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Timur Yarovinsky, MD, PhD

Research Scientist (Cardiovascular Medicine)

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Selected Publications

Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrenceChen J, Madina B, Ahmadi E, Yarovinsky T, Krady M, Meehan E, Wang I, Ye X, Pitmon E, Ma X, Almassian B, Nakaar V, Wang K. Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence. Acta Pharmaceutica Sinica B 2024, 14: 335-349. DOI: 10.1016/j.apsb.2023.08.034.
Fishing for “complements” with vascular organoid models of microvascular diseaseGu S, Yarovinsky T, Hwa J. Fishing for “complements” with vascular organoid models of microvascular disease. Cell Stem Cell 2023, 30: 1285-1286. PMID: 37802032, DOI: 10.1016/j.stem.2023.09.004.
Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophagesWilcox N, Yarovinsky T, Pandya P, Ramgolam V, Moro A, Wu Y, Nicoli S, Hirschi K, Bender J. Distinct hypoxia-induced translational profiles of embryonic and adult-derived macrophages. IScience 2023, 26: 107985. PMID: 38047075, PMCID: PMC10690575, DOI: 10.1016/j.isci.2023.107985.
Immune modulation of innate and adaptive responses by CARG-2020 restore immunosurveillance and establish anti-tumoral immunological memory (049)Alvero A, Fox A, Madina B, Krady M, Gogoi R, Yarovinsky T, Nakaar V, Almassian B, Mor G. Immune modulation of innate and adaptive responses by CARG-2020 restore immunosurveillance and establish anti-tumoral immunological memory (049). Gynecologic Oncology 2023, 176: s42. DOI: 10.1016/j.ygyno.2023.06.522.
Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fireYarovinsky T, Su M, Chen C, Xiang Y, Tang W, Hwa J. Pyroptosis in cardiovascular diseases: Pumping gasdermin on the fire. Seminars In Immunology 2023, 69: 101809. PMID: 37478801, PMCID: PMC10528349, DOI: 10.1016/j.smim.2023.101809.
Abstract 219: Translational Profiling Of Embryonic And Adult-derived Macrophages Exposed To HypoxiaYarovinsky T, Wilcox N, Pandya P, Ramgolam V, Moro A, Wu Y, Nicoli S, Hirschi K, Bender J. Abstract 219: Translational Profiling Of Embryonic And Adult-derived Macrophages Exposed To Hypoxia. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43 DOI: 10.1161/atvb.43.suppl_1.219.
Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cellsTyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.
Virus‐Like Vesicles (VLVs) as Therapeutic Vaccine Vectors for Hepatocellular CarcinomaYang L, Pham K, Yarovinsky T, Defina S, Rose J, Liu C. Virus‐Like Vesicles (VLVs) as Therapeutic Vaccine Vectors for Hepatocellular Carcinoma. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3093.
Abstract 1150: CARG-2020 artificial oncolytic virus delivering three immune-modulators prevents tumor recurrence in a syngeneic model of ovarian cancerAlvero A, Fox A, Madina B, Nakaar V, Yarovinsky T, Krady M, Almassian B, Mor G. Abstract 1150: CARG-2020 artificial oncolytic virus delivering three immune-modulators prevents tumor recurrence in a syngeneic model of ovarian cancer. Cancer Research 2021, 81: 1150-1150. DOI: 10.1158/1538-7445.am2021-1150.
CARG-2020, an oncolytic artificial virus co-delivering three immunomodulators, to regress and cure established tumors in mice.Almassian B, Madina B, Chen J, Krady M, Ma X, Yarovinsky T, Nakaar V, Wang K. CARG-2020, an oncolytic artificial virus co-delivering three immunomodulators, to regress and cure established tumors in mice. Journal Of Clinical Oncology 2021, 39: e14560-e14560. DOI: 10.1200/jco.2021.39.15_suppl.e14560.
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell AxisZhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z, Liu Y, Yarovinsky T, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis. Circulation Research 2020, 127: 855-873. PMID: 32597702, PMCID: PMC7486265, DOI: 10.1161/circresaha.120.316951.
AVIDIO as a novel oncolytic immunotherapy platform for the treatment of colorectal cancer.Almassian B, Madina B, Chen J, Ye X, Krady M, Ma X, Yarovinsky T, Mason S, Nakaar V, Wang K. AVIDIO as a novel oncolytic immunotherapy platform for the treatment of colorectal cancer. Journal Of Clinical Oncology 2020, 38: e15210-e15210. DOI: 10.1200/jco.2020.38.15_suppl.e15210.
Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis BYarovinsky TO, Mason SW, Menon M, Krady MM, Haslip M, Madina BR, Ma X, Moshkani S, Chiale C, Pal AC, Almassian B, Rose JK, Robek MD, Nakaar V. Virus-like Vesicles Expressing Multiple Antigens for Immunotherapy of Chronic Hepatitis B. IScience 2019, 21: 391-402. PMID: 31704650, PMCID: PMC6889364, DOI: 10.1016/j.isci.2019.10.040.
