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Ming-Kai Chen, MD, PhD

Associate Professor of Radiology and Biomedical Imaging; Co-Medical Director, Yale University PET Center

Research & Publications
Biography
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Selected Publications

Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokersZakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, DOI: 10.1016/j.bbi.2022.08.016.
Imaging of Synaptic Density in Neurodegenerative Disorders.Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, Matuskey D, Finnema SJ. Imaging of Synaptic Density in Neurodegenerative Disorders. Journal Of Nuclear Medicine 2022, 63: 60s-67s. PMID: 35649655, DOI: 10.2967/jnumed.121.263201.
Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-FluciclovineToyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-Fluciclovine European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3086-3097. PMID: 35277742, DOI: 10.1007/s00259-022-05748-2.
Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐JMecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, Lipior S, Diepenbrock NG, Chen M, Naganawa M, Toyonaga T, Nabulsi NB, Wyk B, Wyk B, Arnsten AFT, Huang Y, Carson RE, Dyck C, Dyck C. Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB‐J Alzheimer's & Dementia 2022, 18: 2527-2536. PMID: 35174954, PMCID: PMC9381645, DOI: 10.1002/alz.12582.
Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment responseZakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine patch alters patterns of cigarette smoking-induced dopamine release: Patterns relate to biomarkers associated with treatment response Nicotine & Tobacco Research 2022, 24: ntac026-. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.
PET Image Denoising Using a Deep-Learning Method for Extremely Obese PatientsLiu H, Yousefi H, Mirian N, Lin M, Menard D, Gregory M, Aboian M, Boustani A, Chen M, Saperstein L, Pucar D, Kulon M, Liu C. PET Image Denoising Using a Deep-Learning Method for Extremely Obese Patients IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 766-770. DOI: 10.1109/trpms.2021.3131999.
Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's diseaseMecca AP, Chen MK, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Banks ER, Ni GS, Rogers K, Gallezot JD, Ropchan J, Emery PR, Nabulsi NB, Vander Wyk BC, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Association of entorhinal cortical tau deposition and hippocampal synaptic density in older individuals with normal cognition and early Alzheimer's disease Neurobiology Of Aging 2021, 111: 44-53. PMID: 34963063, PMCID: PMC8761170, DOI: 10.1016/j.neurobiolaging.2021.11.004.
Determining the minimal ultra-low dose CT for reliable attenuation correction of 18F-FDG PET-CT: a phantom study.Cheng D, Ghita M, Menard D, Chen MK. Determining the minimal ultra-low dose CT for reliable attenuation correction of 18F-FDG PET-CT: a phantom study. Journal Of Nuclear Medicine Technology 2021, 50: 126-131. PMID: 34750234, DOI: 10.2967/jnmt.121.262943.
Super-resolution PET Brain Imaging using Deep LearningRen S, Liu J, Xie H, Toyonaga T, Mirian N, Chen M, Aboian M, Carson R, Liu C. Super-resolution PET Brain Imaging using Deep Learning 2021, 00: 1-6. DOI: 10.1109/nss/mic44867.2021.9875548.
Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial NetworkZhou B, Wang R, Chen M, Mecca A, O’Dell R, Van Dyck C, Carson R, Duncan J, Liu C. Synthesizing Multi-tracer PET Images for Alzheimer’s Disease Patients Using a 3D Unified Anatomy-Aware Cyclic Adversarial Network 2021, 12906: 34-43. DOI: 10.1007/978-3-030-87231-1_4.
Generation of parametric Ki images for FDG PET using two 5‐min scansWu J, Liu H, Ye Q, Gallezot J, Naganawa M, Miao T, Lu Y, Chen M, Esserman DA, Kyriakides TC, Carson RE, Liu C. Generation of parametric Ki images for FDG PET using two 5‐min scans Medical Physics 2021, 48: 5219-5231. PMID: 34287939, DOI: 10.1002/mp.15113.
Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learningWang R, Liu H, Toyonaga T, Shi L, Wu J, Onofrey JA, Tsai Y, Naganawa M, Ma T, Liu Y, Chen M, Mecca AP, O’Dell R, Dyck C, Carson RE, Liu C. Generation of synthetic PET images of synaptic density and amyloid from 18F‐FDG images using deep learning Medical Physics 2021, 48: 5115-5129. PMID: 34224153, PMCID: PMC8455448, DOI: 10.1002/mp.15073.
Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's diseaseLu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling studyChen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O’Dell R, McDonald JW, Michalak HR, Wyk B, Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer’s disease: A tracer kinetic modeling study Cerebrovascular And Brain Metabolism Reviews 2021, 41: 2395-2409. PMID: 33757318, PMCID: PMC8393289, DOI: 10.1177/0271678x211004312.
Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-JO’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.
In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s diseaseMecca A, O'Dell R, Chen M, Naganawa M, Toyonaga T, Godek T, Godek T, Harris J, Harris J, Bartlett H, Bartlett H, Zhao W, Gallezot J, Nabulsi N, Ropchan J, Ye Y, Wyk B, Wyk B, Arnsten A, Huang Y, Carson R, van Dyck C. In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s disease Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037791.
Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PETNaganawa M, Gallezot JD, Shah V, Mulnix T, Young C, Dias M, Chen MK, Smith AM, Carson RE. Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET EJNMMI Physics 2020, 7: 67. PMID: 33226522, PMCID: PMC7683759, DOI: 10.1186/s40658-020-00330-x.
PET Imaging of Synaptic Vesicle Protein 2AFinnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography studyFinnema SJ, Toyonaga T, Detyniecki K, Chen M, Dias M, Wang Q, Lin S, Lin S, Naganawa M, Gallezot J, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study Epilepsia 2020, 61: 2183-2193. PMID: 32944949, DOI: 10.1111/epi.16653.
Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation taskSmart K, Liu H, Matuskey D, Chen MK, Torres K, Nabulsi N, Labaree D, Ropchan J, Hillmer AT, Huang Y, Carson RE. Binding of the synaptic vesicle radiotracer [11C]UCB-J is unchanged during functional brain activation using a visual stimulation task Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1067-1079. PMID: 32757741, PMCID: PMC8054713, DOI: 10.1177/0271678x20946198.
In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PETMecca AP, Chen M, O'Dell RS, Naganawa M, Toyonaga T, Godek TA, Harris JE, Bartlett HH, Zhao W, Nabulsi NB, Wyk BCV, Varma P, Arnsten AFT, Huang Y, Carson RE, Dyck C, Dyck C. In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET Alzheimer's & Dementia 2020, 16: 974-982. PMID: 32400950, PMCID: PMC7383876, DOI: 10.1002/alz.12097.
PET imaging of mGluR5 in Alzheimer’s diseaseMecca AP, McDonald JW, Michalak HR, Godek TA, Harris JE, Pugh EA, Kemp EC, Chen MK, Salardini A, Nabulsi NB, Lim K, Huang Y, Carson RE, Strittmatter SM, van Dyck CH. PET imaging of mGluR5 in Alzheimer’s disease Alzheimer's Research & Therapy 2020, 12: 15. PMID: 31954399, PMCID: PMC6969979, DOI: 10.1186/s13195-020-0582-0.
Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRBSanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [11C] MRB International Journal Of Obesity 2019, 44: 964-967. PMID: 31636373, PMCID: PMC7259982, DOI: 10.1038/s41366-019-0471-4.
Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET studyTuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Collste K, Gallezot J, Hillmer A, Huang Y, Huang Y, Höglund C, Höglund C, Johansson J, Johansson J, Jucaite A, Jucaite A, Lampa J, Lampa J, Nabulsi N, Pittman B, Pittman B, Sandiego C, Sandiego C, Stenkrona P, Stenkrona P, Rinne J, Rinne J, Matuskey D, Cervenka S, Cervenka S. Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [11C]PBR28 HRRT PET study European Journal Of Nuclear Medicine And Molecular Imaging 2019, 46: 2329-2338. PMID: 31363804, PMCID: PMC6717599, DOI: 10.1007/s00259-019-04403-7.
