Chadi Abdallah, MD
Associate Professor Adjunct of Psychiatry; Deputy Director for Research, and Director of Neuroimaging, Clinical Neuroscience Division, VA National Center for PTSD
Research & Publications
Biography
News
Coauthors
Selected Publications
- Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methodsYang J, Huggins A, Sun D, Baird C, Haswell C, Frijling J, Olff M, van Zuiden M, Koch S, Nawijn L, Veltman D, Suarez-Jimenez B, Zhu X, Neria Y, Hudson A, Mueller S, Baker J, Lebois L, Kaufman M, Qi R, Lu G, Říha P, Rektor I, Dennis E, Ching C, Thomopoulos S, Salminen L, Jahanshad N, Thompson P, Stein D, Koopowitz S, Ipser J, Seedat S, du Plessis S, van den Heuvel L, Wang L, Zhu Y, Li G, Sierk A, Manthey A, Walter H, Daniels J, Schmahl C, Herzog J, Liberzon I, King A, Angstadt M, Davenport N, Sponheim S, Disner S, Straube T, Hofmann D, Grupe D, Nitschke J, Davidson R, Larson C, deRoon-Cassini T, Blackford J, Olatunji B, Gordon E, May G, Nelson S, Abdallah C, Levy I, Harpaz-Rotem I, Krystal J, Morey R, Sotiras A. Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods. Neuropsychopharmacology 2023, 49: 609-619. PMID: 38017161, PMCID: PMC10789873, DOI: 10.1038/s41386-023-01763-5.
- Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortiumZhu X, Kim Y, Ravid O, He X, Suarez-Jimenez B, Zilcha-Mano S, Lazarov A, Lee S, Abdallah C, Angstadt M, Averill C, Baird C, Baugh L, Blackford J, Bomyea J, Bruce S, Bryant R, Cao Z, Choi K, Cisler J, Cotton A, Daniels J, Davenport N, Davidson R, DeBellis M, Dennis E, Densmore M, deRoon-Cassini T, Disner S, Hage W, Etkin A, Fani N, Fercho K, Fitzgerald J, Forster G, Frijling J, Geuze E, Gonenc A, Gordon E, Gruber S, Grupe D, Guenette J, Haswell C, Herringa R, Herzog J, Hofmann D, Hosseini B, Hudson A, Huggins A, Ipser J, Jahanshad N, Jia-Richards M, Jovanovic T, Kaufman M, Kennis M, King A, Kinzel P, Koch S, Koerte I, Koopowitz S, Korgaonkar M, Krystal J, Lanius R, Larson C, Lebois L, Li G, Liberzon I, Lu G, Luo Y, Magnotta V, Manthey A, Maron-Katz A, May G, McLaughlin K, Mueller S, Nawijn L, Nelson S, Neufeld R, Nitschke J, O'Leary E, Olatunji B, Olff M, Peverill M, Phan K, Qi R, Quidé Y, Rektor I, Ressler K, Riha P, Ross M, Rosso I, Salminen L, Sambrook K, Schmahl C, Shenton M, Sheridan M, Shih C, Sicorello M, Sierk A, Simmons A, Simons R, Simons J, Sponheim S, Stein M, Stein D, Stevens J, Straube T, Sun D, Théberge J, Thompson P, Thomopoulos S, van der Wee N, van der Werff S, van Erp T, van Rooij S, van Zuiden M, Varkevisser T, Veltman D, Vermeiren R, Walter H, Wang L, Wang X, Weis C, Winternitz S, Xie H, Zhu Y, Wall M, Neria Y, Morey R. Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium. NeuroImage 2023, 283: 120412. PMID: 37858907, PMCID: PMC10842116, DOI: 10.1016/j.neuroimage.2023.120412.
- Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAgeTamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.
- Biological embedding of early trauma: the role of higher prefrontal synaptic strengthTamman A, Jiang L, Averill C, Mason G, Averill L, Abdallah C. Biological embedding of early trauma: the role of higher prefrontal synaptic strength. European Journal Of Psychotraumatology 2023, 14: 2246338. PMID: 37642398, PMCID: PMC10467533, DOI: 10.1080/20008066.2023.2246338.
- DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress DisorderBenfer N, Grunthal B, Dondanville K, Young-McCaughan S, Blankenship A, Abdallah C, Back S, Flanagan J, Foa E, Fox P, Krystal J, Marx B, McGeary D, McLean C, Pruiksma K, Resick P, Roache J, Shiroma P, Sloan D, Taylor D, Wachen J, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Mintz J, Keane T, Peterson A, Litz B. DSM-5 Criterion-A-Based Trauma Types in Service Members and Veterans Seeking Treatment for Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2023 PMID: 37410416, PMCID: PMC10770283, DOI: 10.1037/tra0001537.
