Joel Gelernter, MD

• Adam Chekroud
• Adam Mecca
• Allen Bale
• Amy Justice
• Arie Kaffman
• Bao-Zhu Yang
• Brenda Cabrera-Mendoza
• Brenda Cartmel
• Carolyn Fredericks
• Chiang-Shan Ray Li
• Christopher T Rentsch
• Christopher van Dyck
• Dan Oren
• Daniel F. Levey
• Daniel Tylee
• David J Leffell
• Dora Koller
• Elise DeVito
• Elizabeth Goldfarb
• Fei Wang
• Gita Pathak
• Godfrey Pearlson
• Guido Falcone
• Hang Zhou
• Heping Zhang
• Hilary Blumberg
• Hongyu Zhao
• Ilan Harpaz-Rotem
• In-Hyun Park
• Irina Esterlis
• Ismene Petrakis
• James Duncan
• Janitza Montalvo-Ortiz
• Jeffrey R Gruen
• Jiawei Wang
• John Concato
• John Krystal
• Joseph D. Deak
• Julie Gaither
• Keith Hawkins
• Kenneth Kidd
• Keyrun Adhikari
• Kirsha Gordon, PhD, MS
• Lara Chepenik
• Laura Huckins
• Lawrence Staib
• Leah Ferrucci
• Lingeng Lu
• Marina Picciotto
• Matthew Girgenti
• Meghan Rabbitt Morean
• Michael Stevens
• Mihaela Aslan
• Nabeel Nabulsi
• Nallakkandi Rajeevan
• Ning Sun
• Paul Desan
• Perry Miller
• Peter Jongho Na
• Prakash Nadkarni
• Renato Polimanti
• Richard Bronen
• Robert King
• Robert Pietrzak
• Robert Rosenheck
• Ruth Asch
• Sheila Nagamatsu
• Thomas Fernandez
• Xingguang Luo

Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders

• Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk lociDeak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci Molecular Psychiatry 2022, 27: 3970-3979. PMID: 35879402, PMCID: PMC9718667, DOI: 10.1038/s41380-022-01709-1.
• Genetics of substance use disorders in the era of big dataGelernter J, Polimanti R. Genetics of substance use disorders in the era of big data Nature Reviews Genetics 2021, 22: 712-729. PMID: 34211176, PMCID: PMC9210391, DOI: 10.1038/s41576-021-00377-1.
• Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directionsLevey DF, Stein MB, Wendt FR, Pathak GA, Zhou H, Aslan M, Quaden R, Harrington KM, Nuñez YZ, Overstreet C, Radhakrishnan K, Sanacora G, McIntosh AM, Shi J, Shringarpure SS, Concato J, Polimanti R, Gelernter J. Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions Nature Neuroscience 2021, 24: 954-963. PMID: 34045744, PMCID: PMC8404304, DOI: 10.1038/s41593-021-00860-2.
• Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran ProgramStein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program Nature Genetics 2021, 53: 174-184. PMID: 33510476, PMCID: PMC7972521, DOI: 10.1038/s41588-020-00767-x.
• Association of OPRM1 Functional Coding Variant With Opioid Use DisorderZhou H, Rentsch CT, Cheng Z, Kember RL, Nunez YZ, Sherva RM, Tate JP, Dao C, Xu K, Polimanti R, Farrer LA, Justice AC, Kranzler HR, Gelernter J. Association of OPRM1 Functional Coding Variant With Opioid Use Disorder JAMA Psychiatry 2020, 77: 1072-1080. PMID: 32492095, PMCID: PMC7270886, DOI: 10.1001/jamapsychiatry.2020.1206.
• Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traitsZhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits Nature Neuroscience 2020, 23: 809-818. PMID: 32451486, PMCID: PMC7485556, DOI: 10.1038/s41593-020-0643-5.
• Exploring the genetic overlap between twelve psychiatric disordersRomero C, Werme J, Jansen P, Gelernter J, Stein M, Levey D, Polimanti R, de Leeuw C, Posthuma D, Nagel M, van der Sluis S. Exploring the genetic overlap between twelve psychiatric disorders Nature Genetics 2022, 54: 1795-1802. PMID: 36471075, DOI: 10.1038/s41588-022-01245-2.
• Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohortNagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.
• Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden.Nichter B, Koller D, De Angelis F, Wang J, Girgenti M, Na P, Hill M, Norman S, Krystal J, Gelernter J, Polimanti R, Pietrzak R. Genetic liability to suicidal thoughts and behaviors and risk of suicide attempt in US military veterans: moderating effects of cumulative trauma burden. Psychological Medicine 2022, 1-9. PMID: 36444557, DOI: 10.1017/s0033291722003646.
• Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participantsOverstreet C, Levey D, Zhou H, Harrington K, Quaden R, Stein M, Gelernter J, Pietrzak R, Program M. Factor structure of the posttraumatic stress disorder checklist (PCL-17) in 279,897 million veteran program participants Psychiatry Research 2022, 319: 114994. PMID: 36516638, DOI: 10.1016/j.psychres.2022.114994.
• A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or MortalityVerma A, Minnier J, Wan ES, Huffman JE, Gao L, Joseph J, Ho YL, Wu WC, Cho K, Gorman BR, Rajeevan N, Pyarajan S, Garcon H, Meigs JB, Sun YV, Reaven PD, McGeary JE, Suzuki A, Gelernter J, Lynch JA, Petersen JM, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Gatsby E, Lynch KE, Bonomo RA, Freiberg M, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Huang R, Polimanti R, Chang KM, Liao KP, Tsao PS, Wilson PWF, Hung A, O’Donnell C, Gaziano JM, Hauger RL, Iyengar S, Luoh SW, Initiative T. A MUC5B Gene Polymorphism, rs35705950-T, Confers Protective Effects Against COVID-19 Hospitalization but Not Severe Disease or Mortality American Journal Of Respiratory And Critical Care Medicine 2022, 206: 1220-1229. PMID: 35771531, PMCID: PMC9746845, DOI: 10.1164/rccm.202109-2166oc.
• Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathologyLam M, Chen C, Hill W, Xia C, Tian R, Levey D, Gelernter J, Stein M, Hatoum A, Huang H, Malhotra A, Runz H, Ge T, Lencz T. Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology Nature Communications 2022, 13: 6868. PMID: 36369282, PMCID: PMC9652380, DOI: 10.1038/s41467-022-34418-y.
• Factor Structure of the Posttraumatic Stress Disorder Checklist (PCL-17) in 279,897 Million Veteran Program ParticipantsOverstreet C, Levey D, Zhou H, Harrington K, Quaden R, Stein M, Gelernter J, Pietrzak R, Program M. Factor Structure of the Posttraumatic Stress Disorder Checklist (PCL-17) in 279,897 Million Veteran Program Participants Psychiatry Research 2022, 114994. DOI: 10.1016/j.psychres.2022.114994.
• Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cellsLynall ME, Soskic B, Hayhurst J, Schwartzentruber J, Levey DF, Pathak GA, Polimanti R, Gelernter J, Stein MB, Trynka G, Clatworthy MR, Bullmore E. Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells Nature Communications 2022, 13: 6102. PMID: 36243721, PMCID: PMC9569335, DOI: 10.1038/s41467-022-33885-7.
• Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond.Gaddis N, Mathur R, Marks J, Zhou L, Quach B, Waldrop A, Levran O, Agrawal A, Randesi M, Adelson M, Jeffries PW, Martin NG, Degenhardt L, Montgomery GW, Wetherill L, Lai D, Bucholz K, Foroud T, Porjesz B, Runarsdottir V, Tyrfingsson T, Einarsson G, Gudbjartsson DF, Webb BT, Crist RC, Kranzler HR, Sherva R, Zhou H, Hulse G, Wildenauer D, Kelty E, Attia J, Holliday EG, McEvoy M, Scott RJ, Schwab SG, Maher BS, Gruza R, Kreek MJ, Nelson EC, Thorgeirsson T, Stefansson K, Berrettini WH, Gelernter J, Edenberg HJ, Bierut L, Hancock DB, Johnson EO. Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. Scientific Reports 2022, 12: 16873. PMID: 36207451, PMCID: PMC9546890, DOI: 10.1038/s41598-022-21003-y.
• Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use DisorderDeak JD, Levey DF, Wendt FR, Zhou H, Galimberti M, Kranzler HR, Gaziano JM, Stein MB, Polimanti R, Gelernter J, Muralidhar S, Moser J, Deen J, Gaziano J, Beckham J, Chang K, Tsao P, Luoh S, Casas J, Churby L, Whitbourne S, Brewer J, Brophy M, Selva L, Shayan S, Cho K, Pyarajan S, DuVall S, Connor T, Argyres D, Aslan M, Stephens B, Concato J, Gelernter J, Gleason T, Huang G, Koenen K, Marx C, Radhakrishnan K, Schork N, Stein M, Zhao H, Kaufman J, Nunez Y, Pietrzak R, Beck D, Cissell S, Crutchfield P, Lance W, Cheung K, Li Y, Sun N, Chen Q, Rajeevan N, Sayward F, Gagnon D, Harrington K, Quaden R, O'Leary T, Ramoni R. Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder JAMA Network Open 2022, 5: e2238880. PMID: 36301540, PMCID: PMC9614582, DOI: 10.1001/jamanetworkopen.2022.38880.
• 10. LARGE-SCALE MULTI-ANCESTRY GENOME-WIDE ASSOCIATION META-ANALYSIS OF MAJOR DEPRESSIONMeng X, Giannakopoulou O, Navoly G, Koller D, Levey D, Koen N, Loos R, Davis L, Martin N, MDD T, Walters R, Polimanti R, Stein M, Gelernter J, Kuchenbaecker K. 10. LARGE-SCALE MULTI-ANCESTRY GENOME-WIDE ASSOCIATION META-ANALYSIS OF MAJOR DEPRESSION European Neuropsychopharmacology 2022, 63: e49. DOI: 10.1016/j.euroneuro.2022.07.101.
• POLYGENIC RISK SCORE FOR THE PREDICTION OF ALCOHOL USE DISORDER COMORBIDITIES IN THE NATIONAL HEALTH AND RESILIENCE IN VETERANS STUDY COHORTMendoza B, De Lillo A, Gelernter J, Pietrzak R, Polimanti R. POLYGENIC RISK SCORE FOR THE PREDICTION OF ALCOHOL USE DISORDER COMORBIDITIES IN THE NATIONAL HEALTH AND RESILIENCE IN VETERANS STUDY COHORT European Neuropsychopharmacology 2022, 63: e161-e162. DOI: 10.1016/j.euroneuro.2022.07.295.
• Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addictionKember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell EE, Crist RC, Rentsch CT, Davis L, Justice A, Sanchez-Roige S, Kampman K, Gelernter J, Kranzler H. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction Nature Neuroscience 2022, 25: 1279-1287. PMID: 36171425, PMCID: PMC9682545, DOI: 10.1038/s41593-022-01160-z.
• Psychosocial factors associated with accelerated GrimAge in male U.S. military veteransTamman AJF, Nagamatsu S, Krystal JH, Gelernter J, Montalvo-Ortiz JL, Pietrzak RH. Psychosocial factors associated with accelerated GrimAge in male U.S. military veterans American Journal Of Geriatric Psychiatry 2022 PMID: 36210262, DOI: 10.1016/j.jagp.2022.09.002.
• The Relationship of Attention-deficit/Hyperactivity Disorder with Post-traumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study.Wendt FR, Garcia-Argibay M, Cabrera-Mendoza B, Valdimarsdóttir UA, Gelernter J, Stein MB, Nivard MG, Maihofer AX, Nievergelt C, Larsson H, Mattheisen M, Polimanti R, Meier S, Maihofer A, Choi K, Coleman J, Daskalakis N, Denckla C, Ketema E, Morey R, Polimanti R, Ratanatharathorn A, Torres K, Wingo A, Zai C, Aiello A, Almli L, Amstadter A, Andersen S, Andreassen O, Arbisi P, Ashley-Koch A, Austin S, Avdibegovic E, Borglum A, Babic D, Bækvad-Hansen M, Baker D, Beckham J, Bierut L, Bisson J, Boks M, Bolger E, Bradley B, Brashear M, Breen G, Bryant R, Bustamante A, Bybjerg-Grauholm J, Calabrese J, Caldas-de-Almeida J, Chen C, Dale A, Dalvie S, Deckert J, Delahanty D, Dennis M, Disner S, Domschke K, Duncan L, Kulenovic A, Erbes C, Evans A, Farrer L, Feeny N, Flory J, Forbes D, Franz C, Galea S, Garrett M, Gautam A, Gelaye B, Gelernter J, Geuze E, Gillespie C, Uka A, Gordon S, Guffanti G, Hammamieh R, Hauser M, Heath A, Hemmings S, Hougaard D, Jakovljevic M, Jett M, Johnson E, Jones I, Jovanovic T, Qin X, Karstoft K, Kaufman M, Kessler R, Khan A, Kimbrel N, King A, Koen N, Kranzler H, Kremen W, Lawford B, Lebois L, Lewis C, Liberzon I, Linnstaedt S, Logue M, Lori A, Lugonja B, Luykx J, Lyons M, Maples-Keller J, Marmar C, Martin N, Maurer D, Mavissakalian M, McFarlane A, McGlinchey R, McLaughlin K, McLean S, Mehta D, Mellor R, Michopoulos V, Milberg W, Miller M, Morris C, Mors O, Mortensen P, Nelson E, Nordentoft M, Norman S, O’Donnell M, Orcutt H, Panizzon M, Peters E, Peterson A, Peverill M, Pietrzak R, Polusny M, Rice J, Risbrough V, Roberts A, Rothbaum A, Rothbaum B, Roy-Byrne P, Ruggiero K, Rung A, Rutten B, Saccone N, Sanchez S, Schijven D, Seedat S, Seligowski A, Seng J, Sheerin C, Silove D, Smith A, Smoller J, Sponheim S, Stein D, Stevens J, Teicher M, Thompson W, Trapido E, Uddin M, Ursano R, Luella van den Heuvel L, Van Hooff M, Vermetten E, Vinkers C, Voisey J, Wang Y, Wang Z, Werge T, Williams M, Williamson D, Winternitz S, Wolf C, Wolf E, Yehuda R, Young K, Young R, Zhao H, Zoellner L, Haas M, Lasseter H, Provost A, Salem R, Sebat J, Shaffer R, Wu T, Ripke S, Daly M, Ressler K, Koenen K, Stein M, Nievergelt C. The Relationship of Attention-deficit/Hyperactivity Disorder with Post-traumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study. Biological Psychiatry 2022 PMID: 36335070, DOI: 10.1016/j.biopsych.2022.08.012.
• Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health recordsPolimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, DOI: 10.1038/s41380-022-01735-z.
• Phenome-wide association analysis of substance use disorders in a deeply-phenotyped sampleKember RL, Hartwell EE, Xu H, Rotenberg J, Almasy L, Zhou H, Gelernter J, Kranzler HR. Phenome-wide association analysis of substance use disorders in a deeply-phenotyped sample Biological Psychiatry 2022 PMID: 36273948, DOI: 10.1016/j.biopsych.2022.08.010.
• Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traitsToikumo S, Xu H, Gelernter J, Kember RL, Kranzler HR. Integrating human brain proteomic data with genome-wide association study findings identifies novel brain proteins in substance use traits Neuropsychopharmacology 2022, 47: 2292-2299. PMID: 35941285, PMCID: PMC9630289, DOI: 10.1038/s41386-022-01406-1.
• Sex-Specific Genetic and Transcriptomic Liability to NeuroticismWendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Sex-Specific Genetic and Transcriptomic Liability to Neuroticism Biological Psychiatry 2022, 93: 243-252. PMID: 36244801, DOI: 10.1016/j.biopsych.2022.07.019.
• Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell TraitVerma A, Huffman JE, Gao L, Minnier J, Wu WC, Cho K, Ho YL, Gorman BR, Pyarajan S, Rajeevan N, Garcon H, Joseph J, McGeary JE, Suzuki A, Reaven PD, Wan ES, Lynch JA, Petersen JM, Meigs JB, Freiberg MS, Gatsby E, Lynch KE, Zekavat SM, Natarajan P, Dalal S, Jhala DN, Arjomandi M, Bonomo RA, Thompson TK, Pathak GA, Zhou JJ, Donskey CJ, Madduri RK, Wells QS, Gelernter J, Huang RDL, Polimanti R, Chang KM, Liao KP, Tsao PS, Sun YV, Wilson PWF, O’Donnell C, Hung AM, Gaziano JM, Hauger RL, Iyengar SK, Luoh SW, Muralidhar S, Beckham J, Moser J, Thomann L, Garcon H, Kosik N, Damrauer S, Assimes T, Roussos P, Striker R, Tuteja S, DuVall S, Lynch K, Gatsby E, Ramoni R, Breeling J, Huang G, Whitbourne S, Brewer J, Aslan M, Connor T, Argyres D, Stephens B, Brophy M, Humphries D, Selva L, Do N, Shayan S, Churby L, Hauser E, Zhao H, Wilson P, McArdle R, Dellitalia L, Mattocks K, Harley J, Whittle J, Jacono F, Wells J, Gutierrez S, Gibson G, Hammer K, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Mathew R, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Ivins D, Mastorides S, Moorman J, Gappy S, Klein J, Ratcliffe N, Florez H, Okusaga O, Murdoch M, Sriram P, Yeh S, Tandon N, Jhala D, Aguayo S, Cohen D, Sharma S, Liangpunsakul S, Oursler K, Whooley M, Ahuja S, Constans J, Meyer P, Greco J, Rauchman M, Servatius R, Gaddy M, Wallbom A, Morgan T, Stapley T, Sherman S, Ross G, Tsao P, Strollo P, Boyko E, Meyer L, Gupta S, Huq M, Fayad J, Hung A, Lichy J, Hurley R, Robey B. Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait JAMA Internal Medicine 2022, 182: 796-804. PMID: 35759254, PMCID: PMC9237798, DOI: 10.1001/jamainternmed.2022.2141.
• Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effectsTopiwala A, Taschler B, Ebmeier KP, Smith S, Zhou H, Levey DF, Codd V, Samani NJ, Gelernter J, Nichols TE, Burgess S. Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol’s effects Molecular Psychiatry 2022, 27: 4001-4008. PMID: 35879401, PMCID: PMC9718662, DOI: 10.1038/s41380-022-01690-9.
• Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analysesTopiwala A, Wang C, Ebmeier KP, Burgess S, Bell S, Levey DF, Zhou H, McCracken C, Roca-Fernández A, Petersen SE, Raman B, Husain M, Gelernter J, Miller KL, Smith SM, Nichols TE. Associations between moderate alcohol consumption, brain iron, and cognition in UK Biobank participants: Observational and mendelian randomization analyses PLOS Medicine 2022, 19: e1004039. PMID: 35834561, PMCID: PMC9282660, DOI: 10.1371/journal.pmed.1004039.
• Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathwaysWatanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds D, Gelernter J, Levey D, Polimanti R, Stein M, Van Someren E, Smit A, Posthuma D. Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways Nature Genetics 2022, 54: 1125-1132. PMID: 35835914, DOI: 10.1038/s41588-022-01124-w.
• Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive DisorderOslin DW, Lynch KG, Shih MC, Ingram EP, Wray LO, Chapman SR, Kranzler HR, Gelernter J, Pyne JM, Stone A, DuVall SL, Lehmann LS, Thase ME, Aslam M, Batki S, Bjork J, Blow F, Brenner L, Chen P, Desai S, Dieperink E, Fears S, Fuller M, Goodman C, Graham D, Haas G, Hamner M, Helstrom A, Hurley R, Icardi M, Jurjus G, Kilbourne A, Kreyenbuhl J, Lache D, Lieske S, Lynch J, Meyer L, Montalvo C, Muralidhar S, Ostacher M, Paschall G, Pfeiffer P, Prieto S, Przygodzki R, Ranganathan M, Rodriguez-Suarez M, Roggenkamp H, Schichman S, Schneeweis J, Simonetti J, Steinhauer S, Suppes T, Umbert M, Vassy J, Voora D, Wiechers I, Wood A. Effect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder JAMA 2022, 328: 151-161. PMID: 35819423, PMCID: PMC9277497, DOI: 10.1001/jama.2022.9805.
• Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans.Na PJ, Montalvo-Ortiz JL, Nagamatsu ST, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Association of Symptoms of Posttraumatic Stress Disorder and GrimAge, an Epigenetic Marker of Mortality Risk, in US Military Veterans. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35802930, DOI: 10.4088/jcp.21br14309.
• An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related PhenotypesTylee DS, Lee YK, Wendt FR, Pathak GA, Levey DF, De Angelis F, Gelernter J, Polimanti R. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes JAMA Psychiatry 2022, 79: 667-676. PMID: 35507366, PMCID: PMC9069342, DOI: 10.1001/jamapsychiatry.2022.0914.
• Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system functionLove T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR. Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function Neuropsychopharmacology 2022, 47: 1784-1790. PMID: 35545664, PMCID: PMC9372136, DOI: 10.1038/s41386-022-01325-1.
• Characterizing the Genetic Effects Linking Psychiatric and Immune-Related PhenotypesTylee D, Lee Y, Wendt F, Pathak G, Levey D, De Angelis F, Gelernter J, Polimanti R. Characterizing the Genetic Effects Linking Psychiatric and Immune-Related Phenotypes Biological Psychiatry 2022, 91: s72-s73. DOI: 10.1016/j.biopsych.2022.02.200.
• Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorderWingo TS, Gerasimov ES, Liu Y, Duong DM, Vattathil SM, Lori A, Gockley J, Breen MS, Maihofer AX, Nievergelt CM, Koenen KC, Levey DF, Gelernter J, Stein MB, Ressler KJ, Bennett DA, Levey AI, Seyfried NT, Wingo AP. Integrating human brain proteomes with genome-wide association data implicates novel proteins in post-traumatic stress disorder Molecular Psychiatry 2022, 27: 3075-3084. PMID: 35449297, PMCID: PMC9233006, DOI: 10.1038/s41380-022-01544-4.
• Alcohol withdrawal in past‐year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic surveyLivne O, Feinn R, Knox J, Hartwell EE, Gelernter J, Hasin DS, Kranzler HR. Alcohol withdrawal in past‐year drinkers with unhealthy alcohol use: Prevalence, characteristics, and correlates in a national epidemiologic survey Alcoholism Clinical And Experimental Research 2022, 46: 422-433. PMID: 35275407, PMCID: PMC8928097, DOI: 10.1111/acer.14781.
• Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
• Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic eventsWendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.
• Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorderWendt FR, Pathak GA, Deak JD, De Angelis F, Koller D, Cabrera-Mendoza B, Lebovitch DS, Levey DF, Stein MB, Kranzler HR, Koenen KC, Gelernter J, Huckins LM, Polimanti R. Using phenotype risk scores to enhance gene discovery for generalized anxiety disorder and posttraumatic stress disorder Molecular Psychiatry 2022, 27: 2206-2215. PMID: 35181757, PMCID: PMC9133008, DOI: 10.1038/s41380-022-01469-y.
• Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veteransMontalvo-Ortiz JL, Gelernter J, Cheng Z, Girgenti MJ, Xu K, Zhang X, Gopalan S, Zhou H, Duman RS, Southwick SM, Krystal JH, Pietrzak R. Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans Translational Psychiatry 2022, 12: 65. PMID: 35177594, PMCID: PMC8854688, DOI: 10.1038/s41398-022-01822-3.
• Genome-wide meta-analysis of alcohol use disorder in East AsiansZhou H, Kalayasiri R, Sun Y, Nuñez YZ, Deng HW, Chen XD, Justice AC, Kranzler HR, Chang S, Lu L, Shi J, Sanichwankul K, Mutirangura A, Malison RT, Gelernter J. Genome-wide meta-analysis of alcohol use disorder in East Asians Neuropsychopharmacology 2022, 47: 1791-1797. PMID: 35094024, PMCID: PMC9372033, DOI: 10.1038/s41386-022-01265-w.
• Post‐treatment effects of topiramate on alcohol‐related outcomes: A combined analysis of two placebo‐controlled trialsKranzler HR, Feinn R, Pond T, Hartwell E, Gelernter J, Crist RC, Witkiewitz K. Post‐treatment effects of topiramate on alcohol‐related outcomes: A combined analysis of two placebo‐controlled trials Addiction Biology 2022, 27: e13130. PMID: 35229945, PMCID: PMC9257958, DOI: 10.1111/adb.13130.
• Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol useRattanasumawong W, Malison R, Gelernter J, Nunez Y, Kalayasiri R. Clinical and behavioral correlates in adult methamphetamine users with childhood exposure to household drug and alcohol use The International Journal Of Alcohol And Drug Research 2022, 9: 77-84. DOI: 10.7895/ijadr.345.
• Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic riskDe Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk Translational Psychiatry 2021, 11: 586. PMID: 34775470, PMCID: PMC8590689, DOI: 10.1038/s41398-021-01713-z.
• The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlatesHatoum AS, Johnson EC, Colbert SMC, Polimanti R, Zhou H, Walters RK, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates Neuropsychopharmacology 2021, 47: 1739-1745. PMID: 34750568, PMCID: PMC9372072, DOI: 10.1038/s41386-021-01209-w.
• Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veteransNa PJ, De Angelis F, Nichter B, Wendt FR, Krystal JH, Southwick SM, Levey DF, Gelernter J, Polimanti R, Pietrzak RH. Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of U.S. veterans Molecular Psychiatry 2021, 27: 1068-1074. PMID: 34725455, DOI: 10.1038/s41380-021-01352-2.
• Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an exampleHatoum AS, Wendt FR, Galimberti M, Polimanti R, Neale B, Kranzler HR, Gelernter J, Edenberg HJ, Agrawal A. Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example Drug And Alcohol Dependence 2021, 229: 109115. PMID: 34710714, PMCID: PMC9358969, DOI: 10.1016/j.drugalcdep.2021.109115.
• Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort StudyTamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.
• Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience 2021, 24: 1367-1376. PMID: 34446935, PMCID: PMC8484054, DOI: 10.1038/s41593-021-00908-3.
• COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERYWendt F, Pathak G, Deak J, De Angelis F, Koller D, Cabrera-Mendoza B, Levey D, Stein M, Kranzler H, Koenen K, Gelernter J, Huckins L, Polimanti R. COMORBID-PHENOME PREDICTION AND PHENOTYPE RISK SCORES INCREASE DATA AVAILABILITY FOR ANXIETY AND PTSD GENE DISCOVERY European Neuropsychopharmacology 2021, 51: e6-e7. DOI: 10.1016/j.euroneuro.2021.07.023.
• A COMPARISON OF THREE PHENOTYPE DEFINITIONS FOR MENTAL HEALTH CONDITIONS IN THE MILLION VETERAN PROGRAMHarrington K, Quaden R, Whitbourne S, Gelernter J, Stein M, Gaziano J. A COMPARISON OF THREE PHENOTYPE DEFINITIONS FOR MENTAL HEALTH CONDITIONS IN THE MILLION VETERAN PROGRAM European Neuropsychopharmacology 2021, 51: e6. DOI: 10.1016/j.euroneuro.2021.07.022.
• Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure InformationMaihofer AX, Choi KW, Coleman JRI, Daskalakis NP, Denckla CA, Ketema E, Morey RA, Polimanti R, Ratanatharathorn A, Torres K, Wingo AP, Zai CC, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegović E, Borglum AD, Babić D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Chen CY, Dale AM, Dalvie S, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Duncan LE, Džubur Kulenović A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gautam A, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goçi A, Gordon SD, Guffanti G, Hammamieh R, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljević M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller JL, Marmar C, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, Mehta D, Mellor R, Michopoulos V, Milberg W, Miller MW, Morris CP, Mors O, Mortensen PB, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Yehuda R, Young KA, Young RM, Zhao H, Zoellner LA, Haas M, Lasseter H, Provost AC, Salem RM, Sebat J, Shaffer RA, Wu T, Ripke S, Daly MJ, Ressler KJ, Koenen KC, Stein MB, Nievergelt CM. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information Biological Psychiatry 2021, 91: 626-636. PMID: 34865855, PMCID: PMC8917986, DOI: 10.1016/j.biopsych.2021.09.020.
• Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)Ma YJ, Wang YY, Liu MQ, Fang T, Wei ZR, Chen SB, Tan H, Nunez YZ, Zhang XJ, Hao W, Malison RT, Kranzler HR, Gelernter J, Liu TQ, Yang BZ. Reliability and validity of DSM-IV and DSM-5 methamphetamine use disorder diagnoses using the Chinese Version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Drug And Alcohol Dependence 2021, 229: 109047. PMID: 34710713, DOI: 10.1016/j.drugalcdep.2021.109047.
• Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and compositionCarvalho C, Wendt FR, Pathak GA, Maihofer AX, Stein DJ, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Disentangling sex differences in the shared genetic architecture of posttraumatic stress disorder, traumatic experiences, and social support with body size and composition Neurobiology Of Stress 2021, 15: 100400. PMID: 34611531, PMCID: PMC8477211, DOI: 10.1016/j.ynstr.2021.100400.
• Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk FactorsMullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, Levey DF, Lori A, Shabalin A, Starnawska A, Su MH, Watson HJ, Adams M, Awasthi S, Gandal M, Hafferty JD, Hishimoto A, Kim M, Okazaki S, Otsuka I, Ripke S, Ware EB, Bergen AW, Berrettini WH, Bohus M, Brandt H, Chang X, Chen WJ, Chen HC, Crawford S, Crow S, DiBlasi E, Duriez P, Fernández-Aranda F, Fichter MM, Gallinger S, Glatt SJ, Gorwood P, Guo Y, Hakonarson H, Halmi KA, Hwu HG, Jain S, Jamain S, Jiménez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Klump KL, Li D, Liao SC, Lieb K, Lilenfeld L, Liu CM, Magistretti PJ, Marshall CR, Mitchell JE, Monson ET, Myers RM, Pinto D, Powers A, Ramoz N, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Strober M, Thornton LM, Treasure J, Tsuang MT, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Air TM, Alda M, Alfredsson L, Andreassen OA, Anjorin A, Appadurai V, Artigas M, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Bosch R, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Casas M, Castelao E, Cervilla JA, Chaumette B, Cichon S, Corvin A, Craddock N, Craig D, Degenhardt F, Djurovic S, Edenberg HJ, Fanous AH, Foo JC, Forstner AJ, Frye M, Fullerton JM, Gatt JM, Gejman PV, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamilton SP, Hamshere ML, Hartmann A, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Konte B, Krebs MO, Landén M, Lawrence J, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Lucae S, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Medland SE, Mehta D, Melle I, Milaneschi Y, Mitchell PB, Molina E, Morken G, Mortensen PB, Müller-Myhsok B, Nievergelt C, Nimgaonkar V, Nöthen MM, O’Donovan M, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Pimm J, Pistis G, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribasés M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Rujescu D, Sánchez-Mora C, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Shyn SI, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Spalletta G, Strauss JS, Świątkowska B, Trzaskowski M, Turecki G, Vilar-Ribó L, Vincent JB, Völzke H, Walters JTR, Weickert C, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Ashley-Koch AE, Beckham JC, Hauser ER, Hauser MA, Kimbrel NA, Lindquist JH, McMahon B, Oslin DW, Qin X, Agerbo E, Børglum A, Breen G, Erlangsen A, Esko T, Gelernter J, Hougaard D, Kessler R, Kranzler H, Li Y, Martin N, McIntosh A, Mors O, Nordentoft M, Olsen C, Porteous D, Ursano R, Wasserman D, Werge T, Whiteman D, Bulik C, Coon H, Demontis D, Docherty A, Kuo P, 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Kretzschmar W, Kutalik Z, Li Q, Lind P, MacIntyre D, MacKinnon D, Maier R, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland S, Mehta D, Middeldorp C, Mihailov E, Milaneschi Y, Milani L, Mondimore F, Montgomery G, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard M, Nyholt D, O’Reilly P, Oskarsson H, Hayward C, Heath A, Kendler K, Kloiber S, Lewis C, Li D, Lucae S, Madden P, Magnusson P, Martin N, McIntosh A, Metspalu A, Mors O, Mortensen P, Müller-Myhsok B, Nordentoft M, Nöthen M, O’Donovan M, Paciga S, Pedersen N, Owen M, Painter J, Pedersen C, Pedersen M, Peterson R, Peyrot W, Pistis G, Posthuma D, Quiroz J, Qvist P, Rice J, Riley B, Rivera M, Mirza S, Schoevers R, Schulte E, Shen L, Shi J, Shyn S, Sigurdsson E, Sinnamon G, Smit J, Smith D, Stefansson H, Steinberg S, Streit F, Strohmaier J, Tansey K, Teismann H, Teumer A, Thompson W, Thomson P, Thorgeirsson T, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden A, Umbricht D, Van der Auwera S, van Hemert A, Viktorin A, 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• Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depressionStein MB, Jain S, Campbell‐Sills L, Ware EB, Choi KW, He F, Ge T, Gelernter J, Smoller JW, Kessler RC, Ursano RJ. Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2021, 186: 469-475. PMID: 34288400, PMCID: PMC8692314, DOI: 10.1002/ajmg.b.32868.
• Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.Johnson EC, Kapoor M, Hatoum AS, Zhou H, Polimanti R, Wendt FR, Walters RK, Lai D, Kember RL, Hartz S, Meyers JL, Peterson RE, Ripke S, Bigdeli TB, Fanous AH, Pato CN, Pato MT, Goate AM, Kranzler HR, O'Donovan MC, Walters JTR, Gelernter J, Edenberg HJ, Agrawal A. Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. Psychological Medicine 2021, 1-9. PMID: 34231451, PMCID: PMC8738774, DOI: 10.1017/s003329172100266x.
• Genome-wide association study of stimulant dependenceCox J, Sherva R, Wetherill L, Foroud T, Edenberg HJ, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of stimulant dependence Translational Psychiatry 2021, 11: 363. PMID: 34226506, PMCID: PMC8257618, DOI: 10.1038/s41398-021-01440-5.
• Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006Radhakrishnan K, Hauser ER, Polimanti R, Helmer DA, Provenzale D, McNeil RB, Maffucci A, Quaden R, Zhao H, Whitbourne SB, Harrington KM, Vahey J, Gelernter J, Levey DF, Huang GD, Gaziano JM, Concato J, Aslan M. Genomics of Gulf War Illness in U.S. Veterans Who Served during the 1990–1991 Persian Gulf War: Methods and Rationale for Veterans Affairs Cooperative Study #2006 Brain Sciences 2021, 11: 845. PMID: 34202057, PMCID: PMC8301942, DOI: 10.3390/brainsci11070845.
• Integration of evidence across human and model organism studies: A meeting reportPalmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca‐Bachman C, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Bin Kwon S, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez‐Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. Integration of evidence across human and model organism studies: A meeting report Genes Brain & Behavior 2021, 20: e12738. PMID: 33893716, PMCID: PMC8365690, DOI: 10.1111/gbb.12738.
• Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorderMundy J, Hübel C, Gelernter J, Levey D, Murray RM, Skelton M, Stein MB, Program P, Vassos E, Breen G, Coleman J. Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder Psychological Medicine 2021, 52: 1-10. PMID: 34085609, PMCID: PMC8962503, DOI: 10.1017/s0033291721000830.
• Combined Analysis of the Moderating Effect of a GRIK1 Polymorphism on the Effects of Topiramate for Treating Alcohol Use DisorderKranzler HR, Hartwell EE, Feinn R, Pond T, Witkiewitz K, Gelernter J, Crist RC. Combined Analysis of the Moderating Effect of a GRIK1 Polymorphism on the Effects of Topiramate for Treating Alcohol Use Disorder Drug And Alcohol Dependence 2021, 225: 108762. PMID: 34049101, PMCID: PMC8282735, DOI: 10.1016/j.drugalcdep.2021.108762.
• Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment styleAsch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH. Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style The World Journal Of Biological Psychiatry 2021, 22: 792-799. PMID: 33821766, PMCID: PMC8925016, DOI: 10.1080/15622975.2021.1907721.
• The relationship between cannabis and schizophrenia: a genetically informed perspectiveJohnson EC, Hatoum AS, Deak JD, Polimanti R, Murray RM, Edenberg HJ, Gelernter J, Di Forti M, Agrawal A. The relationship between cannabis and schizophrenia: a genetically informed perspective Addiction 2021, 116: 3227-3234. PMID: 33950550, PMCID: PMC8492483, DOI: 10.1111/add.15534.
• Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biologyMullins N, Forstner AJ, O’Connell K, Coombes B, Coleman JRI, Qiao Z, Als TD, Bigdeli TB, Børte S, Bryois J, Charney AW, Drange OK, Gandal MJ, Hagenaars SP, Ikeda M, Kamitaki N, Kim M, Krebs K, Panagiotaropoulou G, Schilder BM, Sloofman LG, Steinberg S, Trubetskoy V, Winsvold BS, Won HH, Abramova L, Adorjan K, Agerbo E, Al Eissa M, Albani D, Alliey-Rodriguez N, Anjorin A, Antilla V, Antoniou A, Awasthi S, Baek JH, Bækvad-Hansen M, Bass N, Bauer M, Beins EC, Bergen SE, Birner A, Bøcker Pedersen C, Bøen E, Boks MP, Bosch R, Brum M, Brumpton BM, Brunkhorst-Kanaan N, Budde M, Bybjerg-Grauholm J, Byerley W, Cairns M, Casas M, Cervantes P, Clarke TK, Cruceanu C, Cuellar-Barboza A, Cunningham J, Curtis D, Czerski PM, Dale AM, Dalkner N, David FS, Degenhardt F, Djurovic S, Dobbyn AL, Douzenis A, Elvsåshagen T, Escott-Price V, Ferrier IN, Fiorentino A, Foroud TM, Forty L, Frank J, Frei O, Freimer NB, Frisén L, Gade K, Garnham J, Gelernter J, Giørtz Pedersen M, Gizer IR, Gordon SD, Gordon-Smith K, Greenwood TA, Grove J, Guzman-Parra J, Ha K, Haraldsson M, Hautzinger M, Heilbronner U, Hellgren D, Herms S, Hoffmann P, Holmans PA, Huckins L, Jamain S, Johnson JS, Kalman JL, Kamatani Y, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koromina M, Kranz TM, Kranzler HR, Kubo M, Kupka R, Kushner SA, Lavebratt C, Lawrence J, Leber M, Lee HJ, Lee PH, Levy SE, Lewis C, Liao C, Lucae S, Lundberg M, MacIntyre DJ, Magnusson SH, Maier W, Maihofer A, Malaspina D, Maratou E, Martinsson L, Mattheisen M, McCarroll SA, McGregor NW, McGuffin P, McKay JD, Medeiros H, Medland SE, Millischer V, Montgomery GW, Moran JL, Morris DW, Mühleisen TW, O’Brien N, O’Donovan C, Olde Loohuis LM, Oruc L, Papiol S, Pardiñas AF, Perry A, Pfennig A, Porichi E, Potash JB, Quested D, Raj T, Rapaport MH, DePaulo JR, Regeer EJ, Rice JP, Rivas F, Rivera M, Roth J, Roussos P, Ruderfer DM, Sánchez-Mora C, Schulte EC, Senner F, Sharp S, Shilling PD, Sigurdsson E, Sirignano L, Slaney C, Smeland OB, Smith DJ, Sobell JL, Søholm Hansen C, Soler Artigas M, Spijker AT, Stein DJ, Strauss JS, Świątkowska B, Terao C, Thorgeirsson TE, Toma C, Tooney P, Tsermpini EE, Vawter MP, Vedder H, Walters JTR, Witt SH, Xi S, Xu W, Yang JMK, Young AH, Young H, Zandi PP, Zhou H, Zillich L, Adolfsson R, Agartz I, Alda M, Alfredsson L, Babadjanova G, Backlund L, Baune B, Bellivier F, Bengesser S, Berrettini W, Blackwood D, Boehnke M, Børglum A, Breen G, Carr V, Catts S, Corvin A, Craddock N, Dannlowski U, Dikeos D, Esko T, Etain B, Ferentinos P, Frye M, Fullerton J, Gawlik M, Gershon E, Goes F, Green M, Grigoroiu-Serbanescu M, Hauser J, Henskens F, Hillert J, Hong K, Hougaard D, Hultman C, Hveem K, Iwata N, Jablensky A, Jones I, Jones L, Kahn R, Kelsoe J, Kirov G, Landén M, Leboyer M, Lewis C, Li Q, Lissowska J, Lochner C, Loughland C, Martin N, Mathews C, Mayoral F, McElroy S, McIntosh A, McMahon F, Melle I, Michie P, Milani L, Mitchell P, Morken G, Mors O, Mortensen P, Mowry B, Müller-Myhsok B, Myers R, Neale B, Nievergelt C, Nordentoft M, Nöthen M, O’Donovan M, Oedegaard K, Olsson T, Owen M, Paciga S, Pantelis C, Pato C, Pato M, Patrinos G, Perlis R, Posthuma D, Ramos-Quiroga J, Reif A, Reininghaus E, Ribasés M, Rietschel M, Ripke S, Rouleau G, Saito T, Schall U, Schalling M, Schofield P, Schulze T, Scott L, Scott R, Serretti A, Shannon Weickert C, Smoller J, Stefansson H, Stefansson K, Stordal E, Streit F, Sullivan P, Turecki G, Vaaler A, Vieta E, Vincent J, Waldman I, Weickert T, Werge T, Wray N, Zwart J, Biernacka J, Nurnberger J, Cichon S, Edenberg H, Stahl E, McQuillin A, Di Florio A, Ophoff R, Andreassen O. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology Nature Genetics 2021, 53: 817-829. PMID: 34002096, PMCID: PMC8192451, DOI: 10.1038/s41588-021-00857-4.
• The impact of removing former drinkers from genome‐wide association studies of AUDIT‐CDao C, Zhou H, Small A, Gordon KS, Li B, Kember RL, Ye Y, Gelernter J, Xu K, Kranzler HR, Zhao H, Justice AC. The impact of removing former drinkers from genome‐wide association studies of AUDIT‐C Addiction 2021, 116: 3044-3054. PMID: 33861876, PMCID: PMC9377185, DOI: 10.1111/add.15511.
• Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypesCampbell-Sills L, Sun X, Choi KW, He F, Ursano RJ, Kessler RC, Levey DF, Smoller JW, Gelernter J, Jain S, Stein MB. Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes Psychological Medicine 2021, 52: 3646-3654. PMID: 33947479, PMCID: PMC9772910, DOI: 10.1017/s0033291721000428.
• Differential Methylation and Co-Methylation Analysis Reveals Functional Targets of Major Depressive Disorder in WomenMontalvo-Ortiz J, Nagamatsu S, Cheng Z, Kranzler H, Gelernter J. Differential Methylation and Co-Methylation Analysis Reveals Functional Targets of Major Depressive Disorder in Women Biological Psychiatry 2021, 89: s382. DOI: 10.1016/j.biopsych.2021.02.949.
• Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD PathogenesisWingo T, Gerasimov E, Liu Y, Duong D, Lori A, Gockley J, Toikumo S, Breen M, Maihofer A, Nievergelt C, Koenen K, Ressler K, Levey D, Gelernter J, Stein M, Bennett D, Levey A, Seyfried N, Wingo A. Integrating Human Brain Proteomes With Genome-Wide Association Results Identify Novel Brain Proteins in PTSD Pathogenesis Biological Psychiatry 2021, 89: s102-s103. DOI: 10.1016/j.biopsych.2021.02.265.
• Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression.Pathak GA, Wendt FR, Levey DF, Mecca AP, van Dyck CH, Gelernter J, Polimanti R. Pleiotropic effects of telomere length loci with brain morphology and brain tissue expression. Human Molecular Genetics 2021, 30: 1360-1370. PMID: 33831179, PMCID: PMC8255129, DOI: 10.1093/hmg/ddab102.
• Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genesSherva R, Zhu C, Wetherill L, Edenberg HJ, Johnson E, Degenhardt L, Agrawal A, Martin NG, Nelson E, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes Exploration Of Medicine 2021, 2: 60-73. PMID: 34124712, PMCID: PMC8192073, DOI: 10.37349/emed.2021.00032.
• Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genesSherva R, Zhu C, Wetherill L, Edenberg H, Johnson E, Degenhardt L, Agrawal A, Martin N, Nelson E, Kranzler H, Gelernter J, Farrer L. Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes Exploration Of Medicine 2021 DOI: 10.37349/emed.2020.00032.
• Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidalityWendt FR, Pathak GA, Levey DF, Nuñez YZ, Overstreet C, Tyrrell C, Adhikari K, De Angelis F, Tylee DS, Goswami A, Krystal JH, Abdallah CG, Stein MB, Kranzler HR, Gelernter J, Polimanti R. Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality Neurobiology Of Stress 2021, 14: 100309. PMID: 33665242, PMCID: PMC7905234, DOI: 10.1016/j.ynstr.2021.100309.
• Prevalence of predicted gene-drug interactions for antidepressants in the treatment of major depressive disorder in the Precision Medicine in Mental Health Care StudyRamsey CM, Lynch KG, Thase ME, Gelernter J, Kranzler HR, Pyne JM, Shih MC, Stone A, Committee C, Oslin DW. Prevalence of predicted gene-drug interactions for antidepressants in the treatment of major depressive disorder in the Precision Medicine in Mental Health Care Study Journal Of Affective Disorders 2021, 282: 1272-1277. PMID: 33601706, DOI: 10.1016/j.jad.2021.01.034.
• Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidalityPolimanti R, Levey DF, Pathak GA, Wendt FR, Nunez YZ, Ursano RJ, Kessler RC, Kranzler HR, Stein MB, Gelernter J. Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality Translational Psychiatry 2021, 11: 34. PMID: 33431810, PMCID: PMC7801457, DOI: 10.1038/s41398-020-01153-1.
• Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid MechanismsPathak GA, Wendt FR, De Lillo A, Nunez YZ, Goswami A, De Angelis F, Fuciarelli M, Kranzler HR, Gelernter J, Polimanti R. Epigenomic Profiles of African-American Transthyretin Val122Ile Carriers Reveals Putatively Dysregulated Amyloid Mechanisms Circulation Genomic And Precision Medicine 2021, 14: e003011. PMID: 33428857, PMCID: PMC7887108, DOI: 10.1161/circgen.120.003011.
• Multivariate genome-wide analysis of education, socioeconomic status and brain phenomeWendt FR, Pathak GA, Lencz T, Krystal JH, Gelernter J, Polimanti R. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome Nature Human Behaviour 2020, 5: 482-496. PMID: 33349686, PMCID: PMC8068566, DOI: 10.1038/s41562-020-00980-y.
• Transcriptomic organization of the human brain in post-traumatic stress disorderGirgenti MJ, Wang J, Ji D, Cruz DA, Stein M, Gelernter J, Young K, Huber B, Williamson D, Friedman M, Krystal J, Zhao H, Duman R. Transcriptomic organization of the human brain in post-traumatic stress disorder Nature Neuroscience 2020, 24: 24-33. PMID: 33349712, DOI: 10.1038/s41593-020-00748-7.
• Study design and implementation of the PRecision Medicine In MEntal health Care (PRIME Care) TrialOslin DW, Chapman S, Duvall SL, Gelernter J, Ingram E, Kranzler HR, Lehmann LS, Lynch JA, Lynch KG, Pyne JM, Shih MC, Stone A, Thase ME, Wray LO. Study design and implementation of the PRecision Medicine In MEntal health Care (PRIME Care) Trial Contemporary Clinical Trials 2020, 101: 106247. PMID: 33316457, DOI: 10.1016/j.cct.2020.106247.
• Characterizing the effect of background selection on the polygenicity of brain-related traitsWendt FR, Pathak GA, Overstreet C, Tylee DS, Gelernter J, Atkinson EG, Polimanti R. Characterizing the effect of background selection on the polygenicity of brain-related traits Genomics 2020, 113: 111-119. PMID: 33278486, PMCID: PMC7855394, DOI: 10.1016/j.ygeno.2020.11.032.
• Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.Quach BC, Bray MJ, Gaddis NC, Liu M, Palviainen T, Minica CC, Zellers S, Sherva R, Aliev F, Nothnagel M, Young KA, Marks JA, Young H, Carnes MU, Guo Y, Waldrop A, Sey NYA, Landi MT, McNeil DW, Drichel D, Farrer LA, Markunas CA, Vink JM, Hottenga JJ, Iacono WG, Kranzler HR, Saccone NL, Neale MC, Madden P, Rietschel M, Marazita ML, McGue M, Won H, Winterer G, Grucza R, Dick DM, Gelernter J, Caporaso NE, Baker TB, Boomsma DI, Kaprio J, Hokanson JE, Vrieze S, Bierut LJ, Johnson EO, Hancock DB. Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Nature Communications 2020, 11: 5562. PMID: 33144568, PMCID: PMC7642344, DOI: 10.1038/s41467-020-19265-z.
• Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individualsXu K, Li B, McGinnis KA, Vickers-Smith R, Dao C, Sun N, Kember RL, Zhou H, Becker WC, Gelernter J, Kranzler HR, Zhao H, Justice AC. Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals Nature Communications 2020, 11: 5302. PMID: 33082346, PMCID: PMC7598939, DOI: 10.1038/s41467-020-18489-3.
• A large-scale genome-wide association study meta-analysis of cannabis use disorderJohnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Workgroup P, Walters R, Polimanti R, Johnson E, McClintick J, Hatoum A, He J, Wendt F, Zhou H, Adams M, Adkins A, Aliev F, Bacanu S, Batzler A, Bertelsen S, Biernacka J, Bigdeli T, Chen L, Clarke T, Chou Y, Degenhardt F, Docherty A, Edwards A, Fontanillas P, Foo J, Fox L, Frank J, Giegling I, Gordon S, Hack L, Hartmann A, Hartz S, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffman P, Hottenga J, Kennedy M, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher B, Mbarek H, McIntosh A, McQueen M, Meyers J, Milaneschi Y, Palviainen T, Pearson J, Peterson R, Ripatti S, Ryu E, Saccone N, Salvatore J, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang J, Webb B, Wedow R, Wetherill L, Wills A, Boardman J, Chen D, Choi D, Copeland W, Culverhouse R, Dahmen N, Degenhardt L, Domingue B, Elson S, Frye M, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey M, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray A, Nurnberger J, Palotie A, Preuss U, Räikkönen K, Reynolds M, Ridinger M, Scherbaum N, Schuckit M, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins D, Boden J, Boomsma D, Bierut L, Brown S, Bucholz K, Cichon S, Costello E, de Wit H, Diazgranados N, Dick D, Eriksson J, Farrer L, Foroud T, Gillespie N, Goate A, Goldman D, Grucza R, Hancock D, Harris K, Heath A, Hesselbrock V, Hewitt J, Hopfer C, Horwood J, Iacono W, Johnson E, Kaprio J, Karpyak V, Kendler K, Kranzler H, Krauter K, Lichtenstein P, Lind P, McGue M, MacKillop J, Madden P, Maes H, Magnusson P, Martin N, Medland S, Montgomery G, Nelson E, Nöthen M, Palmer A, Pederson N, Penninx B, Porjesz B, Rice J, Rietschel M, Riley B, Rose R, Rujescu D, Shen P, Silberg J, Stallings M, Tarter R, Vanyukov M, Vrieze S, Wall T, Whitfield J, Zhao H, Neale B, Gelernter J, Edenberg H, Agrawal A, Davis L, Bogdan R, Gelernter J, Edenberg H, Stefansson K, Børglum A, Agrawal A. A large-scale genome-wide association study meta-analysis of cannabis use disorder The Lancet Psychiatry 2020, 7: 1032-1045. PMID: 33096046, PMCID: PMC7674631, DOI: 10.1016/s2215-0366(20)30339-4.
• GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individualsYang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals Addictive Behaviors 2020, 114: 106695. PMID: 33153773, PMCID: PMC8299472, DOI: 10.1016/j.addbeh.2020.106695.
• Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans StudyTamman AJF, Wendt FR, Pathak GA, Krystal JH, Montalvo-Ortiz JL, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Posttraumatic Stress in United States Military Veterans: Results From the National Health and Resilience in Veterans Study Biological Psychiatry 2020, 89: 878-887. PMID: 33276944, DOI: 10.1016/j.biopsych.2020.09.018.
• Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohortWendt FR, Carvalho CM, Pathak GA, Gelernter J, Polimanti R. Polygenic risk for autism spectrum disorder associates with anger recognition in a neurodevelopment-focused phenome-wide scan of unaffected youths from a population-based cohort PLOS Genetics 2020, 16: e1009036. PMID: 32941431, PMCID: PMC7523983, DOI: 10.1371/journal.pgen.1009036.
• Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese VersionYang BZ, Wang LJ, Huang MC, Wang SC, Tsai MC, Huang YC, Nuñez YZ, Ng MH, Kranzler HR, Gelernter J, Chen CK. Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version Complex Psychiatry 2020, 6: 62-67. PMID: 34882761, PMCID: PMC7923924, DOI: 10.1159/000511606.
• Introducing Complex PsychiatryGelernter J, Polimanti R. Introducing Complex Psychiatry Complex Psychiatry 2020, 6: 2-4. PMID: 34883505, PMCID: PMC7673582, DOI: 10.1159/000508645.
• Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 IndividualsPolimanti R, Wendt F, Tcheandjieu C, Hilliard A, Levey D, Cheng Z, O’Donnell C, Stein M, Assimes T, Gelernter J. Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 Individuals Biological Psychiatry 2020, 87: s52-s53. DOI: 10.1016/j.biopsych.2020.02.158.
