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Janitza Montalvo-Ortiz, PhD

Assistant Professor of Psychiatry

Research & Publications
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Selected Publications

Neuronal-Specific Methylome and Hydroxymethylome Analysis Reveal Replicated and Novel Loci Associated With Alcohol Use DisorderAndrade-Brito D, Nunez-Rios D, Martinez-Magaña J, Rompala G, Zillich L, Witt S, Clark S, Group T, Group P, Montalvo-Ortiz J. Neuronal-Specific Methylome and Hydroxymethylome Analysis Reveal Replicated and Novel Loci Associated With Alcohol Use Disorder. Biological Psychiatry 2024, 95: s19-s20. DOI: 10.1016/j.biopsych.2024.02.052.
Epigenome-Wide Meta-Analysis of 11 Military and Civilian Cohorts Reveals Cell-Type Specific and Inflammatory DNA Methylation Patterns Associated With PTSDKatrinli S, Wani A, Zhao X, Maihofer A, Zhao Y, Nunez D, Montalvo-Ortiz J, Zannas A, Logue M, Nievergelt C, Uddin M, Smith A, Workgroup P. Epigenome-Wide Meta-Analysis of 11 Military and Civilian Cohorts Reveals Cell-Type Specific and Inflammatory DNA Methylation Patterns Associated With PTSD. Biological Psychiatry 2024, 95: s33. DOI: 10.1016/j.biopsych.2024.02.085.
Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress DisorderNunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.
The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid MisuseMartinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individualsJennings M, Martínez-Magaña J, Courchesne-Krak N, Cupertino R, Vilar-Ribó L, Bianchi S, Hatoum A, Atkinson E, Giusti-Rodriguez P, Montalvo-Ortiz J, Gelernter J, Artigas M, 23andMe I, Aslibekyan S, Auton A, Babalola E, Bell R, Bielenberg J, Bryc K, Bullis E, Coker D, Partida G, Dhamija D, Das S, Elson S, Eriksson N, Filshtein T, Fitch A, Fletez-Brant K, Fontanillas P, Freyman W, Granka J, Heilbron K, Hernandez A, Hicks B, Hinds D, Jewett E, Jiang Y, Kukar K, Kwong A, Lin K, Llamas B, Lowe M, McCreight J, McIntyre M, Micheletti S, Moreno M, Nandakumar P, Nguyen D, Noblin E, O'Connell J, Petrakovitz A, Poznik G, Reynoso A, Schumacher M, Shastri A, Shelton J, Shi J, Shringarpure S, Su Q, Tat S, Tchakouté C, Tran V, Tung J, Wang X, Wang W, Weldon C, Wilton P, Wong C, Elson S, Edenberg H, Fontanillas P, Palmer A, Sanchez-Roige S. A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. EBioMedicine 2024, 103: 105086. PMID: 38580523, PMCID: PMC11121167, DOI: 10.1016/j.ebiom.2024.105086.
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorderAndrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.
Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAgeTamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAgeTamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
25. EPIGENOME-WIDE META-ANALYSIS OF > 3200 MILITARY AND CIVILIAN PARTICIPANTS IDENTIFIES CELL-TYPE SPECIFIC DNA METHYLATION SIGNALS ASSOCIATED WITH PTSDKatrinli S, Wani A, Zhao X, Maihofer A, Zhao Y, Nunez D, Montalvo-Ortiz J, Zannas A, Logue M, Nievergelt C, Uddin M, Smith A, Group P. 25. EPIGENOME-WIDE META-ANALYSIS OF > 3200 MILITARY AND CIVILIAN PARTICIPANTS IDENTIFIES CELL-TYPE SPECIFIC DNA METHYLATION SIGNALS ASSOCIATED WITH PTSD. European Neuropsychopharmacology 2023, 75: s70-s71. DOI: 10.1016/j.euroneuro.2023.08.136.
W101. EPIGENETIC PROFILES OF LATENT CLASSES FOR POLYSUBSTANCE USE DISORDERPathak G, Pietrzak R, Levey D, Montalvo-Ortiz J, Kranzler H, Gelernter J, Polimanti R. W101. EPIGENETIC PROFILES OF LATENT CLASSES FOR POLYSUBSTANCE USE DISORDER. European Neuropsychopharmacology 2023, 75: s158-s159. DOI: 10.1016/j.euroneuro.2023.08.287.
