Publications

Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling.

Authors: Balodis, I.M., Kober, H., Worhunsky, P.D., Stevens, M.C., Pearlson, G.D. & Potenza, M.N.

Journal: Biological Psychiatry (2012)

Abstract:

BACKGROUND:

Mesocorticolimbic neurocircuitry and impulsivity have both been implicated in pathological gambling (PG) and in reward processing. However, the neural underpinnings of specific phases of reward and loss processing in PG and their relationships to impulsivity remain only partially understood. The present functional magnetic resonance imaging study examined brain activity associated with different phases of reward and loss processing in PG. Given an inverse relationship between ventral striatal recruitment during anticipation of monetary rewards and impulsivity in alcohol dependence, the current study explored whether a similar association might also be present in PG.

METHODS:

Fourteen adults with PG and 14 control comparison participants performed the Monetary Incentive Delay Task to identify brain activation changes associated with reward/loss prospect, reward/loss anticipation, and reward/loss notification. Impulsivity was assessed separately using the Barratt Impulsiveness Scale.

RESULTS:

Relative to the control comparison group, the PG group exhibited significantly reduced activity in the ventromedial prefrontal cortex, insula, and ventral striatum during several phases, including the prospect and anticipation phases of both gains and losses. Activity in the ventral striatum correlated inversely with levels of impulsivity in PG participants, consistent with prior findings in alcohol dependence.

CONCLUSIONS:

Relatively decreased activity in corticostriatal neurocircuitry during multiple phases of reward processing suggests consistent alterations in neurocircuitry underlying incentive valuation and loss prediction. Together with findings in alcohol dependence, these results suggest that impulsive tendencies in addictions may be reflected in diminished ventral striatal activations to reward anticipation and may represent targets for treatment development in addictions.

Hazardous Drinking and Dimensions of Impulsivity, Behavioral Approach, and Inhibition in Adult Men and Women.

Authors: Hamilton, K.R., Sinha, R. & Potenza, M.N.

Journal: Alcoholism, clinical and experimental research (2012)

Abstract:

INTRODUCTION:

Hazardous drinking is characterized by decisions to engage in excessive or risky patterns of alcohol consumption. Levels of impulsivity and behavioral approach and inhibition may differ in hazardous drinkers and nonhazardous drinkers. A comparison of the relative levels of dimensions of impulsivity and behavioral inhibition and approach in adult men and women hazardous and nonhazardous drinkers may inform treatment and prevention efforts.

METHODS:

In the present research, 466 men and women from a community sample were administered the Alcohol Use Disorders Identification Test (AUDIT), the Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scale, and the Barratt Impulsiveness Scale, version 11 (BIS-11). Relations among the dimensions of these constructs were examined using multivariate analysis of covariance (MANCOVA), with age and race as covariates.

RESULTS:

There were main effects of hazardous drinking on all 3 dimensions of impulsivity, the behavioral inhibition system, and the behavioral activation system Reward Responsiveness, and Fun-Seeking components, with hazardous drinkers scoring higher than nonhazardous drinkers.

CONCLUSIONS:

This research provides a better understanding of the manner in which impulsivity and behavioral inhibition and approach tendencies relate to hazardous alcohol use in men and women. The present results have implications for alcohol-related prevention and treatment strategies for adult men and women.

Other Publications

1990-2000

Graminski, G.F., Jayawickreme, C.K., Potenza, M.N. & Lerner, M.R.

Pigment dispersion in frog melanophores can be induced by a phorbol ester or stimulation of a recombinant receptor that activates phospholipase C. The Journal of biological chemistry268, 5957-5964 (1993).

Lerner, M.R., Potenza, M.N., Graminski, G.F., McClintock, T., Jayawickreme, C.K. & Karne, S.

A new tool for investigating G protein-coupled receptors. Ciba Foundation symposium179, 76-84; discussion 84-77 (1993).

