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Govind Rajagopalan

Associate Research Scientist

Research & Publications
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Selected Publications

Protracted Pulmonary Inflammation in IFN-gamma Deficient Mice Recovering From Cytokine Release SyndromeRajagopalan G, Sun Y, Hu B, Harris Z, Stanely G, Koff J. Protracted Pulmonary Inflammation in IFN-gamma Deficient Mice Recovering From Cytokine Release Syndrome. 2023, a1386-a1386. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1386.
Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung InjuryHarris Z, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin H, Manning E, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxia-Induced Lung Injury. 2023, a1256-a1256. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a1256.
A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa InfectionsGeyer J, Krupa K, Harris Z, Sun Y, Sharma L, Würstle S, Hu B, Stanley G, Rajagopalan G, Pellot E, Koff J, Robinson J. A Novel Zinc (II) Porphyrin Is Synergistic with PEV2 Bacteriophage against Pseudomonas aeruginosa Infections. Antibiotics 2023, 12: 735. PMID: 37107097, PMCID: PMC10135120, DOI: 10.3390/antibiotics12040735.
563 Novel porphyrin targets biofilm, Pseudomonas aeruginosa, and Staphylococcus aureusHarris Z, Geyer J, Sun Y, Hu B, Wuerstle S, Stanley G, Rajagopalan G, Robinson J, Koff J. 563 Novel porphyrin targets biofilm, Pseudomonas aeruginosa, and Staphylococcus aureus. Journal Of Cystic Fibrosis 2022, 21: s313-s314. DOI: 10.1016/s1569-1993(22)01253-x.
Lipopolysaccharide Targeted Bacteriophage Therapy Deceases Lung Inflammation in Cystic FibrosisStanley G, Chan B, Kortright K, Sun Y, Rajagopalan G, Harris Z, Turner P, Koff J. Lipopolysaccharide Targeted Bacteriophage Therapy Deceases Lung Inflammation in Cystic Fibrosis. 2022, a3452-a3452. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3452.
Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis in Hyperoxia-Induced Lung InjuryHarris Z, Sun Y, Joerns J, Clark B, Hu B, Korde A, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang M, Koff J. Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis in Hyperoxia-Induced Lung Injury. 2022, a2517-a2517. DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2517.
514: Novel zinc porphyrin antibiotic shows activity against Pseudomonas in vivoHarris Z, Geyer J, Sun Y, Hu B, Stanley G, Rajagopalan G, Robinson J, Koff J. 514: Novel zinc porphyrin antibiotic shows activity against Pseudomonas in vivo. Journal Of Cystic Fibrosis 2021, 20: s243-s244. DOI: 10.1016/s1569-1993(21)01938-x.
499: Bacteriophage therapy decreases cystic fibrosis lung inflammationStanley G, Modak M, Kortright K, Ott I, Sun Y, Korde A, Rajagopalan G, Chan B, Turner P, Koff J. 499: Bacteriophage therapy decreases cystic fibrosis lung inflammation. Journal Of Cystic Fibrosis 2021, 20: s235-s236. DOI: 10.1016/s1569-1993(21)01923-8.
Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis via ERK1/2 in Hyperoxia-Induced Lung InjuryHarris Z, Korde A, Sun Y, Hu B, Rajagopalan G, Stanley G, Joerns J, Clark B, Koff J. Epidermal Growth Factor Receptor (EGFR) Modulates Apoptosis via ERK1/2 in Hyperoxia-Induced Lung Injury. 2021, a4367-a4367. DOI: 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4367.
Staphylococcal enterotoxin B contributes to Staphylococcus aureus systemic infectionBae J, Da F, Liu R, He L, Lv H, Fisher E, Rajagopalan G, Li M, Cheung G, Otto M. Staphylococcal enterotoxin B contributes to Staphylococcus aureus systemic infection. The Journal Of Infectious Diseases 2020, 223: jiaa584-. PMID: 32937658, PMCID: PMC8161638, DOI: 10.1093/infdis/jiaa584.