21. ADVANCING THE UNDERSTANDING OF DEPRESSION GENETICS: AN INTRODUCTION TO THE MAJOR DEPRESSION WORKING GROUP OF THE LATIN AMERICAN GENOMICS CONSORTIUM.Corral-Frias N, Nunez D, Ota V, Cárcamo J, Machado C, Amaya L, Toledo M, Nagamatsu S, Group L, Dunn E, Torres-Hernández B, Lattig C, Giusti-Rodriguez P, Montalvo-Ortiz J, Peterson R. 21. ADVANCING THE UNDERSTANDING OF DEPRESSION GENETICS: AN INTRODUCTION TO THE MAJOR DEPRESSION WORKING GROUP OF THE LATIN AMERICAN GENOMICS CONSORTIUM. European Neuropsychopharmacology 2023, 75: s68. DOI: 10.1016/j.euroneuro.2023.08.132.
Importance of including individuals of Latin American ancestry in genetic studies of feeding and eating disordersMurgueito J, Martínez-Magaña J, Trujillo-Chi Vacuan E, Cortes-Morales S, Compte E, Storch E, Camarena B, Muniz Carvahlo C, Peterson R, Belangero S, Montalvo-Ortiz J, Atkinson E, Giusti-Rodríguez P, Genomics Consortium L, Bulik C. Importance of including individuals of Latin American ancestry in genetic studies of feeding and eating disorders. Psicologia 2023, 34: 262-283. DOI: 10.55611/reps.3402.10.
Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort studyNa P, Zhou H, Montalvo-Ortiz J, Cabrera-Mendoza B, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study. Psychological Medicine 2023, 53: 7893-7901. PMID: 37642191, DOI: 10.1017/s003329172300199x.
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortexRompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.
CpG and Non-CpG Epigenomic Analyses in Orbitofrontal Neurons Reveal Hydroxymethylation as an Important Regulatory Mechanism in PTSDMontalvo-Ortiz J, Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martínez-Magaña J, Krystal J. CpG and Non-CpG Epigenomic Analyses in Orbitofrontal Neurons Reveal Hydroxymethylation as an Important Regulatory Mechanism in PTSD. Biological Psychiatry 2023, 93: s68. DOI: 10.1016/j.biopsych.2023.02.183.
Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal studyNa P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.
Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic ReviewNúñez-Rios D, Martínez-Magaña J, Nagamatsu S, Krystal J, Martínez-González K, Giusti-Rodríguez P, Montalvo-Ortiz J. Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review. Complex Psychiatry 2023, 9: 100-118. PMID: 37404872, PMCID: PMC10315001, DOI: 10.1159/000529536.
CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorderNagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.
Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s diseaseRodriguez G, Fisher D, McClarty B, Montalvo-Ortiz J, Cui Q, Chan C, Dong H. Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease. Frontiers In Psychiatry 2023, 13: 1020831. PMID: 36684015, PMCID: PMC9852991, DOI: 10.3389/fpsyt.2022.1020831.
Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohortNagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
NEURONAL-SPECIFIC METHYLOME AND HYDROXYMETHYLOME ANALYSIS IDENTIFIES NOVEL LOCI ASSOCIATED WITH ALCOHOL USE DISORDERAndrade-Brito D, Núñez-Ríos D, Hurd Y, Rompala G, Montalvo-Ortiz J. NEURONAL-SPECIFIC METHYLOME AND HYDROXYMETHYLOME ANALYSIS IDENTIFIES NOVEL LOCI ASSOCIATED WITH ALCOHOL USE DISORDER. European Neuropsychopharmacology 2022, 63: e132. DOI: 10.1016/j.euroneuro.2022.07.245.
