Michael Simons
MD, FACC, FAHA
Professor of Medicine (Cardiology)
Research & Publications
Biography
News
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Extensive Research Description
The two principle research themes in the lab are the mechanisms of arterial formation and angiogenic growth factor signaling. These process are investigated at all levels, including in vitro signaling studies, in vivo mouse transgenic and knock-out models and translational studies in larger animal models and early phase clinical trials.
There are 3 major areas of research in my lab:
- Regulation of arterial development and branching morphogenesis The purpose of these studies is to elucidate molecular pathways leading to arterial specification of the endothelium and formation of arterial vasculature. We have recently demonstrated that knockout of synectin, a PDZ protein involved in endosomal trafficking of a number of TK receptor complexes leads to selective reduction in arterial morphogenesis and vascular branching (Chittenden et al Dev Cell, 2006). We have now demonstrated that synectin controls retrograde trafficking of VEGF-R2 containing endosomes via its binding to myosin-VI. Interestingly, myosin-VI knockout in mice or knockdown in zebrafish leads to the same arteriopenic phenotype. This abnormal receptor trafficking results in impaired activation of one of VEGF-R2 signaling pathways that appears to be crucial for arterial specification. Rescue of this aspect of VEGF signaling fully restores arterial morphogenesis not only in synectin null or myosin-VI null mice but in other models of poor arterial development. Thus, this may be the critical pathways specifying arterial formation. Funding: NHLBI (2007-2012)
- Regulation of vascular maintenance. It has not been realized until recently that maintenance of vascular integrity is an active process requiring an ongoing signaling. We have been able to demonstrate that suppression of basal FGF signaling in endothelial cells results in loss of cell-cell contacts and loss of endothelium from the vascular wall (Murakami et al. JCI 2008). The molecular events involved include FGF regulation of VE-cadherin phosphorylation and suppression of local Src activation. Current efforts are focused on characterization of the FGF signaling-VE-cadherin link and elucidation of other pathways regulating VE-cadherin maintenance t the plasma cell membrane Funding: NHLBI (2008-2013).
- Syndecan-4 signaling. Over the years my lab has demonstrated that syndecan-4 plays a critical role in regulation of FGF signaling (Horowitz, JCB ’02 and many others) and that this involves regulation of its trafficking to the plasma membrane rafts and endocytosis among other events (Tkachenko JBC ’02, JCS ’04, Circ Res ’06). Recently we discovered that in addition to its role in FGF signaling syndecan-4 controls formation of mTOR complex 2 and activation of the Akt pathway (Partovian et a l Mol Cell ’08). Among many interesting phenotypes in syndecan-4 null is mice is arterial hypertension (lack of Akt activation leads to suppressed NO production) and defective tumor but not ischemic angiogenesis. We are currently examining molecular events involved in syndecan-4 dependent regulation of mTORC2 formation that apparently include activation of RhoG via a novel mechanism involving sequestration of Rho-GDI (JCB, '09) Funding: NHLBI (2008-2013)
In addition, other emerging projects in the lab include:
- Role of Raf1 and MAPK signaling in regulation of arterial specification: We find that PI3K has the ability to inhibit MAPK signaling by phosphorylating Raf1 and that activation of RAf1 leads to profound stimulation of arterial growth and arterial specification. The molecular details of this pathways are being examined in a variety of transgenic mice models
- Activation of arteriogenesis in arteriogenesis-resistant states: abnormal VEGF and other angiogenic growth factor signaling may be at the core of many events associated with advanced atherosclerosis, diabetes and other angiogenic signaling-resistant states. We are testing the concept that activation of arteriogenic signaling downstream of VEGF-R2 may promore arteriogenesis and become an effective therapeutic approach.
- Molecular mechanisms of fibroblast growth factors (FGF)-dependent regulation of vascular integrity and arteriogenesis. These studies focus on molecular details of FGF-R signaling including receptor endocytosis and trafficking and on FGF-dependent maintenance of VE-cadherin presence in cell-cell junctions. Supported by NIH R01 HL53793
- Arterial branching morphogenesis. These studies are focused on the role of synectin (GIPC), a PDZ-domain containing scaffold molecule regulation of arteriogenesis and arterial branching in development and in adult tissues. Specific problems examined include molecular mechanism of synectin-dependent regulation of VEGF signaling and cell type-specificity of effect. The latter involves generation and analysis of tissue-specific synectin knockouts and synectin null ES cells. Supported by R01 HL84619
- Syndecan signaling in endothelial cells. The project focuses on syndecan-4 signaling, a long standing interest in the lab. Two principle pathways being examined are the regulation of mTOR complex 2 assembly and Akt activation and Rac1 activation and cell motility. Supported by R01 HL53793
- Role of angiogenic inhibitors in the development of pulmonary hypertension. In this collaborative project with Dr Fred Wigley’s laboratory at Johns Hopkins we are examining the. Prevalence of circulating angiogenic inhibitors in patients with scleroderma and their effect on the natural history of disease. Supported by NIH SCCOR P50 HL084946
- Modulation of arteriogenic and metabolic environment in ischemia. The goal of this multi-laboratory collaborative project si to examine therapeutic approaches to preservation of tissue function by modulation of its metabolic state and arterial blood supply. Collaborating laboratories include Peter Carmeliet (European Coordinator, Vesalius Research Center, University of Leuven, Belgium), Holger Gerhardt (Cancer Research UK, London, UK), Luisa Iruela-Arispe (UCLA), Frank Giordano (Yale University) and A. Eichmann (College de France, Paris). Supprted by Leducq Foundation ARTEMIS Network
Coauthors
Public Health Interests
Cardiovascular Diseases
Selected Publications
- Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/SrcSjöberg E, Melssen M, Richards M, Ding Y, Chanoca C, Chen D, Nwadozi E, Pal S, Love D, Ninchoji T, Shibuya M, Simons M, Dimberg A, Claesson-Welsh L. Endothelial VEGFR2-PLCγ signaling regulates vascular permeability and anti-tumor immunity through eNOS/Src. Journal Of Clinical Investigation 2023, 133: e161366. PMID: 37651195, PMCID: PMC10575733, DOI: 10.1172/jci161366.
- Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid AbsorptionZarkada G, Chen X, Zhou X, Lange M, Zeng L, Lv W, Zhang X, Li Y, Zhou W, Liu K, Chen D, Ricard N, Liao J, Kim Y, Benedito R, Claesson-Welsh L, Alitalo K, Simons M, Ju R, Li X, Eichmann A, Zhang F. Chylomicrons Regulate Lacteal Permeability and Intestinal Lipid Absorption. Circulation Research 2023, 133: 333-349. PMID: 37462027, PMCID: PMC10530007, DOI: 10.1161/circresaha.123.322607.
- Acetate controls endothelial-to-mesenchymal transitionZhu X, Wang Y, Soaita I, Lee H, Bae H, Boutagy N, Bostwick A, Zhang R, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder N, Yu L, Arany Z, Simons M. Acetate controls endothelial-to-mesenchymal transition. Cell Metabolism 2023, 35: 1163-1178.e10. PMID: 37327791, PMCID: PMC10529701, DOI: 10.1016/j.cmet.2023.05.010.
