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Renato Polimanti, PhD, MSc

Associate Professor of Psychiatry

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Research Summary

My primary research focuses on investigating the predisposition to psychiatric disorders, behavioral traits, and other complex traits using genomic data. The ongoing studies are funded by the National Institute of Mental Health, the National Institute on Drug Abuse, the National Institute on Deafness and Other Communication Disorder, the Department of Veterans Affairs, Once Mind, and Alkermes.

Extensive Research Description

My research group is developing analytic approaches to investigate the polygenicity and pleiotropy of human traits and diseases using large-scale genome-wide datasets and multi-omics information. We apply a range of methods, such as polygenic risk scoring, causal inference analyses, and structural equation modeling, to dissect the molecular basis of complex traits and to understand how genetic information can be used to improve the healthcare of diverse populations.

Investigating the systems genetics of the patterns of polysubstance abuse and addiction. The aim of this project is to conduct a genome-wide analysis of polysubstance use patterns and investigate the results with respect to longitudinal data and epigenetic information.

Genome-wide Investigation of the Interplay Between Age-Related Hearing Loss and Smoking Behaviors. The aim of this project is to conduct a genome-wide analysis to understand the mechanisms by which smoking is associated with hearing loss.

Genomics of Gulf War illness (GWI) in veterans. The primary objective is to identify genetic variants associated with GWI, and also understand their interplay with Gulf War environmental exposures associated with the risk of developing GWI.

Integrating trait-specific design and multi-omics information to increase the portability of polygenic risk scoring across internalizing disorders. The aim of this project is to integrate and optimize of multiple features to improve the portability of PRS instruments across internalizing disorders affecting diverse populations.

The impact of socioeconomic factors on psychiatric and somatic comorbidities of schizophrenia: a genetically-informed epidemiological study. Our goal is to generate information that can be used to design initiatives more effective in reducing the impact of health disparities on SCZ morbidity and mortality.

Leveraging genomic data to dissect the association of internalizing disorders with the risk, onset, and vulnerability of COVID-19. This study will leverage genome-wide information together with other omics datasets to dissect the epidemiological and biological network linking internalizing disorders to COVID-19.

Coauthors

Research Interests

Biological Psychiatry; Genetics; Genetics, Behavioral; Genetics, Medical; Genetics, Population; Genetic Predisposition to Disease; Genetic Research; Genome-Wide Association Study; Mendelian Randomization Analysis; Gene-Environment Interaction

Public Health Interests

Genetics, Genomics, Epigenetics

Research Images

Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Mol Psychiatry. 2022 Aug 19. doi: 10.1038/s41380-022-01735-z.

EHR-based follow-up analysis. Relationship of PCL (PTSD checklist) total scores with the temporal difference between CAD (time of the diagnosis) and PCL (time of the assessment) in Million Veteran Program (MVP; left) and UK Biobank (UKB; right). In MVP, 17-item PCL (PCL-17) residuals were obtained regressing PCL-17 total score on age, sex, income, self-reported ethnicity, and self-reported racial background. In UKB, PCL-6 residuals were obtained regressing PCL-6 total score on age, sex, Townsend deprivation index, and self-reported ethnic background.

The Relationship of Attention-deficit/Hyperactivity Disorder with Post-traumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study. Biol. Psychiatry. Aug. 23, 2022. doi:10.1016/j.biopsych.2022.08.012

ADHD and PTSD Mendelian Randomization Results. (A) Casual effect of attention deficit hyperactivity disorder (ADHD) on posttraumatic stress disorder (PTSD) phenotypes (left), and PTSD phenotypes on ADHD (right). All estimates lack evidence of heterogeneity and horizontal pleiotropy among the genetic instruments. For clarity, inverse variance weighted (IVW) and MR robust adjusted profile score (MR-RAPS, which accounts for weak genetic instruments) estimates are shown graphically and estimates across MR methods are provided in eTable 4. Odds ratios and 95% confidence interval (CI) are reported for each MR test. The number of SNPs contributing to each genetic instrument is shown in parenthesis for each PTSD trait on the y-axis. Asterisks indicate significance after multiple testing correction accounting for all trait pairs and all MR causal inference methods applied (6 PTSD traits x 2 directions tested x 6 MR methods = 72 tests). (B) a directed acyclic diagram of multivariable MR results for ADHD and PTSD including bidirectional paths to covariates (green arrows) and direct causal paths to mediators (blue arrows) of the ADHD-PTSD relationship. All mediators and covariate traits were included in a single MVMR analysis. G indicates subsets of SNPs associated with one or more of the exposures. U indicates the effect of an unobserved confounder.

