Yulia Surovtseva
Director 3; Postdoctoral Fellow; Postdoctoral Fellow
Research & Publications
Biography
News
Coauthors
Selected Publications
- Abstract P5-17-01: Targeting Acetyl-CoA carboxylase in pre-clinical breast cancer modelsFoldi J, Marczyk M, Gunasekharan V, Qing T, Sehgal R, Shan N, Muthusamy V, Umlau S, Surovtseva Y, Kibbey R, Pusztai L. Abstract P5-17-01: Targeting Acetyl-CoA carboxylase in pre-clinical breast cancer models. Cancer Research 2022, 82: p5-17-01-p5-17-01. DOI: 10.1158/1538-7445.sabcs21-p5-17-01.
- Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action StudiesWernke KM, Tirla A, Xue M, Surovtseva YV, Menges FS, Herzon SB. Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure–Activity Relationships and Facilitates Mechanism of Action Studies. Journal Of The American Chemical Society 2021, 143: 15824-15833. PMID: 34524796, DOI: 10.1021/jacs.1c07559.
- 854 Functional drug screening identifies candidate synergistic combinations for CTCL therapyYumeen S, Mirza F, Lewis J, King A, Kim S, Carlson K, Umlauf S, Surovtseva Y, Foss F, Girardi M. 854 Functional drug screening identifies candidate synergistic combinations for CTCL therapy. Journal Of Investigative Dermatology 2020, 140: s111. DOI: 10.1016/j.jid.2020.03.870.
- Screening Novel Agent Combinations to Expedite CTCL Therapeutic DevelopmentMirza FN, Yumeen S, Lewis JM, King ALO, Kim S, Carlson KR, Umlauf S, Surovtseva YV, Foss FM, Girardi M. Screening Novel Agent Combinations to Expedite CTCL Therapeutic Development. Journal Of Investigative Dermatology 2020, 141: 217-221. PMID: 32534802, DOI: 10.1016/j.jid.2020.05.097.
- JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCLYumeen S, Mirza FN, Lewis JM, King ALO, Kim SR, Carlson KR, Umlauf SR, Surovtseva YV, Foss FM, Girardi M. JAK inhibition synergistically potentiates BCL2, BET, HDAC, and proteasome inhibition in advanced CTCL. Blood Advances 2020, 4: 2213-2226. PMID: 32437546, PMCID: PMC7252559, DOI: 10.1182/bloodadvances.2020001756.
- 676 Exploring novel therapeutic targets in the treatment of cutaneous T-cell lymphomaYumeen S, King A, Kim S, Lewis J, Carlson K, Umlauf S, Surovtseva Y, Foss F, Girardi M. 676 Exploring novel therapeutic targets in the treatment of cutaneous T-cell lymphoma. Journal Of Investigative Dermatology 2019, 139: s116. DOI: 10.1016/j.jid.2019.03.752.
- Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host BacteriaShine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM. Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria. ACS Chemical Biology 2018, 13: 3286-3293. PMID: 30403848, PMCID: PMC7001666, DOI: 10.1021/acschembio.8b00714.
- High throughput discovery of novel regulators of human ribosome biogenesisBaserga S, Farley‐Barnes K, McCann K, Ogawa L, Merkel J, Surovtseva Y. High throughput discovery of novel regulators of human ribosome biogenesis. The FASEB Journal 2018, 32: 526.25-526.25. DOI: 10.1096/fasebj.2018.32.1_supplement.526.25.
- Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and RadiationCorso C, Bindra R, Glazer P, Sulkowski P, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra-Gorur K, De Feyter H, de Graaf R, Surovtseva Y, Kachman M, Halene S, Gunel M. Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation. International Journal Of Radiation Oncology • Biology • Physics 2017, 99: e68. DOI: 10.1016/j.ijrobp.2017.06.754.
- Abstract LB-290: Oncometabolites induce a BRCAness state that can be exploited by PARP inhibitorsSulkowski P, Corso C, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra K, Feyter H, Graaf R, Surovtseva Y, Kachman M, Halene S, Gunel M, Glazer P, Bindra R. Abstract LB-290: Oncometabolites induce a BRCAness state that can be exploited by PARP inhibitors. Cancer Research 2017, 77: lb-290-lb-290. DOI: 10.1158/1538-7445.am2017-lb-290.
- DIPG-33. BIOLOGICAL CHARACTERIZATION OF PPM1D MUTATIONS IN THE CONTEXT OF DIPGFons N, Sundaram R, Surovtseva Y, Rusin S, Kettenbach A, Breuer G, Bindra R. DIPG-33. BIOLOGICAL CHARACTERIZATION OF PPM1D MUTATIONS IN THE CONTEXT OF DIPG. Neuro-Oncology 2017, 19: iv12-iv12. PMCID: PMC5475004, DOI: 10.1093/neuonc/nox083.048.