- TGFβ signaling pathways in human health and diseaseChen P, Qin L, Simons M. TGFβ signaling pathways in human health and disease. Frontiers In Molecular Biosciences 2023, 10: 1113061. PMID: 37325472, PMCID: PMC10267471, DOI: 10.3389/fmolb.2023.1113061.
- Endothelial-to-mesenchymal transition: advances and controversiesSimons M. Endothelial-to-mesenchymal transition: advances and controversies. Current Opinion In Physiology 2023, 34: 100678. PMID: 37305156, PMCID: PMC10249652, DOI: 10.1016/j.cophys.2023.100678.
- High-resolution visualization of pial surface vessels by flattened whole mount stainingXu Y, Zhang J, Lee H, Zhang G, Bai Y, Simons M. High-resolution visualization of pial surface vessels by flattened whole mount staining. IScience 2023, 26: 106467. PMID: 37020957, PMCID: PMC10067958, DOI: 10.1016/j.isci.2023.106467.
- YES to junctions, no to SrcSimons M, Toomre D. YES to junctions, no to Src. Nature Cardiovascular Research 2022, 1: 1116-1118. PMID: 36938496, PMCID: PMC10021110, DOI: 10.1038/s44161-022-00185-8.
- Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model.Qin L, Jiang B, Zsebo K, Duckers H, Simons M, Chen P. Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model. Journal Of Visualized Experiments 2022 PMID: 36440832, DOI: 10.3791/63839.
- Author Correction: Syndecan-2 selectively regulates VEGF-induced vascular permeabilityCorti F, Ristori E, Rivera-Molina F, Toomre D, Zhang J, Mihailovic J, Zhuang Z, Simons M. Author Correction: Syndecan-2 selectively regulates VEGF-induced vascular permeability. Nature Cardiovascular Research 2022, 1: 592-592. DOI: 10.1038/s44161-022-00092-y.
- Endothelial TGF-β signalling drives vascular inflammation and atherosclerosisChen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.
- Abstract 17070: Bmpr1a and Its Role in Endomt in Pulmonary Arterial HypertensionLee H, Adachi T, Park S, Kowalski P, Anderson D, Simons M, Jin S, Chun H. Abstract 17070: Bmpr1a and Its Role in Endomt in Pulmonary Arterial Hypertension. Circulation 2018, 138 DOI: 10.1161/circ.138.suppl_1.17070.
- Abstract 17179: Blunted Vasoreactivity and Loss of Flow Reserve Contribute to Impaired Arteriogenesis in Diabetic Peripheral Artery DiseaseWang X, Simons M, Sessa W, Zhuang Z. Abstract 17179: Blunted Vasoreactivity and Loss of Flow Reserve Contribute to Impaired Arteriogenesis in Diabetic Peripheral Artery Disease. Circulation 2018, 138 DOI: 10.1161/circ.138.suppl_1.17179.
- SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesisZhou HJ, Xu Z, Wang Z, Zhang H, Zhuang Z, Simons M, Min W. SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis. Nature Communications 2018, 9: 3303. PMID: 30120232, PMCID: PMC6098000, DOI: 10.1038/s41467-018-05812-2.
- Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic developmentWang Y, Baeyens N, Corti F, Tanaka K, Fang J, Zhang J, Jin Y, Coon B, Hirschi K, Schwartz M, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Journal Of Cell Science 2016, 129: e1.1-e1.1. DOI: 10.1242/jcs.200089.
- Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathwayGuo X, Ju R, Cha C, Simons M. Adrenomedullin 2 activates extracellular-signal-regulated kinase in endothelial cells via a protein kinase C α-independent pathway. F1000Research 2016, 5: 26. DOI: 10.12688/f1000research.2420.1.
- Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endotheliumChen PY, Qin L, Tellides G, Simons M. Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium. Science Signaling 2014, 7: ra90. PMID: 25249657, DOI: 10.1126/scisignal.2005504.
- Science Signaling Podcast: 23 September 2014Simons M, VanHook A. Science Signaling Podcast: 23 September 2014. Science Signaling 2014, 7 DOI: 10.1126/scisignal.2005857.
- Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesisMorrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J. Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Journal Of Cell Biology 2014, 206: 2066oia157. DOI: 10.1083/jcb.2066oia157.
- PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial CellsLanahan AA, Lech D, Dubrac A, Zhang J, Zhuang ZW, Eichmann A, Simons M. PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells. Circulation 2014, 130: 902-909. PMID: 24982127, PMCID: PMC6060619, DOI: 10.1161/circulationaha.114.009683.
- The docking protein FRS2α is a critical regulator of VEGF receptors signalingChen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 5514-5519. PMID: 24706887, PMCID: PMC3992672, DOI: 10.1073/pnas.1404545111.
- Endothelial Cell–Dependent Regulation of ArteriogenesisMoraes F, Paye J, Gabhann F, Zhuang ZW, Zhang J, Lanahan AA, Simons M. Endothelial Cell–Dependent Regulation of Arteriogenesis. Circulation Research 2013, 113: 1076-1086. PMID: 23897694, PMCID: PMC3865810, DOI: 10.1161/circresaha.113.301340.
- The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent ArteriogenesisLanahan A, Zhang X, Fantin A, Zhuang Z, Rivera-Molina F, Speichinger K, Prahst C, Zhang J, Wang Y, Davis G, Toomre D, Ruhrberg C, Simons M. The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis. Developmental Cell 2013, 25: 156-168. PMID: 23639442, PMCID: PMC3774154, DOI: 10.1016/j.devcel.2013.03.019.
- Endothelial ERK signaling controls lymphatic fate specificationDeng Y, Atri D, Eichmann A, Simons M. Endothelial ERK signaling controls lymphatic fate specification. Journal Of Clinical Investigation 2013, 123: 1202-1215. PMID: 23391722, PMCID: PMC3582116, DOI: 10.1172/jci63034.
- FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA ExpressionChen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M. FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression. Cell Reports 2012, 2: 1684-1696. PMID: 23200853, PMCID: PMC3534912, DOI: 10.1016/j.celrep.2012.10.021.
- Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and BranchingTirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and Branching. Circulation 2012, 126: 2589-2600. PMID: 23091063, PMCID: PMC3514045, DOI: 10.1161/circulationaha.112.119321.
- Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing MacropinocytosisElfenbein A, Lanahan A, Zhou TX, Yamasaki A, Tkachenko E, Matsuda M, Simons M. Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis. Science Signaling 2012, 5: ra36. PMID: 22569333, PMCID: PMC3827948, DOI: 10.1126/scisignal.2002495.
- Abstract 12: rPAI-123 Inhibits Vasa Vasorum Plexus Development in Atherosclerotic MiceMollmark J, Park A, Wang T, Katzenell S, Shipman S, Zagorchev L, Simons M, Mulligan Kehoe M. Abstract 12: rPAI-123 Inhibits Vasa Vasorum Plexus Development in Atherosclerotic Mice. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a12.