- Neural Integro-Differential EquationsZappala E, O. Fonseca A, Moberly A, Higley M, Abdallah C, Cardin J, Van Dijk D. Neural Integro-Differential Equations. Proceedings Of The AAAI Conference On Artificial Intelligence 2023, 37: 11104-11112. DOI: 10.1609/aaai.v37i9.26315.
- Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and VeteransStanley I, Marx B, Fina B, Young-McCaughan S, Tyler H, Sloan D, Blankenship A, Dondanville K, Walker J, Boffa J, Bryan C, Brown L, Straud C, Mintz J, Abdallah C, Back S, Blount T, DeBeer B, Flanagan J, Foa E, Fox P, Fredman S, Krystal J, McDevitt-Murphy M, McGeary D, Pruiksma K, Resick P, Roache J, Shiroma P, Taylor D, Wachen J, Kaplan A, López-Roca A, Nicholson K, Schobitz R, Schrader C, Sharrieff A, Yarvis J, Litz B, Keane T, Peterson A. Psychometric Properties of the Self-Injurious Thoughts and Behaviors Interview–Short Form Among U.S. Active Duty Military Service Members and Veterans. Assessment 2023, 30: 2332-2346. PMID: 36644835, DOI: 10.1177/10731911221143979.
- The potential of ketamine for posttraumatic stress disorder: a review of clinical evidenceRagnhildstveit A, Roscoe J, Bass L, Averill C, Abdallah C, Averill L. The potential of ketamine for posttraumatic stress disorder: a review of clinical evidence. Therapeutic Advances In Psychopharmacology 2023, 13: 20451253231154125. PMID: 36895431, PMCID: PMC9989422, DOI: 10.1177/20451253231154125.
- Brain Imaging in Psychiatry: Time to Move From Regions of Interest and Interpretive Analyses to Connectomes and Predictive Modeling?Abdallah C, Sheth S, Storch E, Goodman W. Brain Imaging in Psychiatry: Time to Move From Regions of Interest and Interpretive Analyses to Connectomes and Predictive Modeling? American Journal Of Psychiatry 2022, 180: 17-19. PMID: 36587267, DOI: 10.1176/appi.ajp.20220907.
- Reduced Prefrontal Synaptic Strength in Posttraumatic Stress Disorder (PTSD)Abdallah C. Reduced Prefrontal Synaptic Strength in Posttraumatic Stress Disorder (PTSD). Biological Psychiatry 2022, 91: s34. DOI: 10.1016/j.biopsych.2022.02.103.
- Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depressionSwanberg K, Prinsen H, Averill C, Campos L, Kurada A, Krystal J, Petrakis I, Averill L, Abdallah C, Juchem C. Abnormal glutamate metabolism in prefrontal cortex of post-traumatic stress disorder linked to comorbidity with major depression. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3344.
- Association Between Habenular Volume and Hemoglobin A1c in Young Adults Differs on the Basis of Smoking Status: Findings From the Human Connectome ProjectJha M, Kim J, Kenny P, Fatt C, Minhajuddin A, Salas R, Klein M, Ely B, Abdallah C, Xu J, Trivedi M. Association Between Habenular Volume and Hemoglobin A1c in Young Adults Differs on the Basis of Smoking Status: Findings From the Human Connectome Project. Biological Psychiatry 2021, 89: s271-s272. DOI: 10.1016/j.biopsych.2021.02.679.
- Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
- Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?Abdallah CG, Krystal JH. Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression? Behavioural Brain Research 2020, 390: 112628. PMID: 32407817, PMCID: PMC7316409, DOI: 10.1016/j.bbr.2020.112628.
- A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive DisorderNemati S, Akiki T, Ju Y, Averill C, Fouda S, Dutta A, Mckie S, Krystal J, Deakin B, Averill L, Abdallah C. A Shift in Executive Connectivity Predates and Predicts Response to Treatment in Major Depressive Disorder. Biological Psychiatry 2020, 87: s107. DOI: 10.1016/j.biopsych.2020.02.294.
- Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycinAbdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D’Souza D, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology 2020, 45: 990-997. PMID: 32092760, PMCID: PMC7162891, DOI: 10.1038/s41386-020-0644-9.
- Neurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress PathologiesAverill L, Averill C, Abdallah C. Neurobiological Mechanisms of Ketamine: Depression, Suicide, Trauma, and Chronic Stress Pathologies. Psychiatric Annals 2020, 50: 48-53. DOI: 10.3928/00485713-20200109-02.
- A Unique Brain Connectome Fingerprint Predates and Predicts Response to AntidepressantsNemati S, Akiki TJ, Roscoe J, Ju Y, Averill CL, Fouda S, Dutta A, McKie S, Krystal JH, Deakin JFW, Averill LA, Abdallah CG. A Unique Brain Connectome Fingerprint Predates and Predicts Response to Antidepressants. IScience 2019, 23: 100800. PMID: 31918047, PMCID: PMC6992944, DOI: 10.1016/j.isci.2019.100800.
- Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans StudyAverill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
- Neuroimaging Phenotypes Implicated For GWAS of PTSD Through The PGC And ENIGMA Worldwide ConsortiaMorey R, van Rooij S, Dennis E, Hayes J, Stevens J, Haswell C, Jahanshad N, Ipser J, Du Pleiss S, Abdallah C, Miller M, Ressler K, Seedat S, Thompson P, Logue M. Neuroimaging Phenotypes Implicated For GWAS of PTSD Through The PGC And ENIGMA Worldwide Consortia. European Neuropsychopharmacology 2019, 29: s750-s751. DOI: 10.1016/j.euroneuro.2017.06.093.
- The Neurobiology and Pharmacotherapy of Posttraumatic Stress DisorderAbdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. The Annual Review Of Pharmacology And Toxicology 2018, 59: 171-189. PMID: 30216745, PMCID: PMC6326888, DOI: 10.1146/annurev-pharmtox-010818-021701.
- The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics 2018, 190: 148-158. PMID: 29803629, PMCID: PMC6165688, DOI: 10.1016/j.pharmthera.2018.05.010.
- F152. Determining Human Brain Modular Architecture Using Subject-Level Functional Multilayer NetworksAkiki T, Abdallah C. F152. Determining Human Brain Modular Architecture Using Subject-Level Functional Multilayer Networks. Biological Psychiatry 2018, 83: s297. DOI: 10.1016/j.biopsych.2018.02.766.
- 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like SymptomsCortes-Briones J, Skosnik P, D’Souza D, Abdallah C, Petrakis I, Krystal J. 67 Ketamine-induced Changes in Neural Noise and their Relationship to Psychosis-like Symptoms. Biological Psychiatry 2017, 81: s28. DOI: 10.1016/j.biopsych.2017.02.078.
- 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal ApproachAkiki T, Averill C, Wrocklage K, Scott J, Alexander-Bloch A, Southwick S, Krystal J, Abdallah C. 581 The Default Mode Network in Posttraumatic Stress Disorder (PTSD): A Data-Driven Multimodal Approach. Biological Psychiatry 2017, 81: s235. DOI: 10.1016/j.biopsych.2017.02.451.
- 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC ConsortiaMorey R, Logue M, van Rooij S, Dennis E, Davis S, Hayes J, Stevens J, Densmore M, Koch S, Korgaonkar M, LeBois L, Peverill M, Jahanshad N, Lagopoulos J, Gueze E, Jovanovic T, Abdallah C, Bennett M, King A, Krystal J, Bryant R, Miller M, Veltman D, McLaughlin K, Lanius R, Stein D, Thomaes K, Liberzon I, Ressler K, Thompson P. 87 Volume of Sub-Cortical Structures in Posttraumatic Stress Disorder from Multi-Site Investigation by ENIGMA and PGC Consortia. Biological Psychiatry 2017, 81: s36-s37. DOI: 10.1016/j.biopsych.2017.02.099.
- Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical StudiesAverill L, Murrough J, Abdallah C. Ketamine’s Mechanism of Rapid Antidepressant Activity: Evidence Gleaned from Clinical Studies. 2016, 99-121. DOI: 10.1007/978-3-319-42925-0_7.
- Speaker 4: John Krystal, USAKrystal J, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal Of Neuropsychopharmacology 2016, 19: 19-19. PMCID: PMC5616528, DOI: 10.1093/ijnp/pyw042.052.
- KetamineAbdallah C, Krystal J. Ketamine. 2015, 857-862. DOI: 10.1007/978-3-642-36172-2_7031.
- KetamineAbdallah C, Krystal J. Ketamine. 2014, 1-6. DOI: 10.1007/978-3-642-27772-6_7031-1.