Mean Ghim, PhD
Associate Research Scientist
Research & Publications
Biography
News
Coauthors
Selected Publications
- Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic ValveAhmad A, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza M, Jung J, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi M. Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve. Journal Of Nuclear Medicine 2023, 64: 1487-1494. PMID: 37321825, PMCID: PMC10478817, DOI: 10.2967/jnumed.123.265516.
- Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathwayRickman M, Ghim M, Pang K, von Huelsen Rocha A, Drudi E, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George S, Weinberg P, Warboys C. Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal Of Cell Science 2023, 136: jcs260449. PMID: 36846872, PMCID: PMC10112981, DOI: 10.1242/jcs.260449.
- Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular IntegritySalarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.
- Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic AneurysmToczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo G, Guzman R, Chaar C, Tellides G, Hassab A, Ye Y, Shoghi K, Zayed M, Gropler R, Sadeghi M. Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2023, 16: e014615. PMID: 36649454, PMCID: PMC9858355, DOI: 10.1161/circimaging.122.014615.
- Shear-mediated ALK5 expression regulates endothelial activationPang K, Ghim M, Sarathchandra P, Warboys C, Yacoub M, Chester A, Weinberg P. Shear-mediated ALK5 expression regulates endothelial activation. Biochemical And Biophysical Research Communications 2022, 642: 90-96. PMID: 36566567, DOI: 10.1016/j.bbrc.2022.12.058.
- NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured EndotheliumGhim M, Yang S, David K, Eustaquio J, Warboys C, Weinberg P. NO Synthesis but Not Apoptosis, Mitosis or Inflammation Can Explain Correlations between Flow Directionality and Paracellular Permeability of Cultured Endothelium. International Journal Of Molecular Sciences 2022, 23: 8076. PMID: 35897652, PMCID: PMC9332325, DOI: 10.3390/ijms23158076.
- Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve CalcificationJung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.
- Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammationGhim M, Pang K, Burnap S, Baig F, Yin X, Arshad M, Mayr M, Weinberg P. Endothelial cells exposed to atheroprotective flow secrete follistatin-like 1 protein which reduces transcytosis and inflammation. Atherosclerosis 2021, 333: 56-66. PMID: 34425528, PMCID: PMC8459397, DOI: 10.1016/j.atherosclerosis.2021.08.025.
- Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α ReceptorPang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, Qiu B, Sarathchandra P, Chester A, Yacoub M, Wilkinson F, Weston R, Warboys C, Hou H, Weinberg P, Wang X. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers In Cell And Developmental Biology 2021, 9: 706143. PMID: 34291056, PMCID: PMC8288075, DOI: 10.3389/fcell.2021.706143.
- Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies.Pang K, Ghim M, Arshad M, Wang X, Weinberg P. Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies. Journal Of Visualized Experiments 2021 PMID: 34152321, DOI: 10.3791/61817.
- Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological StudiesPang K, Ghim M, Arshad M, Wang X, Weinberg P. Segmenting Growth of Endothelial Cells in 6-Well Plates on an Orbital Shaker for Mechanobiological Studies. Journal Of Visualized Experiments 2021 DOI: 10.3791/61817-v.
- Endothelial cells do not align with the mean wall shear stress vectorArshad M, Ghim M, Mohamied Y, Sherwin S, Weinberg P. Endothelial cells do not align with the mean wall shear stress vector. Journal Of The Royal Society Interface 2021, 18: 20200772. PMID: 33435845, PMCID: PMC7879765, DOI: 10.1098/rsif.2020.0772.
- Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysmToczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm. Theranostics 2021, 11: 5876-5888. PMID: 33897887, PMCID: PMC8058712, DOI: 10.7150/thno.55106.
- The Role of Tricellular Junctions in the Transport of Macromolecules Across EndotheliumGhim M, Mohamied Y, Weinberg P. The Role of Tricellular Junctions in the Transport of Macromolecules Across Endothelium. Cardiovascular Engineering And Technology 2020, 12: 101-113. PMID: 32820467, PMCID: PMC7904563, DOI: 10.1007/s13239-020-00483-x.
- Understanding mechanobiology in cultured endothelium: A review of the orbital shaker methodWarboys C, Ghim M, Weinberg P. Understanding mechanobiology in cultured endothelium: A review of the orbital shaker method. Atherosclerosis 2019, 285: 170-177. PMID: 31096159, PMCID: PMC6570700, DOI: 10.1016/j.atherosclerosis.2019.04.210.
- Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow ConditionsZhang G, Pang K, Ghim M, Weinberg P, Tang M. Investigation of Nanodroplet Adhesion to Endothelial Cells Under Atheroprone Flow Conditions. 2018, 00: 1-4. DOI: 10.1109/ultsym.2018.8579749.
- A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediatorGhim M, Pang K, Arshad M, Wang X, Weinberg P. A novel method for segmenting growth of cells in sheared endothelial culture reveals the secretion of an anti-inflammatory mediator. Journal Of Biological Engineering 2018, 12: 15. PMID: 30127849, PMCID: PMC6092814, DOI: 10.1186/s13036-018-0107-6.
- LRG1 is a novel regulator of endothelial activation and is shear dependent: A Potential therapeutic target?Pang K, Fhu C, Ghim M, Tay H, Hou H, Lu Q, Warboys C, Wang X, Weinberg P. LRG1 is a novel regulator of endothelial activation and is shear dependent: A Potential therapeutic target? Atherosclerosis 2018, 275: e37. DOI: 10.1016/j.atherosclerosis.2018.06.094.
- 53LRG1 is a novel regulator of endothelial activation and is shear dependent: a potential therapeutic target?Pang K, Fhu C, Ghim M, Tay H, Hou H, Lu Q, Warboys C, Wang X, Weinberg P. 53LRG1 is a novel regulator of endothelial activation and is shear dependent: a potential therapeutic target? Cardiovascular Research 2018, 114: s13-s14. DOI: 10.1093/cvr/cvy060.023.
- Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flowGhim M, Alpresa P, Yang S, Braakman S, Gray S, Sherwin S, van Reeuwijk M, Weinberg P. Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow. AJP Heart And Circulatory Physiology 2017, 313: h959-h973. PMID: 28754719, PMCID: PMC5792200, DOI: 10.1152/ajpheart.00218.2017.