- Frs2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor β-mediated regulation of vascular smooth muscle marker gene expression.Chen P, Simons M, Friesel R. Frs2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor β-mediated regulation of vascular smooth muscle marker gene expression. Journal Of Biological Chemistry 2012, 287: 1609. PMCID: PMC3256868, DOI: 10.1074/jbc.a111.809399.
- FGF‐VEGF crosstalk regulating vascular integrity and angiogenesisMurakami M, Nguyen L, Hatanaka K, Simons M. FGF‐VEGF crosstalk regulating vascular integrity and angiogenesis. The FASEB Journal 2011, 25: 1091.5-1091.5. DOI: 10.1096/fasebj.25.1_supplement.1091.5.
- Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosisEpstein S, Wang J, Peng X, Zhuang Z, Simons M, Xue Z, Burnett M. Aging‐induced collateral impairment: role of arterial rarefaction, decreased eNOS expression/signaling, and increased susceptibility of endothelial cells to apoptosis. The FASEB Journal 2010, 24: 294.3-294.3. DOI: 10.1096/fasebj.24.1_supplement.294.3.
- The FGF system has a key role in regulating vascular integrityMurakami M, Nguyen L, Zhuang Z, Moodie K, Carmeliet P, Stan R, Simons M. The FGF system has a key role in regulating vascular integrity. Journal Of Clinical Investigation 2009, 119: 2113-2113. PMCID: PMC2701855, DOI: 10.1172/jci35298c1.
- Abstract 5566: Recovery of Erk Signaling Restores Defective Angiogenesis and Arteriogenesis in Synectin-Deficient AnimalsRen B, Mukhopadhyay* A, Lanahan A, Zhuang Z, Moodie K, Peterson R, Simons M. Abstract 5566: Recovery of Erk Signaling Restores Defective Angiogenesis and Arteriogenesis in Synectin-Deficient Animals. Circulation 2008, 118 DOI: 10.1161/circ.118.suppl_18.s_576-a.
- Arterial branching morphogenesisSimons M. Arterial branching morphogenesis. The FASEB Journal 2008, 22: 520.1-520.1. DOI: 10.1096/fasebj.22.1_supplement.520.1.
- FGF signaling is a major regulator of coronary tubulogenesis in the murine embryoZheng W, Christensen L, Schatteman G, Murakami M, Simons M, Tomanek R. FGF signaling is a major regulator of coronary tubulogenesis in the murine embryo. The FASEB Journal 2008, 22: 524.3-524.3. DOI: 10.1096/fasebj.22.1_supplement.524.3.
- FGF mediates maintenance of vascular integrity in a Csk dependent mannerMurakami M, Zhuang Z, Moodie K, Stan R, Simons M. FGF mediates maintenance of vascular integrity in a Csk dependent manner. The FASEB Journal 2008, 22: 329.5-329.5. DOI: 10.1096/fasebj.22.1_supplement.329.5.
- Abstract No. 170: Challenge the Surgical Rodent Hindlimb Ischemia Model Using Mini-Interventional TechniqueZhuang Z, Shi J, Moodie K, Rhode J, Tsapakos M, Simons M. Abstract No. 170: Challenge the Surgical Rodent Hindlimb Ischemia Model Using Mini-Interventional Technique. Journal Of Vascular And Interventional Radiology 2008, 19: s65. DOI: 10.1016/j.jvir.2007.12.189.
- Journeys in Coronary AngiogenesisPaye J, Partovian C, Simons M. Journeys in Coronary Angiogenesis. 2008, 561-573. DOI: 10.1007/978-0-387-71518-6_47.
- Abstract 724: Synectin is Required for Normal PDGF Secretion and Smooth Muscle Cell Basic Science RecruitmentPaye J, Chittenden T, Phng L, Gerhardt H, Simons M. Abstract 724: Synectin is Required for Normal PDGF Secretion and Smooth Muscle Cell Basic Science Recruitment. Circulation 2007, 116 DOI: 10.1161/circ.116.suppl_16.ii_136-b.
- Abstract 479: Disruption of Myosin VI Expression Results in Altered Vasculature and VEGF SignalingLanahan A, Kerley-Hamilton J, Moodie K, Zhuang Z, Chittenden T, Simons M. Abstract 479: Disruption of Myosin VI Expression Results in Altered Vasculature and VEGF Signaling. Circulation 2007, 116 DOI: 10.1161/circ.116.suppl_16.ii_81-c.
- Fibroblast Growth FactorsMurakami M, Elfenbein A, Simons M. Fibroblast Growth Factors. 2007, 291-303. DOI: 10.1017/cbo9780511546198.035.
- Introductory Essay: Endothelial Cell CouplingSimons M. Introductory Essay: Endothelial Cell Coupling. 2007, 627-631. DOI: 10.1017/cbo9780511546198.070.
- SyndecansTkachenko E, Rhodes J, Simons M. Syndecans. 2007, 396-402. DOI: 10.1017/cbo9780511546198.045.
- Overview of AngiogenesisElfenbein A, Simons M. Overview of Angiogenesis. 2007, 225-232. DOI: 10.1201/9781420005097-22.
- Fibroblast growth factor system regulates vascular integrity and endothelial permeabilityMurakami M, Nguyen L, Zhuang Z, Moodie K, Stan R, Simons M. Fibroblast growth factor system regulates vascular integrity and endothelial permeability. The FASEB Journal 2007, 21: a187-a187. DOI: 10.1096/fasebj.21.5.a187.
- THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTHMulligan‐Kehoe M, Drinane M, Mollmark J, Simons M. THE ANTI‐ANGIOGENIC ACTIVITY OF rPAI‐123 INHIBITS ANGIOGENIC VASA VASORUM AND ATHERSCLEROTIC PLAQUE GROWTH. The FASEB Journal 2007, 21: a16-a17. DOI: 10.1096/fasebj.21.5.a16-d.
- Synectin‐dependent suppression of basal Rac1 activity is reversed by a signaling pathway involving PKCalpha and RhoGElfenbein A, Simons M. Synectin‐dependent suppression of basal Rac1 activity is reversed by a signaling pathway involving PKCalpha and RhoG. The FASEB Journal 2007, 21: lb11-lb12. DOI: 10.1096/fasebj.21.6.lb11-d.
- Endothelial Activation and Neointimal Hyperplasia: A Double-Edged SwordKhurana R, Simons M. Endothelial Activation and Neointimal Hyperplasia: A Double-Edged Sword. 2007, 75-84. DOI: 10.1007/1-4020-5955-8_4.
- Granzyme B-dependent matrix degradation generates anti-angiostatic activity in scleroderma patientsMulligan-Kehoe M, Drinane M, Casciola-Rosen L, Hummers L, Hall A, Rosen A, Wigley F, Simons M. Granzyme B-dependent matrix degradation generates anti-angiostatic activity in scleroderma patients. Vascular Pharmacology 2006, 45: e147. DOI: 10.1016/j.vph.2006.08.384.
- Syndecan‐4 plays a key role in the phosphorylation of protein kinase B / AktPartovian C, Simons M. Syndecan‐4 plays a key role in the phosphorylation of protein kinase B / Akt. The FASEB Journal 2006, 20: a1080-a1080. DOI: 10.1096/fasebj.20.5.a1080-a.
- Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma PatientsMulligan‐Kehoe M, Drinane M, Hummers L, Hall A, Rosen A, Wigley F, Simons M. Granzyme B‐dependent Matrix Degradation Generates Anti‐Angiostatic Activity in Scleroderma Patients. The FASEB Journal 2006, 20: a1099-a1099. DOI: 10.1096/fasebj.20.5.a1099-a.
- The FGF system positively regulates vascular integrity after ischemic injuryMurakami M, Moodie K, Zhuang Z, Ko I, Stan R, Simons M. The FGF system positively regulates vascular integrity after ischemic injury. The FASEB Journal 2006, 20: a636-a636. DOI: 10.1096/fasebj.20.4.a636-b.
- 1121-52 Inhibition of in-stent restenosis in porcine coronary arteries by copper chelationMandinov L, Moodie K, Mandinova A, Zhuang Z, Maciag T, Simons M, de Muinck E. 1121-52 Inhibition of in-stent restenosis in porcine coronary arteries by copper chelation. Journal Of The American College Of Cardiology 2004, 43: a78. DOI: 10.1016/s0735-1097(04)90323-3.
- Adventitial Angiogenesis Drives Neointima FormationKhurana R, Martin J, Zachary I, Zhuang Z, De Muinck E, Simons M, Bhardwaj S, Yla-Herttuala S, Ferrara N. Adventitial Angiogenesis Drives Neointima Formation. Clinical Science 2004, 106: 1p-1p. DOI: 10.1042/cs106001p.
- Angiogenesis Therapies for Coronary Artery DiseaseSimons M. Angiogenesis Therapies for Coronary Artery Disease. 2003, 0: 407-419. DOI: 10.1385/1-59259-404-2:407.
- Modulation of Microvascular Signaling by Heparan Sulfate Matrix: Studies in Syndecan-4 Transgenic Mice Volume 65, Number 1 (2002), pages 38–46Li J, Parovian C, Li J, Hampton T, Metais C, Tkachenko E, Sellke F, Simons M. Modulation of Microvascular Signaling by Heparan Sulfate Matrix: Studies in Syndecan-4 Transgenic Mice Volume 65, Number 1 (2002), pages 38–46. Microvascular Research 2002, 64: 497. DOI: 10.1006/mvre.2002.2466.
- Syndecan-4-mediated signallingSimons M, Horowitz A. Syndecan-4-mediated signalling. Cellular Signalling 2001, 13: 855-862. PMID: 11728825, DOI: 10.1016/s0898-6568(01)00190-5.
- PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IκBα degradationBao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post M. PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated IκBα degradation. AJP Heart And Circulatory Physiology 2001, 281: h2612-h2618. PMID: 11709430, DOI: 10.1152/ajpheart.2001.281.6.h2612.
- Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery diseaseHenry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Losordo D, Hendel R, Bonow R, Eppler S, Zioncheck T, Holmgren E, McCluskey E. Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease. American Heart Journal 2001, 142: 872-880. PMID: 11685177, DOI: 10.1067/mhj.2001.118471.
- An anti-CD11/CD18 monoclonal antibody in patients with acute myocardial infarction having percutaneous transluminal coronary angioplasty (the FESTIVAL study)Rusnak J, Kopecky S, Clements I, Gibbons R, Holland A, Peterman H, Martin J, Saoud J, Feldman R, Breisblatt W, Simons M, Gessler C, Yu A, Investigators F. An anti-CD11/CD18 monoclonal antibody in patients with acute myocardial infarction having percutaneous transluminal coronary angioplasty (the FESTIVAL study). The American Journal Of Cardiology 2001, 88: 482-487. PMID: 11524054, DOI: 10.1016/s0002-9149(01)01723-4.
- Gene therapy versus protein-based therapy: a matter of pharmacokineticsPost M, Simons M. Gene therapy versus protein-based therapy: a matter of pharmacokinetics. Drug Discovery Today 2001, 6: 769-770. PMID: 11470581, DOI: 10.1016/s1359-6446(01)01904-3.
- Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial IschemiaPearlman J, Gertz Z, Wu Y, Simons M, Post M. Serial Motion Assessment by Reference Tracking (SMART): Application to Detection of Local Functional Impact of Chronic Myocardial Ischemia. Journal Of Computer Assisted Tomography 2001, 25: 558-562. PMID: 11473185, DOI: 10.1097/00004728-200107000-00008.
- Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularizationBao J, Naimark W, Palasis M, Laham R, Simons M, Post M. Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization. Catheterization And Cardiovascular Interventions 2001, 53: 429-434. PMID: 11458429, DOI: 10.1002/ccd.1196.
- Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? *Simons M. Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? *. AJP Heart And Circulatory Physiology 2001, 280: h1923-h1927. PMID: 11299191, DOI: 10.1152/ajpheart.2001.280.5.h1923.
- Pharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery DiseaseBush M, Samara E, Whitehouse MJ, Yoshizawa C, Novicki D, Pike M, Laham R, Simons M, Chronos N. Pharmacokinetics and Pharmacodynamics of Recombinant FGF‐2 in a Phase I Trial in Coronary Artery Disease. The Journal Of Clinical Pharmacology 2001, 41: 378-385. PMID: 11304894, DOI: 10.1177/00912700122010230.
- Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemiaXu X, Li J, Simons M, Li J, Laham R, Sellke F. Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia. Journal Of Thoracic And Cardiovascular Surgery 2001, 121: 735-742. PMID: 11279416, DOI: 10.1067/mtc.2001.112340.
- Therapeutic angiogenesis in cardiology using protein formulationsPost M, Laham R, Sellke F, Simons M. Therapeutic angiogenesis in cardiology using protein formulations. Cardiovascular Research 2001, 49: 522-531. PMID: 11166265, DOI: 10.1016/s0008-6363(00)00216-9.
- GENE TRANSFER FOR ANGIOGENESIS IN CORONARY ARTERY DISEASELaham R, Simons M, Sellke F. GENE TRANSFER FOR ANGIOGENESIS IN CORONARY ARTERY DISEASE. Annual Review Of Medicine 2001, 52: 485-502. PMID: 11160791, DOI: 10.1146/annurev.med.52.1.485.
- Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemiaSato K, Wu T, Laham R, Johnson R, Douglas P, Li J, Sellke F, Bunting S, Simons M, Post M. Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. Journal Of The American College Of Cardiology 2001, 37: 616-623. PMID: 11216988, DOI: 10.1016/s0735-1097(00)01144-x.
- Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibitionMétais C, Bianchi C, Li J, Li J, Simons M, Sellke F. Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition. Basic Research In Cardiology 2001, 96: 59-67. PMID: 11215533, DOI: 10.1007/s003950170078.
- Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation studyLaham R, Chronos N, Pike M, Leimbach M, Udelson J, Pearlman J, Pettigrew R, Whitehouse MJ, Yoshizawa C, Simons M. Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a Phase I open-label dose escalation study. Journal Of The American College Of Cardiology 2000, 36: 2132-2139. PMID: 11127452, DOI: 10.1016/s0735-1097(00)00988-8.
- Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemiaSato K, Laham R, Pearlman J, Novicki D, Sellke F, Simons M, Post M. Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia. The Annals Of Thoracic Surgery 2000, 70: 2113-2118. PMID: 11156130, DOI: 10.1016/s0003-4975(00)02018-x.
- Therapeutic Angiogenesis With Recombinant Fibroblast Growth Factor-2 Improves Stress and Rest Myocardial Perfusion Abnormalities in Patients With Severe Symptomatic Chronic Coronary Artery DiseaseUdelson J, Dilsizian V, Laham R, Chronos N, Vansant J, Blais M, Galt J, Pike M, Yoshizawa C, Simons M. Therapeutic Angiogenesis With Recombinant Fibroblast Growth Factor-2 Improves Stress and Rest Myocardial Perfusion Abnormalities in Patients With Severe Symptomatic Chronic Coronary Artery Disease. Circulation 2000, 102: 1605-1610. PMID: 11015335, DOI: 10.1161/01.cir.102.14.1605.
- Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2 REGULATION OF METALLOPROTEINASE ACTIVITY*Bein K, Simons M. Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2 REGULATION OF METALLOPROTEINASE ACTIVITY*. Journal Of Biological Chemistry 2000, 275: 32167-32173. PMID: 10900205, DOI: 10.1074/jbc.m003834200.
- Clinical Trials in Coronary Angiogenesis: Issues, Problems, ConsensusSimons M, Bonow R, Chronos N, Cohen D, Giordano F, Hammond H, Laham R, Li W, Pike M, Sellke F, Stegmann T, Udelson J, Rosengart T. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. Circulation 2000, 102: e73-86. PMID: 10982554, DOI: 10.1161/01.cir.102.11.e73.
- Molecular multitasking: statins lead to more arteries, less plaqueSimons M. Molecular multitasking: statins lead to more arteries, less plaque. Nature Medicine 2000, 6: 965-966. PMID: 10973306, DOI: 10.1038/79646.
- Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migrationGao Y, Li M, Chen W, Simons M. Synectin, syndecan‐4 cytoplasmic domain binding PDZ protein, inhibits cell migration. Journal Of Cellular Physiology 2000, 184: 373-379. PMID: 10911369, DOI: 10.1002/1097-4652(200009)184:3<373::aid-jcp12>3.0.co;2-i.
- Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptideGao Y, Lecker S, Post M, Hietaranta A, Li J, Volk R, Li M, Sato K, Saluja A, Steer M, Goldberg A, Simons M. Inhibition of ubiquitin-proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide. Journal Of Clinical Investigation 2000, 106: 439-448. PMID: 10930447, PMCID: PMC314329, DOI: 10.1172/jci9826.
- Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery.Laham R, Post M, Sellke F, Simons M. Therapeutic Angiogenesis Using Local Perivascular and Pericardial Delivery. Current Interventional Cardiology Reports 2000, 2: 213-217. PMID: 11096670.
- Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse heartsHampton T, Amende I, Fong J, Laubach V, Li J, Metais C, Simons M. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. AJP Heart And Circulatory Physiology 2000, 279: h260-h268. PMID: 10899065, DOI: 10.1152/ajpheart.2000.279.1.h260.
- Therapeutic AngiogenesisSimons M, Laham R, Post M, Sellke F. Therapeutic Angiogenesis. BioDrugs 2000, 14: 13-20. PMID: 18034552, DOI: 10.2165/00063030-200014010-00002.
- Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial PerfusionHendel R, Henry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Bonow R. Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion. Circulation 2000, 101: 118-121. PMID: 10637195, DOI: 10.1161/01.cir.101.2.118.
- PR39, a peptide regulator of angiogenesisLi J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg R, Hampton T, Li J, Sellke F, Carmeliet P, Simons M. PR39, a peptide regulator of angiogenesis. Nature Medicine 2000, 6: 49-55. PMID: 10613823, DOI: 10.1038/71527.
- Serotonin-Induced Coronary Contraction Increases After Blood Cardioplegia-ReperfusionMétais C, Li J, Li J, Simons M, Sellke F. Serotonin-Induced Coronary Contraction Increases After Blood Cardioplegia-Reperfusion. Circulation 1999, 100 DOI: 10.1161/circ.100.suppl_2.ii-328.
- Serotonin-Induced Coronary Contraction Increases After Blood Cardioplegia-ReperfusionMétais C, Li J, Li J, Simons M, Sellke F. Serotonin-Induced Coronary Contraction Increases After Blood Cardioplegia-Reperfusion. Circulation 1999, 100: ii-328-ii-334. PMID: 10567324, DOI: 10.1161/01.cir.100.suppl_2.ii-328.
- Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass SurgeryLaham R, Sellke F, Edelman E, Pearlman J, Ware J, Brown D, Gold J, Simons M. Local Perivascular Delivery of Basic Fibroblast Growth Factor in Patients Undergoing Coronary Bypass Surgery. Circulation 1999, 100: 1865-1871. PMID: 10545430, DOI: 10.1161/01.cir.100.18.1865.
- Phosphatidylinositol-4,5-bisphosphate Mediates the Interaction of Syndecan-4 with Protein Kinase C †Horowitz A, Murakami M, Gao Y, Simons M. Phosphatidylinositol-4,5-bisphosphate Mediates the Interaction of Syndecan-4 with Protein Kinase C †. Biochemistry 1999, 38: 15871-15877. PMID: 10625452, DOI: 10.1021/bi991363i.
- Angiogenesis in Cardiovascular DiseaseSellke F, Simons M. Angiogenesis in Cardiovascular Disease. Drugs 1999, 58: 391-396. PMID: 10493268, DOI: 10.2165/00003495-199958030-00001.
- Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results.Garcia L, Baim D, Post M, Simons M, Laham R. Therapeutic Angiogenesis Using Endocardial Approach to Administration: Techniques and Results. Current Interventional Cardiology Reports 1999, 1: 222-227. PMID: 11096628.
- Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies.Laham R, Garcia L, Baim D, Post M, Simons M. Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Using Various Delivery Strategies. Current Interventional Cardiology Reports 1999, 1: 228-233. PMID: 11096629.
- The Role of Syndecan Cytoplasmic Domain in Basic Fibroblast Growth Factor-dependent Signal Transduction*Volk R, Schwartz J, Li J, Rosenberg R, Simons M. The Role of Syndecan Cytoplasmic Domain in Basic Fibroblast Growth Factor-dependent Signal Transduction*. Journal Of Biological Chemistry 1999, 274: 24417-24424. PMID: 10446222, DOI: 10.1074/jbc.274.34.24417.
- Attenuation of Endothelium-Dependent Dilation of Pig Pulmonary Arterioles After Cardiopulmonary Bypass Is Prevented by Monoclonal Antibody to Complement C5aPark K, Tofukuji M, Metais C, Comunale M, Dai H, Simons M, Stahl G, Agah A, Sellke F. Attenuation of Endothelium-Dependent Dilation of Pig Pulmonary Arterioles After Cardiopulmonary Bypass Is Prevented by Monoclonal Antibody to Complement C5a. Anesthesia & Analgesia 1999, 89: 42-48.. DOI: 10.1213/00000539-199907000-00008.
- Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a.Park K, Tofukuji M, Metais C, Comunale M, Dai H, Simons M, Stahl G, Agah A, Sellke F. Attenuation of endothelium-dependent dilation of pig pulmonary arterioles after cardiopulmonary bypass is prevented by monoclonal antibody to complement C5a. Anesthesia & Analgesia 1999, 89: 42-8. PMID: 10389776, DOI: 10.1097/00000539-199907000-00008.
- Subxyphoid access of the normal pericardium: A novel drug delivery techniqueLaham R, Simons M, Hung D. Subxyphoid access of the normal pericardium: A novel drug delivery technique. Catheterization And Cardiovascular Interventions 1999, 47: 109-111. PMID: 10385173, DOI: 10.1002/(sici)1522-726x(199905)47:1<109::aid-ccd24>3.0.co;2-3.
- Cloning, Expression, andin VitroActivity of Human EndostatinDhanabal M, Volk R, Ramchandran R, Simons M, Sukhatme V. Cloning, Expression, andin VitroActivity of Human Endostatin. Biochemical And Biophysical Research Communications 1999, 258: 345-352. PMID: 10329390, DOI: 10.1006/bbrc.1999.0595.
- Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*Zhang Y, Pasparakis M, Kollias G, Simons M. Myocyte-dependent Regulation of Endothelial Cell Syndecan-4 Expression ROLE OF TNF-α*. Journal Of Biological Chemistry 1999, 274: 14786-14790. PMID: 10329676, DOI: 10.1074/jbc.274.21.14786.
- Angiographic methods to assess human coronary angiogenesisGibson C, Ryan K, Sparano A, Moynihan J, Rizzo M, Kelley M, Marble S, Laham R, Simons M, McClusky T, Dodge J. Angiographic methods to assess human coronary angiogenesis. American Heart Journal 1999, 137: 169-179. PMID: 9878950, DOI: 10.1016/s0002-8703(99)70473-4.
- Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug deliveryLaham R, Simons M, Hung D. Therapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery. Clinical Cardiology 1999, 22: 6-9. PMID: 9929761, PMCID: PMC6655779, DOI: 10.1002/clc.4960221305.
- Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pigTofukuji M, Metais C, Collard C, Morse D, Stahl G, Nelson D, Li J, Simons M, Sellke F. Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig. The Annals Of Thoracic Surgery 1999, 67: 112-119. PMID: 10086534, DOI: 10.1016/s0003-4975(98)01130-8.
- Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunctionTofukuji M, Stahl G, Agah A, Metais C, Simons M, Sellke F, This study was supported by National Institutes of Health grants HL46716 H. Anti-C5a monoclonal antibody reduces cardiopulmonary bypass and cardioplegia-induced coronary endothelial dysfunction. Journal Of Thoracic And Cardiovascular Surgery 1998, 116: 1060-1068. PMID: 9832699, DOI: 10.1016/s0022-5223(98)70059-5.
- Effects of coronary artery disease on expression and microvascular response to VEGFMétais C, Li J, Li J, Simons M, Sellke F. Effects of coronary artery disease on expression and microvascular response to VEGF. American Journal Of Physiology 1998, 275: h1411-h1418. PMID: 9746492, DOI: 10.1152/ajpheart.1998.275.4.h1411.
- Phosphorylation of the Cytoplasmic Tail of Syndecan-4 Regulates Activation of Protein Kinase Cα*Horowitz A, Simons M. Phosphorylation of the Cytoplasmic Tail of Syndecan-4 Regulates Activation of Protein Kinase Cα*. Journal Of Biological Chemistry 1998, 273: 25548-25551. PMID: 9748216, DOI: 10.1074/jbc.273.40.25548.
- Myb-dependent Regulation of Thrombospondin 2 Expression ROLE OF mRNA STABILITY*Bein K, Ware J, Simons M. Myb-dependent Regulation of Thrombospondin 2 Expression ROLE OF mRNA STABILITY*. Journal Of Biological Chemistry 1998, 273: 21423-21429. PMID: 9694906, DOI: 10.1074/jbc.273.33.21423.
- Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early ResultsSellke F, Laham R, Edelman E, Pearlman J, Simons M. Therapeutic Angiogenesis With Basic Fibroblast Growth Factor: Technique and Early Results. The Annals Of Thoracic Surgery 1998, 65: 1540-1544. PMID: 9647055, DOI: 10.1016/s0003-4975(98)00340-3.
- Regulation of Syndecan-4 Phosphorylation in Vivo *Horowitz A, Simons M. Regulation of Syndecan-4 Phosphorylation in Vivo *. Journal Of Biological Chemistry 1998, 273: 10914-10918. PMID: 9556568, DOI: 10.1074/jbc.273.18.10914.
- Comparison of VEGF Delivery Techniques on Collateral-Dependent Microvascular ReactivitySellke F, Tofukuji M, Laham R, Li J, Hariawala M, Bunting S, Simons M. Comparison of VEGF Delivery Techniques on Collateral-Dependent Microvascular Reactivity. Microvascular Research 1998, 55: 175-178. PMID: 9521892, DOI: 10.1006/mvre.1997.2066.
- Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemiaLopez J, Edelman E, Stamler A, Hibberd M, Prasad P, Thomas K, Disalvo J, Caputo R, Carrozza J, Douglas P, Sellke F, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. American Journal Of Physiology 1998, 274: h930-h936. PMID: 9530206, DOI: 10.1152/ajpheart.1998.274.3.h930.
- Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart diseaseLaham R, Sellke F, Edelman E, Pearlman J, Simons M. Local perivascular basic fibroblast growth factor (bFGF) treatment in patients with ischemic heart disease. Journal Of The American College Of Cardiology 1998, 31: 394. DOI: 10.1016/s0735-1097(98)80061-2.
- Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trialHenry T, Rocha-Singh K, Isner J, Kereiakes D, Giordano F, Simons M, Losordo D, Hendel R, Bonow R, Rothman J, Borbas E, McCluskey E. Results of intracoronary recombinant human vascular endothelial growth factor (rhVEGF) administration trial. Journal Of The American College Of Cardiology 1998, 31: 65. DOI: 10.1016/s0735-1097(98)80928-5.
- c‐Myb function in fibroblastsBein K, Husain M, Ware J, Mucenski M, Rosenberg R, Simons M. c‐Myb function in fibroblasts. Journal Of Cellular Physiology 1997, 173: 319-326. PMID: 9369944, DOI: 10.1002/(sici)1097-4652(199712)173:3<319::aid-jcp3>3.0.co;2-q.
- Macrophage-dependent regulation of syndecan gene expression.Li J, Brown L, Laham R, Volk R, Simons M. Macrophage-dependent regulation of syndecan gene expression. Circulation Research 1997, 81: 785-96. PMID: 9351452, DOI: 10.1161/01.res.81.5.785.
- Extent of myocardial collateralization: Determination with three-dimensional elastic-subtraction spiral CTPearlman J, Laham R, Simons M, Gladstone S, Raptopoulos V. Extent of myocardial collateralization: Determination with three-dimensional elastic-subtraction spiral CT. Academic Radiology 1997, 4: 680-686. PMID: 9344290, DOI: 10.1016/s1076-6332(97)80139-0.