The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study. Int J Epidemiol . 2022 Jun 25;dyac129. doi: 10.1093/ije/dyac129.

Multivariable Mendelian randomization (MVMR). Arrows indicate the direction of the effect between the traits. ORs and P-values from each association are shown in the middle of the arrows for the univariate MR analysis (regular font) and the MVMR analysis (bold and underlined font). For the anthropometric traits, we report the estimates related to the MVMR model paired with household income (Income; Supplementary Tables S8 and S9, available as Supplementary data at IJE online). For Income, we report the estimate related to the MVMR model including all anthropometric traits with non-null effect in the univariable MR analysis (Supplementary Table S10, available as Supplementary data at IJE online). COVID-19 phenotypes are denoted by circles, whereas anthropometric and socio-economic traits are denoted by rectangles. Income, household income; BMI, body mass index; WC, waist circumference; HIP, hip circumference; OR, odds ratio; P, P-value.

An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. JAMA Psychiatry . 2022 Jul 1;79(7):667-676. doi: 10.1001/jamapsychiatry.2022.0914.

Mendelian Randomization (MR) Associations Linking Psychiatric and Immune-Related Traits After Adjustment for Other Risk Factors. MR associations between psychiatric and immune-related phenotypes that survived multiple test correction (false discovery rate Q score < .05). Node size is proportional to the genome-wide association study sample size. Images used were licensed or used with permission from multiple sources, including BioRender, Artist: Vectorwin, Alamy.com; Artist: Gan Khoon Lay, Iconfinder.com.

Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder. Mol Psychiatry . 2022 Apr;27(4):2206-2215. doi: 10.1038/s41380-022-01469-y.

Verifying the concordant genetic architectures of true and predicted internalizing outcomes. a, SNP-heritability (h2) of each internalizing outcome and the current largest unrelated sampling of a corresponding phenotype (GAD-2, PCL-17, and broad depression) after multi-trait conditioning with neuroticism. Each data point is the trait h2 point estimate and error bars represent the 95% confidence interval (CI) associated with each estimate. b, Genetic correlation (rg) within and between internalizing outcomes derived from the Mental Health Questionnaire (MHQ responders) and those predicted in the MHQ non-responders of the UKB before (bottom left triangle) and after (top right triangle) multi-trait conditioning with neuroticism. Pale text indicates a phenotype from the MHQ non-responders and dark text indicates a phenotype from the MHQ responders. Each rg heatmap contains a positive control with positive rg (largest Million Veteran Program (MVP) corresponding phenotype) and positive control with negative rg (subjective well-being) phenotype. All rgs survive multiple testing correction (FDR<0.05).

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Mol Psychiatry . 2022 Mar;27(3):1394-1404. doi: 10.1038/s41380-022-01488-9.

Three-tiered Manhattan plots of PTSD symptoms: Avoidance, Hyperarousal, and Reexperiencing. The lowest layer is TWAS, middle is SPWAS, and top is PWAS (See text for more details). The Venn diagram of overlapping genes across the three PTSD symptom clusters.

Pleiotropic effects of telomere length loci with brain morphology, and brain tissue expression. Hum Mol Genet. 2021 Jun 26;30(14):1360-1370. doi: 10.1093/hmg/ddab102.

Schematic presenting the hypothesis and four major domains studied – i) shared genomic regions between leukocyte telomere length (LTL) and brain volume measures, and gene-based associations for LTL in brain tissue-based ii) transcriptomics – combined brain tissue (meta-analyzed from different regions of the brains) and prefrontal cortex, iii) methylomics – combined brain tissues (meta-analyzed), and iv) Hi-C chromatin profiles – adult and fetal brain, astrocytes and neurons.

Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality. Neurobiol Stress. 2021 Feb 18;14:100309. doi: 10.1016/j.ynstr.2021.100309.

Individual relevance of the environment included in the covariance matrix used to detect gene-by-environment (GxE) interactions with suicidality. Each bar represents the log marginal likelihood (log (Bayes factor (BF))) of models for the indicated environment relative to models lacking that environment.

Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support. Neuropsychopharmacology. 2020 Mar 16. doi: 10.1038/s41386-020-0655-6.

Genetic correlation (x-axis: genetic correlation, rg; y-axis: -log10P-value) of serum C-reactive protein (CRP) with posttraumatic stress, trauma response, trauma exposure, social support, and socioeconomic status. Full circles represent nominally significant genetic correlations (p<0.05). As expected, CRP showed a positive genetic correlation with posttraumatic stress, trauma response, trauma exposure, and deprivation index and negative genetic correlation with social support and household income.

Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder: A Mendelian Randomization Study. JAMA Netw Open. 2019 May 3;2(5):e193447. doi: 10.1001/jamanetworkopen.2019.3447.

Enrichment Analyses for Educational Attainment and Income. A, Tissue-specific enrichments (brain tissues are indicated with solid circles; nonbrain tissues are indicated with open circles). B, Cell-type enrichments that were at least nominally significant (P < .05) in both traits. BA9 indicates Brodmann area 9; BA24,Brodmann area 24; exCA1, excitatory neurons in hippocampal subfield CA1; exDG, excitatory neurons in dentate gyrus; exPFC1, excitatory neurons in prefrontal cortex 1; GABA, γ-aminobutyric acid; and PFC, prefrontal cortex.

Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits

PRS results (Z scores) for psychiatric/behavioral traits × local-adaptation variables. Positive and negative associations are indicated in blue and red, respectively (bright shade q < 0.05, light shade p < 0.05). White cells indicate associations with p > 0.05. Genome Med. 2018 Mar 26;10(1):24. doi: 10.1186/s13073-018-0532-7.

Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder. PLoS Genet. 2017 Feb 10;13(2):e1006618. doi: 10.1371/journal.pgen.1006618.

Similarity network based on GO enrichment results. Bubble color indicates the GO p-value; bubble size indicates the frequency of the GO term in the Gene Ontology Annotation (UniProt-GOA) Database which annotates all UniProt entries with GO terms. Highly similar GO terms are linked by edges in the graph, where the line width indicates the degree of similarity.

A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder. Genome Med. 2017 Nov 27;9(1):99. doi: 10.1186/s13073-017-0491-4.

SNP-exposure (WCadj associations) and SNP-outcome (PTSD associations) coefficients used in the MR analysis. Error bars (95% CIs) are reported for each association. The solid line represents the inverse-variance-weighted estimate.