• Genotyping Array Design and Data Quality Control in the Million Veteran ProgramHunter-Zinck H, Shi Y, Li M, Gorman BR, Ji SG, Sun N, Webster T, Liem A, Hsieh P, Devineni P, Karnam P, Gong X, Radhakrishnan L, Schmidt J, Assimes TL, Huang J, Pan C, Humphries D, Brophy M, Moser J, Muralidhar S, Huang GD, Przygodzki R, Concato J, Gaziano JM, Gelernter J, O’Donnell C, Hauser ER, Zhao H, O’Leary T, Program V, Tsao PS, Pyarajan S. Genotyping Array Design and Data Quality Control in the Million Veteran Program American Journal Of Human Genetics 2020, 106: 535-548. PMID: 32243820, PMCID: PMC7118558, DOI: 10.1016/j.ajhg.2020.03.004.
• Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social supportMuniz Carvalho C, Wendt FR, Maihofer AX, Stein DJ, Stein MB, Sumner JA, Hemmings SMJ, Nievergelt CM, Koenen KC, Gelernter J, Belangero SI, Polimanti R. Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support Neuropsychopharmacology 2020, 46: 1071-1077. PMID: 32179874, PMCID: PMC8115274, DOI: 10.1038/s41386-020-0655-6.
• Identifying factors associated with opioid cessation in a biracial sample using machine learningCox JW, Sherva RM, Lunetta KL, Saitz R, Kon M, Kranzler HR, Gelernter J, Farrer LA. Identifying factors associated with opioid cessation in a biracial sample using machine learning Exploration Of Medicine 2020, 1: 27-41. PMID: 33554217, PMCID: PMC7861053, DOI: 10.37349/emed.2020.00003.
• Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics ConsortiumPolimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfer CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Maes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L, Edenberg H, Agrawal A, Gelernter J. Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium Molecular Psychiatry 2020, 25: 1673-1687. PMID: 32099098, PMCID: PMC7392789, DOI: 10.1038/s41380-020-0677-9.
• A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interactionSun J, Kranzler HR, Gelernter J, Bi J. A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction Journal Of Psychiatry And Neuroscience 2020, 45: 34-44. PMID: 31490055, PMCID: PMC6919916, DOI: 10.1503/jpn.180098.
• Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric DisordersConsortium C, Lee P, Anttila V, Won H, Feng Y, Rosenthal J, Zhu Z, Tucker-Drob E, Nivard M, Grotzinger A, Posthuma D, Wang M, Yu D, Stahl E, Walters R, Anney R, Duncan L, Ge T, Adolfsson R, Banaschewski T, Belangero S, Cook E, Coppola G, Derks E, Hoekstra P, Kaprio J, Keski-Rahkonen A, Kirov G, Kranzler H, Luykx J, Rohde L, Zai C, Agerbo E, Arranz M, Asherson P, Bækvad-Hansen M, Baldursson G, Bellgrove M, Belliveau R, Buitelaar J, Burton C, Bybjerg-Grauholm J, Casas M, Cerrato F, Chambert K, Churchhouse C, Cormand B, Crosbie J, Dalsgaard S, Demontis D, Doyle A, Dumont A, Elia J, Grove J, Gudmundsson O, Haavik J, Hakonarson H, Hansen C, Hartman C, Hawi Z, Hervás A, Hougaard D, Howrigan D, Huang H, Kuntsi J, Langley K, Lesch K, Leung P, Loo S, Martin J, Martin A, McGough J, Medland S, Moran J, Mors O, Mortensen P, Oades R, Palmer D, Pedersen C, Pedersen M, Peters T, Poterba T, Poulsen J, Ramos-Quiroga J, Reif A, Ribasés M, Rothenberger A, Rovira P, Sánchez-Mora C, Satterstrom F, Schachar R, Artigas M, Steinberg S, Stefansson H, Turley P, Walters G, Team 2, Werge T, Zayats T, Arking D, Bettella F, Buxbaum J, Christensen J, Collins R, Coon H, De Rubeis S, Delorme R, Grice D, Hansen T, Holmans P, Hope S, Hultman C, Klei L, Ladd-Acosta C, Magnusson P, Nærland T, Nyegaard M, Pinto D, Qvist P, Rehnström K, Reichenberg A, Reichert J, Roeder K, Rouleau G, Saemundsen E, Sanders S, Sandin S, St Pourcain B, Stefansson K, Sutcliffe J, Talkowski M, Weiss L, Willsey A, Agartz I, Akil H, Albani D, Alda M, Als T, Anjorin A, Backlund L, Bass N, Bauer M, Baune B, Bellivier F, Bergen S, Berrettini W, Biernacka J, Blackwood D, Bøen E, Budde M, Bunney W, Burmeister M, Byerley W, Byrne E, Cichon S, Clarke T, Coleman J, Craddock N, Curtis D, Czerski P, Dale A, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Elvsåshagen T, Etain B, Fischer S, Forstner A, Forty L, Frank J, Frye M, Fullerton J, Gade K, Gaspar H, Gershon E, Gill M, Goes F, Gordon S, Gordon-Smith K, Green M, Greenwood T, Grigoroiu-Serbanescu M, Guzman-Parra J, Hauser J, Hautzinger M, Heilbronner U, Herms S, Hoffmann P, Holland D, Jamain S, Jones I, Jones L, Kandaswamy R, Kelsoe J, Kennedy J, Joachim O, Kittel-Schneider S, Kogevinas M, Koller A, Lavebratt C, Lewis C, Li Q, Lissowska J, Loohuis L, Lucae S, Maaser A, Malt U, Martin N, Martinsson L, McElroy S, McMahon F, McQuillin A, Melle I, Metspalu A, Millischer V, Mitchell P, Montgomery G, Morken G, Morris D, Müller-Myhsok B, Mullins N, Myers R, Nievergelt C, Nordentoft M, Adolfsson A, Nöthen M, Ophoff R, Owen M, Paciga S, Pato C, Pato M, Perlis R, Perry A, Potash J, Reinbold C, Rietschel M, Rivera M, Roberson M, Schalling M, Schofield P, Schulze T, Scott L, Serretti A, Sigurdsson E, Smeland O, Stordal E, Streit F, Strohmaier J, Thorgeirsson T, Treutlein J, Turecki G, Vaaler A, Vieta E, Vincent J, Wang Y, Witt S, Zandi P, Adan R, Alfredsson L, Ando T, Aschauer H, Baker J, Bencko V, Bergen A, Birgegård A, Perica V, Brandt H, Burghardt R, Carlberg L, Cassina M, Clementi M, Courtet P, Crawford S, Crow S, Crowley J, Danner U, Davis O, Degortes D, DeSocio J, Dick D, Dina C, Docampo E, Egberts K, Ehrlich S, Espeseth T, Fernández-Aranda F, Fichter M, Foretova L, Forzan M, Gambaro G, Giegling I, Gonidakis F, Gorwood P, Mayora M, Guo Y, Halmi K, Hatzikotoulas K, Hebebrand J, Helder S, Herpertz-Dahlmann B, Herzog W, Hinney A, Imgart H, Jiménez-Murcia S, Johnson C, Jordan J, Julià A, Kaminská D, Karhunen L, Karwautz A, Kas M, Kaye W, Kennedy M, Kim Y, Klareskog L, Klump K, Knudsen G, Landén M, Le Hellard S, Levitan R, Li D, Lichtenstein P, Maj M, Marsal S, McDevitt S, Mitchell J, Monteleone P, Monteleone A, Munn-Chernoff M, Nacmias B, Navratilova M, O’Toole J, Padyukov L, Pantel J, Papezova H, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Roberts M, Rujescu D, Rybakowski F, Scherag A, Schmidt U, Seitz J, Slachtova L, Landt M, Slopien A, Sorbi S, Southam L, Strober M, Tortorella A, Tozzi F, Treasure J, Tziouvas K, van Elburg A, Wade T, Wagner G, Walton E, Watson H, Wichmann H, Woodside D, Zeggini E, Zerwas S, Zipfel S, Adams M, Andlauer T, Berger K, Binder E, Boomsma D, Castelao E, Colodro-Conde L, Direk N, Docherty A, Domenici E, Domschke K, Dunn E, Foo J, de. Geus E, Grabe H, Hamilton S, Horn C, Hottenga J, Howard D, Ising M, Kloiber S, Levinson D, Lewis G, Magnusson P, Mbarek H, Middeldorp C, Mostafavi S, Nyholt D, Penninx B, Peterson R, Pistis G, Porteous D, Preisig M, Quiroz J, Schaefer C, Schulte E, Shi J, Smith D, Thomson P, Tiemeier H, Uher R, van der Auwera S, Weissman M, Alexander M, Begemann M, Bramon E, Buccola N, Cairns M, Campion D, Carr V, Cloninger C, Cohen D, Collier D, Corvin A, DeLisi L, Donohoe G, Dudbridge F, Duan J, Freedman R, Gejman P, Golimbet V, Godard S, Ehrenreich H, Hartmann A, Henskens F, Ikeda M, Iwata N, Jablensky A, Joa I, Jönsson E, Kelly B, Knight J, Konte B, Laurent-Levinson C, Lee J, Lencz T, Lerer B, Loughland C, Malhotra A, Mallet J, McDonald C, Mitjans M, Mowry B, Murphy K, Murray R, O’Neill F, Oh S, Palotie A, Pantelis C, Pulver A, Consortium P, Petryshen T, Quested D, Riley B, Sanders A, Schall U, Schwab S, Scott R, Sham P, Silverman J, Sim K, Steixner A, Tooney P, van Os J, Vawter P, Walsh D, Weiser M, Wildenauer D, Williams N, Wormley B, Consortium W, Zhang F, Androutsos C, Arnold P, Barr C, Barta C, Bey K, Bienvenu O, Black D, Brown L, Budman C, Cath D, Cheon K, Ciullo V, Coffey B, Cusi D, Davis L, Denys D, Depienne C, Dietrich A, Eapen V, Falkai P, Fernandez T, Garcia-Delgar B, Geller D, Gilbert D, Grados M, Greenberg E, Grünblatt E, Hagstrøm J, Hanna G, Hartmann A, Hedderly T, Heiman G, Heyman I, Hong H, Huang A, Huyser C, Ibanez-Gomez L, Khramtsova E, Kim Y, Kim Y, King R, Koh Y, Konstantinidis A, Kook S, Kuperman S, Leventhal B, Lochner C, Ludolph A, Madruga-Garrido M, Malaty I, Maras A, McCracken J, Meijer I, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy T, Naarden A, Nagy P, Nestadt G, Nestadt P, Nicolini H, Nurmi E, Okun M, Paschou P, Piras F, Piras F, Pittenger C, Plessen K, Richter M, Rizzo R, Robertson M, Roessner V, Ruhrmann S, Samuels J, Sandor P, Schlögelhofer M, Shin E, Singer H, Song D, Song J, Spalletta G, Stein D, Stewart S, Storch E, Stranger B, Stuhrmann M, Tarnok Z, Tischfield J, Tübing J, Visscher F, Vulink N, Wagner M, Walitza S, Wanderer S, Woods M, Worbe Y, Zai G, Zinner S, Sullivan P, Franke B, Daly M, Bulik C, McIntosh A, O’Donovan M, Zheutlin A, Andreassen O, Børglum A, Breen G, Edenberg H, Fanous A, Faraone S, Gelernter J, Mathews C, Mattheisen M, Mitchell K, Neale M, Nurnberger J, Ripke S, Santangelo S, Scharf J, Stein M, Thornton L, Walters J, Wray N, Geschwind D, Neale B, Kendler K, Smoller J. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders Cell 2019, 179: 1469-1482.e11. PMID: 31835028, PMCID: PMC7077032, DOI: 10.1016/j.cell.2019.11.020.
• GENOMIC CHARACTERIZATION OF POSTTRAUMATIC STRESS DISORDER IN A LARGE (N) MULTI-POPULATION U.S. MILITARY VETERAN SAMPLEStein M, Levey D, Polimanti R, Cheng Z, Harrington K, Radhakrishnan K, Aslan M, Concato J, Group M, Gelernter J. GENOMIC CHARACTERIZATION OF POSTTRAUMATIC STRESS DISORDER IN A LARGE (N) MULTI-POPULATION U.S. MILITARY VETERAN SAMPLE European Neuropsychopharmacology 2019, 29: s43. DOI: 10.1016/j.euroneuro.2019.07.085.
• GENOME-WIDE ASSOCIATION STUDY OF CANNABIS USE DISORDER IN EUROPEAN AND AFRICAN ANCESTRIESJohnson E, Demontis D, Polimanti R, Walters R, McClintick J, Workgroup P, Edenberg H, Gelernter J, Børglum A, Agrawal A. GENOME-WIDE ASSOCIATION STUDY OF CANNABIS USE DISORDER IN EUROPEAN AND AFRICAN ANCESTRIES European Neuropsychopharmacology 2019, 29: s10-s11. DOI: 10.1016/j.euroneuro.2019.07.022.
• Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populationsKranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations Nature Communications 2019, 10: 4050. PMID: 31481659, PMCID: PMC6722074, DOI: 10.1038/s41467-019-11916-0.
• Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male VeteransXu K, Montalvo‐Ortiz J, Zhang X, Southwick SM, Krystal JH, Pietrzak RH, Gelernter J. Epigenome‐Wide DNA Methylation Association Analysis Identified Novel Loci in Peripheral Cells for Alcohol Consumption Among European American Male Veterans Alcoholism Clinical And Experimental Research 2019, 43: 2111-2121. PMID: 31386212, PMCID: PMC9377208, DOI: 10.1111/acer.14168.
• Differentiating Types of Self-Reported Alcohol AbstinenceGordon KS, McGinnis K, Dao C, Rentsch CT, Small A, Smith RV, Kember RL, Gelernter J, Kranzler HR, Bryant KJ, Tate JP, Justice AC. Differentiating Types of Self-Reported Alcohol Abstinence AIDS And Behavior 2019, 24: 655-665. PMID: 31435887, PMCID: PMC6994373, DOI: 10.1007/s10461-019-02638-x.
• Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans StudyAverill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.
• Genome‐wide scan identifies opioid overdose risk locus close to MCOLN1Cheng Z, Yang B, Zhou H, Nunez Y, Kranzler HR, Gelernter J. Genome‐wide scan identifies opioid overdose risk locus close to MCOLN1 Addiction Biology 2019, 25: e12811. PMID: 31362332, PMCID: PMC7485539, DOI: 10.1111/adb.12811.
• Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veteransGelernter J, Sun N, Polimanti R, Pietrzak R, Levey DF, Bryois J, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Pyarajan S, Sullivan PF, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Concato J, Zhao H, Stein MB. Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans Nature Neuroscience 2019, 22: 1394-1401. PMID: 31358989, PMCID: PMC6953633, DOI: 10.1038/s41593-019-0447-7.
• Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort StudyRentsch CT, Edelman EJ, Justice AC, Marshall BDL, Xu K, Smith AH, Crystal S, Gaither JR, Gordon AJ, Smith RV, Kember RL, Polimanti R, Gelernter J, Fiellin DA, Tate JP, Kranzler HR, Becker WC. Patterns and Correlates of Prescription Opioid Receipt Among US Veterans: A National, 18-Year Observational Cohort Study AIDS And Behavior 2019, 23: 3340-3349. PMID: 31317364, PMCID: PMC7344341, DOI: 10.1007/s10461-019-02608-3.
• Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X. Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes. Nicotine & Tobacco Research 2019, 22: 900-909. PMID: 31294817, PMCID: PMC7249921, DOI: 10.1093/ntr/ntz099.
• Inviting in the Exome for Alcohol and Smoking TraitsGelernter J. Inviting in the Exome for Alcohol and Smoking Traits Biological Psychiatry 2019, 85: 889-890. PMID: 31122339, PMCID: PMC7401834, DOI: 10.1016/j.biopsych.2019.04.005.
• Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependenceRosato AJ, Chen X, Tanaka Y, Farrer LA, Kranzler HR, Nunez YZ, Henderson DC, Gelernter J, Zhang H. Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence Epigenomics 2019, 11: 739-749. PMID: 31140863, PMCID: PMC6595542, DOI: 10.2217/epi-2018-0177.
• Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol‐Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism CohortMeda SA, Narayanan B, Chorlian D, Meyers JL, Gelernter J, Hesselbrock V, Bauer L, Calhoun VD, Porjesz B, Pearlson G. Multivariate Analyses Reveal Biological Components Related to Neuronal Signaling and Immunity Mediating Electroencephalograms Abnormalities in Alcohol‐Dependent Individuals from the Collaborative Study on the Genetics of Alcoholism Cohort Alcoholism Clinical And Experimental Research 2019, 43: 1462-1477. PMID: 31009096, DOI: 10.1111/acer.14063.
• Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populationsKranzler HR, Zhou H, Kember RL, Smith RV, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Author Correction: Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations Nature Communications 2019, 10: 2275. PMID: 31101824, PMCID: PMC6525240, DOI: 10.1038/s41467-019-10254-5.
• Genome‐wide analyses of psychological resilience in U.S. Army soldiersStein MB, Choi KW, Jain S, Campbell‐Sills L, Chen C, Gelernter J, He F, Heeringa SG, Maihofer AX, Nievergelt C, Nock MK, Ripke S, Sun X, Kessler RC, Smoller JW, Ursano RJ. Genome‐wide analyses of psychological resilience in U.S. Army soldiers American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 180: 310-319. PMID: 31081985, PMCID: PMC6551278, DOI: 10.1002/ajmg.b.32730.
• Association of Economic Status and Educational Attainment With Posttraumatic Stress DisorderPolimanti R, Ratanatharathorn A, Maihofer AX, Choi KW, Stein MB, Morey RA, Logue MW, Nievergelt CM, Stein DJ, Koenen KC, Gelernter J. Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder JAMA Network Open 2019, 2: e193447. PMID: 31050786, PMCID: PMC6503495, DOI: 10.1001/jamanetworkopen.2019.3447.
• Validation of an Electronic Medical Record–Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. VeteransHarrington KM, Quaden R, Stein MB, Honerlaw JP, Cissell S, Pietrzak RH, Zhao H, Radhakrishnan K, Aslan M, Gaziano JM, Concato J, Gagnon DR, Gelernter J, Cho K, Program O. Validation of an Electronic Medical Record–Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S. Veterans Journal Of Traumatic Stress 2019, 32: 226-237. PMID: 31009556, PMCID: PMC6699164, DOI: 10.1002/jts.22399.
• Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk LociGelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Program D, Program D, Program M, Program M. Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci Biological Psychiatry 2019, 86: 365-376. PMID: 31151762, PMCID: PMC6919570, DOI: 10.1016/j.biopsych.2019.03.984.
• Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populationsKranzler HR, Zhou H, Kember RL, Vickers Smith R, Justice AC, Damrauer S, Tsao PS, Klarin D, Baras A, Reid J, Overton J, Rader DJ, Cheng Z, Tate JP, Becker WC, Concato J, Xu K, Polimanti R, Zhao H, Gelernter J. Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations Nature Communications 2019, 10: 1499. PMID: 30940813, PMCID: PMC6445072, DOI: 10.1038/s41467-019-09480-8.
• Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortiumPolimanti R, Peterson RE, Ong JS, MacGregor S, Edwards AC, Clarke TK, Frank J, Gerring Z, Gillespie NA, Lind PA, Maes HH, Martin NG, Mbarek H, Medland SE, Streit F, Agrawal A, Edenberg H, Kendler K, Lewis C, Sullivan P, Wray N, Gelernter J, Derks E. Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium Psychological Medicine 2019, 49: 1218-1226. PMID: 30929657, PMCID: PMC6565601, DOI: 10.1017/s0033291719000667.
• Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American WomenMontalvo-Ortiz JL, Cheng Z, Kranzler HR, Zhang H, Gelernter J. Genomewide Study of Epigenetic Biomarkers of Opioid Dependence in European- American Women Scientific Reports 2019, 9: 4660. PMID: 30874594, PMCID: PMC6420601, DOI: 10.1038/s41598-019-41110-7.
• Alcohol-responsive genes identified in human iPSC-derived neural culturesJensen KP, Lieberman R, Kranzler HR, Gelernter J, Clinton K, Covault J. Alcohol-responsive genes identified in human iPSC-derived neural cultures Translational Psychiatry 2019, 9: 96. PMID: 30862775, PMCID: PMC6414668, DOI: 10.1038/s41398-019-0426-5.
• Genetics of AlcoholismEdenberg HJ, Gelernter J, Agrawal A. Genetics of Alcoholism Current Psychiatry Reports 2019, 21: 26. PMID: 30852706, DOI: 10.1007/s11920-019-1008-1.
• REGION-SPECIFIC ATROPHY AS MEASURED BY CORTICAL GRAY MATTER VOLUME IS ASSOCIATED WITH BOTH REGIONAL AND TOTAL CORTICAL AMYLOID-BETA BURDEN IN COGNITIVELY NORMAL INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASEO'Dell R, Gupta M, Gelernter J, Carson R, van Dyck C, Mecca A. REGION-SPECIFIC ATROPHY AS MEASURED BY CORTICAL GRAY MATTER VOLUME IS ASSOCIATED WITH BOTH REGIONAL AND TOTAL CORTICAL AMYLOID-BETA BURDEN IN COGNITIVELY NORMAL INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE American Journal Of Geriatric Psychiatry 2019, 27: s145-s146. DOI: 10.1016/j.jagp.2019.01.100.
• Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding VariantsPolimanti R, Nuñez YZ, Gelernter J. Increased Risk of Multiple Outpatient Surgeries in African-American Carriers of Transthyretin Val122Ile Mutation Is Modulated by Non-Coding Variants Journal Of Clinical Medicine 2019, 8: 269. PMID: 30813263, PMCID: PMC6406512, DOI: 10.3390/jcm8020269.
• Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575BRadhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Study #575B International Journal Of Methods In Psychiatric Research 2019, 28: e1767. PMID: 30767326, PMCID: PMC6877159, DOI: 10.1002/mpr.1767.
• Genetic associations with suicide attempt severity and genetic overlap with major depressionLevey DF, Polimanti R, Cheng Z, Zhou H, Nuñez YZ, Jain S, He F, Sun X, Ursano RJ, Kessler RC, Smoller JW, Stein MB, Kranzler HR, Gelernter J. Genetic associations with suicide attempt severity and genetic overlap with major depression Translational Psychiatry 2019, 9: 22. PMID: 30655502, PMCID: PMC6336846, DOI: 10.1038/s41398-018-0340-2.
• A Putative Causal Relationship Between Genetically Determined Female Body Shape And Post-Traumatic Stress DisorderPolimanti R, Amstadter A, Liberzon I, Nievergelt C, Workgroup P, Stein M, Koenen K, Gelernter J. A Putative Causal Relationship Between Genetically Determined Female Body Shape And Post-Traumatic Stress Disorder European Neuropsychopharmacology 2019, 29: s751-s752. DOI: 10.1016/j.euroneuro.2017.06.094.
• GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and networkXiang B, Yang B, Zhou H, Kranzler H, Gelernter J. GWAS and network analysis of co‐occurring nicotine and alcohol dependence identifies significantly associated alleles and network American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 180: 3-11. PMID: 30488612, PMCID: PMC6918694, DOI: 10.1002/ajmg.b.32692.
• Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disordersWalters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman J, Chen D, Choi D, Copeland W, Culverhouse R, Dahmen N, Degenhardt L, Domingue B, Elson S, Frye M, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey M, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray A, Nurnberger J, Palotie A, Preuss U, Räikkönen K, Reynolds M, Ridinger M, Scherbaum N, Schuckit M, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins D, Boden J, Boomsma D, Bierut L, Brown S, Bucholz K, Cichon S, Costello E, de Wit H, Diazgranados N, Dick D, Eriksson J, Farrer L, Foroud T, Gillespie N, Goate A, Goldman D, Grucza R, Hancock D, Harris K, Heath A, Hesselbrock V, Hewitt J, Hopfer C, Horwood J, Iacono W, Johnson E, Kaprio J, Karpyak V, Kendler K, Kranzler H, Krauter K, Lichtenstein P, Lind P, McGue M, MacKillop J, Madden P, Maes H, Magnusson P, Martin N, Medland S, Montgomery G, Nelson E, Nöthen M, Palmer A, Pedersen N, Penninx B, Porjesz B, Rice J, Rietschel M, Riley B, Rose R, Rujescu D, Shen P, Silberg J, Stallings M, Tarter R, Vanyukov M, Vrieze S, Wall T, Whitfield J, Zhao H, Neale B, Gelernter J, Edenberg H, Agrawal A. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders Nature Neuroscience 2018, 21: 1656-1669. PMID: 30482948, PMCID: PMC6430207, DOI: 10.1038/s41593-018-0275-1.
• Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorderDemontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, Gandal M, Goldstein JI, Grasby KL, Grove J, Gudmundsson OO, Hansen CS, Hauberg ME, Hollegaard MV, Howrigan DP, Huang H, Maller JB, Martin AR, Martin NG, Moran J, Pallesen J, Palmer DS, Pedersen CB, Pedersen MG, Poterba T, Poulsen JB, Ripke S, Robinson EB, Satterstrom FK, Stefansson H, Stevens C, Turley P, Walters GB, Won H, Wright MJ, Andreassen O, Asherson P, Burton C, Boomsma D, Cormand B, Dalsgaard S, Franke B, Gelernter J, Geschwind D, Hakonarson H, Haavik J, Kranzler H, Kuntsi J, Langley K, Lesch K, Middeldorp C, Reif A, Rohde L, Roussos P, Schachar R, Sklar P, Sonuga-Barke E, Sullivan P, Thapar A, Tung J, Waldman I, Medland S, Stefansson K, Nordentoft M, Hougaard D, Werge T, Mors O, Mortensen P, Daly M, Faraone S, Børglum A, Neale B. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder Nature Genetics 2018, 51: 63-75. PMID: 30478444, PMCID: PMC6481311, DOI: 10.1038/s41588-018-0269-7.
• Inferring phenotypes from substance use via collaborative matrix completionLu J, Sun J, Wang X, Kranzler H, Gelernter J, Bi J. Inferring phenotypes from substance use via collaborative matrix completion BMC Systems Biology 2018, 12: 104. PMID: 30463556, PMCID: PMC6249733, DOI: 10.1186/s12918-018-0623-5.
• Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2Smith AH, Ovesen PL, Skeldal S, Yeo S, Jensen KP, Olsen D, Diazgranados N, Zhao H, Farrer LA, Goldman D, Glerup S, Kranzler HR, Nykjær A, Gelernter J. Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2 Alcoholism Clinical And Experimental Research 2018, 42: 2337-2348. PMID: 30252935, PMCID: PMC6317871, DOI: 10.1111/acer.13890.
• Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls – CORRIGENDUMPettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, Børglum A, Bulik C, Daly M, Davis L, Demontis D, Edenberg H, Grove J, Gelernter J, Neale B, Pardiñas A, Stahl E, Walters J, Walters R, Sullivan P, Posthuma D, Polderman T. Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls – CORRIGENDUM Psychological Medicine 2018, 49: 351-351. PMID: 30334498, PMCID: PMC8054319, DOI: 10.1017/s0033291718002945.
• Using DNA methylation to validate an electronic medical record phenotype for smokingMcGinnis KA, Justice AC, Tate JP, Kranzler HR, Tindle HA, Becker WC, Concato J, Gelernter J, Li B, Zhang X, Zhao H, Crothers K, Xu K, Group F. Using DNA methylation to validate an electronic medical record phenotype for smoking Addiction Biology 2018, 24: 1056-1065. PMID: 30284751, PMCID: PMC6541538, DOI: 10.1111/adb.12670.
• Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depressionZhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.
• Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid DisordersRavera S, Carrasco N, Gelernter J, Polimanti R. Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders Journal Of Clinical Medicine 2018, 7: 296. PMID: 30248900, PMCID: PMC6210201, DOI: 10.3390/jcm7100296.
• Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controlsPettersson E, Lichtenstein P, Larsson H, Song J, Agrawal A, Børglum A, Bulik C, Daly M, Davis L, Demontis D, Edenberg H, Grove J, Gelernter J, Neale B, Pardiñas A, Stahl E, Walters J, Walters R, Sullivan P, Posthuma D, Polderman T. Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls Psychological Medicine 2018, 49: 1166-1173. PMID: 30221610, PMCID: PMC6421104, DOI: 10.1017/s0033291718002039.
• Adverse Childhood Experiences, Epigenetic Measures, and Obesity in YouthKaufman J, Montalvo-Ortiz JL, Holbrook H, O'Loughlin K, Orr C, Kearney C, Yang BZ, Wang T, Zhao H, Althoff R, Garavan H, Gelernter J, Hudziak J. Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth The Journal Of Pediatrics 2018, 202: 150-156.e3. PMID: 30177354, PMCID: PMC6513669, DOI: 10.1016/j.jpeds.2018.06.051.
• GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liabilityPasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, the 23andMe Research Team, de Wit H, Davis LK, MacKillop J, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability Nature Neuroscience 2018, 21: 1161-1170. PMID: 30150663, PMCID: PMC6386176, DOI: 10.1038/s41593-018-0206-1.
• Genome‐wide association meta‐analysis of age at first cannabis useMinică CC, Verweij KJH, Most P, Mbarek H, Bernard M, Eijk K, Lind PA, Liu MZ, Maciejewski DF, Palviainen T, Sánchez‐Mora C, Sherva R, Taylor M, Walters RK, Abdellaoui A, Bigdeli TB, Branje SJT, Brown SA, Casas M, Corley RP, Davey‐Smith G, Davies GE, Ehli EA, Farrer L, Fedko IO, Garcia‐Martínez I, Gordon SD, Hartman CA, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Kahn RS, Kaprio J, Korhonen T, Kranzler HR, Krauter K, Lier P, Madden PAF, Medland SE, Neale MC, Meeus WHJ, Montgomery GW, Nolte IM, Oldehinkel AJ, Pausova Z, Ramos‐Quiroga J, Richarte V, Rose RJ, Shin J, Stallings MC, Wall TL, Ware JJ, Wright MJ, Zhao H, Koot HM, Paus T, Hewitt JK, Ribasés M, Loukola A, Boks MP, Snieder H, Munafò MR, Gelernter J, Boomsma DI, Martin NG, Gillespie NA, Vink JM, Derks EM. Genome‐wide association meta‐analysis of age at first cannabis use Addiction 2018, 113: 2073-2086. PMID: 30003630, PMCID: PMC7087375, DOI: 10.1111/add.14368.
• Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokersJensen KP, Valentine G, Buta E, DeVito EE, Gelernter J, Sofuoglu M. Biochemical, demographic, and self-reported tobacco-related predictors of the acute heart rate response to nicotine in smokers Pharmacology Biochemistry And Behavior 2018, 173: 36-43. PMID: 30107183, PMCID: PMC6125200, DOI: 10.1016/j.pbb.2018.08.004.
• AUDIT‐C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populationsJustice AC, Smith RV, Tate JP, McGinnis K, Xu K, Becker WC, Lee K, Lynch K, Sun N, Concato J, Fiellin DA, Zhao H, Gelernter J, Kranzler HR, Program O. AUDIT‐C and ICD codes as phenotypes for harmful alcohol use: association with ADH1B polymorphisms in two US populations Addiction 2018, 113: 2214-2224. PMID: 29972609, PMCID: PMC6226338, DOI: 10.1111/add.14374.
• Genome‐wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting TestZhang H, Zhou H, Lencz T, Farrer LA, Kranzler HR, Gelernter J. Genome‐wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 177: 511-519. PMID: 30134085, PMCID: PMC6110090, DOI: 10.1002/ajmg.b.32642.
• Methylation in OTX2 and related genes, maltreatment, and depression in childrenKaufman J, Wymbs NF, Montalvo-Ortiz JL, Orr C, Albaugh MD, Althoff R, O’Loughlin K, Holbrook H, Garavan H, Kearney C, Yang BZ, Zhao H, Peña C, Nestler EJ, Lee RS, Mostofsky S, Gelernter J, Hudziak J. Methylation in OTX2 and related genes, maltreatment, and depression in children Neuropsychopharmacology 2018, 43: 2204-2211. PMID: 30089883, PMCID: PMC6135753, DOI: 10.1038/s41386-018-0157-y.
• Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis responseMontalvo-Ortiz JL, Zhou H, D’Andrea I, Maroteaux L, Lori A, Smith A, Ressler KJ, Nuñez YZ, Farrer LA, Zhao H, Kranzler HR, Gelernter J. Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response Molecular Psychiatry 2018, 23: 2277-2286. PMID: 29875475, PMCID: PMC6281782, DOI: 10.1038/s41380-018-0077-6.
• Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traitsPolimanti R, Kayser MH, Gelernter J. Local adaptation in European populations affected the genetics of psychiatric disorders and behavioral traits Genome Medicine 2018, 10: 24. PMID: 29580271, PMCID: PMC5870256, DOI: 10.1186/s13073-018-0532-7.
• Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai PopulationGelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population Alcoholism Clinical And Experimental Research 2018, 42: 861-868. PMID: 29460428, PMCID: PMC5916336, DOI: 10.1111/acer.13614.
• Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia.Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Multivariate Pattern Analysis of Genotype-Phenotype Relationships in Schizophrenia. Schizophrenia Bulletin 2018, 44: 1045-1052. PMID: 29534239, PMCID: PMC6101611, DOI: 10.1093/schbul/sby005.
• Genome-wide analysis of insomnia disorderStein MB, McCarthy MJ, Chen CY, Jain S, Gelernter J, He F, Heeringa SG, Kessler RC, Nock MK, Ripke S, Sun X, Wynn GH, Smoller JW, Ursano RJ. Genome-wide analysis of insomnia disorder Molecular Psychiatry 2018, 23: 2238-2250. PMID: 29520036, PMCID: PMC6129221, DOI: 10.1038/s41380-018-0033-5.
• Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.Duncan LE, Ratanatharathorn A, Aiello AE, Almli LM, Amstadter AB, Ashley-Koch AE, Baker DG, Beckham JC, Bierut LJ, Bisson J, Bradley B, Chen CY, Dalvie S, Farrer LA, Galea S, Garrett ME, Gelernter JE, Guffanti G, Hauser MA, Johnson EO, Kessler RC, Kimbrel NA, King A, Koen N, Kranzler HR, Logue MW, Maihofer AX, Martin AR, Miller MW, Morey RA, Nugent NR, Rice JP, Ripke S, Roberts AL, Saccone NL, Smoller JW, Stein DJ, Stein MB, Sumner JA, Uddin M, Ursano RJ, Wildman DE, Yehuda R, Zhao H, Daly MJ, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry 2018, 23: 666-673. PMID: 28439101, PMCID: PMC5696105, DOI: 10.1038/mp.2017.77.
• Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European AmericansCheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans Biological Psychiatry 2018, 84: 762-770. PMID: 29478698, PMCID: PMC6041180, DOI: 10.1016/j.biopsych.2017.12.016.
• Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiersPolimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J, Heeringa S, Wagner J, Cox K, Aliaga P, Benedek C, Campbell‐Sills L, Fullerton C, Gebler N, Gifford R, Hurwitz P, Jain S, Lewandowski‐Romps L, Herberman Mash H, McCarroll J, Naifeh J, Hinz Ng T, Nock M, Santiago P, Wynn G, Zaslavsky A. Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers Acta Psychiatrica Scandinavica 2017, 137: 148-156. PMID: 29230810, PMCID: PMC6110087, DOI: 10.1111/acps.12843.
• Genome-Wide Association Studies of a Broad Spectrum of Antisocial BehaviorTielbeek JJ, Johansson A, Polderman TJC, Rautiainen MR, Jansen P, Taylor M, Tong X, Lu Q, Burt AS, Tiemeier H, Viding E, Plomin R, Martin NG, Heath AC, Madden PAF, Montgomery G, Beaver KM, Waldman I, Gelernter J, Kranzler HR, Farrer LA, Perry JRB, Munafò M, LoParo D, Paunio T, Tiihonen J, Mous SE, Pappa I, de Leeuw C, Watanabe K, Hammerschlag AR, Salvatore JE, Aliev F, Bigdeli TB, Dick D, Faraone SV, Popma A, Medland SE, Posthuma D. Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior JAMA Psychiatry 2017, 74: 1242-1250. PMID: 28979981, PMCID: PMC6309228, DOI: 10.1001/jamapsychiatry.2017.3069.
• Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major DepressionZhou H, Polimanti R, Yang BZ, Wang Q, Han S, Sherva R, Nuñez YZ, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression JAMA Psychiatry 2017, 74: 1234-1241. PMID: 29071344, PMCID: PMC6331050, DOI: 10.1001/jamapsychiatry.2017.3275.
• A putative causal relationship between genetically determined female body shape and posttraumatic stress disorderPolimanti R, Amstadter AB, Stein MB, Almli LM, Baker DG, Bierut LJ, Bradley B, Farrer LA, Johnson EO, King A, Kranzler HR, Maihofer AX, Rice JP, Roberts AL, Saccone NL, Zhao H, Liberzon I, Ressler KJ, Nievergelt CM, Koenen KC, Gelernter J, for The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup. A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder Genome Medicine 2017, 9: 99. PMID: 29178946, PMCID: PMC5702961, DOI: 10.1186/s13073-017-0491-4.
• Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans StudyMota NP, Han S, Harpaz‐Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study Depression And Anxiety 2017, 35: 168-177. PMID: 29172227, PMCID: PMC5794529, DOI: 10.1002/da.22698.
• GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social DrinkersYang B, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers Alcoholism Clinical And Experimental Research 2017, 41: 2025-2032. PMID: 29131352, PMCID: PMC5764175, DOI: 10.1111/acer.13516.
• Genome-wide association study identifies a novel locus for cannabis dependenceAgrawal A, Chou YL, Carey CE, Baranger DAA, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang JC, Bertelsen S, Anokhin AP, Hesselbrock V, Kramer J, Lynskey MT, Meyers JL, Nurnberger JI, Rice JP, Tischfield J, Bierut LJ, Degenhardt L, Farrer LA, Gelernter J, Hariri AR, Heath AC, Kranzler HR, Madden PAF, Martin NG, Montgomery GW, Porjesz B, Wang T, Whitfield JB, Edenberg HJ, Foroud T, Goate AM, Bogdan R, Nelson EC. Genome-wide association study identifies a novel locus for cannabis dependence Molecular Psychiatry 2017, 23: 1293-1302. PMID: 29112194, PMCID: PMC5938138, DOI: 10.1038/mp.2017.200.
• Polygenic Scores for Major Depressive Disorder and Risk of Alcohol DependenceAndersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.
• Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes.Lu J, Sun J, Wang X, Kranzler HR, Gelernter J, Bi J. Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes. Proceedings. IEEE International Conference On Bioinformatics And Biomedicine 2017, 2017: 392-397. PMID: 29755832, PMCID: PMC5947969, DOI: 10.1109/BIBM.2017.8217681.
• Genetically determined schizophrenia is not associated with impaired glucose homeostasisPolimanti R, Gelernter J, Stein DJ. Genetically determined schizophrenia is not associated with impaired glucose homeostasis Schizophrenia Research 2017, 195: 286-289. PMID: 29092750, PMCID: PMC5924728, DOI: 10.1016/j.schres.2017.10.033.
• Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal Of Clinical Psychiatry 2017, 78: e1058-e1059. PMID: 29099554, DOI: 10.4088/jcp.17l11646.
• Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviorsPolimanti R, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Ancestry‐specific and sex‐specific risk alleles identified in a genome‐wide gene‐by‐alcohol dependence interaction study of risky sexual behaviors American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 846-853. PMID: 28990359, PMCID: PMC5861711, DOI: 10.1002/ajmg.b.32604.
• Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's diseaseMecca AP, Barcelos NM, Wang S, Brück A, Nabulsi N, Planeta-Wilson B, Nadelmann J, Benincasa AL, Ropchan J, Huang Y, Gelernter J, Van Ness PH, Carson RE, van Dyck CH. Cortical β-amyloid burden, gray matter, and memory in adults at varying APOE ε4 risk for Alzheimer's disease Neurobiology Of Aging 2017, 61: 207-214. PMID: 29111487, PMCID: PMC5722236, DOI: 10.1016/j.neurobiolaging.2017.09.027.
• Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependenceHancock DB, Guo Y, Reginsson GW, Gaddis NC, Lutz SM, Sherva R, Loukola A, Minica CC, Markunas CA, Han Y, Young KA, Gudbjartsson DF, Gu F, McNeil DW, Qaiser B, Glasheen C, Olson S, Landi MT, Madden PAF, Farrer LA, Vink J, Saccone NL, Neale MC, Kranzler HR, McKay J, Hung RJ, Amos CI, Marazita ML, Boomsma DI, Baker TB, Gelernter J, Kaprio J, Caporaso NE, Thorgeirsson TE, Hokanson JE, Bierut LJ, Stefansson K, Johnson EO. Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence Molecular Psychiatry 2017, 23: 1911-1919. PMID: 28972577, PMCID: PMC5882602, DOI: 10.1038/mp.2017.193.
• Psychiatric Genomics: An Update and an AgendaSullivan PF, Agrawal A, Bulik CM, Andreassen OA, Børglum AD, Breen G, Cichon S, Edenberg HJ, Faraone SV, Gelernter J, Mathews CA, Nievergelt CM, Smoller JW, O'Donovan MC. Psychiatric Genomics: An Update and an Agenda American Journal Of Psychiatry 2017, 175: 15-27. PMID: 28969442, PMCID: PMC5756100, DOI: 10.1176/appi.ajp.2017.17030283.
• Genomewide association studies of suicide attempts in US soldiersStein MB, Ware EB, Mitchell C, Chen C, Borja S, Cai T, Dempsey CL, Fullerton CS, Gelernter J, Heeringa SG, Jain S, Kessler RC, Naifeh JA, Nock MK, Ripke S, Sun X, Beckham JC, Kimbrel NA, VA Mid‐Atlantic Mental Illness Research E, Ursano RJ, Smoller JW. Genomewide association studies of suicide attempts in US soldiers American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 786-797. PMID: 28902444, PMCID: PMC5685938, DOI: 10.1002/ajmg.b.32594.
• Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorderLippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Genetic variation of ANK3 is associated with lower white matter structural integrity in bipolar disorder Molecular Psychiatry 2017, 22: 1225-1225. PMID: 28831200, DOI: 10.1038/mp.2017.169.
• Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans StudySippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study Journal Of Psychiatric Research 2017, 94: 139-147. PMID: 28715704, PMCID: PMC5605420, DOI: 10.1016/j.jpsychires.2017.07.008.
• S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behavioursPolimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours Journal Of Psychiatry And Neuroscience 2017, 42: 252-261. PMID: 28418321, PMCID: PMC5487272, DOI: 10.1503/jpn.160189.
• Genetic–epigenetic interactions in cis: a major focus in the post-GWAS eraDo C, Shearer A, Suzuki M, Terry MB, Gelernter J, Greally JM, Tycko B. Genetic–epigenetic interactions in cis: a major focus in the post-GWAS era Genome Biology 2017, 18: 120. PMID: 28629478, PMCID: PMC5477265, DOI: 10.1186/s13059-017-1250-y.
• Genetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescentsBountress K, Danielson CK, Williamson V, Vladmirov V, Gelernter J, Ruggiero K, Amstadter A. Genetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescents American Journal On Addictions 2017, 26: 623-631. PMID: 28594439, PMCID: PMC5627968, DOI: 10.1111/ajad.12575.
• Genetic risk variants for social anxietyStein MB, Chen C, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J, Collaborators O. Genetic risk variants for social anxiety American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 470-482. PMID: 28512750, DOI: 10.1002/ajmg.b.32541.
• Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokersPolimanti R, Jensen KP, Gelernter J. Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers Scientific Reports 2017, 7: 1034. PMID: 28432340, PMCID: PMC5430682, DOI: 10.1038/s41598-017-01098-4.
• Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1BJustice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B Alcoholism Clinical And Experimental Research 2017, 41: 998-1003. PMID: 28295416, PMCID: PMC5501250, DOI: 10.1111/acer.13373.
• Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model OrganismsAdkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D, Consortium C, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, Consortium T, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms Alcoholism Clinical And Experimental Research 2017, 41: 911-928. PMID: 28226201, PMCID: PMC5404949, DOI: 10.1111/acer.13362.
• ADH1B: From alcoholism, natural selection, and cancer to the human phenomePolimanti R, Gelernter J. ADH1B: From alcoholism, natural selection, and cancer to the human phenome American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 177: 113-125. PMID: 28349588, PMCID: PMC5617762, DOI: 10.1002/ajmg.b.32523.
• Schizophrenia and substance use comorbidity: a genome-wide perspectivePolimanti R, Agrawal A, Gelernter J. Schizophrenia and substance use comorbidity: a genome-wide perspective Genome Medicine 2017, 9: 25. PMID: 28327175, PMCID: PMC5359801, DOI: 10.1186/s13073-017-0423-3.
• A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locusPolimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus Molecular Psychiatry 2017, 23: 154-160. PMID: 28265120, PMCID: PMC5589475, DOI: 10.1038/mp.2017.24.
• Genetic risk variants for social anxietyStein MB, Chen C, Jain S, Jensen KP, He F, Heeringa SG, Kessler RC, Maihofer A, Nock MK, Ripke S, Sun X, Thomas ML, Ursano RJ, Smoller JW, Gelernter J, Collaborators O. Genetic risk variants for social anxiety American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2017, 174: 120-131. PMID: 28224735, PMCID: PMC5325045, DOI: 10.1002/ajmg.b.32520.
• Predictors of tanning dependence in white non‐Hispanic females and malesCartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non‐Hispanic females and males Journal Of The European Academy Of Dermatology And Venereology 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.
• Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorderPolimanti R, Gelernter J. Widespread signatures of positive selection in common risk alleles associated to autism spectrum disorder PLOS Genetics 2017, 13: e1006618. PMID: 28187187, PMCID: PMC5328401, DOI: 10.1371/journal.pgen.1006618.
• Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genesXu H, Wang F, Kranzler HR, Gelernter J, Zhang H. Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes Scientific Reports 2017, 7: 41816. PMID: 28165486, PMCID: PMC5292964, DOI: 10.1038/srep41816.
• Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1 Molecular Psychiatry 2017, 22: 346-352. PMID: 28115739, PMCID: PMC5407902, DOI: 10.1038/mp.2016.257.
• Systems Genetics of Autism Spectrum Disorders And Schizophrenia Are Enriched For Natural-Selection SignaturesPolimanti R, Gelernter J. Systems Genetics of Autism Spectrum Disorders And Schizophrenia Are Enriched For Natural-Selection Signatures European Neuropsychopharmacology 2017, 27: s419. DOI: 10.1016/j.euroneuro.2016.09.468.
• Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment CenterRungnirundorn T, Verachai V, Gelernter J, Malison RT, Kalayasiri R. Sex Differences in Methamphetamine Use and Dependence in a Thai Treatment Center Journal Of Addiction Medicine 2017, 11: 19. PMID: 27649265, PMCID: PMC5291761, DOI: 10.1097/adm.0000000000000262.
• Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. ArmyStein MB, Campbell‐Sills L, Gelernter J, He F, Heeringa SG, Nock MK, Sampson NA, Sun X, Jain S, Kessler RC, Ursano RJ, Collaborators S. Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. Army Alcoholism Clinical And Experimental Research 2016, 41: 139-148. PMID: 27883222, PMCID: PMC5205544, DOI: 10.1111/acer.13269.
• Sex‐specific linkage scans in opioid dependenceYang B, Han S, Kranzler HR, Palmer AA, Gelernter J. Sex‐specific linkage scans in opioid dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2016, 174: 261-268. PMID: 27762075, PMCID: PMC5695218, DOI: 10.1002/ajmg.b.32507.
• Review: DNA methylation and alcohol use disorders: Progress and challengesZhang H, Gelernter J. Review: DNA methylation and alcohol use disorders: Progress and challenges American Journal On Addictions 2016, 26: 502-515. PMID: 27759945, PMCID: PMC6003819, DOI: 10.1111/ajad.12465.
• Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functionsWang Q, Polimanti R, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions Human Genetics 2016, 136: 75-83. PMID: 27752767, PMCID: PMC5215962, DOI: 10.1007/s00439-016-1737-8.
• Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics.Agrawal A, Edenberg HJ, Gelernter J. Meta-Analyses of Genome-Wide Association Data Hold New Promise for Addiction Genetics. Journal Of Studies On Alcohol And Drugs 2016, 77: 676-80. PMID: 27588522, PMCID: PMC5015465, DOI: 10.15288/jsad.2016.77.676.
• Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain InjuryPolimanti R, Chen CY, Ursano RJ, Heeringa SG, Jain S, Kessler RC, Nock MK, Smoller JW, Sun X, Gelernter J, Stein MB. Cross-Phenotype Polygenic Risk Score Analysis of Persistent Post-Concussive Symptoms in U.S. Army Soldiers with Deployment-Acquired Traumatic Brain Injury Journal Of Neurotrauma 2016, 34: 781-789. PMID: 27439997, PMCID: PMC5314978, DOI: 10.1089/neu.2016.4550.
• Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric TraitsPolimanti R, Yang BZ, Zhao H, Gelernter J. Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits PLOS ONE 2016, 11: e0160654. PMID: 27537407, PMCID: PMC4990182, DOI: 10.1371/journal.pone.0160654.
• The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk GenePolimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene Neuropsychopharmacology 2016, 42: 598-605. PMID: 27531626, PMCID: PMC5240175, DOI: 10.1038/npp.2016.153.
• The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglectMontalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.
• Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity DisorderKhadka S, Pearlson GD, Calhoun VD, Liu J, Gelernter J, Bessette KL, Stevens MC. Multivariate Imaging Genetics Study of MRI Gray Matter Volume and SNPs Reveals Biological Pathways Correlated with Brain Structural Differences in Attention Deficit Hyperactivity Disorder Frontiers In Psychiatry 2016, 7: 128. PMID: 27504100, PMCID: PMC4959119, DOI: 10.3389/fpsyt.2016.00128.
• Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army SoldiersStein MB, Chen CY, Ursano RJ, Cai T, Gelernter J, Heeringa SG, Jain S, Jensen KP, Maihofer AX, Mitchell C, Nievergelt CM, Nock MK, Neale BM, Polimanti R, Ripke S, Sun X, Thomas ML, Wang Q, Ware EB, Borja S, Kessler RC, Smoller JW. Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers JAMA Psychiatry 2016, 73: 695-704. PMID: 27167565, PMCID: PMC4936936, DOI: 10.1001/jamapsychiatry.2016.0350.
• Effects of ANK3 variation on gray and white matter in bipolar disorderLippard ETC, Jensen KP, Wang F, Johnston JAY, Spencer L, Pittman B, Gelernter J, Blumberg HP. Effects of ANK3 variation on gray and white matter in bipolar disorder Molecular Psychiatry 2016, 22: 1345-1351. PMID: 27240527, PMCID: PMC5133179, DOI: 10.1038/mp.2016.76.
• Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 WomenPolimanti R, Kranzler HR, Gelernter J. Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women Neuropsychopharmacology 2016, 41: 2688-2696. PMID: 27187070, PMCID: PMC5026736, DOI: 10.1038/npp.2016.72.
• Genetic Relationship between Schizophrenia and Nicotine DependenceChen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, Ware JJ, Vink JM, Kaprio J, Munafò M, Chen X. Genetic Relationship between Schizophrenia and Nicotine Dependence Scientific Reports 2016, 6: 25671. PMID: 27164557, PMCID: PMC4862382, DOI: 10.1038/srep25671.
• Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic RisksSherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks JAMA Psychiatry 2016, 73: 472. PMID: 27028160, PMCID: PMC4974817, DOI: 10.1001/jamapsychiatry.2016.0036.
• A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smokeJensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke Molecular Psychiatry 2016, 22: 242-249. PMID: 27067016, PMCID: PMC5390815, DOI: 10.1038/mp.2016.43.
• CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation. Nicotine & Tobacco Research 2016, 18: 1845-52. PMID: 27611310, PMCID: PMC4978979, DOI: 10.1093/ntr/ntw081.
• Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis ConsortiumStringer S, Minică CC, Verweij KJ, Mbarek H, Bernard M, Derringer J, van Eijk KR, Isen JD, Loukola A, Maciejewski DF, Mihailov E, van der Most PJ, Sánchez-Mora C, Roos L, Sherva R, Walters R, Ware JJ, Abdellaoui A, Bigdeli TB, Branje SJ, Brown SA, Bruinenberg M, Casas M, Esko T, Garcia-Martinez I, Gordon SD, Harris JM, Hartman CA, Henders AK, Heath AC, Hickie IB, Hickman M, Hopfer CJ, Hottenga JJ, Huizink AC, Irons DE, Kahn RS, Korhonen T, Kranzler HR, Krauter K, van Lier PA, Lubke GH, Madden PA, Mägi R, McGue MK, Medland SE, Meeus WH, Miller MB, Montgomery GW, Nivard MG, Nolte IM, Oldehinkel AJ, Pausova Z, Qaiser B, Quaye L, Ramos-Quiroga JA, Richarte V, Rose RJ, Shin J, Stallings MC, Stiby AI, Wall TL, Wright MJ, Koot HM, Paus T, Hewitt JK, Ribasés M, Kaprio J, Boks MP, Snieder H, Spector T, Munafò MR, Metspalu A, Gelernter J, Boomsma DI, Iacono WG, Martin NG, Gillespie NA, Derks EM, Vink JM. Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium Translational Psychiatry 2016, 6: e769-e769. PMID: 27023175, PMCID: PMC4872459, DOI: 10.1038/tp.2016.36.
• CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving.Shmulewitz D, Meyers JL, Wall MM, Aharonovich E, Frisch A, Spivak B, Weizman A, Edenberg HJ, Gelernter J, Hasin DS. CHRNA5/A3/B4 Variant rs3743078 and Nicotine-Related Phenotypes: Indirect Effects Through Nicotine Craving. Journal Of Studies On Alcohol And Drugs 2016, 77: 227-37. PMID: 26997181, PMCID: PMC4803655, DOI: 10.15288/jsad.2016.77.227.
• DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disordersWang F, Xu H, Zhao H, Gelernter J, Zhang H. DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders Scientific Reports 2016, 6: 19430. PMID: 26763658, PMCID: PMC4725922, DOI: 10.1038/srep19430.
• RDoC and translational perspectives on the genetics of trauma‐related psychiatric disordersMontalvo-Ortiz JL, Gelernter J, Hudziak J, Kaufman J. RDoC and translational perspectives on the genetics of trauma‐related psychiatric disorders American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 171: 81-91. PMID: 26592203, PMCID: PMC4754782, DOI: 10.1002/ajmg.b.32395.
• Genome‐wide association study of body mass index in subjects with alcohol dependencePolimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Genome‐wide association study of body mass index in subjects with alcohol dependence Addiction Biology 2015, 22: 535-549. PMID: 26458734, PMCID: PMC5102811, DOI: 10.1111/adb.12317.
• Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependenceHancock DB, Reginsson GW, Gaddis NC, Chen X, Saccone NL, Lutz SM, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey SN, Glasheen C, Chen J, Gu F, Frederiksen BN, Loukola A, Gudbjartsson DF, Brüske I, Landi MT, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler HR, Gelernter J, Baker TB, Kraft P, Amos CI, Caporaso NE, Hokanson JE, Bierut LJ, Thorgeirsson TE, Johnson EO, Stefansson K. Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence Translational Psychiatry 2015, 5: e651-e651. PMID: 26440539, PMCID: PMC4930126, DOI: 10.1038/tp.2015.149.
• Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry CohortsSchwantes-An TH, Zhang J, Chen LS, Hartz SM, Culverhouse RC, Chen X, Coon H, Frank J, Kamens HM, Konte B, Kovanen L, Latvala A, Legrand LN, Maher BS, Melroy WE, Nelson EC, Reid MW, Robinson JD, Shen PH, Yang BZ, Andrews JA, Aveyard P, Beltcheva O, Brown SA, Cannon DS, Cichon S, Corley RP, Dahmen N, Degenhardt L, Foroud T, Gaebel W, Giegling I, Glatt SJ, Grucza RA, Hardin J, Hartmann AM, Heath AC, Herms S, Hodgkinson CA, Hoffmann P, Hops H, Huizinga D, Ising M, Johnson EO, Johnstone E, Kaneva RP, Kendler KS, Kiefer F, Kranzler HR, Krauter KS, Levran O, Lucae S, Lynskey MT, Maier W, Mann K, Martin NG, Mattheisen M, Montgomery GW, Müller-Myhsok B, Murphy MF, Neale MC, Nikolov MA, Nishita D, Nöthen MM, Nurnberger J, Partonen T, Pergadia ML, Reynolds M, Ridinger M, Rose RJ, Rouvinen-Lagerström N, Scherbaum N, Schmäl C, Soyka M, Stallings MC, Steffens M, Treutlein J, Tsuang M, Wall TL, Wodarz N, Yuferov V, Zill P, Bergen AW, Chen J, Cinciripini PM, Edenberg HJ, Ehringer MA, Ferrell RE, Gelernter J, Goldman D, Hewitt JK, Hopfer CJ, Iacono WG, Kaprio J, Kreek MJ, Kremensky IM, Madden PA, McGue M, Munafò MR, Philibert RA, Rietschel M, Roy A, Rujescu D, Saarikoski ST, Swan GE, Todorov AA, Vanyukov MM, Weiss RB, Bierut LJ, Saccone NL. Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts Behavior Genetics 2015, 46: 151-169. PMID: 26392368, PMCID: PMC4752855, DOI: 10.1007/s10519-015-9737-3.
• The genetics of alcohol dependence: Twin and SNP‐based heritability, and genome‐wide association study based on AUDIT scoresMbarek H, Milaneschi Y, Fedko IO, Hottenga JJ, de Moor MH, Jansen R, Gelernter J, Sherva R, Willemsen G, Boomsma DI, Penninx BW, Vink JM. The genetics of alcohol dependence: Twin and SNP‐based heritability, and genome‐wide association study based on AUDIT scores American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 739-748. PMID: 26365420, DOI: 10.1002/ajmg.b.32379.
• Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWASWang Q, Yang C, Gelernter J, Zhao H. Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS Human Genetics 2015, 134: 1195-1209. PMID: 26340901, PMCID: PMC4630076, DOI: 10.1007/s00439-015-1596-8.
• Further analyses support the association between light eye color and alcohol dependenceSulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Further analyses support the association between light eye color and alcohol dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 757-760. PMID: 26290254, DOI: 10.1002/ajmg.b.32357.
• Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical NeuronsXiang Y, Kim KY, Gelernter J, Park IH, Zhang H. Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons PLOS ONE 2015, 10: e0134907. PMID: 26266540, PMCID: PMC4534442, DOI: 10.1371/journal.pone.0134907.
• Dissecting ancestry genomic background in substance dependence genome-wide association studiesPolimanti R, Yang C, Zhao H, Gelernter J. Dissecting ancestry genomic background in substance dependence genome-wide association studies Pharmacogenomics 2015, 16: 1487-1498. PMID: 26267224, PMCID: PMC4632979, DOI: 10.2217/pgs.15.91.
• Evidence of CNIH3 involvement in opioid dependenceNelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, Gordon S, Henders AK, Hesselbrock V, Kapoor M, Lynskey MT, Madden PA, Moron JA, Rice JP, Saccone NL, Schwab SG, Shand FL, Todorov AA, Wallace L, Wang T, Wray NR, Zhou X, Degenhardt L, Martin NG, Hariri AR, Kranzler HR, Gelernter J, Bierut LJ, Clark DJ, Montgomery GW. Evidence of CNIH3 involvement in opioid dependence Molecular Psychiatry 2015, 21: 608-614. PMID: 26239289, PMCID: PMC4740268, DOI: 10.1038/mp.2015.102.
• The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated ChildrenKaufman J, Gelernter J, Hudziak JJ, Tyrka AR, Coplan JD. The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 617-625. PMID: 26210330, PMCID: PMC4515569, DOI: 10.1016/j.jaac.2015.06.001.
• Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African AmericansXu K, Kranzler HR, Sherva R, Sartor CE, Almasy L, Koesterer R, Zhao H, Farrer LA, Gelernter J. Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans Alcoholism Clinical And Experimental Research 2015, 39: 1137-1147. PMID: 26036284, PMCID: PMC4706077, DOI: 10.1111/acer.12751.
• Inter-observer reliability of DSM-5 substance use disordersDenis CM, Gelernter J, Hart AB, Kranzler HR. Inter-observer reliability of DSM-5 substance use disorders Drug And Alcohol Dependence 2015, 153: 229-235. PMID: 26048641, PMCID: PMC4509850, DOI: 10.1016/j.drugalcdep.2015.05.019.
• A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in HumansJensen KP, DeVito EE, Herman AI, Valentine GW, Gelernter J, Sofuoglu M. A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans Neuropsychopharmacology 2015, 40: 2813-2821. PMID: 25948103, PMCID: PMC4864657, DOI: 10.1038/npp.2015.131.
• Eye color: A potential indicator of alcohol dependence risk in European AmericansSulovari A, Kranzler HR, Farrer LA, Gelernter J, Li D. Eye color: A potential indicator of alcohol dependence risk in European Americans American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 347-353. PMID: 25921801, DOI: 10.1002/ajmg.b.32316.
• Alcohol dependence cognitionClarke T, Smith AH, Gelernter J, Kranzler HR, Farrer LA, Hall LS, Fernandez‐Pujals A, MacIntyre DJ, Smith BH, Hocking LJ, Padmanabhan S, Hayward C, Thomson PA, Porteous DJ, Deary IJ, McIntosh AM. Alcohol dependence cognition Addiction Biology 2015, 21: 469-480. PMID: 25865819, PMCID: PMC4600406, DOI: 10.1111/adb.12245.
• ADH1B variants and AUDHart AB, Lynch KG, Farrer L, Gelernter J, Kranzler HR. ADH1B variants and AUD Addiction Biology 2015, 21: 924-938. PMID: 25828809, PMCID: PMC4591076, DOI: 10.1111/adb.12244.
• Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasetsVongpaisarnsin K, Listman JB, Malison RT, Gelernter J. Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets Legal Medicine 2015, 17: 245-250. PMID: 25759192, PMCID: PMC4480199, DOI: 10.1016/j.legalmed.2015.02.004.
• FKBP5 variation is associated with the acute and chronic effects of nicotineJensen KP, Herman AI, Morean ME, Kranzler HR, Gelernter J, Sofuoglu M. FKBP5 variation is associated with the acute and chronic effects of nicotine The Pharmacogenomics Journal 2014, 15: 340-346. PMID: 25532758, PMCID: PMC4599366, DOI: 10.1038/tpj.2014.76.
• Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing lossHaraksingh RR, Jahanbani F, Rodriguez-Paris J, Gelernter J, Nadeau KC, Oghalai JS, Schrijver I, Snyder MP. Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss BMC Genomics 2014, 15: 1155. PMID: 25528277, PMCID: PMC4367882, DOI: 10.1186/1471-2164-15-1155.
• Posttreatment Effects of Topiramate Treatment for Heavy DrinkingKranzler HR, Wetherill R, Feinn R, Pond T, Gelernter J, Covault J. Posttreatment Effects of Topiramate Treatment for Heavy Drinking Alcoholism Clinical And Experimental Research 2014, 38: 3017-3023. PMID: 25581656, PMCID: PMC4293099, DOI: 10.1111/acer.12578.
• The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African‐American and European‐American Women and MenSartor CE, Wang Z, Xu K, Kranzler HR, Gelernter J. The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African‐American and European‐American Women and Men Alcoholism Clinical And Experimental Research 2014, 38: 2907-2914. PMID: 25410943, PMCID: PMC4445128, DOI: 10.1111/acer.12572.
• GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and AnnotationChung D, Yang C, Li C, Gelernter J, Zhao H. GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation PLOS Genetics 2014, 10: e1004787. PMID: 25393678, PMCID: PMC4230845, DOI: 10.1371/journal.pgen.1004787.
• Genetic association of impulsivity in young adults: a multivariate studyKhadka S, Narayanan B, Meda SA, Gelernter J, Han S, Sawyer B, Aslanzadeh F, Stevens MC, Hawkins KA, Anticevic A, Potenza MN, Pearlson GD. Genetic association of impulsivity in young adults: a multivariate study Translational Psychiatry 2014, 4: e451-e451. PMID: 25268255, PMCID: PMC4199418, DOI: 10.1038/tp.2014.95.
• Genome-Wide Association Study of Copy Number Variations (CNVs) with Opioid DependenceLi D, Zhao H, Kranzler HR, Li MD, Jensen KP, Zayats T, Farrer LA, Gelernter J. Genome-Wide Association Study of Copy Number Variations (CNVs) with Opioid Dependence Neuropsychopharmacology 2014, 40: 1016-1026. PMID: 25345593, PMCID: PMC4330517, DOI: 10.1038/npp.2014.290.
• Novel gene identified in an exome‐wide association study of tanning dependenceCartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome‐wide association study of tanning dependence Experimental Dermatology 2014, 23: 757-759. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.
• Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypesRichardson TG, Minica C, Heron J, Tavare J, MacKenzie A, Day I, Lewis G, Hickman M, Vink JM, Gelernter J, Kranzler HR, Farrer LA, Munafò M, Wynick D. Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 654-664. PMID: 25228436, PMCID: PMC4388908, DOI: 10.1002/ajmg.b.32270.
• Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-AmericansGelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans Biological Psychiatry 2014, 77: 493-503. PMID: 25555482, PMCID: PMC4386684, DOI: 10.1016/j.biopsych.2014.08.025.
• Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in HumansRepunte-Canonigo V, Herman MA, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP. Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans Biological Psychiatry 2014, 77: 870-879. PMID: 25483400, PMCID: PMC4428692, DOI: 10.1016/j.biopsych.2014.07.031.
• Genetics of Complex Traits in PsychiatryGelernter J. Genetics of Complex Traits in Psychiatry Biological Psychiatry 2014, 77: 36-42. PMID: 25444161, PMCID: PMC4282183, DOI: 10.1016/j.biopsych.2014.08.005.
• Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathwaysZhang H, Wang F, Xu H, Liu Y, Liu J, Zhao H, Gelernter J. Differentially co-expressed genes in postmortem prefrontal cortex of individuals with alcohol use disorders: influence on alcohol metabolism-related pathways Human Genetics 2014, 133: 1383-1394. PMID: 25073604, PMCID: PMC4185230, DOI: 10.1007/s00439-014-1473-x.
• Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.Kilcoyne B, Shmulewitz D, Meyers JL, Aharonovich E, Greenstein E, Frisch A, Weizman A, Spivak B, Edenberg HJ, Gelernter J, Hasin DS. Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria. Journal Of Studies On Alcohol And Drugs 2014, 75: 635-42. PMID: 24988262, PMCID: PMC4108604, DOI: 10.15288/jsad.2014.75.635.
• Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genesZhang H, Wang F, Kranzler HR, Yang C, Xu H, Wang Z, Zhao H, Gelernter J. Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes Human Genetics 2014, 133: 1093-1104. PMID: 24889829, PMCID: PMC4127343, DOI: 10.1007/s00439-014-1452-2.
• Genetic risk prediction and neurobiological understanding of alcoholismLevey DF, Le-Niculescu H, Frank J, Ayalew M, Jain N, Kirlin B, Learman R, Winiger E, Rodd Z, Shekhar A, Schork N, Kiefe F, Wodarz N, Müller-Myhsok B, Dahmen N, Nöthen M, Sherva R, Farrer L, Smith A, Kranzler H, Rietschel M, Gelernter J, Niculescu A. Genetic risk prediction and neurobiological understanding of alcoholism Translational Psychiatry 2014, 4: e391-e391. PMID: 24844177, PMCID: PMC4035721, DOI: 10.1038/tp.2014.29.
• Characteristics and course of dependence in cocaine-dependent individuals who never used alcohol or marijuana or used cocaine first.Sartor CE, Kranzler HR, Gelernter J. Characteristics and course of dependence in cocaine-dependent individuals who never used alcohol or marijuana or used cocaine first. Journal Of Studies On Alcohol And Drugs 2014, 75: 423-7. PMID: 24766754, PMCID: PMC4002856, DOI: 10.15288/jsad.2014.75.423.
• Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veteransArias AJ, Gelernter J, Gueorguieva R, Ralevski E, Petrakis IL. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans American Journal On Addictions 2014, 23: 288-293. PMID: 24724887, PMCID: PMC4600600, DOI: 10.1111/j.1521-0391.2014.12102.x.
• Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 PolymorphismKranzler HR, Covault J, Feinn R, Armeli S, Tennen H, Arias AJ, Gelernter J, Pond T, Oncken C, Kampman KM. Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 Polymorphism American Journal Of Psychiatry 2014, 171: 445-452. PMID: 24525690, PMCID: PMC3997125, DOI: 10.1176/appi.ajp.2013.13081014.
• Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disordersKos MZ, Glahn DC, Carless MA, Olvera R, McKay DR, Quillen EE, Gelernter J, Chen XD, Deng HW, Kent JW, Dyer TD, Göring HH, Curran JE, Duggirala R, Blangero J, Almasy L. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 294-302. PMID: 24692236, PMCID: PMC4172449, DOI: 10.1002/ajmg.b.32231.
• Methamphetamine‐induced paranoiaKalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Methamphetamine‐induced paranoia Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.
• Genetic Factors in Social Anxiety DisorderStein M, Gelernter J. Genetic Factors in Social Anxiety Disorder 2014, 53-66. DOI: 10.1002/9781118653920.ch3.
• DSM-5 Gambling Disorder: Prevalence and Characteristics in a Substance Use Disorder SampleRennert L, Denis C, Peer K, Lynch KG, Gelernter J, Kranzler HR. DSM-5 Gambling Disorder: Prevalence and Characteristics in a Substance Use Disorder Sample Experimental And Clinical Psychopharmacology 2014, 22: 50-56. PMID: 24490711, PMCID: PMC4019046, DOI: 10.1037/a0034518.
• The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorderJensen KP, Stein MB, Kranzler HR, Yang BZ, Farrer LA, Gelernter J. The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder Translational Psychiatry 2014, 4: e353-e353. PMID: 24473444, PMCID: PMC3905232, DOI: 10.1038/tp.2013.122.
• Child Abuse, Depression, and Methylation in Genes Involved With Stress, Neural Plasticity, and Brain CircuitryWeder N, Zhang H, Jensen K, Yang BZ, Simen A, Jackowski A, Lipschitz D, Douglas-Palumberi H, Ge M, Perepletchikova F, O'Loughlin K, Hudziak JJ, Gelernter J, Kaufman J. Child Abuse, Depression, and Methylation in Genes Involved With Stress, Neural Plasticity, and Brain Circuitry Journal Of The American Academy Of Child & Adolescent Psychiatry 2014, 53: 417-424.e5. PMID: 24655651, PMCID: PMC4126411, DOI: 10.1016/j.jaac.2013.12.025.
• The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disordersJensen KP, Kranzler HR, Stein MB, Gelernter J. The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2014, 165: 175-183. PMID: 24436253, PMCID: PMC4174417, DOI: 10.1002/ajmg.b.32219.
• SLC6A4 polymorphism, population genetics, and psychiatric traitsGelernter J. SLC6A4 polymorphism, population genetics, and psychiatric traits Human Genetics 2014, 133: 459-461. PMID: 24385047, PMCID: PMC3992709, DOI: 10.1007/s00439-013-1412-2.
• Rare Human Nicotinic Acetylcholine Receptor α4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine ReceptorsMcClure-Begley TD, Papke RL, Stone KL, Stokes C, Levy AD, Gelernter J, Xie P, Lindstrom J, Picciotto MR. Rare Human Nicotinic Acetylcholine Receptor α4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine Receptors Journal Of Pharmacology And Experimental Therapeutics 2014, 348: 410-420. PMID: 24385388, PMCID: PMC3935145, DOI: 10.1124/jpet.113.209767.
• A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old YouthBanducci AN, Gomes M, MacPherson L, Lejuez CW, Potenza MN, Gelernter J, Amstadter AB. A Preliminary Examination of the Relationship Between the 5-HTTLPR and Childhood Emotional Abuse on Depressive Symptoms in 10-12-Year-Old Youth Psychological Trauma Theory Research Practice And Policy 2014, 6: 1-7. PMID: 24932352, PMCID: PMC4057058, DOI: 10.1037/a0031121.
• Improving genetic risk prediction by leveraging pleiotropyLi C, Yang C, Gelernter J, Zhao H. Improving genetic risk prediction by leveraging pleiotropy Human Genetics 2013, 133: 639-650. PMID: 24337655, PMCID: PMC3988249, DOI: 10.1007/s00439-013-1401-5.
• Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM‐IV cocaine dependence as traits for genetic association analysisBi J, Gelernter J, Sun J, Kranzler HR. Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM‐IV cocaine dependence as traits for genetic association analysis American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 165: 148-156. PMID: 24339190, PMCID: PMC4152729, DOI: 10.1002/ajmg.b.32216.
• Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variantsYang C, Li C, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants Human Genetics 2013, 133: 617-624. PMID: 24297757, PMCID: PMC3988209, DOI: 10.1007/s00439-013-1399-8.
• ALDH2 is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sampleQuillen EE, Chen X, Almasy L, Yang F, He H, Li X, Wang X, Liu T, Hao W, Deng H, Kranzler HR, Gelernter J. ALDH2 is associated to alcohol dependence and is the major genetic determinant of “daily maximum drinks” in a GWAS study of an isolated rural chinese sample American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 165: 103-110. PMID: 24277619, PMCID: PMC4149216, DOI: 10.1002/ajmg.b.32213.
• Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol DependenceHan S, Yang BZ, Kranzler HR, Liu X, Zhao H, Farrer LA, Boerwinkle E, Potash JB, Gelernter J. Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence American Journal Of Human Genetics 2013, 93: 1027-1034. PMID: 24268660, PMCID: PMC3853414, DOI: 10.1016/j.ajhg.2013.10.021.
• Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular SmokingStephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen L, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang B, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng Y, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi M, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin M, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking Genetic Epidemiology 2013, 37: 846-859. PMID: 24186853, PMCID: PMC3947535, DOI: 10.1002/gepi.21760.
• Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk lociGelernter J, Kranzler HR, Sherva R, Almasy L, Koesterer R, Smith AH, Anton R, Preuss UW, Ridinger M, Rujescu D, Wodarz N, Zill P, Zhao H, Farrer LA. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci Molecular Psychiatry 2013, 19: 41-49. PMID: 24166409, PMCID: PMC4165335, DOI: 10.1038/mp.2013.145.
• Adversity, ADH1B and alcoholMeyers JL, Shmulewitz D, Wall MM, Keyes KM, Aharonovich E, Spivak B, Weizman A, Frisch A, Edenberg HJ, Gelernter J, Grant BF, Hasin D. Adversity, ADH1B and alcohol Addiction Biology 2013, 20: 205-214. PMID: 24164917, PMCID: PMC3999313, DOI: 10.1111/adb.12102.
• Sex-biased methylome and transcriptome in human prefrontal cortexXu H, Wang F, Liu Y, Yu Y, Gelernter J, Zhang H. Sex-biased methylome and transcriptome in human prefrontal cortex Human Molecular Genetics 2013, 23: 1260-1270. PMID: 24163133, PMCID: PMC3919013, DOI: 10.1093/hmg/ddt516.
• Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium PathwaysGelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways Biological Psychiatry 2013, 76: 66-74. PMID: 24143882, PMCID: PMC3992201, DOI: 10.1016/j.biopsych.2013.08.034.
• Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use DisorderLi D, Sulovari A, Cheng C, Zhao H, Kranzler HR, Gelernter J. Association of Gamma-Aminobutyric Acid A Receptor α2 Gene (GABRA2) with Alcohol Use Disorder Neuropsychopharmacology 2013, 39: 907-918. PMID: 24136292, PMCID: PMC3924525, DOI: 10.1038/npp.2013.291.
• Rate of progression from first use to dependence on cocaine or opioids: A cross-substance examination of associated demographic, psychiatric, and childhood risk factorsSartor CE, Kranzler HR, Gelernter J. Rate of progression from first use to dependence on cocaine or opioids: A cross-substance examination of associated demographic, psychiatric, and childhood risk factors Addictive Behaviors 2013, 39: 473-479. PMID: 24238782, PMCID: PMC3855905, DOI: 10.1016/j.addbeh.2013.10.021.
• Variant Callers for Next-Generation Sequencing Data: A Comparison StudyLiu X, Han S, Wang Z, Gelernter J, Yang BZ. Variant Callers for Next-Generation Sequencing Data: A Comparison Study PLOS ONE 2013, 8: e75619. PMID: 24086590, PMCID: PMC3785481, DOI: 10.1371/journal.pone.0075619.
• Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veteransArias A, Gelernter J, Gueorguieva R, Ralevski E, Petrakis I. Pharmacogenetics of naltrexone and disulfiram in alcohol dependent, dually diagnosed veterans American Journal On Addictions 2013 DOI: 10.1111/j.1521-0391.2013.12102.x.
• Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell CarcinomaCartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma JAMA Dermatology 2013, 149: 1110-1111. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.
• Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adultsWhite S, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J, Williamson V, McMichael O, Vladimirov VI, Amstadter AB. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults Journal Of Anxiety Disorders 2013, 27: 678-683. PMID: 24077033, PMCID: PMC4182958, DOI: 10.1016/j.janxdis.2013.08.003.
• Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk geneGelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene Molecular Psychiatry 2013, 19: 717-723. PMID: 23958962, PMCID: PMC3865158, DOI: 10.1038/mp.2013.99.
• Alcohol‐Metabolizing Genes and Alcohol Phenotypes in an Israeli Household SampleMeyers JL, Shmulewitz D, Aharonovich E, Waxman R, Frisch A, Weizman A, Spivak B, Edenberg HJ, Gelernter J, Hasin DS. Alcohol‐Metabolizing Genes and Alcohol Phenotypes in an Israeli Household Sample Alcoholism Clinical And Experimental Research 2013, 37: 1872-1881. PMID: 23895337, PMCID: PMC3812252, DOI: 10.1111/acer.12176.
• Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use DisordersWang F, Gelernter J, Zhang H. Differential Expression of miR-130a in Postmortem Prefrontal Cortex of Subjects with Alcohol Use Disorders Journal Of Addiction Research & Therapy 2013, 4 PMID: 25383235, PMCID: PMC4221234, DOI: 10.4172/2155-6105.1000155.
• DISC1 affects opioid abuseXie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. DISC1 affects opioid abuse Addiction Biology 2013, 19: 955-964. PMID: 23855403, PMCID: PMC3815683, DOI: 10.1111/adb.12072.
• Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy ControlsZhang H, Wang F, Kranzler HR, Zhao H, Gelernter J. Profiling of Childhood Adversity-Associated DNA Methylation Changes in Alcoholic Patients and Healthy Controls PLOS ONE 2013, 8: e65648. PMID: 23799031, PMCID: PMC3683055, DOI: 10.1371/journal.pone.0065648.
• Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress DisorderXie P, Kranzler HR, Yang C, Zhao H, Farrer LA, Gelernter J. Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder Biological Psychiatry 2013, 74: 656-663. PMID: 23726511, PMCID: PMC3810148, DOI: 10.1016/j.biopsych.2013.04.013.
• COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokersHerman AI, Jatlow PI, Gelernter J, Listman JB, Sofuoglu M. COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers The Pharmacogenomics Journal 2013, 13: 490-497. PMID: 23459442, PMCID: PMC3675163, DOI: 10.1038/tpj.2013.1.
• Child Abuse and Epigenetic Mechanisms of Disease RiskYang BZ, Zhang H, Ge W, Weder N, Douglas-Palumberi H, Perepletchikova F, Gelernter J, Kaufman J. Child Abuse and Epigenetic Mechanisms of Disease Risk American Journal Of Preventive Medicine 2013, 44: 101-107. PMID: 23332324, PMCID: PMC3758252, DOI: 10.1016/j.amepre.2012.10.012.