IL-17A and IFN-gamma Play Distinct Roles in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome Induced by a Staphylococcal SuperantigenRajagopalan G, Coutermarsh-Ott S, Sun Y, Hu B, Harris Z, Stanley G, Koff J. IL-17A and IFN-gamma Play Distinct Roles in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome Induced by a Staphylococcal Superantigen. 2020, a7708-a7708. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7708.
Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor ReceptorHarris Z, Chioccioli M, Joerns J, Clark B, Sun Y, Hu B, Stanley G, Rajagopalan G, Koff J. Novel Imaging of Hyperoxia-Induced Lung Injury Implicates Epidermal Growth Factor Receptor. 2020, a5551-a5551. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5551.
Bacteriophage Therapy Decreases Pseudomonas Aeruginosa Lung InflammationStanley G, Chan B, Ott I, Mayo E, Harris Z, Sun Y, Hu B, Rajagopalan G, Turner P, Koff J. Bacteriophage Therapy Decreases Pseudomonas Aeruginosa Lung Inflammation. 2020, a2977-a2977. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2977.
Lack of correlation of virulence gene profiles of Staphylococcus aureus bacteremia isolates with mortalityPark K, Greenwood-Quaintance K, Cunningham S, Rajagopalan G, Chia N, Jeraldo P, Mandrekar J, Patel R. Lack of correlation of virulence gene profiles of Staphylococcus aureus bacteremia isolates with mortality. Microbial Pathogenesis 2019, 133: 103543. PMID: 31102653, DOI: 10.1016/j.micpath.2019.103543.
Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigensCarnes H, Mehrkens B, Stegman M, Rajagopalan G. Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens. The Journal Of Immunology 2019, 202: 190.34-190.34. DOI: 10.4049/jimmunol.202.supp.190.34.
Gastrointestinal and Extra-Intestinal Manifestations of IgG4–Related DiseaseMiyabe K, Zen Y, Cornell LD, Rajagopalan G, Chowdhary VR, Roberts LR, Chari ST. Gastrointestinal and Extra-Intestinal Manifestations of IgG4–Related Disease. Gastroenterology 2018, 155: 990-1003.e1. PMID: 30012334, DOI: 10.1053/j.gastro.2018.06.082.
Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the MicroenvironmentNie Z, Aboulnasr F, Natesampillai S, Burke S, Krogman A, Bren G, Chung T, Anderson J, Smart M, Katzmann D, Rajagopalan G, Cummins N, Badley A. Correction: Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment. The Journal Of Immunology 2018, 201: ji1800867. PMID: 30006376, PMCID: PMC8592020, DOI: 10.4049/jimmunol.1800867.
Dissecting the pathogenic versus protective roles of IFN-γ and IL-17 in staphylococcal toxic shock syndrome and pneumonia using gene targeted HLA-DR3 transgenic miceRajagopalan G, Krogman A, Chowdhary V. Dissecting the pathogenic versus protective roles of IFN-γ and IL-17 in staphylococcal toxic shock syndrome and pneumonia using gene targeted HLA-DR3 transgenic mice. The Journal Of Immunology 2018, 200: 117.3-117.3. DOI: 10.4049/jimmunol.200.supp.117.3.
Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the MicroenvironmentNie Z, Aboulnasr F, Natesampillai S, Burke S, Krogman A, Bren G, Chung T, Anderson J, Smart M, Katzmann D, Rajagopalan G, Cummins N, Badley A. Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment. The Journal Of Immunology 2018, 200: 1110-1123. PMID: 29263214, PMCID: PMC5808399, DOI: 10.4049/jimmunol.1701113.
Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal SuperantigenChowdhary VR, Krogman A, Tilahun AY, Alexander MP, David CS, Rajagopalan G. Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen. The Journal Of Immunology 2017, 198: 4413-4424. PMID: 28468970, PMCID: PMC5471834, DOI: 10.4049/jimmunol.1601991.
Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome*Festic E, Carr G, Cartin-Ceba R, Hinds R, Banner-Goodspeed V, Bansal V, Asuni A, Talmor D, Rajagopalan G, Frank R, Gajic O, Matthay M, Levitt J. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome*. Critical Care Medicine 2017, 45: 798-805. PMID: 28240689, PMCID: PMC5392150, DOI: 10.1097/ccm.0000000000002284.
Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureusKarau M, Tilahun M, Krogman A, Osborne B, Goldsby R, David C, Mandrekar J, Patel R, Rajagopalan G. Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureus. Virulence 2017, 8: 1148-1159. PMID: 27925510, PMCID: PMC5711449, DOI: 10.1080/21505594.2016.1267894.
HLA‐DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin‐1 in a transgenic mouse modelKrogman A, Tilahun A, David CS, Chowdhary VR, Alexander MP, Rajagopalan G. HLA‐DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin‐1 in a transgenic mouse model. HLA 2016, 89: 20-28. PMID: 27863161, DOI: 10.1111/tan.12930.
Phenotypic and Genotypic Characterization of Staphylococcus aureus Bloodstream Isolates in a Single Large Medical Center in Southeastern MinnesotaPark K, Greenwood-Quaintance K, Schmidt S, Uhl J, Cunningham S, Rajagopalan G, Patel R. Phenotypic and Genotypic Characterization of Staphylococcus aureus Bloodstream Isolates in a Single Large Medical Center in Southeastern Minnesota. Open Forum Infectious Diseases 2016, 3: 1068. DOI: 10.1093/ofid/ofw172.771.
Influence of HLA‐DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse modelSheen Y, Rajagopalan G, Snapper C, Kita H, Wi C, Umaretiya P, Juhn Y. Influence of HLA‐DR polymorphism and allergic sensitization on humoral immune responses to intact pneumococcus in a transgenic mouse model. HLA 2016, 88: 25-34. PMID: 27506953, PMCID: PMC6326101, DOI: 10.1111/tan.12851.
HLA-DR3 transgenic mice expressing Nur77-GFP reveal early and robust activation of T cells by superantigens during Staphylococcus aureus pneumonia.Rajagopalan G, Karau M, Krogman A, Patel R, David C. HLA-DR3 transgenic mice expressing Nur77-GFP reveal early and robust activation of T cells by superantigens during Staphylococcus aureus pneumonia. The Journal Of Immunology 2016, 196: 66.9-66.9. DOI: 10.4049/jimmunol.196.supp.66.9.
Mini-Osmotic Pump Infusion Model to Investigate the Systemic Effects of Chronic Continuous Exposure to Staphylococcal Superantigen in MiceKrogman AL, Chowdhary V, Rajagopalan G. Mini-Osmotic Pump Infusion Model to Investigate the Systemic Effects of Chronic Continuous Exposure to Staphylococcal Superantigen in Mice. 2015, 1396: 109-114. PMID: 26676041, PMCID: PMC4882905, DOI: 10.1007/978-1-4939-3344-0_9.
Superantigen-Producing Staphylococcus aureus Elicits Systemic Immune Activation in a Murine Wound Colonization ModelKim C, Karau M, Greenwood-Quaintance K, Tilahun A, Krogman A, David C, Pritt B, Patel R, Rajagopalan G. Superantigen-Producing Staphylococcus aureus Elicits Systemic Immune Activation in a Murine Wound Colonization Model. Toxins 2015, 7: 5308-5319. PMID: 26670252, PMCID: PMC4690136, DOI: 10.3390/toxins7124886.
A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous LupusChowdhary VR, Dai C, Tilahun AY, Hanson JA, Smart MK, Grande JP, Rajagopalan G, Fu SM, David CS. A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus. The Journal Of Immunology 2015, 195: 4660-4667. PMID: 26475924, PMCID: PMC5292932, DOI: 10.4049/jimmunol.1501073.
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivoHoffmann M, Molina-Mendiola C, Nelson A, Parks C, Reyes E, Hansen M, Rajagopalan G, Pease L, Schrum A, Gil D. Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo. Science Advances 2015, 1: e1500415. PMID: 26601285, PMCID: PMC4646799, DOI: 10.1126/sciadv.1500415.