McClintock, T.S., Graminski, G.F., Potenza, M.N., Jayawickreme, C.K., Roby-Shemkovitz, A. & Lerner, M.R.

Functional expression of recombinant G-protein-coupled receptors monitored by video imaging of pigment movement in melanophores. Analytical biochemistry209, 298-305 (1993).

Potenza, M., Bowser, R., Muller, H. & Novick, P.

SEC6 encodes an 85 kDa soluble protein required for exocytosis in yeast. Yeast8, 549-558 (1992).

Potenza, M.N. & Lerner, M.R.

A rapid quantitative bioassay for evaluating the effects of ligands upon receptors that modulate cAMP levels in a melanophore cell line. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society5, 372-378 (1992).

Potenza, M.N. & Lerner, M.R.

A recombinant vaccinia virus infects Xenopus melanophores. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society4, 186-192 (1991).

Potenza, M.N. & Lerner, M.R.

Characterization of a serotonin receptor endogenous to frog melanophores. Naunyn-Schmiedeberg's archives of pharmacology349, 11-19 (1994).

Potenza, M.N., Gold, S.J., Roby-Shemkowitz, A., Lerner, M.R. & Nestler, E.J.

Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay. The Journal of pharmacology and experimental therapeutics291, 482-491 (1999).

Potenza, M.N., Graminski, G.F. & Lerner, M.R.

A method for evaluating the effects of ligands upon Gs protein-coupled receptors using a recombinant melanophore-based bioassay. Analytical biochemistry206, 315-322 (1992).

Potenza, M.N., Graminski, G.F., Schmauss, C. & Lerner, M.R.

Functional expression and characterization of human D2 and D3 dopamine receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience14, 1463-1476 (1994).

Potenza, M.N., Holmes, J.P., Kanes, S.J. & McDougle, C.J.

Olanzapine treatment of children, adolescents, and adults with pervasive developmental disorders: an open-label pilot study. Journal of clinical psychopharmacology19, 37-44 (1999).

Potenza, M.N., Steinberg, M.A., McLaughlin, S.D., Rounsaville, B.J. & O'Malley, S.S.

Illegal behaviors in problem gambling: analysis of data from a gambling helpline. The journal of the American Academy of Psychiatry and the Law28, 389-403 (2000).

Rahman, Z., Gold, S.J., Potenza, M.N., Cowan, C.W., Ni, Y.G., He, W., Wensel, T.G. & Nestler, E.J.

Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. The Journal of neuroscience : the official journal of the Society for Neuroscience19, 2016-2026 (1999).

Weiss, E.L., Potenza, M.N., McDougle, C.J. & Epperson, C.N.

Olanzapine addition in obsessive-compulsive disorder refractory to selective serotonin reuptake inhibitors: an open-label case series. The Journal of clinical psychiatry60, 524-527 (1999).

2001-2005

Chambers, R.A. & Potenza, M.N.

Neurodevelopment, impulsivity, and adolescent gambling. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming19, 53-84 (2003).

Chambers, R.A., Potenza, M.N., Hoffman, R.E. & Miranker, W.

Simulated apoptosis/neurogenesis regulates learning and memory capabilities of adaptive neural networks. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology29, 747-758 (2004).

Chambers, R.A., Taylor, J.R. & Potenza, M.N.

Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. The American journal of psychiatry160, 1041-1052 (2003).

Desai, R.A., Maciejewski, P.K., Dausey, D.J., Caldarone, B.J. & Potenza, M.N.

Health correlates of recreational gambling in older adults. The American journal of psychiatry161, 1672-1679 (2004).

Desai, R.A., Maciejewski, P.K., Pantalon, M.V. & Potenza, M.N.

Gender differences in adolescent gambling. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists17, 249-258 (2005).

Grant, J.E., Kim, S.W., Potenza, M.N., Blanco, C., Ibanez, A., Stevens, L., Hektner, J.M. & Zaninelli, R.

Paroxetine treatment of pathological gambling: a multi-centre randomized controlled trial. International clinical psychopharmacology18, 243-249 (2003).

