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Heping Zhang, PhD

Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive Sciences; Affiliated Faculty, Yale Institute for Global Health

Research & Publications
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Research Summary

Professor Zhang and members in his center conduct research in both the general area of regression and classification analyses and the methodologies for post-genome data analyses. In particular, with funding from multiple National Institutes of Health (NIH) grants, his group has been developing and implementing flexible and powerful approaches to the analyses of complex data including longitudinal data with multi- dimensional responses, neuroimaging data, genetic and genomic data. Zhang also has made major research efforts in: (a) child health ranging from the identification of neurological and genetic pathways in developing brain to the assessment of risk factors for pregnancy outcomes and to the understanding of cognitive and behavioral development in children; and (b) substance use, especially in understanding the transition from use to abuse. In addition, Dr. Zhang served as Principal Investigator of the data coordination and statistics center for the National Genomic and Proteomic Network for Preterm Birth Research and Reproductive Medicine Network.

Specialized Terms: Biostatistics; Genomics; Epidemiology; Psychiatry; Pregnancy; Infertility; Substance Use; Bioinformatics

Extensive Research Description

Analysis of Genomic Data for Complex Traits
Data Coordination Center for Reproductive Medicine
Clinical Trials for Infertility Treatments

Coauthors

Research Interests

Child Psychiatry; Epidemiology; Infertility; Mental Health; Pregnancy; Psychiatry; Computational Biology; Statistics; Genomics; Biostatistics

Public Health Interests

Clinical Trials; Epidemiology Methods; Genetics, Genomics, Epigenetics; Maternal & Child Health; Mental Health; Modeling; Reproduction; Child/Adolescent Health; COVID-19