• Support for association of RORA variant and post traumatic stress symptoms in a population-based study of hurricane exposed adultsAmstadter AB, Sumner JA, Acierno R, Ruggiero KJ, Koenen KC, Kilpatrick DG, Galea S, Gelernter J. Support for association of RORA variant and post traumatic stress symptoms in a population-based study of hurricane exposed adults Molecular Psychiatry 2013, 18: 1148-1149. PMID: 23319003, PMCID: PMC3977702, DOI: 10.1038/mp.2012.189.
• A Complex Interplay between Personality Domains, Marital Status and a Variant in CHRNA5 on the Risks of Cocaine, Nicotine Dependences and Cocaine-Induced ParanoiaZayats T, Yang BZ, Xie P, Poling J, Farrer LA, Gelernter J. A Complex Interplay between Personality Domains, Marital Status and a Variant in CHRNA5 on the Risks of Cocaine, Nicotine Dependences and Cocaine-Induced Paranoia PLOS ONE 2013, 8: e49368. PMID: 23308091, PMCID: PMC3538653, DOI: 10.1371/journal.pone.0049368.
• The Role and Challenges of Exome Sequencing in Studies of Human DiseasesWang Z, Liu X, Yang BZ, Gelernter J. The Role and Challenges of Exome Sequencing in Studies of Human Diseases Frontiers In Genetics 2013, 4: 160. PMID: 24032039, PMCID: PMC3752524, DOI: 10.3389/fgene.2013.00160.
• Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-AmericansHan S, Gelernter J, Kranzler HR, Yang BZ. Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans Human Genetics 2012, 132: 397-403. PMID: 23239122, PMCID: PMC3751162, DOI: 10.1007/s00439-012-1255-2.
• Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: A pilot studyPietrzak RH, Galea S, Southwick SM, Gelernter J. Examining the relation between the serotonin transporter 5-HTTPLR genotype x trauma exposure interaction on a contemporary phenotypic model of posttraumatic stress symptomatology: A pilot study Journal Of Affective Disorders 2012, 148: 123-128. PMID: 23183127, PMCID: PMC3604029, DOI: 10.1016/j.jad.2012.11.003.
• Identification of POMC Exonic Variants Associated with Substance Dependence and Body Mass IndexWang F, Gelernter J, Kranzler HR, Zhang H. Identification of POMC Exonic Variants Associated with Substance Dependence and Body Mass Index PLOS ONE 2012, 7: e45300. PMID: 23028917, PMCID: PMC3444488, DOI: 10.1371/journal.pone.0045300.
• Array‐Based Profiling of DNA Methylation Changes Associated with Alcohol DependenceZhang H, Herman AI, Kranzler HR, Anton RF, Zhao H, Zheng W, Gelernter J. Array‐Based Profiling of DNA Methylation Changes Associated with Alcohol Dependence Alcoholism Clinical And Experimental Research 2012, 37: e108-e115. PMID: 22924764, PMCID: PMC3511647, DOI: 10.1111/j.1530-0277.2012.01928.x.
• Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependenceZhang H, Herman AI, Kranzler HR, Anton RF, Simen AA, Gelernter J. Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence Journal Of Human Genetics 2012, 57: 670-675. PMID: 22914673, PMCID: PMC3481015, DOI: 10.1038/jhg.2012.98.
• GABRA2 Genotype, Impulsivity, and Body MassBauer LO, Yang B, Houston RJ, Kranzler HR, Gelernter J. GABRA2 Genotype, Impulsivity, and Body Mass American Journal On Addictions 2012, 21: 404-410. PMID: 22882390, PMCID: PMC3773931, DOI: 10.1111/j.1521-0391.2012.00252.x.
• Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent samplePeer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR. Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample Drug And Alcohol Dependence 2012, 127: 215-219. PMID: 22884164, PMCID: PMC3727225, DOI: 10.1016/j.drugalcdep.2012.07.009.
• Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset SmokersHartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann H, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, Bierut LJ. Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers JAMA Psychiatry 2012, 69: 854-860. PMID: 22868939, PMCID: PMC3482121, DOI: 10.1001/archgenpsychiatry.2012.124.
• Serotonin transporter 5‐HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: A replication studyXie P, Kranzler HR, Farrer L, Gelernter J. Serotonin transporter 5‐HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: A replication study American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 644-652. PMID: 22693124, PMCID: PMC3428016, DOI: 10.1002/ajmg.b.32068.
• Biases and Errors on Allele Frequency Estimation and Disease Association Tests of Next‐Generation Sequencing of Pooled SamplesChen X, Listman JB, Slack FJ, Gelernter J, Zhao H. Biases and Errors on Allele Frequency Estimation and Disease Association Tests of Next‐Generation Sequencing of Pooled Samples Genetic Epidemiology 2012, 36: 549-560. PMID: 22674656, PMCID: PMC3477622, DOI: 10.1002/gepi.21648.
• Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot studyJamadar S, Powers NR, Meda SA, Calhoun VD, Gelernter J, Gruen JR, Pearlson GD. Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study Brain Imaging And Behavior 2012, 7: 15-27. PMID: 22669497, PMCID: PMC4428558, DOI: 10.1007/s11682-012-9168-1.
• Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviorsSun J, Bi J, Chan G, Oslin D, Farrer L, Gelernter J, Kranzler HR. Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors Addictive Behaviors 2012, 37: 1138-1144. PMID: 22694982, PMCID: PMC3395719, DOI: 10.1016/j.addbeh.2012.05.010.
• Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnosesZhang H, Wang F, Kranzler HR, Anton RF, Gelernter J. Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses Behavioral And Brain Functions 2012, 8: 23. PMID: 22591552, PMCID: PMC3406967, DOI: 10.1186/1744-9081-8-23.
• The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sexAmstadter AB, MacPherson L, Wang F, Banducci AN, Reynolds EK, Potenza MN, Gelernter J, Lejuez CW. The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex Journal Of Psychiatric Research 2012, 46: 940-945. PMID: 22575334, PMCID: PMC3687344, DOI: 10.1016/j.jpsychires.2012.04.010.
• Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African AmericansHan S, Yang BZ, Kranzler HR, Oslin D, Anton R, Farrer LA, Gelernter J. Linkage Analysis Followed by Association Show NRG1 Associated with Cannabis Dependence in African Americans Biological Psychiatry 2012, 72: 637-644. PMID: 22520967, PMCID: PMC3699339, DOI: 10.1016/j.biopsych.2012.02.038.
• Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseasesLi D, Zhao H, Gelernter J. Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases Human Genetics 2012, 131: 1361-1374. PMID: 22476623, PMCID: PMC3557796, DOI: 10.1007/s00439-012-1163-5.
• Meta-analyses of genome-wide linkage scans of anxiety-related phenotypesWebb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM. Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes European Journal Of Human Genetics 2012, 20: 1078-1084. PMID: 22473089, PMCID: PMC3449070, DOI: 10.1038/ejhg.2012.47.
• ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chen XD, Xiong DH, Yang TL, Pei YF, Guo YF, Li J, Yang F, Pan F, Tan LJ, Yan H, Liu XG, Lei SF, Li X, Ning LL, Zhu XZ, Levy S, Kranzler HR, Farrer LA, Gelernter J, Recker RR, Deng HW. ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior. Chinese Medical Journal 2012, 125: 1127-34. PMID: 22613542, PMCID: PMC4174677.
• Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substancesYang B, Han S, Kranzler HR, Farrer LA, Elston RC, Gelernter J. Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 361-369. PMID: 22354695, PMCID: PMC3920832, DOI: 10.1002/ajmg.b.32037.
• Association of COL25A1 with Comorbid Antisocial Personality Disorder and Substance DependenceLi D, Zhao H, Kranzler HR, Oslin D, Anton RF, Farrer LA, Gelernter J. Association of COL25A1 with Comorbid Antisocial Personality Disorder and Substance Dependence Biological Psychiatry 2012, 71: 733-740. PMID: 22297151, PMCID: PMC3548659, DOI: 10.1016/j.biopsych.2011.12.011.
• ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine ExposureChen J, Brunzell DH, Jackson K, van der Vaart A, Z. J, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, Holmans P, Aggen SH, Damaj I, Kuo PH, Webb BT, Anton R, Kranzler HR, Gelernter J, Li MD, Kendler KS, Chen X. ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure PLOS ONE 2011, 6: e28790. PMID: 22205969, PMCID: PMC3243669, DOI: 10.1371/journal.pone.0028790.
• Variation in OPRM1 and Risk of Suicidal Behavior in Drug‐Dependent IndividualsArias AJ, Chan G, Gelernter J, Farrer L, Kranzler HR. Variation in OPRM1 and Risk of Suicidal Behavior in Drug‐Dependent Individuals American Journal On Addictions 2011, 21: 5-10. PMID: 22211341, PMCID: PMC3674102, DOI: 10.1111/j.1521-0391.2011.00195.x.
• M3: an improved SNP calling algorithm for Illumina BeadArray dataLi G, Gelernter J, Kranzler HR, Zhao H. M3: an improved SNP calling algorithm for Illumina BeadArray data Bioinformatics 2011, 28: 358-365. PMID: 22155947, PMCID: PMC3268244, DOI: 10.1093/bioinformatics/btr673.
• GABRA2 and KIBRA genotypes predict early relapse to substance useBauer LO, Covault J, Gelernter J. GABRA2 and KIBRA genotypes predict early relapse to substance use Drug And Alcohol Dependence 2011, 123: 154-159. PMID: 22129841, PMCID: PMC3294190, DOI: 10.1016/j.drugalcdep.2011.11.004.
• Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in AsiansLi D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians Human Genetics 2011, 131: 725-737. PMID: 22102315, PMCID: PMC3548401, DOI: 10.1007/s00439-011-1116-4.
• The association of genetic variation in CACNA1C with structure and function of a frontotemporal systemWang F, McIntosh AM, He Y, Gelernter J, Blumberg HP. The association of genetic variation in CACNA1C with structure and function of a frontotemporal system Bipolar Disorders 2011, 13: 696-700. PMID: 22085483, PMCID: PMC3233238, DOI: 10.1111/j.1399-5618.2011.00963.x.
• Genetic associations with performance on a behavioral measure of distress intoleranceAmstadter AB, Daughters SB, MacPherson L, Reynolds EK, Danielson CK, Wang F, Potenza MN, Gelernter J, Lejuez CW. Genetic associations with performance on a behavioral measure of distress intolerance Journal Of Psychiatric Research 2011, 46: 87-94. PMID: 22024485, PMCID: PMC3687355, DOI: 10.1016/j.jpsychires.2011.09.017.
• Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with α5 Nicotinic Acetylcholine Receptor Genotype Specifically in MalesXie P, Kranzler HR, Zhang H, Oslin D, Anton RF, Farrer LA, Gelernter J. Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with α5 Nicotinic Acetylcholine Receptor Genotype Specifically in Males Neuropsychopharmacology 2011, 37: 669-676. PMID: 22012472, PMCID: PMC3260970, DOI: 10.1038/npp.2011.240.
• A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African‐American womenKranzler HR, Feinn R, Nelson EC, Covault J, Anton RF, Farrer L, Gelernter J. A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African‐American women American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 960-968. PMID: 21998007, PMCID: PMC3227028, DOI: 10.1002/ajmg.b.31243.
• 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorderDouglas K, Chan G, Gelernter J, Arias AJ, Anton RF, Poling J, Farrer L, Kranzler HR. 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder Psychiatric Genetics 2011, 21: 240-248. PMID: 21399568, PMCID: PMC3119731, DOI: 10.1097/ypg.0b013e3283457c15.
• Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1qZuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q Neuropsychopharmacology 2011, 37: 557-566. PMID: 21956439, PMCID: PMC3242317, DOI: 10.1038/npp.2011.229.
• GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African AmericansIttiwut C, Yang B, Kranzler HR, Anton RF, Hirunsatit R, Weiss RD, Covault J, Farrer LA, Gelernter J. GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans Alcoholism Clinical And Experimental Research 2011, 36: 588-593. PMID: 21919924, PMCID: PMC3250564, DOI: 10.1111/j.1530-0277.2011.01637.x.
• No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samplesChang SC, Xie P, Anton RF, De Vivo I, Farrer LA, Kranzler HR, Oslin D, Purcell SM, Roberts AL, Smoller JW, Uddin M, Gelernter J, Koenen KC. No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples Molecular Psychiatry 2011, 17: 239-241. PMID: 21912390, DOI: 10.1038/mp.2011.118.
• A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two PopulationsYang BZ, Han S, Kranzler HR, Farrer LA, Gelernter J. A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two Populations Neuropsychopharmacology 2011, 36: 2422-2430. PMID: 21849985, PMCID: PMC3194068, DOI: 10.1038/npp.2011.122.
• Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine DependenceXie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence Biological Psychiatry 2011, 70: 528-536. PMID: 21683344, PMCID: PMC3199609, DOI: 10.1016/j.biopsych.2011.04.017.
• Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populationsIttiwut R, Listman JB, Ittiwut C, Cubells JF, Weiss RD, Brady K, Oslin D, Farrer LA, Kranzler HR, Gelernter J. Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populations American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 651-660. PMID: 21656904, PMCID: PMC3864552, DOI: 10.1002/ajmg.b.31205.
• Empirically derived subtypes of opioid use and related behaviorsChan G, Gelernter J, Oslin D, Farrer L, Kranzler HR. Empirically derived subtypes of opioid use and related behaviors Addiction 2011, 106: 1146-1154. PMID: 21306596, PMCID: PMC3164489, DOI: 10.1111/j.1360-0443.2011.03390.x.
• Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophreniaJamadar S, Powers NR, Meda SA, Gelernter J, Gruen JR, Pearlson GD. Genetic influences of cortical gray matter in language-related regions in healthy controls and schizophrenia Schizophrenia Research 2011, 129: 141-148. PMID: 21507613, PMCID: PMC3110636, DOI: 10.1016/j.schres.2011.03.027.
• Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical DiseasesLi D, Zhao H, Gelernter J. Strong Association of the Alcohol Dehydrogenase 1B Gene (ADH1B) with Alcohol Dependence and Alcohol-Induced Medical Diseases Biological Psychiatry 2011, 70: 504-512. PMID: 21497796, PMCID: PMC3142297, DOI: 10.1016/j.biopsych.2011.02.024.
• Basic Methods for Clinical Molecular Genetics of Psychiatric IllnessGelernter J, Lappalainen J. Basic Methods for Clinical Molecular Genetics of Psychiatric Illness 2011, 144-157. DOI: 10.1093/med/9780199798261.003.0010.
• Developmental Perspective on the Role of Genes in Smoking RiskGelernter J. Developmental Perspective on the Role of Genes in Smoking Risk Biological Psychiatry 2011, 69: 616-617. PMID: 21397743, PMCID: PMC3252640, DOI: 10.1016/j.biopsych.2011.02.001.
• Association of CHRNA4 polymorphisms with smoking behavior in two populationsHan S, Yang B, Kranzler HR, Oslin D, Anton R, Gelernter J. Association of CHRNA4 polymorphisms with smoking behavior in two populations American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 421-429. PMID: 21445957, PMCID: PMC3742073, DOI: 10.1002/ajmg.b.31177.
• Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primatesJackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates Psychiatry Research 2011, 192: 37-44. PMID: 21377844, PMCID: PMC4090111, DOI: 10.1016/j.pscychresns.2010.11.006.
• Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol DependenceMilivojevic V, Kranzler HR, Gelernter J, Burian L, Covault J. Variation in Genes Encoding the Neuroactive Steroid Synthetic Enzymes 5α‐Reductase Type 1 and 3α‐Reductase Type 2 Is Associated With Alcohol Dependence Alcoholism Clinical And Experimental Research 2011, 35: 946-952. PMID: 21323680, PMCID: PMC3083475, DOI: 10.1111/j.1530-0277.2010.01425.x.
• Variation in NGFB is associated with primary affective disorders in womenCui D, Zhang H, Yang B, Listman JB, Li D, Price LH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation in NGFB is associated with primary affective disorders in women American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 401-412. PMID: 21294249, PMCID: PMC3108453, DOI: 10.1002/ajmg.b.31175.
• Agitated depression in substance dependenceLeventhal AM, Gelernter J, Oslin D, Anton RF, Farrer LA, Kranzler HR. Agitated depression in substance dependence Drug And Alcohol Dependence 2011, 116: 163-169. PMID: 21277711, PMCID: PMC3105217, DOI: 10.1016/j.drugalcdep.2010.12.012.
• Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)Malison RT, Kalayasiri R, Sanichwankul K, Sughondhabirom A, Mutirangura A, Pittman B, Gueorguieva R, Kranzler HR, Gelernter J. Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Addictive Behaviors 2011, 36: 156-160. PMID: 20888699, PMCID: PMC2981662, DOI: 10.1016/j.addbeh.2010.08.031.
• Components of Cross-Frequency Modulation in Health and DiseaseAllen EA, Liu J, Kiehl KA, Gelernter J, Pearlson GD, Perrone-Bizzozero NI, Calhoun VD. Components of Cross-Frequency Modulation in Health and Disease Frontiers In Systems Neuroscience 2011, 5: 59. PMID: 21808609, PMCID: PMC3139214, DOI: 10.3389/fnsys.2011.00059.
• A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Is Associated with Increased Risk for Selective Mutism and Social Anxiety-Related TraitsStein MB, Yang BZ, Chavira DA, Hitchcock CA, Sung SC, Shipon-Blum E, Gelernter J. A Common Genetic Variant in the Neurexin Superfamily Member CNTNAP2 Is Associated with Increased Risk for Selective Mutism and Social Anxiety-Related Traits Biological Psychiatry 2010, 69: 825-831. PMID: 21193173, PMCID: PMC3079072, DOI: 10.1016/j.biopsych.2010.11.008.
• Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholicsHerman AI, Conner TS, Anton RF, Gelernter J, Kranzler HR, Covault J. Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics Addiction Biology 2010, 16: 124-132. PMID: 20192950, PMCID: PMC2888710, DOI: 10.1111/j.1369-1600.2009.00197.x.
• A genomewide ordered-subset linkage analysis for alcohol dependence in African-AmericansHan S, Yang B, Kranzler H, Gelernter J. A genomewide ordered-subset linkage analysis for alcohol dependence in African-Americans Genome Biology 2010, 11: o6. PMCID: PMC3026233, DOI: 10.1186/gb-2010-11-s1-o6.
• Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot studyCoplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study Psychoneuroendocrinology 2010, 36: 289-293. PMID: 20692103, PMCID: PMC3017732, DOI: 10.1016/j.psyneuen.2010.07.011.
• Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPDSaccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X, Landi MT, Z. J, Short SE, Stephens SH, Stevens VL, Sun L, Wang Y, Wenzlaff AS, Aggen SH, Breslau N, Broderick P, Chatterjee N, Chen J, Heath AC, Heliövaara M, Hoft NR, Hunter DJ, Jensen MK, Martin NG, Montgomery GW, Niu T, Payne TJ, Peltonen L, Pergadia ML, Rice JP, Sherva R, Spitz MR, Sun J, Wang JC, Weiss RB, Wheeler W, Witt SH, Yang BZ, Caporaso NE, Ehringer MA, Eisen T, Gapstur SM, Gelernter J, Houlston R, Kaprio J, Kendler KS, Kraft P, Leppert MF, Li MD, Madden PA, Nöthen MM, Pillai S, Rietschel M, Rujescu D, Schwartz A, Amos CI, Bierut LJ. Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD PLOS Genetics 2010, 6: e1001053. PMID: 20700436, PMCID: PMC2916847, DOI: 10.1371/journal.pgen.1001053.
• Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary StudyJagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, Ruaño G, Assaf M, Pearlson GD. Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study Biological Psychiatry 2010, 68: 657-666. PMID: 20691427, PMCID: PMC2990476, DOI: 10.1016/j.biopsych.2010.06.002.
• Serotonin Transporter Gene Associations With Psychopathic Traits in Youth Vary as a Function of Socioeconomic ResourcesSadeh N, Javdani S, Jackson JJ, Reynolds EK, Potenza MN, Gelernter J, Lejuez CW, Verona E. Serotonin Transporter Gene Associations With Psychopathic Traits in Youth Vary as a Function of Socioeconomic Resources Journal Of Psychopathology And Clinical Science 2010, 119: 604-609. PMID: 20677849, PMCID: PMC2916190, DOI: 10.1037/a0019709.
• Variation in the Nicotinic Acetylcholine Receptor Gene Cluster CHRNA5–CHRNA3–CHRNB4 and Its Interaction with Recent Tobacco Use Influence Cognitive FlexibilityZhang H, Kranzler HR, Poling J, Gelernter J. Variation in the Nicotinic Acetylcholine Receptor Gene Cluster CHRNA5–CHRNA3–CHRNB4 and Its Interaction with Recent Tobacco Use Influence Cognitive Flexibility Neuropsychopharmacology 2010, 35: 2211-2224. PMID: 20631687, PMCID: PMC3055317, DOI: 10.1038/npp.2010.95.
• Identification of population substructure among Jews using STR markers and dependence on reference populations includedListman JB, Hasin D, Kranzler HR, Malison RT, Mutirangura A, Sughondhabirom A, Aharonovich E, Spivak B, Gelernter J. Identification of population substructure among Jews using STR markers and dependence on reference populations included BMC Genomic Data 2010, 11: 48. PMID: 20546593, PMCID: PMC2896335, DOI: 10.1186/1471-2156-11-48.
• The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primatesCoplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates Neuroscience Letters 2010, 480: 93-96. PMID: 20541590, PMCID: PMC2951885, DOI: 10.1016/j.neulet.2010.06.012.
• Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence PhenotypesSherva R, Kranzler HR, Yu Y, Logue MW, Poling J, Arias AJ, Anton RF, Oslin D, Farrer LA, Gelernter J. Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes Neuropsychopharmacology 2010, 35: 1921-1931. PMID: 20485328, PMCID: PMC3055642, DOI: 10.1038/npp.2010.64.
• Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress DisorderXie P, Kranzler HR, Poling J, Stein MB, Anton RF, Farrer LA, Gelernter J. Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder Neuropsychopharmacology 2010, 35: 1684-1692. PMID: 20393453, PMCID: PMC2946626, DOI: 10.1038/npp.2010.37.
• A Prospective Cohort Study Investigating Factors Associated With Depression During Medical InternshipSen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship JAMA Psychiatry 2010, 67: 557-565. PMID: 20368500, PMCID: PMC4036806, DOI: 10.1001/archgenpsychiatry.2010.41.
• Genetics of drug dependenceGelernter J, Kranzler HR. Genetics of drug dependence Dialogues In Clinical Neuroscience 2010, 12: 77-84. PMID: 20373669, PMCID: PMC3181942, DOI: 10.31887/dcns.2010.12.1/jgelernter.
• Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter regionZhang H, Gelernter J, Gruen JR, Kranzler HR, Herman AI, Simen AA. Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region Journal Of Human Genetics 2010, 55: 278-284. PMID: 20300121, PMCID: PMC2876206, DOI: 10.1038/jhg.2010.22.
• Confirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10qPanhuysen CI, Kranzler HR, Yu Y, Weiss RD, Brady K, Poling J, Farrer LA, Gelernter J. Confirmation and Generalization of an Alcohol-Dependence Locus on Chromosome 10q Neuropsychopharmacology 2010, 35: 1325-1332. PMID: 20147890, PMCID: PMC2855759, DOI: 10.1038/npp.2010.1.
• Chapter 11 Genetic Basis of Social Anxiety DisorderStein M, Gelernter J. Chapter 11 Genetic Basis of Social Anxiety Disorder 2010, 313-322. DOI: 10.1016/b978-0-12-375096-9.00011-0.
• Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking BehaviorHan S, Gelernter J, Luo X, Yang BZ. Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior Biological Psychiatry 2010, 67: 12-19. PMID: 19819424, PMCID: PMC2975396, DOI: 10.1016/j.biopsych.2009.08.028.
• NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adultsAmstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults Depression And Anxiety 2009, 27: 270-275. PMID: 20037921, PMCID: PMC2879267, DOI: 10.1002/da.20648.
• Arguable Assumptions, Debatable ConclusionsKaufman J, Gelernter J, Kaffman A, Caspi A, Moffitt T. Arguable Assumptions, Debatable Conclusions Biological Psychiatry 2009, 67: e19-e20. PMID: 20006323, PMCID: PMC3784000, DOI: 10.1016/j.biopsych.2009.07.041.
• Association study of DTNBP1 with schizophrenia in a US sampleZuo L, Luo X, Kranzler HR, Lu L, Rosenheck RA, Cramer J, van Kammen DP, Erdos J, Charney DS, Krystal J, Gelernter J. Association study of DTNBP1 with schizophrenia in a US sample Psychiatric Genetics 2009, 19: 292-304. PMID: 19862852, PMCID: PMC2771321, DOI: 10.1097/ypg.0b013e32832a50bc.
• Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic SampleAmstadter AB, Nugent NR, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample Psychiatry 2009, 72: 360-369. PMID: 20070134, PMCID: PMC2808117, DOI: 10.1521/psyc.2009.72.4.360.
• A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophreniaMeda SA, Jagannathan K, Gelernter J, Calhoun VD, Liu J, Stevens MC, Pearlson GD. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia NeuroImage 2009, 53: 1007-1015. PMID: 19944766, PMCID: PMC3968678, DOI: 10.1016/j.neuroimage.2009.11.052.
• Adolescent cannabis use increases risk for cocaine-induced paranoiaKalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT. Adolescent cannabis use increases risk for cocaine-induced paranoia Drug And Alcohol Dependence 2009, 107: 196-201. PMID: 19944543, PMCID: PMC2821949, DOI: 10.1016/j.drugalcdep.2009.10.006.
• Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent PopulationsXie P, Kranzler HR, Poling J, Stein MB, Anton RF, Brady K, Weiss RD, Farrer L, Gelernter J. Interactive Effect of Stressful Life Events and the Serotonin Transporter 5-HTTLPR Genotype on Posttraumatic Stress Disorder Diagnosis in 2 Independent Populations JAMA Psychiatry 2009, 66: 1201-1209. PMID: 19884608, PMCID: PMC2867334, DOI: 10.1001/archgenpsychiatry.2009.153.
• Variation in RGS2 is Associated with Suicidal Ideation in an Epidemiological Study of Adults Exposed to the 2004 Florida HurricanesAmstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Variation in RGS2 is Associated with Suicidal Ideation in an Epidemiological Study of Adults Exposed to the 2004 Florida Hurricanes Archives Of Suicide Research 2009, 13: 349-357. PMID: 19813112, PMCID: PMC2760049, DOI: 10.1080/13811110903266541.
• Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).Tang YL, Kranzler HR, Gelernter J, Farrer LA, Pearson D, Cubells JF. Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP). American Journal On Addictions 2009, 18: 339-45. PMID: 19874151, PMCID: PMC2878659, DOI: 10.3109/10550490903077937.