Superantigens produced by catheter‐associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremiaChung J, Greenwood‐Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter‐associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.
A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020)Hoffmann M, Parks C, Hansen M, Rajagopalan G, Pease L, Schrum A, Gil Pages D. A monomeric fab fragment capable of inducing CD3 conformational change increases T cell receptor reactivity to poorly immunogenic antigens (TUM2P.1020). The Journal Of Immunology 2015, 194: 69.17-69.17. DOI: 10.4049/jimmunol.194.supp.69.17.
Superantigens in Staphylococcus aureus isolated from prosthetic joint infectionKim C, Karau M, Greenwood-Quaintance K, Tilahun A, David C, Mandrekar J, Patel R, Rajagopalan G. Superantigens in Staphylococcus aureus isolated from prosthetic joint infection. Diagnostic Microbiology And Infectious Disease 2014, 81: 201-207. PMID: 25619753, PMCID: PMC4336809, DOI: 10.1016/j.diagmicrobio.2014.11.007.
Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock SyndromeTilahun AY, Chowdhary VR, David CS, Rajagopalan G. Systemic Inflammatory Response Elicited by Superantigen Destabilizes T Regulatory Cells, Rendering Them Ineffective during Toxic Shock Syndrome. The Journal Of Immunology 2014, 193: 2919-2930. PMID: 25092888, PMCID: PMC4157092, DOI: 10.4049/jimmunol.1400980.
The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and PneumoniaTilahun A, Karau M, Ballard A, Gunaratna M, Thapa A, David C, Patel R, Rajagopalan G. The Impact of Staphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia. Mediators Of Inflammation 2014, 2014: 468285. PMID: 25024509, PMCID: PMC4082930, DOI: 10.1155/2014/468285.
Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306)Rajagopalan G, Tilahun A, Chowdhary V. Chronic activation with a staphylococcal superantigen drives the expansion of CD4, CD8 double negative T cells and promotes multiorgan inflammation mimicking systemic lupus erythematosus in HLA class II transgenic mice. (HUM7P.306). The Journal Of Immunology 2014, 192: 184.15-184.15. DOI: 10.4049/jimmunol.192.supp.184.15.
Superantigen profiling of Staphylococcus aureus infective endocarditis isolatesChung J, Karau M, Greenwood-Quaintance K, Ballard A, Tilahun A, Khaleghi S, David C, Patel R, Rajagopalan G. Superantigen profiling of Staphylococcus aureus infective endocarditis isolates. Diagnostic Microbiology And Infectious Disease 2014, 79: 119-124. PMID: 24745820, PMCID: PMC4031024, DOI: 10.1016/j.diagmicrobio.2014.03.009.
Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal MicrobiomeMarietta E, Gomez A, Yeoman C, Tilahun A, Clark C, Luckey D, Murray J, White B, Kudva Y, Rajagopalan G. Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome. PLOS ONE 2013, 8: e78687. PMID: 24236037, PMCID: PMC3827256, DOI: 10.1371/journal.pone.0078687.
Chronic Sub-Cutaneous Exposure to a Staphylococcus Aureus Superantigen, Staphylococcal Enterotoxin B, Elicits an Eosinophilic Airway Inflammation in HLA Class II Transgenic Mice - Linking Atopic Dermatitis (AD) to AsthmaRajagopalan G, Tilahun A, Iijima K, Kita H. Chronic Sub-Cutaneous Exposure to a Staphylococcus Aureus Superantigen, Staphylococcal Enterotoxin B, Elicits an Eosinophilic Airway Inflammation in HLA Class II Transgenic Mice - Linking Atopic Dermatitis (AD) to Asthma. Journal Of Allergy And Clinical Immunology 2013, 131: ab331. DOI: 10.1016/j.jaci.2012.12.1559.
Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking LupusChowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G. Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus. The Journal Of Immunology 2012, 189: 2054-2062. PMID: 22798666, PMCID: PMC3462343, DOI: 10.4049/jimmunol.1201097.
Linezolid Is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA Class II Transgenic MiceKarau M, Tilahun A, Schmidt S, Clark C, Patel R, Rajagopalan G. Linezolid Is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA Class II Transgenic Mice. Antimicrobial Agents And Chemotherapy 2012, 56: 5401-5405. PMID: 22850509, PMCID: PMC3457354, DOI: 10.1128/aac.01080-12.
Is HOT a Cool Treatment for Type 1 Diabetes?Rajagopalan G, Kudva Y, David C. Is HOT a Cool Treatment for Type 1 Diabetes? Diabetes 2012, 61: 1664-1666. PMID: 22723274, PMCID: PMC3379652, DOI: 10.2337/db12-0527.
Detrimental effects of T regulatory cell-promoting IL-2-anti-IL-2 complexes in staphylococcal toxic shock syndrome. (164.13)Rajagopalan G, Tilahun A. Detrimental effects of T regulatory cell-promoting IL-2-anti-IL-2 complexes in staphylococcal toxic shock syndrome. (164.13). The Journal Of Immunology 2012, 188: 164.13-164.13. DOI: 10.4049/jimmunol.188.supp.164.13.
The impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumoniaTilahun A, Karau M, Clark C, Patel R, Rajagopalan G. The impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumonia. Microbes And Infection 2012, 14: 528-536. PMID: 22273732, DOI: 10.1016/j.micinf.2012.01.001.
Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEBTilahun M, Kwan A, Natarajan K, Quinn M, Tilahun A, Xie C, Margulies D, Osborne B, Goldsby R, Rajagopalan G. Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection against Lethal Doses of SEB. PLOS ONE 2011, 6: e27203. PMID: 22102880, PMCID: PMC3216929, DOI: 10.1371/journal.pone.0027203.
HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmDDeshmukh U, Sim D, Dai C, Kannapell C, Gaskin F, Rajagopalan G, David C, Fu S. HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD. Journal Of Autoimmunity 2011, 37: 254-262. PMID: 21868195, PMCID: PMC3372418, DOI: 10.1016/j.jaut.2011.07.002.
Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock SyndromeTilahun A, Marietta E, Wu T, Patel R, David C, Rajagopalan G. Human Leukocyte Antigen Class II Transgenic Mouse Model Unmasks the Significant Extrahepatic Pathology in Toxic Shock Syndrome. American Journal Of Pathology 2011, 178: 2760-2773. PMID: 21641398, PMCID: PMC3124354, DOI: 10.1016/j.ajpath.2011.02.033.
HLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammationRajagopalan G, Tilahun A, Iijima K, David C, Kita H, Juhn Y. HLA‐DR polymorphism modulates response to house dust mites in a transgenic mouse model of airway inflammation. HLA 2011, 77: 589-592. PMID: 21447115, DOI: 10.1111/j.1399-0039.2010.01617.x.
Interferon Gamma-Dependent Intestinal Pathology Contributes to the Lethality in Bacterial Superantigen-Induced Toxic Shock SyndromeTilahun A, Holz M, Wu T, David C, Rajagopalan G. Interferon Gamma-Dependent Intestinal Pathology Contributes to the Lethality in Bacterial Superantigen-Induced Toxic Shock Syndrome. PLOS ONE 2011, 6: e16764. PMID: 21304813, PMCID: PMC3033413, DOI: 10.1371/journal.pone.0016764.
Detrimental Effect of the Proteasome Inhibitor, Bortezomib in Bacterial Superantigen- and Lipopolysaccharide-induced Systemic InflammationTilahun A, Theuer J, Patel R, David C, Rajagopalan G. Detrimental Effect of the Proteasome Inhibitor, Bortezomib in Bacterial Superantigen- and Lipopolysaccharide-induced Systemic Inflammation. Molecular Therapy 2010, 18: 1143-1154. PMID: 20372109, PMCID: PMC2889741, DOI: 10.1038/mt.2010.53.