Selected Publications

Use of random integration to test equality of high dimensional covariance matrices.Jiang Y, Wen C, Jiang Y, Wang X, Zhang H. Use of random integration to test equality of high dimensional covariance matrices. Statistica Sinica 2024, 33: 2359-2380. PMID: 37799490, PMCID: PMC10550010, DOI: 10.5705/ss.202020.0486.
Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesityVitek W, Sun F, Cardozo E, Hoeger K, Hansen K, Santoro N, Zhang H, Legro R. Moderate and increased physical activity is not detrimental to live birth rates among women with unexplained infertility and obesity. F&S Reports 2023, 4: 308-312. PMID: 37719091, PMCID: PMC10504528, DOI: 10.1016/j.xfre.2023.06.004.
Statistical Methodologies for Analyzing Genomic DataDuan F, Zhang H. Statistical Methodologies for Analyzing Genomic Data. 2023, 621-634. DOI: 10.1007/978-1-4471-7503-2_32.
Deep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK BiobankLiu Z, Dai W, Wang S, Yao Y, Zhang H. Deep learning identified genetic variants for COVID‐19‐related mortality among 28,097 affected cases in UK Biobank. Genetic Epidemiology 2023, 47: 215-230. PMID: 36691909, PMCID: PMC10006374, DOI: 10.1002/gepi.22515.
Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged WomenSiblini H, Al-Hendy A, Segars J, González F, Taylor H, Singh B, Flaminia A, Flores V, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. Nutrients 2023, 15: 320. PMID: 36678191, PMCID: PMC9861948, DOI: 10.3390/nu15020320.
Course of Tic Severity in Tourette Syndrome: The First Two DecadesLeckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. 2022, 80-85. DOI: 10.4324/9780203822937-8.
The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control methodTian T, Luo W, Tan J, Jiang Y, Chen M, Pan W, Yang S, Zhao J, Wang X, Zhang H. The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control method. Statistics And Its Interface 2021, 14: 3-12. DOI: 10.4310/20-sii634.
Rejoinder of “The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control method”Tian T, Luo W, Tan J, Jiang Y, Chen M, Pan W, Yang S, Zhao J, Wang X, Zhang H. Rejoinder of “The timing and effectiveness of implementing mild interventions of COVID-19 in large industrial regions via a synthetic control method”. Statistics And Its Interface 2021, 14: 33-36. DOI: 10.4310/20-sii654.
Super‐variants identification for brain connectivityLi T, Hu J, Wang S, Zhang H. Super‐variants identification for brain connectivity. Human Brain Mapping 2020, 42: 1304-1312. PMID: 33236465, PMCID: PMC7927294, DOI: 10.1002/hbm.25294.
Factors associated with study protocol adherence and bio banking participation in reproductive medicine clinical trials and their relationship to live birthEngmann L, Sun F, Legro RS, Diamond MP, Zhang H, Santoro N, Network R, Bartlebaugh C, Dodson W, Estes S, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Coutifaris C, Lecks K, Martino L, Marunich R, Snyder P, Alvero R, Comfort A, Crow M, Schlaff W, Casson P, Hohmann A, Mallette S, Christman G, Ohl D, Ringbloom M, Tang J, Bates G, Mason S, DiMaria N, Usadi R, Lucidi R, Rhea M, Baker V, Turner K, Trussell J, DelBasso D, Huang H, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Lamar C, DePaolo L, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Factors associated with study protocol adherence and bio banking participation in reproductive medicine clinical trials and their relationship to live birth. Human Reproduction 2020, 35: 2819-2831. PMID: 33190149, PMCID: PMC8453415, DOI: 10.1093/humrep/deaa232.
Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation inductionVitek W, Sun F, Hoeger KM, Santoro N, Diamond MP, Zhang H, Legro RS, Network E, Coutifaris C, Christman G, Robinson R, Brzyski R, Schlaff W, Casson P, Trussell J, Eisenberg E, Lamar C, DePaolo L. Short-term weight change and live birth among women with unexplained infertility and polycystic ovary syndrome undergoing ovulation induction. Fertility And Sterility 2020, 114: 1032-1039. PMID: 33036790, PMCID: PMC7953832, DOI: 10.1016/j.fertnstert.2020.06.002.
Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomesQuaas AM, Gavrizi SZ, Peck JD, Diamond MP, Legro RS, Robinson RD, Casson P, Christman GM, Zhang H, Hansen KR, Network E. Endometrial thickness after ovarian stimulation with gonadotropin, clomiphene, or letrozole for unexplained infertility, and association with treatment outcomes. Fertility And Sterility 2020, 115: 213-220. PMID: 32972733, PMCID: PMC7796980, DOI: 10.1016/j.fertnstert.2020.07.030.
Supervariants identification for breast cancerHu J, Li T, Wang S, Zhang H. Supervariants identification for breast cancer. Genetic Epidemiology 2020, 44: 934-947. PMID: 32808324, PMCID: PMC7924970, DOI: 10.1002/gepi.22350.
Depth Importance in Precision Medicine (DIPM): A Tree and Forest Based MethodChen V, Zhang H. Depth Importance in Precision Medicine (DIPM): A Tree and Forest Based Method. 2020, 243-259. DOI: 10.1007/978-3-030-46161-4_16.
Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trialHansen KR, Peck JD, Coward RM, Wild RA, Trussell JC, Krawetz SA, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H. Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial. Human Reproduction 2020, 35: 1296-1305. PMID: 32432326, PMCID: PMC7316499, DOI: 10.1093/humrep/deaa027.
Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomesChen V, Zhang H. Depth importance in precision medicine (DIPM): a tree- and forest-based method for right-censored survival outcomes. Biostatistics 2020, 23: 157-172. PMID: 32424406, PMCID: PMC8759439, DOI: 10.1093/biostatistics/kxaa021.
Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentrationYu Y, Zhao S, Li Y, Niu Y, Wei D, Zhang S, Chen ZJ, Zhang H, Legro RS. Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration. Reproductive BioMedicine Online 2020, 41: 395-401. PMID: 32600942, DOI: 10.1016/j.rbmo.2020.04.021.
OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized TrialLegro R, Hansen K, Diamond M, Steiner A, Mersereau J, Sarwer D, Kris-Etherton P, Wild R, Krawetz S, Hoeger K, Usadi R, Johnstone E, Hao H, Eisenberg E, Santoro N, Zhang H. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial. Journal Of The Endocrine Society 2020, 4: or11-04. PMCID: PMC7209215, DOI: 10.1210/jendso/bvaa046.2149.
Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropinsLegro RS, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Cedars MI, Hansen KR, Robinson R, Baker V, Usadi R, Dodson WC, Estes SJ, Kunselman A, Stetter C, Barnhart KT, Coward RM, Trussell JC, Krawetz SA, Santoro N, Huang H, Zhang H, Eisenberg E, Network R. Pregnancy registry: three-year follow-up of children conceived from letrozole, clomiphene, or gonadotropins. Fertility And Sterility 2020, 113: 1005-1013. PMID: 32386612, PMCID: PMC7376442, DOI: 10.1016/j.fertnstert.2019.12.023.
Relative Efficiency of Using Summary Versus Individual Data in Random-Effects Meta-AnalysisChen D, Liu D, Min X, Zhang H. Relative Efficiency of Using Summary Versus Individual Data in Random-Effects Meta-Analysis. Biometrics 2020, 76: 1319-1329. PMID: 32056197, PMCID: PMC7955582, DOI: 10.1111/biom.13238.
Androgenicity and fertility treatment in women with unexplained infertilityWang ET, Diamond MP, Alvero R, Casson P, Christman GM, Coutifaris C, Hansen KR, Sun F, Legro RS, Robinson RD, Usadi RS, Pisarska MD, Santoro NF, Zhang H, Network I. Androgenicity and fertility treatment in women with unexplained infertility. Fertility And Sterility 2020, 113: 636-641. PMID: 32192596, PMCID: PMC7088440, DOI: 10.1016/j.fertnstert.2019.10.034.
The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trialSteiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, Krawetz SA, Usadi R, Baker VL, Coward RM, Huang H, Wild R, Masson P, Smith JF, Santoro N, Eisenberg E, Zhang H, Network R. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility And Sterility 2020, 113: 552-560.e3. PMID: 32111479, PMCID: PMC7219515, DOI: 10.1016/j.fertnstert.2019.11.008.
Families with children resulting from ART: psychosocial and financial implicationsMiller V, Diamond MP, Hansen KR, Steiner AZ, Cedars M, Legro RS, Krawetz SA, Coutifaris C, Huang H, Santoro N, Zhang H, Network N. Families with children resulting from ART: psychosocial and financial implications. Human Reproduction Open 2020, 2020: hoaa010. PMID: 32309638, PMCID: PMC7152781, DOI: 10.1093/hropen/hoaa010.
Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomesBattarbee AN, Ros ST, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Varner MW, Manuck TA, Research E. Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomes. American Journal Of Obstetrics & Gynecology MFM 2019, 2: 100077. PMID: 32905377, PMCID: PMC7469940, DOI: 10.1016/j.ajogmf.2019.100077.
Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birthParry S, Leite R, Esplin MS, Bukowski R, Zhang H, Varner M, Andrews WW, Saade GR, Ilekis J, Reddy UM, Huang H, Sadovsky Y, Blair IA, Biggio J, Research E. Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth. American Journal Of Obstetrics And Gynecology 2019, 222: 493.e1-493.e13. PMID: 31758918, PMCID: PMC7196033, DOI: 10.1016/j.ajog.2019.11.1252.
Associations between anti-mullerian hormone and cardio-metabolic health in reproductive age women are explained by body mass indexRios JS, Greenwood EA, Pavone MEG, Cedars MI, Legro RS, Diamond MP, Santoro N, Sun F, Robinson RD, Christman G, Zhang H, Huddleston HG. Associations between anti-mullerian hormone and cardio-metabolic health in reproductive age women are explained by body mass index. The Journal Of Clinical Endocrinology & Metabolism 2019, 105: e555-e563. PMID: 31586179, PMCID: PMC7024739, DOI: 10.1210/clinem/dgz012.
Lower antimüllerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesityVitek W, Sun F, Baker VL, Styer AK, Christianson MS, Stern JE, Zhang H, Polotsky AJ. Lower antimüllerian hormone is associated with lower oocyte yield but not live-birth rate among women with obesity. American Journal Of Obstetrics And Gynecology 2019, 222: 363.e1-363.e7. PMID: 31589862, PMCID: PMC8022853, DOI: 10.1016/j.ajog.2019.09.046.
Paternal age is a predictor of elevated sperm DNA fragmentation in infertile menRios J, Coward R, Sun F, Zhang H, Santoro N, Steiner A. Paternal age is a predictor of elevated sperm DNA fragmentation in infertile men. Fertility And Sterility 2019, 112: e364-e365. DOI: 10.1016/j.fertnstert.2019.07.1044.
Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesitySwanson GM, Estill M, Diamond MP, Legro RS, Coutifaris C, Barnhart KT, Huang H, Hansen KR, Trussell JC, Coward RM, Zhang H, Goodrich R, Krawetz SA. Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity. Epigenetics 2019, 15: 32-46. PMID: 31354029, PMCID: PMC6961666, DOI: 10.1080/15592294.2019.1644880.
Fresh versus frozen blastocyst transfer – Authors' replyWei D, Zhang H, Legro RS, Chen ZJ. Fresh versus frozen blastocyst transfer – Authors' reply. The Lancet 2019, 394: 1228. PMID: 31303315, DOI: 10.1016/s0140-6736(19)31390-x.
Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility.Coward RM, Stetter C, Kunselman A, Trussell JC, Lindgren MC, Alvero RR, Casson P, Christman GM, Coutifaris C, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Robinson RD, Smith JF, Steiner AZ, Wild RA, Zhang H, Santoro N. Fertility Related Quality of Life, Gonadal Function and Erectile Dysfunction in Male Partners of Couples with Unexplained Infertility. Journal Of Urology 2019, 202: 379-384. PMID: 30835629, PMCID: PMC6686175, DOI: 10.1097/ju.0000000000000205.
Stats: P values akin to ‘beyond reasonable doubt’Zhang H. Stats: P values akin to ‘beyond reasonable doubt’. Nature 2019, 569: 336-336. PMID: 31097822, DOI: 10.1038/d41586-019-01530-x.
Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination populationTrussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Heisenleder D, Smith J, Steiner A, Wild R, Casson P, Coutifaris C, Alvero RR, Robinson RB, Christman G, Patrizio P, Zhang H, Lindgren MC, Network R. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility And Sterility 2019, 111: 1129-1134. PMID: 30982604, PMCID: PMC6557574, DOI: 10.1016/j.fertnstert.2019.01.034.
Common genetic variants have associations with human cortical brain regions and risk of schizophreniaBi X, Feng L, Wang S, Lin Z, Li T, Zhao B, Zhu H, Zhang H. Common genetic variants have associations with human cortical brain regions and risk of schizophrenia. Genetic Epidemiology 2019, 43: 548-558. PMID: 30941828, PMCID: PMC6559856, DOI: 10.1002/gepi.22203.
Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertilityHuang H, Kuang H, Sun F, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PR, Christman GM, Hansen KR, Santoro N, Eisenberg E, Zhang H, Network E. Lower prevalence of non–cavity-distorting uterine fibroids in patients with polycystic ovary syndrome than in those with unexplained infertility. Fertility And Sterility 2019, 111: 1011-1019.e1. PMID: 30926125, PMCID: PMC6487215, DOI: 10.1016/j.fertnstert.2019.01.020.
An accurate and powerful method for copy number variation detectionXiao F, Luo X, Hao N, Niu YS, Xiao X, Cai G, Amos CI, Zhang H. An accurate and powerful method for copy number variation detection. Bioinformatics 2019, 35: 2891-2898. PMID: 30649252, PMCID: PMC6735918, DOI: 10.1093/bioinformatics/bty1041.
Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependenceZhang H, Liu D, Zhao J, Bi X. Modeling hybrid traits for comorbidity and genetic studies of alcohol and nicotine co-dependence. The Annals Of Applied Statistics 2018, 12: 2359-2378. PMID: 30666272, PMCID: PMC6338437, DOI: 10.1214/18-aoas1156.
The efficiency of single institutional review board review in National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network–initiated clinical trialsDiamond MP, Eisenberg E, Huang H, Coutifaris C, Legro RS, Hansen KR, Steiner AZ, Cedars M, Barnhart K, Ziolek T, Thomas TR, Maurer K, Krawetz SA, Wild RA, Trussell J, Santoro N, Zhang H, Network F. The efficiency of single institutional review board review in National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network–initiated clinical trials. Clinical Trials 2018, 16: 3-10. PMID: 30354458, PMCID: PMC6384136, DOI: 10.1177/1740774518807888.
Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trialBarnhart KT, Sammel MD, Stephenson M, Robins J, Hansen KR, Youssef WA, Santoro N, Eisenberg E, Zhang H, Network F. Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial. Contemporary Clinical Trials 2018, 73: 145-151. PMID: 30243810, PMCID: PMC6231403, DOI: 10.1016/j.cct.2018.09.009.
Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndromeChristianson MS, Legro RS, Jin S, Eisenberg E, Diamond MP, Hansen KR, Vitek W, Styer AK, Casson P, Coutifaris C, Christman GM, Alvero R, Puscheck EE, Christy AY, Sun F, Zhang H, Polotsky AJ, Santoro N. Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome. Journal Of Assisted Reproduction And Genetics 2018, 35: 2173-2180. PMID: 30194618, PMCID: PMC6289919, DOI: 10.1007/s10815-018-1306-2.
Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertilityVitek W, Sun F, Hoeger K, Santoro N, Diamond M, Zhang H, Legro R. Weight gain during ovulation induction among women with polycystic ovary syndrome and unexplained infertility. Fertility And Sterility 2018, 110: e68. DOI: 10.1016/j.fertnstert.2018.07.207.
