Ewa Folta-Stogniew, PhD, MSc
Director of Biophysics Resource Keck Laboratory
Research & Publications
Biography
Coauthors
Selected Publications
- Metformin inhibits digestive proteases and impairs protein digestion in miceKelly C, Verdegaal A, Anderson B, Shaw W, Bencivenga-Barry N, Folta-Stogniew E, Goodman A. Metformin inhibits digestive proteases and impairs protein digestion in mice. Journal Of Biological Chemistry 2023, 299: 105363. PMID: 37863262, PMCID: PMC10663847, DOI: 10.1016/j.jbc.2023.105363.
- Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infectionSpiga L, Fansler R, Perera Y, Shealy N, Munneke M, David H, Torres T, Lemoff A, Ran X, Richardson K, Pudlo N, Martens E, Folta-Stogniew E, Yang Z, Skaar E, Byndloss M, Chazin W, Zhu W. Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. Cell Host & Microbe 2023, 31: 1639-1654.e10. PMID: 37776864, PMCID: PMC10599249, DOI: 10.1016/j.chom.2023.08.018.
- Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in miceLee S, Schleer H, Park H, Jang E, Boyer M, Tao B, Gamez-Mendez A, Singh A, Folta-Stogniew E, Zhang X, Qin L, Xiao X, Xu L, Zhang J, Hu X, Pashos E, Tellides G, Shaul P, Lee W, Fernandez-Hernando C, Eichmann A, Sessa W. Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice. Nature Cardiovascular Research 2023, 2: 438-448. DOI: 10.1038/s44161-023-00266-2.
- Gut Commensal Bacteroidetes Encode a Novel Class of Vitamin B12-Binding ProteinsPutnam EE, Abellon-Ruiz J, Killinger BJ, Rosnow JJ, Wexler AG, Folta-Stogniew E, Wright AT, van den Berg B, Goodman AL. Gut Commensal Bacteroidetes Encode a Novel Class of Vitamin B12-Binding Proteins. MBio 2022, 13: e02845-21. PMID: 35227073, PMCID: PMC8941943, DOI: 10.1128/mbio.02845-21.
- Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipidsVanderschuren K, Arranz-Gibert P, Khang M, Hadar D, Gaudin A, Yang F, Folta-Stogniew E, Saltzman WM, Amiram M, Isaacs FJ. Tuning protein half-life in mouse using sequence-defined biopolymers functionalized with lipids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2103099119. PMID: 35046019, PMCID: PMC8794819, DOI: 10.1073/pnas.2103099119.
- Homodimerization enhances both sensitivity and dynamic range of the ligand‐binding domain of type 1 metabotropic glutamate receptorSerebryany E, Folta‐Stogniew E, Liu J, Yan EC. Homodimerization enhances both sensitivity and dynamic range of the ligand‐binding domain of type 1 metabotropic glutamate receptor. FEBS Letters 2016, 590: 4308-4317. PMID: 27800613, PMCID: PMC5154874, DOI: 10.1002/1873-3468.12473.
- Mutational analysis of PopZBowman GR, Perez AM, Ptacin JL, Ighodaro E, Folta‐Stogniew E, Comolli LR, Shapiro L. Mutational analysis of PopZ. Molecular Microbiology 2013, 90: 776-795. PMID: 24102805, PMCID: PMC3859194, DOI: 10.1111/mmi.12398.
- Ligand-Binding Domain of Type 1 Metabotropic Glutamate Receptor is Fully Functional in iTs Monomeric FormSerebryany E, Folta-Stogniew E, Yan E. Ligand-Binding Domain of Type 1 Metabotropic Glutamate Receptor is Fully Functional in iTs Monomeric Form. Biophysical Journal 2011, 100: 552a. DOI: 10.1016/j.bpj.2010.12.3213.
- Nucleobindin 1 is a Calcium Regulated Guanine Nucleotide Dissociation Inhibitor of GαI1Kapoor N, Gupta R, Menon S, folta-Stogniew E, Raleigh D, Sakmar T. Nucleobindin 1 is a Calcium Regulated Guanine Nucleotide Dissociation Inhibitor of GαI1. Biophysical Journal 2011, 100: 86a. DOI: 10.1016/j.bpj.2010.12.673.