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptorUsselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.
HYPOXIA-INDUCED TRANSLATIONAL PROFILES OF BONE MARROW-DERIVED MACROPHAGES: IMPLICATIONS FOR PROMOTING FAVORABLE TISSUE REPAIR AFTER ISCHEMIAWilcox N, Yarovinsky T, Moro A, Bender J. HYPOXIA-INDUCED TRANSLATIONAL PROFILES OF BONE MARROW-DERIVED MACROPHAGES: IMPLICATIONS FOR PROMOTING FAVORABLE TISSUE REPAIR AFTER ISCHEMIA. Journal Of The American College Of Cardiology 2019, 73: 157. DOI: 10.1016/s0735-1097(19)30765-x.
T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and KRao GK, Wong A, Collinge M, Sarhan J, Yarovinsky TO, Ramgolam VS, Gaestel M, Pardi R, Bender JR. T cell LFA-1-induced proinflammatory mRNA stabilization is mediated by the p38 pathway kinase MK2 in a process regulated by hnRNPs C, H1 and K. PLOS ONE 2018, 13: e0201103. PMID: 30048492, PMCID: PMC6065199, DOI: 10.1371/journal.pone.0201103.
Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque CalcificationCeneri N, Zhao L, Young B, Healy A, Coskun S, Vasavada H, Yarovinsky T, Ike K, Qin L, Pardi R, Meadows J, Tellides G, Hirschi K, Soufer R, Sadeghi M, Bender J, Morrison A. Abstract 655: Rac2 is a Key Modulator of IL-1β -dependent Atherosclerotic Plaque Calcification. Arteriosclerosis Thrombosis And Vascular Biology 2016, 36 DOI: 10.1161/atvb.36.suppl_1.655.
DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosisFathzadeh M, Keramati A, Bazzaz J, Yarovinsky T, Sarajzadeh K, Amini M, Noorafshan A, Mehrabani D, Dianatpour M, Omrani G, Bigi M, Kasaei M, Poustchi H, Lifton R, Malekzadeh R, Mani A. DYRK1B modifies insulin action in liver and skeletal muscle and predispose to atherosclerosis. Atherosclerosis 2015, 241: e23. DOI: 10.1016/j.atherosclerosis.2015.04.093.
Abstract 142: Rac2 Modulates Macrophage IL-1β Production, Atherosclerotic Plaque Inflammation, and Calcific AtherosclerosisCeneri N, Young B, Yarovinsky T, Sadeghi M, Bender J, Morrison A. Abstract 142: Rac2 Modulates Macrophage IL-1β Production, Atherosclerotic Plaque Inflammation, and Calcific Atherosclerosis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.142.
Abstract 429: HuR and microRNA-128 Competitively Regulate Vascular Endothelial Growth Factor C to Modulate Inflammatory LymphangiogenesisYoung B, Zhang J, Mohan A, Robinson N, James L, Ramgolam V, Yarovinsky T, Morrison A, Bender J. Abstract 429: HuR and microRNA-128 Competitively Regulate Vascular Endothelial Growth Factor C to Modulate Inflammatory Lymphangiogenesis. Arteriosclerosis Thrombosis And Vascular Biology 2015, 35 DOI: 10.1161/atvb.35.suppl_1.429.
Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesisMorrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J. Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Journal Of Cell Biology 2014, 206: 2066oia157. DOI: 10.1083/jcb.2066oia157.
Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesisMorrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Journal Of Experimental Medicine 2014, 211: 1957-1968. PMID: 25180062, PMCID: PMC4172219, DOI: 10.1084/jem.20132130.
Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired AngiogenesisMehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis. American Journal Of Pathology 2014, 184: 1562-1576. PMID: 24606881, PMCID: PMC4005977, DOI: 10.1016/j.ajpath.2014.01.009.
Role of phospholipid scramblase 1 in type I interferon-induced protection from staphylococcal α-toxinYarovinsky TO. Role of phospholipid scramblase 1 in type I interferon-induced protection from staphylococcal α-toxin. Virulence 2012, 3: 457-458. PMID: 23076241, PMCID: PMC3485986, DOI: 10.4161/viru.21329.
Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STINGHolm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR. Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nature Immunology 2012, 13: 737-743. PMID: 22706339, PMCID: PMC3411909, DOI: 10.1038/ni.2350.