Neuroimaging in DementiasMahalingam S, Chen MK. Neuroimaging in Dementias Seminars In Neurology 2019, 39: 188-199. PMID: 30925612, DOI: 10.1055/s-0039-1678580.
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic ImagingChen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging JAMA Neurology 2018, 75: 1215-1224. PMID: 30014145, PMCID: PMC6233853, DOI: 10.1001/jamaneurol.2018.1836.
Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected doseYe Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C. Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static 18F-FDG PET as a function of injected dose Physics In Medicine And Biology 2018, 63: 175015. PMID: 30095083, PMCID: PMC6158045, DOI: 10.1088/1361-6560/aad97f.
P1‐469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASEMecca A, McDonald J, McDonald J, Michalak H, Michalak H, Godek T, Godek T, Harris J, Harris J, Chen M, Nabulsi N, Salardini A, Salardini A, Carson R, Strittmatter S, Dyck C, Dyck C. P1‐469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p501-p503. DOI: 10.1016/j.jalz.2018.06.479.
P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCEChen M, Mecca A, Naganawa M, Finnema S, Finnema S, Toyonaga T, Gallezot J, McDonald J, McDonald J, Michalak H, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C, Dyck C. P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p832-p832. DOI: 10.1016/j.jalz.2018.06.1056.
IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCEMecca A, Chen M, Naganawa M, Finnema S, Finnema S, Toyonaga T, Lin S, Lin S, Gallezot J, McDonald J, McDonald J, Michalak H, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, Dyck C, Dyck C. IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE Alzheimer's & Dementia 2018, 14: p152-p153. DOI: 10.1016/j.jalz.2018.06.2250.
IC‐04‐03: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASEMecca A, McDonald J, McDonald J, Michalak H, Michalak H, Godek T, Godek T, Harris J, Harris J, Chen M, Nabulsi N, Salardini A, Salardini A, Carson R, Strittmatter S, Dyck C, Dyck C. IC‐04‐03: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE Alzheimer's & Dementia 2018, 14: p8-p9. DOI: 10.1016/j.jalz.2018.06.2051.
Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humansFinnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Kinetic evaluation and test–retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans Cerebrovascular And Brain Metabolism Reviews 2017, 38: 2041-2052. PMID: 28792356, PMCID: PMC6259313, DOI: 10.1177/0271678x17724947.
The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitisMorbelli S, Arbizu J, Booij J, Chen MK, Chetelat G, Cross DJ, Djekidel M, Drzezga A, Ekmekcioglu O, Garibotto V, Hesse S, Ishii K, Saraf LJ, Lammertsma AA, Law I, Mathews D, Minoshima S, Mosci K, Pagani M, Pappata S, Silverman DH, Signore A, Van De Giessen E, Villemagne V, Barthel H, on behalf of the European Association of Nuclear Medicine (EANM) and of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). The need of standardization and of large clinical studies in an emerging indication of [18F]FDG PET: the autoimmune encephalitis European Journal Of Nuclear Medicine And Molecular Imaging 2016, 44: 353-357. PMID: 27924371, DOI: 10.1007/s00259-016-3589-9.
Imaging synaptic density in the living human brainFinnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Imaging synaptic density in the living human brain Science Translational Medicine 2016, 8: 348ra96. PMID: 27440727, DOI: 10.1126/scitranslmed.aaf6667.
Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom StudyChen MK, Menard DH, Cheng DW. Determining the Minimal Required Radioactivity of 18F-FDG for Reliable Semiquantification in PET/CT Imaging: A Phantom Study Journal Of Nuclear Medicine Technology 2016, 44: 26-30. PMID: 26769598, DOI: 10.2967/jnmt.115.165258.