Individualized decision making in ovulation induction (OI)/ovulation stimulation (OS) cycles: can clinical outcome be predicted utilizing patient and cycle specific characteristics?Souter I, Legro R, Diamond M, Zhang H, Santoro N. Individualized decision making in ovulation induction (OI)/ovulation stimulation (OS) cycles: can clinical outcome be predicted utilizing patient and cycle specific characteristics? Fertility And Sterility 2018, 110: e102. DOI: 10.1016/j.fertnstert.2018.07.308.
Leftover embryos in the united states from 2004-2013: what factors are associated with embryos remaining cryopreserved?Christianson M, Stern J, Sun F, Zhang H, Polotsky A. Leftover embryos in the united states from 2004-2013: what factors are associated with embryos remaining cryopreserved? Fertility And Sterility 2018, 110: e227. DOI: 10.1016/j.fertnstert.2018.07.654.
Defining hypogonadism in male partners of couples with unexplained infertilityTrussell J, Coward R, Santoro N, Stetter C, Kunselman A, Diamond M, Hansen K, Krawetz S, Legro R, Smith J, Steiner A, Wild R, Zhang H, Lindgren M. Defining hypogonadism in male partners of couples with unexplained infertility. Fertility And Sterility 2018, 110: e296. DOI: 10.1016/j.fertnstert.2018.07.833.
Is anti-mullerian hormone a marker for cardio-metabolic health in reproductive age eumenorrheic women?Sroga-Rios J, Greenwood E, Huddleston H, Cedars M, Diamond M, Zhang H, Santoro N, Pavone M. Is anti-mullerian hormone a marker for cardio-metabolic health in reproductive age eumenorrheic women? Fertility And Sterility 2018, 110: e326. DOI: 10.1016/j.fertnstert.2018.07.915.
Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility.Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.
Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theoryCherskov A, Pohl A, Allison C, Zhang H, Payne RA, Baron-Cohen S. Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory. Translational Psychiatry 2018, 8: 136. PMID: 30065244, PMCID: PMC6068102, DOI: 10.1038/s41398-018-0186-7.
Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertilityBarrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Human Reproduction 2018, 33: 1757-1766. PMID: 30085177, PMCID: PMC6454470, DOI: 10.1093/humrep/dey261.
Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled StudyKent J, Dodson WC, Kunselman A, Pauli J, Stone A, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Rosen RM, Hansen KR, Robinson R, Baker V, Usadi R, Santoro N, Zhang H, Eisenberg E, Legro RS. Gestational Weight Gain in Women With Polycystic Ovary Syndrome: A Controlled Study. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 4315-4323. PMID: 30085187, PMCID: PMC6194806, DOI: 10.1210/jc.2017-02764.
Letter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”Diamond MP, Huang H, Gracia C, Santoro N, Zhang H. Letter to the Editor: “Higher TSH Levels Within the Normal Range Are Associated With Unexplained Infertility”. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 3110-3111. PMID: 29889234, PMCID: PMC6692707, DOI: 10.1210/jc.2018-00704.
Ball Divergence: Nonparametric two sample testPan W, Tian Y, Wang X, Zhang H. Ball Divergence: Nonparametric two sample test. The Annals Of Statistics 2018, 46: 1109-1137. PMID: 30344356, PMCID: PMC6192286, DOI: 10.1214/17-aos1579.
A univariate perspective of multivariate genome‐wide association analysisGuo X, Zhu J, Fan Q, He M, Wang X, Zhang H. A univariate perspective of multivariate genome‐wide association analysis. Genetic Epidemiology 2018, 42: 470-479. PMID: 29781551, DOI: 10.1002/gepi.22128.
Midluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained InfertilityHansen KR, Eisenberg E, Baker V, Hill MJ, Chen S, Talken S, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H, Wild RA. Midluteal Progesterone: A Marker of Treatment Outcomes in Couples With Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2743-2751. PMID: 29767754, PMCID: PMC6276712, DOI: 10.1210/jc.2018-00642.
Data Do Not Support Effectiveness of Acupuncture for Improving Live Birth Rate in Women with Polycystic Ovary Syndrome.Kuang HY, Li Y, Zhang HP, Legro RS, Stener-Victorin E. Data Do Not Support Effectiveness of Acupuncture for Improving Live Birth Rate in Women with Polycystic Ovary Syndrome. Chinese Journal Of Integrative Medicine 2018, 24: 399-400. PMID: 29752614, DOI: 10.1007/s11655-018-2842-4.
Major depression, antidepressant use, and male and female fertilityEvans-Hoeker EA, Eisenberg E, Diamond MP, Legro RS, Alvero R, Coutifaris C, Casson PR, Christman GM, Hansen KR, Zhang H, Santoro N, Steiner AZ, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Ager J, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Lecks K, Martino L, Marunich R, Comfort A, Crow M, Hohmann A, Mallette S, Smith Y, Randolph J, Fisseha S, Ohl D, Ringbloom M, Tang J, Bates W, Mason S, Craig L, Zornes C, Rodriguez M, Hunt T, DiMaria N, Usadi R, Lucidi S, Rhea M, Baker V, Turner K, Brennan M, DelBasso D, Huang H, Jin Y, Li Y, Kuang H, Makuch R, Patrizio P, Sakai L, Scahill L, Song C, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Trussell J, Laylor B, Martinez L, Solnica A, Wojtczuk A, Seungdamrong A, Rosen M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Major depression, antidepressant use, and male and female fertility. Fertility And Sterility 2018, 109: 879-887. PMID: 29778387, PMCID: PMC5973807, DOI: 10.1016/j.fertnstert.2018.01.029.
The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory WomenWei D, Yu Y, Sun M, Shi Y, Sun Y, Deng X, Li J, Wang Z, Zhao S, Zhang H, Legro RS, Chen ZJ. The Effect of Supraphysiological Estradiol on Pregnancy Outcomes Differs Between Women With PCOS and Ovulatory Women. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2735-2742. PMID: 29718297, DOI: 10.1210/jc.2018-00613.
Residuals and Diagnostics for Ordinal Regression Models: A Surrogate ApproachLiu D, Zhang H. Residuals and Diagnostics for Ordinal Regression Models: A Surrogate Approach. Journal Of The American Statistical Association 2018, 113: 845-854. PMID: 30220754, PMCID: PMC6133273, DOI: 10.1080/01621459.2017.1292915.
MP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITYCoward R, Stetter C, Kunselman A, Trussell J, Lindgren M, Diamond M, Hansen K, Krawetz S, Legro R, Patrizio P, Smith J, Steiner A, Wild R, Eisenberg E, Zhang H, Santoro N. MP19-14 FERTILITY-RELATED QUALITY OF LIFE, GONADAL FUNCTION, AND ERECTILE DYSFUNCTION IN MALE PARTNERS OF COUPLES WITH UNEXPLAINED INFERTILITY. Journal Of Urology 2018, 199: e249. DOI: 10.1016/j.juro.2018.02.663.
PD49-11 METABOLIC DYSFUNCTION AND HYPOGONADISM IN A COHORT OF YOUNG, HEALTHY MENLindgren M, Stetter C, Kunselman A, Coward R, Diamond M, Hansen K, Krawetz S, Legro R, Smith J, Steiner A, Patrizio P, Wild B, Eisenberg E, Zhang H, Santoro N, Trussell J. PD49-11 METABOLIC DYSFUNCTION AND HYPOGONADISM IN A COHORT OF YOUNG, HEALTHY MEN. Journal Of Urology 2018, 199: e969. DOI: 10.1016/j.juro.2018.02.2327.
MP60-16 HYPOGONADISM IS ASSOCIATED WITH LOWER SPERM MORPHOLOGY AND LOWER LIVE BIRTH RATES IN MEN WITH UNEXPLAINED INFERTILITYTrussell J, Coward R, Santoro N, Stetter C, Kunselman A, Diamond M, Hansen K, Krawetz S, Legro R, Smith J, Steiner A, Patrizio P, Wild R, Eisenberg E, Zhang H, Lindgren M. MP60-16 HYPOGONADISM IS ASSOCIATED WITH LOWER SPERM MORPHOLOGY AND LOWER LIVE BIRTH RATES IN MEN WITH UNEXPLAINED INFERTILITY. Journal Of Urology 2018, 199: e796. DOI: 10.1016/j.juro.2018.02.1908.
Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validationBarnhart K, Giudice L, Young S, Thomas T, Diamond MP, Segars J, Youssef WA, Krawetz S, Santoro N, Eisenberg E, Zhang H, Network F. Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation. Contemporary Clinical Trials 2018, 68: 1-6. PMID: 29524590, PMCID: PMC5899676, DOI: 10.1016/j.cct.2018.03.002.
Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary SyndromeWei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro R, Zhang H, Chen Z. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2018, 73: 158-159. DOI: 10.1097/01.ogx.0000532005.07471.0c.
Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction.Li J, Wu Q, Wu XK, Zhou ZM, Fu P, Chen XH, Yan Y, Wang X, Yang ZW, Li WL, Stener-Victorin E, Legro RS, Ng EH, Zhang H, Mol BWJ, Wang CC. Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction. Human Reproduction 2018, 33: 617-625. PMID: 29471520, DOI: 10.1093/humrep/dey027.
Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohortWen C, Mehta CM, Tan H, Zhang H. Whole genome association study of brain‐wide imaging phenotypes: A study of the ping cohort. Genetic Epidemiology 2018, 42: 265-275. PMID: 29411414, PMCID: PMC5851842, DOI: 10.1002/gepi.22111.
Subtype Classification and Heterogeneous Prognosis Model Construction in Precision MedicineYou N, He S, Wang X, Zhu J, Zhang H. Subtype Classification and Heterogeneous Prognosis Model Construction in Precision Medicine. Biometrics 2018, 74: 814-822. PMID: 29359319, DOI: 10.1111/biom.12843.
Challenges in analyzing time to live birthKuang H, Huang H, Tan H, Kunselman A, Zhang H. Challenges in analyzing time to live birth. Statistics And Its Interface 2018, 11: 397-399. DOI: 10.4310/sii.2018.v11.n2.a15.
Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile womenSeungdamrong A, Steiner AZ, Gracia CR, Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Robinson RD, Huang H, Alvero R, Hansen KR, Jin S, Eisenberg E, Zhang H, Santoro N, Network E. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Fertility And Sterility 2017, 108: 843-850. PMID: 29102040, PMCID: PMC8129952, DOI: 10.1016/j.fertnstert.2017.08.026.
Acupuncture for Infertility in Polycystic Ovary Syndrome—ReplyWu XK, Stener-Victorin E, Zhang H. Acupuncture for Infertility in Polycystic Ovary Syndrome—Reply. JAMA 2017, 318: 1502-1502. PMID: 29049650, DOI: 10.1001/jama.2017.13394.
Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interfaceBukowski R, Sadovsky Y, Goodarzi H, Zhang H, Biggio JR, Varner M, Parry S, Xiao F, Esplin SM, Andrews W, Saade GR, Ilekis JV, Reddy UM, Baldwin DA. Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. PeerJ 2017, 5: e3685. PMID: 28879060, PMCID: PMC5582610, DOI: 10.7717/peerj.3685.
Frozen versus fresh embryo transfer in ovulatory womenChen Z, Shi Y, Wei D, Zhang H, Wang Z, Li J, Legro R. Frozen versus fresh embryo transfer in ovulatory women. Fertility And Sterility 2017, 108: e166-e167. DOI: 10.1016/j.fertnstert.2017.07.500.
Factors associated with freeze-all embryo cycles in the United States from 2004-2013Christianson M, Stern J, Sun F, Zhang H, Styer A, Polotsky A. Factors associated with freeze-all embryo cycles in the United States from 2004-2013. Fertility And Sterility 2017, 108: e88-e89. DOI: 10.1016/j.fertnstert.2017.07.275.
Predictive factors for adherence to study protocol in infertility treatment trialsEngmann L, Sun F, Eisenberg E, Coutifaris C, Zhang H, Santoro N, Network R. Predictive factors for adherence to study protocol in infertility treatment trials. Fertility And Sterility 2017, 108: e89-e90. DOI: 10.1016/j.fertnstert.2017.07.278.
Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome.Wei D, Zhang B, Shi Y, Zhang L, Zhao S, Du Y, Xu L, Legro RS, Zhang H, Chen ZJ. Effect of Preconception Impaired Glucose Tolerance on Pregnancy Outcomes in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2017, 102: 3822-3829. PMID: 28938429, DOI: 10.1210/jc.2017-01294.
Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical TrialWu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, Hou LH, Hu ZX, Shao XG, Ge J, Zhang JF, Xue HY, Xu XF, Liang RN, Ma HX, Yang HW, Li WL, Huang DM, Sun Y, Hao CF, Du SM, Yang ZW, Wang X, Yan Y, Chen XH, Fu P, Ding CF, Gao YQ, Zhou ZM, Wang CC, Wu TX, Liu JP, Ng EHY, Legro RS, Zhang H. Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial. JAMA 2017, 317: 2502-2514. PMID: 28655015, PMCID: PMC5815063, DOI: 10.1001/jama.2017.7217.
Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypesBi X, Yang L, Li T, Wang B, Zhu H, Zhang H. Genome‐wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes. Human Brain Mapping 2017, 38: 4088-4097. PMID: 28544218, PMCID: PMC5568842, DOI: 10.1002/hbm.23650.
Sexual function in infertile women with polycystic ovary syndrome and unexplained infertilityDiamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PA, Christman GM, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Schlaff W, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Santoro N, Eisenberg E, Zhang H, Network E. Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility. American Journal Of Obstetrics And Gynecology 2017, 217: 191.e1-191.e19. PMID: 28455078, PMCID: PMC5657185, DOI: 10.1016/j.ajog.2017.04.034.
modSaRa: a computationally efficient R package for CNV identification.Xiao F, Niu Y, Hao N, Xu Y, Jin Z, Zhang H. modSaRa: a computationally efficient R package for CNV identification. Bioinformatics 2017, 33: 2384-2385. PMID: 28453611, PMCID: PMC5860124, DOI: 10.1093/bioinformatics/btx212.
Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotypeEngmann L, Jin S, Sun F, Legro RS, Polotsky AJ, Hansen KR, Coutifaris C, Diamond MP, Eisenberg E, Zhang H, Santoro N, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Alvero R, Comfort A, Crow M, Schlaff W, Casson P, Hohmann A, Mallette S, Christman G, Ohl D, Ringbloom M, Tang J, Bates G, Mason S, DiMaria N, Usadi R, Lucidi R, Rhea M, Baker V, Turner K, Trussell J, DelBasso D, Huang H, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. American Journal Of Obstetrics And Gynecology 2017, 216: 493.e1-493.e13. PMID: 28104402, PMCID: PMC5420474, DOI: 10.1016/j.ajog.2017.01.003.
Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertilityStyer AK, Jin S, Liu D, Wang B, Polotsky AJ, Christianson MS, Vitek W, Engmann L, Hansen K, Wild R, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Christy A, Diamond MP, Eisenberg E, Zhang H, Santoro N, Network I. Association of uterine fibroids and pregnancy outcomes after ovarian stimulation–intrauterine insemination for unexplained infertility. Fertility And Sterility 2017, 107: 756-762.e3. PMID: 28089575, PMCID: PMC5472203, DOI: 10.1016/j.fertnstert.2016.12.012.
Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome.Wei D, Shi Y, Li J, Wang Z, Zhang L, Sun Y, Zhou H, Xu Y, Wu C, Liu L, Wu Q, Zhuang L, Du Y, Li W, Zhang H, Legro RS, Chen ZJ. Effect of pretreatment with oral contraceptives and progestins on IVF outcomes in women with polycystic ovary syndrome. Human Reproduction 2016, 32: 354-361. PMID: 27999118, PMCID: PMC5870982, DOI: 10.1093/humrep/dew325.
The screening and ranking algorithm for change-points detection in multiple samplesSong C, Min X, Zhang H. The screening and ranking algorithm for change-points detection in multiple samples. The Annals Of Applied Statistics 2016, 10: 2102-2129. PMID: 28090239, PMCID: PMC5233178, DOI: 10.1214/16-aoas966.
A method for integrating neuroimaging into genetic models of learning performanceMehta CM, Gruen JR, Zhang H. A method for integrating neuroimaging into genetic models of learning performance. Genetic Epidemiology 2016, 41: 4-17. PMID: 27859682, PMCID: PMC5154929, DOI: 10.1002/gepi.22025.
Multiple Change-Point Detection: A Selective OverviewNiu Y, Hao N, Zhang H. Multiple Change-Point Detection: A Selective Overview. Statistical Science 2016, 31: 611-623. DOI: 10.1214/16-sts587.