Potent Neutralization of Staphylococcal Enterotoxin B by Synergistic Action of Chimeric Antibodies▿Tilahun M, Rajagopalan G, Shah-Mahoney N, Lawlor R, Tilahun A, Xie C, Natarajan K, Margulies D, Ratner D, Osborne B, Goldsby R. Potent Neutralization of Staphylococcal Enterotoxin B by Synergistic Action of Chimeric Antibodies▿. Infection And Immunity 2010, 78: 2801-2811. PMID: 20308304, PMCID: PMC2876561, DOI: 10.1128/iai.01121-09.
Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13)rajagopalan G, Tilahun A, David C. Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13). The Journal Of Immunology 2009, 182: 93.13-93.13. DOI: 10.4049/jimmunol.182.supp.93.13.
Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitorRajagopalan G, Tilahun A, Asmann Y, David C. Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor. Physiological Genomics 2009, 37: 279-293. PMID: 19336531, PMCID: PMC2685500, DOI: 10.1152/physiolgenomics.90385.2008.
CYCLOOXYGENASE 2 PATHWAY AND ITS THERAPEUTIC INHIBITION IN SUPERANTIGEN-INDUCED TOXIC SHOCKRajagopalan G, Asmann Y, Lytle A, Tilahun A, Theuer J, Smart M, Patel R, David C. CYCLOOXYGENASE 2 PATHWAY AND ITS THERAPEUTIC INHIBITION IN SUPERANTIGEN-INDUCED TOXIC SHOCK. Shock 2008, 30: 721-728. PMID: 18496243, DOI: 10.1097/shk.0b013e31817048f7.
Regulatory T cells and superantigen‐induced toxic shock. A study using HLA class II transgenic miceRajagopalan G, Epstein B, Lytle A, David C. Regulatory T cells and superantigen‐induced toxic shock. A study using HLA class II transgenic mice. The FASEB Journal 2008, 22: 848.11-848.11. DOI: 10.1096/fasebj.22.1_supplement.848.11.
HLA Class II Transgenic Mice Mimic Human Inflammatory DiseasesMangalam A, Rajagopalan G, Taneja V, David C. HLA Class II Transgenic Mice Mimic Human Inflammatory Diseases. 2008, 97: 65-147. PMID: 18501769, DOI: 10.1016/s0065-2776(08)00002-3.
Evaluating the role of HLA‐DQ polymorphisms on immune response to bacterial superantigens using transgenic miceRajagopalan G, Polich G, Sen M, Singh M, Epstein B, Lytle A, Rouse M, Patel R, David C. Evaluating the role of HLA‐DQ polymorphisms on immune response to bacterial superantigens using transgenic mice. HLA 2007, 71: 135-145. PMID: 18086265, DOI: 10.1111/j.1399-0039.2007.00986.x.
Renal Hemodynamic, Inflammatory, and Apoptotic Responses to Lipopolysaccharide in HO-1−/− MiceTracz M, Juncos J, Grande J, Croatt A, Ackerman A, Rajagopalan G, Knutson K, Badley A, Griffin M, Alam J, Nath K. Renal Hemodynamic, Inflammatory, and Apoptotic Responses to Lipopolysaccharide in HO-1−/− Mice. American Journal Of Pathology 2007, 170: 1820-1830. PMID: 17525251, PMCID: PMC1899452, DOI: 10.2353/ajpath.2007.061093.
Derivation of synergistically acting, neutralizing, chimeric human-mouse anti-SEB monoclonal antibodies (47.35)Tilahun M, Rajagopalan G, Osborne B, Goldsby R. Derivation of synergistically acting, neutralizing, chimeric human-mouse anti-SEB monoclonal antibodies (47.35). The Journal Of Immunology 2007, 178: s73-s73. DOI: 10.4049/jimmunol.178.supp.47.35.