- Rat arterial wall retains myointimal hyperplastic potential long after arterial injury.Sirois M, Simons M, Kuter D, Rosenberg R, Edelman E. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation 1997, 96: 1291-8. PMID: 9286961, DOI: 10.1161/01.cir.96.4.1291.
- c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells.Husain M, Bein K, Jiang L, Alper S, Simons M, Rosenberg R. c-Myb-dependent cell cycle progression and Ca2+ storage in cultured vascular smooth muscle cells. Circulation Research 1997, 80: 617-26. PMID: 9130442, DOI: 10.1161/01.res.80.5.617.
- Enhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells*Harrington E, Löffler J, Nelson P, Kent K, Simons M, Ware J. Enhancement of Migration by Protein Kinase Cα and Inhibition of Proliferation and Cell Cycle Progression by Protein Kinase Cδ in Capillary Endothelial Cells*. Journal Of Biological Chemistry 1997, 272: 7390-7397. PMID: 9054439, DOI: 10.1074/jbc.272.11.7390.
- Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening.Sirois M, Simons M, Edelman E. Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening. Circulation 1997, 95: 669-76. PMID: 9024156, DOI: 10.1161/01.cir.95.3.669.
- Angiogenesis in ischemic heart diseaseWare J, Simons M. Angiogenesis in ischemic heart disease. Nature Medicine 1997, 3: 158-164. PMID: 9018233, DOI: 10.1038/nm0297-158.
- Endogenous Expression Modification: Antisense ApproachesSimons M. Endogenous Expression Modification: Antisense Approaches. 1997, 189: 143-175. DOI: 10.1007/978-1-4615-6277-1_6.
- Direct Vasomotor Effects of Isoflurane in Subepicardial Resistance Vessels from Collateral-dependent and Normal Coronary Circulation of PigsPark K, Lowenstein E, Dai H, Lopez J, Stamler A, Simons M, Sellke F. Direct Vasomotor Effects of Isoflurane in Subepicardial Resistance Vessels from Collateral-dependent and Normal Coronary Circulation of Pigs. Anesthesiology 1996, 85: 584-591.. PMID: 8853089, DOI: 10.1097/00000542-199609000-00018.
- Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemiaSellke F, Li J, Stamler A, Lopez J, Thomas K, Simons M. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 1996, 120: 182-188. PMID: 8751581, DOI: 10.1016/s0039-6060(96)80286-8.
- Food for starving heartsSimons M, Ware J. Food for starving hearts. Nature Medicine 1996, 2: 519-520. PMID: 8616705, DOI: 10.1038/nm0596-519.
- Mantegna et al. Reply:Mantegna R, Buldyrev S, Goldberger A, Havlin S, Peng C, Simons M, Stanley H. Mantegna et al. Reply:. Physical Review Letters 1996, 76: 1979-1981. PMID: 10060574, DOI: 10.1103/physrevlett.76.1979.
- VEGF-induced angiogenesis as an alternate method of revascularization for chronic myocardial ischemia: Improved perfusion and vascular reactivitySellke F, Wang S, Harada K, Lopez J, Simons M. VEGF-induced angiogenesis as an alternate method of revascularization for chronic myocardial ischemia: Improved perfusion and vascular reactivity. Journal Of The American College Of Cardiology 1996, 27: 92-93. DOI: 10.1016/s0735-1097(96)80575-4.
- Smooth muscle cell proliferation, growth and migration in primary and restenotic human coronary atherosclerotic tissueLaham R, Kuntz R, Balm D, Ware J, Slayter H, Schnitt S, Stillman I, Simons M. Smooth muscle cell proliferation, growth and migration in primary and restenotic human coronary atherosclerotic tissue. Journal Of The American College Of Cardiology 1996, 27: 254. DOI: 10.1016/s0735-1097(96)81901-2.
- Perivascular delivery of prolonged half-life aFGF via EVAC results in angiographic collateral development, improvement in coronary flow and function in chronic myocardial ischemiaLopez J, Edelman E, Stambler A, Thomas K, D'Salvo J, Hibberd M, Caputo R, Carrozza J, Douglas P, Sellke F, Simons M. Perivascular delivery of prolonged half-life aFGF via EVAC results in angiographic collateral development, improvement in coronary flow and function in chronic myocardial ischemia. Journal Of The American College Of Cardiology 1996, 27: 30. DOI: 10.1016/s0735-1097(96)80309-3.
- …and surreal antisense?Simons M, Rosenberg R, Edelman E. …and surreal antisense? Nature Medicine 1996, 2: 131-132. PMID: 8574948, DOI: 10.1038/nm0296-131b.
- Local Extravascular Growth Factor Delivery in Myocardial IschemiaLopez J, Simons M. Local Extravascular Growth Factor Delivery in Myocardial Ischemia. Drug Delivery 1996, 3: 143-147. PMID: 26790909, DOI: 10.3109/10717549609029443.
- Antisense Approach to RestenosisSimons M. Antisense Approach to Restenosis. Circulation Journal 1996, 60: 1. PMID: 8648878, DOI: 10.1253/jcj.60.1.
- Statistical and Linguistic Features of DNA SequencesStanley H, Buldyrev S, Goldberger A, Havlin S, Mantegna R, Peng C, Simons M. Statistical and Linguistic Features of DNA Sequences. 1996, 219-234. DOI: 10.1007/978-94-009-1722-4_9.
- Statistical properties of DNA sequencesPeng C, Buldyrev S, Goldberger A, Havlin S, Mantegna R, Simons M, Stanley H. Statistical properties of DNA sequences. Physica A Statistical Mechanics And Its Applications 1995, 221: 180-192. PMID: 11540495, DOI: 10.1016/0378-4371(95)00247-5.
- Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesisPearlman J, Hibberd M, Chuang M, Harada K, Lopez J, Gladstone S, Friedman M, Sellke F, Simons M. Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis. Nature Medicine 1995, 1: 1085-1089. PMID: 7489368, DOI: 10.1038/nm1095-1085.
- β-Adrenergic Modulation of the Collateral-Dependent Coronary MicrocirculationSellke F, Wang S, Friedman M, Bin Dai H, Harada K, Lopez J, Simons M. β-Adrenergic Modulation of the Collateral-Dependent Coronary Microcirculation. Journal Of Surgical Research 1995, 59: 185-190. PMID: 7630126, DOI: 10.1006/jsre.1995.1152.
- c-myc in Vasculoproliferative DiseaseEdelman E, Simons M, Sirois M, Rosenberg R. c-myc in Vasculoproliferative Disease. Circulation Research 1995, 76: 176-182. PMID: 7834827, DOI: 10.1161/01.res.76.2.176.
- Long-range correlations and generalized Lévy walks in DNA sequencesStanley H, Buldyrev S, Goldberger A, Havlin S, Mantegna R, Peng C, Simons M, Stanley M. Long-range correlations and generalized Lévy walks in DNA sequences. 1995, 450: 331-347. DOI: 10.1007/3-540-59222-9_44.