Ledgerwood, D.M., Steinberg, M.A., Wu, R. & Potenza, M.N.

Self-reported gambling-related suicidality among gambling helpline callers. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors19, 175-183 (2005).

Lynch, W.J., Maciejewski, P.K. & Potenza, M.N.

Psychiatric correlates of gambling in adolescents and young adults grouped by age at gambling onset. Archives of general psychiatry61, 1116-1122 (2004).

Potenza, M.N. & Winters, K.C.

The neurobiology of pathological gambling: translating research findings into clinical advances. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming19, 7-10 (2003).

Potenza, M.N.

Advancing treatment strategies for pathological gambling. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming21, 91-100 (2005).

Potenza, M.N.

The neurobiology of pathological gambling. Seminars in clinical neuropsychiatry6, 217-226 (2001).

Potenza, M.N., Brodkin, E.S., Joe, B., Luo, X., Remmers, E.F., Wilder, R.L., Nestler, E.J. & Gelernter, J.

Genomic regions controlling corticosterone levels in rats. Biological psychiatry55, 634-641 (2004).

Potenza, M.N., Fiellin, D.A., Heninger, G.R., Rounsaville, B.J. & Mazure, C.M.

Gambling: an addictive behavior with health and primary care implications. Journal of general internal medicine17, 721-732 (2002).

Potenza, M.N., Kosten, T.R. & Rounsaville, B.J.

Pathological gambling. JAMA : the journal of the American Medical Association286, 141-144 (2001).

Potenza, M.N., Leung, H.C., Blumberg, H.P., Peterson, B.S., Fulbright, R.K., Lacadie, C.M., Skudlarski, P. & Gore, J.C.

An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers. The American journal of psychiatry160, 1990-1994 (2003).

Potenza, M.N., Steinberg, M.A. & Wu, R.

Characteristics of gambling helpline callers with self-reported gambling and alcohol use problems. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming21, 233-254 (2005).

Potenza, M.N., Steinberg, M.A., McLaughlin, S.D., Wu, R., Rounsaville, B.J. & O'Malley, S.S.

Gender-related differences in the characteristics of problem gamblers using a gambling helpline. The American journal of psychiatry158, 1500-1505 (2001).

Potenza, M.N., Steinberg, M.A., McLaughlin, S.D., Wu, R., Rounsaville, B.J., Krishnan-Sarin, S., George, T.P. & O'Malley, S.S.

Characteristics of tobacco-smoking problem gamblers calling a gambling helpline. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions13, 471-493 (2004).

Potenza, M.N., Steinberg, M.A., Skudlarski, P., Fulbright, R.K., Lacadie, C.M., Wilber, M.K., Rounsaville, B.J., Gore, J.C. & Wexler, B.E.

Gambling urges in pathological gambling: a functional magnetic resonance imaging study. Archives of general psychiatry60, 828-836 (2003).

Potenza, M.N., Xian, H., Shah, K., Scherrer, J.F. & Eisen, S.A.

Shared genetic contributions to pathological gambling and major depression in men. Archives of general psychiatry62, 1015-1021 (2005).

Tucker, K.A., Potenza, M.N., Beauvais, J.E., Browndyke, J.N., Gottschalk, P.C. & Kosten, T.R.

Perfusion abnormalities and decision making in cocaine dependence. Biological psychiatry56, 527-530 (2004).

2006

Desai, R.A., Maciejewski, P.K., Pantalon, M.V. & Potenza, M.N.

Gender differences among recreational gamblers: association with the frequency of alcohol use. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors20, 145-153 (2006).

Grant, J.E. & Potenza, M.N.

Escitalopram treatment of pathological gambling with co-occurring anxiety: an open-label pilot study with double-blind discontinuation. International clinical psychopharmacology21, 203-209 (2006).