48. GENOME-WIDE ASSOCIATION STUDY OF ALCOHOL CONSUMPTION IDENTIFIES NOVEL LOCI IN LATIN AMERICAN POPULATIONS: FINDINGS FROM THE LATIN AMERICAN GENOMICS CONSORTIUMMartinez-Magana J, Brito D, Kember R, Kranzler H, Gelenter J, Wassertheil-Smoller S, Perreira K, Daviglus M, Nicolini H, Belangero S, Tucker K, Ordovas J, Atkinson E, Giusti-Rodríguez P, Montalvo-Ortiz J. 48. GENOME-WIDE ASSOCIATION STUDY OF ALCOHOL CONSUMPTION IDENTIFIES NOVEL LOCI IN LATIN AMERICAN POPULATIONS: FINDINGS FROM THE LATIN AMERICAN GENOMICS CONSORTIUM. European Neuropsychopharmacology 2022, 63: e71. DOI: 10.1016/j.euroneuro.2022.07.136.
NON-CPG METHYLOME ANALYSIS IN HUMAN CORTICAL NEURONS IDENTIFIES NOVEL GENE PATHWAYS AND DRUG TARGETS FOR OPIOID USE DISORDERNagamatsu S, Rompala G, Hurd Y, Nunez D, Group T, Montalvo-Ortiz J. NON-CPG METHYLOME ANALYSIS IN HUMAN CORTICAL NEURONS IDENTIFIES NOVEL GENE PATHWAYS AND DRUG TARGETS FOR OPIOID USE DISORDER. European Neuropsychopharmacology 2022, 63: e273. DOI: 10.1016/j.euroneuro.2022.07.486.
T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSDNunez D, Rompala G, Hurd Y, Nagamatsu S, Martínez-Magaña J, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. T69. CPG AND NON-CPG EPIGENOMIC MAPPING IN HUMAN CORTICAL NEURONS REVEALS HYDROXYMETHYLATION AS AN IMPORTANT GENE REGULATORY MECHANISM IN PTSD. European Neuropsychopharmacology 2022, 63: e205-e206. DOI: 10.1016/j.euroneuro.2022.07.369.
Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military VeteransTamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial Factors Associated With Accelerated GrimAge in Male U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2022, 31: 97-109. PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.
Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35802930, PMCID: PMC10859885, DOI: 10.4088/jcp.21br14309.
Cross-ancestry genomic research: time to close the gapAtkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. Cross-ancestry genomic research: time to close the gap. Neuropsychopharmacology 2022, 47: 1737-1738. PMID: 35739257, PMCID: PMC9372026, DOI: 10.1038/s41386-022-01365-7.
Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics EvidenceNúñez-Rios DL, Martínez-Magaña JJ, Nagamatsu ST, Andrade-Brito DE, Forero DA, Orozco-Castaño CA, Montalvo-Ortiz JL. Central and Peripheral Immune Dysregulation in Posttraumatic Stress Disorder: Convergent Multi-Omics Evidence. Biomedicines 2022, 10: 1107. PMID: 35625844, PMCID: PMC9138536, DOI: 10.3390/biomedicines10051107.
P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military VeteransNagamatsu S, Pietrzak R, Na P, Krystal J, Gelernter J, Montalvo-Ortiz J. P79. Are Positive Psychosocial Traits Linked to Epigenetic Aging? Results From a National Sample of U.S. Military Veterans. Biological Psychiatry 2022, 91: s119. DOI: 10.1016/j.biopsych.2022.02.313.
The role of alcohol intake in the pharmacogenetics of treatment with clozapineMonroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M. The role of alcohol intake in the pharmacogenetics of treatment with clozapine. Pharmacogenomics 2022, 23: 371-392. PMID: 35311547, DOI: 10.2217/pgs-2022-0006.
Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veteransMontalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans. Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
Chapter 11 Epigenomic biomarkers of posttraumatic stress disorderMontalvo-Ortiz J. Chapter 11 Epigenomic biomarkers of posttraumatic stress disorder. 2022, 163-177. DOI: 10.1016/b978-0-12-823039-8.00020-4.
