Graeme Mason, PhD
Biography
Research & Publications
News
Appointments
Biography
Dr. Grame F. Mason develops experimental models and methods for studies of brain metabolism using 1H and 13C Nuclear Magnetic Resonance (NMR) and Mass Spectrometry in conjunction with 13C isotopic labeling in vivo, in cell preparations, and other systems. His work began during his graduate studies at Yale where he used a rat model for the experimental determination of brain glucose transport kinetics, energetics, and neurotransmitter metabolism. Dr. Mason received further training at the University of Alabama at Birmingham, where he guided the group's 13C-labeling studies of the human brain in vivo in the 4.1T whole-body MR system. Dr. Mason studies metabolism and neurotransmission in the brain in vivo, including effects of psychiatric disorders and substances such as alcohol and nicotine; Dr. Mason examines healthy subjects and patients to investigate relationships among GABA, glutamate, and glutamine concentrations and their rates of synthesis and release in the brain, in particular with regard to effects of acute and chronic use of alcohol. He also studies detailed kinetic modeling of isotopomer and isotopologues using data from high-resolution NMR and mass spectrometry.
Education & Training
- Postdoctoral FellowUniversity of Alabama at Birmingham, Center for Nuclear Imaging Research, Birmingham, AL (1994)
- Postdoctoral Research AssociateYale University, New Haven, CT (1993)
- PhDYale University (1991)
- Graduate StudyYale University, New Haven, CT (1991)
- Research AssistantHershey Medical Center, Hershey, PA (1986)
- BSThe Pennsylvania State University, Nuclear Engineering, Minor in Spanish (1986)
Activities
- Cerebral oxidation of ethanol is similar in rats and humans and rises with heavy alcohol consumptioOrlando, FL, United States 2022Annual Meeting of the Research Society on Alcoholism
- Non-Linear Estimation of Enzyme KineticsPocatello, ID, United States 2022James C.K. Lai Retirement Memorial Symposium
- Álcool e Metabolismo CerebralPorto Alegre, RS, Brazil 2022Série de Pós-Graduação em Neurociências
- Alcohol and Brain MetabolismLos Angeles, CA, United States 2022UCLA Brain Research Institute MRS Seminar
- Of Rats and People: Strategies for Compartmental Metabolic Analysis in the BrainDallas, TX, United States 2021Advanced Imaging Research Center Seminar Series
- Alcohol provides brain energy via oxidation of ethanol and hepatically derived acetate. Ketones can also meet those needsMinneapolis, MN, United States 2019Symposium Alcohol Metabolism and the role of Ketone Bodies to Alleviate Symptoms of Alcohol Withdrawal
- Alcohol metabolism and the brain: implications for addiction and withdrawalPalo Alto, CA, United States 2019Biosciences Division seminar
- 13C Labeling Studies and Challenges of Spectral and Kinetic FittingNew York, NY, United States 2018Second Annual INSPECTOR Workshop
- Metabolic Modeling of 13C Hyperpolarized Data for Studying Brain Metabolism and NeurotransmissionPhiladelphia, PA, United States 2018The Fifth International Workshop on Metabolic Imaging
- Efeitos Neuroquímicos do Álcool Observados in vivo com Ressonância MagnéticaJuiz de Fora, MG, Brazil 2018Efeitos Neuroquímicos do Álcool Observados in vivo com Ressonância Magnética
- Potential for Ketone Bodies to Support Sobriety from AlcoholCopenhagen, Denmark 2018Potential for Ketone Bodies to Support Sobriety from Alcohol
- A Metabolic Perspective of Alcohol Use and DependenceCopenhagen, Denmark 2018A Metabolic Perspective of Alcohol Use and Dependence
- Alcohol and Brain MetabolismWorcester, MA, United States 2017Alcohol and Brain Metabolism
- A metabolic perspective of alcohol dependence and withdrawalDelhi, DL, India 2017A metabolic perspective of alcohol dependence and withdrawal
- Effects of alcohol and nicotine on brain metabolismBoston, MA, United States 2017Neuroscience Seminar
- The first steps to getting your own moneyBerlin, Berlin, Germany 2017The first steps to getting your own money
- Grantcraft: The art of writing a successful grant proposalBerlin, Berlin, Germany 2017Grantcraft: The art of writing a successful grant proposal
- Basic NMR TheoryDelhi, DL, India 2017Basic NMR Theory
- 13C Studies of Metabolism In Vivo: Nuclear Magnetic Resonance (NMR) Spectroscopy and Mathematical ModelingDelhi, DL, India 201713C Studies of Metabolism In Vivo: Nuclear Magnetic Resonance (NMR) Spectroscopy and Mathematical Modeling
- Alcohol-Related Disorders: A Metabolic PerspectiveNew York, NY, United States 2016Grand Rounds
