Sheila Nagamatsu, PhD
DownloadHi-Res Photo
About
Titles
Postdoctoral Associate
Biography
As a postdoctoral associate at Yale University, I specialize in psychiatry genetics research. My primary focus is on epigenomic-wide association studies of various conditions, including smoking, opioid addiction, depression, and PTSD. I earned my Ph.D. in genetics and molecular biology from the University of Campinas in Brazil, where I focused on the bioinformatics of industrial yeasts and their application to bioethanol production.
Education & Training
- PhD
- University of Campinas, Genetics and Molecular Biology, Bioinformatics (2019)
- Internship
- Senai Institute of Innovation in Biomass (ISI BIOMASSA) (2015)
- BSc
- Federal University of São Carlos, Biotechnology (2013)
- Internship
- University of Campinas (2013)
- Internship
- University of the Basque Country (2013)
- President and Founder Member
- Federal University of São Carlos (UFSCar)/ CSB Júnior
- Non Degree Program
- Colégio Policursos, Technical School in Microcomputer Operator (2004)
Research
Overview
Medical Subject Headings (MeSH)
Biological Evolution; Genetic Background; Mutagenesis; Psychiatry and Psychology; Saccharomyces cerevisiae
ORCID
0000-0002-4986-5094
Research at a Glance
Yale Co-Authors
Frequent collaborators of Sheila Nagamatsu's published research.
Publications Timeline
A big-picture view of Sheila Nagamatsu's research output by year.
Research Interests
Research topics Sheila Nagamatsu is interested in exploring.
Janitza Montalvo-Ortiz, PhD
John Krystal, MD
Joel Gelernter, MD
Brenda Cabrera-Mendoza, MD/PhD
Chadi Abdallah, MD
José Jaime Martínez-Magaña, BSc, MSc, PhD
28Publications
257Citations
Saccharomyces cerevisiae
Publications
2024
ONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES.
SCARINI J, NAGAMATSU S, CARAZZOLLE M, Abu EGAL É, ALTEMANI A, CASTILHO R, MARIANO F. ONCOGENES AND TUMOR SUPPRESSOR GENES IN CARCINOMA EX PLEOMORPHIC ADENOMA DEVELOPMENT: OLD FACTS AND NEW HYPOTHESES. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2024, 137: e303. DOI: 10.1016/j.oooo.2023.12.719.Peer-Reviewed Original ResearchConceptsTumor suppressor geneWhole-exome sequencingSingle nucleotide variantsGenetic alterationsAllele frequenciesSuppressor geneHg38 reference genomeDisease allele frequencyReference genomeSequence readsNucleotide variantsExome sequencingDNA samplesMYBOncogenic activityPublic databasesPleomorphic adenomaGenesOncogenePre-existing pleomorphic adenomaPotential involvementSequenceTP53Background CarcinomaRare tumorThe Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse
Martinez-Magaña J, Nagamatsu S, Nunez-Rios D, Krystal J, Girgenti M, Group T, Montalvo-Ortiz J. The Prefrontal Cortex Transcriptomic Landscape of the Comorbidity Between Post-Traumatic Stress Disorder and Opioid Misuse. Biological Psychiatry 2024, 95: s69. DOI: 10.1016/j.biopsych.2024.02.169.Peer-Reviewed Original ResearchMulti-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder
Nunez-Rios D, Hurd Y, Rompala G, Nagamatsu S, Martinez-Magaña J, Krystal J, Group T, Montalvo-Ortiz J. Multi-Omics Mapping in Human Cortical Neurons Reveals Well-Known and Novel Loci of Post-Traumatic Stress Disorder. Biological Psychiatry 2024, 95: s34. DOI: 10.1016/j.biopsych.2024.02.087.Peer-Reviewed Original ResearchNeuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder
Andrade-Brito D, Núñez-Ríos D, Martínez-Magaña J, Nagamatsu S, Rompala G, Zillich L, Witt S, Clark S, Lattig M, Montalvo-Ortiz J, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Keane T, Krystal J, Labadorf A, Logue M, Marx B, Mash D, McKee A, Miller M, Montalvo-Ortiz J, Noller C, Schnurr P, Scott W, Stein T, Ursano R, Williamson D, Wolf E, Young K. Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder. Frontiers In Genetics 2024, 15: 1345410. PMID: 38633406, PMCID: PMC11021708, DOI: 10.3389/fgene.2024.1345410.Peer-Reviewed Original ResearchConceptsAssociated with alcohol use disorderAlcohol use disorderOrbitofrontal cortexEpigenome-wide association studiesUse disorderStudy of alcohol use disorderHuman orbitofrontal cortexAlcohol-related traitsHuman brainPostmortem brain samplesHuman postmortem brain samplesEnrichment analysisDifferential CpG sitesPostmortem brain tissueGenome-wide levelOxidative bisulfite sequencingAssessed 5Functional enrichment analysisBrain tissueFalse discovery rateBisulfite sequencingAssociation studiesDifferential methylationIdentified genesDNA methylationCorrection: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Correction: Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2024, 49: 764-764. PMID: 38182778, PMCID: PMC10876612, DOI: 10.1038/s41386-023-01786-y.Peer-Reviewed Original Research