Chronic low-grade exposure to bacterial superantigens elicits sustained T cell expansion and multiorgan inflammation. Implications for autoimmunity. (130.22)Rajagopalan G, Smart M, Grande J, David C. Chronic low-grade exposure to bacterial superantigens elicits sustained T cell expansion and multiorgan inflammation. Implications for autoimmunity. (130.22). The Journal Of Immunology 2007, 178: s232-s232. DOI: 10.4049/jimmunol.178.supp.130.22.
Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhansRajagopalan G, Mangalam A, Sen M, Cheng S, Kudva Y, David C. Autoimmunity in HLA-DQ8 transgenic mice expressing granulocyte/macrophage-colony stimulating factor in the beta cells of islets of langerhans. Autoimmunity 2007, 40: 169-179. PMID: 17453715, DOI: 10.1080/08916930701201083.
Distinct local immunogenic stimuli dictate differential requirements for CD4+ and CD8+ T cell subsets in the pathogenesis of spontaneous autoimmune diabetesRajagopalan G, Mangalam A, Sen M, Kudva Y, David C. Distinct local immunogenic stimuli dictate differential requirements for CD4+ and CD8+ T cell subsets in the pathogenesis of spontaneous autoimmune diabetes. Autoimmunity 2007, 40: 489-496. PMID: 17966038, DOI: 10.1080/08916930701649836.
Delineating the Roles of CD4+ and CD8+ T Cell Subsets in the Pathogenesis of Spontaneous Autoimmune Diabetes Using HLA-DQ8 Transgenic MiceRajagopalan G, Mangalam A, Kudva Y, David C. Delineating the Roles of CD4+ and CD8+ T Cell Subsets in the Pathogenesis of Spontaneous Autoimmune Diabetes Using HLA-DQ8 Transgenic Mice. Clinical Immunology 2007, 123: s71. DOI: 10.1016/j.clim.2007.03.379.
Comment on: Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammationRajagopalan G, Patel R, Kaveri S, David C. Comment on: Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation. Journal Of Antimicrobial Chemotherapy 2006, 59: 157-159. PMID: 17071954, DOI: 10.1093/jac/dkl430.
Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B—Implications for menstrual shockRajagopalan G, Smart M, Murali N, Patel R, David C. Acute systemic immune activation following vaginal exposure to staphylococcal enterotoxin B—Implications for menstrual shock. Journal Of Reproductive Immunology 2006, 73: 51-59. PMID: 17070600, DOI: 10.1016/j.jri.2006.06.007.
Acute Systemic Immune Activation following Conjunctival Exposure to Staphylococcal Enterotoxin BRajagopalan G, Smart M, Patel R, David C. Acute Systemic Immune Activation following Conjunctival Exposure to Staphylococcal Enterotoxin B. Infection And Immunity 2006, 74: 6016-6019. PMID: 16988282, PMCID: PMC1594882, DOI: 10.1128/iai.00671-06.
INTRANASAL EXPOSURE TO STAPHYLOCOCCAL ENTEROTOXIN B ELICITS AN ACUTE SYSTEMIC INFLAMMATORY RESPONSERajagopalan G, Sen M, Singh M, Murali N, Nath K, Iijima K, Kita H, Leontovich A, Gopinathan U, Patel R, David C. INTRANASAL EXPOSURE TO STAPHYLOCOCCAL ENTEROTOXIN B ELICITS AN ACUTE SYSTEMIC INFLAMMATORY RESPONSE. Shock 2006, 25: 647-656. PMID: 16721274, DOI: 10.1097/01.shk.0000209565.92445.7d.
IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic miceRajagopalan G, Kudva Y, Sen M, Marietta E, Murali N, Nath K, Moore J, David C. IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice. Cytokine 2006, 34: 85-95. PMID: 16740391, DOI: 10.1016/j.cyto.2006.04.006.
Intranasal Exposure to Bacterial Superantigens Induces Airway Inflammation in HLA Class II Transgenic MiceRajagopalan G, Iijima K, Singh M, Kita H, Patel R, David C. Intranasal Exposure to Bacterial Superantigens Induces Airway Inflammation in HLA Class II Transgenic Mice. Infection And Immunity 2006, 74: 1284-1296. PMID: 16428778, PMCID: PMC1360368, DOI: 10.1128/iai.74.2.1284-1296.2006.