Grant, J.E., Potenza, M.N., Hollander, E., Cunningham-Williams, R., Nurminen, T., Smits, G. & Kallio, A.

Multicenter investigation of the opioid antagonist nalmefene in the treatment of pathological gambling. The American journal of psychiatry163, 303-312 (2006).

Kosten, T.R., Scanley, B.E., Tucker, K.A., Oliveto, A., Prince, C., Sinha, R., Potenza, M.N., Skudlarski, P. & Wexler, B.E.

Cue-induced brain activity changes and relapse in cocaine-dependent patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology31, 644-650 (2006).

Potenza, M.N.

Should addictive disorders include non-substance-related conditions? Addiction101 Suppl 1, 142-151 (2006).

Potenza, M.N., Maciejewski, P.K. & Mazure, C.M.

A gender-based examination of past-year recreational gamblers. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming22, 41-64 (2006).

Potenza, M.N., Steinberg, M.A., Wu, R., Rounsaville, B.J. & O'Malley S, S.

Characteristics of Older Adult Problem Gamblers Calling a Gambling Helpline. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming (2006).

2007

Barry, D.T., Maciejewski, P.K., Desai, R.A. & Potenza, M.N.

Income differences and recreational gambling. Journal of addiction medicine1, 145-153 (2007).

Cronce, J.M., Corbin, W.R., Steinberg, M.A. & Potenza, M.N.

Self-perception of gambling problems among adolescents identified as at-risk or problem gamblers. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming23, 363-375 (2007).

Desai, R.A., Desai, M.M. & Potenza, M.N.

Gambling, health and age: data from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors21, 431-440 (2007).

Krishnan-Sarin, S., Reynolds, B., Duhig, A.M., Smith, A., Liss, T., McFetridge, A., Cavallo, D.A., Carroll, K.M. & Potenza, M.N.

Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug and alcohol dependence88, 79-82 (2007).

Liu, T. & Potenza, M.N.

Problematic Internet use: clinical implications. CNS spectrums12, 453-466 (2007).

Potenza, M.N., Voon, V. & Weintraub, D.

Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease. Nature clinical practice. Neurology3, 664-672 (2007).

2008

Barry, D.T., Steinberg, M.A., Wu, R. & Potenza, M.N.

Characteristics of black and white callers to a gambling helpline. Psychiatr Serv59, 1347-1350 (2008).

Brewer, J.A. & Potenza, M.N.

The neurobiology and genetics of impulse control disorders: relationships to drug addictions. Biochemical pharmacology75, 63-75 (2008).

Brewer, J.A., Worhunsky, P.D., Carroll, K.M., Rounsaville, B.J. & Potenza, M.N.

Pretreatment brain activation during stroop task is associated with outcomes in cocaine-dependent patients. Biological psychiatry64, 998-1004 (2008).

Desai, R.A. & Potenza, M.N.

Gender differences in the associations between past-year gambling problems and psychiatric disorders. Social psychiatry and psychiatric epidemiology43, 173-183 (2008).

Grant, J.E., Kim, S.W., Hollander, E. & Potenza, M.N.

Predicting response to opiate antagonists and placebo in the treatment of pathological gambling. Psychopharmacology200, 521-527 (2008).

Grant, J.E., Kim, S.W., Odlaug, B.L. & Potenza, M.N.

Daily Tobacco Smoking in Treatment-Seeking Pathological Gamblers: Clinical Correlates and Co-occurring Psychiatric Disorders. Journal of addiction medicine2, 178-184 (2008).

Pantalon, M.V., Maciejewski, P.K., Desai, R.A. & Potenza, M.N.

Excitement-seeking gambling in a nationally representative sample of recreational gamblers. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming24, 63-78 (2008).

Potenza, M.N.

Review. The neurobiology of pathological gambling and drug addiction: an overview and new findings. Philosophical transactions of the Royal Society of London. Series B, Biological sciences363, 3181-3189 (2008).