- Practical Aspects of 13C MR StudiesKonstanz, BW, Germany 2016MR Spectroscopy: From Current Best Practice to Latest Frontiers
- Relationships of Glutamate Concentrations with Glutamatergic FiringAtlanta, GA, United States 2016Modulation of Glutamate in Task Active States in Humans: Applications to Psychiatry with Real-time Functional MRS
- Principles of Metabolic Modeling of Isotopic LabelingPhiladelphia, PA, United States 2016Principles of Metabolic Modeling ofThe Fourth International Workshop on Hyperpolarized Carbon-13 and Its Applications in Metabolic Imaging
- Magnetic Resonance Spectroscopy of Brain Metabolism of Glucose, Acetate, and EthanolAthens, GA, United States 2015Distinguished Lecture for Neurosience and Imaging
- 13C MRS Studies of Brain Metabolism of Alcohol and AcetateBirmingham, AL, United States 2015Lecture for Visual Brain Core Seminar Series
- Brain Oxidation of Ethanol and Acetate: Influence of Chronic Alcohol ExposureIndianapolis, IN, United States 2015Brain Oxidation of Ethanol and Acetate: Influence of Chronic Alcohol Exposure
- Alcohol and Brain MetabolismCharleston, SC, United States 2014Addiction Science Seminar
- Measurement of Heterogeneous Metabolism by 13C Magnetic Resonance Spectroscopy: Practicalities and StrategiesLexington, KY, United States 2014Stable Isotope Resolved Metabolomics Symposium
- Metabolic Kinetics in Psychiatric DiseaseLisbon, Portugal 2013Dynamic Spectroscopy of the Brain with Alcohol and Nicotine
- MR Spectroscopy and Imaging for Beginners – parts 1 and 2Lisbon, Portugal 2013Dynamic Imaging and Spectroscopy of Psychiatric Illness
- Alcohol and the Brain: a Metabolic PerspectiveOrlando, Florida, United States 2013Alcohol and Calories in Alcohol Use and Related Disorders
- Ethanol, its Metabolism, and the BrainBoston, Massachusetts, United States 2013Neuroscience Seminar
- Espectroscopia por ressonância magnética: teoria e aplicação ao estudo dos efeitos cerebrais de étanol em dose agudaRio de Janeiro, RJ, Brazil 2011Congresso Brasileiro de Psiquiatria
- Efeitos agudos de étanol no cérebro investigados pela técnica de espectroscopia de ressonância nuclearPorto Alegre, RS, Brazil 2011Efeitos agudos de étanol no cérebro investigados pela técnica de espectroscopia de ressonância nuclear
- Compartmental analysis and sensitivities of kinetic carbon-13 labeling studiesAthens, Attica, Greece 2011International Society of Neurochemistry
- Efeitos neuroquímicos do álcool e da nicotina observados in vivo com ressonância magnéticaJuiz de Fora, MG, Brazil 2011Instituto de Ciências Humanas
- Magnetic Resonance Spectroscopy and Neurotransmitters in Psychiatric DisordersLanzhou, Gansu, China 2009Magnetic Resonance Spectroscopy and Neurotransmitters in Psychiatric Disorders
- Neurochemical Effects of Acute Nicotine and AlcoholLanzhou, Gansu, China 2009Neurochemical Effects of Acute Nicotine and Alcohol
- Magnetic Resonance Spectroscopy Applied to Study NeurochemistryLanzhou, Gansu, China 2009Magnetic Resonance Spectroscopy Applied to Study Neurochemistry
- MRS Methodology for Studies of AlcoholismParis, IDF, France 2008Joint INSERM-NIAAA Meeting
- Dynamic Measurements of Cortical GABAKyoto, Kyoto Prefecture, Japan 2004International Society of Magnetic Resonance in Medicine
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Editor's Recognition for Reviewing, Biological Psychiatry | 2020 | |
Inducted into the Academy Distinguished Investigator Council | Academy for Radiology & Biomedical Imaging Research | 2018 |
Editor's Recognition for Reviewing, Biological Psychiatry | 2016 | |
Elected Fellow | American College of Neuropsychopharmacology | 2015 |
Editor's Recognition for Reviewing, Biological Psychiatry | 2015 | |
Elected Senior Fellow | International Society of Magnetic Resonance in Medicine | 2015 |
Editor's Recognition for Reviewing, Biological Psychiatry | 2014 | |
Editor's Recognition for Reviewing | Biological Psychiatry | 2012 |
Editor's Recognition for Reviewing | Biological Psychiatry | 2011 |
Editor's Recognition for Reviewing | Biological Psychiatry | 2009 |
Editor’s Recognition Award for Reviewing with Special Distinction | Radiology | 2003, 2004 |
NARSAD Young Investigator Award | NARSAD | 2002, 2004 |
Memorial Travel Award | American College of Neuropsychopharmacology | 2002 |
NARSAD Young Investigator Award | NARSAD | 2000, 2002 |
Honorable Mention – alternate for Memorial Travel Award for American College of Neuropsychopharmacology | American College of Neuropsychopharmacology | 2000 |
