Suleyman Coskun, PhD, MSc
Associate Research Scientist
Research & Publications
Biography
Locations
Research Summary
My research focus is to identify the key cancer driver genes and their epigenetic regulations in brain tumors. Among various types, we primarily focus on genomic analyses of the two of the most common forms of intracranial tumors, namely meningiomas and gliomas. Integrating ChIP sequencing with RNA-seq and Exome Seq data, we are able to study such complex mechanisms in high-throughput fashion. Modifications to both DNA and histones have a profound effect on transcription and are the best understood of epigenetic changes. Elucidating underlying mechanisms regulating cancer development and progression will lead not only to a better understanding of how the cell of origin may arise in cancer, but also helps to identify root causes to target in order to eradicate cancer.
Coauthors
Public Health Interests
Cancer; Genetics, Genomics, Epigenetics; Metabolism
Selected Publications
- PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humansBarak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmancı AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nature Medicine 2021, 27: 2165-2175. PMID: 34887573, PMCID: PMC8768030, DOI: 10.1038/s41591-021-01572-7.
- 141 Meningioma With Multiple DriversTyrtova E, Li C, Youngblood M, Duran D, Montejo J, Coskun S, Miyagishima D, Bilguvar K, Gunel M. 141 Meningioma With Multiple Drivers. Neurosurgery 2018, 65: 94. DOI: 10.1093/neuros/nyy303.141.
- In utero nanoparticle delivery for site-specific genome editingRicciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications 2018, 9: 2481. PMID: 29946143, PMCID: PMC6018676, DOI: 10.1038/s41467-018-04894-2.
- Correction: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomasHarmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, Baranoski J, Baran B, Carrión-Grant G, Bai H, Mishra-Gorur K, Schramm J, Moliterno J, Vortmeyer AO, Bilgüvar K, Yasuno K, Young RA, Günel M. Correction: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications 2018, 9: 16215. PMID: 29676392, PMCID: PMC5919704, DOI: 10.1038/ncomms16215.
- Integrated genomic analyses of de novo pathways underlying atypical meningiomasHarmancı AS, Youngblood MW, Clark VE, Coşkun S, Henegariu O, Duran D, Erson-Omay EZ, Kaulen LD, Lee TI, Abraham BJ, Simon M, Krischek B, Timmer M, Goldbrunner R, Omay SB, Baranoski J, Baran B, Carrión-Grant G, Bai H, Mishra-Gorur K, Schramm J, Moliterno J, Vortmeyer AO, Bilgüvar K, Yasuno K, Young RA, Günel M. Integrated genomic analyses of de novo pathways underlying atypical meningiomas. Nature Communications 2017, 8: 14433. PMID: 28195122, PMCID: PMC5316884, DOI: 10.1038/ncomms14433.
- Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; ProductionCeneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.
- Constitutive mismatch repair defect syndrome: New insights from whole exome sequencing data and functional studiesCaglayan A, Omay Z, Koksal Y, Coskun S, Unal E, Per H, Bilguvar K, Yasuno K, Ostergaard J, Gunel M. Constitutive mismatch repair defect syndrome: New insights from whole exome sequencing data and functional studies. Journal Of Biotechnology 2016, 231: s12. DOI: 10.1016/j.jbiotec.2016.05.067.
- Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque CalcificationCeneri N, Zhao L, Young B, Healy A, Coskun S, Vasavada H, Yarovinsky T, Ike K, Qin L, Pardi R, Meadows J, Tellides G, Hirschi K, Soufer R, Sadeghi M, Bender J, Morrison A. Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque Calcification. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.655.
- A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETPÇağlayan AO, Tüysüz B, Coşkun S, Quon J, Harmancı AS, Baranoski JF, Baran B, Erson-Omay EZ, Henegariu O, Mane SM, Bilgüvar K, Yasuno K, Günel M. A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP. Journal Of Human Genetics 2016, 61: 395-403. PMID: 26740239, PMCID: PMC4880488, DOI: 10.1038/jhg.2015.160.
- Integrated genomic characterization of IDH1-mutant glioma malignant progressionBai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nature Genetics 2015, 48: 59-66. PMID: 26618343, PMCID: PMC4829945, DOI: 10.1038/ng.3457.
- Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in cultureCuchiara ML, Coşkun S, Banda OA, Horter KL, Hirschi KK, West JL. Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnology And Bioengineering 2015, 113: 870-881. PMID: 26497172, DOI: 10.1002/bit.25848.
- Vascular Niche in HSC Development, Maintenance and RegulationCoşkun S, Hirschi K. Vascular Niche in HSC Development, Maintenance and Regulation. 2015, 191-219. DOI: 10.1007/978-3-319-21705-5_9.
- Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosisErson-Omay EZ, Çağlayan AO, Schultz N, Weinhold N, Omay SB, Özduman K, Köksal Y, Li J, Serin Harmancı A, Clark V, Carrión-Grant G, Baranoski J, Çağlar C, Barak T, Coşkun S, Baran B, Köse D, Sun J, Bakırcıoğlu M, Moliterno Günel J, Pamir MN, Mishra-Gorur K, Bilguvar K, Yasuno K, Vortmeyer A, Huttner AJ, Sander C, Günel M. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology 2015, 17: 1356-1364. PMID: 25740784, PMCID: PMC4578578, DOI: 10.1093/neuonc/nov027.
- Vascular Niche in HSC Development, Maintenance and RegulationTissue-Specific Stem Cell Niche, Springer International Publishing, Turksen, K. (Ed.) (2015)
- Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage CellsCoşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK. Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells. Cell Reports 2014, 9: 581-590. PMID: 25310984, PMCID: PMC4266564, DOI: 10.1016/j.celrep.2014.09.013.
- Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle ControlMarcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK. Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control. Developmental Cell 2013, 27: 504-515. PMID: 24331925, PMCID: PMC3994666, DOI: 10.1016/j.devcel.2013.11.004.
- The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone MarrowSivina M, Yamada T, Park CS, Puppi M, Coskun S, Hirschi K, Lacorazza HD. The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow. Arteriosclerosis Thrombosis And Vascular Biology 2011, 31: 1185-1191. PMID: 21350194, PMCID: PMC3100289, DOI: 10.1161/atvbaha.111.224436.
- Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartmentsCoskun S, Hirschi KK. Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Research Part C Embryo Today Reviews 2010, 90: 229-242. PMID: 21181885, PMCID: PMC5226239, DOI: 10.1002/bdrc.20194.
- Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 ActivityAbbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity. Cell Stem Cell 2010, 7: 606-617. PMID: 21040902, PMCID: PMC3026610, DOI: 10.1016/j.stem.2010.09.013.
- Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plateCoskun S, Korkusuz F, Hasirci V. Hydroxyapatite reinforced poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) based degradable composite bone plate. Journal Of Biomaterials Science Polymer Edition 2005, 16: 1485-1502. PMID: 16366334, DOI: 10.1163/156856205774576727.