Potenza, M.N., Brodkin, E.S., Yang, B.Z., Birnbaum, S.G., Nestler, E.J. & Gelernter, J.

Quantitative trait locus analysis identifies rat genomic regions related to amphetamine-induced locomotion and Galpha(i3) levels in nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology33, 2735-2746 (2008).

Schepis, T.S., Desai, R.A., Smith, A.E., Cavallo, D.A., Liss, T.B., McFetridge, A., Potenza, M.N. & Krishnan-Sarin, S.

Impulsive sensation seeking, parental history of alcohol problems, and current alcohol and tobacco use in adolescents. Journal of addiction medicine2, 185-193 (2008).

Williams, W.A. & Potenza, M.N.

[The neurobiology of impulse control disorders]. Rev Bras Psiquiatr30 Suppl 1, S24-30 (2008).

Xian, H., Shah, K.R., Potenza, M.N., Volberg, R., Chantarujikapong, S., True, W.R., Lyons, M.J., Tsuang, M.T. & Eisen, S.A.

A Latent Class Analysis of DSM-III-R Pathological Gambling Criteria in Middle-Aged Men: Association with Psychiatric Disorders. Journal of addiction medicine2, 85-95 (2008).

2009

Balodis, I.M., Potenza, M.N. & Olmstead, M.C.

Binge drinking in undergraduates: relationships with sex, drinking behaviors, impulsivity, and the perceived effects of alcohol. Behavioural pharmacology20, 518-526 (2009).

Barry, D.T., Steinberg, M.A., Wu, R. & Potenza, M.N.

Differences in characteristics of Asian American and white problem gamblers calling a gambling helpline. CNS spectrums14, 83-91 (2009).

Blanco, C., Potenza, M.N., Kim, S.W., Ibanez, A., Zaninelli, R., Saiz-Ruiz, J. & Grant, J.E.

A pilot study of impulsivity and compulsivity in pathological gambling. Psychiatry research167, 161-168 (2009).

Brewer, J.A., Sinha, R., Chen, J.A., Michalsen, R.N., Babuscio, T.A., Nich, C., Grier, A., Bergquist, K.L., Reis, D.L., Potenza, M.N., Carroll, K.M. & Rounsaville, B.J.

Mindfulness training and stress reactivity in substance abuse: results from a randomized, controlled stage I pilot study. Substance abuse : official publication of the Association for Medical Education and Research in Substance Abuse30, 306-317 (2009).

Desai, R.A. & Potenza, M.N.

A cross-sectional study of problem and pathological gambling in patients with schizophrenia/schizoaffective disorder. The Journal of clinical psychiatry70, 1250-1257 (2009).

Desai, R.A., Manley, M., Desai, M.M. & Potenza, M.N.

Gender differences in the association between body mass index and psychopathology. CNS spectrums14, 372-383 (2009).

Kim, S.W., Grant, J.E., Potenza, M.N., Blanco, C. & Hollander, E.

The Gambling Symptom Assessment Scale (G-SAS): a reliability and validity study. Psychiatry research166, 76-84 (2009).

Leeman, R.F., Grant, J.E. & Potenza, M.N.

Behavioral and neurological foundations for the moral and legal implications of intoxication, addictive behaviors and disinhibition. Behavioral sciences & the law27, 237-259 (2009).

Liu, T., Maciejewski, P.K. & Potenza, M.N.

The relationship between recreational gambling and substance abuse/dependence: data from a nationally representative sample. Drug and alcohol dependence100, 164-168 (2009).

Potenza, M.N. & Taylor, J.R.

Found in translation: understanding impulsivity and related constructs through integrative preclinical and clinical research. Biological psychiatry66, 714-716 (2009).

Potenza, M.N.

Non-substance and substance addictions. Addiction104, 1016-1017 (2009).

Potenza, M.N.

The importance of animal models of decision making, gambling, and related behaviors: implications for translational research in addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology34, 2623-2624 (2009).

Potenza, M.N., Koran, L.M. & Pallanti, S.