- Abstract B25: “TargetDBR”—A DNA repair drug and target discovery collaboration: Exploiting synthetic lethal, high content, and functional cellular reporter assays to accelerate DNA repair targeted drug discoveryHollick J, Abriola L, Bono F, Hegan D, Klingbeil P, Liu Y, Sundaram R, Surovtseva Y, Whittaker M, Bindra R, Glazer P. Abstract B25: “TargetDBR”—A DNA repair drug and target discovery collaboration: Exploiting synthetic lethal, high content, and functional cellular reporter assays to accelerate DNA repair targeted drug discovery. Molecular Cancer Research 2017, 15: b25-b25. DOI: 10.1158/1557-3125.dnarepair16-b25.
- RNF8 Regulates Nonhomologous End Joining and DNA-PK Recruitment to DNA Double-Strand Break SitesGao S, Surovtseva Y, Bindra R. RNF8 Regulates Nonhomologous End Joining and DNA-PK Recruitment to DNA Double-Strand Break Sites. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s55. DOI: 10.1016/j.ijrobp.2016.06.143.
- Abstract 2174: A high-throughput, high-content assay for the discovery of new inhibitors of DNA double-strand break repairSurovtseva Y, Jairam V, Sundaram R, Bindra R, Herzon S. Abstract 2174: A high-throughput, high-content assay for the discovery of new inhibitors of DNA double-strand break repair. Cancer Research 2016, 76: 2174-2174. DOI: 10.1158/1538-7445.am2016-2174.
- Abstract 2466: Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell linesFons N, Surovtseva Y, Breuer G, Sundaram R, Bindra R. Abstract 2466: Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell lines. Cancer Research 2016, 76: 2466-2466. DOI: 10.1158/1538-7445.am2016-2466.
- Identification and Characterization of Novel DNA Repair Inhibitors as Potential Tumor Cell RadiosensitizersJairam V, Sundaram R, Breuer G, Surovtseva Y, Bindra R. Identification and Characterization of Novel DNA Repair Inhibitors as Potential Tumor Cell Radiosensitizers. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: s48. DOI: 10.1016/j.ijrobp.2015.07.116.
- Abstract 417: Endosome-Based Activation of Non-Canonical NF-kB Signaling by Complement Membrane Attack ComplexesJane-wit D, Surovtseva Y, Qin L, Liu R, Clark P, Manes T, Wang C, Kashgarian M, Kirkiles-Smith N, Tellides G, Pober J. Abstract 417: Endosome-Based Activation of Non-Canonical NF-kB Signaling by Complement Membrane Attack Complexes. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.417.
- High-Throughput RNAi Screening Platform Identifies Novel Regulators of DNA Double-Strand Break Repair PathwaysSalem A, Surovtseva Y, Sundaram R, Bindra R. High-Throughput RNAi Screening Platform Identifies Novel Regulators of DNA Double-Strand Break Repair Pathways. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s34-s35. DOI: 10.1016/j.ijrobp.2014.05.146.
- High-Content, High-Throughput Screening for Novel Double-Strand Break Repair InhibitorsSalem A, Sundaram R, Surovtseva Y, Bindra R. High-Content, High-Throughput Screening for Novel Double-Strand Break Repair Inhibitors. International Journal Of Radiation Oncology • Biology • Physics 2013, 87: s654. DOI: 10.1016/j.ijrobp.2013.06.1732.
- Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher EukaryotesSurovtseva Y, Churikov D, Boltz K, Song X, Lamb J, Warrington R, Leehy K, Heacock M, Price C, Shippen D. Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes. Molecular Cell 2009, 36: 207-218. PMID: 19854131, PMCID: PMC2768651, DOI: 10.1016/j.molcel.2009.09.017.
- STN1 protects chromosome ends in Arabidopsis thalianaSong X, Leehy K, Warrington R, Lamb J, Surovtseva Y, Shippen D. STN1 protects chromosome ends in Arabidopsis thaliana. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 19815-19820. PMID: 19064932, PMCID: PMC2604966, DOI: 10.1073/pnas.0807867105.
- Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenanceSurovtseva Y, Shakirov E, Vespa L, Osbun N, Song X, Shippen D. Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance. The EMBO Journal 2007, 26: 3653-3661. PMID: 17627276, PMCID: PMC1949013, DOI: 10.1038/sj.emboj.7601792.
- The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End ProtectionShakirov E, Surovtseva Y, Osbun N, Shippen D. The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection. Molecular And Cellular Biology 2005, 25: 7725-7733. PMID: 16107718, PMCID: PMC1190295, DOI: 10.1128/mcb.25.17.7725-7733.2005.
- A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *Karamysheva Z, Surovtseva Y, Vespa L, Shakirov E, Shippen D. A C-terminal Myb Extension Domain Defines a Novel Family of Double-strand Telomeric DNA-binding Proteins in Arabidopsis *. Journal Of Biological Chemistry 2004, 279: 47799-47807. PMID: 15364931, DOI: 10.1074/jbc.m407938200.
- A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiaeBogomolnaya L, Pathak R, Cham R, Guo J, Surovtseva Y, Jaeckel L, Polymenis M. A new enrichment approach identifies genes that alter cell cycle progression in Saccharomyces cerevisiae. Current Genetics 2004, 45: 350-359. PMID: 15022016, DOI: 10.1007/s00294-004-0497-5.