OR.33. Novel Use of HLA Class II Transgenic ‘Humanized’ Mice in Peanut Allergy ResearchSen M, Rajagopalan G, Maleki S, David C. OR.33. Novel Use of HLA Class II Transgenic ‘Humanized’ Mice in Peanut Allergy Research. Clinical Immunology 2006, 119: s16. DOI: 10.1016/j.clim.2006.04.035.
Su.42. Modulation of Inducible Type 1 Diabetes By Cd137 CostimulationRajagopalan G, Kudva Y, Sen M, David C. Su.42. Modulation of Inducible Type 1 Diabetes By Cd137 Costimulation. Clinical Immunology 2006, 119: s174. DOI: 10.1016/j.clim.2006.04.469.
Endogenous Superantigens Shape Response to Exogenous SuperantigensRajagopalan G, Singh M, Sen M, Murali N, Nath K, David C. Endogenous Superantigens Shape Response to Exogenous Superantigens. MSphere 2005, 12: 1119-1122. PMID: 16148182, PMCID: PMC1235787, DOI: 10.1128/cdli.12.9.1119-1122.2005.
In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide AntagonistsRajagopalan G, Sen M, David C. In Vitro and In Vivo Evaluation of Staphylococcal Superantigen Peptide Antagonists. Infection And Immunity 2004, 72: 6733-6737. PMID: 15501813, PMCID: PMC522998, DOI: 10.1128/iai.72.11.6733-6737.2004.
Autoimmune diabetes in HLA‐DR3/DQ8 transgenic mice expressing the co‐stimulatory molecule B7‐1 in the β cells of islets of LangerhansRajagopalan G, Kudva YC, Chen L, Wen L, David CS. Autoimmune diabetes in HLA‐DR3/DQ8 transgenic mice expressing the co‐stimulatory molecule B7‐1 in the β cells of islets of Langerhans. International Immunology 2003, 15: 1035-1044. PMID: 12917255, DOI: 10.1093/intimm/dxg103.
Expression and function of HLA‐DR3 and DQ8 in transgenic mice lacking functional H2‐MRajagopalan G, Smart M, Cheng S, Krco C, Johnson K, David C. Expression and function of HLA‐DR3 and DQ8 in transgenic mice lacking functional H2‐M. HLA 2003, 62: 149-161. PMID: 12889995, DOI: 10.1034/j.1399-0039.2003.00088.x.
Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor-α Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II MoleculesRajagopalan G, Kudva YC, Flavell RA, David CS. Accelerated Diabetes in Rat Insulin Promoter-Tumor Necrosis Factor-α Transgenic Nonobese Diabetic Mice Lacking Major Histocompatibility Class II Molecules. Diabetes 2003, 52: 342-347. PMID: 12540606, DOI: 10.2337/diabetes.52.2.342.
Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class IIKudva Y, Rajagopalan G, Raju R, Abraham R, Smart M, Hanson J, David C. Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II. Human Immunology 2002, 63: 987-999. PMID: 12392851, DOI: 10.1016/s0198-8859(02)00435-4.
Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant ChainRajagopalan G, Smart M, Krco C, David C. Expression and Function of Transgenic HLA-DQ Molecules and Lymphocyte Development in Mice Lacking Invariant Chain. The Journal Of Immunology 2002, 169: 1774-1783. PMID: 12165499, DOI: 10.4049/jimmunol.169.4.1774.
Staphylococcal enterotoxin B‐induced activation and concomitant resistance to cell death in CD28‐deficient HLA‐DQ8 transgenic miceRajagopalan G, Smart M, Marietta E, David C. Staphylococcal enterotoxin B‐induced activation and concomitant resistance to cell death in CD28‐deficient HLA‐DQ8 transgenic mice. International Immunology 2002, 14: 801-812. PMID: 12096040, DOI: 10.1093/intimm/dxf047.

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