The relationship between impulse-control disorders and obsessive-compulsive disorder: a current understanding and future research directions. Psychiatry research170, 22-31 (2009).

Topf, J.L., Yip, S.W. & Potenza, M.N.

Pathological Gambling: Biological and Clinical Considerations. Journal of addiction medicine3, 111-119 (2009).

Yip, S.W., Sacco, K.A., George, T.P. & Potenza, M.N.

Risk/reward decision-making in schizophrenia: a preliminary examination of the influence of tobacco smoking and relationship to Wisconsin Card Sorting Task performance. Schizophrenia research110, 156-164 (2009).

2010

Brewer, J.A., Bowen, S., Smith, J.T., Marlatt, G.A. & Potenza, M.N.

Mindfulness-based treatments for co-occurring depression and substance use disorders: what can we learn from the brain? Addiction105, 1698-1706 (2010).

Brewer, J.A., Potenza, M.N. & Desai, R.A.

Differential associations between problem and pathological gambling and psychiatric disorders in individuals with and without alcohol abuse or dependence. CNS spectrums15, 33-44 (2010).

Cavallo, D.A., Smith, A.E., Schepis, T.S., Desai, R., Potenza, M.N. & Krishnan-Sarin, S.

Smoking expectancies, weight concerns, and dietary behaviors in adolescence. Pediatrics126, e66-72 (2010).

Desai, R.A., Krishnan-Sarin, S., Cavallo, D. & Potenza, M.N.

Video-gaming among high school students: health correlates, gender differences, and problematic gaming. Pediatrics126, e1414-1424 (2010).

Grant, J.E., Chamberlain, S.R., Odlaug, B.L., Potenza, M.N. & Kim, S.W.

Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study. Psychopharmacology212, 603-612 (2010).

Morgan, P.T., Desai, R.A. & Potenza, M.N.

Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related Conditions. Alcoholism, clinical and experimental research34, 1759-1767 (2010).

Potenza, M.N. & de Wit, H.

Control yourself: alcohol and impulsivity. Alcoholism, clinical and experimental research34, 1303-1305 (2010).

Potenza, M.N.

What integrated interdisciplinary and translational research may tell us about addiction. Addiction105, 792-793; discussion 795-796 (2010).

Rutherford, H.J., Mayes, L.C. & Potenza, M.N.

Neurobiology of adolescent substance use disorders: implications for prevention and treatment. Child and adolescent psychiatric clinics of North America19, 479-492 (2010).

Vanbuskirk, K.A. & Potenza, M.N.

The Treatment of Obesity and Its Co-occurrence with Substance Use Disorders. Journal of addiction medicine4, 1-10 (2010).

Wareham, J.D. & Potenza, M.N.

Pathological gambling and substance use disorders. The American journal of drug and alcohol abuse36, 242-247 (2010).

Weinberger, A.H., Reutenauer, E.L., Jatlow, P.I., O'Malley, S.S., Potenza, M.N. & George, T.P.

A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers. Drug and alcohol dependence107, 188-195 (2010).

White, M.A., Grilo, C.M., O'Malley, S.S. & Potenza, M.N.

Clinical Case Discussion: Binge Eating Disorder, Obesity and Tobacco Smoking. Journal of addiction medicine4, 11-19 (2010).

Xu, J., DeVito, E.E., Worhunsky, P.D., Carroll, K.M., Rounsaville, B.J. & Potenza, M.N.

White matter integrity is associated with treatment outcome measures in cocaine dependence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology35, 1541-1549 (2010).

2011

Balodis, I.M., Lacadie, C.M. & Potenza, M.N.

A Preliminary Study of the Neural Correlates of the Intensities of Self-Reported Gambling Urges and Emotions in Men with Pathological Gambling. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming (2011).

Barry, D.T., Stefanovics, E.A., Desai, R.A. & Potenza, M.N.

Differences in the associations between gambling problem severity and psychiatric disorders among black and white adults: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions20, 69-77 (2011).