TH13. AN IN SILICO ANALYSIS OF GENOME-WIDE EXPRESSION AND METHYLATION PROFILES FROM HUMAN AND MOUSE MODELS OF POST-TRAUMATIC STRESS DISORDER IDENTIFY ALTERATIONS IN BRAIN-PLASTICITY MECHANISMSOrozco C, González-Giraldo Y, Bonilla D, Montalvo-Ortiz J, Forero D. TH13. AN IN SILICO ANALYSIS OF GENOME-WIDE EXPRESSION AND METHYLATION PROFILES FROM HUMAN AND MOUSE MODELS OF POST-TRAUMATIC STRESS DISORDER IDENTIFY ALTERATIONS IN BRAIN-PLASTICITY MECHANISMS. European Neuropsychopharmacology 2021, 51: e201-e202. DOI: 10.1016/j.euroneuro.2021.08.188.
LATIN AMERICAN GENOMICS CONSORTIUM: AN INTRODUCTIONMontalvo-Ortiz J. LATIN AMERICAN GENOMICS CONSORTIUM: AN INTRODUCTION. European Neuropsychopharmacology 2021, 51: e16. DOI: 10.1016/j.euroneuro.2021.07.041.
ADVANCING PSYCHIATRIC GENETICS RESEARCH IN LATINX POPULATIONS: CONSORTIUM EFFORTS AND BEYONDGiusti-Rodriguez P, Montalvo-Ortiz J, Atkinson E. ADVANCING PSYCHIATRIC GENETICS RESEARCH IN LATINX POPULATIONS: CONSORTIUM EFFORTS AND BEYOND. European Neuropsychopharmacology 2021, 51: e16. DOI: 10.1016/j.euroneuro.2021.07.040.
14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEXRompala G, Nagamatsu S, Hurd Y, Krystal J, Gelernter J, Group T, Montalvo-Ortiz J. 14. PROFILING NEUROEPIGENOMIC NETWORKS OF OPIOID USE DISORDER IN HUMAN ORBITOFRONTAL CORTEX. European Neuropsychopharmacology 2021, 51: e47-e48. DOI: 10.1016/j.euroneuro.2021.07.106.
DNA methylation changes in African American women with a history of preterm birth from the InterGEN studyBarcelona V, Montalvo-Ortiz JL, Wright ML, Nagamatsu ST, Dreisbach C, Crusto CA, Sun YV, Taylor JY. DNA methylation changes in African American women with a history of preterm birth from the InterGEN study. BMC Genomic Data 2021, 22: 30. PMID: 34482817, PMCID: PMC8418749, DOI: 10.1186/s12863-021-00988-x.
Differential Methylation and Co-Methylation Analysis Reveals Functional Targets of Major Depressive Disorder in WomenMontalvo-Ortiz J, Nagamatsu S, Cheng Z, Kranzler H, Gelernter J. Differential Methylation and Co-Methylation Analysis Reveals Functional Targets of Major Depressive Disorder in Women. Biological Psychiatry 2021, 89: s382. DOI: 10.1016/j.biopsych.2021.02.949.
The Role of 5-HT2B Receptor on Aggression and Drugs of AbuseMontalvo-Ortiz J, Coccaro E. The Role of 5-HT2B Receptor on Aggression and Drugs of Abuse. 2021, 35: 291-307. DOI: 10.1007/978-3-030-55920-5_17.
Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans StudyTamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study. Biological Psychiatry 2020, 89: 878-887. PMID: 33276944, DOI: 10.1016/j.biopsych.2020.09.018.
Advancing Alcohol Genetics Research: One Genome-wide Association Study at a Time and BeyondMontalvo-Ortiz JL. Advancing Alcohol Genetics Research: One Genome-wide Association Study at a Time and Beyond. Biological Psychiatry 2020, 87: 590-591. PMID: 32164913, DOI: 10.1016/j.biopsych.2020.01.003.
Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated childrende Araújo CM, Hudziak J, Crocetti D, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff RR, O'Loughlin K, Holbrook H, Garavan H, Yang BZ, Mostofsky S, Jackowski A, Lee RS, Gelernter J, Kaufman J. Tubulin Polymerization Promoting Protein (TPPP) gene methylation and corpus callosum measures in maltreated children. Psychiatry Research Neuroimaging 2020, 298: 111058. PMID: 32120304, PMCID: PMC11079625, DOI: 10.1016/j.pscychresns.2020.111058.