Selected Publications

Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disordersKoller D, Benítez-Burraco A, Polimanti R. Enrichment of self-domestication and neural crest function loci in the heritability of neurodevelopmental disorders Human Genetics 2023, 1-9. PMID: 36930228, DOI: 10.1007/s00439-023-02541-5.
Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating DisordersKoller D, Pathak G, Wendt F, Tylee D, Levey D, Overstreet C, Gelernter J, Taylor H, Polimanti R. Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders JAMA Network Open 2023, 6: e2251214. PMID: 36652249, PMCID: PMC9856929, DOI: 10.1001/jamanetworkopen.2022.51214.
Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomesWendt F, Pathak G, Polimanti R. Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes Nature Communications 2022, 13: 7682. PMID: 36509785, PMCID: PMC9744822, DOI: 10.1038/s41467-022-35423-x.
Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populationsKoller D, Wendt F, Pathak G, De Lillo A, De Angelis F, Cabrera-Mendoza B, Tucci S, Polimanti R. Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations BMC Biology 2022, 20: 249. PMID: 36344982, PMCID: PMC9641937, DOI: 10.1186/s12915-022-01449-2.
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health recordsPolimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, DOI: 10.1038/s41380-022-01735-z.
An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related PhenotypesTylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes JAMA Psychiatry 2022, 79: 667-676. PMID: 35507366, PMCID: PMC9069342, DOI: 10.1001/jamapsychiatry.2022.0914.
The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization studyCabrera-Mendoza B, Wendt FR, Pathak GA, De Angelis F, De Lillo A, Koller D, Polimanti R. The association of obesity-related traits on COVID-19 severity and hospitalization is affected by socio-economic status: a multivariable Mendelian randomization study International Journal Of Epidemiology 2022, 51: 1371-1383. PMID: 35751636, PMCID: PMC9278255, DOI: 10.1093/ije/dyac129.
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic eventsWendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.
Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorderWendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.
The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expressionPathak GA, De Lillo A, Wendt FR, De Angelis F, Koller D, Mendoza B, Jacoby D, Miller EJ, Buxbaum JN, Polimanti R. The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression Amyloid 2021, 29: 110-119. PMID: 34935565, PMCID: PMC9213571, DOI: 10.1080/13506129.2021.2018678.
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic riskDe Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk Translational Psychiatry 2021, 11: 586. PMID: 34775470, PMCID: PMC8590689, DOI: 10.1038/s41398-021-01713-z.
Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin UseWendt FR, Koller D, Pathak GA, Jacoby D, Miller EJ, Polimanti R. Biobank Scale Pharmacogenomics Informs the Genetic Underpinnings of Simvastatin Use Clinical Pharmacology & Therapeutics 2021, 110: 777-785. PMID: 33837531, PMCID: PMC8376807, DOI: 10.1002/cpt.2260.
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.De Lillo A, D'Antona S, Pathak GA, Wendt FR, De Angelis F, Fuciarelli M, Polimanti R. Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank. Human Molecular Genetics 2021, 30: 1457-1467. PMID: 33890984, PMCID: PMC8283210, DOI: 10.1093/hmg/ddab114.
Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30: 1360-1370. PMID: 33831179, PMCID: PMC8255129, DOI: 10.1093/hmg/ddab102.
Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidalityPolimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality Translational Psychiatry 2021, 11: 34. PMID: 33431810, PMCID: PMC7801457, DOI: 10.1038/s41398-020-01153-1.
Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid MechanismsPathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms Circulation Genomic And Precision Medicine 2021, 14: e003011. PMID: 33428857, PMCID: PMC7887108, DOI: 10.1161/circgen.120.003011.
Multivariate genome-wide analysis of education, socioeconomic status and brain phenomeWendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome Nature Human Behaviour 2020, 5: 482-496. PMID: 33349686, PMCID: PMC8068566, DOI: 10.1038/s41562-020-00980-y.
Characterizing the effect of background selection on the polygenicity of brain-related traitsWendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Characterizing the effect of background selection on the polygenicity of brain-related traits Genomics 2020, 113: 111-119. PMID: 33278486, PMCID: PMC7855394, DOI: 10.1016/j.ygeno.2020.11.032.
Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social supportMuniz Carvalho C, Wendt FR, Maihofer AX, Stein DJ, Stein MB, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support Neuropsychopharmacology 2020, 46: 1071-1077. PMID: 32179874, PMCID: PMC8115274, DOI: 10.1038/s41386-020-0655-6.
Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization StudyCarvalho CM, Wendt FR, Stein DJ, Stein MB, Gelernter J, Belangero SI, Polimanti R. Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study Molecular Neurobiology 2019, 57: 1542-1552. PMID: 31786776, DOI: 10.1007/s12035-019-01823-2.
Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric DisordersWendt FR, Carvalho C, Pathak GA, Gelernter J, Polimanti R. Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders Journal Of Clinical Medicine 2019, 8: 2040. PMID: 31766499, PMCID: PMC6947231, DOI: 10.3390/jcm8122040.
Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidosesDe Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Frusconi S, Manfellotto D, Fuciarelli M, Polimanti R. Phenome-wide association study of TTR and RBP4 genes in 361,194 individuals reveals novel insights in the genetics of hereditary and wildtype transthyretin amyloidoses Human Genetics 2019, 138: 1331-1340. PMID: 31659433, DOI: 10.1007/s00439-019-02078-6.
Association of Economic Status and Educational Attainment With Posttraumatic Stress DisorderPolimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder JAMA Network Open 2019, 2: e193447. PMID: 31050786, PMCID: PMC6503495, DOI: 10.1001/jamanetworkopen.2019.3447.
Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortiumPolimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg H, Kendler K, Lewis C, Sullivan P, Wray N, Gelernter J, Derks E. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium Psychological Medicine 2019, 49: 1218-1226. PMID: 30929657, PMCID: PMC6565601, DOI: 10.1017/s0033291719000667.
Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding VariantsPolimanti R, Nuñez YZ, Gelernter J. Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants Journal Of Clinical Medicine 2019, 8: 269. PMID: 30813263, PMCID: PMC6406512, DOI: 10.3390/jcm8020269.
Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid DisordersRavera S, Carrasco N, Gelernter J, Polimanti R. Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders Journal Of Clinical Medicine 2018, 7: 296. PMID: 30248900, PMCID: PMC6210201, DOI: 10.3390/jcm7100296.
Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traitsPolimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits Genome Medicine 2018, 10: 24. PMID: 29580271, PMCID: PMC5870256, DOI: 10.1186/s13073-018-0532-7.
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorderPolimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J, for The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup. A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder Genome Medicine 2017, 9: 99. PMID: 29178946, PMCID: PMC5702961, DOI: 10.1186/s13073-017-0491-4.
Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosisIorio A, De Lillo A, De Angelis F, Di Girolamo M, Luigetti M, Sabatelli M, Pradotto L, Mauro A, Mazzeo A, Stancanelli C, Perfetto F, Frusconi S, My F, Manfellotto D, Fuciarelli M, Polimanti R. Non-coding variants contribute to the clinical heterogeneity of TTR amyloidosis European Journal Of Human Genetics 2017, 25: 1055-1060. PMID: 28635949, PMCID: PMC5558178, DOI: 10.1038/ejhg.2017.95.
ADH1B: From alcoholism, natural selection, and cancer to the human phenomePolimanti R, Gelernter J. ADH1B: From alcoholism, natural selection, and cancer to the human phenome American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 177: 113-125. PMID: 28349588, PMCID: PMC5617762, DOI: 10.1002/ajmg.b.32523.
Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosisIorio A, De Angelis F, Di Girolamo M, Luigetti M, Pradotto LG, Mazzeo A, Frusconi S, My F, Manfellotto D, Fuciarelli M, Polimanti R. Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis BMC Genomics 2017, 18: 254. PMID: 28335735, PMCID: PMC5364715, DOI: 10.1186/s12864-017-3646-1.
Schizophrenia and substance use comorbidity: a genome-wide perspectivePolimanti R, Agrawal A, Gelernter J. Schizophrenia and substance use comorbidity: a genome-wide perspective Genome Medicine 2017, 9: 25. PMID: 28327175, PMCID: PMC5359801, DOI: 10.1186/s13073-017-0423-3.
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locusPolimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus Molecular Psychiatry 2017, 23: 154-160. PMID: 28265120, PMCID: PMC5589475, DOI: 10.1038/mp.2017.24.
Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorderPolimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder PLOS Genetics 2017, 13: e1006618. PMID: 28187187, PMCID: PMC5328401, DOI: 10.1371/journal.pgen.1006618.
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk GenePolimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene Neuropsychopharmacology 2016, 42: 598-605. PMID: 27531626, PMCID: PMC5240175, DOI: 10.1038/npp.2016.153.
Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 WomenPolimanti R, Kranzler HR, Gelernter J. Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women Neuropsychopharmacology 2016, 41: 2688-2696. PMID: 27187070, PMCID: PMC5026736, DOI: 10.1038/npp.2016.72.

Clinical Trials

Conditions	Study Title
Mental Health & Behavioral Research; COVID-19 Inpatient; COVID-19 Outpatient	Have you had COVID-19?

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