Barry, D.T., Stefanovics, E.A., Desai, R.A. & Potenza, M.N.

Gambling problem severity and psychiatric disorders among Hispanic and white adults: findings from a nationally representative sample. Journal of psychiatric research45, 404-411 (2011).

Berlin, H.A., Braun, A., Simeon, D., Koran, L.M., Potenza, M.N., McElroy, S.L., Fong, T., Pallanti, S. & Hollander, E.

A double-blind, placebo-controlled trial of topiramate for pathological gambling. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2011).

Carroll, K.M., Kiluk, B.D., Nich, C., Babuscio, T.A., Brewer, J.A., Potenza, M.N., Ball, S.A., Martino, S., Rounsaville, B.J. & Lejuez, C.W.

Cognitive function and treatment response in a randomized clinical trial of computer-based training in cognitive-behavioral therapy. Substance use & misuse46, 23-34 (2011).

Franco, C.A., Maciejewski, P.K. & Potenza, M.N.

Past-year recreational gambling in a nationally representative sample: correlates of casino, non-casino, and both casino/non-casino gambling. Psychiatry research188, 269-275 (2011).

Gearhardt, A.N., Grilo, C.M., DiLeone, R.J., Brownell, K.D. & Potenza, M.N.

Can food be addictive? Public health and policy implications. Addiction106, 1208-1212 (2011).

Giddens, J.L., Xian, H., Scherrer, J.F., Eisen, S.A. & Potenza, M.N.

Shared genetic contributions to anxiety disorders and pathological gambling in a male population. Journal of affective disorders132, 406-412 (2011).

Jastreboff, A.M., Potenza, M.N., Lacadie, C., Hong, K.A., Sherwin, R.S. & Sinha, R.

Body mass index, metabolic factors, and striatal activation during stressful and neutral-relaxing states: an FMRI study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology36, 627-637 (2011).

Jia, Z., Worhunsky, P.D., Carroll, K.M., Rounsaville, B.J., Stevens, M.C., Pearlson, G.D. & Potenza, M.N.

An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence. Biological psychiatry70, 553-560 (2011).

Landi, N., Montoya, J., Kober, H., Rutherford, H.J., Mencl, W.E., Worhunsky, P.D., Potenza, M.N. & Mayes, L.C.

Maternal neural responses to infant cries and faces: relationships with substance use. Frontiers in psychiatry / Frontiers Research Foundation2, 32 (2011).

Leeman, R.F. & Potenza, M.N.

Impulse control disorders in Parkinson's disease: clinical characteristics and implications. Neuropsychiatry1, 133-147 (2011).

Liu, T.C., Desai, R.A., Krishnan-Sarin, S., Cavallo, D.A. & Potenza, M.N.

Problematic Internet use and health in adolescents: data from a high school survey in Connecticut. The Journal of clinical psychiatry72, 836-845 (2011).

Potenza, M.N., Sofuoglu, M., Carroll, K.M. & Rounsaville, B.J.

Neuroscience of behavioral and pharmacological treatments for addictions. Neuron69, 695-712 (2011).

Potenza, M.N., Walderhaug, E., Henry, S., Gallezot, J.D., Planeta-Wilson, B., Ropchan, J. & Neumeister, A.

Serotonin 1B receptor imaging in pathological gambling. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2011).

Potenza, M.N., Wareham, J.D., Steinberg, M.A., Rugle, L., Cavallo, D.A., Krishnan-Sarin, S. & Desai, R.A.

Correlates of at-risk/problem internet gambling in adolescents. Journal of the American Academy of Child and Adolescent Psychiatry50, 150-159 e153 (2011).

Schepis, T.S., Desai, R.A., Cavallo, D.A., Smith, A.E., McFetridge, A., Liss, T.B., Potenza, M.N. & Krishnan-Sarin, S.

Gender differences in adolescent marijuana use and associated psychosocial characteristics. Journal of addiction medicine5, 65-73 (2011).