Social supports moderate the effects of child adversity on neural correlates of threat processingWymbs NF, Orr C, Albaugh MD, Althoff RR, O’Loughlin K, Holbrook H, Garavan H, Montalvo-Ortiz JL, Mostofsky S, Hudziak J, Kaufman J. Social supports moderate the effects of child adversity on neural correlates of threat processing. Child Abuse & Neglect 2020, 102: 104413. PMID: 32065988, PMCID: PMC8060780, DOI: 10.1016/j.chiabu.2020.104413.
Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American WomenMontalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Author Correction: Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. Scientific Reports 2019, 9: 18774. PMID: 31801960, PMCID: PMC6892860, DOI: 10.1038/s41598-019-55022-z.
Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male VeteransXu K, Montalvo‐Ortiz J, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans. Alcohol Clinical And Experimental Research 2019, 43: 2111-2121. PMID: 31386212, PMCID: PMC9377208, DOI: 10.1111/acer.14168.
131. OTX2, Child Abuse, and PsychosisMontalvo-Ortiz J, Hudziak J, Wymbs N, Orr C, Albaugh M, Althoff R, O'Loughlin K, Holbrook H, Garavan H, Mostofsky S, Gelernter J, Kaufman J. 131. OTX2, Child Abuse, and Psychosis. Biological Psychiatry 2019, 85: s54-s55. DOI: 10.1016/j.biopsych.2019.03.145.
58. Child Abuse, Depression, and Methylation in Myelin-Related GenesKaufman J, Montalvo-Ortiz J, Wymbs N, Orr C, Albaugh M, O'Loughlkin K, Holbrook H, Althoff R, Garavan H, Mostofsky S, Gelernter J, Hudziak J. 58. Child Abuse, Depression, and Methylation in Myelin-Related Genes. Biological Psychiatry 2019, 85: s24-s25. DOI: 10.1016/j.biopsych.2019.03.072.
26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. VeteransMontalvo-Ortiz J, Gelernter J, Southwick S, Krystal J, Pietrzak R. 26. Epigenome-Wide Association Study of Posttraumatic Stress Symptoms in 1,135 U.S. Veterans. Biological Psychiatry 2019, 85: s11. DOI: 10.1016/j.biopsych.2019.03.040.
Understanding risk and resilience in maltreated childrenKaufman J, Montalvo-Ortiz J, Lee R. Understanding risk and resilience in maltreated children. 2019, 304-323. DOI: 10.1093/oso/9780198793014.003.0021.
Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American WomenMontalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women. Scientific Reports 2019, 9: 4660. PMID: 30874594, PMCID: PMC6420601, DOI: 10.1038/s41598-019-41110-7.
Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans StudyTamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.
M79 GENOME-WIDE DNA METHYLATION SIGNATURES OF AGGRESSION RISK IN CHILDRENMontalvo-Ortiz J, Hudziak J, Holbrook H, O'Loughlin K, Gelernter J, Kaufman J. M79 GENOME-WIDE DNA METHYLATION SIGNATURES OF AGGRESSION RISK IN CHILDREN. European Neuropsychopharmacology 2019, 29: s997-s998. DOI: 10.1016/j.euroneuro.2017.08.386.
Adverse Childhood Experiences, Epigenetic Measures, and Obesity in YouthKaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth. The Journal Of Pediatrics 2018, 202: 150-156.e3. PMID: 30177354, PMCID: PMC6513669, DOI: 10.1016/j.jpeds.2018.06.051.
Methylation in OTX2 and related genes, maltreatment, and depression in childrenKaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O’Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Methylation in OTX2 and related genes, maltreatment, and depression in children. Neuropsychopharmacology 2018, 43: 2204-2211. PMID: 30089883, PMCID: PMC6135753, DOI: 10.1038/s41386-018-0157-y.
Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis responseMontalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular Psychiatry 2018, 23: 2277-2286. PMID: 29875475, PMCID: PMC6281782, DOI: 10.1038/s41380-018-0077-6.