Segregation Analysis Suggests That a Genetic Reason May Contribute to “the Dress” Colour PerceptionXiao F, Cai G, Zhang H. Segregation Analysis Suggests That a Genetic Reason May Contribute to “the Dress” Colour Perception. PLOS ONE 2016, 11: e0165095. PMID: 27768729, PMCID: PMC5074562, DOI: 10.1371/journal.pone.0165095.
Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival EndpointsHan G, Schell MJ, Zhang H, Zelterman D, Pusztai L, Adelson K, Hatzis C. Testing Violations of the Exponential Assumption in Cancer Clinical Trials with Survival Endpoints. Biometrics 2016, 73: 687-695. PMID: 27669414, PMCID: PMC6093291, DOI: 10.1111/biom.12590.
Academic productivity in the Clinical Research/Reproductive Endocrine Scientist Training Program (CREST): A 10-year appraisalSantoro N, Usadi R, Christy A, Polotsky A, Zhang H. Academic productivity in the Clinical Research/Reproductive Endocrine Scientist Training Program (CREST): A 10-year appraisal. Fertility And Sterility 2016, 106: e246-e247. DOI: 10.1016/j.fertnstert.2016.07.711.
Acupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trialWu X, Stener-Victorin E, Liu J, Wu T, Ng E, Legro R, Zhang H. Acupuncture and clomiphene for infertility in the polycystic ovary syndrome: a multicentre rondomized controlled trial. Fertility And Sterility 2016, 106: e375. DOI: 10.1016/j.fertnstert.2016.08.002.
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary SyndromeChen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2016, 375: 523-533. PMID: 27509101, DOI: 10.1056/nejmoa1513873.
Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndromeSantoro N, Eisenberg E, Trussell JC, Craig LB, Gracia C, Huang H, Alvero R, Casson P, Christman G, Coutifaris C, Diamond M, Jin S, Legro RS, Robinson RD, Schlaff WD, Zhang H. Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndrome. Human Reproduction 2016, 31: 2268-2279. PMID: 27402910, PMCID: PMC5027926, DOI: 10.1093/humrep/dew175.
Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary SyndromeMumford SL, Legro RS, Diamond MP, Coutifaris C, Steiner AZ, Schlaff WD, Alvero R, Christman GM, Casson PR, Huang H, Santoro N, Eisenberg E, Zhang H, Cedars MI. Baseline AMH Level Associated With Ovulation Following Ovulation Induction in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 3288-3296. PMID: 27228369, PMCID: PMC5010565, DOI: 10.1210/jc.2016-1340.
Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled TrialPal L, Zhang H, Williams J, Santoro NF, Diamond MP, Schlaff WD, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers E, Legro RS, Network F. Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 3027-3035. PMID: 27186859, PMCID: PMC4971341, DOI: 10.1210/jc.2015-4352.
Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOSLegro RS, Dodson WC, Kunselman AR, Stetter CM, Kris-Etherton PM, Williams NI, Gnatuk CL, Estes SJ, Allison KC, Sarwer DB, Diamond MP, Schlaff WD, Casson PR, Christman GM, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Zhang H, Eisenberg E, Coutifaris C, Dokras A. Benefit of Delayed Fertility Therapy With Preconception Weight Loss Over Immediate Therapy in Obese Women With PCOS. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 2658-2666. PMID: 27172435, PMCID: PMC4929837, DOI: 10.1210/jc.2016-1659.
Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine inseminationHansen KR, He AL, Styer AK, Wild RA, Butts S, Engmann L, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Huang H, Santoro N, Eisenberg E, Zhang H, Network E. Predictors of pregnancy and live-birth in couples with unexplained infertility after ovarian stimulation–intrauterine insemination. Fertility And Sterility 2016, 105: 1575-1583.e2. PMID: 26949110, PMCID: PMC4893990, DOI: 10.1016/j.fertnstert.2016.02.020.
Variable Selection With Prior Information for Generalized Linear Models via the Prior LASSO MethodJiang Y, He Y, Zhang H. Variable Selection With Prior Information for Generalized Linear Models via the Prior LASSO Method. Journal Of The American Statistical Association 2016, 111: 355-376. PMID: 27217599, PMCID: PMC4874534, DOI: 10.1080/01621459.2015.1008363.
242: Gene set enrichment investigation of maternal exome variation in spontaneous preterm birth (SPTB)Manuck T, Watkins S, Esplin M, Parry S, Zhang H, Huang H, Biggio J, Bukowski R, Saade G, Andrews W, Baldwin D, Sadovsky Y, Reddy U, Ilekis J, Varner M, Jorde L, Yandell M. 242: Gene set enrichment investigation of maternal exome variation in spontaneous preterm birth (SPTB). American Journal Of Obstetrics And Gynecology 2016, 214: s142-s143. DOI: 10.1016/j.ajog.2015.10.280.
12: Genetic variation may influence response to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth (PTB) preventionManuck T, Watkins S, Esplin M, Parry S, Zhang H, Huang H, Biggio J, Bukowski R, Saade G, Andrews W, Baldwin D, Sadovsky Y, Reddy U, Ilekis J, Varner M, Yandell M, Jorde L. 12: Genetic variation may influence response to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth (PTB) prevention. American Journal Of Obstetrics And Gynecology 2016, 214: s9-s10. DOI: 10.1016/j.ajog.2015.10.034.
528: Optimal duration of antenatal corticosteroid (ACS) exposure and neonatal outcomesRomero S, Esplin M, Parry S, Zhang H, Huang H, Biggio J, Bukowski R, Saade G, Andrews W, Baldwin D, Sadovsky Y, Reddy U, Ilekis J, Varner M, Manuck T. 528: Optimal duration of antenatal corticosteroid (ACS) exposure and neonatal outcomes. American Journal Of Obstetrics And Gynecology 2016, 214: s285-s286. DOI: 10.1016/j.ajog.2015.10.572.
Energy bagging tree.Cao T, Wang X, Zhang H. Energy bagging tree. Statistics And Its Interface 2016, 9: 171-181. PMID: 26594301, PMCID: PMC4648255, DOI: 10.4310/sii.2016.v9.n2.a5.
Modeling Multiple Responses via Bootstrapping Margins with an Application to Genetic Association Testing.Zhao J, Zhang H. Modeling Multiple Responses via Bootstrapping Margins with an Application to Genetic Association Testing. Statistics And Its Interface 2016, 9: 47-56. PMID: 26543519, PMCID: PMC4629876, DOI: 10.4310/sii.2016.v9.n1.a5.
A modified classification tree method for personalized medicine decisions.Tsai WM, Zhang H, Buta E, O'Malley S, Gueorguieva R. A modified classification tree method for personalized medicine decisions. Statistics And Its Interface 2016, 9: 239-253. PMID: 26770292, PMCID: PMC4707681, DOI: 10.4310/sii.2016.v9.n2.a11.
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birthManuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.
Letrozole, Gonadotropin, or Clomiphene for Unexplained InfertilityDiamond M, Legro R, Coutifaris C, Alvero R, Robinson R, Casson P, Christman G, Ager J, Huang H, Hansen K, Baker V, Usadi R, Seungdamrong A, Bates G, Rosen R, Haisenleder D, Krawetz S, Barnhart K, Trussell J, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. Obstetrical & Gynecological Survey 2015, 70: 757-758. DOI: 10.1097/ogx.0000000000000275.
Genes and environment in neonatal intraventricular hemorrhageMent LR, Ådén U, Bauer CR, Bada HS, Carlo WA, Kaiser JR, Lin A, Cotten CM, Murray J, Page G, Hallman M, Lifton RP, Zhang H, Network O. Genes and environment in neonatal intraventricular hemorrhage. Seminars In Perinatology 2015, 39: 592-603. PMID: 26516117, PMCID: PMC4668116, DOI: 10.1053/j.semperi.2015.09.006.
Association Tests of Multiple Phenotypes: ATeMPGuo X, Li Y, Ding X, He M, Wang X, Zhang H. Association Tests of Multiple Phenotypes: ATeMP. PLOS ONE 2015, 10: e0140348. PMID: 26479245, PMCID: PMC4610695, DOI: 10.1371/journal.pone.0140348.
Conditional Distance CorrelationWang X, Pan W, Hu W, Tian Y, Zhang H. Conditional Distance Correlation. Journal Of The American Statistical Association 2015, 110: 1726-1734. PMID: 26877569, PMCID: PMC4749041, DOI: 10.1080/01621459.2014.993081.
Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubesSteiner AZ, Diamond MP, Legro RS, Schlaff WD, Barnhart KT, Casson PR, Christman GM, Alvero R, Hansen KR, Geisler WM, Thomas T, Santoro N, Zhang H, Eisenberg E, Network R. Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes. Fertility And Sterility 2015, 104: 1522-1526. PMID: 26413816, PMCID: PMC4663111, DOI: 10.1016/j.fertnstert.2015.08.022.
Letrozole, Gonadotropin, or Clomiphene for Unexplained InfertilityDiamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Ohl D, Jin Y, Santoro N, Eisenberg E, Zhang H. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. New England Journal Of Medicine 2015, 373: 1230-1240. PMID: 26398071, PMCID: PMC4739644, DOI: 10.1056/nejmoa1414827.
Recruitment strategies in two reproductive medicine network infertility trialsUsadi RS, Diamond MP, Legro RS, Schlaff WD, Hansen KR, Casson P, Christman G, Bates G, Baker V, Seungdamrong A, Rosen MP, Lucidi S, Thomas T, Huang H, Santoro N, Eisenberg E, Zhang H, Alvero R, Network F. Recruitment strategies in two reproductive medicine network infertility trials. Contemporary Clinical Trials 2015, 45: 196-200. PMID: 26386293, PMCID: PMC4766588, DOI: 10.1016/j.cct.2015.09.010.
Predictors of participant retention in infertility treatment trialsKuang H, Jin S, Thomas T, Engmann L, Hansen KR, Coutifaris C, Casson P, Christman G, Alvero R, Santoro N, Eisenberg E, Diamond MP, Legro RS, Zhang H, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Easton C, Hernandez A, Leija M, Pierce D, Bryzski R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Schlaff W, Comfort A, Crow M, Hohmann A, Mallette S, Ringbloom M, Tang J, Mason S, DiMaria N, Rhea M, Turner K, Haisenleder D, Trussell J, DelBasso D, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Zhang M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Predictors of participant retention in infertility treatment trials. Fertility And Sterility 2015, 104: 1236-1243.e2. PMID: 26354094, PMCID: PMC4630082, DOI: 10.1016/j.fertnstert.2015.08.001.
Male obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trialPolotsky A, Allshouse A, Krawetz S, Santoro N, Eisenberg E, Zhang H, Diamond M. Male obesity is an independent risk factor for treatment failure among couples with unexplained infertility in the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Fertility And Sterility 2015, 104: e78. DOI: 10.1016/j.fertnstert.2015.07.238.
Utility of sonohysterography for tubal patency assessment in the pregnancy in polycystic ovary syndrome II trialChristianson M, Legro R, Jin S, Eisenberg E, Diamond M, Hansen K, Vitek W, Styer A, Casson P, Coutifaris C, Christman G, Alvero R, Puscheck E, Christy A, Zhang H, Polotsky A, Santoro N. Utility of sonohysterography for tubal patency assessment in the pregnancy in polycystic ovary syndrome II trial. Fertility And Sterility 2015, 104: e98-e99. DOI: 10.1016/j.fertnstert.2015.07.304.
Antithyroid antibodies, but not thyroid stimulating hormone, are associated with decreased pregnancy rates in infertile womenSeungdamrong A, Steiner A, Gracia C, Diamond M, Legro R, Jin S, Eisenberg E, Zhang H, Santoro N. Antithyroid antibodies, but not thyroid stimulating hormone, are associated with decreased pregnancy rates in infertile women. Fertility And Sterility 2015, 104: e36-e37. DOI: 10.1016/j.fertnstert.2015.07.111.
Abstract 4626: Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populationsRothman N, Bassig B, Cerhan J, Au W, Kim H, Sangrajrang S, Hu W, Tse J, Berndt S, Zheng T, Zhang H, Pornsopone P, Lee J, Kim H, Skibola C, Vijai J, Burdette L, Yeager M, Brennan P, Shin M, Liang R, Chanock S, Lan Q. Abstract 4626: Genetic susceptibility to diffuse large B-cell lymphoma in a pooled study of three Eastern Asian populations. 2015, 4626-4626. DOI: 10.1158/1538-7445.am2015-4626.
Abstract 846: Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in a pooled analysis of three prospective cohorts of Chinese men and women in Shanghai and SingaporeBassig B, Shu X, Koh W, Gao Y, Purdue M, Butler L, Adams-Haduch J, Xiang Y, Kemp T, Wang R, Pinto L, Zheng T, Ji B, Hosgood H, Hu W, Yang G, Zhang H, Chow W, Kim C, Seow W, Zheng W, Yuan J, Lan Q, Rothman N. Abstract 846: Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in a pooled analysis of three prospective cohorts of Chinese men and women in Shanghai and Singapore. 2015, 846-846. DOI: 10.1158/1538-7445.am2015-846.
Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndromeKuang H, Jin S, Hansen KR, Diamond MP, Coutifaris C, Casson P, Christman G, Alvero R, Huang H, Bates GW, Usadi R, Lucidi S, Baker V, Santoro N, Eisenberg E, Legro RS, Zhang H, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Easton C, Hernandez A, Leija M, Pierce D, Bryzski R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Schlaff W, Comfort A, Crow M, Hohmann A, Mallette S, Ringbloom M, Tang J, Mason S, DiMaria N, Rhea M, Turner K, Haisenleder D, Trussell J, DelBasso D, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Zhang M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Identification and replication of prediction models for ovulation, pregnancy and live birth in infertile women with polycystic ovary syndrome. Human Reproduction 2015, 30: 2222-2233. PMID: 26202922, PMCID: PMC4542721, DOI: 10.1093/humrep/dev182.
Soluble levels of CD27 and CD30 are associated with risk of non‐Hodgkin lymphoma in three Chinese prospective cohortsBassig BA, Shu XO, Koh WP, Gao YT, Purdue MP, Butler LM, Adams-Haduch J, Xiang YB, Kemp TJ, Wang R, Pinto LA, Zheng T, Ji BT, Hosgood HD, Hu W, Yang G, Zhang H, Chow WH, Kim C, Seow WJ, Zheng W, Yuan JM, Lan Q, Rothman N. Soluble levels of CD27 and CD30 are associated with risk of non‐Hodgkin lymphoma in three Chinese prospective cohorts. International Journal Of Cancer 2015, 137: 2688-2695. PMID: 26095604, PMCID: PMC4898881, DOI: 10.1002/ijc.29637.
TREE-BASED METHODSZHANG H. TREE-BASED METHODS. 2015, 1413-1429. DOI: 10.1142/9789814583312_0036.
An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosateGueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanismsEsplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 213: 429.e1-429.e9. PMID: 26070700, PMCID: PMC4556543, DOI: 10.1016/j.ajog.2015.06.011.
Subgroup Identification in Personalized Treatment of Alcohol DependenceHou J, Seneviratne C, Su X, Taylor J, Johnson B, Wang XQ, Zhang H, Kranzler HR, Kang J, Liu L. Subgroup Identification in Personalized Treatment of Alcohol Dependence. Alcohol Clinical And Experimental Research 2015, 39: 1253-1259. PMID: 26031187, PMCID: PMC4491003, DOI: 10.1111/acer.12759.
Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome.Polotsky AJ, Allshouse AA, Casson PR, Coutifaris C, Diamond MP, Christman GM, Schlaff WD, Alvero R, Trussell JC, Krawetz SA, Santoro N, Eisenberg E, Zhang H, Legro RS. Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 2405-12. PMID: 25856211, PMCID: PMC4454812, DOI: 10.1210/jc.2015-1178.
Genetic susceptibility to diffuse large B‐cell lymphoma in a pooled study of three Eastern Asian populationsBassig BA, Cerhan JR, Au WY, Kim HN, Sangrajrang S, Hu W, Tse J, Berndt S, Zheng T, Zhang H, Pornsopone P, Lee JJ, Kim HJ, Skibola CF, Vijai J, Burdette L, Yeager M, Brennan P, Shin MH, Liang R, Chanock S, Lan Q, Rothman N. Genetic susceptibility to diffuse large B‐cell lymphoma in a pooled study of three Eastern Asian populations. European Journal Of Haematology 2015, 95: 442-448. PMID: 25611436, DOI: 10.1111/ejh.12513.
Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health StudyBassig BA, Friesen MC, Vermeulen R, Shu XO, Purdue MP, Stewart PA, Xiang YB, Chow WH, Zheng T, Ji BT, Yang G, Linet MS, Hu W, Zhang H, Zheng W, Gao YT, Rothman N, Lan Q. Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study. Environmental Health Perspectives 2015, 123: 971-977. PMID: 25748391, PMCID: PMC4590744, DOI: 10.1289/ehp.1408307.
Assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial: baseline characteristicsDiamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Ager J, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Haisonleder D, Krawetz SA, Barnhart K, Trussell JC, Jin Y, Santoro N, Eisenberg E, Zhang H, Network I. Assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial: baseline characteristics. Fertility And Sterility 2015, 103: 962-973.e4. PMID: 25707331, PMCID: PMC4529113, DOI: 10.1016/j.fertnstert.2014.12.130.
The phenotype of spontaneous preterm birth: application of a clinical phenotyping toolManuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.
A Genome‐Wide Association Study of Early Spontaneous Preterm DeliveryZhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.
879: Predictors of recurrent spontaneous preterm birth (R-SPTB): a longitudinal cohortManuck T, Esplin M, Biggio J, Parry S, Zhang H, Bukowski R, Saade G, Sadovsky Y, Baldwin D, Andrews W, Huang H, Reddy U, Ilekis J, Varner M. 879: Predictors of recurrent spontaneous preterm birth (R-SPTB): a longitudinal cohort. American Journal Of Obstetrics And Gynecology 2015, 212: s418-s419. DOI: 10.1016/j.ajog.2014.10.1085.
101: Cervicovaginal fluid proteomic analysis identifies multiple potential biomarkers for preterm birthBiggio J, Zhang S, Parry S, Esplin M, Bukowski R, Zhang H, Varner M, Andrews W, Saade G, Huang H, Ilekis J, Reddy U, Sadovsky Y, Blair I. 101: Cervicovaginal fluid proteomic analysis identifies multiple potential biomarkers for preterm birth. American Journal Of Obstetrics And Gynecology 2015, 212: s68. DOI: 10.1016/j.ajog.2014.10.147.
560: Predictors of response to 17-alpha hydroxyprogesterone caproate (17P) for prevention of recurrent spontaneous preterm birth (SPTB)Manuck T, Esplin M, Parry S, Zhang H, Biggio J, Bukowski R, Saade G, Sadovsky Y, Baldwin D, Andrews W, Huang H, Reddy U, Ilekis J, Varner M. 560: Predictors of response to 17-alpha hydroxyprogesterone caproate (17P) for prevention of recurrent spontaneous preterm birth (SPTB). American Journal Of Obstetrics And Gynecology 2015, 212: s279. DOI: 10.1016/j.ajog.2014.10.606.
14: The phenotype of spontaneous preterm birth: application of a clinical phenotyping toolEsplin M, Manuck T, Biggio J, Bukowski R, Parry S, Zhang H, Varner M, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J. 14: The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: s11. DOI: 10.1016/j.ajog.2014.10.060.
187: Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations between preterm birth mechanismsEsplin M, Manuck T, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Varner M, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J. 187: Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations between preterm birth mechanisms. American Journal Of Obstetrics And Gynecology 2015, 212: s107-s108. DOI: 10.1016/j.ajog.2014.10.233.
9: Neonatal, not maternal, copy number variants are associated with spontaneous preterm birthBiggio J, Xiao F, Baldwin D, Bukowski R, Parry S, Esplin M, Andrews W, Saade G, Varner M, Sadovsky Y, Reddy U, Ilekis J, Zhang H. 9: Neonatal, not maternal, copy number variants are associated with spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 212: s8. DOI: 10.1016/j.ajog.2014.10.055.
Modified screening and ranking algorithm for copy number variation detectionXiao F, Min X, Zhang H. Modified screening and ranking algorithm for copy number variation detection. Bioinformatics 2014, 31: 1341-1348. PMID: 25542927, PMCID: PMC4410664, DOI: 10.1093/bioinformatics/btu850.
Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotypeLegro RS, Chen G, Kunselman AR, Schlaff WD, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Foulds J, Barnhart K, Martino L, Timbers K, Lambe L, DeWire R, Yang H, Bodine C, Mark D, Puscheck E, Ginsburg K, Collins K, Brossoit M, Leach R, Yelian F, Perez M, Buster J, Amato P, Torres M, Dodson W, Gnatuk C, Ober J, Demers L, Heller D, Colon J, Weiss G, Solnica A, Gatlin K, Hahn S, Roark M, Blackwell R, Willis V, Love L, Laychak K, Nazmy M, Stovall D, Evans W, Turner K, Chang J, Malcolm P, Coddington C, Permanente K, Faber K, Hasenleider D, Huang H. Smoking in infertile women with polycystic ovary syndrome: baseline validation of self-report and effects on phenotype. Human Reproduction 2014, 29: 2680-2686. PMID: 25324541, PMCID: PMC4227579, DOI: 10.1093/humrep/deu239.
Letrozole or Clomiphene for Infertility in the Polycystic Ovary SyndromeLegro RS, Zhang H. Letrozole or Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 1462-1464. PMID: 25295506, DOI: 10.1056/nejmc1409550.
Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary SyndromeLegro R, Brzyski R, Diamond M, Coutifaris C, Schlaff W, Casson P, Christman G, Huang H, Yan Q, Alvero R, Haisenleder D, Barnhart K, Bates G, Usadi R, Lucidi S, Baker V, Trussell J, Krawetz S, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole Versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2014, 69: 599-601. DOI: 10.1097/01.ogx.0000456355.64379.77.
DiscussionSong C, Zhang H. Discussion. International Statistical Review 2014, 82: 359-361. PMID: 25844011, PMCID: PMC4380222, DOI: 10.1111/insr.12060.
TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol AddictionSong C, Zhang H. TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction. Genetic Epidemiology 2014, 38: 552-559. PMID: 25041903, PMCID: PMC4154634, DOI: 10.1002/gepi.21843.
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary SyndromeLegro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 119-129. PMID: 25006718, PMCID: PMC4175743, DOI: 10.1056/nejmoa1313517.
Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s TauJiang Y, Li N, Zhang H. Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall’s Tau. Journal Of The American Statistical Association 2014, 109: 905-930. PMID: 25382885, PMCID: PMC4219655, DOI: 10.1080/01621459.2014.901223.
0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in ShanghaiBassig B, Friesen M, Vermeulen R, Shu X, Purdue M, Stewart P, Lu W, Xiang Y, Chow W, Zheng T, Ji B, Yang G, Linet M, Hu W, Zhang H, Zheng W, Gao Y, Rothman N, Lan Q. 0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai0324 Occupational exposure to benzene and risk of non-Hodgkin lymphoma in a population-based cohort study of Chinese women in Shanghai. Occupational And Environmental Medicine 2014, 71: a40. DOI: 10.1136/oemed-2014-102362.125.
Maternal serum serpin B7 is associated with early spontaneous preterm birthParry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA, Research E. Maternal serum serpin B7 is associated with early spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2014, 211: 678.e1-678.e12. PMID: 24954659, PMCID: PMC4254341, DOI: 10.1016/j.ajog.2014.06.035.
Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trialShi Y, Wei D, Liang X, Sun Y, Liu J, Cao Y, Zhang B, Legro RS, Zhang H, Chen ZJ. Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial. Trials 2014, 15: 154. PMID: 24885793, PMCID: PMC4022358, DOI: 10.1186/1745-6215-15-154.
Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm NeonatesShankaran S, Lin A, Maller-Kesselman J, Zhang H, O'Shea TM, Bada HS, Kaiser JR, Lifton RP, Bauer CR, Ment LR, Study G. Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates. The Journal Of Pediatrics 2014, 164: 1005-1011.e3. PMID: 24589078, PMCID: PMC4095864, DOI: 10.1016/j.jpeds.2014.01.036.
A novel staging model to classify oesophageal squamous cell carcinoma patients in ChinaTan H, Zhang H, Xie J, Chen B, Wen C, Guo X, Zhao Q, Wu Z, Shen J, Wu J, Xu X, Li E, Xu L, Wang X. A novel staging model to classify oesophageal squamous cell carcinoma patients in China. British Journal Of Cancer 2014, 110: 2109-2115. PMID: 24569468, PMCID: PMC3992487, DOI: 10.1038/bjc.2014.101.
Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependenceZuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X. Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics 2013, 23: 233-238. PMID: 23907288, PMCID: PMC3941913, DOI: 10.1097/ypg.0b013e328364b8c7.
Gene–environment interactions in severe intraventricular hemorrhage of preterm neonatesMent LR, Ådén U, Lin A, Kwon SH, Choi M, Hallman M, Lifton RP, Zhang H, Bauer CR. Gene–environment interactions in severe intraventricular hemorrhage of preterm neonates. Pediatric Research 2013, 75: 241-250. PMID: 24192699, PMCID: PMC3946468, DOI: 10.1038/pr.2013.195.
The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trialLegro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Alvero R, Casson P, Christman GM, Huang H, Yan Q, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi R, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H, Network I. The Pregnancy in Polycystic Ovary Syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial. Fertility And Sterility 2013, 101: 258-269.e8. PMID: 24156957, PMCID: PMC3899700, DOI: 10.1016/j.fertnstert.2013.08.056.
Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependenceZuo L, Wang K, Wang G, Pan X, Zhang X, Zhang H, Luo X. Common PTP4A1‐PHF3‐EYS variants are specific for alcohol dependence. American Journal On Addictions 2013, 23: 411-414. PMID: 24961364, PMCID: PMC4111256, DOI: 10.1111/j.1521-0391.2013.12115.x.
Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled TrialKuang H, Li Y, Wu X, Hou L, Wu T, Liu J, Ng EH, Stener-Victorin E, Legro RS, Zhang H. Acupuncture and Clomiphene Citrate for Live Birth in Polycystic Ovary Syndrome: Study Design of a Randomized Controlled Trial. Evidence-based Complementary And Alternative Medicine 2013, 2013: 527303. PMID: 24023577, PMCID: PMC3762180, DOI: 10.1155/2013/527303.
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descentZuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.
Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm NeonatesÅdén U, Lin A, Carlo W, Leviton A, Murray JC, Hallman M, Lifton RP, Zhang H, Ment LR, Group G. Candidate Gene Analysis: Severe Intraventricular Hemorrhage in Inborn Preterm Neonates. The Journal Of Pediatrics 2013, 163: 1503-1506.e1. PMID: 23896193, PMCID: PMC3812267, DOI: 10.1016/j.jpeds.2013.06.025.
Robust Variable Selection With Exponential Squared LossWang X, Jiang Y, Huang M, Zhang H. Robust Variable Selection With Exponential Squared Loss. Journal Of The American Statistical Association 2013, 108: 632-643. PMID: 23913996, PMCID: PMC3727454, DOI: 10.1080/01621459.2013.766613.
Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autismZuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X. Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics 2013, 132: 735-743. PMID: 23468174, PMCID: PMC3683370, DOI: 10.1007/s00439-013-1277-4.
NCK2 Is Significantly Associated with Opiates Addiction in African-Origin MenLiu Z, Guo X, Jiang Y, Zhang H. NCK2 Is Significantly Associated with Opiates Addiction in African-Origin Men. The Scientific World JOURNAL 2013, 2013: 748979. PMID: 23533358, PMCID: PMC3603435, DOI: 10.1155/2013/748979.
NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descentZuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1–SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug And Alcohol Dependence 2013, 129: 254-264. PMID: 23455491, PMCID: PMC3628730, DOI: 10.1016/j.drugalcdep.2013.02.006.
Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS)Wolff EF, He Y, Black DM, Brinton EA, Budoff MJ, Cedars MI, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Pal L, Santoro N, Zhang H, Harman SM, Taylor HS. Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estrogen prevention study (KEEPS). Fertility And Sterility 2013, 99: 1385-1391. PMID: 23312232, PMCID: PMC3615128, DOI: 10.1016/j.fertnstert.2012.11.053.
Statistical Inference of Biometrical Genetic Model With Cultural Transmission.Guo X, Ji T, Wang X, Zhang H, Zhong S. Statistical Inference of Biometrical Genetic Model With Cultural Transmission. Statistics And Its Interface 2013, 6: 91-98. PMID: 24660046, PMCID: PMC3959174, DOI: 10.4310/sii.2013.v6.n1.a9.
Multiple Change-Point Detection via a Screening and Ranking Algorithm.Hao N, Niu YS, Zhang H. Multiple Change-Point Detection via a Screening and Ranking Algorithm. Statistica Sinica 2013, 23: 1553-1572. PMID: 24489450, PMCID: PMC3902887, DOI: 10.5705/ss.2012.018s.
Large Scale Association Analysis for Drug Addiction: Results from SNP to GeneGuo X, Liu Z, Wang X, Zhang H. Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene. The Scientific World JOURNAL 2012, 2012: 939584. PMID: 23365539, PMCID: PMC3543790, DOI: 10.1100/2012/939584.
Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine CodependenceZuo L, Zhang X, Wang F, Li C, Lu L, Ye L, Zhang H, Krystal JH, Deng H, Luo X. Genome‐Wide Significant Association Signals in IPO11‐HTR1A Region Specific for Alcohol and Nicotine Codependence. Alcohol Clinical And Experimental Research 2012, 37: 730-739. PMID: 23216389, PMCID: PMC3610804, DOI: 10.1111/acer.12032.
Simulating Realistic Genomic Data With Rare VariantsXu Y, Wu Y, Song C, Zhang H. Simulating Realistic Genomic Data With Rare Variants. Genetic Epidemiology 2012, 37: 163-172. PMID: 23161487, PMCID: PMC3543480, DOI: 10.1002/gepi.21696.
A nonparametric regression method for multiple longitudinal phenotypes using multivariate adaptive splinesZhu W, Zhang H. A nonparametric regression method for multiple longitudinal phenotypes using multivariate adaptive splines. Frontiers Of Mathematics In China 2012, 8: 731-743. PMID: 25309585, PMCID: PMC4193387, DOI: 10.1007/s11464-012-0256-8.
Prenatal Exposure to Nicotine and Impaired Reading PerformanceCho K, Frijters JC, Zhang H, Miller LL, Gruen JR. Prenatal Exposure to Nicotine and Impaired Reading Performance. The Journal Of Pediatrics 2012, 162: 713-718.e2. PMID: 23122624, PMCID: PMC3577994, DOI: 10.1016/j.jpeds.2012.09.041.
Genetic Association Test for Multiple Traits at Gene LevelGuo X, Liu Z, Wang X, Zhang H. Genetic Association Test for Multiple Traits at Gene Level. Genetic Epidemiology 2012, 37: 122-129. PMID: 23032486, PMCID: PMC3524409, DOI: 10.1002/gepi.21688.
Rare ADH Variant Constellations are Specific for Alcohol DependenceZuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH Variant Constellations are Specific for Alcohol Dependence. Alcohol And Alcoholism 2012, 48: 9-14. PMID: 23019235, PMCID: PMC3523382, DOI: 10.1093/alcalc/ags104.
A left cerebellar pathway mediates language in prematurely-born young adultsConstable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.
Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary SyndromeDiamond M, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr B, McGovern P, Cataldo N, Steinkampf M, Gosman G, Nestler J, Carson S, Myers E, Eisenberg E, Legro R. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2012, 67: 548-549. DOI: 10.1097/01.ogx.0000421452.19985.8f.
THE SCREENING AND RANKING ALGORITHM TO DETECT DNA COPY NUMBER VARIATIONS.Niu YS, Zhang H. THE SCREENING AND RANKING ALGORITHM TO DETECT DNA COPY NUMBER VARIATIONS. The Annals Of Applied Statistics 2012, 6: 1306-1326. PMID: 24069112, PMCID: PMC3779928, DOI: 10.1214/12-aoas539supp.
Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary SyndromeRoth LW, Huang H, Legro RS, Diamond MP, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Zhang H, Schlaff WD. Altering Hirsutism Through Ovulation Induction in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 1151-1156. PMID: 22617579, PMCID: PMC3360417, DOI: 10.1097/aog.0b013e31825618fb.
Multiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying CovariatesSkup M, Zhu H, Zhang H. Multiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying Covariates. Biometrics 2012, 68: 1083-1092. PMID: 22551084, PMCID: PMC3767131, DOI: 10.1111/j.1541-0420.2012.01767.x.
Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary SyndromeDiamond MP, Kruger M, Santoro N, Zhang H, Casson P, Schlaff W, Coutifaris C, Brzyski R, Christman G, Carr BR, McGovern PG, Cataldo NA, Steinkampf MP, Gosman GG, Nestler JE, Carson S, Myers EE, Eisenberg E, Legro RS. Endometrial Shedding Effect on Conception and Live Birth in Women With Polycystic Ovary Syndrome. Obstetrics And Gynecology 2012, 119: 902-908. PMID: 22525900, PMCID: PMC4007263, DOI: 10.1097/aog.0b013e31824da35c.
Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependenceZuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, Lu L, Hong J, Lu L, Krystal J, Deng H, Luo X. Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 437-444. PMID: 22488850, PMCID: PMC3405545, DOI: 10.1002/ajmg.b.32047.
Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's TauZhu W, Jiang Y, Zhang H. Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau. Journal Of The American Statistical Association 2012, 107: 1-11. PMID: 22745516, PMCID: PMC3381868, DOI: 10.1080/01621459.2011.643707.
Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertilityHuang H, Hansen KR, Factor-Litvak P, Carson SA, Guzick DS, Santoro N, Diamond MP, Eisenberg E, Zhang H, Network I. Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility. Fertility And Sterility 2012, 97: 959-967.e5. PMID: 22270557, PMCID: PMC3319287, DOI: 10.1016/j.fertnstert.2012.01.090.
The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndromeLegro RS, Kunselman AR, Brzyski RG, Casson PR, Diamond MP, Schlaff WD, Christman GM, Coutifaris C, Taylor HS, Eisenberg E, Santoro N, Zhang H, Network F. The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial: Rationale and design of a double-blind randomized trial of clomiphene citrate and letrozole for the treatment of infertility in women with polycystic ovary syndrome. Contemporary Clinical Trials 2012, 33: 470-481. PMID: 22265923, PMCID: PMC3312939, DOI: 10.1016/j.cct.2011.12.005.
Recursive Partitioning and Tree-based MethodsZhang H. Recursive Partitioning and Tree-based Methods. 2011, 853-882. DOI: 10.1007/978-3-642-21551-3_29.
Recruitment challenges of a multicenter randomized controlled varicocelectomy trialTrussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H, Network R. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertility And Sterility 2011, 96: 1299-1305. PMID: 22130101, PMCID: PMC3243664, DOI: 10.1016/j.fertnstert.2011.10.025.
Novel tree-based method to generate markers from rare variant dataJiang Y, Brennan JS, Calixte R, He Y, Nyirabahizi E, Zhang H. Novel tree-based method to generate markers from rare variant data. BMC Proceedings 2011, 5: s102. PMID: 22373418, PMCID: PMC3287825, DOI: 10.1186/1753-6561-5-s9-s102.
A LASSO-based approach to analyzing rare variants in genetic association studiesBrennan JS, He Y, Calixte R, Nyirabahizi E, Jiang Y, Zhang H. A LASSO-based approach to analyzing rare variants in genetic association studies. BMC Proceedings 2011, 5: s100. PMID: 22373373, PMCID: PMC3287823, DOI: 10.1186/1753-6561-5-s9-s100.
A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association StudyZuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X. A Novel, Functional and Replicable Risk Gene Region for Alcohol Dependence Identified by Genome-Wide Association Study. PLOS ONE 2011, 6: e26726. PMID: 22096494, PMCID: PMC3210123, DOI: 10.1371/journal.pone.0026726.
Proactively Establishing a Biologic Specimens Repository for Large Clinical Trials: An Idea Whose Time has ComeCasson PR, Krawetz SA, Diamond MP, Zhang H, Legro RS, Schlaff WD, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Proactively Establishing a Biologic Specimens Repository for Large Clinical Trials: An Idea Whose Time has Come. Systems Biology In Reproductive Medicine 2011, 57: 217-221. PMID: 21951166, PMCID: PMC3848250, DOI: 10.3109/19396368.2011.604818.
Establishing a Biologic Specimens Repository for Reproductive Clinical Trials: Technical AspectsKrawetz SA, Casson PR, Diamond MP, Zhang H, Legro RS, Schlaff WD, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Establishing a Biologic Specimens Repository for Reproductive Clinical Trials: Technical Aspects. Systems Biology In Reproductive Medicine 2011, 57: 222-227. PMID: 21899384, PMCID: PMC3183133, DOI: 10.3109/19396368.2011.604819.
Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trialDiamond MP, Mitwally M, Casper R, Ager J, Legro RS, Brzyski R, Casson P, Eisenberg E, Zhang H, Network F. Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Contemporary Clinical Trials 2011, 32: 902-908. PMID: 21787883, PMCID: PMC3708642, DOI: 10.1016/j.cct.2011.07.009.
Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studiesSchlaff WD, Zhang H, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Barnhart KT, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Santoro N, Eisenberg E, Huang H, Legro RS, Network R. Increasing burden of institutional review in multicenter clinical trials of infertility: the Reproductive Medicine Network experience with the Pregnancy in Polycystic Ovary Syndrome (PPCOS) I and II studies. Fertility And Sterility 2011, 96: 15-18. PMID: 21645894, PMCID: PMC3151556, DOI: 10.1016/j.fertnstert.2011.05.069.
Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNISkup M, Zhu H, Wang Y, Giovanello KS, Lin JA, Shen D, Shi F, Gao W, Lin W, Fan Y, Zhang H, Initiative T. Sex differences in grey matter atrophy patterns among AD and aMCI patients: Results from ADNI. NeuroImage 2011, 56: 890-906. PMID: 21356315, PMCID: PMC3085726, DOI: 10.1016/j.neuroimage.2011.02.060.
Statistical Inference in Mixed Models and Analysis of Twin and Family DataWang X, Guo X, He M, Zhang H. Statistical Inference in Mixed Models and Analysis of Twin and Family Data. Biometrics 2011, 67: 987-995. PMID: 21306354, PMCID: PMC3129472, DOI: 10.1111/j.1541-0420.2010.01548.x.
The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin WomenChen X, Cho K, Singer BH, Zhang H. The Nuclear Transcription Factor PKNOX2 Is a Candidate Gene for Substance Dependence in European-Origin Women. PLOS ONE 2011, 6: e16002. PMID: 21298047, PMCID: PMC3029286, DOI: 10.1371/journal.pone.0016002.
Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorderJiang Y, Zhang H. Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder. Genetic Epidemiology 2011, 35: 125-132. PMID: 21254220, PMCID: PMC3077545, DOI: 10.1002/gepi.20558.
The use of classification trees for bioinformaticsChen X, Wang M, Zhang H. The use of classification trees for bioinformatics. Wiley Interdisciplinary Reviews Data Mining And Knowledge Discovery 2011, 1: 55-63. PMID: 22523608, PMCID: PMC3329156, DOI: 10.1002/widm.14.
Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini‐exome dataBailey‐Wilson J, Brennan JS, Bull SB, Culverhouse R, Kim Y, Jiang Y, Jung J, Li Q, Lamina C, Liu Y, Mägi R, Niu YS, Simpson CL, Wang L, Yilmaz YE, Zhang H, Zhang Z. Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini‐exome data. Genetic Epidemiology 2011, 35: s92-s100. PMID: 22128066, PMCID: PMC3360949, DOI: 10.1002/gepi.20657.
Statistical Analysis in Genetic Studies of Mental IllnessesZhang H. Statistical Analysis in Genetic Studies of Mental Illnesses. Statistical Science 2011, 26: 116-129. PMID: 21909187, PMCID: PMC3169093, DOI: 10.1214/11-sts353.
Impaired consciousness in temporal lobe seizures: role of cortical slow activityEnglot DJ, Yang L, Hamid H, Danielson N, Bai X, Marfeo A, Yu L, Gordon A, Purcaro MJ, Motelow JE, Agarwal R, Ellens DJ, Golomb JD, Shamy MC, Zhang H, Carlson C, Doyle W, Devinsky O, Vives K, Spencer DD, Spencer SS, Schevon C, Zaveri HP, Blumenfeld H. Impaired consciousness in temporal lobe seizures: role of cortical slow activity. Brain 2010, 133: 3764-3777. PMID: 21081551, PMCID: PMC2995886, DOI: 10.1093/brain/awq316.
The Impact of Environmental and Genetic Factors on Neonatal Late-Onset SepsisBizzarro MJ, Jiang Y, Hussain N, Gruen JR, Bhandari V, Zhang H. The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis. The Journal Of Pediatrics 2010, 158: 234-238.e1. PMID: 20850766, PMCID: PMC3008342, DOI: 10.1016/j.jpeds.2010.07.060.
Total Testosterone Assays in Women with Polycystic Ovary Syndrome: Precision and Correlation with HirsutismLegro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Santoro N, Eisenberg E, Zhang M, Zhang H. Total Testosterone Assays in Women with Polycystic Ovary Syndrome: Precision and Correlation with Hirsutism. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 5305-5313. PMID: 20826578, PMCID: PMC2999971, DOI: 10.1210/jc.2010-1123.
Ovulation induction with clomiphene, metformin, or a combination of the two does not affect hirsutism score over a standard course of treatment in women with polycystic ovary syndromeSchlaff W, Legro R, Diamond M, Coutifaris C, Zhang H, Network R. Ovulation induction with clomiphene, metformin, or a combination of the two does not affect hirsutism score over a standard course of treatment in women with polycystic ovary syndrome. Fertility And Sterility 2010, 94: s192-s193. DOI: 10.1016/j.fertnstert.2010.07.749.
Impact of the institutional research review process on initiating a clinical study: the reproductive medicine network (RMN) experience with pregnancy in polycystic ovary syndrome I and IISchlaff W, Legro R, Diamond M, Coutifaris C, Zhang H, Network R. Impact of the institutional research review process on initiating a clinical study: the reproductive medicine network (RMN) experience with pregnancy in polycystic ovary syndrome I and II. Fertility And Sterility 2010, 94: s196-s197. DOI: 10.1016/j.fertnstert.2010.07.763.
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndromeZhang H, Legro RS, Zhang J, Zhang L, Chen X, Huang H, Casson PR, Schlaff WD, Diamond MP, Krawetz SA, Coutifaris C, Brzyski RG, Christman GM, Santoro N, Eisenberg E. Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. Human Reproduction 2010, 25: 2612-2621. PMID: 20716558, PMCID: PMC2939757, DOI: 10.1093/humrep/deq210.
An Association Test for Multiple Traits Based on the Generalized Kendall’s TauZhang H, Liu CT, Wang X. An Association Test for Multiple Traits Based on the Generalized Kendall’s Tau. Journal Of The American Statistical Association 2010, 105: 473-481. PMID: 20711441, PMCID: PMC2920220, DOI: 10.1198/jasa.2009.ap08387.
Maximal conditional chi-square importance in random forestsWang M, Chen X, Zhang H. Maximal conditional chi-square importance in random forests. Bioinformatics 2010, 26: 831-837. PMID: 20130032, PMCID: PMC2832825, DOI: 10.1093/bioinformatics/btq038.
Recursive Partitioning and ApplicationsZhang H, Singer B. Recursive Partitioning and Applications. 2010, 0 DOI: 10.1007/978-1-4419-6824-1.
Memory management in genome-wide association studiesChen X, Zhang M, Wang M, Zhu W, Cho K, Zhang H. Memory management in genome-wide association studies. BMC Proceedings 2009, 3: s54. PMID: 20018047, PMCID: PMC2795954, DOI: 10.1186/1753-6561-3-s7-s54.
Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forestsWang M, Chen X, Zhang M, Zhu W, Cho K, Zhang H. Detecting significant single-nucleotide polymorphisms in a rheumatoid arthritis study using random forests. BMC Proceedings 2009, 3: s69. PMID: 20018063, PMCID: PMC2795970, DOI: 10.1186/1753-6561-3-s7-s69.
A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splinesZhu W, Cho K, Chen X, Zhang M, Wang M, Zhang H. A genome-wide association analysis of Framingham Heart Study longitudinal data using multivariate adaptive splines. BMC Proceedings 2009, 3: s119. PMID: 20017984, PMCID: PMC2795891, DOI: 10.1186/1753-6561-3-s7-s119.
The Genetic Susceptibility to Respiratory Distress SyndromeLevit O, Jiang Y, Bizzarro MJ, Hussain N, Buhimschi CS, Gruen JR, Zhang H, Bhandari V. The Genetic Susceptibility to Respiratory Distress Syndrome. Pediatric Research 2009, 66: 693-697. PMID: 19687775, PMCID: PMC2796284, DOI: 10.1203/pdr.0b013e3181bbce86.
Detecting Genes and Gene–Gene Interactions for Age-Related Macular Degeneration with a Forest-based ApproachWang M, Zhang M, Chen X, Zhang H. Detecting Genes and Gene–Gene Interactions for Age-Related Macular Degeneration with a Forest-based Approach. Statistics In Biopharmaceutical Research 2009, 1: 424-430. PMID: 20161521, PMCID: PMC2799940, DOI: 10.1198/sbr.2009.0046.
Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive DisorderLin H, Williams KA, Katsovich L, Findley DB, Grantz H, Lombroso PJ, King RA, Bessen DE, Johnson D, Kaplan EL, Landeros-Weisenberger A, Zhang H, Leckman JF. Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder. Biological Psychiatry 2009, 67: 684-691. PMID: 19833320, PMCID: PMC2843763, DOI: 10.1016/j.biopsych.2009.08.020.
The Null Distributions of Test Statistics in Genomewide Association StudiesChen X, Zhang H. The Null Distributions of Test Statistics in Genomewide Association Studies. Statistics In Biosciences 2009, 1: 214-227. PMID: 20190869, PMCID: PMC2826849, DOI: 10.1007/s12561-009-9011-4.
Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIVGhebremichael M, Paintsil E, Ickovics JR, Vlahov D, Schuman P, Boland R, Schoenbaum E, Moore J, Zhang H. Longitudinal association of alcohol use with HIV disease progression and psychological health of women with HIV. AIDS Care 2009, 21: 834-841. PMID: 20024739, PMCID: PMC3292857, DOI: 10.1080/09540120802537864.
Analysis of Twin Data Using SASFeng R, Zhou G, Zhang M, Zhang H. Analysis of Twin Data Using SAS. Biometrics 2009, 65: 584-589. PMID: 18647295, PMCID: PMC2700843, DOI: 10.1111/j.1541-0420.2008.01098.x.
Willows: a memory efficient tree and forest construction packageZhang H, Wang M, Chen X. Willows: a memory efficient tree and forest construction package. BMC Bioinformatics 2009, 10: 130. PMID: 19416535, PMCID: PMC2683818, DOI: 10.1186/1471-2105-10-130.
The familial aggregation of cannabis use disordersMerikangas KR, Li JJ, Stipelman B, Yu K, Fucito L, Swendsen J, Zhang H. The familial aggregation of cannabis use disorders. Addiction 2009, 104: 622-629. PMID: 19335660, PMCID: PMC2794246, DOI: 10.1111/j.1360-0443.2008.02468.x.
Why do we test multiple traits in genetic association studies?Zhu W, Zhang H. Why do we test multiple traits in genetic association studies? Journal Of The Korean Statistical Society 2009, 38: 1-10. PMID: 19655045, PMCID: PMC2719985, DOI: 10.1016/j.jkss.2008.10.006.
Rejoinder: Why do we test multiple traits in genetic association studies?Zhu W, Zhang H. Rejoinder: Why do we test multiple traits in genetic association studies? Journal Of The Korean Statistical Society 2009, 38: 25-27. PMID: 19644568, PMCID: PMC2717730, DOI: 10.1016/j.jkss.2008.10.007.