Stanley Foundation Young Investigator Award | Stanley Foundation | 1998, 2000 |
Student Travel Awards | Society of Magnetic Resonance in Medicine | 1991, 1992 |
NIH Graduate Fellowship | National Institutes of Health | 1986, 1991 |
National Science Foundation Fellowship Honorable Mention | National Science Foundation | 1986 |
Institute of Nuclear Power Operations (INPO) Scholarship | Institute of Nuclear Power Operations | 1984, 1986 |
John White Scholarship for Excellence in Spanish | 1984, 1986 |
Professional Service
Organization | Role | Date |
---|---|---|
Yale Conference for Alcohol Research and Education (Y-CARE) | Conference to bring together researchers from various areas of clinical practice and research at Yale and in the local community. | 2022 |
Research Society on Alcoholism, Education Committee Past Chair | Chairperson | 2020 - 2022 |
Research Society on Alcoholism, Developer of Online RSA Lecture Series | Recorded, edited, captioned series of lectures on alcohol-related topics by leaders in the field | 2019 - Present |
Neuroscience & Behavior Review Commitee (AA-4) | Member | 2019 - Present |
Journal of Neuropsychopharmacology | Journal Editorial Board | 2018 - Present |
Research Society on Alcoholism, Education Committee Chair | Chairperson | 2018 - 2020 |
Drug Abuse and Brain Imaging Training Program (DABITP), McLean Hospital, Boston, MA | Scientific Advisory Board | 2017 - Present |
Drug Abuse and Brain Imaging Training Program, McLean Hospital | Member | 2017 - Present |
Research Society on Alcoholism, Education Committee Vice-Chair | Vice Chair | 2017 - 2018 |
American College of Neuropsychopharmacology Education Committee | Committee Member | 2016 - Present |
American College of Neuropsychopharmacology, Education Committee | 2016 - Present | |
Alcohol: Clinical & Experimental Research | Field Editor | 2016 - Present |
Member, NPAS Study Section | Grant reviewer | 2015 - 2016 |
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | Journal Editorial Board | 2015 - Present |
Alcohol Alcohol Center, Medical University of South Carolina | Scientific Advisory Board | 2014 - 2019 |
Research Society on Alcoholism Education Committee | Chair, Gordis Award Subcommittee | 2014 - 2018 |
Psychiatric MR Study Group, in the International Society of Magnetic Resonance in Medicine (ISMRM) | Chairperson | 2012 - 2015 |
Research Society on Alcoholism, Education Committee Member | Committee Member | 2011 - 2022 |
Society of Biological Psychiatry | Program Committee | 2011 - Present |
Research Society on Alcoholism | Education Committee | 2011 - Present |
Research Society on Alcoholism | Research Priorities Committee | 2008 - 2009 |
International Society of Magnetic Resonance in Medicine | Ad-Hoc Presidential Appointee to Study Group Review Committee | 2007 - 2008 |
Research Society on Alcoholism | Program Committee | 2006 - 2008 |
Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS) Association of America | Scientific Advisory Board | 2005 - 2009 |
International Society of Magnetic Resonance in Medicine (ISMRM) | Past Chair of Psychiatric MR Study Group | 2005 - 2006 |
Magnetic Resonance Research Center | Protocol Review Committee | 2005 - Present |
Yale Human Investigation Committee | Advising on imaging-related protocols | 2004 - Present |
National Institute of Complementary and Alternative Medicine (NCCAM) | Grant reviewer | 2003 - 2009 |
National Institutes of Health | Grant reviewer | 2003 - Present |
International Society of Magnetic Resonance in Medicine | Member of the Study Group Review Committee | 2003 - 2005 |
International Society of Magnetic Resonance in Medicine (ISMRM) | Psychiatric MR Study Group | 2003 - 2005 |
Biological Psychiatry | Journal Editorial Board | 2002 - Present |
International Society of Magnetic Resonance in Medicine (ISMRM) | Conceived and organized Psychiatric Magnetic Resonance Study Group | 2001 - 2003 |
Yale Human Investigation Committee | Protocol reviewer | 2000 - 2004 |
Departments & Organizations
- Bioimaging Sciences
- Center for Biomedical Data Science
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Center for the Translational Neuroscience of Alcohol
- Diabetes Research Center
- Magnetic Resonance Research Center
- Magnetic Resonance Spectroscopy
- Neurocognition, Neurocomputation, and Neurogenetics, Division of
- Neuroimaging Sciences Training Program
- Neuroscience Research Training Program (NRTP)
- Psychiatry
- Radiology & Biomedical Imaging
- Radiology Diversity Program
- Yale Ventures