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Margaret Pisani, MD, MPH

Professor of Internal Medicine (Pulmonary, Critical Care & Sleep Medicine)

Contact Information

Margaret Pisani, MD, MPH

Office Location

Mailing Address

  • Pulmonary, Critical Care & Sleep Medicine

    PO Box 208057, 300 Cedar Street

    New Haven, CT 06520-8057

    United States

Research Summary

Dr. Pisani performs clinical research in the field of pulmonary, critical care and sleep medicine. She has focused much of her research on outcomes in older intensive care unit patients. Specifically, she has looked at the prevalence of pre-existing cognitive impairment of patients admitted to the MICU and physician recognition of the impairment. She has also examined risk factors for poor outcomes from ICU care in older patients.

Her work has focused on predisposing risk factors as well as precipitating or modifiable risk factors such as medication use in the intensive care unit. She is interested in delirium, its pathogenesis, treatment and impact on outcomes.

She is currently studying sleep in an intensive care unit population. She is examining risk factors for sleep disruption, use of portable polysomnography in the ICU, and the impact of sleep deprivation on delirium and other ICU outcomes.

She also is a co-investigator in the Interventional Pulmonary (IP) research program where she provides expertise in clinical study design and data analysis. Projects from IP have included studies of the etiology of bilateral pleural effusions, safety of performing thoracentesis in patients with bleeding risks, impact of thoracentesis on dyspnea and quality of life, safety and tolerability of endobronchial ultrasound EBUS under conscious sedation and in obese patients.

Her studies have been funded by the Yale Pepper Center on Aging, American Lung Association, The Chest Foundation, The Hartford Foundation, The Donaghue Foundation and Merck/American Federation on Aging Research and the NIH.

Extensive Research Description

Sleep in the ICU
Treatment of ICU Delirium
Biomarkers for delirium
Outcomes of older ICU patients after critical illness
Outcomes of patients after rapid response team assessments
Outcomes after thoracic interventional procedures


Research Interests

Critical Care; Delirium; Geriatrics; Pleural Diseases; Sleep Deprivation; Epidemiologic Research Design

Selected Publications

Clinical Trials

ConditionsStudy Title
Diseases of the Blood; Infectious DiseasesCrystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)