2023
Know-how of holding a Bioinformatics competition: Structure, model, overview, and perspectives
Horácio E, de Carvalho L, Pereira G, Abrahim M, Coelho M, De Jesus D, García G, de Melo-Minardi R, Nagamatsu S. Know-how of holding a Bioinformatics competition: Structure, model, overview, and perspectives. PLOS Computational Biology 2023, 19: e1011679. PMID: 38127831, PMCID: PMC10735175, DOI: 10.1371/journal.pcbi.1011679.Peer-Reviewed Original ResearchAltmetricMeSH KeywordsPsychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.Peer-Reviewed Original ResearchAltmetricConceptsPolygenic risk scoresRisk scoreGenetic predispositionModifiable psychosocial variablesAge-related morbidityGamma-glutamyl transferaseInflammatory biomarkersSystemic inflammationNational HealthApolipoprotein BMale veteransPsychosocial factorsVeterans StudySaliva samplesPsychosocial moderatorsPsychosocial variablesAntihistamine drugsMilitary veteransGrimAgeGrimAge accelerationInflammationUK BiobankDrugsRepresentative samplePredispositionProfiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOpioid use disorderMulti-omics findingsGene expression patternsCo-methylation analysisGene expression profilesMulti-omics profilingGene networksDNA methylationNeuronal methylomesDNA hydroxymethylationMethylomic analysisExpression patternsExpression profilesEpigenetic disturbancesUse disordersPsychiatric traitsOrbitofrontal cortexOpioid-related drugsPostmortem orbitofrontal cortexEnvironmental factorsDrug interaction analysisOUD treatmentHuman orbitofrontal cortexOpioid signalingInteraction analysisCpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder
Nagamatsu S, Rompala G, Hurd Y, Núñez-Rios D, Montalvo-Ortiz J, Group T, Alvarez V, Benedek D, Che A, Cruz D, Davis D, Girgenti M, Hoffman E, Holtzheimer P, Huber B, Kaye A, Krystal J, Labadorf A, Keane T, Logue M, McKee A, Marx B, Mash D, Miller M, Noller C, JM-O, Scott W, Schnurr P, Stein T, Ursano R, Williamson D, Wolf E, Young K. CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder. Frontiers In Psychiatry 2023, 13: 1078894. PMID: 36745154, PMCID: PMC9892724, DOI: 10.3389/fpsyt.2022.1078894.Peer-Reviewed Original ResearchCitationsAltmetricConceptsOpioid use disorderOrbital frontal cortexDNA methylationKEGG enrichment analysisUse disordersMCPH lociTreatment of OUDGene OntologyEnrichment analysisOpioid-related drugsCpG sitesDrug targetsOxidative bisulfite sequencingImportant biological pathwaysDrug interaction analysisDrug-gene interaction databaseNervous system developmentSmoking statusBrain BankCortical neuronsFrontal cortexNeuronal nucleiHuman studiesGene regulationMethylome analysis
2022
Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort
Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSmoking statusNicotine dependenceVeteran cohortNon-current smokersSerious public health issueNovel treatment strategiesPublic health issueUS military veteransEpigenome-wide association studiesCurrent smokersTreatment strategiesFagerström TestNicotine addictionSmokingHealth issuesRole of epigeneticsMilitary veteransMethylationEPIC BeadChip arraySmokersContinuous variablesF2RL3 geneCohortBiomarkersBeadChip arrayPrevious findings
Academic Achievements and Community Involvement
activity Reviewer
Journal ServiceFrontiers in PsychiatryDetails2023 - Presentactivity Reviewer
Journal ServiceFrontiers in GeneticsDetails02/02/2023 - Presenthonor Best Poster at 4th Annual Postdoc Symposium
Yale University AwardYale Postdoc SymposiumDetails06/17/2021United Stateshonor SHARP Training Scholarship Awards for Trainees and Career Development
National AwardThe SHARP Scholarship CommitteeDetails03/31/2021United Stateshonor Oral Finalist at the World Congress of Psychiatric Genetics
Other AwardWCPGDetails10/16/2020United States
Links & Media
News
Related Links
Get In Touch
Contacts
Mailing Address
Montalvo-Ortiz Lab
Errera Community Care Center-Orange Annex, 200 Edison Road, room 1342-22.
Orange, CT 06477
United States