Bo Tao, BE, PhD
Associate Research Scientist in Pathology
Research & Publications
Biography
Coauthors
Selected Publications
- An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cellsZhou W, Li W, Wang S, Salovska B, Hu Z, Tao B, Di Y, Punyamurtula U, Turk B, Sessa W, Liu Y. An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells. Nature Communications 2023, 14: 3803. PMID: 37365174, PMCID: PMC10293293, DOI: 10.1038/s41467-023-39514-1.
- Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in miceLee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. DOI: 10.1038/s44161-023-00266-2.
- Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytesRodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes. Hepatology Communications 2022, 6: 2748-2764. PMID: 35852334, PMCID: PMC9512452, DOI: 10.1002/hep4.2042.
- Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cellsFowler JWM, Zhang R, Tao B, Boutagy NE, Sessa WC. Inflammatory stress signaling via NF-kB alters accessible cholesterol to upregulate SREBP2 transcriptional activity in endothelial cells. ELife 2022, 11: e79529. PMID: 35959888, PMCID: PMC9395194, DOI: 10.7554/elife.79529.
- Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular InflammationBernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation. Translational Vision Science & Technology 2021, 10: 21-21. PMID: 34111267, PMCID: PMC8132009, DOI: 10.1167/tvst.10.6.21.
- Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathwayLiu B, Zhou H, Zhang T, Gao X, Tao B, Xing H, Zhuang Z, Dardik A, Kyriakides TR, Goodwin JE. Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway. Angiogenesis 2021, 24: 631-645. PMID: 33650028, PMCID: PMC8292305, DOI: 10.1007/s10456-021-09773-x.
- BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cellsTao B, Kraehling JR, Ghaffari S, Ramirez C, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. Journal Of Biological Chemistry 2020, 295: 18179-18188. PMID: 33097593, PMCID: PMC7939458, DOI: 10.1074/jbc.ra120.015680.
- Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice.Xu J, Tao B, Guo X, Zhou S, Li Y, Zhang Y, Zhou Z, Cheng H, Zhang X, Ke Y. Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-β Activation in the Prevention of Age-Related Emphysema in Mice. Journal Of Immunology (Baltimore, Md. : 1950) 2017, 199: 2323-2332. PMID: 28814604, DOI: 10.4049/jimmunol.1601696.
- Cellular Phenotypic Analysis of Macrophage Activation Unveils Kinetic Responses of Agents Targeting Phosphorylation.Cao Q, Yao J, Li H, Tao B, Cai Y, Xiao P, Cheng H, Ke Y. Cellular Phenotypic Analysis of Macrophage Activation Unveils Kinetic Responses of Agents Targeting Phosphorylation. SLAS Discovery : Advancing Life Sciences R & D 2017, 22: 51-57. PMID: 27554457, DOI: 10.1177/1087057116663166.
- Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cellsKraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, Rotllan N, Zhou W, Nagle MW, Herz J, Williams KJ, Eichmann A, Lee WL, Fernández-Hernando C, Sessa WC. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nature Communications 2016, 7: 13516. PMID: 27869117, PMCID: PMC5121336, DOI: 10.1038/ncomms13516.
- Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitroJin Y, Liu L, Zhang S, Tao B, Tao R, He X, Qu L, Huang J, Wang X, Fu Z. Chromium alters lipopolysaccharide-induced inflammatory responses both in vivo and in vitro. Chemosphere 2016, 148: 436-443. PMID: 26841286, DOI: 10.1016/j.chemosphere.2016.01.057.
- Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.Tao B, Jin W, Xu J, Liang Z, Yao J, Zhang Y, Wang K, Cheng H, Zhang X, Ke Y. Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis. Journal Of Immunology (Baltimore, Md. : 1950) 2014, 193: 2801-11. PMID: 25127857, DOI: 10.4049/jimmunol.1303463.
- Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway.Zhang X, Zhang Y, Tao B, Wang D, Cheng H, Wang K, Zhou R, Xie Q, Ke Y. Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2012, 26: 4603-13. PMID: 22859374, DOI: 10.1096/fj.12-211755.
- Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis.Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng GS, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2012, 26: 2338-50. PMID: 22362894, DOI: 10.1096/fj.11-200139.
- Production of rabbit monoclonal antibodies against mouse embryonic stem cells and identification of pluripotency-associated surface antigens.Tan Z, Zhang J, Su Z, Gu B, Jiang X, Luo J, Ji H, Wang G, Tao B, Zhao X, Chen L, Yu G, Zhu W, Zhang M. Production of rabbit monoclonal antibodies against mouse embryonic stem cells and identification of pluripotency-associated surface antigens. Journal Of Immunological Methods 2011, 365: 149-57. PMID: 21185299, DOI: 10.1016/j.jim.2010.12.012.
- Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells.Gu B, Zhang J, Chen Q, Tao B, Wang W, Zhou Y, Chen L, Liu Y, Zhang M. Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells. Biochemical And Biophysical Research Communications 2010, 394: 418-23. PMID: 20226168, PMCID: PMC2885885, DOI: 10.1016/j.bbrc.2010.03.042.