Genetic Contribution to Patent Ductus Arteriosus in the Premature NewbornBhandari V, Zhou G, Bizzarro MJ, Buhimschi C, Hussain N, Gruen JR, Zhang H. Genetic Contribution to Patent Ductus Arteriosus in the Premature Newborn. Pediatrics 2009, 123: 669-673. PMID: 19171636, PMCID: PMC3161726, DOI: 10.1542/peds.2008-1117.
Search for the smallest random forest.Wang M, Zhang H. Search for the smallest random forest. Statistics And Its Interface 2009, 2: 381. PMID: 20165560, PMCID: PMC2822360, DOI: 10.4310/sii.2009.v2.n3.a11.
Machine learning in genome‐wide association studiesSzymczak S, Biernacka JM, Cordell HJ, González‐Recio O, König IR, Zhang H, Sun YV. Machine learning in genome‐wide association studies. Genetic Epidemiology 2009, 33: s51-s57. PMID: 19924717, DOI: 10.1002/gepi.20473.
Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium.Sun R, Peng S, Chen X, Zhang H, Rizzolo LJ. Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium. Molecular Vision 2008, 14: 2237-62. PMID: 19057659, PMCID: PMC2593753.
LOT: a tool for linkage analysis of ordinal traits for pedigree dataZhang M, Feng R, Chen X, Hu B, Zhang H. LOT: a tool for linkage analysis of ordinal traits for pedigree data. Bioinformatics 2008, 24: 1737-1739. PMID: 18535081, PMCID: PMC2566542, DOI: 10.1093/bioinformatics/btn258.
A tree-based method for modeling a multivariate ordinal responseYe Y, Zhang H. A tree-based method for modeling a multivariate ordinal response. Statistics And Its Interface 2008, 1: 169-178. PMID: 18852827, PMCID: PMC2566541, DOI: 10.4310/sii.2008.v1.n1.a14.
Modelling gene regulation networks via multivariate adaptive splines.Chen X, Zhang H. Modelling gene regulation networks via multivariate adaptive splines. Cancer Genomics & Proteomics 2008, 5: 55-62. PMID: 18359980, PMCID: PMC3159687.
A forest-based approach to identifying gene and gene–gene interactionsChen X, Liu CT, Zhang M, Zhang H. A forest-based approach to identifying gene and gene–gene interactions. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19199-19203. PMID: 18048322, PMCID: PMC2148267, DOI: 10.1073/pnas.0709868104.
Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic toolsZhu Y, Hoffman A, Wu X, Zhang H, Zhang Y, Leaderer D, Zheng T. Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2007, 639: 80-88. PMID: 18191955, PMCID: PMC2292456, DOI: 10.1016/j.mrfmmm.2007.11.005.
A genomic imprinting test for ordinal traits in pedigree dataFeng R, Zhang H. A genomic imprinting test for ordinal traits in pedigree data. Genetic Epidemiology 2007, 32: 132-142. PMID: 17922481, DOI: 10.1002/gepi.20270.
Ascertainment in Genetics StudiesWang X, Zhang H. Ascertainment in Genetics Studies. 2007 DOI: 10.1002/9780470015902.a0005435.
Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier.Rizzolo LJ, Chen X, Weitzman M, Sun R, Zhang H. Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Molecular Vision 2007, 13: 1259-73. PMID: 17679949.
A score test for linkage analysis of ordinal traits based on IBD sharingFeng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based studyXu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, Britton J, Neugut A, Santella R, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28: 1504-1509. PMID: 17372271, DOI: 10.1093/carcin/bgm061.
Guideline for data analysis of genomewide association studies.Zhang H, Liu L, Wang X, Gruen JR. Guideline for data analysis of genomewide association studies. Cancer Genomics & Proteomics 2007, 4: 27-34. PMID: 17726238.
DOPA decarboxylase gene is associated with nicotine dependenceZhang H, Ye Y, Wang X, Gelernter J, Z J, Li MD. DOPA decarboxylase gene is associated with nicotine dependence. Pharmacogenomics 2006, 7: 1159-1166. PMID: 17184203, DOI: 10.2217/14622416.7.8.1159.
Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorderLin H, Katsovich L, Ghebremichael M, Findley DB, Grantz H, Lombroso PJ, King RA, Zhang H, Leckman JF. Psychosocial stress predicts future symptom severities in children and adolescents with Tourette syndrome and/or obsessive‐compulsive disorder. Journal Of Child Psychology And Psychiatry 2006, 48: 157-166. PMID: 17300554, PMCID: PMC3073143, DOI: 10.1111/j.1469-7610.2006.01687.x.
Family‐based association tests for ordinal traits adjusting for covariatesWang X, Ye Y, Zhang H. Family‐based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology 2006, 30: 728-736. PMID: 17086513, DOI: 10.1002/gepi.20184.
Genetic Susceptibility to Retinopathy of PrematurityBizzarro MJ, Hussain N, Jonsson B, Feng R, Ment LR, Gruen JR, Zhang H, Bhandari V. Genetic Susceptibility to Retinopathy of Prematurity. Pediatrics 2006, 118: 1858-1863. PMID: 17079555, DOI: 10.1542/peds.2006-1088.
The Dose Effect of a Group Intervention for Bereaved HIV-Positive IndividualsGhebremichael M, Hansen N, Zhang H, Sikkema K. The Dose Effect of a Group Intervention for Bereaved HIV-Positive Individuals. Group Dynamics Theory Research And Practice 2006, 10: 167-180. DOI: 10.1037/1089-2699.10.3.167.
A Randomized Controlled Trial of a Coping Group Intervention for Adults With HIV Who Are AIDS Bereaved: Longitudinal Effects on GriefSikkema KJ, Hansen NB, Ghebremichael M, Kochman A, Tarakeshwar N, Meade CS, Zhang H. A Randomized Controlled Trial of a Coping Group Intervention for Adults With HIV Who Are AIDS Bereaved: Longitudinal Effects on Grief. Health Psychology 2006, 25: 563-570. PMID: 17014273, DOI: 10.1037/0278-6133.25.5.563.
Longitudinal Effects of Coping on Outcome in a Randomized Controlled Trial of a Group Intervention for HIV-Positive Adults with AIDS-Related BereavementHansen NB, Tarakeshwar N, Ghebremichael M, Zhang H, Kochman A, Sikkema KJ. Longitudinal Effects of Coping on Outcome in a Randomized Controlled Trial of a Group Intervention for HIV-Positive Adults with AIDS-Related Bereavement. Death Studies 2006, 30: 609-636. PMID: 16865824, DOI: 10.1080/07481180600776002.
Linkage analysis of longitudinal data and design considerationZhang H, Zhong X. Linkage analysis of longitudinal data and design consideration. BMC Genomic Data 2006, 7: 37. PMID: 16768806, PMCID: PMC1550417, DOI: 10.1186/1471-2156-7-37.
Familial and Genetic Susceptibility to Major Neonatal Morbidities in Preterm TwinsBhandari V, Bizzarro MJ, Shetty A, Zhong X, Page GP, Zhang H, Ment LR, Gruen JR. Familial and Genetic Susceptibility to Major Neonatal Morbidities in Preterm Twins. Pediatrics 2006, 117: 1901-1906. PMID: 16740829, DOI: 10.1542/peds.2005-1414.
Cortical neurogenesis enhanced by chronic perinatal hypoxiaFagel DM, Ganat Y, Silbereis J, Ebbitt T, Stewart W, Zhang H, Ment LR, Vaccarino FM. Cortical neurogenesis enhanced by chronic perinatal hypoxia. Experimental Neurology 2006, 199: 77-91. PMID: 15916762, DOI: 10.1016/j.expneurol.2005.04.006.
Substance-abusing mothers and disruptions in child custody: An attachment perspectiveSuchman NE, McMahon TJ, Zhang H, Mayes LC, Luthar S. Substance-abusing mothers and disruptions in child custody: An attachment perspective. Journal Of Substance Use And Addiction Treatment 2006, 30: 197-204. PMID: 16616163, PMCID: PMC1850760, DOI: 10.1016/j.jsat.2005.11.008.
A statistical framework for the classification of tensor morphologies in diffusion tensor imagesZhu H, Xu D, Raz A, Hao X, Zhang H, Kangarlu A, Bansal R, Peterson BS. A statistical framework for the classification of tensor morphologies in diffusion tensor images. Magnetic Resonance Imaging 2006, 24: 569-582. PMID: 16735178, PMCID: PMC2367261, DOI: 10.1016/j.mri.2006.01.004.
Ascertainment adjustment in genetic studies of ordinal traitsFeng R, Zhang H. Ascertainment adjustment in genetic studies of ordinal traits. Human Genetics 2006, 119: 429-435. PMID: 16528520, DOI: 10.1007/s00439-006-0147-8.
Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgerySedrakyan A, Zhang H, Treasure T, Krumholz HM. Recursive partitioning–based preoperative risk stratification for atrial fibrillation after coronary artery bypass surgery. American Heart Journal 2006, 151: 720-724. PMID: 16504639, DOI: 10.1016/j.ahj.2005.05.010.
Statistical Methodologies for Analyzing Genomic DataDuan F, Zhang H. Statistical Methodologies for Analyzing Genomic Data. 2006, 607-621. DOI: 10.1007/978-1-84628-288-1_33.
Asymptotics for estimation and testing procedures under loss of identifiabilityZhu H, Zhang H. Asymptotics for estimation and testing procedures under loss of identifiability. Journal Of Multivariate Analysis 2006, 97: 19-45. DOI: 10.1016/j.jmva.2004.11.005.
Generalized Score Test of Homogeneity for Mixed Effects ModelsZhang, H.P. and Zhu, H.T. Generalized Score Test of Homogeneity for Mixed Effects Models. Annals of Statistics 34: 1545-1569, 2006.
Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association StudiesZhang H, Wang X, Ye Y. Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies. Genetics 2006, 172: 693-699. PMID: 16219774, PMCID: PMC1456175, DOI: 10.1534/genetics.105.049122.
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette SyndromeBloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.
Associations of ethnicity/race and socioeconomic status with early childhood caries patterns.Psoter WJ, Pendrys DG, Morse DE, Zhang H, Mayne ST. Associations of ethnicity/race and socioeconomic status with early childhood caries patterns. Journal Of Public Health Dentistry 2006, 66: 23-9. PMID: 16570747, DOI: 10.1111/j.1752-7325.2006.tb02547.x.
Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism dataZhong X, Zhang H. Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data. BMC Genomic Data 2005, 6: s31. PMID: 16451641, PMCID: PMC1866754, DOI: 10.1186/1471-2156-6-s1-s31.
Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism dataZhang H, Zhong X, Ye Y. Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data. BMC Genomic Data 2005, 6: s118. PMID: 16451575, PMCID: PMC1866820, DOI: 10.1186/1471-2156-6-s1-s118.
A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smokingYe Y, Zhong X, Zhang H. A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking. BMC Genomic Data 2005, 6: s135. PMID: 16451594, PMCID: PMC1866801, DOI: 10.1186/1471-2156-6-s1-s135.
Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scansBailey-Wilson JE, Almasy L, de Andrade M, Bailey J, Bickeböller H, Cordell HJ, Daw EW, Goldin L, Goode EL, Gray-McGuire C, Hening W, Jarvik G, Maher BS, Mendell N, Paterson AD, Rice J, Satten G, Suarez B, Vieland V, Wilcox M, Zhang H, Ziegler A, MacCluer JW. Genetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans. BMC Genomic Data 2005, 6: s1. PMID: 16451554, PMCID: PMC1866841, DOI: 10.1186/1471-2156-6-s1-s1.
Comparison of survival times in a transplant study of hematologic disordersFu P, Laughlin MJ, Zhang H. Comparison of survival times in a transplant study of hematologic disorders. Contemporary Clinical Trials 2005, 27: 174-182. PMID: 16326144, DOI: 10.1016/j.cct.2005.10.003.
Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS)McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ, Spencer SS, Zubal IG, Blumenfeld H. Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS). Epilepsia 2005, 46: 1450-1464. PMID: 16146441, DOI: 10.1111/j.1528-1167.2005.06705.x.
Socioeconomic status and diagnosed diabetes incidenceRobbins JM, Vaccarino V, Zhang H, Kasl SV. Socioeconomic status and diagnosed diabetes incidence. Diabetes Research And Clinical Practice 2005, 68: 230-236. PMID: 15936465, DOI: 10.1016/j.diabres.2004.09.007.
Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndromeLeckman JF, Katsovich L, Kawikova I, Lin H, Zhang H, Krönig H, Morshed S, Parveen S, Grantz H, Lombroso PJ, King RA. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biological Psychiatry 2005, 57: 667-673. PMID: 15780855, DOI: 10.1016/j.biopsych.2004.12.004.
Tree-Based Cancer Classification and Diagnosis Using Gene Expression DataZhang H. Tree-Based Cancer Classification and Diagnosis Using Gene Expression Data. 2005, 43-51. DOI: 10.1385/1-59259-893-5:43.
Data miningCupples LA, Bailey J, Cartier KC, Falk CT, Liu K, Ye Y, Yu R, Zhang H, Zhao H. Data mining. Genetic Epidemiology 2005, 29: s103-s109. PMID: 16342179, DOI: 10.1002/gepi.20117.
Comparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3Wilcox MA, Pugh EW, Zhang H, Zhong X, Levinson DF, Kennedy GC, Wijsman EM. Comparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3. Genetic Epidemiology 2005, 29: s7-s28. PMID: 16342186, DOI: 10.1002/gepi.20106.
Preoperative Anxiety and Emergence Delirium and Postoperative Maladaptive BehaviorsKain ZN, Caldwell-Andrews AA, Maranets I, McClain B, Gaal D, Mayes LC, Feng R, Zhang H. Preoperative Anxiety and Emergence Delirium and Postoperative Maladaptive Behaviors. Anesthesia & Analgesia 2004, 99: 1648-1654. PMID: 15562048, DOI: 10.1213/01.ane.0000136471.36680.97.
Linkage analysis of ordinal traits for pedigree dataFeng R, Leckman JF, Zhang H. Linkage analysis of ordinal traits for pedigree data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 16739-16744. PMID: 15548606, PMCID: PMC534720, DOI: 10.1073/pnas.0404623101.
A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case StudiesCarriero N, Osier MV, Cheung KH, Miller PL, Gerstein M, Zhao H, Wu B, Rifkin S, Chang J, Zhang H, White K, Williams K, Schultz M. A High Productivity/Low Maintenance Approach to High-performance Computation for Biomedicine: Four Case Studies. Journal Of The American Medical Informatics Association 2004, 12: 90-98. PMID: 15492032, PMCID: PMC543832, DOI: 10.1197/jamia.m1571.
Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurityWeiss J, Takizawa B, McGee A, Stewart WB, Zhang H, Ment L, Schwartz M, Strittmatter S. Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity. Experimental Neurology 2004, 189: 141-149. PMID: 15296844, DOI: 10.1016/j.expneurol.2004.05.018.
Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weightsDuan F, Zhang H. Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights. Bioinformatics 2004, 20: 1766-1771. PMID: 15166015, DOI: 10.1093/bioinformatics/bth169.
Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smokingGelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.
EditorialHolford TR, Zhang H. Editorial. Statistical Methods In Medical Research 2004, 13: 1-1. PMID: 14746437, DOI: 10.1191/0962280204sm356ed.
Mixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve dataZhang H. Mixed effects multivariate adaptive splines model for the analysis of longitudinal and growth curve data. Statistical Methods In Medical Research 2004, 13: 63-82. PMID: 14746441, DOI: 10.1191/0962280204sm353ra.
Hypothesis testing in mixture regression modelsZhu H, Zhang H. Hypothesis testing in mixture regression models. Journal Of The Royal Statistical Society Series B (Statistical Methodology) 2003, 66: 3-16. DOI: 10.1046/j.1369-7412.2003.05379.x.
TREE-BASED METHODSZHANG H. TREE-BASED METHODS. 2003, 1033-1049. DOI: 10.1142/9789812388759_0027.
Recurrence of bipolar disorders and major depressionAngst J, Gamma A, Sellaro R, Lavori PW, Zhang H. Recurrence of bipolar disorders and major depression. European Archives Of Psychiatry And Clinical Neuroscience 2003, 253: 236-240. PMID: 14504992, DOI: 10.1007/s00406-003-0437-2.
Developmental Trajectories of Cocaine-and-Other-Drug—Exposed and Non-Cocaine—Exposed ChildrenMAYES LC, CICCHETTI D, ACHARYYA S, ZHANG H. Developmental Trajectories of Cocaine-and-Other-Drug—Exposed and Non-Cocaine—Exposed Children. Journal Of Developmental And Behavioral Pediatrics 2003, 24: 323-335. PMID: 14578693, DOI: 10.1097/00004703-200310000-00003.
Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort StudyMerikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J. Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study. JAMA Psychiatry 2003, 60: 993-1000. PMID: 14557144, DOI: 10.1001/archpsyc.60.9.993.
Tree‐based disease classification using protein dataZhu H, Yu C, Zhang H. Tree‐based disease classification using protein data. Proteomics 2003, 3: 1673-1677. PMID: 12973723, DOI: 10.1002/pmic.200300520.
STRUCTURE MIXTURE REGRESSION MODELSZHU H, ZHANG H. STRUCTURE MIXTURE REGRESSION MODELS. 2003, 272-287. DOI: 10.1142/9789812796707_0021.
Classification of dental caries patterns in the primary dentition: a multidimensional scaling analysis.Psoter WJ, Zhang H, Pendrys DG, Morse DE, Mayne ST. Classification of dental caries patterns in the primary dentition: a multidimensional scaling analysis. Community Dentistry And Oral Epidemiology 2003, 31: 231-8. PMID: 12752550, DOI: 10.1034/j.1600-0528.2003.00044.x.
Median ages of eruption of the primary teeth in white and Hispanic children from Arizona.Psoter WJ, Morse DE, Pendrys DG, Zhang H, Mayne ST. Median ages of eruption of the primary teeth in white and Hispanic children from Arizona. Pediatric Dentistry 2003, 25: 257-61. PMID: 12889703.
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive DisorderFINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.
Basal Ganglia Volumes in Patients With Gilles de la Tourette SyndromePeterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.
Cell and tumor classification using gene expression data: Construction of forestsZhang H, Yu CY, Singer B. Cell and tumor classification using gene expression data: Construction of forests. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 4168-4172. PMID: 12642676, PMCID: PMC153066, DOI: 10.1073/pnas.0230559100.
Mixed-Effects Multivariate Adaptive Splines ModelsZhang H. Mixed-Effects Multivariate Adaptive Splines Models. 2003, 171: 297-306. DOI: 10.1007/978-0-387-21579-2_18.
Assessing Sex Differences on Treatment Effectiveness from the Drug Abuse Treatment Outcome Study (DATOS)Acharyya S, Zhang H. Assessing Sex Differences on Treatment Effectiveness from the Drug Abuse Treatment Outcome Study (DATOS). The American Journal Of Drug And Alcohol Abuse 2003, 29: 415-444. PMID: 12765214, DOI: 10.1081/ada-120020524.
Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional ImpairmentSUKHODOLSKY DG, SCAHILL L, ZHANG H, PETERSON BS, KING RA, LOMBROSO PJ, KATSOVICH L, FINDLEY D, LECKMAN JF. Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 98-105. PMID: 12500082, DOI: 10.1097/00004583-200301000-00016.
Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndromeLeckman JF, Pauls DL, Zhang H, Rosario‐Campos M, Katsovich L, Kidd KK, Pakstis AJ, Alsobrook JP, Robertson MM, McMahon WM, Walkup JT, van de Wetering BJ, King RA, Cohen DJ. Obsessive‐compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2002, 116B: 60-68. PMID: 12497616, DOI: 10.1002/ajmg.b.10001.
A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born ChildrenPeterson BS, Vohr B, Kane MJ, Whalen DH, Schneider KC, Katz KH, Zhang H, Duncan CC, Makuch R, Gore JC, Ment LR. A Functional Magnetic Resonance Imaging Study of Language Processing and Its Cognitive Correlates in Prematurely Born Children. Pediatrics 2002, 110: 1153-1162. PMID: 12456913, DOI: 10.1542/peds.110.6.1153.
Disrupted synaptic development in the hypoxic newborn brainCurristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Disrupted synaptic development in the hypoxic newborn brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15729-15734. PMID: 12438650, PMCID: PMC137784, DOI: 10.1073/pnas.232568799.
Toward validation of atypical depression in the community: results of the Zurich cohort studyAngst J, Gamma A, Sellaro R, Zhang H, Merikangas K. Toward validation of atypical depression in the community: results of the Zurich cohort study. Journal Of Affective Disorders 2002, 72: 125-138. PMID: 12200203, DOI: 10.1016/s0165-0327(02)00169-6.
Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette SyndromeZhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR, Genetics T. Genomewide Scan of Hoarding in Sib Pairs in Which Both Sibs Have Gilles de la Tourette Syndrome. American Journal Of Human Genetics 2002, 70: 896-904. PMID: 11840360, PMCID: PMC379118, DOI: 10.1086/339520.
Tree-based analysis of microarray data for classifying breast cancer.Zhang H, Yu CY. Tree-based analysis of microarray data for classifying breast cancer. Frontiers In Bioscience-Landmark 2002, 7: c63-7. PMID: 11991861, DOI: 10.2741/a759.
The spectrum of social phobia in the zurich cohort study of young adultsMerikangas KR, Avenevoli S, Acharyya S, Zhang H, Angst J. The spectrum of social phobia in the zurich cohort study of young adults. Biological Psychiatry 2002, 51: 81-91. PMID: 11801233, DOI: 10.1016/s0006-3223(01)01309-9.
Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disordersMorshed S, Parveen S, Leckman J, Mercadante M, Kiss M, Miguel E, Arman A, Yazgan Y, Fujii T, Paul S, Peterson B, Zhang H, King R, Scahill L, Lombroso P. Antibodies against neural, nuclear, cytoskeletal, and streptococcal epitopes in children and adults with Tourette’s syndrome, Sydenham’s chorea, and autoimmune disorders. Biological Psychiatry 2001, 50: 566-577. PMID: 11690591, DOI: 10.1016/s0006-3223(01)01096-4.
Recursive partitioning for tumor classification with gene expression microarray dataZhang H, Yu C, Singer B, Xiong M. Recursive partitioning for tumor classification with gene expression microarray data. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6730-6735. PMID: 11381113, PMCID: PMC34421, DOI: 10.1073/pnas.111153698.
Thermal Sensitivity in Tourette Syndrome: Preliminary ReportScahill L, Lombroso P, Mack G, Van Wattum P, Zhang H, Vitale A, Leckman J. Thermal Sensitivity in Tourette Syndrome: Preliminary Report. Perceptual And Motor Skills 2001, 92: 419-432. PMID: 11361302, DOI: 10.2466/pms.2001.92.2.419.
Symptom dimensions in obsessive‐compulsive disorder: Toward quantitative phenotypesLeckman J, Zhang H, Alsobrook J, Pauls D. Symptom dimensions in obsessive‐compulsive disorder: Toward quantitative phenotypes. American Journal Of Medical Genetics 2001, 105: 28-30. PMID: 11424988, DOI: 10.1002/1096-8628(20010108)105:1<28::aid-ajmg1050>3.0.co;2-8.
Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination SurveyRobbins JM, Vaccarino V, Zhang H, Kasl SV. Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. American Journal Of Public Health 2001, 91: 76-83. PMID: 11189829, PMCID: PMC1446485, DOI: 10.2105/ajph.91.1.76.
Tree‐Based Linkage and Association Analyses of AsthmaZhang H, Tsai C, Yu C, Bonney G. Tree‐Based Linkage and Association Analyses of Asthma. Genetic Epidemiology 2001, 21: s317-s322. PMID: 11793691, DOI: 10.1002/gepi.2001.21.s1.s317.
Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Childrenvon Maffei J, Beckett W, Belanger K, Triche E, Zhang H, Machung J, Leaderer B. Risk Factors for Asthma Prevalence Among Urban and Nonurban African American Children. Journal Of Asthma 2001, 38: 555-564. PMID: 11714078, DOI: 10.1081/jas-100107120.
Use of classification trees for association studiesZhang H, Bonney G. Use of classification trees for association studies. Genetic Epidemiology 2000, 19: 323-332. PMID: 11108642, DOI: 10.1002/1098-2272(200012)19:4<323::aid-gepi4>3.0.co;2-5.
Excess type 2 diabetes in African-American women and men aged 40–74 and socioeconomic status: evidence from the Third National Health and Nutrition Examination SurveyRobbins JM, Vaccarino V, Zhang H, Kasl SV. Excess type 2 diabetes in African-American women and men aged 40–74 and socioeconomic status: evidence from the Third National Health and Nutrition Examination Survey. Journal Of Epidemiology & Community Health 2000, 54: 839. PMID: 11027198, PMCID: PMC1731578, DOI: 10.1136/jech.54.11.839.
A Frailty Model of Segregation Analysis: Understanding the Familial Transmission of AlcoholismZhang H, Merikangas K. A Frailty Model of Segregation Analysis: Understanding the Familial Transmission of Alcoholism. Biometrics 2000, 56: 815-823. PMID: 10985221, DOI: 10.1111/j.0006-341x.2000.00815.x.
Model for the Analysis of Binary Time Series of Respiratory SymptomsZhang H, Triche E, Leaderer B. Model for the Analysis of Binary Time Series of Respiratory Symptoms. American Journal Of Epidemiology 2000, 151: 1206-1215. PMID: 10905533, DOI: 10.1093/oxfordjournals.aje.a010171.
Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity DisordersPeterson BS, Leckman JF, Tucker D, Scahill L, Staib L, Zhang H, King R, Cohen DJ, Gore JC, Lombroso P. Preliminary Findings of Antistreptococcal Antibody Titers and Basal Ganglia Volumes in Tic, Obsessive-compulsive, and Attention-Deficit/Hyperactivity Disorders. JAMA Psychiatry 2000, 57: 364-372. PMID: 10768698, DOI: 10.1001/archpsyc.57.4.364.
Binary Regression for Risks in Excess of Subject-Specific ThresholdsZhang H, Zelterman D. Binary Regression for Risks in Excess of Subject-Specific Thresholds. Biometrics 1999, 55: 1247-1251. PMID: 11315077, DOI: 10.1111/j.0006-341x.1999.01247.x.
Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age ChildrenSCAHILL L, SCHWAB-STONE M, MERIKANGAS K, LECKMAN J, ZHANG H, KASL S. Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 976-984. PMID: 10434489, DOI: 10.1097/00004583-199908000-00013.
Analysis of Infant Growth Curves Using Multivariate Adaptive SplinesZhang H. Analysis of Infant Growth Curves Using Multivariate Adaptive Splines. Biometrics 1999, 55: 452-459. PMID: 11318199, DOI: 10.1111/j.0006-341x.1999.00452.x.
An fMRI study of stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systemsPeterson B, Skudlarski P, Gatenby J, Zhang H, Anderson A, Gore J. An fMRI study of stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biological Psychiatry 1999, 45: 1237-1258. PMID: 10349031, DOI: 10.1016/s0006-3223(99)00056-6.
Course of Tic Severity in Tourette Syndrome: The First Two DecadesLeckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 492. DOI: 10.1097/00004583-199904000-00029.
Recursive Partitioning in the Health SciencesZhang H, Singer B. Recursive Partitioning in the Health Sciences. 1999 DOI: 10.1007/978-1-4757-3027-2.
Familial Transmission of Substance Use DisordersMerikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, Zhang H, O'Malley SS, Rounsaville BJ. Familial Transmission of Substance Use Disorders. JAMA Psychiatry 1998, 55: 973-979. PMID: 9819065, DOI: 10.1001/archpsyc.55.11.973.
CommentZhang H. Comment. Journal Of The American Statistical Association 1998, 93: 948-950. DOI: 10.1080/01621459.1998.10473751.
A Double-Blind, Placebo-Controlled, Crossover Trial of an Antiandrogen in the Treatment of Tourette's SyndromePeterson B, Zhang H, Anderson G, Leckman J. A Double-Blind, Placebo-Controlled, Crossover Trial of an Antiandrogen in the Treatment of Tourette's Syndrome. Journal Of Clinical Psychopharmacology 1998, 18: 324-331.. PMID: 9690699, DOI: 10.1097/00004714-199808000-00013.
Course of Tic Severity in Tourette Syndrome: The First Two DecadesLeckman J, Zhang H, Vitale A, Lahnin F, Lynch K, Bondi C, Kim Y, Peterson B. Course of Tic Severity in Tourette Syndrome: The First Two Decades. Pediatrics 1998, 102: 14-19. PMID: 9651407, DOI: 10.1542/peds.102.1.14.
Tourette's Syndrome: A Failure of Subcortical InhibitionPeterson B, Skudlarski P, Anderson A, Zhang H, Gatenby J, Lacadie C, Leckman J, Gore J. Tourette's Syndrome: A Failure of Subcortical Inhibition. NeuroImage 1998, 7: s1004. DOI: 10.1016/s1053-8119(18)31837-8.
Cingulate-Based Attentional Subsystems in Stroop Word-Color InterferencePeterson B, Skudlarski P, Gatenby J, Zhang H, Anderson A, Gore J. Cingulate-Based Attentional Subsystems in Stroop Word-Color Interference. NeuroImage 1998, 7: s92. DOI: 10.1016/s1053-8119(18)30925-x.
A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette SyndromePeterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC. A Functional Magnetic Resonance Imaging Study of Tic Suppression in Tourette Syndrome. JAMA Psychiatry 1998, 55: 326-333. PMID: 9554428, DOI: 10.1001/archpsyc.55.4.326.
Visual–Motor Integration Functioning in Children With Tourette SyndromeSchultz RT, Carter AS, Gladstone M, Scahill L, Leckman JF, Peterson BS, Zhang H, Cohen DJ, Pauls D. Visual–Motor Integration Functioning in Children With Tourette Syndrome. Neuropsychology 1998, 12: 134-145. PMID: 9460741, DOI: 10.1037/0894-4105.12.1.134.
Symptoms of obsessive-compulsive disorderLeckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.
Cost-effective sib-pair designs in the mapping of quantitative-trait loci.Zhao H, Zhang H, Rotter JI. Cost-effective sib-pair designs in the mapping of quantitative-trait loci. American Journal Of Human Genetics 1997, 60: 1211-21. PMID: 9150169, PMCID: PMC1712450.
Multivariate Adaptive Splines for Analysis of Longitudinal DataZhang H. Multivariate Adaptive Splines for Analysis of Longitudinal Data. Journal Of Computational And Graphical Statistics 1997, 6: 74-91. DOI: 10.1080/10618600.1997.10474728.
Strategies to Identify Genes for Complex DiseasesZhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.
Tree-based, Two-stage Risk Factor Analysis for Spontaneous AbortionZhang H, Bracken M. Tree-based, Two-stage Risk Factor Analysis for Spontaneous Abortion. American Journal Of Epidemiology 1996, 144: 989-996. PMID: 8916510, DOI: 10.1093/oxfordjournals.aje.a008869.
Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes.Zhang H, Risch N. Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. American Journal Of Human Genetics 1996, 59: 951-7. PMID: 8808613, PMCID: PMC1914798.
Risk Factors for Presenting Problems in Child Psychiatric EmergenciesPETERSON B, ZHANG H, SANTA LUCIA R, KING R, LEWIS M. Risk Factors for Presenting Problems in Child Psychiatric Emergencies. Journal Of The American Academy Of Child & Adolescent Psychiatry 1996, 35: 1162-1173. PMID: 8824060, DOI: 10.1097/00004583-199609000-00014.
Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.Risch N, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. American Journal Of Human Genetics 1996, 58: 836-43. PMID: 8644748, PMCID: PMC1914664.
A TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIESZHANG H, HOLFORD T, BRACKEN M. A TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIES. Statistics In Medicine 1996, 15: 37-49. PMID: 8614744, DOI: 10.1002/(sici)1097-0258(19960115)15:1<37::aid-sim144>3.0.co;2-0.
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in HumansRisch N, Zhang H. Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans. Science 1995, 268: 1584-1589. PMID: 7777857, DOI: 10.1126/science.7777857.
Tree-based Risk Factor Analysis of Preterm Delivery and Small-for-Gestational-Age BirthZhang H, Bracken M. Tree-based Risk Factor Analysis of Preterm Delivery and Small-for-Gestational-Age Birth. American Journal Of Epidemiology 1995, 141: 70-78. PMID: 7801968, DOI: 10.1093/oxfordjournals.aje.a117347.

Clinical Trials

Conditions	Study Title
Pregnancy, Childbirth and the Puerperium; Women's Health	Pharmacokinetics and Hepatic Safety of EGCG
Women's Health	FRIEND study- Fibroids and Unexplained Infertility Treatment with Epigallocatechin Gallate; A Natural CompounD in Green Tea

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Heping Zhang, PhD

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