- Nucleobindin 1 Is a Calcium-regulated Guanine Nucleotide Dissociation Inhibitor of Gαi1 *Kapoor N, Gupta R, Menon ST, Folta-Stogniew E, Raleigh DP, Sakmar TP. Nucleobindin 1 Is a Calcium-regulated Guanine Nucleotide Dissociation Inhibitor of Gαi1 *. Journal Of Biological Chemistry 2010, 285: 31647-31660. PMID: 20679342, PMCID: PMC2951237, DOI: 10.1074/jbc.m110.148429.
- Quantitative Characterization of the Interactions among c-myc Transcriptional Regulators FUSE, FBP, and FIRHsiao HH, Nath A, Lin CY, Folta-Stogniew EJ, Rhoades E, Braddock DT. Quantitative Characterization of the Interactions among c-myc Transcriptional Regulators FUSE, FBP, and FIR. Biochemistry 2010, 49: 4620-4634. PMID: 20420426, DOI: 10.1021/bi9021445.
- Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site*Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, Ha Y. Structural Characterization of the E2 Domain of APL-1, a Caenorhabditis elegans Homolog of Human Amyloid Precursor Protein, and Its Heparin Binding Site*. Journal Of Biological Chemistry 2009, 285: 2165-2173. PMID: 19906646, PMCID: PMC2804372, DOI: 10.1074/jbc.m109.018432.
- Macromolecular Interactions: Light ScatteringFolta‐Stogniew E. Macromolecular Interactions: Light Scattering. 2009 DOI: 10.1002/9780470015902.a0003143.
- Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2Casuscelli J, Schmidt S, DeGray B, Petri ET, Ćelić A, Folta-Stogniew E, Ehrlich BE, Boggon TJ. Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2. American Journal Of Physiology. Renal Physiology 2009, 297: f1310-f1315. PMID: 19726544, PMCID: PMC2781345, DOI: 10.1152/ajprenal.00412.2009.
- Reexamination of the Role of the Amino Terminus of SecA in Promoting Its Dimerization and Functional State▿Das S, Stivison E, Folta-Stogniew E, Oliver D. Reexamination of the Role of the Amino Terminus of SecA in Promoting Its Dimerization and Functional State▿. Journal Of Bacteriology 2008, 190: 7302-7307. PMID: 18723626, PMCID: PMC2580686, DOI: 10.1128/jb.00593-08.
- Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c‐myc inhibitionCrichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De La Cruz EM, Levens D, Lolis E, Braddock D. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c‐myc inhibition. The EMBO Journal 2007, 27: 277-289. PMID: 18059478, PMCID: PMC2206118, DOI: 10.1038/sj.emboj.7601936.
- Keck Foundation Biotechnology Resource Laboratory, Yale University.Stone KL, Bjornson RD, Blasko GG, Bruce C, Cofrancesco R, Carriero NJ, Colangelo CM, Crawford JK, Crawford JM, daSilva NC, Deluca JD, Elliott JI, Elliott MM, Flory PJ, Folta-Stogniew EJ, Gulcicek E, Kong Y, Lam TT, Lee JY, Lin A, LoPresti MB, Mane SM, McMurray WJ, Tikhonova IR, Westman S, Williams NA, Wu TL, Hongyu Z, Williams KR. Keck Foundation Biotechnology Resource Laboratory, Yale University. The Yale Journal Of Biology And Medicine 2007, 80: 195-211. PMID: 18449392, PMCID: PMC2347368.
- The structural basis of cyclic diguanylate signal transduction by PilZ domainsBenach J, Swaminathan SS, Tamayo R, Handelman SK, Folta‐Stogniew E, Ramos JE, Forouhar F, Neely H, Seetharaman J, Camilli A, Hunt JF. The structural basis of cyclic diguanylate signal transduction by PilZ domains. The EMBO Journal 2007, 26: 5153-5166. PMID: 18034161, PMCID: PMC2140105, DOI: 10.1038/sj.emboj.7601918.