Xu, J. & Potenza, M.N.

White matter integrity and five-factor personality measures in healthy adults. NeuroImage (2011).

Xu, J., Kober, H., Carroll, K.M., Rounsaville, B.J., Pearlson, G.D. & Potenza, M.N.

White matter integrity and behavioral activation in healthy subjects. Human brain mapping (2011).

Xu, J., Monterosso, J., Kober, H., Balodis, I.M. & Potenza, M.N.

Perceptual load-dependent neural correlates of distractor interference inhibition. PloS one6, e14552 (2011).

Yip, S.W., Lacadie, C., Xu, J., Worhunsky, P.D., Fulbright, R.K., Constable, R.T. & Potenza, M.N.

Reduced genual corpus callosal white matter integrity in pathological gambling and its relationship to alcohol abuse or dependence. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2011).

Yip, S.W., White, M.A., Grilo, C.M. & Potenza, M.N.

An exploratory study of clinical measures associated with subsyndromal pathological gambling in patients with binge eating disorder. Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming27, 257-270 (2011).

2012-Present

Xu, J. & Potenza, M.N. White matter integrity and five-factor personality measures in healthy adults. NeuroImage 59, 800-807 (2012).

Xu, J., Kober, H., Carroll, K.M., Rounsaville, B.J., Pearlson, G.D. & Potenza, M.N. White matter integrity and behavioral activation in healthy subjects. Human brain mapping 33, 994-1002 (2012).

Rahman, A.S., Pilver, C.E., Desai, R.A., Steinberg, M.A., Rugle, L., Krishnan-Sarin, S. & Potenza, M.N. The relationship between age of gambling onset and adolescent problematic gambling severity. Journal of psychiatric research (2012).

Potenza, M.N., Hong, K.I., Lacadie, C.M., Fulbright, R.K., Tuit, K.L. & Sinha, R. Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence. The American journal of psychiatry 169, 406-414 (2012).

Leeman, R.F. & Potenza, M.N. Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity. Psychopharmacology 219, 469-490 (2012).

Leeman, R.F., Patock-Peckham, J.A. & Potenza, M.N. Impaired control over alcohol use: An under-addressed risk factor for problem drinking in young adults? Exp Clin Psychopharmacol 20, 92-106 (2012).

Jamadar, S., Devito, E.E., Jiantonio, R.E., Meda, S.A., Stevens, M.C., Potenza, M.N., Krystal, J.H. & Pearlson, G.D. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology (2012).

Hamilton, K.R., Sinha, R. & Potenza, M.N. Hazardous Drinking and Dimensions of Impulsivity, Behavioral Approach, and Inhibition in Adult Men and Women. Alcoholism, clinical and experimental research (2012).

Hamilton, K.R. & Potenza, M.N. Relations among delay discounting, addictions, and money mismanagement: implications and future directions. The American journal of drug and alcohol abuse 38, 30-42 (2012).

Hamilton, K.R., Ansell, E.B., Reynolds, B., Potenza, M.N. & Sinha, R. Self-reported impulsivity, but not behavioral choice or response impulsivity, partially mediates the effect of stress on drinking behavior. Stress (2012).

Barry, D.T., Pilver, C., Potenza, M.N. & Desai, R.A. Prevalence and psychiatric correlates of pain interference among men and women in the general population. Journal of psychiatric research 46, 118-127 (2012).

Balodis, I.M., Kober, H., Worhunsky, P.D., Stevens, M.C., Pearlson, G.D. & Potenza, M.N. Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biological psychiatry 71, 749-757 (2012).

Amstadter, A.B., Daughters, S.B., Macpherson, L., Reynolds, E.K., Danielson, C.K., Wang, F., Potenza, M.N., Gelernter, J. & Lejuez, C.W. Genetic associations with performance on a behavioral measure of distress intolerance. Journal of psychiatric research 46, 87-94 (2012).