.1991.36.
Dissociation of object and spatial visual processing pathways in human extrastriate cortex.Haxby JV, Grady CL, Horwitz B, Ungerleider LG, Mishkin M, Carson RE, Herscovitch P, Schapiro MB, Rapoport SI. Dissociation of object and spatial visual processing pathways in human extrastriate cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 1621-1625. PMID: 2000370, PMCID: PMC51076, DOI: 10.1073/pnas.88.5.1621.
A method for postinjection PET transmission measurements with a rotating source.Carson RE, Daube-Witherspoon ME, Green MV. A method for postinjection PET transmission measurements with a rotating source. Journal Of Nuclear Medicine 1988, 29: 1558-67. PMID: 3261786.
Post-injection transmission attenuation measurements for PETDaube-Witherspoon M, Carson R, Green M. Post-injection transmission attenuation measurements for PET. IEEE Transactions On Nuclear Science 1988, 35: 757-761. DOI: 10.1109/23.12827.
A Maximum Likelihood Method for Region-of-Interest Evaluation in Emission TomographyCarson R. A Maximum Likelihood Method for Region-of-Interest Evaluation in Emission Tomography. Journal Of Computer Assisted Tomography 1986, 10: 654-663. PMID: 3488338, DOI: 10.1097/00004728-198607000-00021.
Weighted Integration Method for Local Cerebral Blood Flow Measurements with Positron Emission TomographyCarson R, Huang S, Green M. Weighted Integration Method for Local Cerebral Blood Flow Measurements with Positron Emission Tomography. Cerebrovascular And Brain Metabolism Reviews 1986, 6: 245-258. PMID: 3485644, DOI: 10.1038/jcbfm.1986.38.
Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems.Huang SC, Schwaiger M, Carson RE, Carson J, Hansen H, Selin C, Hoffman EJ, MacDonald N, Schelbert HR, Phelps ME. Quantitative measurement of myocardial blood flow with oxygen-15 water and positron computed tomography: an assessment of potential and problems. Journal Of Nuclear Medicine 1985, 26: 616-25. PMID: 3873525.
Alternative Statistical Models for the Examination of Clinical Positron Emission Tomography/Fluorodeoxyglucose DataClark C, Carson R, Kessler R, Margolin R, Buchsbaum M, DeLisi L, King C, Cohen R. Alternative Statistical Models for the Examination of Clinical Positron Emission Tomography/Fluorodeoxyglucose Data. Cerebrovascular And Brain Metabolism Reviews 1985, 5: 142-150. PMID: 3871782, DOI: 10.1038/jcbfm.1985.18.
Comment: The EM Parametric Image Reconstruction AlgorithmCarson R, Lange K. Comment: The EM Parametric Image Reconstruction Algorithm. Journal Of The American Statistical Association 1985, 80: 20-22. DOI: 10.1080/01621459.1985.10477120.
A Statistical Model for Positron Emission Tomography: CommentCarson R, Lange K. A Statistical Model for Positron Emission Tomography: Comment. Journal Of The American Statistical Association 1985, 80: 20. DOI: 10.2307/2288031.
Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-WaterHuang S, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, Phelps ME. Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and 15O-Water. Cerebrovascular And Brain Metabolism Reviews 1983, 3: 141-153. PMID: 6601663, DOI: 10.1038/jcbfm.1983.21.
Measurement of Local Blood Flow and Distribution Volume with Short-Lived Isotopes: A General Input TechniqueHuang S, Carson R, Phelps M. Measurement of Local Blood Flow and Distribution Volume with Short-Lived Isotopes: A General Input Technique. Cerebrovascular And Brain Metabolism Reviews 1982, 2: 99-108. PMID: 6977546, DOI: 10.1038/jcbfm.1982.11.
A BOUNDARY METHOD FOR ATTENUATION CORRECTION IN POSITRON COMPUTED TOMOGRAPHYHuang S, Carson R, Phelps M, Hoffman E, Schelbert H, Kuhl D. A BOUNDARY METHOD FOR ATTENUATION CORRECTION IN POSITRON COMPUTED TOMOGRAPHY. Journal Of Computer Assisted Tomography 1981, 5: 950. DOI: 10.1097/00004728-198112000-00087.
Moment computations for subcritical branching processesLange K, Boehnke M, Carson R. Moment computations for subcritical branching processes. Journal Of Applied Probability 1981, 18: 52-64. DOI: 10.1017/s0021900200097606.

Clinical Trials

Conditions	Study Title
Diseases of the Nervous System	Study of Safety and of the Mechanism of BLZ945 in ALS Patients
Alzheimer's Disease; Mental Health & Behavioral Research	Ketamine for the Treatment of Depression in Parkinson's Disease
COVID-19 Inpatient; COVID-19 Outpatient; Diseases of the Nervous System; HIV/AIDS; Infectious Diseases	HIV Associated Reservoirs and Comorbidities (The HARC Plus Study)
Child Development & Autism	PET Imaging Study for Young Adults with ASD
Diseases of the Nervous System	Imaging the Dopamine Transporter in Parkinson's Disease
Diseases of the Nervous System; Mental Health & Behavioral Research	Examination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral Research	Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD
Diseases of the Nervous System	Imaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Mental Health & Behavioral Research	Imaging mGluR5 and synaptic density in psychiatric disorders
Mental Health & Behavioral Research	Imaging SV2A in mood disorders
Diseases of the Nervous System; Mental Health & Behavioral Research	SV2A PET Imaging in Healthy Subjects and Epilepsy Patients
Addictive Behaviors; Diseases of the Nervous System; Genetics - Adult; Mental Health & Behavioral Research	Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Diseases of the Nervous System	PET and MRI in OCD and/or Tic disorders
Mental Health & Behavioral Research	Studying the Adult Brain
Larynx; Lip, Oral Cavity and Pharynx; Phase I	Pilot Study of Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases

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Richard Carson, PhD

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