11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areasPark E, Gallezot JD, Delgadillo A, Liu S, Planeta B, Lin SF, O’Connor K, Lim K, Lee JY, Chastre A, Chen MK, Seneca N, Leppert D, Huang Y, Carson RE, Pelletier D. 11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas European Journal Of Nuclear Medicine And Molecular Imaging 2015, 42: 1081-1092. PMID: 25833352, DOI: 10.1007/s00259-015-3043-4.
What is the role of dosimetry in patients with advanced thyroid cancer?Chen MK, Cheng DW. What is the role of dosimetry in patients with advanced thyroid cancer? Current Opinion In Oncology 2015, 27: 33-37. PMID: 25319079, DOI: 10.1097/cco.0000000000000145.
Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysisLin S, Labaree D, Chen M, Holden D, Gallezot J, Kapinos M, Teng J, Najafzadeh S, Plisson C, Rabiner EA, Gunn RN, Carson RE, Huang Y. Further evaluation of [11C]MP‐10 as a radiotracer for phosphodiesterase 10A: PET imaging study in rhesus monkeys and brain tissue metabolite analysis Synapse 2014, 69: 86-95. PMID: 25450608, PMCID: PMC4275380, DOI: 10.1002/syn.21792.
Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta).Caporizzo DJ, Kwiatkowski AE, Chen MK, Beck AP, Booth CJ, Zeiss C, Smith PC, Carlson Scholz JA, Wilson SR. Use of (18)F-fluorodeoxyglucose positron emission tomography-computed tomography to aid in diagnosing intestinal adenocarcinoma in 2 rhesus macaques (Macaca mulatta). Comparative Medicine 2014, 64: 211-20. PMID: 24956213, PMCID: PMC4067585.
The Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid CancerChen MK, Yasrebi M, Samii J, Staib LH, Doddamane I, Cheng DW. The Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid Cancer Thyroid 2012, 22: 304-309. PMID: 22300251, DOI: 10.1089/thy.2011.0203.
Recombinant human thyroid-stimulating hormone as an alternative for thyroid hormone withdrawal in thyroid cancer managementChen MK, Doddamane I, Cheng DW. Recombinant human thyroid-stimulating hormone as an alternative for thyroid hormone withdrawal in thyroid cancer management Current Opinion In Oncology 2010, 22: 6-10. PMID: 19844179, DOI: 10.1097/cco.0b013e3283339d5d.
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair.Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair. Pharmacology & Therapeutics 2008, 118: 1-17. PMID: 18374421, PMCID: PMC2453598, DOI: 10.1016/j.pharmthera.2007.12.004.
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.Chen MK, Kuwabara H, Zhou Y, Adams RJ, Brasić JR, McGlothan JL, Verina T, Burton NC, Alexander M, Kumar A, Wong DF, Guilarte TR. VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease. Journal Of Neurochemistry 2008, 105: 78-90. PMID: 17988241, PMCID: PMC4137401, DOI: 10.1111/j.1471-4159.2007.05108.x.
Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects.Guilarte TR, Chen MK. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology 2007, 28: 1147-52. PMID: 17662456, PMCID: PMC2100416, DOI: 10.1016/j.neuro.2007.06.005.
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates.Guilarte TR, Chen MK, McGlothan JL, Verina T, Wong DF, Zhou Y, Alexander M, Rohde CA, Syversen T, Decamp E, Koser AJ, Fritz S, Gonczi H, Anderson DW, Schneider JS. Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Experimental Neurology 2006, 202: 381-90. PMID: 16925997, DOI: 10.1016/j.expneurol.2006.06.015.
Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study.Guilarte TR, McGlothan JL, Degaonkar M, Chen MK, Barker PB, Syversen T, Schneider JS. Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 94: 351-8. PMID: 16968886, DOI: 10.1093/toxsci/kfl106.