Abstract 78: Chemokine-Driven β2 Integrin Adhesion Influences Macrophage Cytokine Gene Expression and Atherosclerotic Lesion Composition Through an Induced Rac2-Myosin IIa InteractionMorrison A, Ike K, Yarovinsky T, Bender J. Abstract 78: Chemokine-Driven β2 Integrin Adhesion Influences Macrophage Cytokine Gene Expression and Atherosclerotic Lesion Composition Through an Induced Rac2-Myosin IIa Interaction. Arteriosclerosis Thrombosis And Vascular Biology 2012, 32 DOI: 10.1161/atvb.32.suppl_1.a78.
Th17 cell LFA-1 engagement-mediated IL-17A and GM-CSF mRNA stabilization is HuR-dependent (54.14)Huntenburg S, Ramgolam V, Yarovinsky T, Bender J. Th17 cell LFA-1 engagement-mediated IL-17A and GM-CSF mRNA stabilization is HuR-dependent (54.14). The Journal Of Immunology 2012, 188: 54.14-54.14. DOI: 10.4049/jimmunol.188.supp.54.14.
A conserved AU-rich element in IL-17A mRNA’s 3’-UTR confers posttranscriptional control (59.4)Ramgolam V, Huntenburg S, Yarovinsky T, Bender J. A conserved AU-rich element in IL-17A mRNA’s 3’-UTR confers posttranscriptional control (59.4). The Journal Of Immunology 2012, 188: 59.4-59.4. DOI: 10.4049/jimmunol.188.supp.59.4.
Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory AngiogenesisZhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR. Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis. American Journal Of Pathology 2012, 180: 1751-1760. PMID: 22322302, PMCID: PMC3349897, DOI: 10.1016/j.ajpath.2011.12.025.
Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-ToxinLizak M, Yarovinsky TO. Phospholipid Scramblase 1 Mediates Type I Interferon-Induced Protection against Staphylococcal α-Toxin. Cell Host & Microbe 2012, 11: 70-80. PMID: 22264514, PMCID: PMC3266557, DOI: 10.1016/j.chom.2011.12.004.
Interferons Increase Cell Resistance to Staphylococcal Alpha-Toxin▿Yarovinsky TO, Monick MM, Husmann M, Hunninghake GW. Interferons Increase Cell Resistance to Staphylococcal Alpha-Toxin▿. Infection And Immunity 2007, 76: 571-577. PMID: 18070901, PMCID: PMC2223481, DOI: 10.1128/iai.01088-07.
Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuRYarovinsky TO, Butler NS, Monick MM, Hunninghake GW. Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuR. The Journal Of Immunology 2006, 177: 4426-4435. PMID: 16982877, DOI: 10.4049/jimmunol.177.7.4426.
SEVERE SEPSIS IS ASSOCIATED WITH AN APOPTOSIS-MEDIATED DECREASE IN HEPATIC BACTERIAL CLEARANCEAshare A, Yarovinsky T, Monick M, Hunninghake G. SEVERE SEPSIS IS ASSOCIATED WITH AN APOPTOSIS-MEDIATED DECREASE IN HEPATIC BACTERIAL CLEARANCE. CHEST Journal 2005, 128: 379s-1-379s-2. DOI: 10.1378/chest.128.4_meetingabstracts.379s.
Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral InfectionYarovinsky TO, Mohning MP, Bradford MA, Monick MM, Hunninghake GW. Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection. Infection And Immunity 2005, 73: 3375-3384. PMID: 15908364, PMCID: PMC1111844, DOI: 10.1128/iai.73.6.3375-3384.2005.
Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanismsYarovinsky T, Hunninghake G. Lung fibroblasts inhibit activation-induced death of T cells through PGE2-dependent mechanisms. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2001, 281: l1248-l1256. PMID: 11597917, DOI: 10.1152/ajplung.2001.281.5.l1248.
Application of DNA Topoisomerase-Activated Adapters to Riboprobe SynthesisYarovinsky T. Application of DNA Topoisomerase-Activated Adapters to Riboprobe Synthesis. BioTechniques 2000, 28: 1160-1165. PMID: 10868281, DOI: 10.2144/00286st06.
Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptorsYarovinsky T, Rickman D, Diamond R, Taub R, Hageman G, Rickman C. Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. Brain Research 2000, 77: 95-103. PMID: 10814835, DOI: 10.1016/s0169-328x(00)00045-0.
α2-macroglobulin enhances fibroblast adhesiveness for T lymphocytesGorlina N, Yarovinsky T, Zorin N, Veselova A, Pavlyuk A, Cheredeev A. α2-macroglobulin enhances fibroblast adhesiveness for T lymphocytes. Immunology Letters 1997, 56: 255-256. DOI: 10.1016/s0165-2478(97)86020-8.
Pretreatment of fibroblasts with α2M changes their morphology affected by lymphocytesYarovinsky T, Gorlina N, Zorin N, Zorina R, Larin S, Cheredeev A. Pretreatment of fibroblasts with α2M changes their morphology affected by lymphocytes. Immunology Letters 1997, 56: 255. DOI: 10.1016/s0165-2478(97)86019-1.

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