- Oligomeric States of Proteins Determined by Size-Exclusion Chromatography Coupled With Light Scattering, Absorbance, and Refractive Index DetectorsFolta-Stogniew E. Oligomeric States of Proteins Determined by Size-Exclusion Chromatography Coupled With Light Scattering, Absorbance, and Refractive Index Detectors. 2006, 328: 97-112. PMID: 16785643, DOI: 10.1385/1-59745-026-x:97.
- Exchange of DNA Base Pairs that Coincides with Recognition of Homology Promoted by E. coli RecA ProteinFolta-Stogniew E, O'Malley S, Gupta R, Anderson KS, Radding CM. Exchange of DNA Base Pairs that Coincides with Recognition of Homology Promoted by E. coli RecA Protein. Molecular Cell 2004, 15: 965-975. PMID: 15383285, DOI: 10.1016/j.molcel.2004.08.017.
- Trimeric Subunit Stoichiometry of the Glutamate Transporters from Bacillus caldotenax and Bacillus stearothermophilus †Yernool D, Boudker O, Folta-Stogniew E, Gouaux E. Trimeric Subunit Stoichiometry of the Glutamate Transporters from Bacillus caldotenax and Bacillus stearothermophilus †. Biochemistry 2003, 42: 12981-12988. PMID: 14596613, DOI: 10.1021/bi030161q.
- Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination ProteinGupta R, Folta-Stogniew E, O'Malley S, Takahashi M, Radding C. Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein. Molecular Cell 1999, 4: 705-714. PMID: 10619018, DOI: 10.1016/s1097-2765(00)80381-0.
- Determination of molecular masses of proteins in solution: Implementation of an HPLC size exclusion chromatography and laser light scattering service in a core laboratory.Folta-Stogniew E, Williams KR. Determination of molecular masses of proteins in solution: Implementation of an HPLC size exclusion chromatography and laser light scattering service in a core laboratory. Journal Of Biomolecular Techniques 1999, 10: 51-63. PMID: 19499008, PMCID: PMC2291588.
- Human Rad51 Protein Can Form Homologous Joints in the Absence of Net Strand Exchange*Gupta R, Folta-Stogniew E, Radding C. Human Rad51 Protein Can Form Homologous Joints in the Absence of Net Strand Exchange*. Journal Of Biological Chemistry 1999, 274: 1248-1256. PMID: 9880493, DOI: 10.1074/jbc.274.3.1248.
- RecA tests homology at both pairing and strand exchangeBazemore L, Folta-Stogniew E, Takahashi M, Radding C. RecA tests homology at both pairing and strand exchange. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 11863-11868. PMID: 9342328, PMCID: PMC23638, DOI: 10.1073/pnas.94.22.11863.
- Base-Catalysis of Imino Proton Exchange in DNA: Effects of Catalyst upon DNA Structure and DynamicsFolta-Stogniew E, Russu I. Base-Catalysis of Imino Proton Exchange in DNA: Effects of Catalyst upon DNA Structure and Dynamics. Biochemistry 1996, 35: 8439-8449. PMID: 8679602, DOI: 10.1021/bi952932z.
- Energetics of base pair opening in a DNA dodecamer containing an A 3 T 3 tractMoe J, Folta-Stogniew E, Russu I. Energetics of base pair opening in a DNA dodecamer containing an A 3 T 3 tract. Nucleic Acids Research 1995, 23: 1984-1989. PMID: 7596827, PMCID: PMC306973, DOI: 10.1093/nar/23.11.1984.
- Sequence dependence of base-pair opening in a DNA dodecamer containing the CACA/GTGT sequence motif.Folta-Stogniew E, Russu I. Sequence dependence of base-pair opening in a DNA dodecamer containing the CACA/GTGT sequence motif. Biochemistry 1994, 33: 11016-24. PMID: 8086418, DOI: 10.1021/bi00202a022.