Marcus Hughes, MD
he/him/his
Assistant ProfessorCards
About
Research
Publications
Featured Publications
Psychedelic Therapies in the United States - Balancing State and Federal Oversight.
Hughes M. Psychedelic Therapies in the United States - Balancing State and Federal Oversight. N Engl J Med 2026, 394: 2281-2283. PMID: 42294853, DOI: 10.1056/NEJMp2518374.Peer-Reviewed Original ResearchToward Greater Diversity in Psychedelic Science.
Hughes M. Toward Greater Diversity in Psychedelic Science. Psychiatr Serv 2026, appips20250169. PMID: 41639945, DOI: 10.1176/appi.ps.20250169.Commentaries, Editorials and LettersEthnoracial inclusion in clinical trials of psychedelics: a systematic review
Hughes M, Garcia-Romeu A. Ethnoracial inclusion in clinical trials of psychedelics: a systematic review. EClinicalMedicine 2024, 74: 102711. PMID: 39050106, PMCID: PMC11268117, DOI: 10.1016/j.eclinm.2024.102711.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSubstance use disordersPsychedelic treatmentNon-White participantsPsychedelic therapySystematic review of PubMed/MedlineNon-Hispanic whitesOpen-label studyReview of PubMed/MedlineNonparametric Mann-Whitney U testMann-Whitney U testSystematic reviewPsychedelic-assisted treatmentRandomized Controlled StudyProportion of whitesPlacebo-ControlledStudies meeting search criteriaClinical trialsNon-Hispanic white participantsWeb of SciencePsychedelic studiesSerotonergic psychedelicsPsychiatric disordersPsychiatric conditionsPsychedelic researchQuality ratings of studies
2026
Electroconvulsive Therapy Following Transmastoid Repair of a Skull-Base Defect and Cerebrospinal Fluid Leak: A Case Report.
Munshi M, Schwartz N, Hughes M. Electroconvulsive Therapy Following Transmastoid Repair of a Skull-Base Defect and Cerebrospinal Fluid Leak: A Case Report. Journal Of Ect 2026 PMID: 41921976, DOI: 10.1097/yct.0000000000001269.Peer-Reviewed Original ResearchElectroconvulsive therapyCerebrospinal fluidIntracranial pressureInitiation of electroconvulsive therapyPostoperative graft integrityBipolar I depressionCerebrospinal fluid leakEarly postoperative periodSkull-base defectsSkull-base surgeryTransmastoid repairClinical improvementFluid leakNeurological complicationsGraft disruptionCase reportPostoperative periodGraft integrationPotential elevationTherapyCement repairRepairStable cognitionOtorrheaElectroconvulsions
2025
Treatment-Resistant Depression
Hughes M, Levine S. Treatment-Resistant Depression. In: England J, ed. Encyclopedia of the Neurological Sciences. 3rd ed. Elsevier - Academic Press; 2025:177-188.Chapters
2024
Nitrous Oxide in the Treatment of Depression: A Brief Review
Hughes, M. E. Nitrous Oxide in the Treatment of Depression: A Brief Review. Am. J. Psychiatry Resid. J. 2024, 20(2), 18–21. https://doi.org/https://doi.org/10.1176/appi.ajp-rj.2024.200207Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSafe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator
Hughes M, Cohen T, Ostroff R, Katz R. Safe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator. Journal Of Ect 2024, 41: e24-e25. PMID: 39589131, DOI: 10.1097/yct.0000000000001089.Peer-Reviewed Original Research
2023
Changing approaches to treating opioid withdrawal in the USA
Hughes M, Edinoff A, Sue K. Changing approaches to treating opioid withdrawal in the USA. The Lancet Psychiatry 2023, 10: 378-380. PMID: 37167986, DOI: 10.1016/s2215-0366(23)00145-1.Commentaries, Editorials and Letters
2022
The Crucial Role of Black, Latinx, and Indigenous Leadership in Harm Reduction and Addiction Treatment
Hughes M, Suhail-Sindhu S, Namirembe S, Jordan A, Medlock M, Tookes HE, Turner J, Gonzalez-Zuniga P. The Crucial Role of Black, Latinx, and Indigenous Leadership in Harm Reduction and Addiction Treatment. American Journal Of Public Health 2022, 112: s136-s139. PMID: 35349317, PMCID: PMC8965189, DOI: 10.2105/ajph.2022.306807.Commentaries, Editorials and Letters
Clinical Trials
Current Trials
AMPA Receptor Components of the Anti-Depressant Ketamine Response
IRB ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 years
Academic Achievements & Community Involvement
News
News
- June 30, 2026
Department of Psychiatry Honors Residents, Fellows, Faculty, Staff at 2026 Annual Commencement Ceremonies
- June 16, 2026Source: The New England Journal of Medicine
Psychedelic Therapies in the United States — Balancing State and Federal Oversight
- February 10, 2026Source: Psychiatric Services
Toward Greater Diversity in Psychedelic Science
- June 21, 2024
Department of Psychiatry Honors Residents, Fellows, Faculty, Staff at 2024 Annual Commencement Ceremonies