An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge.Zhou Y, Chen MK, Endres CJ, Ye W, Brasic JR, Alexander M, Crabb AH, Guilarte TR, Wong DF. An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge. NeuroImage 2006, 33: 550-63. PMID: 16920365, DOI: 10.1016/j.neuroimage.2006.06.038.
Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination.Chen MK, Guilarte TR. Imaging the peripheral benzodiazepine receptor response in central nervous system demyelination and remyelination. Toxicological Sciences : An Official Journal Of The Society Of Toxicology 2006, 91: 532-9. PMID: 16554315, DOI: 10.1093/toxsci/kfj172.
Acute manganese administration alters dopamine transporter levels in the non-human primate striatum.Chen MK, Lee JS, McGlothan JL, Furukawa E, Adams RJ, Alexander M, Wong DF, Guilarte TR. Acute manganese administration alters dopamine transporter levels in the non-human primate striatum. Neurotoxicology 2006, 27: 229-36. PMID: 16325911, DOI: 10.1016/j.neuro.2005.10.008.
In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation.Hardwick MJ, Chen MK, Baidoo K, Pomper MG, Guilarte TR. In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation. Molecular Imaging 2005, 4: 432-8. PMID: 16285905.
A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation.Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Brenneman K, Pili R, Pomper M, Carducci MA, Wagner HN. A new high affinity technetium-99m-bombesin analogue with low abdominal accumulation. Bioconjugate Chemistry 2005, 16: 43-50. PMID: 15656574, DOI: 10.1021/bc049820h.
A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier.Lin KS, Luu A, Baidoo KE, Hashemzadeh-Gargari H, Chen MK, Pili R, Pomper M, Carducci M, Wagner HN. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjugate Chemistry 2004, 15: 1416-23. PMID: 15546210, DOI: 10.1021/bc0498267.
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.Chen MK, Baidoo K, Verina T, Guilarte TR. Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization. Brain : A Journal Of Neurology 2004, 127: 1379-92. PMID: 15069023, DOI: 10.1093/brain/awh161.

Clinical Trials

Conditions	Study Title
Mental Health & Behavioral Research	M1 Schizophrenia PET Study
Diseases of the Nervous System	Meditation and Synaptic Density
Diseases of the Nervous System	Study of Safety and of the Mechanism of BLZ945 in ALS Patients
Alzheimer's Disease	AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid
Alzheimer's Disease	A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
Men's Health; Women's Health	Evaluating the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923
Mental Health & Behavioral Research	HPA axis function in the brains of PTSD, Trauma Exposed, or Otherwise Healthy research participants utilizing PET and MRI imaging
Diseases of the Endocrine System; Genetics - Adult	A Phase I/II Study of VTX-801 in Adult Patients With Wilson's Disease (GATEWAY)
Mental Health & Behavioral Research	Eligibility for Participation in Neuroimaging Studies
Diseases of the Lung; Diseases of the Respiratory Systems	Safety, Tolerability, Kinetics, and Repeatability of the Novel LPA1 PET Ligand 18F-BMS-986327
Child Development & Autism	PET Imaging Study for Young Adults with ASD
Diseases of the Nervous System	Imaging the Dopamine Transporter in Parkinson's Disease
Addictive Behaviors; Mental Health & Behavioral Research; Tobacco Addiction	Imaging smoking-induced dopamine release utilizing PET imaging and nicotine patches
Diseases of the Nervous System; Alzheimer's Disease	Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
Addictive Behaviors	Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo using 11C-UCB-J PET
Diseases of the Nervous System; Mental Health & Behavioral Research	Examination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral Research	Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD
Diseases of the Nervous System	Imaging pancreatic beta-cells with PET neuroimaging agent 11C-PHNO
Mental Health & Behavioral Research	Imaging mGluR5 and synaptic density in psychiatric disorders
Mental Health & Behavioral Research	Imaging SV2A in mood disorders

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Ming-Kai Chen, MD, PhD

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