• Measurement of admixture proportions and description of admixture structure in different U.S. populationsHalder I, Yang B, Kranzler HR, Stein MB, Shriver MD, Gelernter J. Measurement of admixture proportions and description of admixture structure in different U.S. populations Human Mutation 2009, 30: 1299-1309. PMID: 19572378, PMCID: PMC2867064, DOI: 10.1002/humu.21045.
• Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disordersDouglas KR, Chan G, Gelernter J, Arias AJ, Anton RF, Weiss RD, Brady K, Poling J, Farrer L, Kranzler HR. Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders Addictive Behaviors 2009, 35: 7-13. PMID: 19720467, PMCID: PMC2763992, DOI: 10.1016/j.addbeh.2009.07.004.
• Subtypes of major depression in substance dependenceNiciu MJ, Chan G, Gelernter J, Arias AJ, Douglas K, Weiss R, Anton RF, Farrer L, Cubells JF, Kranzler HR. Subtypes of major depression in substance dependence Addiction 2009, 104: 1700-1709. PMID: 19681804, PMCID: PMC2980795, DOI: 10.1111/j.1360-0443.2009.02672.x.
• Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco UseZhang H, Kranzler HR, Poling J, Gruen JR, Gelernter J. Cognitive Flexibility is Associated with KIBRA Variant and Modulated by Recent Tobacco Use Neuropsychopharmacology 2009, 34: 2508-2516. PMID: 19606085, PMCID: PMC2898508, DOI: 10.1038/npp.2009.80.
• Interaction of Childhood Maltreatment with the Corticotropin-Releasing Hormone Receptor Gene: Effects on Hypothalamic-Pituitary-Adrenal Axis ReactivityTyrka AR, Price LH, Gelernter J, Schepker C, Anderson GM, Carpenter LL. Interaction of Childhood Maltreatment with the Corticotropin-Releasing Hormone Receptor Gene: Effects on Hypothalamic-Pituitary-Adrenal Axis Reactivity Biological Psychiatry 2009, 66: 681-685. PMID: 19596121, PMCID: PMC2881567, DOI: 10.1016/j.biopsych.2009.05.012.
• Genetics of alcohol dependenceGelernter J, Kranzler HR. Genetics of alcohol dependence Human Genetics 2009, 126: 91-99. PMID: 19533172, PMCID: PMC3773848, DOI: 10.1007/s00439-009-0701-2.
• ADH1A variation predisposes to personality traits and substance dependenceZuo L, Gelernter J, Kranzler HR, Stein MB, Zhang H, Wei F, Sen S, Poling J, Luo X. ADH1A variation predisposes to personality traits and substance dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2009, 153B: 376-386. PMID: 19526455, PMCID: PMC2861415, DOI: 10.1002/ajmg.b.30990.
• The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variationZuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation Pharmacogenetics And Genomics 2009, 19: 437-446. PMID: 19369910, PMCID: PMC2857717, DOI: 10.1097/fpc.0b013e32832b9cfc.
• A sequencing‐based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controlsAmin Z, Kanarek K, Krupitsky E, Walderhaug E, Ilomäki R, Blumberg H, Price LH, Bhagwagar Z, Carpenter LL, Tyrka AR, Magnusson A, Landrø NI, Zvartau E, Gelernter J, Epperson CN, Räsänen P, Siironen J, Lappalainen J. A sequencing‐based survey of functional APAF1 alleles in a large sample of individuals with affective illness and population controls American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2009, 153B: 332-335. PMID: 19455599, PMCID: PMC3580167, DOI: 10.1002/ajmg.b.30984.
• Sources of unreliability in the diagnosis of substance dependence.Feinn R, Gelernter J, Cubells JF, Farrer L, Kranzler HR. Sources of unreliability in the diagnosis of substance dependence. Journal Of Studies On Alcohol And Drugs 2009, 70: 475-81. PMID: 19371499, PMCID: PMC2670752, DOI: 10.15288/jsad.2009.70.475.
• Population admixture modulates risk for alcohol dependenceZuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.
• Association of Markers in the 3′ Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol DependenceKranzler HR, Gelernter J, Anton RF, Arias AJ, Herman A, Zhao H, Burian L, Covault J. Association of Markers in the 3′ Region of the GluR5 Kainate Receptor Subunit Gene to Alcohol Dependence Alcoholism Clinical And Experimental Research 2009, 33: 925-930. PMID: 19320626, PMCID: PMC2772659, DOI: 10.1111/j.1530-0277.2009.00913.x.
• Association of Variants in MANEA With Cocaine-Related BehaviorsFarrer LA, Kranzler HR, Yu Y, Weiss RD, Brady KT, Anton R, Cubells JF, Gelernter J. Association of Variants in MANEA With Cocaine-Related Behaviors JAMA Psychiatry 2009, 66: 267-274. PMID: 19255376, PMCID: PMC2758158, DOI: 10.1001/archgenpsychiatry.2008.538.
• Pro-Opiomelanocortin Gene Variation Related to Alcohol or Drug Dependence: Evidence and Replications Across Family- and Population-based StudiesZhang H, Kranzler HR, Weiss RD, Luo X, Brady KT, Anton RF, Farrer LA, Gelernter J. Pro-Opiomelanocortin Gene Variation Related to Alcohol or Drug Dependence: Evidence and Replications Across Family- and Population-based Studies Biological Psychiatry 2009, 66: 128-136. PMID: 19217079, PMCID: PMC2896237, DOI: 10.1016/j.biopsych.2008.12.021.
• Genetic variation in 5HTTLPR is associated with emotional resilienceStein MB, Campbell‐Sills L, Gelernter J. Genetic variation in 5HTTLPR is associated with emotional resilience American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2009, 150B: 900-906. PMID: 19152387, PMCID: PMC2885845, DOI: 10.1002/ajmg.b.30916.
• Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social EnvironmentKoenen KC, Aiello AE, Bakshis E, Amstadter AB, Ruggiero KJ, Acierno R, Kilpatrick DG, Gelernter J, Galea S. Modification of the Association Between Serotonin Transporter Genotype and Risk of Posttraumatic Stress Disorder in Adults by County-Level Social Environment American Journal Of Epidemiology 2009, 169: 704-711. PMID: 19228812, PMCID: PMC2727213, DOI: 10.1093/aje/kwn397.
• BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory StudyZdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study Journal Of Alzheimer's Disease 2009, 17: 887-898. PMID: 19542613, PMCID: PMC4084650, DOI: 10.3233/jad-2009-1106.
• Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activityHirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA. Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity Pharmacogenetics And Genomics 2009, 19: 53-65. PMID: 19077666, PMCID: PMC2791799, DOI: 10.1097/fpc.0b013e328318b21a.
• Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposureAmstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure Journal Of Anxiety Disorders 2008, 23: 369-373. PMID: 19162436, PMCID: PMC2735848, DOI: 10.1016/j.janxdis.2008.12.005.
• Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in AdolescentsJacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents Biological Psychiatry 2008, 65: 671-679. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.
• Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon GrowthBudel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth Journal Of Neuroscience 2008, 28: 13161-13172. PMID: 19052207, PMCID: PMC2892845, DOI: 10.1523/jneurosci.3828-08.2008.
• Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based SampleZuo L, Kranzler HR, Luo X, Yang BZ, Weiss R, Brady K, Poling J, Farrer L, Gelernter J. Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample Neuropsychopharmacology 2008, 34: 1504-1513. PMID: 19052543, PMCID: PMC2879626, DOI: 10.1038/npp.2008.206.
• Role of Variation in the Serotonin Transporter Protein Gene (SLC6A4) in Trait Disturbances in the Ventral Anterior Cingulate in Bipolar DisorderShah MP, Wang F, Kalmar JH, Chepenik LG, Tie K, Pittman B, Jones MM, Constable RT, Gelernter J, Blumberg HP. Role of Variation in the Serotonin Transporter Protein Gene (SLC6A4) in Trait Disturbances in the Ventral Anterior Cingulate in Bipolar Disorder Neuropsychopharmacology 2008, 34: 1301-1310. PMID: 19037205, PMCID: PMC2826628, DOI: 10.1038/npp.2008.204.
• MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of TraumaWeder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA Genotype, Maltreatment, and Aggressive Behavior: The Changing Impact of Genotype at Varying Levels of Trauma Biological Psychiatry 2008, 65: 417-424. PMID: 18996506, PMCID: PMC3816252, DOI: 10.1016/j.biopsych.2008.09.013.
• Dense Genomewide Linkage Scan for Alcohol Dependence in African Americans: Significant Linkage on Chromosome 10Gelernter J, Kranzler HR, Panhuysen C, Weiss RD, Brady K, Poling J, Farrer L. Dense Genomewide Linkage Scan for Alcohol Dependence in African Americans: Significant Linkage on Chromosome 10 Biological Psychiatry 2008, 65: 111-115. PMID: 18930185, PMCID: PMC2646253, DOI: 10.1016/j.biopsych.2008.08.036.
• RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adultsKoenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J. RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane‐exposed adults Depression And Anxiety 2008, 26: 309-315. PMID: 18833580, PMCID: PMC2666784, DOI: 10.1002/da.20528.
• Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug DependenceYang B, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence Alcoholism Clinical And Experimental Research 2008, 32: 2117-2127. PMID: 18828801, PMCID: PMC2975565, DOI: 10.1111/j.1530-0277.2008.00800.x.
• Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD testLuo X, Zuo L, Kranzler HR, Wang S, Anton RF, Gelernter J. Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test Behavioral And Brain Functions 2008, 4: 42. PMID: 18801187, PMCID: PMC2563013, DOI: 10.1186/1744-9081-4-42.
• Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individualsFord JD, Gelernter J, DeVoe JS, Zhang W, Weiss RD, Brady K, Farrer L, Kranzler HR. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals Drug And Alcohol Dependence 2008, 99: 193-203. PMID: 18775607, PMCID: PMC2745327, DOI: 10.1016/j.drugalcdep.2008.07.004.
• Influence of Vascular Endothelial Growth Factor Variation on Human Hippocampus MorphologyBlumberg HP, Wang F, Chepenik LG, Kalmar JH, Edmiston E, Duman RS, Gelernter J. Influence of Vascular Endothelial Growth Factor Variation on Human Hippocampus Morphology Biological Psychiatry 2008, 64: 901-903. PMID: 18707678, PMCID: PMC2649728, DOI: 10.1016/j.biopsych.2008.07.003.
• Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar DisorderChepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.
• Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy DrinkersArias AJ, Armeli S, Gelernter J, Covault J, Kallio A, Karhuvaara S, Koivisto T, Mäkelä R, Kranzler HR. Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy Drinkers Alcoholism Clinical And Experimental Research 2008, 32: 1159-1166. PMID: 18537939, PMCID: PMC2950972, DOI: 10.1111/j.1530-0277.2008.00735.x.
• Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disordersArias AJ, Gelernter J, Chan G, Weiss RD, Brady KT, Farrer L, Kranzler HR. Correlates of co-occurring ADHD in drug-dependent subjects: Prevalence and features of substance dependence and psychiatric disorders Addictive Behaviors 2008, 33: 1199-1207. PMID: 18558465, PMCID: PMC2532519, DOI: 10.1016/j.addbeh.2008.05.003.
• Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single ArrayHodgkinson CA, Yuan Q, Xu K, Shen PH, Heinz E, Lobos EA, Binder EB, Cubells J, Ehlers CL, Gelernter J, Mann J, Riley B, Roy A, Tabakoff B, Todd RD, Zhou Z, Goldman D. Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array Alcohol And Alcoholism 2008, 43: 505-515. PMID: 18477577, PMCID: PMC2724863, DOI: 10.1093/alcalc/agn032.
• Substance dependence low-density whole genome association study in two distinct American populationsYu Y, Kranzler HR, Panhuysen C, Weiss RD, Poling J, Farrer LA, Gelernter J. Substance dependence low-density whole genome association study in two distinct American populations Human Genetics 2008, 123: 495. PMID: 18438686, PMCID: PMC3428017, DOI: 10.1007/s00439-008-0501-0.
• It Is Time to Take a Stand for Medical Research and Against Terrorism Targeting Medical ScientistsKrystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O’Brien C, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It Is Time to Take a Stand for Medical Research and Against Terrorism Targeting Medical Scientists Biological Psychiatry 2008, 63: 725-727. PMID: 18371494, DOI: 10.1016/j.biopsych.2008.03.005.
• ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjectsLuo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. ADH7 variation modulates extraversion and conscientiousness in substance‐dependent subjects American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147B: 179-186. PMID: 17918242, PMCID: PMC3160628, DOI: 10.1002/ajmg.b.30589.
• Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain FunctionSmoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB. Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function JAMA Psychiatry 2008, 65: 298-308. PMID: 18316676, DOI: 10.1001/archgenpsychiatry.2007.48.
• Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokersNussbaum J, Xu Q, Payne TJ, Z. J, Huang W, Gelernter J, Li MD. Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers Human Molecular Genetics 2008, 17: 1569-1577. PMID: 18270208, PMCID: PMC2902291, DOI: 10.1093/hmg/ddn044.
• Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus AccumbensPotenza MN, Brodkin ES, Yang BZ, Birnbaum SG, Nestler EJ, Gelernter J. Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens Neuropsychopharmacology 2008, 33: 2735-2746. PMID: 18216777, PMCID: PMC2818767, DOI: 10.1038/sj.npp.1301667.
• Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populationsLuo X, Zuo L, Kranzler H, Zhang H, Wang S, Gelernter J. Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2008, 147B: 1028-1039. PMID: 18213616, PMCID: PMC3162230, DOI: 10.1002/ajmg.b.30701.
• Population-specific effects of the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1) on HPA-axis activationHernandez-Avila CA, Covault J, Wand G, Zhang H, Gelernter J, Kranzler HR. Population-specific effects of the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1) on HPA-axis activation Pharmacogenetics And Genomics 2007, 17: 1031-1038. PMID: 18004207, DOI: 10.1097/fpc.0b013e3282f0b99c.
• Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry StudyMeda SA, Gelernter J, Gruen JR, Calhoun VD, Meng H, Cope NA, Pearlson GD. Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study Brain Imaging And Behavior 2007, 2: 21-26. PMID: 19096528, PMCID: PMC2605089, DOI: 10.1007/s11682-007-9012-1.
• Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J. Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4 Genomics 2007, 91: 61-69. PMID: 17976953, PMCID: PMC2709929, DOI: 10.1016/j.ygeno.2007.08.007.
• The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed AdultsKilpatrick DG, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Resnick HS, Roitzsch J, Boyle J, Gelernter J. The Serotonin Transporter Genotype and Social Support and Moderation of Posttraumatic Stress Disorder and Depression in Hurricane-Exposed Adults American Journal Of Psychiatry 2007, 164: 1693-1699. PMID: 17974934, DOI: 10.1176/appi.ajp.2007.06122007.
• Variation in GABRA2 Predicts Drinking Behavior in Project MATCH SubjectsBauer LO, Covault J, Harel O, Das S, Gelernter J, Anton R, Kranzler HR. Variation in GABRA2 Predicts Drinking Behavior in Project MATCH Subjects Alcoholism Clinical And Experimental Research 2007, 31: 1780-1787. PMID: 17949392, PMCID: PMC3169387, DOI: 10.1111/j.1530-0277.2007.00517.x.
• Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic researchHirunsatit R, Ilomäki R, Malison R, Räsänen P, Ilomäki E, Kranzler HR, Kosten T, Sughondhabirom A, Thavichachart N, Tangwongchai S, Listman J, Mutirangura A, Gelernter J, Lappalainen J. Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research BMC Genomic Data 2007, 8: 71. PMID: 17941974, PMCID: PMC2175509, DOI: 10.1186/1471-2156-8-71.
• Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samplesYang BZ, Kranzler HR, Zhao H, Gruen JR, Luo X, Gelernter J. Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case–control and family samples Human Molecular Genetics 2007, 16: 2844-2853. PMID: 17761687, DOI: 10.1093/hmg/ddm240.
• The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence riskZhang H, Kranzler HR, Yang BZ, Luo X, Gelernter J. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk Molecular Psychiatry 2007, 13: 531-543. PMID: 17622222, PMCID: PMC3163084, DOI: 10.1038/sj.mp.4002035.
• Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)Pierucci-Lagha A, Gelernter J, Chan G, Arias A, Cubells JF, Farrer L, Kranzler HR. Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA) Drug And Alcohol Dependence 2007, 91: 85-90. PMID: 17590536, PMCID: PMC2039919, DOI: 10.1016/j.drugalcdep.2007.04.014.
• The validity of cocaine dependence subtypesKranzler HR, Wilcox M, Weiss RD, Brady K, Hesselbrock V, Rounsaville B, Farrer L, Gelernter J. The validity of cocaine dependence subtypes Addictive Behaviors 2007, 33: 41-53. PMID: 17582692, PMCID: PMC2111173, DOI: 10.1016/j.addbeh.2007.05.011.
• CNR1 Variation Modulates Risk for Drug and Alcohol DependenceZuo L, Kranzler HR, Luo X, Covault J, Gelernter J. CNR1 Variation Modulates Risk for Drug and Alcohol Dependence Biological Psychiatry 2007, 62: 616-626. PMID: 17509535, DOI: 10.1016/j.biopsych.2006.12.004.
• Markers in the 5′-Region of GABRG1 Associate to Alcohol Dependence and are in Linkage Disequilibrium with Markers in the Adjacent GABRA2 GeneCovault J, Gelernter J, Jensen K, Anton R, Kranzler HR. Markers in the 5′-Region of GABRG1 Associate to Alcohol Dependence and are in Linkage Disequilibrium with Markers in the Adjacent GABRA2 Gene Neuropsychopharmacology 2007, 33: 837-848. PMID: 17507911, PMCID: PMC2743531, DOI: 10.1038/sj.npp.1301456.
• Demographic changes and marker properties affect detection of human population differentiationListman JB, Malison RT, Sughondhabirom A, Yang BZ, Raaum RL, Thavichachart N, Sanichwankul K, Kranzler HR, Tangwonchai S, Mutirangura A, Disotell TR, Gelernter J. Demographic changes and marker properties affect detection of human population differentiation BMC Genomic Data 2007, 8: 21. PMID: 17498298, PMCID: PMC1876243, DOI: 10.1186/1471-2156-8-21.
• Gene-by-Environment (Serotonin Transporter and Childhood Maltreatment) Interaction for Anxiety Sensitivity, an Intermediate Phenotype for Anxiety DisordersStein MB, Schork NJ, Gelernter J. Gene-by-Environment (Serotonin Transporter and Childhood Maltreatment) Interaction for Anxiety Sensitivity, an Intermediate Phenotype for Anxiety Disorders Neuropsychopharmacology 2007, 33: 312-319. PMID: 17460615, DOI: 10.1038/sj.npp.1301422.
• CHRM2 variation predisposes to personality traits of agreeableness and conscientiousnessLuo X, Kranzler HR, Zuo L, Zhang H, Wang S, Gelernter J. CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness Human Molecular Genetics 2007, 16: 1557-1568. PMID: 17468496, DOI: 10.1093/hmg/ddm104.
• Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative StudyGelernter J, Gueorguieva R, Kranzler H, Zhang H, Cramer J, Rosenheck R, Krystal J. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study Alcoholism Clinical And Experimental Research 2007, 0: 070212174136005-???. DOI: 10.1111/j.1530-0277.2007.00339.x.
• Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative StudyGelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH, Group T. Opioid Receptor Gene (OPRM1, OPRK1, and OPRD1) Variants and Response to Naltrexone Treatment for Alcohol Dependence: Results From the VA Cooperative Study Alcoholism Clinical And Experimental Research 2007, 31: 555-563. PMID: 17374034, DOI: 10.1111/j.1530-0277.2007.00339.x.
• Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent SubjectsTang Y, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects American Journal On Addictions 2007, 16: 343-351. PMID: 17882604, DOI: 10.1080/10550490701525723.
• Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-AdministrationKalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Lappalainen J, Gelernter J, Cubells JF, Malison RT. Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration Biological Psychiatry 2006, 61: 1310-1313. PMID: 17157269, DOI: 10.1016/j.biopsych.2006.08.012.
• Multiple ADH genes modulate risk for drug dependence in both African- and European-AmericansLuo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans Human Molecular Genetics 2006, 16: 380-390. PMID: 17185388, PMCID: PMC1853246, DOI: 10.1093/hmg/ddl460.
• Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoiaMalison RT, Kranzler HR, Yang BZ, Gelernter J. Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia Psychiatric Genetics 2006, 16: 245-249. PMID: 17106427, DOI: 10.1097/01.ypg.0000242198.59020.ca.
• DOPA decarboxylase gene is associated with nicotine dependenceZhang H, Ye Y, Wang X, Gelernter J, Z J, Li MD. DOPA decarboxylase gene is associated with nicotine dependence Pharmacogenomics 2006, 7: 1159-1166. PMID: 17184203, DOI: 10.2217/14622416.7.8.1159.
• Genetic and Environmental Predictors of Early Alcohol UseKaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J. Genetic and Environmental Predictors of Early Alcohol Use Biological Psychiatry 2006, 61: 1228-1234. PMID: 17123474, DOI: 10.1016/j.biopsych.2006.06.039.
• Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populationsGelernter J, Yu Y, Weiss R, Brady K, Panhuysen C, Yang BZ, Kranzler HR, Farrer L. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations Human Molecular Genetics 2006, 15: 3498-3507. PMID: 17085484, DOI: 10.1093/hmg/ddl426.
• Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk LocusGelernter J, Panhuysen C, Weiss R, Brady K, Poling J, Krauthammer M, Farrer L, Kranzler HR. Genomewide Linkage Scan for Nicotine Dependence: Identification of a Chromosome 5 Risk Locus Biological Psychiatry 2006, 61: 119-126. PMID: 17081504, DOI: 10.1016/j.biopsych.2006.08.023.
• Personality Traits of Agreeableness and Extraversion are Associated with ADH4 VariationLuo X, Kranzler HR, Zuo L, Wang S, Gelernter J. Personality Traits of Agreeableness and Extraversion are Associated with ADH4 Variation Biological Psychiatry 2006, 61: 599-608. PMID: 17069770, PMCID: PMC1853245, DOI: 10.1016/j.biopsych.2006.05.017.
• Mutation screen of the GAD2 gene and association study of alcoholism in three populationsLappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 144B: 183-192. PMID: 17034009, DOI: 10.1002/ajmg.b.30377.
• γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and TreatmentKrystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.
• C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiencyJacobsen LK, Pugh KR, Mencl WE, Gelernter J. C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency Psychopharmacology 2006, 188: 530-540. PMID: 16896957, DOI: 10.1007/s00213-006-0469-1.
• Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's DiseaseZdanys KF, Kleiman TG, MacAvoy MG, Black BT, Rightmer TE, Grey M, Garman KS, Tampi RR, Gelernter J, van Dyck CH. Apolipoprotein E ɛ4 Allele Increases Risk for Psychotic Symptoms in Alzheimer's Disease Neuropsychopharmacology 2006, 32: 171-179. PMID: 16841077, DOI: 10.1038/sj.npp.1301148.
• Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependenceHerman AI, Kranzler HR, Cubells JF, Gelernter J, Covault J. Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 141B: 499-503. PMID: 16741937, PMCID: PMC2574012, DOI: 10.1002/ajmg.b.30325.
• Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective AnalysisKleiman T, Zdanys K, Black B, Rightmer T, Grey M, Garman K, MacAvoy M, Gelernter J, van Dyck C. Apolipoprotein E ε4 Allele Is Unrelated to Cognitive or Functional Decline in Alzheimer’s Disease: Retrospective and Prospective Analysis Dementia And Geriatric Cognitive Disorders 2006, 22: 73-82. PMID: 16699282, DOI: 10.1159/000093316.
• Intronic variants in the dopa decarboxylase ( DDC ) gene are associated with smoking behavior in European-Americans and African-AmericansYu Y, Panhuysen C, Kranzler HR, Hesselbrock V, Rounsaville B, Weiss R, Brady K, Farrer LA, Gelernter J. Intronic variants in the dopa decarboxylase ( DDC ) gene are associated with smoking behavior in European-Americans and African-Americans Human Molecular Genetics 2006, 15: 2192-2199. PMID: 16740595, DOI: 10.1093/hmg/ddl144.
• Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependenceZhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Price LH, Southwick S, Yang B, Rasmussen A, Gelernter J. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2006, 141B: 387-393. PMID: 16649215, PMCID: PMC2567822, DOI: 10.1002/ajmg.b.30332.
• Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol DependenceLuo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J. Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence American Journal Of Human Genetics 2006, 78: 973-987. PMID: 16685648, PMCID: PMC1474098, DOI: 10.1086/504113.
• Variation at APOE and STH loci and Alzheimer's diseaseZuo L, van Dyck CH, Luo X, Kranzler HR, Yang BZ, Gelernter J. Variation at APOE and STH loci and Alzheimer's disease Behavioral And Brain Functions 2006, 2: 13. PMID: 16603077, PMCID: PMC1526745, DOI: 10.1186/1744-9081-2-13.
• Genomewide Linkage Scan for Opioid Dependence and Related TraitsGelernter J, Panhuysen C, Wilcox M, Hesselbrock V, Rounsaville B, Poling J, Weiss R, Sonne S, Zhao H, Farrer L, Kranzler HR. Genomewide Linkage Scan for Opioid Dependence and Related Traits American Journal Of Human Genetics 2006, 78: 759-769. PMID: 16642432, PMCID: PMC1474044, DOI: 10.1086/503631.
• Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorderStein MB, Seedat S, Gelernter J. Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder Psychopharmacology 2006, 187: 68-72. PMID: 16525856, DOI: 10.1007/s00213-006-0349-8.
• GENETIC STUDY: Analysis of variations in the tryptophan hydroxylase‐2 (TPH2) gene in cocaine dependenceDahl JP, Cubells JF, Ray R, Weller AE, Lohoff FW, Ferraro TN, Oslin DW, Kampman KM, Dackis C, Tang Y, Gelernter J, Kranzler HR, O’Brien C, Berrettini WH. GENETIC STUDY: Analysis of variations in the tryptophan hydroxylase‐2 (TPH2) gene in cocaine dependence Addiction Biology 2006, 11: 76-83. PMID: 16759340, DOI: 10.1111/j.1369-1600.2006.00005.x.
• Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependenceZhang H, Luo X, Kranzler HR, Lappalainen J, Yang BZ, Krupitsky E, Zvartau E, Gelernter J. Association between two µ-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence Human Molecular Genetics 2006, 15: 807-819. PMID: 16476706, PMCID: PMC3164878, DOI: 10.1093/hmg/ddl024.
• Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in ChildrenKaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.
• Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk LocusKaabi B, Gelernter J, Woods SW, Goddard A, Page GP, Elston RC. Genome Scan for Loci Predisposing to Anxiety Disorders Using a Novel Multivariate Approach: Strong Evidence for a Chromosome 4 Risk Locus American Journal Of Human Genetics 2006, 78: 543-553. PMID: 16532386, PMCID: PMC1424685, DOI: 10.1086/501072.
• Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairsKalayasiri R, Kranzler HR, Weiss R, Brady K, Gueorguieva R, Panhuysen C, Yang BZ, Farrer L, Gelernter J, Malison RT. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs Drug And Alcohol Dependence 2006, 84: 77-84. PMID: 16413147, DOI: 10.1016/j.drugalcdep.2005.12.002.
• Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA)Pierucci-Lagha A, Gelernter J, Feinn R, Cubells JF, Pearson D, Pollastri A, Farrer L, Kranzler HR. Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) Drug And Alcohol Dependence 2005, 80: 303-312. PMID: 15896927, DOI: 10.1016/j.drugalcdep.2005.04.005.
• DCDC2 is associated with reading disability and modulates neuronal development in the brainMeng H, Smith SD, Hager K, Held M, Liu J, Olson RK, Pennington BF, DeFries JC, Gelernter J, O'Reilly-Pol T, Somlo S, Skudlarski P, Shaywitz SE, Shaywitz BA, Marchione K, Wang Y, Paramasivam M, LoTurco JJ, Page GP, Gruen JR. DCDC2 is associated with reading disability and modulates neuronal development in the brain Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 17053-17058. PMID: 16278297, PMCID: PMC1278934, DOI: 10.1073/pnas.0508591102.
• ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studiesLuo X, Kranzler HR, Zuo L, Yang BZ, Lappalainen J, Gelernter J. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies Pharmacogenetics And Genomics 2005, 15: 755-768. PMID: 16220108, DOI: 10.1097/01.fpc.0000180141.77036.dc.
• Incentive Program Decreases No-Shows in Nontreatment Substance Abuse ResearchPollastri AR, Pokrywa ML, Walsh SJ, Kranzler HR, Gelernter J. Incentive Program Decreases No-Shows in Nontreatment Substance Abuse Research Experimental And Clinical Psychopharmacology 2005, 13: 376-380. PMID: 16366768, DOI: 10.1037/1064-1297.13.4.376.
• Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignmentYang BZ, Zhao H, Kranzler HR, Gelernter J. Characterization of a likelihood based method and effects of markers informativeness in evaluation of admixture and population group assignment BMC Genomic Data 2005, 6: 50. PMID: 16225681, PMCID: PMC1285360, DOI: 10.1186/1471-2156-6-50.
• ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association StudiesLuo X, Kranzler HR, Zuo L, Lappalainen J, Yang BZ, Gelernter J. ADH4 Gene Variation is Associated with Alcohol Dependence and Drug Dependence in European Americans: Results from HWD Tests and Case–Control Association Studies Neuropsychopharmacology 2005, 31: 1085-1095. PMID: 16237392, DOI: 10.1038/sj.npp.1300925.
• Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)Cubells JF, Feinn R, Pearson D, Burda J, Tang Y, Farrer LA, Gelernter J, Kranzler HR. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP) Drug And Alcohol Dependence 2005, 80: 23-33. PMID: 15894433, DOI: 10.1016/j.drugalcdep.2005.03.019.
• Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's diseaseBasso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease Neurobiology Of Aging 2005, 27: 1416-1424. PMID: 16182410, DOI: 10.1016/j.neurobiolaging.2005.08.002.
• CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case–control structured association studyLuo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case–control structured association study Human Molecular Genetics 2005, 14: 2421-2434. PMID: 16000316, DOI: 10.1093/hmg/ddi244.
• COMT Polymorphisms and Anxiety-Related Personality TraitsStein MB, Fallin MD, Schork NJ, Gelernter J. COMT Polymorphisms and Anxiety-Related Personality Traits Neuropsychopharmacology 2005, 30: 2092-2102. PMID: 15956988, DOI: 10.1038/sj.npp.1300787.
• Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoiaGelernter J, Panhuysen C, Weiss R, Brady K, Hesselbrock V, Rounsaville B, Poling J, Wilcox M, Farrer L, Kranzler HR. Genomewide linkage scan for cocaine dependence and related traits: Significant linkages for a cocaine‐related trait and cocaine‐induced paranoia American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 45-52. PMID: 15909294, DOI: 10.1002/ajmg.b.30189.
• Response to Dr. Kopke's comments on haplotypes at the OPRM1 locusLuo X, Gelernter J, Zhao H, Kranzler HR. Response to Dr. Kopke's comments on haplotypes at the OPRM1 locus American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 135B: 102-102. PMID: 15806579, DOI: 10.1002/ajmg.b.30060.
• Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal Of Nuclear Medicine 2005, 46: 745-51. PMID: 15872345.
• Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTUREYang B, Zhao H, Kranzler HR, Gelernter J. Practical population group assignment with selected informative markers: Characteristics and properties of Bayesian clustering via STRUCTURE Genetic Epidemiology 2005, 28: 302-312. PMID: 15782414, DOI: 10.1002/gepi.20070.
• Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian PopulationLappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association Between Alcoholism and γ‐Amino Butyric Acid α2 Receptor Subtype in a Russian Population Alcoholism Clinical And Experimental Research 2005, 29: 493-498. PMID: 15834213, DOI: 10.1097/01.alc.0000158938.97464.90.
• Social supports and serotonin transporter gene moderate depression in maltreated childrenKaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 17316-17321. PMID: 15563601, PMCID: PMC534414, DOI: 10.1073/pnas.0404376101.
• Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to AlcoholismPetrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism American Journal Of Psychiatry 2004, 161: 1776-1782. PMID: 15465973, DOI: 10.1176/ajp.161.10.1776.
• Allelic and haplotypic association of GABRA2 with alcohol dependenceCovault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.
• A polymorphism of the β1-adrenergic receptor is associated with low extraversionStein MB, Schork NJ, Gelernter J. A polymorphism of the β1-adrenergic receptor is associated with low extraversion Biological Psychiatry 2004, 56: 217-224. PMID: 15312808, DOI: 10.1016/j.biopsych.2004.05.020.
• Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smokingGelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 128B: 94-101. PMID: 15211640, DOI: 10.1002/ajmg.b.30019.
• Setting Priorities for Genomic ResearchBerrettini W, Bierut L, Crowley TJ, Cubells JF, Frascella J, Gelernter J, Hewitt JK, Kreek MJ, Lachman H, Leppert M, Li MD, Madden P, Miner C, Pollock JD, Pomerleau O, Rice JP, Rutter JL, Shurtleff D, Swan GE, Tischfield JA, Tsuang M, Uhl GR, Vanyukov M, Volkow ND, Wanke K. Setting Priorities for Genomic Research Science 2004, 304: 1445-1447. PMID: 15178784, DOI: 10.1126/science.304.5676.1445c.
• Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1)Hernandez-Avila CA, Covault J, Gelernter J, Kranzler HR. Association study of personality factors and the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1) Psychiatric Genetics 2004, 14: 89-92. PMID: 15167694, DOI: 10.1097/01.ypg.0000107931.32051.c7.
• Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotypevan Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype American Journal Of Psychiatry 2004, 161: 525-531. PMID: 14992979, DOI: 10.1176/appi.ajp.161.3.525.
• Genomic regions controlling corticosterone levels in ratsPotenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats Biological Psychiatry 2004, 55: 634-641. PMID: 15013833, DOI: 10.1016/j.biopsych.2003.11.005.
• Typologies of drug dependence: comparative validity of a multivariate and four univariate modelsBasu D, Ball SA, Feinn R, Gelernter J, Kranzler HR. Typologies of drug dependence: comparative validity of a multivariate and four univariate models Drug And Alcohol Dependence 2004, 73: 289-300. PMID: 15036551, DOI: 10.1016/j.drugalcdep.2003.11.004.
• Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locusLappalainen J, Kranzler HR, Petrakis I, Somberg LK, Page G, Krystal JH, Gelernter J. Confirmation and fine mapping of the chromosome 1 alcohol dependence risk locus Molecular Psychiatry 2004, 9: 312-319. PMID: 15094791, DOI: 10.1038/sj.mp.4001429.
• CALCYON gene variation, schizophrenia, and cocaine dependenceLuo X, Kranzler H, Lappalainen J, Rosenheck R, Charney D, Zuo L, Erdos J, van Kammen DP, Gelernter J. CALCYON gene variation, schizophrenia, and cocaine dependence American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 125B: 25-30. PMID: 14755439, DOI: 10.1002/ajmg.b.20092.
• Genome-Wide Linkage Scan for Loci Predisposing to Social Phobia: Evidence for a Chromosome 16 Risk LocusGelernter J, Page GP, Stein MB, Woods SW. Genome-Wide Linkage Scan for Loci Predisposing to Social Phobia: Evidence for a Chromosome 16 Risk Locus American Journal Of Psychiatry 2004, 161: 59-66. PMID: 14702251, DOI: 10.1176/appi.ajp.161.1.59.
• NOTCH4 gene haplotype is associated with schizophrenia in African AmericansLuo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans Biological Psychiatry 2004, 55: 112-117. PMID: 14732589, DOI: 10.1016/s0006-3223(03)00588-2.
• A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T → C in African‐ and European‐AmericansZabetian CP, Romero R, Robertson D, Sharma S, Padbury JF, Kuivaniemi H, Kim K, Kim C, Köhnke MD, Kranzler HR, Gelernter J, Cubells JF. A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T → C in African‐ and European‐Americans American Journal Of Medical Genetics Part A 2003, 123A: 190-192. PMID: 14598346, DOI: 10.1002/ajmg.a.20300.
• Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in AlcoholicsNellissery M, Feinn RS, Covault J, Gelernter J, Anton RF, Pettinati H, Moak D, Mueller T, Kranzler HR. Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics Alcoholism Clinical And Experimental Research 2003, 27: 1402-1408. PMID: 14506400, DOI: 10.1097/01.alc.0000085588.11073.bb.
• Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐AmericansLuo X, Kranzler HR, Zhao H, Gelernter J. Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European‐Americans American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 120B: 97-108. PMID: 12815747, DOI: 10.1002/ajmg.b.20034.
• The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase ActivityZabetian CP, Buxbaum SG, Elston RC, Köhnke MD, Anderson GM, Gelernter J, Cubells JF. The Structure of Linkage Disequilibrium at the DBH Locus Strongly Influences the Magnitude of Association between Diallelic Markers and Plasma Dopamine β-Hydroxylase Activity American Journal Of Human Genetics 2003, 72: 1389-1400. PMID: 12730829, PMCID: PMC1180300, DOI: 10.1086/375499.
• A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent PatientsOslin DW, Berrettini W, Kranzler HR, Pettinati H, Gelernter J, Volpicelli JR, O'Brien CP. A Functional Polymorphism of the μ-Opioid Receptor Gene is Associated with Naltrexone Response in Alcohol-Dependent Patients Neuropsychopharmacology 2003, 28: 1546-1552. PMID: 12813472, DOI: 10.1038/sj.npp.1300219.
• Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1)Hernandez‐Avila C, Wand G, Luo X, Gelernter J, Kranzler HR. Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the μ‐opioid receptor locus (OPRM1) American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 118B: 60-65. PMID: 12627468, DOI: 10.1002/ajmg.b.10054.
• Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptorDuan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor Human Molecular Genetics 2003, 12: 205-216. PMID: 12554675, DOI: 10.1093/hmg/ddg055.
• Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association studyYamamoto K, Cubells JF, Gelernter J, Benkelfat C, Lalonde P, Bloom D, Lal S, Labelle A, Turecki G, Rouleau GA, Joober R. Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 117B: 33-38. PMID: 12555232, DOI: 10.1002/ajmg.b.10011.
• Mutation screen of the glutamate decarboxylase‐67 gene and haplotype association to unipolar depressionLappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, Price LH, Krystal J, Gelernter J. Mutation screen of the glutamate decarboxylase‐67 gene and haplotype association to unipolar depression American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2003, 124B: 81-86. PMID: 14681921, DOI: 10.1002/ajmg.b.20055.
• A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppressionAhn J, Won TW, Kaplan DE, Londin ER, Kuzmič P, Gelernter J, Gruen JR. A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression Human Genetics 2002, 111: 339-349. PMID: 12384775, DOI: 10.1007/s00439-002-0771-x.
• Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary dataBoutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data Biological Psychiatry 2002, 51: 683-686. PMID: 11955469, DOI: 10.1016/s0006-3223(01)01237-9.
• Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletionMoreno FA, Rowe DC, Kaiser B, Chase D, Michaels T, Gelernter J, Delgado PL. Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion Molecular Psychiatry 2002, 7: 213-216. PMID: 11840315, DOI: 10.1038/sj.mp.4000962.
• Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in DepressionCubells J, Zabetian C, Anderson G, Price L, Meyers B, Malison R, Nelson J, Nagatsu T, Ichinose H, Gelernter J. Molecular Genetic Analysis of Plasma Dopamine β-Hydroxylase in Depression 2002, 53: 423-426. DOI: 10.1007/978-1-4757-3538-3_101.
• Association study of cannabinoid receptor gene (CNR1) alleles and drug dependenceCovault J, Gelernter J, Kranzler H. Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence Molecular Psychiatry 2001, 6: 501-502. PMID: 11526463, DOI: 10.1038/sj.mp.4000925.
• Linkage genome scan for loci predisposing to panic disorder or agoraphobiaGelernter J, Bonvicini K, Page G, Woods S, Goddard A, Kruger S, Pauls D, Goodson S. Linkage genome scan for loci predisposing to panic disorder or agoraphobia American Journal Of Medical Genetics 2001, 105: 548-557. PMID: 11496373, DOI: 10.1002/ajmg.1496.
• Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescentsZalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.
• Suicide, impulsive aggression, and HTR1B genotypeNew A, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever L. Suicide, impulsive aggression, and HTR1B genotype Biological Psychiatry 2001, 50: 62-65. PMID: 11457425, DOI: 10.1016/s0006-3223(01)01108-8.
• Polymorphism of the 5-HT1B Receptor Gene (HTR1B): Strong Within-Locus Linkage Disequilibrium without Association to Antisocial Substance DependenceKranzler HR, Hernandez-Avila CA, Gelernter J. Polymorphism of the 5-HT1B Receptor Gene (HTR1B): Strong Within-Locus Linkage Disequilibrium without Association to Antisocial Substance Dependence Neuropsychopharmacology 2001, 26: 115-122. PMID: 11751038, DOI: 10.1016/s0893-133x(01)00283-4.
• The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in HumansMartinez D, Gelernter J, Abi-Dargham A, van Dyck C, Kegeles L, Innis R, Laruelle M. The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans Neuropsychopharmacology 2001, 24: 553-560. PMID: 11282255, DOI: 10.1016/s0893-133x(00)00216-5.
• Family‐based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traitsZalsman G, Frisch A, Bromberg M, Gelernter J, Michaelovsky E, Campino A, Erlich Z, Tyano S, Apter A, Weizman A. Family‐based association study of serotonin transporter promoter in suicidal adolescents: No association with suicidality but possible role in violence traits American Journal Of Medical Genetics 2001, 105: 239-245. PMID: 11353442, DOI: 10.1002/ajmg.1261.
• Human GABAB receptor 1 gene: Eight novel sequence variantsHisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.
• An in-frame deletion in the α2C adrenergic receptor is common in African–AmericansFeng J, Zheng J, Gelernter J, Kranzler H, Cook E, Goldman D, Jones IR, Craddock N, Heston LL, Delisi L, Peltonen L, Bennett WP, Sommer SS. An in-frame deletion in the α2C adrenergic receptor is common in African–Americans Molecular Psychiatry 2001, 6: 168-172. PMID: 11317218, DOI: 10.1038/sj.mp.4000817.
• A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH LocusZabetian C, Anderson G, Buxbaum S, Elston R, Ichinose H, Nagatsu T, Kim K, Kim C, Malison R, Gelernter J, Cubells J. A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus American Journal Of Human Genetics 2001, 68: 515-522. PMID: 11170900, PMCID: PMC1235285, DOI: 10.1086/318198.
• Functional variants at CYP2A6: New genotyping methods, population genetics, and relevance to studies of tobacco dependenceZabetian C, Gelernter J, Cubells J. Functional variants at CYP2A6: New genotyping methods, population genetics, and relevance to studies of tobacco dependence American Journal Of Medical Genetics 2000, 96: 638-645. PMID: 11054771, DOI: 10.1002/1096-8628(20001009)96:5<638::aid-ajmg9>3.0.co;2-r.
• Family‐Based study of DRD2 alleles in alcohol and drug dependenceBlomqvist O, Gelernter J, Kranzler H. Family‐Based study of DRD2 alleles in alcohol and drug dependence American Journal Of Medical Genetics 2000, 96: 659-664. PMID: 11054774, DOI: 10.1002/1096-8628(20001009)96:5<659::aid-ajmg12>3.0.co;2-g.
• Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary ReportJacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report American Journal Of Psychiatry 2000, 157: 1700-1703. PMID: 11007732, DOI: 10.1176/appi.ajp.157.10.1700.
• Variant detection at the δ opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequenceGelernter J, Kranzler H. Variant detection at the δ opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence Human Genetics 2000, 107: 86-88. PMID: 10982041, DOI: 10.1007/s004390000340.
• Genetic polymorphism at the CLOCK gene locus and major depressionDesan P, Oren D, Malison R, Malison R, Price L, Price L, Rosenbaum J, Rosenbaum J, Smoller J, Smoller J, Charney D, Charney D, Gelernter J. Genetic polymorphism at the CLOCK gene locus and major depression American Journal Of Medical Genetics 2000, 96: 418-421. PMID: 10898925, DOI: 10.1002/1096-8628(20000612)96:3<418::aid-ajmg34>3.0.co;2-s.
• Apolipoprotein E ε4 allele is associated with atrophy of the amygdala in Alzheimer's diseasevan Dyck C, Basso M, Yang J, Half L, MacAvoy M, Varma P, Gelernter J. Apolipoprotein E ε4 allele is associated with atrophy of the amygdala in Alzheimer's disease Neurobiology Of Aging 2000, 21: 39. DOI: 10.1016/s0197-4580(00)82852-3.
• Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjectsGelernter J, Kranzler H, Cubells J. Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects Molecular Psychiatry 1999, 4: 476-483. PMID: 10523821, DOI: 10.1038/sj.mp.4000556.
• D2 Dopamine Receptor Gene (DRD2) Allele and Haplotype Frequencies in Alcohol Dependent and Control Subjects: No Association with Phenotype or Severity of PhenotypeGelernter J, Kranzler H. D2 Dopamine Receptor Gene (DRD2) Allele and Haplotype Frequencies in Alcohol Dependent and Control Subjects: No Association with Phenotype or Severity of Phenotype Neuropsychopharmacology 1999, 20: 640-649. PMID: 10327432, DOI: 10.1016/s0893-133x(98)00110-9.
• No association between D2 dopamine receptor (DRD2) “A” system alleles, or DRD2 haplotypes, and posttraumatic stress disorderGelernter J, Southwick S, Goodson S, Morgan A, Nagy L, Charney D. No association between D2 dopamine receptor (DRD2) “A” system alleles, or DRD2 haplotypes, and posttraumatic stress disorder Biological Psychiatry 1999, 45: 620-625. PMID: 10088049, DOI: 10.1016/s0006-3223(98)00087-0.
• No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-AmericansGelernter J, Kranzler H, Satel S. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans Biological Psychiatry 1999, 45: 340-345. PMID: 10023512, DOI: 10.1016/s0006-3223(97)00537-4.
• Population studies of polymorphisms of the serotonin transporter protein geneGelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. Population studies of polymorphisms of the serotonin transporter protein gene American Journal Of Medical Genetics 1999, 88: 61-66. PMID: 10050969, DOI: 10.1002/(sici)1096-8628(19990205)88:1<61::aid-ajmg11>3.0.co;2-k.
• Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American SubjectsGelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. Serotonin Transporter Protein Gene Polymorphism and Personality Measures in African American and European American Subjects American Journal Of Psychiatry 1998, 155: 1332-1338. PMID: 9766763, DOI: 10.1176/ajp.155.10.1332.
• Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))Gelernter J, Kranzler H, Lacobelle J. Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF)) Genomics 1998, 52: 289-297. PMID: 9790747, DOI: 10.1006/geno.1998.5454.
• DRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese SubjectsGelernter J, Kranzler H, Cubells JF, Ichinose H, Nagatsu T. DRD2 Allele Frequencies and Linkage Disequilibria, Including the -141CIns/DelPromoter Polymorphism, in European-American, African-American, and Japanese Subjects Genomics 1998, 51: 21-26. PMID: 9693029, DOI: 10.1006/geno.1998.5264.
• Dopamine β-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variationCubells J, van Kammen D, Kelley M, Anderson G, O’Connor D, Price LH, Malison R, Rao P, Kobayashi K, Nagatsu T, Gelernter J. Dopamine β-hydroxylase: two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation Human Genetics 1998, 102: 533-540. PMID: 9654201, DOI: 10.1007/s004390050736.
• D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor geneLaruelle M, Gelernter J, Innis RB. D2 receptors binding potential is not affected by Taq1 polymorphism at the D2 receptor gene Molecular Psychiatry 1998, 3: 261-265. PMID: 9672902, DOI: 10.1038/sj.mp.4000343.
• Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorderMcDougle CJ, Epperson CN, Price LH, Gelernter J. Evidence for linkage disequilibrium between serotonin transporter protein gene (SLC6A4) and obsessive compulsive disorder Molecular Psychiatry 1998, 3: 270-273. PMID: 9672904, DOI: 10.1038/sj.mp.4000391.
• Tryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary studyNew A, Gelernter J, Yovell Y, Trestman R, Nielsen D, Silverman J, Mitropoulou V, Siever L. Tryptophan hydroxylase genotype is associated with impulsive‐aggression measures: a preliminary study American Journal Of Medical Genetics 1998, 81: 13-17. PMID: 9514581, DOI: 10.1002/(sici)1096-8628(19980207)81:1<13::aid-ajmg3>3.0.co;2-o.
• D4 Dopamine-Receptor (DRD4) Alleles and Novelty Seeking in Substance-Dependent, Personality-Disorder, and Control SubjectsGelernter J, Kranzler H, Coccaro E, Siever L, New A, Mulgrew CL. D4 Dopamine-Receptor (DRD4) Alleles and Novelty Seeking in Substance-Dependent, Personality-Disorder, and Control Subjects American Journal Of Human Genetics 1997, 61: 1144-1152. PMID: 9345090, PMCID: PMC1716050, DOI: 10.1086/301595.
• Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjectsGelernter J, Kranzler H, Cubells J. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects Human Genetics 1997, 101: 243-246. PMID: 9402979, DOI: 10.1007/s004390050624.
• Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patientsMann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients American Journal Of Psychiatry 1997, 154: 1451-1453. PMID: 9326831, DOI: 10.1176/ajp.154.10.1451.
• Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's diseaseGelernter J, Van Dyck C, van Kammen D, Malison R, Price L, Cubells J, Berman R, Charney D, Heninger G. Ciliary neurotrophic factor null allele frequencies in schizophrenia, affective disorders, and Alzheimer's disease American Journal Of Medical Genetics 1997, 74: 497-500. PMID: 9342199, DOI: 10.1002/(sici)1096-8628(19970919)74:5<497::aid-ajmg8>3.0.co;2-l.
• Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH)Cubells J, Kobayashi K, Nagatsu T, Kidd K, Kidd J, Calafell F, Kranzler H, Ichinose H, Gelernter J. Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH) American Journal Of Medical Genetics 1997, 74: 374-379. PMID: 9259372, DOI: 10.1002/(sici)1096-8628(19970725)74:4<374::aid-ajmg7>3.0.co;2-p.
• Candidate Genes and Psychiatric Genetics: Tomorrow Never KnowsGelernter J, Crowe R. Candidate Genes and Psychiatric Genetics: Tomorrow Never Knows Psychiatric Annals 1997, 27: 262-267. DOI: 10.3928/0048-5713-19970401-08.
• The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette SyndromeGelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.
• Genetics of bipolar affective disorder: time for another reinvention?Gelernter J. Genetics of bipolar affective disorder: time for another reinvention? American Journal Of Human Genetics 1995, 56: 1262-6. PMID: 7762549, PMCID: PMC1801084.
• Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17Gelernter J, Pakstis AJ, Kidd KK. Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17 Human Genetics 1995, 95: 677-680. PMID: 7789954, DOI: 10.1007/bf00209486.
• Testing pathophysiologic hypotheses of psychiatric illness by molecular genetic approachesGejman P, Gelernter J, Cravchik A, Gershon E, Pickar D. Testing pathophysiologic hypotheses of psychiatric illness by molecular genetic approaches Schizophrenia Research 1995, 15: 39. DOI: 10.1016/0920-9964(95)95126-t.
• Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndromeGelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.
• Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced ParanoiaGelernter J, Kranzler H, Satel S, Rao P. Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia Neuropsychopharmacology 1994, 11: 195-200. PMID: 7865100, DOI: 10.1038/sj.npp.1380106.
• Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to ClozapineRao PA, Pickar D, Gejman PV, Ram A, Gershon ES, Gelernter J. Allelic Variation in the D4 Dopamine Receptor (DRD4) Gene Does Not Predict Response to Clozapine JAMA Psychiatry 1994, 51: 912-917. PMID: 7944879, DOI: 10.1001/archpsyc.1994.03950110072009.
• No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble EP, Kranzler HR, O'Malley S. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 1994, 271: 204-8. PMID: 8277546, DOI: 10.1001/jama.271.3.204.
• No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or Schizophrenia: Analysis Using Denaturing Gradient Gel ElectrophoresisGejman P, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble E, Kranzler H, O'Malley S, Hamer D, Whitsitt F, Rao P, DeLisi L, Virkkunen M, Linnoila M, Goldman D, Gershon E. No Structural Mutation in the Dopamine D2 Receptor Gene in Alcoholism or Schizophrenia: Analysis Using Denaturing Gradient Gel Electrophoresis JAMA 1994, 271: 204-208. DOI: 10.1001/jama.1994.03510270050038.
• PstI RFLP at the SERT locus.Gelernter J, Freimer M. PstI RFLP at the SERT locus. Human Molecular Genetics 1994, 3: 383. PMID: 7911700, DOI: 10.1093/hmg/3.2.383.
• Mutational analysis of candidate genes in psychiatric disordersGejman P, Gelernter J. Mutational analysis of candidate genes in psychiatric disorders American Journal Of Medical Genetics 1993, 48: 184-191. PMID: 8135301, DOI: 10.1002/ajmg.1320480404.
• Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16Gelernter J, Kruger S, Pakstis A, Pacholczyk T, Sparkes R, Kidd K, Amara S. Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16 Genomics 1993, 18: 690-692. PMID: 7905857, DOI: 10.1016/s0888-7543(05)80375-1.
• Alcoholism and the D2 Dopamine Receptor Gene-ReplyGelernter J, Risch N, Goldman D. Alcoholism and the D2 Dopamine Receptor Gene-Reply JAMA 1993, 270: 1547-1548. DOI: 10.1001/jama.1993.03510130053028.