20. Child Abuse and Epigenetic Mechanisms of Disease RiskMontalvo-Ortiz J, Gelernter J, Wymbs N, Althoff R, Hudziak J, Zhao H, Kaufman J. 20. Child Abuse and Epigenetic Mechanisms of Disease Risk. Biological Psychiatry 2018, 83: s8. DOI: 10.1016/j.biopsych.2018.02.037.
F123. Genome-Wide Epigenetic Signatures of Major Depressive Disorder in WomenMontalvo-Ortiz J, Kranzler H, Zhao H, Zhang H, Gelernter J. F123. Genome-Wide Epigenetic Signatures of Major Depressive Disorder in Women. Biological Psychiatry 2018, 83: s285. DOI: 10.1016/j.biopsych.2018.02.736.
Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged ratsDong H, Keegan JM, Hong E, Gallardo C, Montalvo-Ortiz J, Wang B, Rice KC, Csernansky J. Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats. Psychoneuroendocrinology 2018, 90: 92-101. PMID: 29477954, PMCID: PMC5864558, DOI: 10.1016/j.psyneuen.2018.02.013.
Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment AnalysisMontalvo-Ortiz JL, Zhang H, Chen C, Liu C, Coccaro EF. Genome-Wide DNA Methylation Changes Associated with Intermittent Explosive Disorder: A Gene-Based Functional Enrichment Analysis. The International Journal Of Neuropsychopharmacology 2017, 21: 12-20. PMID: 29106553, PMCID: PMC5789263, DOI: 10.1093/ijnp/pyx087.
A New Perspective on the Mechanisms of NeglectMontalvo-Ortiz JL. A New Perspective on the Mechanisms of Neglect. Biological Psychiatry 2017, 82: e49-e50. PMID: 28870299, DOI: 10.1016/j.biopsych.2017.07.013.
908 Genome-Wide Association Study Identifies HTR2B as a Risk Variant of Cannabis-Related Aggression in African AmericansMontalvo-Ortiz J, Zhou H, Farrer L, Kranzler H, Gelernter J. 908 Genome-Wide Association Study Identifies HTR2B as a Risk Variant of Cannabis-Related Aggression in African Americans. Biological Psychiatry 2017, 81: s367. DOI: 10.1016/j.biopsych.2017.02.634.
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in miceMontalvo-Ortiz JL, Fisher DW, Rodríguez G, Fang D, Csernansky JG, Dong H. Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. Psychopharmacology 2017, 234: 2385-2398. PMID: 28421257, PMCID: PMC5538925, DOI: 10.1007/s00213-017-4629-2.
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglectMontalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.
RDoC and translational perspectives on the genetics of trauma‐related psychiatric disordersMontalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 171: 81-91. PMID: 26592203, PMCID: PMC4754782, DOI: 10.1002/ajmg.b.32395.
Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological SubstratesVarghese SP, Montalvo-Ortiz JL, Csernansky JG, Eiger RI, Herrold AA, Koola MM, Dong H. Early Life Stress as a Risk Factor for Substance use Disorders: Clinical and Neurobiological Substrates. Indian Journal Of Psychological Medicine 2015, 37: 36-41. PMID: 25722510, PMCID: PMC4341308, DOI: 10.4103/0253-7176.150816.
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 miceDong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology 2014, 231: 4711-4722. PMID: 24862368, PMCID: PMC4233002, DOI: 10.1007/s00213-014-3629-8.
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone AcetylationMontalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation. Neuropsychopharmacology 2013, 39: 1469-1478. PMID: 24366052, PMCID: PMC3988551, DOI: 10.1038/npp.2013.346.
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's DiseaseDong H, Murphy KM, Meng L, Montalvo-Ortiz J, Zeng Z, Kolber BJ, Zhang S, Muglia LJ, Csernansky JG. Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 28: 579-592. PMID: 22045495, PMCID: PMC3494090, DOI: 10.3233/jad-2011-111328.
Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female ratsLevin ED, Perkins A, Brotherton T, Qazi M, Berez C, Montalvo-Ortiz J, Davis K, Williams P, Christopher NC. Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2008, 33: 296-302. PMID: 19146909, PMCID: PMC2684503, DOI: 10.1016/j.pnpbp.2008.12.003.

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