- The Role of TI-201 Perfusion Imaging in Clinical ManagementBetter N, Parker J, Simons M, Rocco T, Gervino E. The Role of TI-201 Perfusion Imaging in Clinical Management. Clinical Nuclear Medicine 1994, 19: 1038. DOI: 10.1097/00003072-199411000-00036.
- FRACTAL LANDSCAPES IN BIOLOGICAL SYSTEMSSTANLEY H, BULDYREV S, GOLDBERGER A, HAVLIN S, OSSADNIK S, PENG C, SIMONS M. FRACTAL LANDSCAPES IN BIOLOGICAL SYSTEMS. 1994, 33-51. DOI: 10.1142/9789814503792_0002.
- Statistical and linguistic features of noncoding DNA: A heterogeneous «Complex system»Stanley H, Buldyrev S, Goldberger A, Havlin S, Mantegna R, Peng C, Simons M. Statistical and linguistic features of noncoding DNA: A heterogeneous «Complex system». Il Nuovo Cimento D 1994, 16: 1339-1356. DOI: 10.1007/bf02462019.
- The impact of clinical data on interpretation of thallium scintigramsSimons M, Parker J, Donohoe K, Udelson J, Gervino E. The impact of clinical data on interpretation of thallium scintigrams. Journal Of Nuclear Cardiology 1994, 1: 365-371. PMID: 9420719, DOI: 10.1007/bf02939957.
- Non-equilibrium dynamics as an indispensable characteristic of a healthy biological systemPeng C, Buldyrev S, Hausdorff J, Havlin S, Mietus J, Simons M, Stanley H, Goldberger A. Non-equilibrium dynamics as an indispensable characteristic of a healthy biological system. Integrative Psychological And Behavioral Science 1994, 29: 283-293. PMID: 7811648, DOI: 10.1007/bf02691332.
- Fractals in biology and medicineStanley H, Buldyrev S, Goldberger A, Havlin S, Mantegna R, Ossadnik S, Peng C, Sciortino F, Simons M. Fractals in biology and medicine. 1994, 438: 147-178. DOI: 10.1007/bfb0031125.
- Fractal Landscapes in Physiology & Medicine: Long-Range Correlations in DNA Sequences and Heart Rate IntervalsPeng C, Buldyrev S, Hausdorff J, Havlin S, Mietus J, Simons M, Stanley H, Goldberger A. Fractal Landscapes in Physiology & Medicine: Long-Range Correlations in DNA Sequences and Heart Rate Intervals. 1994, 55-65. DOI: 10.1007/978-3-0348-8501-0_5.
- Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene familyBuldyrev S, Goldberger A, Havlin S, Peng C, Stanley H, Stanley M, Simons M. Fractal landscapes and molecular evolution: modeling the myosin heavy chain gene family. Biophysical Journal 1993, 65: 2673-2679. PMID: 8312501, PMCID: PMC1226007, DOI: 10.1016/s0006-3495(93)81290-6.
- Long-range power-law correlations in condensed matter physics and biophysicsStanley H, Buldyrev S, Goldberger A, Havlin S, Peng C, Simons M. Long-range power-law correlations in condensed matter physics and biophysics. Physica A Statistical Mechanics And Its Applications 1993, 200: 4-24. DOI: 10.1016/0378-4371(93)90500-4.
- Long-range fractal correlations in DNABuldyrev S, Goldberger A, Havlin S, Peng C, Simons M, Sciortino F, Stanley H. Long-range fractal correlations in DNA. Physical Review Letters 1993, 71: 1776-1776. PMID: 10054495, DOI: 10.1103/physrevlett.71.1776.
- FRACTAL LANDSCAPES IN BIOLOGICAL SYSTEMSSTANLEY H, BULDYREV S, GOLDBERGER A, HAVLIN S, OSSADNIK S, PENG C, SIMONS M. FRACTAL LANDSCAPES IN BIOLOGICAL SYSTEMS. Fractals 1993, 1: 283-301. DOI: 10.1142/s0218348x93000319.
- Generalized Lévy-walk model for DNA nucleotide sequencesBuldyrev S, Goldberger A, Havlin S, Peng C, Simons M, Stanley H. Generalized Lévy-walk model for DNA nucleotide sequences. Physical Review E 1993, 47: 4514-4523. PMID: 9960527, DOI: 10.1103/physreve.47.4514.
- Scaling concepts and complex fluids : long-range power-law correlations in DNASTANLEY H, BULDYREV S, GOLDBERGER A, HAVLIN S, PENG C, SCIORTINO F, SIMONS M. Scaling concepts and complex fluids : long-range power-law correlations in DNA. The European Physical Journal Special Topics 1993, 03: c1-15-c1-25. DOI: 10.1051/jp4:1993102.
- Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after AtherectomySimons M, Leclerc G, Safian R, Isner J, Weir L, Baim D. Relation between Activated Smooth-Muscle Cells in Coronary-Artery Lesions and Restenosis after Atherectomy. New England Journal Of Medicine 1993, 328: 608-613. PMID: 8429852, DOI: 10.1056/nejm199303043280903.
- Fractal Landscapes in Physics and BiologyStanley H, Buldyrev S, Caserta F, Daccord G, Eldred W, Goldberger A, Hausman R, Havlin S, Larralde H, Nittmann J, Peng C, Sciortino F, Simons M, Trunfio P, Weiss G. Fractal Landscapes in Physics and Biology. 1993, 304: 127-136. DOI: 10.1007/978-1-4615-2852-4_14.
- Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivoSimons M, Edelman E, DeKeyser J, Langer R, Rosenberg R. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 1992, 359: 67-70. PMID: 1522889, DOI: 10.1038/359067a0.
- Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosisSimons M, Isner J. Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis. The American Journal Of Cardiology 1992, 69: 425-427. PMID: 1734663, DOI: 10.1016/0002-9149(92)90250-3.
- AORTIC ROOT DIMENSION MEASUREMENT BY FIRST-PASS RADIONUCLIDE ANGIOGRAPHYMartins L, Simons M, Kolodny G, Parker J, Warren S. AORTIC ROOT DIMENSION MEASUREMENT BY FIRST-PASS RADIONUCLIDE ANGIOGRAPHY. Clinical Nuclear Medicine 1991, 16: 292. DOI: 10.1097/00003072-199104000-00029.
- Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoformsLeclerc G, Weir L, Simons M, Kearney M, Rosenfield K, Isner J. Assessement of restenosis vs primary lesions in patients with peripheral vascular disease using in situ hybridization and gene expression of two nonmuscle myosin isoforms. Journal Of The American College Of Cardiology 1991, 17: a105. DOI: 10.1016/0735-1097(91)91387-t.
- In situ hybridization of human atherosclerotic material from coronary arteries and saphenous vein graft biopsied with an atherectomy catheterLeelerc G, Weir L, Simons M, Safian R, Kearney M, Baim D, Isner J. In situ hybridization of human atherosclerotic material from coronary arteries and saphenous vein graft biopsied with an atherectomy catheter. Journal Of The American College Of Cardiology 1991, 17: a73. DOI: 10.1016/0735-1097(91)91258-g.